24 results about "Lateral ventricles" patented technology

The application belongs to the field of neuropharmacology and medicine, and particularly relates to application of taurine cholic acid in preparation of a drug for preventing or treating Alzheimer's disease. Through animal model experiment verification, the A beta lateral ventricle injection is used to prepare an AD mouse model, and after oral administration of TCA for 2 weeks, cognitive behavior and pathological indexes are significantly improved.

The invention relates to a touch fluid neuron specific tracing imaging agent, a preparation method and application, and belongs to the technical field of nuclear medicine imaging, the tracing imaging agent is composed of a nerve tracer agent horseradish peroxidase (HRP), zirconium-89 isotope chelated by deferoxamine and a pharmaceutically acceptable carrier, the effective tracking window of the tracer agent is prolonged to 120 hours, and the effective tracking window of the tracer agent is prolonged to 120 hours. The multi-stage synaptic transfer period of the fluid touching neuron can be completely covered; the spatial resolution is improved by 5-8 times compared with that of traditional FDG-PET, and a fluid touching neuron cluster can be accurately presented; the in-vitro serum stability is excellent, the radiochemical purity is still larger than or equal to 80.5% within 120 hours, PET / MRI bimodal imaging can be adapted, drug administration is conducted through lateral ventricle minimally invasive injection, the probe is suitable for various animal models such as mice, rats and non-human primates, in-vivo dynamic tracing of sympathetic fluid neuron trans-synapses can be achieved on the premise that no tissue damage exists, and the probe has a good application prospect. And a key technical tool is provided for neural circuit analysis, neuroscience basic research and preclinical research of neurodegenerative diseases.

The invention discloses a lateral ventricle drainage device capable of automatically adjusting pressure, which comprises a drainage tube capable of being mounted on a sliding block of a height adjusting frame, the height adjusting frame is existing and is equipped in hospitals, the sliding block is arranged in the middle of the height adjusting frame, scale marks are arranged on two sides of the height adjusting frame, and the sliding block can slide up and down to adjust the height. The pulley mechanism is installed on the sliding block and can generate elastic torsion when rotating, the pulley mechanism has the elastic torsion, the drainage tube bypasses the pulley mechanism from the upper side and then is divided into a right section and a left section, the right section is provided with an elastic expansion bag, and the left section is provided with a transparent dropper which is communicated with outside air and used for observing the dripping speed. The pulley mechanism has a clockwise torsion force to balance the gravity of the expansion bag, the tail end of the left section is connected with a drainage bag, when the drainage amount is increased, the expansion bag expands to drive the pulley mechanism to rotate clockwise, the dropper ascends to raise the position of the liquid outlet so as to reduce the drainage flow speed, and the flow speed adjustment is achieved.

The invention belongs to the technical field of biology, and particularly relates to a construction method of a respiratory syncytial virus infected mouse model. Disodium clodronate liposome with the concentration of 4ng / mL is injected into the lateral ventricle of the mouse through stereotactic positioning of the brain. 48h after injection, mouse brain tissues are taken to detect the activation state of microglial cells through immunofluorescence and WB, after it is confirmed that the microglial cells are inhibited, RSV (virus titer: 2.8 * 10 < 6 > PFU) nasal drop infection experiments are carried out on the mouse, and after the 5th day after virus infection, the mouse is infected by the RSV (virus titer: 2.8 * 10 < 6 > PFU) nasal drop infection experiments. Likewise, mouse brain tissue is taken for virus load detection, and neuropathological changes of the mouse brain tissue are observed through HE staining, immunofluorescence and TUNEL staining, so that the method can be used for constructing a research model of RSV-related nervous system diseases.

The application provides a brain cortex thickness morphological analysis method and system of MR images, and relates to the technical field of medical image data processing.The method comprises the following steps: obtaining a head three-dimensional high-resolution magnetic resonance T1 weighted image sequence of a patient with intractable epilepsy to be evaluated; performing bias field correction and brain tissue stripping on the image sequence to construct an initial brain parenchyma three-dimensional voxel model containing individual lateral ventricle expansion morphological characteristics; based on the initial brain parenchyma three-dimensional voxel model, extracting an initial isosurface of the interface between gray matter and white matter; calculating a local curvature tensor for a deep brain sulcus region in the initial isosurface; performing topological defect repair and mesh smoothing on the initial isosurface according to the local curvature tensor to obtain an individualized cortex surface mesh model eliminating ventricle expansion deformation artifacts.The application realizes accurate registration of image space and surgical physical space.

