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179 results about "Class iii" patented technology

Controlled regional oral delivery

A composite formulation has been developed for selective, high efficacy delivery to specific regions of the mouth and gastrointestinal tract. The formulation is typically in the form of a tablet or capsule, which may include microparticles or beads. The formulation uses bioadhesive and controlled release elements to direct release to specific regions, where the drug is absorbed in enhanced amounts relative to the formulation in the absence of the bioadhesive and / or controlled release elements. This is demonstrated by an example showing delivery of gabapentin with a greater area under the curve (“AUC”) relative to the FDA reference immediate release drug, i.e., the AUC of the composite bioadhesive formulation is greater than 100% of the AUC of the immediate release drug. In the preferred embodiments, the formulation includes drug to be delivered, controlled release elements, and one or more bioadhesive elements. The bioadhesive polymer may be either dispersed in the matrix of the tablet or applied as a direct compressed coating to the solid oral dosage form. The controlled release elements are selected to determine the site of release. The bioadhesive components are selected to provide retention of the formulation at the desired site of uptake and administration. By selecting for both release and retention at a specific site, typically based on time of transit through the gastrointestinal tract, one obtains enhanced efficacy of uptake of the drug. This is particularly useful for drugs with narrow windows of absorption, and drugs with poor solubility such as the BCE class III and class IV drugs.
Owner:VAUNNEX

Gastrodia tuber imitative wild sexual reproduction breeding technique

The invention discloses an imitative wild sexual reproduction and breeding technique of gastrodia tuber. Main steps comprises that breeding is carried out to get mature gastrodia tuber seeds and good sprouting strain, mature class III shoestring fungus is adopted as production seed, which is planted under a natural hillside forest that is with over 80 percent of shade density and in which wild gastrodia tuber grows and is distributed; artificial mixed germination strain is adopted; room temperature is controlled so as to produce germination strain with seed; sexual reproduction, breeding and planting time is selected between June and August; the breeding technique is also suitable for field breeding. The invention has the advantages that: 1. bad factors resistance property of sexual reproduction and breeding of gastrodia tuber is improved. 2. Gastrodia tuber seeds are germinated to lead the growth cycle of protocorms to be a time slice that is basically matched with an animated period of the shoestring fungus; inoculation rate and survival rate of the protocorms are increased. 3. Raw materials are obtained locally, thus reducing cost; sustainable development of non-pollution gastrodia tuber planting industry is promoted in ecological agriculture forests. 4. The small site breeding method enhances competitor infection resistance of the gastrodia tuber seed.
Owner:贵州九龙天麻有限公司
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