1results about How to "Accelerate the accumulation process" patented technology

The application provides a preparation method of an aggregation-induced emission nanoparticle, which comprises the following steps: adopting triphenylamine as an electron donor (D), pyridine bromide as an electron acceptor (A), constructing a D-π-A structure, and synthesizing a nanoscale AIE photosensitizer nanoparticle by acting with an albumin stock solution; the nanoparticle synthesis method is easy to operate, has high yield and low cost, can simultaneously generate type I and type II reactive oxygen species (ROS), including ·OH (type I) and O2 (type II), and has good mitochondrial targeting function, and a Pearson correlation coefficient is as high as 0.97. 1 In addition, due to the modification of the terminal carboxyl group of TTPA, the nanoparticle has a pH response effect, can increase the accumulation or endocytosis of the nanoparticle in tumors, and can enhance the in-vivo imaging and treatment effect, and has potential clinical application value of intelligent response cancer diagnosis and treatment function.