101results about How to "Preserving function" patented technology

An endoscope assembly with a main imaging device and a first light source is configured to provide a forward view of a body cavity, and further includes a detachable imaging device with an attachment member engageable with the distal end region of the endoscope, a linking member connected to the attachment member, and an imaging element with a second light source, wherein the detachable imaging device provides a retrograde view of the body cavity and the main imaging device. Light interference is reduced by using polarizing filters or by alternating the on / off state of the main imaging device, the first light source, the imaging element and the second light source so that the main imaging device and first light source are on when the imaging element and second light source are off and the main imaging device and first light source are off when the imaging element and second light source are on.

A golf club head comprising a channel and an expandable weight that can be removably fixed at any point within the channel is disclosed herein. The channel preferably is disposed on the sole and extends from a heel side of the golf club head, around a rear side, and ends at a toe side of the golf club head. This channel is not constrained to a planar arc, but instead twists as it extends around the golf club head so that it follows the contours, and preserves the aesthetics, of the golf club head. The expandable weight preferably is trapped within the channel so that it cannot fall out of the channel during use, and includes an anti-rotation feature so that it does not twist within the channel and cause an undesirable rattling noise.

An endoscope includes a detachable wireless imaging device and an insertion tube having a distal end region. The attachment of the detachable wireless imaging device detachably attaches the detachable wireless imaging device to the distal end region of the insertion tube.

This patent discloses compositions and methods of use thereof to normalize the blood glucose levels of patients with type 2 diabetes. It relates particularly to a plasmid comprising a chicken β actin promoter and enhancer; a modified GLP-1 (7-37) cDNA (pβGLP1), carrying a furin cleavage site, which is constructed and delivered into a cell for the expression of active GLP-1.

Surgical repairs of torn or ruptured tendons and ligaments are made by re-fastening the torn or ruptured tendon or ligament with a biocompatible or bioabsorbable hook-and-loop fastener.

Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications.

A golf club head comprising multiple means of adjusting the location of the center of gravity, and the bias, is disclosed herein. In a preferred embodiment, the golf club head comprises a non-metal medallion comprising a channel that is affixed to one of the crown and the sole, a slidable weight sized to fit within the channel, and a cover that attaches to the medallion and locks the slidable weight within the channel at a location selected by a user. The cover preferably includes at least one cutout so that the slidable weight is at least partially visible to the user when it is locked within the channel. The cover also includes additional cutouts that receive protrusions extending from the medallion to more securely attach the cover to the medallion.

A golf club head comprising a means for adjusting the location of the center of gravity, and the bias of the golf club head, is disclosed herein. In particular, the golf dub head of the present invention comprises a channel that includes a track. A slidable weight is movable along the track and is reversibly affixed to various locations along the track with a mechanical fastener. The track has a narrow end by which the slidable weight is threaded onto the track, and the narrow end is covered with a stopper to prevent the weight from disengaging from the track, and thus the channel.

A golf club head comprising a slidable weight for adjusting the location of the golf club head center of gravity, as well as the golf club head bias, is disclosed herein. In particular, the golf club head, which may be a wood or iron-type head, comprises a pair of rails extending along at least one surface, such as a rear surface of an iron type head or a channel disposed in a wood-type head, and a slidable weight comprising a pair of grooves sized to receive the rails. In some embodiments, an applique or one or more clips are applied over or to the rails to prevent the weight from disengaging from the golf club head.

Aryl GPR119 agonists are provided. These compounds are useful for the treatment of diabetic diseases, including Type II diabetes and other diseases associated with poor glycemic control.

A golf club head comprising a channel or a pair of parallel rails and a slidable weight assembly that can be removably fixed at any point within the channel or to the rails is disclosed herein. The slidable weight assembly preferably comprises a weight portion and base that can be turned 45 to 90 degrees to reversibly fix the slidable weight assembly within the channel or to the rails.

A golf club head comprising features for adjusting the location of the center of gravity along all three axes is disclosed herein. In particular, the head comprises a body with a channel in its sole, at least one slidable receptacle sized to engage the channel, and a slidable weight. The channel preferably comprises a first floor and a pair of rails, while the slidable receptacle comprises a first base portion, a first bolt, and a first upper portion with a slot having a second floor and another pair of rails. The first upper and base portions grip the channel's rails when the first bolt is tightened. Similarly, the slidable weight comprises a second upper portion, a second base portion, and a second bolt, and the second upper and base portions grip the slot's rails when the second bolt is tightened.

