35 results about "Nerve structure" patented technology

The invention relates to the technical field of medical monitoring and early warning, and discloses a postoperative care risk early warning system for neurosurgical patients. According to the system, real-time monitoring flows of electroencephalogram, intracranial pressure and body surface myoelectricity of a patient are continuously received, and a dynamic interaction network of neuroelectrophysiology and intracranial mechanical states is constructed so as to represent the coupling relation among electroencephalogram rhythm, pressure conduction and postoperative skull windowing area tissue compliance. The system analyzes three types of core parameters of cerebral cortex excitability, cerebrospinal fluid circulation load and cranial cavity compensation space from the network, further calculates a brain tissue perfusion risk and a neural structure compression risk, and generates a corresponding nursing early warning signal and a physiological regulation path. According to the scheme, deep coupling and mechanism risk early warning of multiple physiological signals are achieved, and the postoperative complication risk can be recognized earlier and more accurately.

The invention relates to the technical field of medical image recognition, in particular to an ultrasound-guided nerve block liquid medicine diffusion image recognition method, which comprises the following steps of: dynamically analyzing a set with external expansion morphological feature points on a liquid medicine diffusion boundary to construct directional data representing a diffusion trend, and performing density statistics on the directional data to obtain an image recognition result; therefore, the dominant direction of liquid medicine diffusion in space is accurately identified, judgment is carried out in combination with the change trend of the dominant direction in a continuous time frame, a time slice with the stable and continuous direction is screened out, then the method goes deep into a liquid medicine coverage area, the consistency between the pixel gray scale gradient change and the nerve fiber anatomy trend is compared, and the accuracy of the nerve fiber anatomy is improved. Finally, effective classification of the diffusion paths is realized, an effective diffusion area conforming to the trend of the neural structure and a non-dominant diffusion area towards other tissues can be clearly distinguished, and the accuracy and clinical reference value of an identification result are greatly improved.

The invention provides a nerve regulation and control system and method for a spinal cord ventral epidural region, and the system employs a microprocessor to generate multiple paths of pulse width modulation signals, and drives a voltage-controlled current source after amplitude adjustment. Stimulation current with adjustable frequency, pulse width and amplitude is output to act on a spinal cord ventral nerve structure. Real-time monitoring of stimulation current of each channel is realized through combination of voltage sampling and a single-pole multi-throw analog switch, feedback information of a body position, myoelectricity, pressure and other multi-mode sensors is fused, a closed-loop control mechanism is constructed, and dynamic adjustment and individualized optimization of electrical stimulation parameters are realized. The system has the advantages of being more accurate in electrical stimulation positioning, more sensitive in response, more intelligent in control and the like, and is suitable for intelligent rehabilitation intervention in scenes of spinal cord injury, cerebral palsy, neurological dysfunction and the like.

The invention relates to a differentiated'inner core and outer sheath 'triboelectric stimulation bionic nerve graft and a preparation method thereof. The nerve graft is composed of an outer sheath layer and an inner core layer. Wherein an outer sheath layer is a calcium ion cross-linked waterborne polyurethane / sodium alginate double-network structure hollow conduit, and an inner core layer is oriented conductive polymer / silk fibroin nanofibers. The nerve graft provided by the invention is provided with the sheath part with an internal and external differential gradient hole structure and the bionic inner core similar to a natural nerve structure, when the nerve graft is implanted into a body, the inner core and the outer sheath show differential degradation speeds and hydrophilic-hydrophobic properties, and can generate electrical stimulation synchronously responding to physiological activities, so that regeneration after nerve injury is facilitated.

The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.

A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and / or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and / or reverse the growth of a prostate gland or a prostate tumor.

A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and / or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and / or reverse the growth of a prostate gland or a prostate tumor.

