962results about "Synthetic polymeric active ingredients" patented technology

The invention discloses a porphyrin copper ion covalent organic framework material with excellent biocompatibility, and belongs to the technical field of biological medicines. The porphyrin copper ion covalent organic framework material is obtained by carrying out solvothermal reaction copolymerization on a porphyrin compound and a novel copper Schiff base boric acid complex in a protective atmosphere; the porphyrin compound is 5, 10, 15, 20-tetra (3, 4-dihydroxyphenyl) porphyrin, and the structural formula of the porphyrin compound is shown in the specification. The structural formula of the novel copper Schiff base boric acid complex is # imgabs0 #. According to the invention, a novel copper Schiff base complex and 5, 10, 15, 20-tetra (3, 4-dihydroxyphenyl) porphyrin are copolymerized to obtain Cu-COF with negligible biotoxicity, and the material realizes the synergistic effect of three antibacterial modes of PDT, PTT and hydroxyl free radicals. The prepared Cu-COF can also be slowly degraded in an acid environment, the infected microenvironment is improved in the degradation process, and the antibacterial effect is improved.

Compounds useful as biologically active compounds with or without fluorescent or colored dyes are disclosed. In some embodiments, the compounds have the following structure (I): (I) or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, L11, M1, M2, M3, l, m, n, p, and q are as defined herein. Additional compound, methods of preparation, pharmaceutical compositions, and methods of treatment related to compounds of Structure (I) are also provided.

The invention discloses an anti-tumor nano material based on copper death promotion as well as a preparation method and application of the anti-tumor nano material. The anti-tumor nano material is constructed by taking PCN-Cu as a metal organic framework compound and merging Pt nano particles with stable polyvinylpyrrolidone into the PCN-Cu, and the anti-tumor nano material is named as Pt-coated PCN-Cu. Experiments prove that the Pt-coated PCN-Cu can improve the concentration of copper ions in tumor cells, promote the lipoic acylation aggregation process of mitochondrial related proteins, promote degradation and proteotoxicity reaction of Fe-S cluster proteins and induce copper death of the tumor cells. The Pt-coated PCN-Cu has the advantages of being simple in preparation process, green, economical, low in cost, capable of being produced on a large scale and the like, has a good anti-tumor effect, expands a novel treatment mode for promoting tumor cell copper death, and provides a new technical means for tumor treatment.

The invention relates to the technical field of biological medicine, in particular to a ferroptosis inhibition type phospholipid-like material and application thereof. The ferroptosis inhibition type phospholipid-like material is one of the following structural general formulas (1)-(5). The biomimetic phospholipid-like ferroptosis inhibitor has a long retention characteristic in main positions (cell membranes, endoplasmic reticulum and other organelle membranes) of cell ferroptosis, so that the ferroptosis inhibition efficiency is remarkably improved. The novel phospholipid-like material not only can be used as an active drug molecule, but also can be used as a pharmaceutic adjuvant for constructing drug delivery carriers such as lipidosome and micelle and implant coatings, and is suitable for various administration routes such as oral administration, injection and local administration. The novel biomimetic ferroptosis inhibitor can efficiently relieve cell ferroptosis and has a wide application prospect in the field of treating or retarding ferroptosis-related diseases.

A polysilane methacrylic polymer and processes of preparing the polysilane methacrylic polymer are provided.

A dry eye composition containing hypochlorous acid and a demulcent. The demulcent can be polyvinylpyrrolidoe with a molecular weight of 30-50 kDa. The composition can be applied to the surface of the eye with a dropper device or a spray dispenser. Critically, hypochlorous acid is stable in the dry eye composition and maintains its effectiveness at preventing microbial growth.

