27 results about "Acidosis" patented technology

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and / or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g., neurosurgery, endovascular clot removal, spinal tap, aneurysm repair, or deep brain stimulation, as well as retinal edema), as well as hyponatremia and excess fluid retention, and diseases such as epilepsy, retinal ischemia and other diseases of the eye associated with abnormalities in intraocular pressure and / or tissue hydration, myocardial ischemia, myocardial ischemia / reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines, as well as to novel assays for identifying aquaporin inhibitors.

Embodiments of the present invention include methods of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TME acidosis, which could provide substantial immunotherapeutic benefits. Here, ex vivo modeling shows that CERs can intentionally elevate pH to an anti-tumor level and that increased alkalinity promotes activation of naïve macrophages. Embodiments of the invention include pairing CER treatment protocols with existing electric field-based cancer therapies or use as a stand-alone therapy.

The invention provides a ruminant rumen health monitoring and conditioning integrated device and an acidosis prevention method, and relates to the technical field of rumen monitoring, the ruminant rumen health monitoring and conditioning integrated device comprises a fixed seat, a fixed cylinder is fixed at the bottom of the fixed seat, an elastic plate is fixed at the bottom of the fixed cylinder, and a movable cylinder is fixed at one end of the bottom of the elastic plate; and a limiting plate is movably mounted on the side of the fixed seat. A rotating seat rotates on a rotating ring, the rotating seat drives a threaded column to move upwards when rotating, the threaded column moves upwards through a positioning pipe and a positioning column, the positioning column moves upwards to drive a supporting disc to move, and the supporting disc moves to push a supporting rod to open towards the side; after the supporting rod is unfolded, the elastic plate circularly expands to form a supporting point from the interior of the animal, the elastic plate is matched with the fixed seat to achieve extrusion sealing installation under different thicknesses, and the movable barrel drives the initial height of the monitoring assembly to be adjusted under the movement of the elastic plate.

The invention provides a traditional Chinese medicine composition for preventing and treating cattle hoof diseases as well as a preparation method and application thereof, and belongs to the technical field of veterinary traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 40 parts of honeysuckle flower, 15 to 20 parts of herba artemisiae scopariae, 20 to 25 parts of radix astragali seu hedysari, 12 to 18 parts of poria cocos, 10 to 15 parts of rhizoma atractylodis macrocephalae, 6 to 12 parts of radix angelicae sinensis, 4 to 8 parts of radix paeoniae rubra, 12 to 18 parts of rhizoma dioscoreae, 9 to 13 parts of fructus cnidii, 8 to 12 parts of radix achyranthis bidentatae and 5 to 10 parts of liquorice root. The traditional Chinese medicine composition is scientific in formula, has the effects of clearing away heat and toxic materials, eliminating dampness and astringing sores, tonifying qi and activating blood, relieving swelling and pain and strengthening tendons and bones through combination of the medicines, can effectively prevent and treat common hoof diseases such as foot rot, cattle laminitis and hoof abscess caused by factors such as acidosis, bacterial infection and downward flow of damp-heat, and has the advantages of remarkable curative effect, no medicine residue, high safety and the like.

The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes dual layer membrane compositions, elements and methods useful with such amperometric analyte sensor systems.

The invention belongs to the field of animal nutrition and feed science, and relates to a feeding technology capable of improving production performance, body health (immunity and oxidation resistance) and economic benefit of mutton sheep and improving rumen pH value, blood buffer capability and blood acid-base balance maintaining capability, namely preventing chronic rumen acidosis, and a daily ration preparation method thereof. According to the feeding technology and the daily ration preparation method, vitamin B12 (cyanocobalamine) is added into the mutton sheep high-concentrate daily ration (the concentrate-to-coarse ratio is 6: 4), the adding level is 0.5 mg / kg in terms of dry matter per kg of the daily ration, it is at least guaranteed that the pre-feeding period is 7 days and the positive test period is 30 days or above in the feeding time of the mutton sheep, the production performance, the organism immunity, the oxidation resistance and the economic benefits of the mutton sheep can be improved, and the mutton sheep feed is suitable for large-scale production. The pH value of the rumen, the blood buffering power and the blood acid-base balance maintaining capacity are improved, namely the effect of preventing chronic acidosis of the rumen is achieved, and the mutton sheep feed additive is suitable for mutton sheep with the weight being 34 kg or above. The method is easy to operate and safe in production, and a new thought and method are provided for preventing chronic rumen acidosis under the condition that mutton sheep are fed with high-concentrate daily ration.

