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The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The retention of oral drug dosage forms in the stomach is improved by using swellable dosage forms that are shaped in a manner that will prevent them from inadvertently passing through the pylorus as a result of being in a particular orientation. The planar projection of the shape is one that has two orthogonal axes of different lengths, the longer being short enough to permit easy swallowing prior to swelling while the shorter is long enough within one-half hour of swelling to prevent passage through the pylorus.

The present invention provides an apparatus and method for moving playing cards from a first group of cards into plural hands of cards, wherein each of the hands contains a random arrangement of the same quantity of cards. The apparatus comprises a card receiver for receiving the first group of cards, a single stack of card-receiving compartments generally adjacent to the card receiver, the stack generally vertically movable, an elevator for moving the stack, a card-moving mechanism between the card receiver and the stack, and a microprocessor that controls the card-moving mechanism and the elevator so that an individual card is moved into an identified compartment. The number of compartments receiving cards and the number of cards moved to each compartment may be selected.

Various techniques are provided for carrying out peer-to-peer financial transactions using one or more electronic devices. In one embodiment, a request for payment is transmitted from a first device to a second device using a near field communication (NFC) interface. In response to the request, the second device may transmit payment information to the first device. The first device may select a crediting account and, using a suitable communication protocol, may communicate the received payment information and selected crediting account to one or more external financial servers configured to process and determine whether the payment may be authorized. If the payment is authorized, a payment may be credited to the selected crediting account. In a further embodiment, a device may include a camera configured to obtain an image of a payment instrument. The device may further include an application to extract payment information from the acquired image.

An implantable medical lead for stimulation of the sacral nerves comprises a lead body which includes a distal end and a proximal end, and the distal end having at least one electrode contact having a length of between 0.10 and 1.50 inches extending longitudinally from the distal end toward the proximal end. The lead body at its proximal end may be coupled to a pulse generator, additional intermediate wiring, or other stimulation device. The implantable medical lead can comprise a first and second electrode contacts. The second electrode contact has a length of between 0.030 and 1.00 extending longitudinally from a point approximately 1.00 from the distal end toward the proximal end. The first and second electrode contacts do no overlap longitudinally. The implantable lead is implanted by taking the lead and implanting near the sacral nerves and then connecting to a pulse generator.

A point of sale (POS) device may be configured to locate a payment system and transmit a payment authorization request from a remote location to a payment system, either directly, or via a payment system directory and/or a SSL Gateway. The invention also includes inserting third party account information into an encrypted portion of the payment request, so the payment request appears as a normal request to the issuing bank, but the third party account information may be used by the third party to bill the customer. The payment system directory is further configured to determine one or more payment processors to direct a payment authorization request, such that a single transaction may me allocated among multiple payment processors for authorization. Moreover, the payment system directory is able to format alternative payment methods into a format that is able to be processed over existing payment networks.

An access and cannulation device includes a mounting element such as the anastomosis mounting element disclosed in U.S. application Ser. No. 08/714,615 (now U.S. Pat. No. 5,868,763) and U.S. application Ser. No. 09/200,796. The device is used to provide access therethrough and via an incision to the interior of a hollow anatomical structure such as a vessel, an organ or the like during surgery, especially minimally invasive surgery. It includes a flexible sleeve with a suture therein for closing the sleeve and locating edges of the structure adjacent to the incision in position for proper healing after completion of a surgical procedure. A tool is also disclosed for manipulating the device to configure it for the surgery and to close it after completion of the surgery whereby the edges of the wall of the structure adjacent to an incision are approximated to promote proper healing.

A system and method that facilitate efficient use of 3G high-speed data networks while providing for personalized audio content selection and coordinated distribution of selected content are disclosed. The invention categorizes audio content to be delivered over wireless networks such that the categories correspond to a different delivery priority. In an illustrative three-category implementation, category 1 content has the highest delivery priority for delivery as soon as possible, category 2 content has the next highest delivery priority for delivery, and category 3 content, such as music, audio books and so on, has the least urgent delivery priority. The categories are used to coordinate audio content delivery to efficiently use available bandwidth and network resources by delivering content at off-peak times. The invention also allows the downloading process to be interruptible such that it can be resumed at about the point of an interruption to conserve resources.

A precursor composition for the deposition and formation of an electrical feature such as a conductive feature. The precursor composition advantageously has a viscosity of at least about 1000 centipoise and can be deposited by screen printing. The precursor composition also has a low conversion temperature, enabling the deposition and conversion to an electrical feature on low temperature substrates. A particularly preferred precursor composition includes silver and/or copper metal for the formation of highly conductive features.

