346results about How to "Accelerate the accumulation process" patented technology

The present invention is directed to conjugates such as polymeric prodrugs of aromatic, hydroxyl-containing compounds and methods of making and using the same. These polymeric prodrugs are preferably esters of hydroxyl-containing aromatic compounds and are formed by reacting a desired aromatic, hydroxyl-containing compound with a substantially non-antigenic polymer so as to produce a transport form having an ester linkage between the aromatic compound and the polymer. Preferred aromatic hydroxyl-containing compositions include 10- and 11-hydroxycamptothecin derivatives. Methods of treatment are also disclosed.

Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and / or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.

The invention relates to a bio-organic compound fertilizer, which comprises the following components in part by weight: 10 to 30 parts of organic matter, 2 to 10 parts of compound microbial inoculants, 5 to 20 parts of humic acid, 5 to 20 parts of amino acid, 4 to 10 parts of chitin, 1 to 5 parts of polypeptide, 530 parts of nitrogen, phosphorus and potassium, 5 to 10 parts of secondary and trace elements, 5 to 15 parts of algae fertilizer, 5 to 10 parts of zeolite powder and 1 to 5 parts of synergistic agent. Through the scientific and rational formula, the bio-organic compound fertilizer achieves nutritive equilibrium and can satisfy the need of crop growth in nutrient. The microbial inoculants are added to quickly degrade natural macromolecular organic compounds into the organic fertilizer and decompose organic pollutants, which effectively improves the capacity of crops in the absorption of nutrient components, reduces the waste of the fertilizer and reduces the damage of the chemical fertilizer to soil to further achieve the nutritive equilibrium, satisfy the need of the crop growth in the nutrient, achieve the aims of low investment and high output value, improve the quality of the crops and improve the economic benefit brought by the crops.

A gas / liquid separator comprising a vertical vessel having an inlet for a gas / liquid mixture; a gas / liquid separation device arranged within the vessel, which separation device has an inlet in fluid communication with the inlet of the vessel, and an outlet means for at least partially separated gas and liquid; an outlet for gas from the vessel, above and in fluid communication with the outlet means of the separation device; a liquid collection space in the vessel, below and in fluid communication with the outlet means of the separation device; and an outlet for liquid from the vessel, having a receiving end in the liquid collection space, wherein the gas / liquid separation device is a vane inlet device and wherein between the separation device and the liquid collection space a liquid collection promoter tray is arranged, forming a receiving area for liquid impinging on the tray from above and having a passage for liquid received on the receiving area to flow to the liquid collection space; and the use of such a gas / liquid separator.

The present invention provides methods of treating overweight or obese patients with an inflatable weight control device that is implanted in the patient's digestive tract. A first method comprises the steps of providing the weight control device which includes an inflatable body having a first bulb, a second bulb, an intermediate portion, and an internal passageway extending from the first bulb through the intermediate portion and to the second bulb. The inflatable body includes a valve assembly that is grasped by the endoscope during insertion of the weight control device in the patient's pylorus. Next, the endoscope is used to position the weight control device within the pylorus such that the intermediate portion resides within the pyloric valve and the first bulb resides within the pyloric antrum. The weight control device is then inflated with the endoscope such that the first bulb engages an inner surface of the pyloric antrum to form an outlet obstruction within the pyloric antrum. This obstruction causes chyme to accumulate proximate the first bulb prior to entering the internal passageway where it is then transported through the body and discharged from the second bulb into the patient's duodenum. The accumulation of chyme in pyloric antrum and the stomach causes the patient to feel full and stop eating. Thus, the treatment method provides a gastric outlet obstruction that slows the passage of chyme into the duodenum and as a result, the patient feels full and stops eating after consuming relatively small portions.