The invention discloses a system for predicting the risk of nerve injury caused by radiotherapy based on deep learning, and belongs to the technical field of medical artificial intelligence and radiotherapy, and the system comprises a neural structure automatic segmentation module, a dose-neural response modeling module, an individualized risk assessment module, a radiotherapy plan optimization module and a closed-loop feedback regulation unit. The system adopts an encoder-decoder deep network to perform high-precision segmentation on nervous tissues, establishes a dose-nerve response quantitative model by fusing dosiomics and radiomics characteristics, and realizes individualized risk assessment based on a multi-factor risk quantitative network. An optimization scheme for balancing tumor control and neuroprotection is generated through Pareto optimal search, collaborative optimization of all the modules is achieved through closed-loop feedback, and decision support is provided for precise radiotherapy.

Systems and methods that deliver a continuous partial nerve conduction block are described. A waveform generator can configure one or more direct current (DC) waveforms to provide a continuous partial nerve conduction block. One or more electrodes can deliver the one or more DC waveforms to provide the partial block to the neural structure. Feedback can be provided to the waveform generator related to the partial block. The feedback includes monitoring a property associated with the partial block and altering a parameter associated with the one or more direct current waveforms in response to the property associated with the partial block.

The invention discloses a spine minimally invasive intervertebral fusion cage and a rigid fixing device thereof, and relates to the technical field of medical implantable instruments, and the spine minimally invasive intervertebral fusion cage comprises a lumbar vertebra body and a vertebral plate nail. According to the spine minimally-invasive intervertebral fusion cage and the rigid fixing device thereof, the total length of the connecting rods is adjusted according to the specific spine curvature of a patient and the actual positions of the two vertebral plate nails, so that the optimal matching position is found and corresponds to the actual requirement, and the spine minimally-invasive intervertebral fusion cage and the rigid fixing device thereof are convenient to use. The stress concentration on a single component is reduced through a surface contact and multi-point multi-direction fixing mode; the rigid supporting frame is symmetrically distributed on the two sides and is not fixed to the middle of the spine, then a core nerve structure is avoided, the symmetrically-distributed rigid fixing devices and the spine jointly form a three-dimensional triangular supporting frame, then lateral bending and rotation are resisted, and therefore the stable supporting structure is constructed; and a good mechanical environment is created for spinal fusion.

The application provides a three-dimensional CT image reconstruction method and system for lumbar disease diagnosis, and belongs to the technical field of three-dimensional medical image reconstruction; a plurality of two-dimensional CT images are acquired to train a deep neural network; a two-dimensional CT image to be segmented is input into the trained deep neural network for segmentation, and the segmented image is used as a pre-reconstruction image; three-dimensional CT image reconstruction is performed on the pre-reconstruction image based on a VTK rendering method, so that the visualization of the three-dimensional CT image is realized. The application can accurately and efficiently simultaneously segment the vertebrae, intervertebral discs and nerve structures in the lumbar CT image, and realizes image visualization through three-dimensional reconstruction of the segmented CT image, thereby providing strong support for lumbar disease diagnosis, preoperative planning and intraoperative guidance.

Systems and methods that deliver a continuous partial nerve conduction block are described. A waveform generator can configure one or more direct current (DC) waveforms to provide a continuous partial nerve conduction block. One or more electrodes can deliver the one or more DC waveforms to provide the partial block to the neural structure. Feedback can be provided to the waveform generator related to the partial block. The feedback includes monitoring a property associated with the partial block and altering a parameter associated with the one or more direct current waveforms in response to the property associated with the partial block.

In an illustrative embodiment, methods and system for increasing coagulation potential and / or triggering a higher platelet activation rate in a subject via auricular neurostimulation include contacting skin of the subject with one or more therapeutic electrodes, each electrode positioned in a respective region of nerve structures of the auriculotemporal nerve (ATN), nerve structures connected to the ATN, nerve structures of the auricular branch of the vagus nerve (ABVN), or nerve structures connected to the ABVN, applying, to the electrodes, one or more stimulation patterns.

1. The name of the design product: stereotactic apparatus (JS302). 2. The use of the design product: using the three-dimensional coordinate system defined by the marks on the skull or other reference points to determine the location of certain subcortical neural structures in order to stimulate, destroy, inject drugs, guide potential, etc. under non-direct exposure. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: stereogram 1.

