170 results about "Acidosis" patented technology

The present invention provides compositions and methods for protecting tissues and organs from damage during transplantation or from acute ischemia due to, e.g., injury or surgery. The compositions protect the tissue or organ from acidosis, oxidative damage, ischemia and repurfusion injury while the organ is isolated from the normal circulation or receives inadequate arterial flow.

The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.

The present invention relates to a vaccine for the prevention of lactic acidosis in a vertebrate, said vaccine comprising at least one isolated microorganism, or fragment or fragments thereof, wherein said microorganism is capable of producing lactic acid within the gut of said vertebrate, and wherein said microorganism is selected from the group consisting of: Clostridium-like species, Prevotella-like species, Bacteroides-like species, Enterococcus-like species, Selenomonas species, non-dextran slime producing Streptococcus species and non-slime producing lactic acid bacterial isolates.

Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.

The invention relates to a total mixed ration for high producing dairy cows, which is characterized in that: the total mixed ration is formed by the following ingredients in part by weight: 9-13 parts of feed supplement, 24-28 parts of ensile, 2-5 parts of Chinese wildrye, 1-3 parts of bur clover, 1-3 parts of dried brewer's grains, 1-2 parts of whole cottonseed, 1-3 parts of beet pellet grains and 1-2 parts of molasses. The total mixed ration for the high producing dairy cows has the advantages that: the nutritional and metabolic diseases, such as rumen acidosis, parturient paresis and ketosis, easily occurred in the traditional feed feeding method are solved; the milk production potential of the high producing dairy cows can be developed, the feed can be saved, and the cost can be lowered, so that the economic benefits of the dairy cows are remarkably improved; and with the adoption of the total mixed ration and the combination of a scientific cultivation and management technique, the milk yield is averagely increased by 2Kg per cow every day, and the milk production life is increased by 2-3 parities.

Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.

Acid compositions for ruminants containing a plurality of acid-neutralizing salts with pKa's effective at different ruminant gastrointestinal pH ranges and an active probiotic culture capable of stimulating the growth and concentration of beneficial acid-consuming rumen microorganisms. Methods for preventing clinical and sub-clinical acidosis in ruminants with the acid-neutralizing salts and feed compositions to which the acid-neutralizing salts have been added are also disclosed.

The invention discloses a high-protein mineral nutrition block for fattening sheep and a preparation method of the high-protein mineral nutrition block. The high-protein mineral nutrition block for fattening sheep is prepared from the following components in percentage by weight: 5-8 percent of calcium hydrophosphate, 3-8 percent of sodium hydrogen carbonate, 1-3 percent of magnesium oxide, 3-8 percent of sodium chloride, 0-10 percent of starch, 6-10 percent of ammonium chloride, 0-10 percent of puffing urea, 15-25 percent of molasses, 30-40 percent of puffing albumen powder, 2-5 percent of vitamin trace element addictives for breeding sheep, 2-3 percent of composite microecological preparations, 1-3 percent of lysine, 0.5-1.5 percent of methionine and 0.5-1.5 percent of tryptophan. The block prepared by using the method has high content of crude protein, and the content can be up to more than 45 percent, so that three limiting amino acids required by rumen microorganism and the fattening sheep are intensified; besides addition of mineral elements required by the growth of the fattening sheep, rumen regulating agents are also added so as to prevent rumen acidosis caused by massively feeding high-energy fermented feed.

Improved ruminant feeds are provided which include a pH-adjusted first ingredient selected from the group consisting of ruminant-edible, initially low pH commercial byproducts and initially low pH grain or forage-derived products, combined with a second ingredient comprising a high digestive efficiency feed grain such as flaked corn. An improved process (10) for the production of a ruminant feed (50) as an adjunct to a fuel ethanol plant is also provided wherein starch-bearing grain (12) is processed to yield ethanol (30) and whole stillage (32). The whole stillage (32) is then treated to remove water and to yield a wet distiller's grain product (WDG) (38). The pH of the WDG (38) is then elevated (46) by the addition of base to a pH of from about 5-8, and the pH-adjusted WDG (46) is optionally dried (47) and combined with a high digestive efficiency feed grain (HDEG) such as flaked grain (48). The ruminant feeds (50) of the invention do not generate low rumen pH levels when consumed, and thus avoid rumen acidosis and related problems.

