66 results about "Treatment success" patented technology

The invention is directed to methods of measuring an immune response by comparing sequence-based clonotype frequency data from successively measured clonotype profiles. In particular, the invention includes immunotherapies of cancers, such as lymphomas, that include sensitive pre- and post-vaccination sequence-based measurements of changes in a patient's immune repertoire, thereby providing a sensitive measure of the likelihood of treatment success.

Certain embodiments of the invention provide methods of assessing a patient's risk for atrial fibrillation (AF) recurrence after receiving treatment with an AF treatment modality, that include determining, from left atrium (LA) tissue image data of a patient, a level of a parameter that is positively proportional to an amount of unhealthy tissue in a wall of the LA of the patient; and outputting, to an output device, an indicator of a comparison between (i) the determined level and (ii) a first threshold level of the parameter, the first threshold level derived from LA tissue image data of at least one other patient, who experienced an AF recurrence after treatment with the AF treatment modality. In certain embodiments, levels of the parameter equal to or greater than the first threshold level are indicative of a significant risk of AF recurrence after treatment with the AF treatment modality.

Devices and methods for assisting valve function, replacing venous valves, and predicting valve treatment successes. In at least one embodiment of an endograft valve device of the present disclosure, the device comprises an endograft body configured for expansion from a collapsed configuration to an expanded configuration within a luminal organ and comprising a first portion having a proximal end defining a proximal end aperture and a distal end defining a distal end aperture, the first portion tapering toward the distal end so that the distal end aperture has a relatively smaller cross-sectional area than the proximal end aperture when the valve device is expanded, and a valve portion positioned at or near the distal end of the first portion, the valve portion configured to receive fluid flowing through the distal end aperture of the first portion.

The invention discloses a tooth arranging method in orthodontics. By intelligent quantitative analyses, a reference scheme is provided for an orthodontic process, so that the scheme design process canbecome more convenient and fast, the orthodontic scheme is more accurate, the orthodontic treatment time is reduced, and the treatment success rate is improved.

The invention discloses a differential method for navigation electronic map, a matching method and a device, wherein the matching method comprises steps of: carrying out first matching treatment on afirst navigation electronic map and a second navigation electronic map according to the names of reference substances of the first navigation electronic map and the second navigation electronic map; and using the reference substances with the same names as the reference substances of the first matching treatment success. By using the invention, the map encryption or the difference which is whollyshifted can be effectively solved, thus solving the problem of low difference processing accuracy caused by looking up two version data differences from geometry point of view.

The present invention relates to methods for predicting the outcome of therapeutic intervention in cases of leukemia, especially acute lymphoblastic leukemia in children and adults. The present invention evaluates a gene expression profile and identifies prognostic genes of cancers, in particular leukemia, more particularly B-precursor acute lymphoblastic leukemia (ALL). The present invention provides a method of determining prognosis of leukemia, in particular, acute lymphoblastic leukemia, more particularly B-precursor ALL and predicting therapeutic outcome of a patient. The method comprises the steps of first establishing the threshold value of at least three prognostic genes of leukemia, preferably at least eight prognostic genes, or preferably, as many as 26 prognostic genes. Then, the amount of the prognostic gene(s) from a leukemia patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene(s) which is indicative of therapeutic success or failure, whereby the prognostic outcome of the patient is determined/predicted.

The present invention is related to a method of classifying a sample of a patient who suffers from or being at risk of developing cancer, said method comprising the steps of determining in said sample from said patient, on a non protein basis, the expression level of at least one gene encoding for a hormone receptor selected from the group comprising estrogen receptor, progesterone receptor and/or androgen receptor in said sample; comparing the one or more expression level(s) determined with one or more expression level(s) of one or more reference genes, and classifying the sample of said patient from the outcome of the comparison into one of at least two classifications.