A surgical access system comprising a tissue dilation assembly and a tissue retraction assembly, both of which may be equipped with one or more electrodes for use in detecting the existence of (and optionally the distance and / or direction to) neural structures.

The invention relates to the technical field of medical images, in particular to a nerve anesthesia puncture auxiliary positioning method based on an ultrasonic image, which comprises the following steps: acquiring a real-time ultrasonic image of a target area; carrying out automatic identification and segmentation on a neural structure in the ultrasonic image; fusing the probe space pose data acquired by the electromagnetic positioning system with the three-dimensional coordinates of the puncture needle; projecting a neural structure position and a virtual needle insertion path guide line on augmented reality display equipment in real time; compared with the prior art which depends on manual visual inspection of an ultrasonic image to position a neural structure and has the defects of high subjectivity, high requirement on operator experience and low minor nerve tract recognition rate, the scheme adopts a deep learning model based on an improved U-Net + + architecture; millimeter-level accurate recognition and segmentation of a neural structure are achieved in combination with a multi-modal fusion enhancement technology, the definition and stability of neural development under complex anatomical conditions are remarkably improved, and a reliable anatomical basis is provided for puncture path planning.

The invention provides pedicle screw implanting equipment based on bioelectrical impedance guidance. The pedicle screw implanting equipment comprises a handle, a sleeve, a connecting rod and a probe, the sleeves are detachably connected with one another; a probe is also arranged in the handle and the sleeve; the lower end of the probe is also sleeved with a connecting rod; the connecting rod is detachably connected with a vertebral pedicle screw; the lower end of the probe extends out of the lower end of the pedicle screw; an electrical impedance acquisition system is arranged in the handle, and the electrical impedance acquisition system is electrically connected with the probe. Implantation of the pedicle screw can be achieved, the bioelectrical impedance value of the tip tissue of the screw can be collected in the implanting process, impedance information of the tip of the screw is collected in real time to sense the tissue layer and the position where the screw is located currently, important tissue and nerve structures are prevented from being damaged, and the accuracy and safety of screw implantation are guaranteed; according to the invention, the tissue information of the tip can be converted into the electrical impedance value, and the type of the tip tissue is output according to the electrical impedance value.

The present disclosure relates to non-invasive nerve identification using snapshot polarimetry. The present disclosure further relates to a system for nerve identification, the system comprising a camera including a sensor, and a filter having a linear polarizer array, an illumination system configured to illuminate a target area with polarized light illumination, the polarized light illumination having at least one predetermined polarization angle, the illumination system including one more light sources, and one or more polarizer filters, and a processor configured to process imaging data obtained from the camera, and output a birefringence map of the target area including indicia of a nerve structure.

The present application provides a nerve regulation system and method for the ventral epidural region of the spinal cord, wherein the nerve regulation system for the ventral epidural region of the spinal cord generates a multi-channel pulse width modulation signal by using a microprocessor, drives a voltage-controlled current source after amplitude adjustment, and outputs a stimulation current with adjustable frequency, pulse width and amplitude to act on the ventral nerve structure of the spinal cord. Real-time monitoring of the stimulation current of each channel is realized by combining voltage sampling and single-pole multi-throw analog switches, while the feedback information of multiple modal sensors such as body position, electromyography and pressure is integrated to construct a closed-loop control mechanism, realize dynamic adjustment and individual optimization of the electric stimulation parameters. The precise activation ability of motor and autonomic nerve function is enhanced, and the present application has the advantages of more accurate electric stimulation positioning, more sensitive reaction, more intelligent control and the like, and is suitable for intelligent rehabilitation intervention in scenes such as spinal cord injury, cerebral palsy, and nerve dysfunction.

In illustrative embodiments, methods and systems for increasing blood coagulation potential in a subject and / or triggering a higher platelet activation rate in the subject via ear nerve stimulation include contacting the subject's skin with one or more therapeutic electrodes, each electrode is positioned in a respective region of a neural structure of an ear temporal nerve (ATN), a neural structure connected to the ATN, a neural structure of an ear branch (ABVN) of a vagus nerve, or a neural structure connected to the ABVN; one or more stimulation patterns are applied to the electrode.