The invention relates to the technical field of medicines, and provides mitoxantrone-loaded ZIF-8 nanoparticles, a preparation method thereof and an application of the mitoxantrone-loaded ZIF-8 nanoparticles in tumor chemical-immunotherapy. Aiming at the defects of combined chemotherapy and immunotherapy clinically at the present stage, MIT ZIF-8 synthesized by a normal-temperature full-water-phase one-pot method is used as a novel chemical-immunotherapy scheme, and the capability of inducing cell immunogenic death of a chemotherapeutic drug mitoxantrone is enhanced by utilizing pyroptosis; the anti-tumor immune activation capability is enhanced while tumor cells are killed through chemotherapy, effective chemical-immune therapy is achieved, and the responsiveness of tumors to immune checkpoint inhibitor therapy is enhanced.

The invention provides a culture method for improving immunity of fishes. The culture method comprises the following steps: S1, selection of culture points; S2, specification and layout of net cages; S3, selection and throwing of fish fries; according to the fry disinfection method disclosed by the invention, the fry are soaked and disinfected by using a compound disinfectant prepared from povidone iodine, polysorbate, citric acid and vitamin C in a specific proportion, so that pathogenic microorganisms on the surfaces and gill parts of fish bodies are effectively killed. According to the breeding management, the immunity of the fish body is comprehensively enhanced by feeding the fish with an immune conditioner composed of campesterol palmitate, immunomodulatory peptide, beta-glucan and astaxanthin in a specific proportion. According to the bottom mud management, the content of harmful substances is reduced by putting a bottom mud modifier composed of sodium molybdate, nitrifying bacteria, photosynthetic bacteria, tetrandrine and sodium alginate in a specific proportion, growth of pathogenic bacteria is inhibited, nutrient substance circulation is promoted, the water quality environment is optimized, and healthy growth of fry is promoted.

Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and / or immersing therein, a contact lens and / or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.

The invention belongs to the field of medicine, and relates to application of polydocanol in preparation of medicine for treating bromhidrosis through dispersion gridding subcutaneous multipoint continuous injection application, the polydocanol is a polydocanol injection, and each milliliter of the injection contains 5-30 mg of polydocanol. The invention further provides a medicine for treating bromhidrosis through dispersion gridding subcutaneous multipoint continuous injection application. The medicine comprises polydocanol and pharmaceutically acceptable auxiliary materials. The invention has the advantages of small trauma, simplicity and convenience in operation, high safety, longer treatment effect maintenance time and the like, and the long-term relieving effective rate is greater than 80%.

The invention relates to the technical field of aquaculture methods, in particular to a breeding method for preventing and treating ichthyophthiriasis of leiocassis longirostris fries. According to the technical scheme, the first system and the second system are adopted for sequential circulation treatment, and finally the third system is adopted for treatment, so that prevention and treatment of ichthyophthiriasis are achieved. The three systems are all subjected to heating treatment, and the first system contains sodium chloride and formaldehyde, so that rapid falling of insect bodies is promoted, and development of larvae is inhibited; the second system contains povidone iodine, so that body surface infection can be prevented; the third system consolidates the treatment effect; in the treatment process, unhatched cysts and dead polypides are discharged by changing water. A physical heating measure is adopted, so that osmotic stress of salinity on the freshwater fish is reduced. The adopted medicines are all easy to metabolize, are free of heavy metal ions, and have ideal ecological safety and food safety. According to the technical scheme, the technical problem that in the prior art, a safe and effective breeding method for preventing and treating the Leiocassis longirostris ichthyophthiriasis is lacked can be solved, and the method has ideal application and popularization prospects.

The present disclosure provides improved polymer compositions, such as acrylated gelatin polymer compositions. In certain embodiments, the improved polymer compositions can be used for delivering one or more therapeutic agents, such as cells, to a target therapeutic area, such as the eye of a subject. In certain embodiments, the improved polymer compositions are hydrogels which comprises acrylated gelatin (e.g., GelMA, GelAC, GelGA, GelGMA) or polymerically crosslinked derivatives thereof.

