10 results about "Lateral ventricles" patented technology

The application belongs to the field of neuropharmacology and medicine, and particularly relates to application of taurine cholic acid in preparation of a drug for preventing or treating Alzheimer's disease. Through animal model experiment verification, the A beta lateral ventricle injection is used to prepare an AD mouse model, and after oral administration of TCA for 2 weeks, cognitive behavior and pathological indexes are significantly improved.

The invention belongs to the technical field of biology, and particularly relates to a construction method of a respiratory syncytial virus infected mouse model. Disodium clodronate liposome with the concentration of 4ng / mL is injected into the lateral ventricle of the mouse through stereotactic positioning of the brain. 48h after injection, mouse brain tissues are taken to detect the activation state of microglial cells through immunofluorescence and WB, after it is confirmed that the microglial cells are inhibited, RSV (virus titer: 2.8 * 10 < 6 > PFU) nasal drop infection experiments are carried out on the mouse, and after the 5th day after virus infection, the mouse is infected by the RSV (virus titer: 2.8 * 10 < 6 > PFU) nasal drop infection experiments. Likewise, mouse brain tissue is taken for virus load detection, and neuropathological changes of the mouse brain tissue are observed through HE staining, immunofluorescence and TUNEL staining, so that the method can be used for constructing a research model of RSV-related nervous system diseases.

The present application provides a compound for treating Alzheimer's disease designed based on artificial intelligence, a preparation method and medical uses thereof. The compound is shown as formula I. Through pharmacological experiments, it is found that compounds 548 and 398 both have the effect of inhibiting LPS-induced neuroinflammation, in addition, compound 548 can improve LPS lateral ventricle injection mouse neuroinflammation, improve Aβ 1‑42 Lateral ventricle injection mouse neuroinflammatory injury, so the compound shown as formula I can be used for preparing a drug for treating Alzheimer's disease.

This invention discloses the application of the FAM26F gene in the diagnosis and treatment of depression, belonging to the interdisciplinary field of molecular biology and neuropsychiatry. This invention reveals for the first time that downregulation of the FAM26F gene expression disrupts glutamate homeostasis by affecting the expression of glutamate transporters and receptors, thereby leading to depressive-like behaviors. Based on this, this invention provides two core applications: first, the application of the FAM26F gene in the preparation of diagnostic products for depression, achieving objective diagnosis by detecting the expression level of this gene in samples such as peripheral blood; second, the application of the FAM26F gene in the preparation of therapeutic drugs for depression, wherein the drug uses a gene therapy vector that upregulates the expression of this gene as its active ingredient, and is administered via lateral ventricle injection or nasal nebulization, effectively reversing depressive-like behaviors in animal models. This invention provides a novel, precise diagnostic target and targeted treatment strategy for depression.

The application belongs to the field of image segmentation, and relates to a lateral ventricle choroid plexus segmentation and quantification method based on enhanced T1 weighted magnetic resonance images, S1: obtaining brain enhanced T1 weighted magnetic resonance images and performing pretreatment to obtain standardized brain images; S2: based on the standardized brain images, combining a preset enhancement intensity threshold and a lateral ventricle anatomical position constraint, constructing a choroid plexus candidate region; S3: using a trained choroid plexus segmentation model to perform feature discrimination and segmentation on the choroid plexus candidate region to generate an initial segmentation mask; S4: performing post-processing optimization on the initial segmentation mask to remove false positive regions to obtain a final lateral ventricle choroid plexus segmentation mask; and S5: based on the final lateral ventricle choroid plexus segmentation mask, performing choroid plexus quantification parameter calculation. The problems of low segmentation precision, poor integrity and insufficient stability are solved.