The invention has supplied biological leaf fertilizer, whose characteristics is that it includes chemical agent, biological organic matter, chelating agent, penetrant and microbe fermentation liquor and the solid raw material and mess ratio are: urea50-55%, potassium dihydrogenphosphate20-25%, potassium chloride 7-8%, boric acid0.3-0.5%, boric acid0.2-0.4%, copper sulfate0.1-0.2%, calcium nitrate0.5-1.5%, magnesium sulfate0.2-0.4%, zinc sulfate0.2-0.4%, manganese sulphate0.2-0.3%, ammonium molybdate0.05-0.1%, fulvic acid14-15%, EDTA chelating agent1-2%, AEO-20 penetrant 0.05-0.1%, mix the raw material of the above mix water 160~70deg.C in the ratio of 2:3, after 24 hours, add microbe fermentation liquor into the liquid filtered by 0.5~1mL / kg, then adjust the PH value to 5.0~6.0, finally, obtain the invention. The leaf fertilizer contains lots of macroelements and all kinds of secondary and microelements, and also contains metabolic product of microbe fermentation, beneficial microbe flora,chelating agent, penetrant and growth regulating agent, without poison, smell and side effect, it is safe and reliable, can increase the quantity and quality of agricultural products.

The present invention provides an endoscopically implantable weight control device that forms a gastric outlet obstruction in a patient's digestive tract. The weight control device includes an inflatable body residing within the patient's pylorus and between the stomach and duodenum. The body features a first bulbous portion and a second bulbous portion, the exterior dimensions of the first bulbous portion exceeding the exterior dimension of the second bulbous portion. The body also includes an intermediate portion with exterior dimensions that are less than the exterior dimensions of both the first and second bulbous portions, wherein the intermediate portion resides within the patient's pyloric valve when the device is implanted. An internal passageway extends through the body, wherein the passageway receives and allows for the passage of chyme from the stomach to the duodenum. A method of treating obese patients with the inflatable weight control device utilizing a sequence of different-sized devices is also provided.

A gas / liquid separator comprising a vertical vessel having an inlet for a gas / liquid mixture; a gas / liquid separation device arranged within the vessel, which separation device has an inlet in fluid communication with the inlet of the vessel, and an outlet means for at least partially separated gas and liquid; an outlet for gas from the vessel, above and in fluid communication with the outlet means of the separation device; a liquid collection space in the vessel, below and in fluid communication with the outlet means of the separation device; and an outlet for liquid from the vessel, having a receiving end in the liquid collection space, wherein the gas / liquid separation device is a vane inlet device and wherein between the separation device and the liquid collection space a liquid collection promoter tray is arranged, forming a receiving area for liquid impinging on the tray from above and having a passage for liquid received on the receiving area to flow to the liquid collection space; and the use of such a gas / liquid separator.

A system and method are provided for preventing damage to the epidermis or other epithelial or non-target tissue during photodynamic therapy treatment. For example, an inhibiting radiation can be used to control formation of a photosensitizer from a precursor photosensitizer in the epidermis or epithelial tissue. Subsequent application of a treatment radiation can activate the photosensitizer to damage or destroy target sites while the non-target tissue remains substantially unaffected.

Disclosed are products useful as, or in, drug delivry vehicles.

Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides which have particular in vivo properties, targeted to nucleic acids encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for treatment of diseases are provided.

The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including both bacteria and plants. The new pathways provide means for producing 4HB containing PHAs from cheap carbon sources such as sugars and fatty acids, in high yields, which are stable. Useful strains are obtaining by screening strains having integrated into their genomes a gene encoding a 4HB-CoA transferase and / or PHA synthase, for polymer production. Processes for polymer production use recombinant systems that can utilize cheap substrates. Systems are provided which can utilize amino acid degradation pathways, α-ketoglutarate, or succinate as substrate.

A tellurite-based glass composition for use in EDFAs exhibits higher phonon energy without sacrificing optical, thermal or chemical durability properties. The introduction of boron oxide (B2O3) into the Er3+-doped tellurite glasses increases the phonon energy from typically 785 cm−1 up to 1335 cm−1. The inclusion of additional glass components such as Al2O3 has been shown to enhance the thermal stability and particularly the chemical durability of the boro-tellurite glasses. Er:Yb codoping of the glass does further enhance its gain characteristics.

The present invention relates to methods, systems and compositions, including genetically modified microorganisms, adapted to exhibit increased tolerance to 3-hydroxypropionic acid (3-HP), particularly through alterations to interrelated metabolic pathways identified herein as the 3-HP toleragenic pathway complex (“3HPTGC”). In various embodiments these organisms are genetically modified so that an increased 3-HP tolerance is achieved. Also, genetic modifications may be made to provide at least one genetic modification to any of one or more 3-HP biosynthesis pathways in microorganisms comprising one or more genetic modifications of the 3HPTGC.