The present application provides a compound for treating Alzheimer's disease designed based on artificial intelligence, a preparation method and medical uses thereof. The compound is shown as formula I. Through pharmacological experiments, it is found that compounds 548 and 398 both have the effect of inhibiting LPS-induced neuroinflammation, in addition, compound 548 can improve LPS lateral ventricle injection mouse neuroinflammation, improve Aβ 1‑42 Lateral ventricle injection mouse neuroinflammatory injury, so the compound shown as formula I can be used for preparing a drug for treating Alzheimer's disease.

This application provides a method for measuring fetal ventricular ratio and an ultrasound imaging system. The method is applied to an ultrasound imaging system, which includes a processor. The processor acquires an ultrasound image of a cross-section of the fetal lateral ventricle; the processor determines the midline of the brain based on the ultrasound image of the cross-section of the lateral ventricle; the processor acquires a first farthest point on the lateral wall of the lateral ventricle in the ultrasound image that is farthest from the midline of the brain, and acquires the length of a first perpendicular line from the first farthest point to the midline of the brain; the processor acquires a second farthest point on the medial side of the skull in the ultrasound image that is farthest from the midline of the brain, and acquires the length of a second perpendicular line from the second farthest point to the midline of the brain; the processor determines the fetal ventricular ratio based on the lengths of the first and second perpendicular lines. This application improves the efficiency of doctors and increases the accuracy of the obtained ventricular ratio.

The invention discloses a brain puncture trocar for puncture of neonatal hydrocephalus through a fonfonis ventricle under ultrasonic guidance, and relates to the technical field of brain puncture trocar, the brain puncture trocar comprises a connecting seat main body, one end of the connecting seat main body is provided with a long round splicing piece, one side of the long round splicing piece is connected with a connecting hard cannula, and the other side of the long round splicing piece is connected with a connecting sleeve. The brain puncture trocar comprises a hard puncture needle and a connecting hard cannula, a liquid guide soft cannula is installed in the connecting hard cannula, and hydrophobic scale stripes are sprayed to the outer side of the liquid guide soft cannula, and it is ensured that the position of the hard puncture needle can be monitored in real time through an ultrasonic device in the puncture process of the brain puncture trocar; meanwhile, the position of the hard puncture needle is subjected to naked eye tracking through light spots formed by the optical fiber of the hard puncture needle under the skin of a patient, so that the depth and position monitoring mode in the puncture process of the brain puncture trocar is effectively expanded, and it is ensured that medical staff can clearly judge the puncture depth and position of the head of the brain puncture trocar in real time; therefore, the operation convenience and the operation precision of the whole brain puncture trocar are effectively improved.

This invention discloses the application of the FAM26F gene in the diagnosis and treatment of depression, belonging to the interdisciplinary field of molecular biology and neuropsychiatry. This invention reveals for the first time that downregulation of the FAM26F gene expression disrupts glutamate homeostasis by affecting the expression of glutamate transporters and receptors, thereby leading to depressive-like behaviors. Based on this, this invention provides two core applications: first, the application of the FAM26F gene in the preparation of diagnostic products for depression, achieving objective diagnosis by detecting the expression level of this gene in samples such as peripheral blood; second, the application of the FAM26F gene in the preparation of therapeutic drugs for depression, wherein the drug uses a gene therapy vector that upregulates the expression of this gene as its active ingredient, and is administered via lateral ventricle injection or nasal nebulization, effectively reversing depressive-like behaviors in animal models. This invention provides a novel, precise diagnostic target and targeted treatment strategy for depression.

The invention discloses a magnetic resonance imaging method for measuring the volume fraction of periarterial space cerebrospinal fluid with heart rate activity. The method comprises the steps that brain magnetic resonance images are collected, and meanwhile the time sequence of pulse signals is collected; the brain magnetic resonance image corresponds to the pulse signal period, and a plurality of pieces of magnetic resonance image data at equal intervals in the pulse signal period are generated; segmenting a lateral ventricle region in the brain magnetic resonance image, and calculating the CSF average signal intensity of cerebrospinal fluid in the lateral ventricle region; calculating a peak value and a valley value of a magnetic resonance signal time sequence one by one pixel or in an interested area to obtain a signal fluctuation change magnetic resonance signal difference value; dividing the magnetic resonance signal difference value of the signal fluctuation change by the average signal intensity of the lateral ventricle cerebrospinal fluid CSF to obtain the volume fraction caPVS of the periarterial space cerebrospinal fluid. The perivascular space cerebrospinal fluid volume fraction calculated by the method can effectively reflect perivascular space participating in lymphatic-like circulation, and the influence of pathological perivascular space such as expanded perivascular space is eliminated.

