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Provided herein are compositions and formulations suitable for the treatment of gastrointestinal disorders. Also provided are methods for treating, preventing, or alleviating disorders of the gastrointestinal tract, for example, those involving the esophagus.

A closure system for managing rectal or anal incontinence, having a shaft element, with a distal end and a proximal end and at least one lumen. An inflatable intrarectal balloon includes a flexible, extensible plastic material with a distal end and a proximal end, each of which is attached to the shaft element in a securely bonded and sealed fashion. The intrarectal balloon communicates with the at least one lumen via a perforation in the wall of the shaft element and can be acted on with a filling medium via the lumen. An anchoring element serves as a buttress, which is attached to the shaft element spaced apart from the intrarectal balloon on its proximal side, in the direction toward the proximal end of the shaft element. The distal end of the intrarectal balloon is attached to the shaft element, the balloon being invaginated in the direction toward the proximal end of the balloon in such a way that the intrarectal balloon attached with its two ends to the shaft element, as it is filled with a filling medium, executes a rolling motion from the distal end of the shaft element toward the proximal end of the shaft element.

A microcatheter system that allows for vascular infusion into retinal veins for extended periods of time. The microcatheter system includes a flexible cannula that is inserted into the retinal vein lumen and that remains stably within the retinal vein lumen without being held by a robot, micromanipulator or similar holding devices. The microcatheter system is particularly suitable for the treatment of retinal venous occlusive disease.

A prosthesis for facet joints of the spinal column includes a bearing piece and a guide rod. The bearing piece includes a pressure plate that is configured for resting on an articular surface of the vertebra and, on the opposite side, a bearing insert which has an articular surface configured for interacting with an articular surface of an adjacent vertebra. The guide rod is secured on the bearing piece by means of a pivot joint. The bearing forces are transmitted to the vertebra via the pressure plate. In this way, the guide rod can have a narrow configuration, such that a slit excavated in the vertebra for receiving the guide rod can also be made narrow to permit a simple and reliable implantation technique which at the same time is gentle on the bone substance.

An implantable biocompatible expander suitable for implantation into a urinary duct, comprises an elongated sinusoidal ring comprising at least two proximal prongs and at least two distal prongs, wherein the expander is resiliently deformable from a relaxed radially expanded orientation to a radially contracted orientation suitable for transluminal delivery through the urinary duct. The expander is configured to exert an outward radial force against a wall of the urinary duct when in-situ within the urinary duct. In particular, the expander is suitable for treatment of benign prostatic hyperplasia and configured for implantation into the prostatic urethra between, and substantially spanning the prostatic urethra between, the bladder neck and external sphincter.

Sprayable, anhydrous and physically/chemically stable dermatological/pharmaceutical compositions, well suited for the treatment of a variety of dermatological disorders, notably psoriasis, contain: a) a therapeutically effective amount of a solubilized corticord; notably clobetasol propionate; b) a therapeutically effective amount of a solubilized vitamin D derivative, notably calcitriol; c) an alcohol phase; d) at least one volatile silicone; and e) a non-volatile oily phase which comprises one or more oils; formulated into f), a sprayable and topically applicable, dermatologically/pharmaceutically acceptable vehicle therefor.

The present invention provides a buffered non-flowing composition suitable for the treatment of bacterial vaginosis. The composition includes metronidazole in a concentration of about 0.50% (w/w) to about 1.50% (w/w). The metronidazole is present together with a buffer system in a physiologically tolerable medium. The buffer system provides an acidic buffered pH value for the composition in the range of about 5.0 to about 6.0. The present invention also provides for a method for inhibiting a microorganism. The method includes contacting a microorganism with an effective amount of the composition of the present invention, for a period of time effective to inhibit the microorganism. The present invention also provides for a method for treating bacterial vaginosis in a human patient. The method includes intravaginal administration to a patient in need of such treatment an effective amount of the composition the present invention. The composition is introduced into the vagina at least once a day for a time period of at least one day.

Silicon carbide foam useful as a catalyst support has a BET specific surface area of at least 5 m2/g, and a compression strength exceeding 0.2 MPa. The foam is prepared by impreganting an organic foam with a suspension of silicon in a resin containing a cross-linking agent, incompletely cross-linking the resin, carbonizing the foam and resin, and carburizing the silicon.

A sleeve is provided for placing over a flexible endoscope. The sleeve has a port between its distal and proximal openings and the port is connected to a vacuum source. Once the endoscope is retracted proximal to the suction port, the sleeve's proximal opening is sealed off and the entire sleeve is turned into a suction lumen. Devices and methods in accordance with the invention provide improvement in removing materials from body cavities, especially in removing stones from the upper urinary tract.

Biomaterial having a multi-dimensional structure and comprising differentiated MSCs tissue and demineralised bone matrix, wherein said demineralised bone matrix is dispersed within the differentiated MSCs tissue, method for producing the same and use thereof.