A lateral retractor system for forming a pathway to a patient's intervertebral disc space includes a single dilator and a retractable dual-tapered-blade assembly. The dilator may feature a narrow rectangular body for insertion at an insertion orientation parallel to the fibers of the patient's psoas muscle, at an approximate 45-degree angle to the patient's spine. The retractable dual-tapered-blade assembly consists of only two blade subassemblies, each having a blade bordered by adjustable wings, along with built-in lighting and video capabilities. The dual-tapered-blade assembly may be passed over the single dilator at the insertion orientation and rotated approximately 45-50 degrees to a final rotated orientation parallel to the intervertebral disc space before the two blade subassemblies are retracted away from one another to create the surgical pathway, while simultaneously and continuously assessing for encroachment upon one or more nerve structures within 360-degrees of the instrument. Other embodiments are also disclosed.

This disclosure provides a method for selecting parameters for stimulation of the thalamus using a deep brain stimulator to treat a motor disorder in a subject, such as paralysis of the upper limb and face muscles. Also provided are methods for treating motor disorder in a subject. Also provided is an implantable electrode lead for neuromodulation and recording, configured to provide targeted stimulation and / or recording to multiple anatomically distinct neural structures, specifically the thalamus, the motor cortex, and optionally, the corona radiata, using a single continuous elongate lead body.

Described herein are robotically coordinated systems and methods for safe and efficient spinal decompression and bone milling. In various embodiments, a robotic spinal surgery system is provided with at least three robotic arms co-located on a single mobile base wherein the movement of the robotic arms is coordinated by a central control unit on the base. The system further comprises tools for spinal decompression, elements for protection of nervous tissue and navigation cameras. The nerve protection elements are placed between bony anatomy structures and nervous structures to prevent contact of the spinal decompression tools with the nervous structures. The nerve protection elements further include safety components that can optionally close electrical circuits with the decompression tools and sense or stimulate the nervous structures. Methods of deploying the inventive system in surgery are also provided.

A lateral retractor system for forming a pathway to a patient's intervertebral disc space includes a single dilator and a retractable dual-tapered-blade assembly. The dilator may feature a narrow rectangular body for insertion at an insertion orientation parallel to the fibers of the patient's psoas muscle, at an approximate 45-degree angle to the patient's spine. The retractable dual-tapered-blade assembly consists of only two blade subassemblies, each having a blade bordered by adjustable wings, along with built-in lighting and video capabilities.The dual-tapered-blade assembly may be passed over the single dilator at the insertion orientation and rotated approximately 45-50 degrees to a final rotated orientation parallel to the intervertebral disc space before the two blade subassemblies are retracted away from one another to create the surgical pathway, while simultaneously and continuously assessing for encroachment upon one or more nerve structures within 360-degrees of the instrument. Other embodiments are also disclosed.

The invention relates to the technical field of intelligent monitoring, and particularly provides a neural function and intracranial environment integrated intelligent monitoring method and system.The method comprises the steps that intracranial blood vessel blood flow data, electroencephalogram data and retina nerve fiber layer thickness data are collected in real time and preprocessed; obtaining an ICP estimated value, a TCD pulsation index, EEG spectrum power and an optic nerve OCT thickness mean value; and performing correlation analysis and trend fusion on the ICP estimated value, the TCD pulsation index, the EEG spectrum power and the optic nerve OCT thickness mean value so as to realize integrated intelligent monitoring of the neural function and the intracranial environment. According to the method, correlation analysis can be carried out on the four types of key characteristic values, physiological internal correlation among intracranial pressure, hemodynamics, electroencephalogram physiology and optic nerve structures is mined, and the problem that key correlation information among indexes is prone to being missed in traditional manual analysis can be avoided; and meanwhile, through trend fusion, comprehensive research and judgment of a multi-index dynamic change trend are realized.