A method is disclosed for using fructose-1,6-diphosphate (FDP) to reduce and prevent two very serious problems caused by surgery that requires cardiopulmonary bypass. Before bypass begins, a liquid that contains FDP is intravenously injected into the patient, preferably over a period such as about 10 to 30 minutes, to allow the FDP to permeate in significant quantity into the heart and lungs while the heart is still beating. FDP can be added to the cardioplegia solution that is pumped through the heart to stop the heartbeat, and / or during bypass. This treatment was found to reduce two very important and serious problems that have unavoidably plagued CPB surgery in the past, which are: (1) elevated levels of pulmonary vascular resistance (PVR), which includes pulmonary hypertension; and (2) high occurrence rates for atrial fibrillation. Prior to this discovery, there has never been any satisfactory treatment which could reduce the severity and occurrence rates for these two major problems. FDP also can be co-administered in this manner, along with (1) a buffering or alkalizing agent that counteracts acidosis, such as sodium bicarbonate or THAM, and / or (2) a drug that reduces the formation of lactic acid, such as dichloroacetate.

A method for facilitating postoperative awakening of patients from anesthesia does not depend on the experience of anesthesiologists. Also provided are an anesthesia arousal composition for use in this method and a preparation containing a bicarbonate ion that facilitates awakening from anesthesia. Specifically, the anesthesia arousal composition is provided in the form of infusion fluid. The method for controlling and facilitating awakening from anesthesia involves administering the anesthesia arousal composition. The present invention preferably provides an anesthesia arousal composition or an acidosis-correcting composition containing sodium bicarbonate as a major component that serves as a source of the bicarbonate ion, along with each or a combination of another electrolyte, glucose and an amino acid.

According to the present invention, there is provided a delivery vehicle including sickle red blood cells carrying a moiety. The moiety can be any type of diagnostic or therapeutic agent. The present invention further provides for a method of diagnosing systemic hypoxia, acidosis, or hypertonicity by administering sickle red blood cells to a patient and detecting the location of the sickle red blood cells. Additionally, the present invention provides for a method of therapeutic treatment of systemic hypoxia, acidosis, or hypertonicity by administering sickle red blood cells to a patient. Further, the present invention provides for a delivery vehicle that specifically localizes or concentrates at systemic hypoxia, acidosis, or hypertonicity areas. The delivery vehicle is used in diagnosing and therapeutically treating these areas of hypoxia, acidosis, or hypertonicity also. The present invention further provides for a method of making the delivery vehicle described herein.

The invention discloses a cross-linked hemoglobin preparation method, wherein the preparation method comprises the following steps: a, diluting deoxidized hemoglobin, and adding the diluted deoxidizedhemoglobin into an anaerobic reactor; b, arranging an atomizer at the top of the anaerobic reactor, adding a cross-linking agent into the reactor through the atomizer, and carrying out a cross-linking reaction; and c, adding a reducing agent to terminate the cross-linking reaction, and removing the unreacted cross-linking agent and the terminating reducing agent in an ultrafiltration liquid changing manner to obtain the cross-linked hemoglobin. The cross-linked hemoglobin prepared by the preparation method contains low contents of macromolecules (greater than 500 kD) and micromolecules (lessthan 64 kD); by adding the cross-linked hemoglobin into organ perfusate, the phenomena of organ acidosis and lysosomal enzyme activation adverse consequences caused by lack of an oxygen carrying agentin conventional perfusate and cell damage caused by excessive free radicals generated during reperfusion can be solved, and the perfusate is quite simple and convenient to prepare, store, transport and use.

A ruminant mineral feed additive for dairy cattle and ruminant animals includes a unique combination of zeolite and dolomitic hydrate mineral fines that are prilled and hydrothermally reacted to produce a valuable dietary supplement for control of acidosis.