The invention provides an oral soft tissue detection device and an oral soft tissue detection method based on optical Doppler imaging, wherein an optical fiber type Michelson interferometer hardware system built by a frequency sweep laser with a central wavelength of 1310 nm and a phase resolution algorithm software system are adopted to achieve the imaging detection of a biological tissue three-dimensional structure and a microvascular blood flow velocity. The specific implementation process comprises that the backscattered light of an interferometer sample arm and the backscattered light a reference arm generate an interference signal at a coupler; a photoelectric balance detector receives the interference signal; a 12-bit data acquisition card performs data acquisition; a phase resolution algorithm performs information processing; image reconstruction is carried out to obtain a sample structure image and a microvascular blood flow velocity result; and the information is applied to clinical diagnosis and later treatment process detection on oral diseases by a doctor, so that the influence process of oral soft tissue diseases on the three-dimensional structure and the microvascular blood flow rate of the oral soft tissue diseases can be monitored so as to substantially improve the treatment success rate of the oral diseases.

The invention discloses a medical guide system for emergency treatment call information input and intelligent graded diagnosis and treatment. The medical guide system comprises a user terminal, a cloud server, a disease analysis module, a doctor-seeing suggestion module and an emergency treatment triage and guide module, wherein the user terminal is loaded on a user mobile terminal through an APPor a WeChat program, a user registers a login account and can perform operations such as data filling, patient symptom reporting and the like on an operation interface, and the cloud server realizes data transmission among the user terminal, the disease analysis module, the doctor-seeing suggestion module and the emergency treatment triage and guide module through a network. According to the medical guide system with the intelligent grading diagnosis and treatment function, the doctor-seeing time of a patient can be effectively advanced so as to avoid the optimal treatment time from being missed, a treatment scheme can be provided according to patient symptom analysis so as to effectively save medical resources and improve the diagnosis and treatment efficiency and the treatment success rate, and non-emergency patients can be left in primary hospitals for graded diagnosis and treatment so as to meet national medical policies.

A method of identifying one or more biomarkers associated with one or more drugs effective to stop or repress proliferation of cancer cells, and a system for predicting effectiveness of the same. The method includes statistically analyzing (i) a first dataset of expression levels of proteins or glycoproteins in the cancer cells and (ii) a second dataset of responses of the cancer cells to drugs to identify at least one biomarker associated with effective repression of the cancer cells, and correlating or associating at least one protein or glycoprotein biomarker with a response of the cells to at least one of the drugs effective to stop or repress the proliferation of the cancer cells. The protein and/or glycoprotein expression level datasets may be generated experimentally or taken from published information. The method advantageously determines and/or predicts drug sensitivity of various cancer cells using protein and glycoprotein biomarkers.

A system and method for assessing an intravenous catheter site is described in embodiments herein. An application accessible on a mobile device may be used to take calibrated photographs of an intravenous catheter site. The resulting calibrated image may be compared to previously taken calibrated images to determine a complication. Success of treatments to the complication may be tracked and the patient's electronic medical record may be updated.

The invention relates to a model and a system for predicting severe new coronal pneumonia as well as an establishment method and a prediction method of the model and the system, and the prediction model is a progression risk score calculation model obtained according to lung diseases, age, immune globulin M (IgM), CD16 +/CD56 + NK cells and aspartate transaminase (AST) of a patient with new coronal pneumonia so as to predict the risk of progressing from mild/ordinary type to severe new coronal pneumonia. According to the invention, light/ordinary patients with high development risk can be identified, and the diagnosis and treatment success rate of critical patients can be improved.

Methods for biomechanical mapping of the female pelvic floor may include the steps of inserting a vaginal tactile imaging probe into vagina; recording tactile responses for vaginal walls during vaginal wall deformation by moving a probe as well as dynamic pressure patterns during voluntary or involuntary muscle contractions in multiple test procedures; followed by calculating multiple biomechanical parameters characterizing vaginal tissue elasticity, pelvic support structures and dynamic pelvic functions. Individual biomechanical parameters may be visually represented by positioning their value within the established physiological parameter ranges varying from normal to diseased conditions. The methods may be used for identification of pelvic floor tissues with low elasticity, deteriorated or damaged pelvic support muscles and ligaments, and muscles with low contractive capability. Other methods include the steps of collecting clinical history and completing gynecological examinations of the pelvic floor and calculating probabilities of treatment success for pelvic diseases depending on a proposed treatment using a predictive mathematical model.