The application relates to a kind of brain CT perfusion image full-automatic post-processing methods, comprising: reading CT perfusion image;The CT perfusion image is preprocessed, and the skull perfusion image with skull is obtained, and the brain tissue image containing lateral ventricle after removing skull;Obtain lateral ventricle segmentation result binary graph, comprising: using the skull perfusion image with skull, obtain the optimal image layer of the largest connected domain area in skull;In the brain tissue image, from the optimal image layer, find the first distance towards the direction of skull top, find the second distance towards the direction of skull bottom, obtain the image layer containing lateral ventricle;The image layer containing lateral ventricle is converted into feature image, and lateral ventricle segmentation is carried out on each layer feature image, and lateral ventricle segmentation result binary graph is obtained;Using the brain tissue image, arterial input function and perfusion parameter map are sequentially obtained;The perfusion parameter map is binarized, and the lesion area is obtained in combination with the lateral ventricle segmentation result binary graph.

The application belongs to the field of image segmentation, and relates to a lateral ventricle choroid plexus segmentation and quantification method based on enhanced T1 weighted magnetic resonance images, S1: obtaining brain enhanced T1 weighted magnetic resonance images and performing pretreatment to obtain standardized brain images; S2: based on the standardized brain images, combining a preset enhancement intensity threshold and a lateral ventricle anatomical position constraint, constructing a choroid plexus candidate region; S3: using a trained choroid plexus segmentation model to perform feature discrimination and segmentation on the choroid plexus candidate region to generate an initial segmentation mask; S4: performing post-processing optimization on the initial segmentation mask to remove false positive regions to obtain a final lateral ventricle choroid plexus segmentation mask; and S5: based on the final lateral ventricle choroid plexus segmentation mask, performing choroid plexus quantification parameter calculation. The problems of low segmentation precision, poor integrity and insufficient stability are solved.

The present invention discloses a teaching model and demonstration method for dynamically demonstrating the cerebrospinal fluid circulation pathway, relating to the field of demonstration models. The model comprises a brain shell having cavities including the lateral ventricles, the third ventricle, and the fourth ventricle, and the subarachnoid space; aqueducts are provided between the cavities and between the fourth cavity and the subarachnoid space; the interior of each cavity is connected to a water tank via a water inlet pipe and a water pump, and the water tank contains water simulating cerebrospinal fluid; a plurality of water outlets are provided on the subarachnoid space, and the water outlets are connected to the water tank via a drain pipe; elastic filler serving as brain tissue is provided between all cavities and between the cavity and the subarachnoid space; the outlet of each aqueduct is configured as a variable diameter section, and a float is placed in the aqueduct; a motor is provided outside each aqueduct, and the output shaft of the motor passes through the aqueduct and is connected to the float via a traction rope. The present invention enhances teaching effectiveness by dynamically simulating the normal circulation process of cerebrospinal fluid and the pathological and physiological changes after obstruction.

The invention discloses a neurological serious high-simulation invasive operation simulation training and neuroanatomy demonstration teaching system, and belongs to the technical field of medical education and clinical skill training. The system comprises a neuroanatomy demonstration system, a high-simulation invasive operation simulation training system and an integrated computer host. The dissection demonstration system visually displays key structures such as cerebral artery, vein, cranial nerve and cerebrospinal fluid circulation through a dynamic model and a three-dimensional visualization technology; the operation simulation training system adopts a biomimetic material human body model to truly simulate the hand feeling and feedback of more than ten neurological serious invasive operations such as lateral ventricle puncture, trachea cannula and central venous catheterization; the computer host integrates the functions of case scene simulation, process video recording and redisk and intelligent examination and evaluation. According to the invention, integration, scenario and intelligence of anatomy teaching and operation training are realized, a safe, repeatable and evaluable high-quality training environment is provided for students, and the efficiency and clinical practice ability of neurological intensive medicine teaching are effectively improved.