The utility model provides a novel retractor device applied to a subclavian approach endoscopic thyroid surgery, and particularly relates to the technical field of medical instruments. The novel retractor device applied to the subclavian approach endoscopic thyroid surgery comprises a handheld device, the two ends of the handheld device are fixedly connected with an upper retractor and a lower retractor respectively, the upper retractor comprises a horizontal end and a vertical end, the horizontal end and the vertical end are cylindrical, the bottom end of the lower retractor comprises a transverse end and a vertical end, and the transverse end and the vertical end are connected with the handheld device. And the transverse end and the vertical end are flat rectangles. The thyroid resection device has the advantages that the thyroid resection device can be used for single-side thyroid resection and double-side thyroid total resection, and the core of the thyroid resection device is unique structural design and operation mechanism. By means of innovative angle adjustment and traction functions, exposure of the thyroid superior pole and surrounding important nerve structures is remarkably improved, and the problems of insufficient exposure, high bleeding risk and nerve injury in the prior art are solved.

The application discloses a method and system for identification of blood vessels, lymph nodes and nerves in surgery, and relates to the technical field of computers, which comprises the following steps: S1, acquiring a surgery video, marking and establishing a blood vessel sample database, a lymph sample database and a nerve sample database; S2, constructing an initial identification model; S3, training the initial identification model to obtain a blood vessel identification model, a lymph identification model and a nerve identification model; S4, collecting the surgery video, and identifying and outlining the contours of blood vessels, lymph and nerves; and S5, visually displaying the surgery video and the contours to a surgeon; the system comprises a collection module, a central processing unit and a display module; the blood vessels, lymph and nerve structures under the laparoscopic surgery visual field are identified in real time by using an artificial intelligence computer model, and the visual display function is combined, so that the surgeon is provided with guidance for resection and avoidance of corresponding blood vessels, lymph nodes and nerves, the surgeon is guided to reasonably identify and resect blood vessels and lymph nodes, the blood vessels and lymph nodes that do not need to be resected are avoided, and the surgery is smoothly assisted.

Described herein are robotically coordinated systems and methods for safe and efficient spinal decompression and bone milling. In various embodiments, a robotic spinal surgery system is provided with at least three robotic arms co-located on a single mobile base wherein the movement of the robotic arms is coordinated by a central control unit on the base. The system further comprises tools for spinal decompression, elements for protection of nervous tissue and navigation cameras. The nerve protection elements are placed between bony anatomy structures and nervous structures to prevent contact of the spinal decompression tools with the nervous structures. The nerve protection elements further include safety components that can optionally close electrical circuits with the decompression tools and sense or stimulate the nervous structures. Methods of deploying the inventive system in surgery are also provided.

A system can locate a neural structure, such as a superficial nerve having a sensory fiber (also referred to as a "target nerve"). The system can include at least an electrical stimulation device, and optionally a recording device that works with the electrical stimulation device to localize the target nerve. The electrical stimulation device can utilize transcutaneous, non-invasive electrical mapping such that one or more electrodes can be positioned on a subject's skin to apply stimulations with electrical signals. The recording device can detect a location of the target nerve based on recordings of the stimulations. The patient can also indicate a location of the target nerve based on sensations elicited by the stimulations. The system can also include a therapy emitting element that can be positioned relative to the electrical stimulation device and deliver light and / or temperature change therapy to the target nerve upon localization.

The application discloses application of SKP-SC-EVs in preparation of DPN treatment drugs and belongs to the technical field of biological medicine.The SKP-SC-EVs in the application can be internalized by SCs, and can directly repair and protect damaged SCs in multiple dimensions, laying a good cell foundation for nerve regeneration, in contrast to other source EVs.In addition, through treatment of DPN model rats with the SKP-SC-EVs, it is proved that the SKP-SC-EVs can effectively improve the nerve sensory and motor functions of the DPN rats, promote the regeneration of the nerve structure and myelin sheath of the rats, enhance the nerve internal microcirculation blood flow, delay the atrophy and degenerative changes of the target muscle, and realize systematic repair of the three functional units of "nerve-vascular-muscle".The DPN treatment scheme provided by the application effectively overcomes the defects in the prior treatment schemes, i.e., single repair effect dimension and difficulty in realizing fundamental reconstruction of nerve functions and keeping long-term stability.