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating transmissible gastroenteritis (TGE) of lactating piglets, which effectively solves the problem that the prior art is only directed to the transmissible gastroenteritis with a low mortality rate of the piglets or sows with a mild disease, is not directed to the TGE with a high mortality rate of the lactating piglets with a severe disease, and cannot rapidly correct the problems of dehydration and acidosis of the lactating piglets, compared with the prior art, the traditional Chinese medicine composition for treating the TGE of the lactating piglets comprises Nansha-Shen, Beisha-Shen, Shihu, Yuzhu, Oyster, and can nourish Yin and produce body fluid, can effectively improve the dehydration and metabolic acidosis of the lactating piglets, and achieve the effects of treating the TGE and reducing the mortality rate, and the reasonable process is adopted to prepare the traditional Chinese medicine composition, so that the traditional Chinese medicine composition is convenient to use.

The invention relates to the technical field of biological medicine, in particular to application of tripterine or medicinal salt thereof in preparation of medicine for treating ketoacidosis or symptoms caused by ketoacidosis. The invention provides application of tripterine or medicinal salt thereof in preparation of a medicine for treating ketoacidosis or symptoms caused by ketoacidosis. The result of the specific embodiment of the invention shows that the tripterine can obviously reduce the mouse serum beta-hydroxybutyric acid level caused by hunger; the tripterine can be used for remarkably reducing the expression of HMGCS2 in the liver of a mouse; the dapagliflozin remarkably promotes the level of beta-hydroxybutyric acid, and the tripterine remarkably reduces the level of mouse serum beta-hydroxybutyric acid caused by treatment of the dapagliflozin. Therefore, tripterine can be used for treating or improving ketoacidosis or symptoms caused by ketoacidosis. The invention provides a new technical scheme for treatment and improvement of ketoacidosis or symptoms caused by ketoacidosis.

The invention provides a composition for preventing or treating acidic urinary stone of pets and application of the composition. The composition comprises citrate, N-acetylglucosamine, a corn stigma extract and a lysimachia christinae hance extract. The citrate can compete with oxalate ions and is preferentially combined with calcium ions to form a soluble calcium citrate compound, so that formation and growth of calcium oxalate crystals are inhibited, and kidney metabolic acidosis caused by improper acidification of urine is prevented. N-acetylglucosamine can repair a glycosaminoglycan layer of a bladder mucosa, reduce crystal adhesion and urethra stimulation, inhibit bacteria from adhering to the urethra, and reduce calculus and infection risks; the corn stigma extract is used for diluting the oxalic acid concentration of urine by increasing the urine volume of pets; the active ingredients of the lysimachia christinae hance extract can relieve urinary tract inflammation and smooth muscle spasm and relieve pain. The composition provided by the invention can effectively reduce formation of acidic urinary stones of pets, prevent bacterial adhesion and recurrent cystitis, and improve urinary system health of pets.

The invention relates to the technical field of pharmaceutical preparations, in particular to a sodium bicarbonate Ringer's injection and a preparation method thereof. According to the invention, sodium bicarbonate is efficiently encapsulated in carboxyl modified PEGylated lipidosome, and is integrated into a standard Ringer electrolyte system, so that a high-stability, precipitate-free and slow-release acid-base regulation function is realized, and the long-standing problems of precipitation and degradation of the sodium bicarbonate Ringer injection are solved; the method is suitable for metabolic acidosis treatment and perioperative period management, and has an important clinical application value and a wide industrialization prospect.

