978 results about "Neuromodulation" patented technology

The patent application describes an adaptable neuromodulation device for transcranial electrical brain stimulation. The system can generate complex poly-modulated waveforms by combining multiple pulse parameters in a randomized manner across dimensions like amplitude, frequency, phase, timing, and polarity. It leverages both digital and analog modulation techniques for waveform versatility. The device features pathway optimization algorithms that tune stimulation using neural feedback data to target specific brain region shapes with greater precision. It also enables closed-loop operation for responsiveness to physiological changes. The application details the mathematical and computational foundations, spanning graph theory to generate digital twins. It highlights applications from cognitive enhancement to seizure control. Overall, the innovation promises versatility and precision in non-invasive neuromodulation through adaptable, optimized waveforms grounded in sophisticated modeling.

A system for administering transcranial neuromodulation (TNM) treatment with a medical device capable of delivering a TNM treatment to a patient including an electronic computing device has a processor, computer-readable memory, and a power supply, in communication with the TNM device. A patient interface is in communication with the electronic computing device and the TNM device. The electronic computing device is configured to: receive an initial TNM treatment protocol; communicate same to the TNM device to enable initial TNM treatment; receive patient input through the patient interface; receive an updated TNM treatment protocol based on patient input; and communicate updated TNM treatment protocol to the TNM device to enable updated TNM treatment of the patient.

Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and / or indirect application of thermal and / or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the peroneal, femoral, saphenous and / or tibial nerves. The stimulation may include burst stimulation, and involve receiving an input relating to autonomic nervous system activity of the patient.

A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and / or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and / or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.

The invention provides a closed-loop nerve regulation method and device, a medium and a program product, and relates to the technical field of nerve regulation. The method comprises the steps that an electroencephalogram collection module collects electroencephalogram signals in real time and provides real-time feedback data for nerve regulation and control; the magnetic resonance imaging module provides high-precision brain structure and function positioning information; the three different stimulation modules (transcranial alternating current stimulation, low-field magnetic field stimulation and transcranial magnetic stimulation) can stimulate brain regions with different depths and ranges; the multi-mode navigation module carries out accurate positioning based on the magnetic resonance image; the electroencephalogram detection module analyzes the collected signals; and the central control module coordinates the work of each module. According to the multi-module cooperative working mode, accurate stimulation of different areas and different depths of the brain is achieved, meanwhile, the stimulation effect is ensured through real-time monitoring, and therefore the accuracy and effectiveness of nerve regulation and control are improved.

A neuromodulation system is provided herein. The system can include a cuff electrode, an electronics package, which can be part of a neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.

A neuromodulation system is provided herein. The system can include a cuff electrode, an electronics package, which can be part of a neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

Embodiments of the present disclosure may include a neuromodulation system. The neuromodulation system can include an implantable pulse generator configured to provide neuromodulation to a patient based on a sequence of neuromodulation programs. The implantable pulse generator can include alternately accessible memories. The alternately accessible memories can enable the implantable pulse generator to store a second neuromodulation program while providing neuromodulation according to a first neuromodulation program. The IPG can then transition from providing stimulation according to the first neuromodulation program to providing stimulation according to the second neuromodulation program without stopping stimulation. The neuromodulation system can include a parameter memory. Stimulation parameter updates can be written to the parameter memory. The value of the parameter memory can be used to determine the next stimulation pulse. The IPG can accordingly support pulse-to-pulse changes in stimulation parameters.

A neuromodulation system including at least one input module for inputting a planned neuromodulation event or a series of neuromodulation events and at least one analyzing module for analyzing a neuromodulation event or a series of neuromodulation events.The analyzing module and the input module may be connected such that the input module is configured to forward the planned neuromodulation event or a series of neuromodulation events to the analyzing module and the analyzing module is configured to analyze the planned neuromodulation event or a series of neuromodulation events regarding one or more possible neuromodulation conflict(s).

In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the peroneal, femoral, saphenous and / or tibial nerves. The stimulation may include burst stimulation, and involve receiving an input relating to autonomic nervous system activity of the patient.

A method for treating nerves in a nasal cavity starts with identifying a patient having a condition occurring outside the nasal cavity. The method then involves activating a console attached to a radiofrequency stylus, advancing a distal tip of the radiofrequency stylus into a nostril of the patient, contacting nasal mucosa lining the nasal cavity with a treatment surface of the distal tip, and delivering radiofrequency energy from one set of bipolar electrodes on the treatment surface of the distal tip to a second set of bipolar electrodes on the treatment surface, to treat at least one nerve underlying the nasal mucosa. Treating the nerve (or nerves) involves modulating activity of the nerve to ameliorate the condition occurring outside the nasal cavity.

A closed-loop neuromodulation system, including an electrode array that is implantable to a brain of a subject, analog front-end device (AFD) for selectively selecting and reading a plurality of channels from electrode array, a finite impulse response (FIR) filter for selectively filtering signals from the AFD, a feature extraction engine (FEE) operatively connected to the FIR filter, configured to selectively extract features from signals provided by the FIR filter, a tree-structured hierarchical neural network classifier for detecting disease symptoms, and a multi-channel stimulator having high-voltage (HV) drivers operatively connectable to the electrode array.