To provide modified or polymer conjugated MetAP2 inhibitors.SOLUTION: The present invention relates to methods of preventing, inducing, causing or increasing weight loss, treating obesity and / or treating metabolic syndrome utilizing the modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of improving insulin sensitivity and glycemic control, reducing insulin levels and / or improving leptin sensitivity utilizing the modified or polymer conjugated MetAP2 inhibitors.SELECTED DRAWING: Figure 1

The scar removing cream is prepared from the following raw materials in percentage by weight: 30 to 80 percent of silica gel component, 5 to 30 percent of solvent, 0.1 to 10 percent of emulsifying agent, 1 to 5 percent of thickening agent, 0.01 to 10 percent of extract / synergistic component, 0.1 to 20 percent of medicament component, 1 to 50 percent of moisturizing component, 0.01 to 0.1 percent of growth factor, 0.1 to 2 percent of other component, 0.01 to 0.5 percent of preservative and 0.1 to 2 percent of pH (Potential of Hydrogen) regulator. The traditional Chinese medicine composition has the effects of improving skin repair, whitening and diminishing inflammation, accelerates skin elasticity recovery and reduces scars.

Disclosed are a compound having anti-inflammatory activity, a preparation method therefor and the use thereof. According to the present invention, compounds 1-3, which have anti-inflammatory activity, are obtained from a metabolite of the Penicillium commune strain GIZ45-A73 for the first time. The metabolite of the Penicillium commune strain GIZ45-A73 of the present invention, which is obtained from the intestinal tract of Hepialus, is significantly different from metabolites of Penicillium commune strains from other sources, and is an important resource for discovering active metabolites.

The invention relates to an exosome-coated phosphorus-containing dendrimer nano-composite as well as a preparation method and application thereof. The nano-composite is prepared from exosome derived from mesenchymal stem cells, a hydroxyl-terminal phosphorus-containing dendrimer and quercetin. The exosome derived from the mesenchymal stem cells is used as a carrier, so that not only are good biocompatibility and anti-inflammatory activity achieved, but also the bioavailability of the phosphorus-containing dendrimer and quercetin can be improved. The phosphorus-containing dendrimer and quercetin exert anti-inflammatory and anti-oxidation effects by promoting microglial cells to be polarized to M2 type and removing active oxygen, so that neuronal cells are protected from apoptosis. The preparation method has the advantages of being simple, easy to operate, good in biocompatibility and the like, and the provided strategy has good development prospects and application values in treatment of Parkinson's disease or other neurodegenerative diseases.

A composition, usable for removing a biofilm and necrotic or infected tissues from skin lesions and lesions of the oral cavity, comprises methanesulfonic acid 99.0% and a proton acceptor. The proton acceptor is selected from the group consisting of: anhydrous sodium carbonate, 5-amino-2-mercaptobenzimidazole, ethylenediaminetetraacetic acid tetrasodium salt, sodium gluconate, sodium tartrate dihydrate, 2-mercapto-5-benzimidazole sodium sulfonate, dimethyl sulfoxide, polyethylene glycol 400, polyethylene glycol 600, silicon dioxide, tetraethoxysilane, and mixtures thereof. The aforesaid composition can be prepared in the form of a solution, gel or cream.

The invention discloses a mannitol-based covalent organic framework antibacterial material for specifically killing escherichia coli, and belongs to the technical field of biological medicines. Fesalen, mannitol and an accelerant are added into an organic solvent for a solvothermal reaction, an obtained product is washed and dried after the reaction is finished, and the mannitol-based covalent organic framework antibacterial material capable of specifically killing escherichia coli is obtained. The preparation method comprises the following steps: modifying a Salen monomer with iron to obtain an alen metal complex Fesalen, endowing Fesalen with good photo-thermal performance through metal modification, and then polymerizing with mannitol to prepare Fesalen-cof. Fesalen-cof can be used as an intelligent therapeutic agent, photo-thermal / POD cascade collaborative treatment is achieved, specific killing of escherichia coli is achieved, and a new thought is provided for precise sterilization.