The present application belongs to the field of brain image processing, and particularly relates to a lateral ventricle widening prediction method, device, program product and medium, the steps of the method comprising: performing three-dimensional segmentation processing on a magnetic resonance image through a three-dimensional multi-sequence segmentation model to obtain a three-dimensional segmentation result; the three-dimensional multi-sequence segmentation model is constructed based on a three-dimensional nnUNet network, and a topological loss function is used to train the three-dimensional multi-sequence segmentation model; inputting the three-dimensional segmentation result into a prediction model to obtain a classification result of lateral ventricle adverse prognosis. The present application uses an nnUNet network to perform three-dimensional full-automatic segmentation of the lateral ventricle, and a topological loss (TopoLoss) is used in the segmentation process, and then a classification result of lateral ventricle adverse prognosis is obtained, which improves the continuity and accuracy of three-dimensional segmentation, and solves the problem that traditional two-dimensional segmentation cannot capture the overall anatomical morphology of the lateral ventricle.

The invention belongs to the field of brain image processing, and particularly relates to a lateral ventricle widening prediction method and device, a program product and a medium, and the method comprises the steps: carrying out the three-dimensional segmentation of a magnetic resonance image through a three-dimensional multi-sequence segmentation model, and obtaining a three-dimensional segmentation result; the three-dimensional multi-sequence segmentation model is constructed based on a three-dimensional nnUNet network, and a topology loss function is adopted to train the three-dimensional multi-sequence segmentation model; and inputting the three-dimensional segmentation result into a prediction model to obtain a classification result of lateral ventricle malfunction prognosis. According to the method, three-dimensional full-automatic segmentation of the lateral ventricle is carried out by adopting the nnUNet network, TopoLoss is adopted in the segmentation process, then a classification result of poor prognosis of the lateral ventricle is obtained, the continuity and accuracy of three-dimensional segmentation are improved, and the problem that the overall anatomical form of the lateral ventricle cannot be captured through traditional two-dimensional segmentation is solved.

The application discloses a gene medicine for treating deafness-dystonia-optic neuropathy syndrome caused by TIMM8A gene defect and application. The medicine core is a modularly designed adeno-associated virus vector system which carries an expression cassette containing a tissue-specific promoter and a human TIMM8A treatment gene. The application realizes precise treatment through local minimally invasive injection according to different symptoms: AAV-Anc80L65-MYO15-TIMM8A is injected into the cochlea to treat sensorineural hearing loss; AAV2 / 4-Brn3b-TIMM8A is injected into the vitreous body of the eyeball to treat optic neuropathy; AAV9-hSyn-TIMM8A is injected into the central lateral ventricle to treat dystonia. Preclinical studies have confirmed that the strategy can efficiently express TIMM8A protein in the corresponding target cells, significantly repair hearing, visual and motor function defects, and correct mitochondrial dysfunction from the pathological mechanism.

The embodiment of the invention discloses a personalized lateral ventricle image generation and disease risk assessment method and device, and the method comprises the steps: obtaining an original historical image, an original current image and a plurality of original clinical features of a patient, carrying out the standardization processing, and carrying out the three-dimensional volume reconstruction of the standardized historical image and the standardized current image, obtaining a reconstructed historical image and a reconstructed current image; performing lateral ventricle segmentation and feature extraction on the reconstructed historical image and the reconstructed current image by using a neural network model; performing image registration and alignment on the reconstructed historical image and the reconstructed current image based on the feature positioning key points to obtain an aligned historical image and current image, and extracting difference features based on the historical image and the current image; and inputting the difference features and the standardized clinical features into a trained random forest model, and obtaining patient disease types, corresponding disease probabilities and risk levels based on overall disease probability analysis, which are output by the random forest model.

Embodiments disclose systems and apparatus that provide neurogenesis activation by FUS stimulation including activating quiescent NSCs in the subventricular zone of the lateral ventricles and promoting the proliferation of NSCs and subsequent differentiation into newly regenerated neurons. Also disclosed is a conventional MRI guided tFUS system programmed for use with ultrasonic activation of NSCs. A wireless electronic driving configuration for transcranial use under MRI guidance is provided and a cylindrically distributed ultrasound transducer array design to provide increased steering range in at least two axes. A close integration of tFUS with MRI navigation, achieved by a novel wearable thin-film MRI coil array tightly integrated with the transducer array, enables full navigation performance of MRI in real time during FUS treatment.