A system and method for establishing centralized, out-of-band access to remote network elements is provided. Status and other information can be securely retrieved from the remote elements. One or more servers observe and manage a plurality of remote elements using modem-to-modem communications between a modem bank and a remote modem. Requests are submitted through a central mediation point, thereby allowing central control of user profiles and a collection of security audit log information. One or more authentication mechanisms provide enforced security measures and trusted communication paths between a user and a remote element. Remote elements can be securely monitored and administered from a central location.

The present invention provides an oral dosage form comprising a first composition and a second composition. The first composition comprises an effective amount of a therapeutic agent and the second composition comprises an effective amount of an adverse-effect agent. The adverse-effect agent is covered with a coating that is substantially insoluble in the gastrointestinal tract. In one embodiment, the adverse-effect agent is coated with an outer base-soluble layer and an inner acid-soluble layer. The therapeutic agent can be uncoated or can be coated with a coating having an outer acid-soluble layer and an inner base-soluble layer. The dosage form discourages administration of the therapeutic agent by other than oral administration.

A semiconductor device, comprising a first semiconductor portion having a first end, a second end, and a slit portion, wherein the width of the slit portion is less than the width of at least one of the first end and the second end; a second portion that is a different material than the first semiconductor portion, a third portions that is a different material than the first semiconductor portion, wherein the second and third portions are on opposite sides of the slit portion, and at least three terminals selected from a group consisting of a first terminal connected to the first end, a second terminal connected to the second end, a third terminal connected to the second portion, and a fourth terminal connected to the third portion.

General purpose methods for the fabrication of integrated circuits from flexible membranes formed of very thin low stress dielectric materials, such as silicon dioxide or silicon nitride, and semiconductor layers. Semiconductor devices are formed in a semiconductor layer of the membrane. The semiconductor membrane layer is initially formed from a substrate of standard thickness, and all but a thin surface layer of the substrate is then etched or polished away. In another version, the flexible membrane is used as support and electrical interconnect for conventional integrated circuit die bonded thereto, with the interconnect formed in multiple layers in the membrane. Multiple die can be connected to one such membrane, which is then packaged as a multi-chip module. Other applications are based on (circuit) membrane processing for bipolar and MOSFET transistor fabrication, low impedance conductor interconnecting fabrication, flat panel displays, maskless (direct write) lithography, and 3D IC fabrication.

The present invention is directed to systems and methods which monitor a network environment, collect client information available online, and refine location determinations of individual clients based on observed information as well as online information. More particularly, the present invention is directed to systems and methods which monitor the wireless network, collect online receive signal strength indicator (RSSI) information observations from client users, without requiring knowledge of those clients' locations. The present invention is additionally directed to systems and methods to enhance the accuracy of the location determinations in a network, based on observed client information such as, for example, signal strength references.

There is provided a flexible display having a plurality of innovations configured to allow bending of a portion or portions to reduce apparent border size and/or utilize the side surface of an assembled flexible display.

A prosthetic aortic valve is designed to be implanted in the natural aortic annulus and to extend into the ascending aorta to a point short of the right and left coronary arteries. Blood leakage around the valve is prevented by tension in one or more circumferential cords drawing annular tissue into sealing contact with an external sealing ring on the valve body. The security of the valve's attachment to a patient is assured with a plurality of interrupted sutures between a semirigid flange on the valve outer surface and the patient's aortic commissures and/or the patient's ascending aortic wall. The sutures are preferably attached to posts or cleats on the semirigid sewing flange, the flange being spaced apart from the valve inlet by the sealing ring.

A gateway is provided which includes an interface to a command memory of a content routing server, interfaces to different types of content nodes, protocol translators to transform communications between the command memory of the content routing server and the interfaces to the content nodes. The gateway may interface to content nodes that are servers or to content nodes that are client. The gateway provides a common interface to the command memory of the content routing server for coupling content and metadata to content nodes operating disparate protocols.

Electrical shield line systems are provided for openings in common electrodes near data lines of display and touch screens. Some displays, including touch screens, can include multiple common electrodes (Vcom) that can have openings between individual Vcoms. Some display screens can have an open slit between two adjacent edges of Vcom. Openings in Vcom can allow an electric field to extend from a data line through the Vcom layer. A shield can be disposed over the Vcom opening to help reduce or eliminate an electric field from affecting a pixel material, such as liquid crystal. The shield can be connected to a potential such that electric field is generated substantially between the shield and the data line to reduce or eliminate electric fields reaching the liquid crystal.

The remaining run-time (t_rem) of a battery is determined independently of the condition of the battery and the amount of load on the battery by obtaining the value of a present total zero-current capacity (Qmax) of the battery based on relaxed-battery OCV values measured just before and just after a charging or discharging cycle. A current through the battery is integrated to determine a transfer of charge (Q) from the battery, and a value of total run-time (t_total) that would be required to reduce the open circuit voltage of the battery to a predetermined lower limit (Vmin) is determined. The remaining run-time (t_rem) is determined by subtracting the duration of the integrating from the total run-time (t_total).