Obstructive sleep apnea from blockage of the upper airway can result in significant health issues. Described herein is an intelligent personalized closed loop neuromodulation system and methods to prevent backwards movement of the genioglossus muscle through stimulation of certain branches of the hypoglossal nerve and muscle motor points, by using muscle feedback from electromyogram sensors to provide optimal stimulus. Alternative embodiments to treat neuropathic pain and urinary dysfunction are enclosed.

Disclosed is a neuromodulation device for controllably delivering neural stimuli. The device comprises: a stimulus source configured to provide neural stimuli to be delivered via one or more stimulus electrodes of an electrode array to a neural pathway of a patient in order to evoke a neural response from the neural pathway; measurement circuitry configured to capture signal windows from signals sensed on the neural pathway via one or more measurement electrodes of the electrode array subsequent to respective neural stimuli; and a control unit. The control unit is configured to: control the stimulus source to provide a neural stimulus according to a stimulus intensity parameter; measure an intensity of an evoked neural response in a captured signal window subsequent to the neural stimulus; determine, using a Kalman filter, a feedback variable and an estimate of a posture of the patient from the measured intensity of the evoked neural response, the stimulus intensity parameter, and a target value; and adjust, using a feedback controller, the stimulus intensity parameter so as to maintain the feedback variable at or near the target value.

According to the precise diagnosis and treatment integrated platform and method based on the coupling model, the cavitation effect is predicted through numerical simulation, negative feedback adjustment is conducted on microbubble mediated ultrasonic treatment, and precise control over the microbubble mediated ultrasonic treatment is achieved. Acoustic parameters are adjusted in real time, it can be ensured that treatment focuses on a lesion area, damage to surrounding healthy tissue is reduced, and therefore the accuracy and safety of treatment are improved. The platform integrates cavitation detection and an acoustic feedback mechanism, the microbubble cavitation effect can be monitored in real time, and treatment parameters can be automatically adjusted. Negative feedback closed-loop control can ensure a stable cavitation state, tissue damage caused by excessive cavitation is effectively avoided, and the stability and reliability of treatment are improved. The platform simplifies the operation process of controlling acoustic parameters. A doctor can complete the whole process from treatment to monitoring on the same operation interface through the integrated platform, and convenience and efficiency of clinical operation are improved. The platform is not only suitable for tumor treatment, ablation and drug delivery, but also can be applied to multiple treatment fields such as vascular diseases and neuromodulation, and has wide clinical application prospects and market potential.

Methods and apparatuses are described for modulating multiple integrated neural networks to alter composite sensory processes, such as audition or hearing. These methods and apparatuses may be used for therapeutic and non-therapeutic uses, including enhancing entertainment and communication, by providing a cranio-cervical tuning apparatus worn in or around the outer ear or auricle. These methods and apparatuses may include functional neurosensory bias for neurosensory scrambling neuromodulation to influence composite or multi-modal sensory processes.

The invention provides an artificial intelligence spinal nerve regulation and control system and method based on a multi-modal physiology-nerve-experience closed loop, and relates to the technical field of medical instruments, the system comprises an implantable stimulation and sensing subsystem, a body surface and wearable sensing subsystem, a communication and time synchronization subsystem and a control processing unit, the implantable stimulation and sensing subsystem, the body surface / wearable sensing subsystem and the control processing unit are in communication connection in pairs through the communication and time synchronization subsystem. According to the method, the fundamental limitation that in the prior art, only dosage is maintained, and brain and subjective experience is ignored is broken through, and more stable, more efficient and more personalized accurate pain management is realized through multi-modal fusion and hierarchical cooperative control.

Systems and methods for applying therapeutic ultrasound to the brain to compensate for attenuation and dephasing of ultrasound by each individual's head. The compensation is based on relative ultrasound through-transmit measurements, which are performed using a set of ultrasonic emitters over one side of the head and a set of receivers on the other side. The measurements are performed with the head absent and present. Based on the difference between these measurements, the set of ultrasound waves is adjusted to compensate for attenuations and dephasing caused by the ultrasound wave passing into the head through the scalp and skull. The adjusted set of ultrasound waves provides intended, deterministic ultrasound intensity at the target location. The deterministic delivery enables safe and effective ultrasonic neuromodulation, local drug release from nanoparticle carriers, and microbubble-based disruption of blood-brain barrier for the delivery of drugs, genes, and stem cells across the blood-brain barrier.

In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the saphenous and / or posterior tibial nerves. The therapy may be adjusted based on leg restlessness or movement.

Methods, devices, and systems are described for closed-loop neuromodulation for control of a physiological state. The system includes an energy application system, a user device, a sensor, and a controller. The controller may be configured to select a state phase based on an engagement component. The controller may be configured to prompt at least one of the user device to present a cue to the subject or the energy application system to apply the electrical stimulation to the subject based on the selected state phase. The controller may be configured to measure the set of physiological reactions induced by the selected state phase. The controller may determine a subject bio-psychiatric therapeutic trajectory based on the measured set of physiological reactions from the subject, the subject bio-psychiatric therapeutic trajectory generated by mapping the set of physiological reactions from the subject to the state phase.