A golf club head comprising a means for adjusting the location of the center of gravity is disclosed herein. In particular, the golf club head of the present invention comprises a first channel that includes a rail extending upwards from its floor and a second channel including a groove extending into its floor. The second channel intersects the first channel at a junction, and a slidable weight comprising a contoured body portion, one or more mechanical fasteners, and a clamping structure that engages the rail or the groove when the one or more fasteners are tightened is disposed within at least one of the channels. The slidable weight can be moved into either of the channels without being removed from the golf club head and indexed, thus saving a golfer time during adjustment.

A golf club head comprising a channel and an expandable weight that can be removably fixed at any point within the channel is disclosed herein. The channel preferably is disposed on the sole and extends from a heel side of the golf club head, around a rear side, and ends at a toe side of the golf club head. This channel is not constrained to a planar arc, but instead twists as it extends around the golf club head so that it follows the contours, and preserves the aesthetics, of the golf club head. The expandable weight preferably is trapped within the channel so that it cannot fall out of the channel during use, and includes an anti-rotation feature so that it does not twist within the channel and cause an undesirable rattling noise.

Described is a set of at least two annuloplasty devices having a particular size that corresponds to an inter-trigonal or inter-commissural distance of a heart valve annulus, wherein the at least two annuloplasty devices have different anterior-posterior ratios. Also, described is a kit for annuloplasty repair of a heart valve annulus including a plurality of annuloplasty devices each comprising one of a plurality of different sizes, wherein the different sizes each correspond to a different inter-trigonal or inter-commissural distance of a heart valve annulus, and for each of the plurality of different sizes there are at least two devices each having the same size but having different anterior-posterior ratios. Additionally, a method of choosing an annuloplasty device for implantation in a valve annulus is described.

A system-on-chip (SOC) includes a power down circuit. Within the SOC are several circuit blocks, each of them operating responsive to a local clock signal. A system clock is coupled to the circuit blocks for providing a system clock signal that functions as the local clock signal for selected circuit blocks. A power control manager provides a signal that at least partially determines whether the system clock will act as the local clock for some of the circuit blocks. Within the circuit blocks is a shutdown circuit that selectively prevents the system clock signal from functioning as the local clock signal in those circuit blocks that receive the shutdown signal, but the shutdown circuit only operates after both the signal to shutdown is received from the power control manager and after the circuit block has, in fact, shutdown.

A circuit is provided which protects the measuring input of an impedance tomograph from damage due to overvoltage. A resistor capacitor (RC) series connection is provided as a protective circuit at the measuring input.

An implantable biocompatible expander suitable for implantation into a urinary duct, comprises an elongated sinusoidal ring comprising at least two proximal prongs and at least two distal prongs, wherein the expander is resiliently deformable from a relaxed radially expanded orientation to a radially contracted orientation suitable for transluminal delivery through the urinary duct. The expander is configured to exert an outward radial force against a wall of the urinary duct when in-situ within the urinary duct. In particular, the expander is suitable for treatment of benign prostatic hyperplasia and configured for implantation into the prostatic urethra between, and substantially spanning the prostatic urethra between, the bladder neck and external sphincter.

A golf club head comprising a channel and a sliding weight that can be reversibly fixed at any point within the channel is disclosed herein. The channel preferably is disposed on the sole and extends from a heel side of the golf club head, around a rear side, and ends at a toe side of the golf club head. This channel is not constrained to a planar arc, but instead twists as it extends around the golf club head so that it follows the contours, and preserves the aesthetics, of the golf club head. The slidable weight comprises a base portion and a first cap, and a second cap that has the same dimensions as, and is interchangeable with, the first cap is disposed in a pocket in the sole proximate the face of the golf club head.

A golf club head comprising multiple means of adjusting the location of the center of gravity, and the bias, is disclosed herein. In a preferred embodiment, the golf club head comprises a non-metal medallion comprising a channel that is affixed to one of the crown and the sole, a slidable weight sized to fit within the channel, and a cover that attaches to the medallion and locks the slidable weight within the channel at a location selected by a user. The cover preferably includes at least one cutout so that the slidable weight is at least partially visible to the user when it is locked within the channel. The cover also includes additional cutouts that receive protrusions extending from the medallion to more securely attach the cover to the medallion.

