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Use of bilobalide B in preparing medicine for promoting nerve cell regenerate

A technology of nerve cells and ginkgolides, applied in drug combinations, nervous system diseases, pharmaceutical formulations, etc., to achieve the effect of promoting functional improvement and promoting function

Inactive Publication Date: 2009-04-01
北京鑫利恒医药科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it is more difficult to see from the disclosed content that ginkgolide B can promote the proliferation of neural stem cells in different parts of the brain tissue after brain injury

Method used

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  • Use of bilobalide B in preparing medicine for promoting nerve cell regenerate
  • Use of bilobalide B in preparing medicine for promoting nerve cell regenerate

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] [Experimental example 1] Improvement effect of ginkgolide B and ginkgo extract on rat middle cerebral artery occlusion-reperfusion brain injury

[0023] 1. Materials and methods

[0024] 1.1 Experimental animals: male Wistar rats, weighing 280-320 grams, provided by the Institute for the Control of Pharmaceutical and Biological Products of the Ministry of Health. Animals were free to eat and drink, and acclimated to the environment in a clean animal room for one week before the experiment.

[0025] Sample: Provided by the Research Institute of Beijing Xinliheng Pharmaceutical Technology Development Co., Ltd.

[0026] 1.2 Reagent preparation and administration:

[0027] Ginkgolide B, a white powdery solid, is formulated with distilled water, administered by intragastric administration at 1, 4, 10 mg / kg (5 ml / kg body weight) every day for 5 consecutive days.

[0028] The MCAO model group and the sham operation group were intragastrically administered distilled water (5...

experiment example 2

[0048] [Experimental Example 2] Effects of Ginkgolide B on Neurogenesis in Rats

[0049] (1) Preparation of middle cerebral artery ischemia-reperfusion model in rats by line detection method

[0050] 1. Experimental animals

[0051] SD rats, male, weighing 280-300g. Provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: SCXK (Beijing) 2002-2003.

[0052] 2. Experimental reagents and drug preparation

[0053] For ginkgolide (EGB), add 1ml DMSO dropwise to every 100mg ginkgolide to fully dissolve the powder, then add the DMSO solution dropwise to 100ml distilled water, the final concentration of the drug is 1mg / ml (wherein the DMSO content is less than or equal to 1%).

[0054] 3. Grouping of experimental animals

[0055] Adult male SD rats with an initial body weight of 280-300 g were randomly divided into 4 groups. Due to the high mortality rate of animals in this test, 20 animals in each group were initially tested to ensure that t...

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Abstract

The invention relates to the application of ginkgolide B in the preparation of drugs promoting the regeneration of nerve cell, wherein, the nerve cell is the nerve cell at the positions of brain tissue hippocampus, striaturn and lateral ventricle. The ginkgolide B can penetrate the blood-brain barrier to promote the neural stem cells at the positions of cerebral cortex, the hippocampus and the like to proliferate and be transformed into neuron, thus increasing the number of regenerative cells, so as to achieve the goal of rehabilitating neural damnification and preventing and remedying the disease of cerebral stroke.

Description

technical field [0001] The invention relates to the application of ginkgolide B in the preparation of drugs for promoting nerve cell regeneration. Specifically, the present invention relates to the application of ginkgolide B to promote the regeneration of nerve cells in damaged brain tissue hippocampus, striatum, and lateral ventricle. Nerve cell regeneration in hippocampus, striatum, and lateral ventricle damage of brain tissue caused by cerebral ischemia and stroke. Background technique [0002] For a long time, because the paralysis caused by nervous system damage, such as nerve damage caused by stroke and other cerebral ischemic diseases, is often helpless clinically, the traditional view generally believes that the central nervous system (CNS) lacks self-repair after injury. Ability. This traditional view has been challenged since Reynolds and Weiss isolated and cultured stem cells in the adult brain and demonstrated that they can differentiate into the three main typ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P25/00
Inventor 赵文杰颜炜群李平亚张均田
Owner 北京鑫利恒医药科技发展有限公司
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