A circuit arrangement for operating a solenoid actuator, for example, an electric motor provided in the form of a switched reluctance motor, permits operation of the motor in the event of malfunction or failure of part of an energy supply. The circuit arrangement advantageously includes an auxiliary battery serving as a redundance in addition to a main battery. The auxiliary battery is smaller and has a lower nominal voltage than the main battery. In order to permit continued operation of the electric motor in the event of failure, with a nominal operating voltage which is adapted to the nominal voltage of the main battery, a capacitor which can be switched on and off is connected in series to the batteries. An energy quantity can be accumulated in the capacitor by switching the current switching through an exciter winding of the electric motor in the manner of a switching regulator, whereby the nominal voltage of the capacitor finally exceeds the voltage in the auxiliary battery. When a sufficient quantity of energy has been accumulated, the electric motor can be actuated for a short time by means of the energy accumulated in the capacitor. Electrically actuated braking systems in commercial vehicles represent a significant and preferred area of application for the invention.

The invention provides an amino acid foliar fertilizer, comprising the following materials in percentage by mass: 30 to 50 percent of plant amino acid, 1 to 5 percent of compound sodium nitrophenolate, 15 to 25 percent of urea, 5 to 10 percent of ferrous sulphate, 5 to 10 percent of borax, 3 to 5 percent of cupric sulfate, 0.1 to 1 percent of ammonium molybdate, 1 to 2 percent of manganese sulfate, 4 to 8 percent of zinc sulfate, 10 to 20 percent of organic silicon, and the balance water. The amino acid foliar fertilizer has obvious effects of exciting activity of enzyme in crops, improving the photosynthetic efficiency of the crops, accelerating nutrition absorption and operation inside the crops, increasing the content of chlorophyll, improving stem substance accumulation and sugar content, improving crop quality, and enhancing crop drought resistance, disease resistance and immunity and the like, can be absorbed by leaves, stems and roots of various commercial crops, such as Chinese cabbages and other vegetables, so as to lead the crops to be higher, and has remarkable effect in enhancing the performances of root growth, sprouting, seedling strengthening, flower promoting, fruit swelling, fruit protecting and other aspects for the crops.

The present invention provides a method for increasing the efficacy of antifolates which act via inhibition of dihydrofolate reductase (DHFR). The method comprises the steps of administration of 5-amino-4-imidazolecarboxamide riboside (Z) or its base with the antifolate such that the targeted cells are exposed to both the antifolate and Z simultaneously. This results in increased influx of the antifolate. For MTX, accumulation of the more biologically active polyglutamate forms is also potentiated. This potentiation appears to be mediated by an effect on the RFC.

According to the invention, there is provided a phosphate derivative of a compound having a secondary hydroxy group. The compound having a secondary hydroxyl group may, for example, be chosen from pravastatin, atorvastatin venlafaxine, their derivatives and mixtures thereof.

The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.

Protein antigens are provided. The protein antigens typically include a peptide antigen conjugated or fused to a chaperone protein to form a “chaperone-antigen” that increases lymph node uptake; improves an immune response; or a combination thereof relative to the peptide antigen alone. The immune response can be, for example, increased antigen-specific proliferation, enhanced cytokine production, stimulation of differentiation and / or effector functions, promotion of survival, rescue from exhaustion and / or anergy of T cells, or a combination thereof. Chaperon-antigens can also be used to induce tolerance and increase immune suppressive responses. In the most preferred embodiments, the peptide antigen is fused to the chaperone protein to form a fusion protein. The “chaperone-antigen” can be combined with an adjuvant to form a vaccine and administered to a subject to modulate an immune response to the antigen. Methods of increasing immune responses, treating cancer and infectious and inducing tolerance are also provided.

Disclosed are compositions that comprise one or more N-acylethanolamine compounds for maintaining the freshness and appearance of cut flowers, floral products, decorative foliage, fruits, and other plant cuttings. More specifically, the present invention provides methods for treating and storing cut flowers, Christmas trees, fruits, and other severed plant parts that preserve the appearance, freshness, fragrance and / or aesthetic qualities of the botanical products. Using the disclosed compositions, the shelf life of cut flowers was substantially prolonged, in many cases 2 to 5 times longer than untreated flowers, with the treated flowers or foliage appearing healthy and viable, and without wilting, dehydration, leaf drop, or visible signs of senescence. Likewise, treatment of ornamental coniferous plants with the anti-senescent compositions delayed deterioration and leaf drop, while extending the overall appearance and quality of the plants and plant cuttings.