The invention discloses a neurological serious high-simulation invasive operation simulation training and neuroanatomy demonstration teaching system, and belongs to the technical field of medical education and clinical skill training. The system comprises a neuroanatomy demonstration system, a high-simulation invasive operation simulation training system and an integrated computer host. The dissection demonstration system visually displays key structures such as cerebral artery, vein, cranial nerve and cerebrospinal fluid circulation through a dynamic model and a three-dimensional visualization technology; the operation simulation training system adopts a biomimetic material human body model to truly simulate the hand feeling and feedback of more than ten neurological serious invasive operations such as lateral ventricle puncture, trachea cannula and central venous catheterization; the computer host integrates the functions of case scene simulation, process video recording and redisk and intelligent examination and evaluation. According to the invention, integration, scenario and intelligence of anatomy teaching and operation training are realized, a safe, repeatable and evaluable high-quality training environment is provided for students, and the efficiency and clinical practice ability of neurological intensive medicine teaching are effectively improved.

The application discloses a gene medicine for treating deafness-dystonia-optic neuropathy syndrome caused by TIMM8A gene defect and application. The medicine core is a modularly designed adeno-associated virus vector system which carries an expression cassette containing a tissue-specific promoter and a human TIMM8A treatment gene. The application realizes precise treatment through local minimally invasive injection according to different symptoms: AAV-Anc80L65-MYO15-TIMM8A is injected into the cochlea to treat sensorineural hearing loss; AAV2 / 4-Brn3b-TIMM8A is injected into the vitreous body of the eyeball to treat optic neuropathy; AAV9-hSyn-TIMM8A is injected into the central lateral ventricle to treat dystonia. Preclinical studies have confirmed that the strategy can efficiently express TIMM8A protein in the corresponding target cells, significantly repair hearing, visual and motor function defects, and correct mitochondrial dysfunction from the pathological mechanism.

Embodiments disclose systems and apparatus that provide neurogenesis activation by FUS stimulation including activating quiescent NSCs in the subventricular zone of the lateral ventricles and promoting the proliferation of NSCs and subsequent differentiation into newly regenerated neurons. Also disclosed is a conventional MRI guided tFUS system programmed for use with ultrasonic activation of NSCs. A wireless electronic driving configuration for transcranial use under MRI guidance is provided and a cylindrically distributed ultrasound transducer array design to provide increased steering range in at least two axes. A close integration of tFUS with MRI navigation, achieved by a novel wearable thin-film MRI coil array tightly integrated with the transducer array, enables full navigation performance of MRI in real time during FUS treatment.

The invention discloses a ventricular puncture positioning sterile film based on an external auditory canal-inner canthus coordinate system, and relates to the technical field of medical instruments, the ventricular puncture positioning sterile film comprises a sterile film body, and sliding grooves are formed in the positions, close to the edges of the two sides, of the outer surface of the sterile film body. According to the ventricular puncture positioning sterile pasting film based on the external auditory canal-inner canthus coordinate system, when a patient is subjected to lateral ventricular puncture positioning, a medical worker enables the two clamps on the surfaces of the two arch-shaped sliding rails to be accurately aligned with the external auditory canals on the two sides of the patient to form an external auditory canal datum plane system, the external auditory canal datum plane system stretches across the external auditory canals on the two sides to form an immovable bony datum, and then the external auditory canal-inner canthus coordinate system is obtained by referring to scale marks; the angle of the magnetic attraction puncture guide cylinder is adjusted to point to the inner canthus of a patient, the neodymium iron boron magnetic ring arranged in the magnetic attraction puncture guide cylinder can generate 0.5 N attraction force to attract an external puncture needle and prevent deviation, it is ensured that a needle head is attached to the inner wall of the guide cylinder in a gapless mode, the needle is slowly inserted in the guide cylinder direction, and the needle inserting depth is controlled according to surgical specifications; the practicability of the ventricular puncture positioning sterile film based on the external auditory canal-inner canthus coordinate system is improved.

The application discloses application of sh-SLK in preparation of a preparation for relieving cerebral ischemia-reperfusion injury, and relates to the technical field of gene targeting drugs. An effective active component of the preparation comprises short hairpin RNA sh-SLK capable of targeting and specifically silencing STE20-like kinase gene expression. The preparation is loaded in a recombinant virus carrier, and is formulated into a lateral cerebral ventricle injection dosage form; the preparation is delivered to brain tissues through a brain stereotactic technique, so that high-efficiency expression of sh-SLK is established in ischemic brain tissues, and then the activity of SLK is specifically inhibited.