An applicator (26) as part of a
system for accepting chyme from the
stomach and for bypass-type conducting the chyme through the
pylorus in or through the
duodenum of a patient, the
system comprising: a transpyloric and, if applicable, transduodenal bypass device (1), comprising: a tubular, preferably radially collapsible and self-erecting transpyloric conducting element (4,7), which is or has to be placed in a patient in such a way that it penetrates the
pylorus of the patient and is provided with a central conducting lumen for the chyme, fixing elements for anchoring the transpyloric conducting element (4,7) on the
pylorus in the form of a gastric anchor element, and / or in the form of a duodenal anchor element, an upstream mouth to be placed antegrade of the pylorus, and a downstream mouth to be placed retrograde of the pylorus, in order to (i) accept the chyme from the
stomach, to (ii) bypass-type conduct the chyme through the pylorus and, if applicable, through the
duodenum or a part of the
duodenum, and to (iii) release the chyme in or beyond the duodenum of the patient; an
endoscope or a
catheter or a similar positioning device, comprising: an elongated shaft (28), and a proximal end extending extracorporeally; the applicator (26) for releasably
coupling the transpyloric and, if applicable, transduodenal bypass device (1) to the external surface of the shaft (28) of the
endoscope or
catheter or similar positioning device, in order to insert the bypass device (1) under direct guidance of the
endoscope or
catheter or similar positioning device from the outside of the patient's body in an antegrade way through the
upper digestive tract into the
stomach, or in order to remove it in a retrograde way through the
upper digestive tract, characterized in that the applicator (26) comprises a
coupling element (27), which is or can be slid onto or along the external surface of the shaft (28), and which entirely or partially penetrates the central conducting lumen of the transpyloric conducting element (4,7) of the bypass device (1), thereby at least partially bridging a gap between the external surface of the shaft (28) and an internal surface of the central conducting lumen of the bypass device (1), wherein the
coupling element (27) of the applicator (26) acts as a releasable fixation mechanism between the bypass device (1) and the shaft (28).