The invention discloses a Chinese herbal medicine feed additive for improving the beef quality and a preparation method of the Chinese herbal medicine feed additive. The Chinese herbal medicine feed additive comprises, in parts by weight, 36-70 parts of refined traditional Chinese medicine powder, 0.2-0.7 part of a flavoring agent, 0.38-0.56 part of microelements and 4-8 parts of a meat quality regulating agent; the refined traditional Chinese medicine powder comprises raw materials as follows: all-grass of delavay pararuellia, thinleaf milkwort root-bark, vitis flexuosa, cowpea roots, cistanche, medicinal fermented mass, microcos leaves, poria cocos, atractylodes lancea, chicken's gizzard-membrane, fructus amomi, liquorice, almonds, mulberry leaves, areca nuts, fructus aurantii, officinal magnolia bark, peach seeds, fructus cannabis and immature bitter oranges. The Chinese herbal medicine formula has effects of moistening five internal organs, promoting muscles to grow, strengthening muscles and bones, regulating qi, strengthening the spleen and invigorating the stomach, the special meat quality regulating agent can effectively ensure that a large number of cereals are eaten in a fattening period, the deposition of fat among muscle fibers is increased, meanwhile, the pH in the stomach is regulated, acidosis is prevented, the normal growth of microorganisms in the stomach is guaranteed, and purposes of fattening and the improvement on the beef quality are achieved.

The invention discloses a slow-release regulating agent for preventing rumen acidosis and a preparation method thereof, which relate to the field of scientific nutrition of animals. The slow-release regulating agent comprises the following raw material components by gram: 0.3 to 0.5 gram of sodium bicarbonate, 0.15 to 0.17 gram of magnesium oxide, 0.01 to 0.03 gram of nicotinic acid, 0.01 to 0.03 gram of cobaltous sulfate, 0.01 to 0.03 gram of zinc sulfate, 0.01 to 0.03 gram of hydroxypropyl methyl cellulose and 0.3 to 1.5 gram of starch. The preparation method comprises the following preparation steps of: 1. sieving the sodium bicarbonate, the magnesium oxide, the nicotinic acid, the cobaltous sulfate and the zinc sulfate; 2. uniformly mixing the sieved components and an appropriate amount of starch; 3. adding an appropriate amount of absolute ethyl alcohol and stirring for pelletizing; 4. drying and weighing; 5. adding the sodium bicarbonate and mixing uniformly; and 6. calculating tablet weight and tableting. With the invention, the conventional method in which excessive volatile fatty acid produced in a rumen is neutralized by directly filling sodium bicarbonate or adding magnesium oxide is changed. Rumen acidosis is prevented, the treatment effect on rumen acidosis is enhanced, and direct damages to the rumen membranes of ruminants and microbial floras in rumens are reduced.

An anti-hypothermia composition is provided, in particular an anti-hypothermia composition that prevents hypothermia caused by general anesthesia during surgical operations. The composition prevents hypothermia by preventing the decrease in the biological function of patients and correcting acidosis. Specifically, the anti-hypothermia composition is a preparation containing a bicarbonate ion and provided in the form of an infusion fluid. The infusion fluid preferably contains sodium bicarbonate as a major component that serves as a source of the bicarbonate ion, along with each or a combination of other electrolytes, glucose and amino acids.

The present invention relates to one kind of somatostation aqua preparation and its preparation process and application in preparing medicine for preventing and treating serious acute esophagus varicose hemorrhage, acute gastric and duodenal ulcer hemorrhage, acute erosive gastritis, acute hemorrhagic gastritis, etc. The preparation consists of somatostation in 0.1-1000 mg each 0.1-500 ml, medicinal supplementary material, which may be mannitol, polyglycol, cyclodextrin, etc., and water. The preparation process includes compounding, sterilizing, packing, and other steps. The somatostation aqua preparation has high stability, easy preparation and other features, and has wide application foreground in preparing medicine for preventing and treating serious acute esophagus varicose hemorrhage, acute gastric and duodenal ulcer hemorrhage, acute erosive gastritis, acute hemorrhagic gastritis, etc.