The invention provides a composite freeze-dried brewing grain for maintaining health of urinary systems of pets and preventing auresis and a preparation method of the composite freeze-dried brewing grain, and relates to the field of pet foods. The composite freeze-dried brewing grain for maintaining the health of the urinary system of the pet and preventing the closed urine disease comprises a composite freeze-dried staple food grain and urinary health nutrition powder which are mutually independent. According to the composite freeze-dried brewing grain capable of maintaining the health of the urinary system of the pet and preventing the closed urine disease and the preparation method of the composite freeze-dried brewing grain, disclosed by the invention, the risks of nutrient imbalance, metabolic acidosis and hypokalemia induction in the prior art are effectively avoided, and the composite freeze-dried brewing grain is good in palatability and high in safety; by means of multi-dimensional systematic intervention of physical dilution, chemical regulation, barrier repair and anti-inflammatory relieving, urine crystal precipitation is inhibited, bladder intima is protected, bladder smooth muscle is relaxed, and the purposes of maintaining pet urinary system health and preventing closed urine diseases are achieved fundamentally.

The invention provides a metabolic acidosis risk assessment method and device, electronic equipment and a storage medium. The method comprises the following steps: allocating an initial metabolic acidosis risk level to a target patient based on initial medical data of the target patient, and determining an initial detection item set of the target patient based on the initial metabolic acidosis risk level; wherein the metabolic acidosis risk grade is divided into high risk, medium risk and low risk; dynamically updating the metabolic acidosis risk level of the target patient and the matched detection item set based on the real-time medical data corresponding to the detection item set of the target patient, and dynamically updating the metabolic acidosis risk level of the target patient and the matched detection item set based on the real-time metabolic acidosis risk level of the target patient and the real-time medical data corresponding to the detection item set. And carrying out metabolic acidosis risk early warning. The accuracy and efficiency of metabolic acidosis risk assessment can be improved, and then the medical safety and efficiency are greatly improved.

The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

To provide an ATP production promoter useful for preventing or treating diseases associated with decreased ATP production, particularly renal impairment. [Solution] The present invention comprises an ATP production promoter containing a component having URAT1 inhibitory activity. Preferably, the component having URAT1 inhibitory activity is at least one selected from the group consisting of benzbromarone, probenecid, dotinurad, recinurad, and berinurad. The present invention is expected to be useful as a preventive and therapeutic agent for diseases of decreased ATP production, and is particularly useful as a therapeutic and / or preventive agent for nephrotic syndrome, chronic glomerulonephritis, chronic tubulointerstitial nephritis, chronic pyelonephritis, amyloid kidney, familial juvenile hyperuricemia nephropathy, autosomal dominant tubulointerstitial kidney disease, nephronoplasia, renovascular hypertension, renal vein thrombosis, renal arteriovenous fistula, renal tubular acidosis, Gitelman syndrome, Bartter syndrome, Fanconi syndrome, Lowe syndrome, Alport syndrome, kidney and ureteral stones, and chronic renal failure.

The application provides a method and system for pet acidosis prevention based on acid-base neutralization, relates to the technical field of pet maintenance, acquires target pet information, extracts feeding information, generates a time-feeding sequence, wherein the time-feeding sequence has multiple feeding nodes, extracts diet information to obtain a diet type set, collects pH, obtains multiple food pH sets, obtains a multi-stage risk cluster, inputs the multi-stage risk cluster and pet basic information into a risk prediction model, outputs an acid-base neutralization scheme, and sends the acid-base neutralization scheme to a staff for pet acidosis prevention. The application solves the technical problem that the prior art cannot perform targeted management according to the type and age of a pet, so that the pet acidosis prevention cannot be effectively performed, realizes accurate grasping of pet basic information and maintenance information, and matches corresponding acid-base neutralization schemes for different types and different ages of pets, so that the technical effect of improving the pet acidosis prevention effect is achieved.