The invention relates to the technical field of neuromodulation and rehabilitation treatment, and discloses an intelligent magnetic field neuromodulation rehabilitation system, which comprises a signal acquisition and feature extraction module for acquiring brain signals of a patient and extracting multi-scale variables including microscopic neuron membrane potential, mesoscopic brain region synchronism and macroscopic cognitive state; the magnetic field adjusting module is used for generating and outputting magnetic field stimulation signals according to the optimization result, and the magnetic field stimulation signals comprise frequency, intensity and waveform parameters of a magnetic field; the dynamic optimization module is used for calculating an optimal path of the magnetic field stimulation signal based on the input multi-scale variable and the constraint condition; and the closed-loop feedback control module is used for receiving the real-time brain signal to update the system state and adjusting the parameters of the magnetic field stimulation signal based on feedback. Through multi-scale modeling, real-time feedback regulation and control and man-machine interaction technologies, precise regulation and control, efficient adaptability and visual clinical operation effects of the nervous system are achieved.

An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.

The invention belongs to the field of big data, and provides a wearable nerve regulation and control method and system based on cloud AI control, and the method comprises the steps: collecting user data through a wearable nerve regulation and control device worn on the limb part of a user, the user data being physiological data and / or motion data; uploading the user data to a cloud server, wherein the cloud server is provided with an artificial intelligence model; the artificial intelligence model receives the user data, and generates personalized nerve electrical stimulation parameters in combination with pre-stored user historical treatment data and / or medical history data; the cloud server issues the personalized nerve electrical stimulation parameters to the wearable nerve regulation and control device, and the wearable nerve regulation and control device executes transcutaneous nerve electrical stimulation operation based on the personalized nerve electrical stimulation parameters.

The invention provides a non-invasive nerve regulation and control device. The non-invasive nerve regulation and control device comprises an optical fiber, an optical fiber fixing device arranged at one end of the optical fiber, a laser light source arranged at the other end of the optical fiber and a photoelectric conversion material positioning and injecting assembly. The photoelectric conversion material positioning and injecting assembly is used for injecting a photoelectric conversion material into a specified solution injection point; the photoelectric conversion material is powdery and comprises nanoparticles capable of converting near-infrared light into electric signals, and the photoelectric conversion material is dispersed in normal saline so as to be injected into biological tissues; the laser light source irradiates laser in a near-infrared band to an area where a photoelectric conversion material injection point is located, so that the laser is converted into an electric signal through the photoelectric conversion material, and the electric signal stimulates an area where a solution injection point is located. The non-invasive nerve regulation and control device has the advantages of non-invasiveness, high efficiency, system uniqueness, stability and programmable control, can realize accurate regulation and control of neurons and neural circuits, and has a wide application prospect.

The invention discloses a group brain research equipment synchronization method and device, equipment and a storage medium. According to the group brain research equipment synchronization method, through an accurate timestamp insertion and synchronization mechanism, accurate synchronization, including time synchronization and command and data receiving synchronization, between a plurality of slave machines and the master equipment can be realized, and time alignment of the data is ensured. The invention relates to a nerve regulation technology.

Systems and methods for safety assessment before and during a transcranial ultrasound (TUS) procedure are described. A neuronavigation system is used to determine the probe's position and orientation. The probe's location and the subject's head MRI data are used to simulate the acoustic field within the subject's head. The acoustic field is overlaid on the MRI data and displayed to a clinician for evaluation. The phases of the transmit voltages are adjusted to optimize the location of the peak of the acoustic field to match the targets in the subject's brain. Before and during TUS, the spatial distribution of tissue temperature, MI, TIC, and ISPTA are computed and displayed to the clinician. Acoustic field changes due to the subject's movement are detected, and the TUS operation is terminated if the stimulated acoustic field becomes off-target. Monitoring circuits shut down the neuromodulation if parameters are out-of-range.

Systems and methods for reliably returning a neuromodulation system to a predetermined position relative to a user's head is disclosed. The system includes a neuromodulation device and a stimulation control computing environment. The stimulation control computing environment can be configured with data processing functions to focus ultrasound emission to a target brain region. The system identifies an initial position of one or more ultrasound-emitting elements with respect to the head of a user, uses brain images to identify the target brain region, and performs acoustic simulations to focus ultrasound emissions from the initial position to the target brain region. The distance between an inner surface of the device and a user's head can be measured, and one or more spacing elements can be placed on the inner surfaces based on the measured distances, which enables the reliable return of the neuromodulation device to the initial position with minimal displacement.

Anatomically accurate rodent brain models and phantoms, processes for constructing an anatomically correct computer simulation model of a rodent head, and fabricating the accurate rodent brain models and phantoms, and methods for leveraging the accurate rodent brain models and phantoms production are disclosed, and which may be used for simulated and experimental verification of induced electric fields and for experimentally testing neuromodulation and neuroimaging procedures.