The invention relates to biotin natural vegetable and fruit powder, which is prepared from the following raw materials in percentage by weight: biotin 0.3%, natural fruit powder (apple juice powder) 49.7%, and natural dietary fiber 50%. The preparation method of the biotin natural vegetable and fruit powder comprises the following steps: placing biotin, natural fruit powder and natural dietary fiber into a three-dimensional movement mixer (model: SYH-200) in the above compounding ratio, and mixing at room temperature and humidity of 45-60 g / m<3> under a rotation speed of 30-50 rpm for 15-20 min; and subpackaging with compound aluminum-plastic bags (3 g / bag) in a dry and clean environment. The biotin natural vegetable and fruit powder provided by the invention can supplement biotin to patients suffering from biotin deficiency. The proper supplementation of biotin can enhance enzyme activity, and improve ketoacidosis and acidosis.

The invention relates to a low-moisture mixing straw compressed fodder for flocks and herds. The low-moisture mixing straw compressed fodder for flocks and herds is prepared from the following raw materials in parts by weight: 600-750 parts of straws, 100-200 parts of dry bagasse or straws, 50-120 parts of air-dried mulberry branch and leaf powder, 20-40 parts of urea, 10-20 parts of salt, 5-10 parts of sodium bicarbonate, 10-40 parts of molasses, 10-30 parts of mountain flour and 3-5 parts of microbial preparations. Compared with the prior art, the low-moisture mixing straw compressed fodder for flocks and herds provided by the invention has the advantages and positive effects that (1) the storage time is prolonged, namely the water content of the straws is reduced, so that the lactic acidizing time of the straws is prolonged, the straws are prevented from getting mildew and rotten and the storage time is prolonged; (2) the nutritive value and the feed intake are increased: the water content of the straws is reduced from 70% and above to 50% and below, so that the nutritive value and the feed intake can be obviously increased; (3) the transportation cost is reduced: the water content of the straws is reduced and the corresponding nutrient content is increased, so that the transportation cost can be reduced; (4) the happening rate of acidosis and diarrhea of the flocks and herds is reduced. Compared with the high-moisture straws eaten by the flocks and herds, the low-moisture straws eaten by the flocks and herds can obviously reduce the happening rate of acidosis and diarrhea of the flocks and herds.

The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX) in human cells. The successful expression of AOX in human cells and in Drosophila has been shown to confer spectacular cyanide-resistance to mitochondrial substrate oxidation, alleviate oxidative stress, apoptosis susceptibility and metabolic acidosis. AOX is well tolerated when expressed ubiquitously in the whole organism. AOX expression is a valuable tool to limit the deleterious consequences of respiratory chain deficiency.

The invention provides a method for managing experimental animal respiration, which utilizes a clinic anesthesia machine for the anesthetization of the animal experiment, performs tracheal cannula on an animal, adopts an animal temperate maintenance instrument to keep warm, and keeps the body temperature at the physical level (37 plus or minus 0.5 DEG C) all the time during the anesthesia process. The method is used for solving the animal respiration management problem during the traditional anesthesia process, the same inhalation anesthesia concentration and the stable body environment are also maintained during the whole anesthesia process. By the method, not only is the stress response of the experimental animal reduced, but also the vital sign stability of the experimental animal can be maintained during the inhalation anesthesia process of a long time (such as 4 hours), the mortality is low and the reviving can be stable, and the influences of trauma stress, hypoxia-ischemia, hypercapnia, acidosis and other interference factors on the experimental result can be eliminated. The method effectively controls the respiratory tract of the experimental animal, and also maintains the inhalation anesthesia of the volatile anesthetics with constant concentration, which is output to the animal.

Compositions and methods for reducing inflammation and pain associated with acidosis. One embodiment of the composition comprises a plurality of carrier particles, wherein the plurality of carrier particles hold a plurality of alkaline compounds, and wherein the alkaline compounds can be delivered to, and absorbed across, lipid membranes into the blood stream in small quantities over an extended period of time.