The application discloses a kind of kaurane diterpene compounds or its medicinal salt, its chemical structure is as shown in formula (I). The compound is extracted, isolated from the fermentation product of the fungus (Eutypella sp.D-1) of the north polar arched shell genus (Eutypella sp.D-1) with the preservation number CCTCC NO:M 2013144 for the first time.The application further provides the extraction method of the compound, including the steps of liquid fermentation of fungus, extraction obtains total extract, and separation and purification by vacuum column chromatography, reverse phase ODS column chromatography and high performance liquid chromatography. Through zebra fish and mouse in-vivo pharmacological experiment, the compound of the application can significantly improve the abnormal behavior induced by domoic acid (DA), prolong the latent period of poisoning onset, relieve the symptoms of poisoning, and exhibit good neuroprotective activity. Therefore, the compound of the application can be used as a lead compound for preparing a drug for preventing or treating domoic acid poisoning and memory loss injury caused thereby, and provides a scientific basis for developing and utilizing polar marine medicinal resources.

According to the metabolic acidosis-oriented drug administration effect evaluation method and system, localized data source nodes are deployed in a medical institution, patient diagnosis and treatment data are safely stored and processed, data privacy is ensured, a unified federal data model and a semantic interoperability layer are established, and the evaluation efficiency is improved. The consistency of cross-mechanism data in structure and semantics is realized; an access control and auditing mechanism is constructed based on a distributed account book technology, an intelligent contract is used for managing a data strategy, tasks are scheduled, operation logs are recorded, transparency and traceability of data use are guaranteed, a federal privacy protection computing engine adopts a central coordinator to cooperatively work with a local computing agent, and the data security is improved. A deep learning model based on a time sequence is trained through a federal learning mechanism, and the correction ability and long-term prognosis influence of a specific administration scheme on metabolic acidosis are quantitatively evaluated. According to the method, privacy protection is enhanced through anonymization, pseudonymization and security aggregation technologies, multi-mechanism collaborative evaluation is supported, and data utilization and security compliance are considered.

The invention provides a composition containing medicinal and edible astragalus polysaccharide and application of the composition in reducing blood sugar. The composition provided by the invention consists of astragalus polysaccharide, tremella polysaccharide, lycium barbarum polysaccharide and angelica polysaccharide. The mass ratio of the raw materials is (1-3): (1-3): (1-3): (1-3). The hypoglycemic effect of the plant polysaccharide and the composition thereof is proved through a hyperglycemia mouse model, it is shown that the four plant polysaccharides can reduce the blood sugar of mice, after the four plant polysaccharides are compounded, the obvious synergistic interaction effect is shown, and the effect is obviously better than that of other schemes that every two plant polysaccharides are combined or combined in a stacked mode. Clinical medical manifestations of polydipsia, polyphagia, diuresis and weight loss of diabetes mellitus are slowed down and improved after polysaccharide combination treatment, a positive effect on reduction of hyperglycemia is achieved, the adopted plant polysaccharide is safe and non-toxic, blood sugar can be effectively reduced, and the diabetes mellitus health-care product has a good health-care effect on diabetes mellitus. The traditional Chinese medicine composition can also prevent acute complications caused by hyperglycemia, such as diabetic ketoacidosis, hyperglycemia syndrome and the like.

The invention provides a multi-terminal training method of an acidosis identification model, electronic equipment and a storage medium. The method comprises the following steps: receiving a global model sent by a central server node, wherein the global model is divided into a plurality of sub-modules according to the cause type of metabolic acidosis; according to the etiological type at which each secondary client node is skilled, distributing a corresponding sub-module to each secondary client node; distributing the distributed sub-modules to the corresponding secondary client nodes, so that each secondary client node performs local training on the received sub-modules by using the corresponding local dominant pathogenesis data; receiving sub-module parameters which are returned by each secondary client node and are subjected to local training; performing aggregation processing on each received sub-module parameter to obtain a local aggregation model parameter of the first-level client node; and the local aggregation model parameters are fed back to the central server node for updating the global model, so that the problems in the prior art are solved.