Provided are a polylactic acid and a use of a copolymer thereof in the preparation of a drug for promoting nerve growth and repair. The molecular weight of the polylactic acid and the copolymer thereof is 400-300 k Da. The drug has the following effects: 1) promoting the growth of nerve cells and nervous tissue; 2) promoting repair of nerve cells and nervous tissue; and 3) treating or preventing a peripheral nerve injury, a spinal cord injury, peripheral neuropathy, and neuritis. The molecular weight is preferably 5000-100 k Da. It is found for the first time that the polylactic acid and the copolymer thereof have a protective effect on nerves, and can promote nerve growth and a nerve injury repair.

The invention provides an application of polylactic acid and a copolymer thereof in preparation of a medicine for promoting nerve growth and repairing, the molecular weight of the polylactic acid and the copolymer thereof is 400-300k Da, and the medicine has the following effects: 1) promoting growth of nerve cells and nerve tissues; 2) promoting the repair of nerve cells and nerve tissues; 3) treating or preventing peripheral nerve injury, spinal cord injury, peripheral neuropathy and neuritis; preferably, the molecular weight is in the range of 5000 to 100 k Da. The invention discovers that polylactic acid and the copolymer thereof have a protection effect on nerves for the first time, and can promote growth of the nerves and repair of nerve injury.

The present disclosure relates to a composition for balancing the immune system of a neonatal or infant subject, the composition comprising an effective amount of 2 '-fucosyllactose, 3-fucosyllactose, 3'-sialyllactose, 6 '-sialyllactose, and lactose-N-tetrasaccharide.

In some aspects, the present disclosure pertains to methods that comprise (a) performing a ring-opening polymerization of one or more types of amino acid N-carboxyanhydride (NCA) monomers that comprise at least one type of protected amino acid NCA monomer having a protected pendant amine group in the presence of an initiator compound to produce intermediate peptide compounds that comprise an amino acid chain having protected pendant amine groups covalently attached to a residue of the initiator and (b) deprotecting the intermediate peptide compounds to form final peptide compounds that comprise an amino acid chain having pendant amine groups covalently attached to the residue of the initiator.

The invention discloses a soluble double-layer microneedle patch loaded with an LL37-coated ZIF-8 and Prussian blue nano-enzyme pharmaceutical composition and application, and belongs to the technical field of biomedical materials. The soluble double-layer microneedle patch provided by the invention comprises a needle body layer and a backing layer, the needle body layer comprises a pullulan polysaccharide matrix, LL37 (at) ZIF-8 and a Prussian blue nano enzyme; and the backing layer comprises a pullulan polysaccharide matrix. According to the preparation method, pullulan, LL37 ZIF-8 and Prussian blue nano enzyme (PB) are combined for use, so that the soluble double-layer microneedle patch integrating efficient antibiosis, continuous antioxidation, healing promotion and biocompatibility can be obtained, and the application performance is good; and the preparation method has the advantages of mild reaction conditions, simple preparation, low raw material price, easiness in batch production and manufacturing and the like, and is easy for large-scale production.

Disclosed herein are compositions that can form a covering, layer, film, device, and / or prosthetic skin that can be comfortably worn to provide skin barrier function, skin hydration and therapeutic and aesthetic benefits. Provided herein are novel compositions that have low tackiness and form quickly, resulting in a wearable, comfortable (maintains temperature and humidity), breathable, thin, optically invisible, cosmetically elegant, flexible, stretchable, elastic and body-movement conforming, yet long-lasting covering, layer, film, device, and / or prosthetic skin on the skin or any other body surface. Provided herein are novel compositions that can form a covering, layer, film, device, and / or prosthetic skin that works for extended periods in excess of about 24 hours, while retaining function during and after exercising, showering and swimming (in sea-water, fresh water and chlorinated water), steam room (heat at high humidity), and sauna (heat at low humidity).