The invention described herein pertains to a novel macrolide antibacterial agent of formula (I): A-L-Q, as defined herein, and pharmaceutically acceptable salts, solvates, and hydrates thereof. Inter alia, the new macrolide antibacterial agent is active against a number of bacterial species, including resistant species.

Disclosed is a dye-sensitized solar cell with enhanced photoelectric conversion efficiency. The dye-sensitized solar cell includes a first electrode of a light transmission material, a second electrode facing the first electrode, and a dye-absorbed porous layer formed on the first electrode. An electrolyte is injected between the first and the second electrodes. The porous layer contains first and second materials differing from each other in conduction band energy level.

The invention provides methods for the treatment of cancer in a subject using piperlongumine and / or piperlongumine analogs.

A method for generating Sendai virus particles by transfecting the Sendai virus genome to a host expressing all genes for the initial viral replication has been developed, enabling the genetic manipulation of Sendai virus and effective utilization of said virus as the vector.

A system and a method for effectively determining the measurement sensitivity, repeatability, and probe commonality to assist a test engineer determine if the tester meets the specified resolution at every test. A statistical measurement of inherent tester specifications are provided with the added accumulation of the probe contact resistance during the probing process. It further provides a feedback to the test probe card noise level while testing is in progress. Moreover, the system and the method determine the test probing integrity in-situ when testing integrated circuit chips or wafers, dynamically detecting probing errors, and modifying data associated with defective test probes.

The present invention relates to multi-ribozymes and their use to target RNA in a tissue-specific, target RNA-specific, or pathogen-specific manner for the treatment of cancers, proliferative disease, and bacterial, parasitic and viral infections. More specifically, the present invention relates to the use of virions and viral vectors to package and deliver DNA encoding the multi-ribozymes to a host. The present invention relates to the use of liposomes and lipid-DNA complexes to deliver DNA encoding ribozymes to a host. Most specifically, the invention relates to the use of target specific virions to package and deliver DNA comprising a target specific promoter and encoding a ribozyme(s) directed to the target organism nucleic acids. The present invention further relates to a novel vectors encoding a multi-ribozyme structure with enhanced 5' and / or 3' autocatalytically cleaving ribozymes. The invention further relates to nucleotides encoding a multi-ribozyme comprising one or more ribozyme cassettes which contain one or more trans-acting ribozymes and one or more autocatalytically cleaving ribozyme sequences.

The invention discloses a flue-cured tobacco mulch pyramidic hole transplanting method and a structure after flue-cured tobacco mulch pyramidic hole field-planting. The flue-cured tobacco mulch pyramidic hole transplanting method comprises the following steps of: a, digging a pyramidic tobacco seedling planting hole on a ridge for planting tobacco, wherein the size and shape of a pyramidic tip part of the pyramidic tobacco seedling planting hole are same as those of a matrix hole of a floating seedling-raising disc; b, placing the tobacco seedling cultured by the floating seedling-raising disc into the pyramidic tobacco seedling planting hole; and c, covering a mulch. According to the invention, the ridge is provided with the pyramidic planting hole, so that the lower end of the planting hole with the shape can be matched with the shape of a planting cup of the floating seedling-raising disc, thus the tobacco seedling can be directly placed in the planting hole during planting, so that procedures, such as seedling supporting and ridging are omitted during conventional planting, and human hands are prevented from being burnt by tobacco seedlings; and by adopting deephole planting which not only has a good effect and is superior to big hole digging for planting and small arch building for planting, but also can avoid the procedures of digging a big hole and building and dismantling a small arch, namely, the deephole planting can be finished by the conventional mulch and the conventional pavement method.

The present invention provides a composition comprising a polymer of a β-hydroxy short-medium chain fatty acid, which is used for delivering the β-hydroxy short-medium chain fatty acid or an oligomer thereof to the large intestine. In case the composition is administrated orally, the composition will be delivered to the large intestine, without being degraded in the stomach or short intestine, and degraded by the large intestinal bacterial flora and release the short-medium chain fatty acid or an oligomer thereof. The released short-medium chain fatty acid or an oligomer thereof has useful physiological activities and is effective for treating or preventing inflammatory diseases or cancer in the large intestine.