This invention discloses a myelin-inspired three-dimensional PEG-modified tetrahedral framework nucleic acid and its application in achieving long circulation and rapid renal clearance. Using a DNA tetrahedral framework as a programmable backbone, PEG units are periodically introduced onto each edge of the DNA tetrahedron. The PEG chains are used as active structural components rather than passive surface modifiers to construct a myelin-inspired three-dimensional topological PEG network coating structure. Without significantly increasing the size of small molecules, a dense steric barrier is formed, significantly reducing serum protein adsorption and nuclease degradation. Simultaneously, it efficiently crosses the glomerular filtration barrier, achieving a synergistic effect in mice with approximately a two-fold increase in blood circulation half-life and over 90% renal clearance within 4 hours. Furthermore, it exhibits good biocompatibility and in vivo safety, providing a novel, efficient, and safe nucleic acid drug delivery strategy for diseases related to the accumulation of target substances, such as hyperbiliary acidosis.

The invention provides a traumatic lethal triple sign multi-modal prediction method and system based on machine learning, and the method comprises the steps: generating multi-modal data based on collected blood coagulation function data, arterial blood pH value, core body temperature data and bleeding amount, and processing the multi-modal data to obtain target fusion information; generating supplementary dose suggestions of fibrinogen by adopting a hierarchical storage strategy; generating target early warning information according to the causal association strength and the supplementary dose suggestion; generating an intervention parameter set according to the real-time bleeding amount, the acidosis degree and the body temperature variation in the target fusion information in combination with the target early warning information; based on the target early warning information and the intervention parameter set, obtaining a multi-modal prediction result of the traumatic and lethal triad sign; according to the application, accurate prediction, real-time risk early warning and personalized intervention recommendation of the traumatic lethal triple symptoms are realized, and the treatment efficiency and the patient survival rate are effectively improved.

The invention provides application of sphingosine 1-phosphate in preparation of a medicine for treating burn compound hemorrhagic shock, and belongs to the technical field of biological medicine. The sphingosine 1-phosphate can enhance the activity of p-AMPK in red blood cells, further activate the activity of BPGM and promote conversion from 1, 3-BPG to 2, 3-BPG, so that the oxygen release capacity of the red blood cells is improved, and the intracellular respiration and mitochondrial functions of all organs are improved. The sphingosine 1-phosphate effectively relieves metabolic acidosis and metabolic disorder caused by burn compound hemorrhagic shock, remarkably improves the energy metabolism state and partial pathological indexes of lung tissue and kidney tissue, and provides a solid scientific basis for treating burn compound hemorrhagic shock by using sphingosine 1-phosphate. The potential of the gene in the aspect of improving clinical prognosis is shown.

The invention discloses a pimarane diterpenoid compound or a pharmaceutical salt thereof. The chemical structure of the pimarane diterpenoid compound is shown as a formula (I). The compound is extracted and separated from a fermentation product of Eutypella sp.D-1 with the preservation number of CCTCC (China Center For Type Culture Collection) NO: M 2013144 for the first time. The invention also provides an extraction method of the compound. The extraction method comprises the following steps: carrying out liquid fermentation on fungi, extracting to obtain a total extract, and carrying out separation and purification through reduced pressure column chromatography, reversed phase ODS column chromatography and high performance liquid chromatography. As proved by in-vivo pharmacological experiments of zebra fish and mice, the compound disclosed by the invention can be used for remarkably improving behavior abnormality induced by domoic acid (DA), prolonging the poisoning attack incubation period and relieving poisoning symptoms, and shows good neuroprotective activity. Therefore, the compound disclosed by the invention can be used as a lead compound and is used for preparing a medicine for preventing or treating domoacidosis and memory deficiency injury caused by domoacidosis, and a scientific basis is provided for developing and utilizing polar marine medicinal resources.

Embodiments can relate to compositions and methods for the treatment of hair loss, which can include treatment of alopecia. The compositions and methods relate to an oral supplement to oral minoxidil includes a SLC22A9 inducer, a HIF-alpha inducer, and / or an acidifying agent. Acidifying blood of a patient suffering from alopecia can cause mild acidosis which can up-regulate SLC22A9 and / or down-regulate AABC3. Inducing SLC22A9, inducing HIF-alpha, and / or acidifying blood of the patient can facilitate oral forms of minoxidil to enter hair follicles.