The invention relates to the technical field of tunnel construction, in particular to a construction method of a subway shield tunnel crossing a prestressed anchor cable. The construction method comprises the following steps that construction preparation is made before a shield machine crosses the anchor cable, and a bin opening point is preset after the preparation is completed; then a jet grouting pile is used for reinforcement in an anchor cable area; a reinforced soil body for rotary jet grouting reinforcement is tested, after reinforcement meets requirements, shield tunneling is carried out, anchor cable crossing construction is carried out, and shield tunneling parameters are controlled and analyzed in the construction process; according to the excavation parameters, the bin openingpoint opening operation is reasonably selected, the anchor cable wound on a cutter head is removed, or a cutter is replaced; and after the bin opening operation is completed, shield tunneling construction is restored, and finally the shield machine crosses the anchor cable. The construction method is simple in process; the jet grouting pile reinforcement technology and the shield bin opening technology are relatively mature, the implementation efficiency is high, and the construction safety is ensured; and the basis and construction experience are provided for the subsequent process that a shield crosses the anchor cable, the anchor cable treatment success rate is improved, and the construction difficulty is reduced.

The invention discloses a cranial periphery position finder which comprises a puncture point constraining plane, a rectangular wire and a puncture wire. A rotary seat and puncture point positioning balls are arranged on the puncture point constraining plane; guide grooves which are perforated through ball centers of the puncture point positioning balls are formed in the puncture point positioning balls; a mounting rod is movably mounted on the rotary seat, a mounting block is movably arranged on the top of the mounting rod, a sliding rod is movably mounted on the mounting block and is perpendicular to the mounting rod, and an end of the sliding rod is connected with one end of a sagittal position reference surface; a rotary cushion surface is arranged at the other end of the sagittal position reference surface, the rotary cushion surface and the sagittal position reference surface are coplanar, and a bearing tube is arranged on the rotary cushion surface; a wide edge of the rectangular wire penetrates the bearing tube, a wire tube is arranged at a long edge of the rectangular wire, and the puncture wire penetrates the wire tube. The cranial periphery position finder has the advantages that the cranial periphery position finder is simple in structure, convenient to operate and high in target hit rate, the patient treatment time can be shortened, accurate puncture can be guaranteed, the treatment success rate can be increased, and popularization and application of the cranial periphery position finder primary hospitals can be facilitated.

The invention discloses a method for synthesizing a nano-targeting gene pRNA-3WJ-siLNAgapmer-aptamer. Firstly, pRNA is packaged with a bacteriophage Phi29 with a 'three-way junction' structural domain3WJ, and pRNA-3WJ is taken as a gene vector; then small interfering LNA is in chimerism in one end of the 3WJ; an RNA aptamer of a CD40 molecule capable of being in targeted combination with a CD40 cell is in chimerism in the other end of the 3WJ to synthesize the nano-targeting gene pRNA-3WJ-siLNAgapmer-aptamer, wherein locked nucleic acid siLNAgapmer corresponds to a tuberculosis gene Mce4, andthe aptamer corresponds to CD40. The nano-targeting gene pRNA-3WJ-siLNAgapmer-aptamer can be targeted into a lesion, effectively inhibit the growth and survival of mycobacterium tuberculosis, and hasa high treatment success rate.

The present invention provides a compound drug for treating diabetes, the compound drug is prepared by berberine intestinal controlled-release microcapsules and a common western medicine for treating diabetes, 10 to 90 percent of the daily maximum dose of the berberine which is the active ingredient in the berberine intestinal controlled-release microcapsules and 90 to 10 percent of the daily maximum dose of the active ingredient of one common western medicine which is chosen randomly for treating diabetes are used for compound preparation. The berberine intestinal controlled-release microcapsules used in the compound drug of the present invention are the effective drug for treating diabetes, and the microcapsule diameter is 35 to 5000 Mum. The present invention provides the compound drug for treating diabetes, which mainly makes use of the complementary synergistic effect of the main drugs to achieve the purpose of reducing the blood glucose. The compound drug of the present invention for treating diabetes has high treatment success rate, less toxicity, fewer side effects and lower dose; furthermore, the present invention can effectively improve the compliance of the medication of the patients, so as to enhance the effect of reducing blood glucose of the drugs treating diabetes.