Beta hydroxy short to medium chain fatty acid polymer

a polymer technology, applied in the field of hydroxy short-to-medium chain fatty acid monomer, can solve the problems of increasing the production cost of short-to-medium-chain fatty acid, the influence of resistance carbohydrates, and the inability to convert administerable resistant carbohydrates into short-to-medium-chain fatty acids, etc., and achieves the reduction of volatile, hydrogen sulfide and total mercaptan,

Inactive Publication Date: 2006-12-07
EARTHUS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0196] Throughout the feeding period, only two out of 12 animals in the control group excreted normal feces whereas 8 out of 12 animals in the test group excreted normal feces, i.e. the significant effect of inhibiting soft feces and diarrhea was confirmed (p<0.05).
[0197] The odor of the control group was more irritate than that of the test group. Each odorous component are shown in Table 4 below. The declining trend and significant decline of the odor from the excretory substance were confirmed. That is, in the test group, the volatile fatty acid was decreased by about 25% and both hydrogen sulfide and total mercaptan were decreased by more than 40% from those of the control group (Table 4). TABLE 4Volatile Odorous Components from the Pig ExcretorySubstance (4 weeks)test groupcontrol groupodorous component (ppm)(SD)(SD)Volatile ammonia0.8(0.8) 0.6(0.3)Volatile fatty acid1-4 wk.6.9(3.2)*9.6(4.

Problems solved by technology

However, all of thus administrated resistant carbohydrates are not necessarily converted to short chain fatty acids.
The short chain fatty acid production efficiency from the resistant carbohydrates are generally low.
In addition, the fermentation speed of the resistant carbohydrates is greatly affected by the manner of intake or the existence form of the same in the food.
The other organic acids may affect badly.
For example, production or accumulation of a large amount of lactic acid may cause diarrhea.
However, such procedure allows only intermittent administration.
It is difficult to deliver the acid to entire large intestin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of poly(β-hydroxy Short-Medium Chain Fatty Acid)

reference example 1

[0154] i Ralstonia eutropha preculture was inoculated in 30 L culture medium shown below and incubated under aeration and agitation at 30° C. During the incubation, the pH was adjusted to 6.8 with aqueous ammonia and the consumed glucose was added accordingly. When the predetermined cell concentration was obtained, aqueous sodium hydrate was added instead of aqueous ammonium to start deposition of the polymer. The culture was incubated for total 3 days with keeping the addition of glucose to provide cells containing poly(β-hydroxybutyric acid). The cells were collected with centrifugation and treated with protease and then with aqueous hydrogen peroxide to isolate the polymer. The polymer was collected, washed with water and dried.

[0155] Culture Medium Formulation

glucose20g / Lammonium sulfate8g / Lmagnesium sulfate, heptahydrate0.5g / Lpotassium sulfate1.5g / L1N aqueous phosphate20mlminor mineral solution50ml

[0156] formulation of the minor mineral solution:

calcium chloride, dihydrate...

reference example 2

[0158] The same medium used in reference example 1 2000 L was used and the same microorganism was cultured in the same manner as reference example 1 except for using a mixture of glucose and propionic acid (9:1) in stead of glucose as carbon source for the deposition of the polymer added after the culture reached to the predetermined cell concentration. Thus obtained copolymer was analyzed by NMR and confirmed to comprise 5.4 mol % of β-hydroxyvaleric acid monomer unit. The weight average molecular weight determined with GPC was 737,000 and the yield was 49.8 g / L medium.

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Abstract

The present invention provides a composition comprising a polymer of a β-hydroxy short-medium chain fatty acid, which is used for delivering the β-hydroxy short-medium chain fatty acid or an oligomer thereof to the large intestine. In case the composition is administrated orally, the composition will be delivered to the large intestine, without being degraded in the stomach or short intestine, and degraded by the large intestinal bacterial flora and release the short-medium chain fatty acid or an oligomer thereof. The released short-medium chain fatty acid or an oligomer thereof has useful physiological activities and is effective for treating or preventing inflammatory diseases or cancer in the large intestine.

Description

TECHNICAL FIELD [0001] The present invention relates to a method for delivering a β-hydroxy short-medium chain fatty acid monomer or an oligomer thereof to the large intestine by means of oral administration or a procedure parallel to oral administration. The present invention further relates to a composition which is used for delivering a β-hydroxy short-medium chain fatty acid monomer or an oligomer thereof to the large intestine of a subject by means of oral administration or a procedure parallel to oral administration. [0002] Further, the invention relates to a novel animal feeding stuff. [0003] Further more, the invention relates to a pharmaceutical composition and a functional food product useful for keeping or improving physiologic function, for treating or preventing inflammatory bowel disease and for treating or preventing large intestine cancer. [0004] Still further, the invention relates to a coating composition useful for delivering an active ingredient to the large inte...

Claims

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Application Information

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IPC IPC(8): A61K31/765A23L33/12A23L33/135A61K31/78A61P1/00A61P1/06A61P1/10A61P1/12A61P1/14A61P3/06A61P13/00A61P13/02A61P25/00A61P35/00
CPCA23K1/164A23L1/3008A23V2002/00A61K31/78A23V2200/32A23K20/158A23L33/12A61P1/00A61P1/06A61P1/10A61P1/12A61P1/14A61P3/06A61P13/00A61P13/02A61P25/00A61P35/00A61K8/85A61K9/204A61K9/5153A61K47/34
Inventor USHIDA, KAZUNARIKURIYAMA, MASAKI
Owner EARTHUS
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