The invention relates to drinking water with hydrogen or deuterium, and a preparation method thereof, and belongs to the technology field of drinking water. The drinking water with hydrogen or deuterium is made by adding pure hydrogen or deuterium into pressurized drinking water. The preparation method comprises the steps of reducing the temperature of drinking water in a high pressure vessel to 0 DEG C-5DEG C, and increasing the pressure in the vessel to 1.2-1.5atm; adding the pure hydrogen or deuterium to increase the solubility of the hydrogen or the deuterium to 30mL / L. The drinking water with hydrogen or deuterium can enable a person to ingest protium which is good for human body when the person drinks the drinking water with hydrogen or deuterium, thereby improving the metabolism of the human body, smashing causal active oxygen (free radical) which causes diseases, strengthening nature curability of birth of the human body, activating organs, improving natural immunity of the human body, enabling waste in vivo to quickly discharge, delaying aging and improving acidosis of the human body. The drinking water with hydrogen or deuterium is new concept drinking water, which has definite functions, good taste and suitability for both the old and the young.

The invention relates to a feed additive for improving the energy intake level of beef cattle after delivery, and aims to solve the current problems of abnormal rumen fermentation, low crude fiber digestibility and easy ruminal acidosis when the energy intake level of the beef cattle after delivery is improved by greatly increasing the concentrate feed ratio in a daily ration. The feed additive is prepared from astragalus, pilose asiabell root, licorice, uniflower swisscentaury root, Chinese angelica, leonurus, acorn kernel meal, dried orange peels, mint, dandelion, parslane herb and shizandra berry which are dried, crushed and screened. The feed additive is added into a concentrated feed of the beef cattle after delivery and can be directly fed. The feed additive can improve the crude fiber digestibility while improving the energy intake level, does not influence the rumen fermentation, avoids the happening of the ruminal acidosis, and has the characteristics of convenient operation, high safety, easily available sources, low cost and the like.

A system is provided for a keto-acidosis protocol which includes a computer processor having patient parameter data input. The patient parameter data input to the computer processor may include the patient's blood glucose level, a target patient blood glucose level, a patient's carbon dioxide level, a patient's sodium level, a patient's blood pH value, and the patient's potassium level which has been measured. A patient hydration computer program assesses the patient's hydration state. Coupled to the patient hydration computer program is a patient potassium computer program to assess the patient's potassium level and a patient blood pH value computer program assesses the patient's blood pH value. A display monitor is coupled to the computer processor for displaying indicia thereon responsive to the actuation of the patient hydration computer program, the patient potassium computer program, and the patient blood pH value computer program.

The invention provides an Angus beef finished cattle feeding and management method. The method comprises the following steps that 1, finished cattle are divided into bred cattle and young dairy cattle, the bred cattle refer to 6-18-months-old cattle, and the young dairy cattle refer to 18-months-old cattle to prenatal cattle; 2, the following buffering agent is added into daily ration to serve as an additive; 3, a good feeding and management environment is set up, a pasture is kept clean and sanitary, disinfection is carried out in time, infectious diseases are prevented, treatment needs to be carried out in time during attack, and according to the treatment rules, acidosis is eliminated, electrolyte is supplemented, and the blood volume is expanded. The formula of feed and the feeding and management method are optimized, and finally the morbidity of rumen acidosis is reduced and reduced to be smaller than 15%. The method is applied to feeding, the cattle grow fast, and the weight is increased by 1.2 kg or above.

The invention relates to a food additive that includes, relative to the total weight thereof: about 3.5 wt % of capsicum oleoresin containing 6 wt % of a capsaicine and dihydrocapsaicine mixture; about 5.5 wt % of cinnamaldehyde; about 9.5 wt % of eugenol; the balance up to 100% consisting of hydrogenated vegetable oils. The invention also relates to the uses of said additive for improving the daily distribution of food ingestion by animals, for increasing the amount of water drunk by animals, or for preparing a food product intended for the preventive or therapeutic treatment of animal digestive disorders, such as acidosis or bloating. This food additive is particularly adapted for ruminants such as bovine cattle.

An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.