The invention belongs to the field of nerve injury repair, and particularly discloses application of FGA-sourced 12 peptide in preparation of nerve injury repair drugs, active polypeptide disclosed by the invention is sourced from human endogenous polypeptide FGA and consists of 12 amino acids, and related functions of the active polypeptide are not reported at present. The effect of the micromolecule active polypeptide in nerve injury repair is studied, and it is found that the cell culture fluid containing the micromolecule active polypeptide can be used for promoting survival of hippocampal neuronal cells after oxygen-glucose deprivation; in a rat hypoxic ischemic brain injury model, it is found that the small molecule polypeptide can enter neuronal cells through lateral ventricle administration injection, and encephaledema caused by hypoxic ischemia is remarkably reduced; the cerebral infarction area of the hypoxic ischemic brain injury of the rats is improved; the survival of neurons in the cortex area and the hippocampus area is promoted Therefore, the FGA-sourced 12 peptide disclosed by the invention has a good prospect in preparation of reagents or medicines for repairing nerve injury.

The invention discloses a ventricular puncture positioning sterile film based on an external auditory canal-inner canthus coordinate system, and relates to the technical field of medical instruments, the ventricular puncture positioning sterile film comprises a sterile film body, and sliding grooves are formed in the positions, close to the edges of the two sides, of the outer surface of the sterile film body. According to the ventricular puncture positioning sterile pasting film based on the external auditory canal-inner canthus coordinate system, when a patient is subjected to lateral ventricular puncture positioning, a medical worker enables the two clamps on the surfaces of the two arch-shaped sliding rails to be accurately aligned with the external auditory canals on the two sides of the patient to form an external auditory canal datum plane system, the external auditory canal datum plane system stretches across the external auditory canals on the two sides to form an immovable bony datum, and then the external auditory canal-inner canthus coordinate system is obtained by referring to scale marks; the angle of the magnetic attraction puncture guide cylinder is adjusted to point to the inner canthus of a patient, the neodymium iron boron magnetic ring arranged in the magnetic attraction puncture guide cylinder can generate 0.5 N attraction force to attract an external puncture needle and prevent deviation, it is ensured that a needle head is attached to the inner wall of the guide cylinder in a gapless mode, the needle is slowly inserted in the guide cylinder direction, and the needle inserting depth is controlled according to surgical specifications; the practicability of the ventricular puncture positioning sterile film based on the external auditory canal-inner canthus coordinate system is improved.

The invention provides a cerebrospinal fluid drainage device and a cerebrospinal fluid drainage method. The device comprises a drainage unit provided with a drainage tube, a moving unit, a monitoring module and a control unit, the monitoring module comprises a distance measuring unit and a flow sensor unit, the distance measuring unit is configured to monitor the drainage height, and the flow sensor unit is configured to sense the flow rate of liquid in the drainage tube; the drainage height is the vertical distance between the drainage tube and the horizontal plane of the anterior corner of the lateral ventricle of the patient; the control unit is in communication connection with the monitoring module and is configured to receive the drainage height monitored by the monitoring module and the liquid flow rate in the drainage tube and send a driving instruction to the moving unit according to the drainage height and a height threshold value and the relation between the liquid flow rate in the drainage tube and a liquid flow rate threshold value; the moving end of the moving unit is connected with the drainage tube, and the moving unit is electrically connected with the control unit and drives the drainage tube to move according to a driving instruction sent by the control unit. The drainage device improves the safety of cerebrospinal fluid drainage.

The application discloses application of sh-SLK in preparation of a preparation for relieving cerebral ischemia-reperfusion injury, and relates to the technical field of gene targeting drugs. An effective active component of the preparation comprises short hairpin RNA sh-SLK capable of targeting and specifically silencing STE20-like kinase gene expression. The preparation is loaded in a recombinant virus carrier, and is formulated into a lateral cerebral ventricle injection dosage form; the preparation is delivered to brain tissues through a brain stereotactic technique, so that high-efficiency expression of sh-SLK is established in ischemic brain tissues, and then the activity of SLK is specifically inhibited.