The invention provides an application of polyoxyethylene particles in preparation of a biocompatible preparation for promoting digestive tract mucosal injury repair. The weight-average molecular weight of polyoxyethylene is 1 million Dalton to 7 million Dalton; the average particle size of the polyoxyethylene particles is 0.5 [mu] m to 2000 [mu] m; after the preparation is applied to the injured wound surface of the digestive tract mucosa, colloid covering the injured wound surface of the digestive tract mucosa is formed. The colloid can effectively protect digestive tract mucosa, avoid side effects caused by drug treatment of digestive tract mucosa injury, and provide an effective repair protection barrier for a digestive tract ulcer wound surface or a mucosa injury wound surface, so that the repair of the wound surface is promoted.

Described herein are nitric oxide-releasing compositions. In one aspect, the nitric oxide releasing polysiloxane comprises a polysiloxane backbone with one or more nitric oxide releasing moieties pendant to the polysiloxane backbone. The nitric oxide-releasing compositions possess antibacterial properties with respect to both Gram-positive and Gram-negative bacteria. The ease of synthesis and excellent antibacterial effects against both Gram-positive and Gram-negative bacteria without resistance and serious leaching concerns makes the nitric oxide-releasing compositions useful as lubricants for medical devices and other articles where it is desirable to reduce or prevent bacterial infection.

Simethicone and a preparation method therefor, and an emulsion comprising simethicone and a preparation method therefor. Simethicone with appropriate viscosity, strong defoaming capacity, no sedimentation, and good fluidity is obtained by using a specific ratio of dimethicone and silicon dioxide combined with the specific preparation method. In addition, the emulsion prepared by adopting an emulsifier and a thickener features good defoaming capacity, moderate viscosity, and good stability.

The invention relates to a pharmaceutical composition in the form of orodispersible powder comprising simeticone and alverine citrate, as well as to the method for manufacturing same; to a pharmaceutical composition in dry form containing simeticone and to the method for manufacturing same; and to a pharmaceutical composition in the form of grains comprising alverine citrate and to the method for manufacturing same. The pharmaceutical composition comprising a mixture of alverine citrate and simeticone according to the invention comprises grains composed of simeticone adsorbed onto a powdered solid support, granules containing grains containing alverine citrate, wherein the outer surface of these grains is coated with a film made of a masking agent, and pharmaceutically acceptable excipients comprising at least one flavouring, and / or at least one acidifier, and / or at least one sweetener, and / or at least one lubricating / anti-aggregating agent, and / or at least one filler. The invention is intended for use in the pharmaceutical industry.

In some aspects, the present disclosure pertains to methods that comprise (a) performing a ring-opening polymerization of one or more types of amino acid N-carboxyanhydride (NCA) monomers that comprise at least one type of protected amino acid NCA monomer having a protected pendant amine group in the presence of an initiator compound to produce intermediate peptide compounds that comprise an amino acid chain having protected pendant amine groups covalently attached to a residue of the initiator and (b) deprotecting the intermediate peptide compounds to form final peptide compounds that comprise an amino acid chain having pendant amine groups covalently attached to the residue of the initiator.

The invention relates to the technical field of medical dressings, and discloses a scar repair gel containing recombinant mussel mucin and a preparation method thereof. The scar repair gel is prepared from the following components in percentage by mass: 0.01 to 0.2 percent of recombinant mussel mucin, 0.4 to 0.8 percent of a thickening agent, 6 to 15 percent of a compound emulsifier, 1 to 2 percent of a pH regulator, 20 to 40 percent of silicone, 0.1 to 0.3 percent of a preservative and the balance of water, wherein the silicone comprises polydimethylsiloxane, a polydimethylsiloxane cross-linking agent and decamethylcyclopentasiloxane. The scar repair gel containing the recombinant mussel mucin has good film-forming property, forms a moisturizing barrier on the surface of a wound, can inhibit formation of hyperplasia scars, reduces pruritus in the wound healing process, reduces generation and deposition of melanin, and has the effects of repairing scars and repairing scars. The comfort of a patient in the use process and the compounding stability of the mussel mucin and silicone gel system are effectively improved.