A vacuum pump for supplying a machine assembly with a negative pressure includes a housing and a housing cover surrounding a delivery chamber. The delivery chamber includes a low-pressure region having a working inlet connected to the assembly, and a high-pressure region having a working outlet. A delivery member moveable within the delivery chamber, which, when moved, suctions air into the delivery chamber through the working inlet and expel it at an increased pressure through the working outlet. An outlet valve is arranged at or downstream or the working outlet and at least makes it difficult for air to flow back into the delivery chamber. The delivery chamber is connected to the external environment of the vacuum pump via a ventilating connection in order to establish at least partial pressure equalization with the external environment when the delivery member is stopped and a negative pressure prevails in the delivery chamber.

Still further provided is a fuel cell with an anode compartment and a cathode compartment comprising: in the anode compartment, an anode electrode and, integrated into biocompatible membrane tethered to the anode electrode, a redox enzyme that can receive electrons from an electron carrier; in the cathode compartment, a cathode electrode which, when a conductive pathway to the first electrode is formed, is effective to convey the electrons to an electron acceptor composition in the cathode compartment; and a barrier separating the anode compartment from the cathode compartment but effective to convey protons from the anode compartment to the cathode compartment.

This invention is in the area of dosage formulations and methods of administering a CDK4 / 6 inhibitor for the transient protection of healthy cells, and in particular hematopoietic stem and progenitor cells (HSPC), from damage associated with DNA damaging chemotherapeutic agents in subjects undergoing DNA damaging chemotherapeutic therapies for the treatment of proliferative disorders. In one aspect, improved protection of healthy cells is disclosed using a dosage that provides desirable pharmacokinetic and pharmacodynamic characteristics, including AUC, Tmax, Cmax, dosage-corrected AUC, and dosage-corrected Cmax. In another aspect, a method of treating a subject undergoing chemotherapy for the treatment of a CDK 4 / 6-replication independent cellular proliferation disorder by administering Compound 1 is provided.

Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.

A golf club head comprising a slidable weight for adjusting the location of the golf club head center of gravity, as well as the golf club head bias, is disclosed herein. In particular, the golf club head, which may be a wood or iron-type head, comprises a pair of rails extending along at least one surface, such as a rear surface of an iron type head or a channel disposed in a wood-type head, and a slidable weight comprising a pair of grooves sized to receive the rails. In some embodiments, an applique or one or more clips are applied over or to the rails to prevent the weight from disengaging from the golf club head.

A muzzle brake of a weapon or a weapons system for small- and medium-calibre weapons, that has a reduced outer signature with respect to heat and / or propellant gas emissions is provided. For this purpose, the propellant gas emerging from the barrel is diverted to the gas outlet openings of the muzzle brake in order to impinge on them to absorb the recoil, and is then made to pass further to the rear, and thereby cooled in a device.

A ball-and-socket joint has a pivot pin accommodated rotatably and tiltably with a spherical joint area in a bearing shell. The bearing shell is in turn arranged in the recess of a joint housing. A closing ring fixes the bearing shell in the joint housing in the axial longitudinal direction of the pivot pin by at least one surface pair. Corresponding to a first solution variant, an intermediate element made of an elastic material may be arranged between the corresponding contact surfaces of the surface pair on the bearing shell and the closing ring. As an alternative an insert element may be arranged between the outer contour of the bearing shell and the bottom area of the recess, wherein at least one intermediate element made of an elastic material is arranged between the outer surface of the insert element and the corresponding inner surface of the recess. The requirement imposed on the dimensional accuracy of the ball-and-socket joint components can be substantially reduced due to these solution variants, which contributes to a reduction of the manufacturing costs.

The present invention relates to the unexpected finding that vessels smaller than even the smallest arteries (i.e. arterioles) thicken, become dysfunctional and cause end organ damage to tissues as diverse as the brain and the kidney. This invention provides a method to improve the structure and function of arterioles and preserve the function of end organs such as the brain and kidney. In certain embodiments, the methods involve administering to a human having thickened arterioles in brain, kidney or alveoli a peptide that ranges in length up to 30 amino acids, and that comprises a class A amphipathic helix, and bears at least one protecting group.