The modular waste water treatment system receives waste water from a waste water source containing organic waste and produces a treated water effluent. The modular system includes bioreactors and a bioreactor support module. The bioreactors receive a waste water mixture from the bioreactor support module and produce treated water substantially free of organic waste. The bioreactor support module is a transportable unit fabricated upon a frame adapted for transport by a truck upon a public roadway. The bioreactor support module includes items of equipment needed for conditioning waste water for intake by the bioreactors, items of equipment for receiving, processing and discharging treated water from the bioreactors and may include other items of equipment for receiving and processing other byproducts from the bioreactors. The transportable bioreactor support module is sized to support the operation of between one and preferably as many as six bioractors. Accordingly, the modular waste water treatment system can be fabricated off site in a controlled shop environment, transported to a site, placed at a site and even later expanded to include additional bioreactors for increased capacity with a minimum of cost, time and effort.

A system for washing, dipping, and drying animals includes a water and fume retaining stall, a hood for covering the stall, and an air circulating unit for supplying warm air and for exhausting fumes, including fumes associated with flea and tick formulas used in dipping processes. A double-walled shell coupled with a base unit housing mechanical utilities serves as the stall. Water supply and wastewater drainage systems are coupled for direct communication with a tub, sink or laundry connection, and an associated drain. Fluids can be recycled and discharged to the stall, for reuse, and can be mixed with various solutions, including dipping solutions. The stall, hood and air circulating unit can be modular, for versatility. Steps can be provided to facilitate ingress and egress by the animal. A stool can be provided for the user, and the stall can be elevated, to promote user comfort.

A femoral stem 2 for artificial hip joint is provided that is capable of tightly fixing a greater trochanter and is suitable for treatment of transcervical fracture where it is necessary to fix the greater trochanter. The femoral stem 2 comprising: a stem member 20 including a distal part 21 of the stem member which is inserted in a medullary cavity of a femur and fixed therein and a proximal part 22 of the stem member which has a neck 26 for fixing an artificial head and is positioned at a proximal end of the distal part, the distal part and the proximal part being integrated or separable; a plate fixing portion 36 which is detachably attached at a top of the proximal part; and a greater trochanter plate 3 for depressing the greater trochanter 71, the greater trochanter being fixed to the plate fixing portion 36 at a certain angle or fixed to the plate fixing portion so as to adjust an angle. Since the greater trochanter plate 3 is fixed onto the femoral stem 2 of the present invention, the greater trochanter is tightly fixing and thus the fixation can be stabilized. Furthermore, since the greater trochanter plate 3 is fixed at the top of the proximal part 22, the greater trochanter plate 3 covers the top of the greater trochanter 71 when the greater trochanter 71 is fixed. Therefore upward displacement of the greater trochanter by a gluteus medius musculus can be effectively suppressed.

The invention discloses a method from extracting amylase from liquorice and application thereof. The method comprises the following steps: a. dried liquorice is ground; b. the ground liquorice is put into an extraction tank, petroleum ether is added for reflowing and degreasing, and then filtered out to obtain degreased residue; c. the residue is added with distilled water for extraction in normal termperature, repeatedly poached and extracted for three times, and triple extraction solutions are combined; d. the extraction solution is decompressed and concentrated to cause the volume of the solution to be the liquorice powder in the step a, thus obtaining a concentrated solution; e. a concentrated solution is added into the concentrated solution in the step d, and then the concentrated mixed solution stands overnight and precipitates; f. the concentrated mixed solution is centrifugalized to obtain the precipitation, dried, and then washed with absolute ethyl alcohol, acetone and aether after is extracted by a Sevag method; g. semi-permeable membrane with the interception molecular weight of 1000-10000 is used for dialyzing in water, the liquorice amylase is obtained by freezing and drying. The liquorice amylase is applied to the preparation of medicine treating or preventing osteoarthritis. The liquorice amylase has definite active ingredient, definite healing effect and no toxic side effect and the extraction method is easy to be implemented.

The present invention provides defined serum-free cell culture media useful in culturing fibroblasts, especially articular chondrocytes, that avoid problems inherent in the use of serum-containing media. The defined media comprise platelet-derived growth factor (PDGF), chemically defined lipids, oncostatin M (OSM), interleukin-6 (IL-6), leukemia inhibitory factor (LIF), or combinations of these compounds. In another aspect, the present invention also provides tissue culture methods that comprise incubating chondrocytes in the defined serum-free media. The methods enhance attachment and proliferative expansion of chondrocytes seeded at low density while maintaining their redifferentiation potential.

The invention relates to a dripping pill for treating abdominal distention, abdominal pain, apocleisis and constipation, as well as its preparing process. The dripping pill is prepared from main ingredients of four medicinal herbs including banksia rose, bitter orange, areca seed and spicebush root, base material of polyethylene glycol, condensation agent of liquid paraffin or dimethicone or vegetable oil.

The present invention provides a corrosion inhibitor composition comprising:

• a carrier;
• at least one compound of formulae (II)-(VII) or a salt or quaternised derivative thereof: