111 results about "Neuromodulation" patented technology

Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and / or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Systems and methods for reliably returning a neuromodulation system to a predetermined position relative to a user's head is disclosed. The system includes a neuromodulation device and a stimulation control computing environment. The stimulation control computing environment can be configured with data processing functions to focus ultrasound emission to a target brain region. The system identifies an initial position of one or more ultrasound-emitting elements with respect to the head of a user, uses brain images to identify the target brain region, and performs acoustic simulations to focus ultrasound emissions from the initial position to the target brain region. The distance between an inner surface of the device and a user's head can be measured, and one or more spacing elements can be placed on the inner surfaces based on the measured distances, which enables the reliable return of the neuromodulation device to the initial position with minimal displacement.

The present application relates to the technical field of neuromodulation, and discloses a neuromodulation system and method for dual-task gated taVNS. The present application collects kinematic data and cognitive performance data of a patient performing a motor-cognitive dual task; obtains an objective maximum load paradigm according to the kinematic data and the cognitive performance data, obtains a subjective maximum load paradigm according to a subjective work load score, and combines the two to obtain a maximum intensity dual-task load paradigm; applies multiple trial dual-task training to the patient under the maximum intensity dual-task load paradigm, and in each trial, determines in real time whether to trigger transcutaneous auricular vagus nerve stimulation according to a dual-dimension gating condition, triggers to generate a stimulation signal when the cognitive correctness condition and the motor safety condition are both satisfied, and suspends the presentation of a new task during the stimulation duration. The present application realizes precise coupling of dual-task training and neuromodulation in the time dimension, and improves the timing specificity and individualization of neuromodulation.

This invention provides an acoustically transparent skull based on the transfer matrix method. The skull includes a matching layer, a coupling layer, and a biomimetic skull. The biomimetic skull matrix has acoustic windows and a stepped groove design for easy and quick assembly, disassembly, and repositioning. The matching layer module is made of epoxy resin-nano-alumina composite material, and its thickness is designed according to a quarter wavelength of the target frequency band. This effectively optimizes acoustic impedance matching and reduces energy loss, becoming a key breakthrough in improving the transmission efficiency of transcranial ultrasound and expanding its application in non-invasive medical fields. This invention focuses on the field of biomechanics and medicine, addressing the problem of low transmission efficiency in transcranial ultrasound technology caused by differences in acoustic impedance of the skull. It can be used to compare the sound transmission effects of single or multiple matching layers at different frequencies. In the future, ultrasound can be more widely used for diagnosis, treatment, neuromodulation, and health / mental status monitoring of astronauts.

Systems, methods, and devices disclosed herein include a transcutaneous spinal cord stimulation (tSCS) system with a stimulation electrode grid. The stimulation electrode grid includes a plurality of anodes and a plurality of cathodes, and the stimulation electrode grid is operable for placement proximate to a spinous process. The system also includes a particularized electrical field generated by selective activation of the stimulation electrode grid. Moreover, a localized tSCS, provided by the particularized electrical field is operable to cause a neuromodulation effect. Also, the stimulation electrode grid includes a substrate material. The plurality of cathodes and the plurality of anodes are both arranged as rows or columns on the substrate material to form an integrated unit. The stimulation electrode grid includes a plurality of selectively activated electrode array activation configurations, and the neuromodulation effect generated by the system can be used to enhance voluntary extremity function and pain management.

This invention relates to a method for suppressing artifacts in neurally modulated stimuli and reconstructing effective features of a brain-computer interface. The method involves simultaneously acquiring multi-channel neural electrical signals and stimulus event information; establishing a preset time window centered on the event moment; extracting transient evidence features, saturation evidence features, and recovery evidence features that occur synchronously with the stimulus from the neural electrical signals; arbitrating the credibility of the stimulus event based on the event information and evidence features to obtain the event arbitration type; generating a corrected event moment when a time offset is detected to form a credible event table; determining the artifact suppression mode and its application window according to the event arbitration type, whereby the artifact suppression mode includes strong suppression, weak suppression, or bypass processing, and performing artifact suppression or bypass processing on the corresponding neural electrical signals; extracting effective features of the brain-computer interface after suppression; and reconstructing features for the feature gaps caused by suppression according to the event arbitration type, outputting the reconstructed features and credibility markers.

A method of controlling a neural stimulus, the neural stimulus being defined by at least one stimulus intensity parameter. The method comprises, generating a stimulus intensity parameter to control a stimulator that generates a stimulus current for application to a tissue, measuring a response of the tissue, evoked by the stimulus current, determining a response parameter indicative of the measured response, in response to the response parameter being less than a first threshold, setting the stimulus intensity parameter to a desired stimulus intensity level; and in response to the response parameter being greater than a second threshold, adjust the stimulus intensity parameter according to a feedback variable derived from the measured response.

This invention discloses a percutaneous spinal cord electrical stimulation (PCOS)-based analgesia system and method, belonging to the field of non-invasive electrical stimulation analgesia technology and its stimulation control system. The system includes: a single pair of electrode patches, comprising a cathode patch and an anode patch, for attachment to the subject's body surface in areas corresponding to target spinal cord segments; a stimulator electrically connected to the single pair of electrode patches for generating and outputting electrical stimulation signals to the electrode patches; and a control module connected to the stimulator for receiving user-input commands, setting and adjusting the stimulation parameters of the electrical stimulation signals, and controlling the activation and deactivation of the stimulator. This system features simple single-patch operation, precise targeting, and multi-segment coverage capabilities, providing a safe and controllable operating procedure for pain-related spinal cord segments through percutaneous electrical stimulation. Furthermore, the system's modular structure facilitates integration into different device platforms or expansion to other neuromodulation applications.

The subject matter of the present disclosure generally relates to techniques for applying mechanical or ultrasound energy to a region of interest in a subject to induce modulation of one or more nerve pathways. The region of interest may include at least a portion of a nerve ganglion.

The application relates to the technical field of electroencephalogram rehabilitation, and particularly discloses a depression neural regulation method and system based on TMS-EEG and machine learning driving, which comprises the following steps: S1: collecting electroencephalogram signals before transcranial magnetic stimulation of a patient; S2: pre-processing the electroencephalogram signals and extracting biomarker features; S3: inputting the extracted biomarker features into a trained machine learning model to obtain decision reference data; S4: using the above parameters as auxiliary reference data to adjust the transcranial magnetic stimulation control parameters; and S5: collecting the electroencephalogram signals again after the transcranial magnetic stimulation and using the electroencephalogram signals for optimizing subsequent personalized transcranial magnetic stimulation parameter suggestions. The application converts multi-time-point electroencephalogram signals into quantitative biomarkers, thereby providing doctors with objective decision reference data throughout the whole diagnosis and treatment process. This enables doctors to predict the patient's reactivity before stimulation regulation, thereby avoiding invalid stimulation; and the doctors can dynamically optimize the parameters according to the neurophysiological feedback during the stimulation, thereby realizing personalized and accurate regulation.

Disclosed is an H-bridge control circuit for an electro-stimulation therapeutic instrument for neuromodulation. The H-bridge control circuit includes an H-bridge circuit and a constant current source, where the H-bridge circuit includes a first positive channel metal oxide semiconductor (PMOS) transistor, a second PMOS transistor, a first negative channel metal oxide semiconductor (NMOS) transistor and a second NMOS transistor. Corresponding switching diodes are additionally arranged between the first PMOS transistor and a load and between the second PMOS transistor and the load to avoid an influence of safety of the therapeutic instrument by discharging charges during an interval of stimulation; and moreover, a resistance-capacitance (RC) circuit is additionally arranged between the first PMOS transistor, the second PMOS transistor and a control device such that connection and disconnection of the PMOS transistor can be controlled.

The present invention relates to a neuromodulation / neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: —at least one control unit (12) configured and arranged to provide stimulation data, and—at least one stimulation unit (14), operatively connected to the at least one control unit (12), said at least one stimulation unit (14) being configured and arranged to deliver epidural electrical stimulation to the spinal cord of said mammal, according to said stimulation data, wherein the at least one stimulation unit (14) includes a biocompatible implantable lead (18) configured and arranged to cover at least a portion of the spinal cord of said mammal to deliver epidural electrical stimulation to the dorsal roots innervating the spastic muscles to target neuronal circuitry responsible for spastic episodes.

The application relates to an integrated beat frequency ultrasonic neuromodulation system and a driving method thereof, and belongs to the technical field of neuromodulation and ultrasonic engineering. The application comprises a focused ultrasonic transducer module, a double-frequency signal generation module, a power amplification module, an impedance matching module, a control module, a power supply module and a neural electrophysiological acquisition module. The double-frequency signal generation module is electrically connected with the power amplification module, the power amplification module is electrically connected with the focused ultrasonic transducer module through the impedance matching module, the control module is in communication connection with the double-frequency signal generation module, the power amplification module and the neural electrophysiological acquisition module, and the power supply module provides working electric energy for each module. The application integrates double-frequency signal generation, power driving, impedance matching, transduction emission, signal acquisition and parameter control into the same system, adopts multiple ultrasonic carriers with different frequencies to share the same ultrasonic transducer of an acoustic aperture, makes focused sound spots located in the same area, and forms a stable beat frequency modulation field in the same physical aperture.

The application relates to a closed-loop nerve regulation system and method based on heart-brain interaction, which comprises four modules of multi-modal physiological signal acquisition, cross-modal feature fusion evaluation, Bayesian parameter optimization and median nerve electric stimulation output, can synchronously collect signs, fuse features to give scores, optimize stimulation parameters and apply electric stimulation, and forms a closed loop. Through the whole-link design of multi-modal signal synchronous acquisition, cross-modal feature intelligent fusion, stimulation parameter dynamic optimization and closed-loop electric stimulation intervention, the closed-loop nerve regulation system based on heart-brain interaction according to the embodiment of the application can effectively solve the core pain points of traditional consciousness disorder patient wake-up treatment, such as lack of real-time feedback, one-sided single-index evaluation, insufficient use of autonomic nervous signals and non-intelligent control of non-invasive stimulation, realize precise evaluation and individualized intervention, improve the wake-up efficiency, reduce the risk, and promote the data-driven change of nerve regulation.

This application relates to a neuromodulation device and an assembly for neuromodulation. The neuromodulation device includes a sealed housing assembly and electrodes. The sealed housing assembly includes an energy storage element, an output modulation element, and an electrode interface element. One end of the electrode is physically, electrically, and signalally connected to the sealed housing assembly via the electrode interface element. The other end of the electrode is arc-shaped and integrates one or more heating elements and a temperature sensing element; this other end is used for positioning near a target nerve. The neuromodulation assembly includes the neuromodulation device and an excitation device. The excitation device is used for energy emission and includes a control element, a waveform modulation element, and a emission element. The excitation device is operably connected to the neuromodulation device via the emission element in a wired or wireless manner.

The application relates to a stimulating coil for deep brain area nerve regulation, which is in an elliptical shape, has 6 turns, a short inner diameter of 5-15 mm, a long inner diameter of 15-40 mm, a wire width of 1.5 mm, a wire height of 1 mm, an axial spacing of 2 mm and a radial spacing of 1 mm. A transcranial magnetic stimulation system is electrically connected with two stimulating coils respectively. A transcranial magnetic stimulation method is used to symmetrically fix the two stimulating coils on the two sides of the head and make the stimulating coils close to the head; a power supply unit is used to rapidly discharge the two stimulating coils to induce a short strong pulse current in the stimulating coils and form a strong magnetic field of 1T-4T around the stimulating coils, so that the nucleus of the lamina and part of the hippocampus in the deep brain area are stimulated. The beneficial effect is that the stimulating effect on the deep brain area is excellent, especially in the aspect of accurately targeting specific brain areas, the nucleus of the lamina can be effectively stimulated, and part of the hippocampus can be touched.

A method of treating heart disease in a subject includes percutaneously introducing a catheter into vasculature of the subject. The catheter may include a neuromodulation element. The neuromodulation element may be positioned on a flexion element. The flexion element may deflect away from or toward a central axis defined by the catheter in response to an operator pulling or releasing a pull-wire. The neuromodulation element of the catheter can be positioned in a subclavian artery of the subject. The catheter can be used to selectively target and electrically stimulate at least one of a dorsal subclavian ansae or a ventral subclavian ansae. The method can include confirming stimulation of the dorsal subclavian ansae and / or the ventral subclavian ansae by monitoring a cardiac parameter. After confirming stimulation of the dorsal subclavian ansae and / or the ventral subclavian ansae, ablation energy can be provided to the dorsal subclavian ansae and / or the ventral subclavian ansae.

A conducting composition includes a topological polymer (e.g., a polyrotaxane polymer) and poly(3,4-ethylene-dioxy thiophene):polystyrene sulfonate (PEDOT:PSS). Devices may include a conducting layer including the conducting compositions, e.g., a device comprising a conducting layer, wherein the conducting layer includes a polyrotaxane polymer and a PEDOT:PSS array. The devices are useful in bioelectronics, including high-resolution electrophysiological monitoring of deformable tissues and localized neuromodulation for high-precision control of individual muscle activities.

The present application relates to the technical field of nerve monitoring, in particular to an intraoperative real-time feedback system and method for sacral nerve stimulation, the system comprising: a biological motion sensing unit for real-time monitoring of the body surface contraction movement of the perineum and perianal area and foot movement through a sensor and generating corresponding multi-modal sensing signals; a processing unit for receiving the multi-modal sensing signals and performing synchronization and feature extraction, inputting the extracted features into a pre-trained machine learning model to obtain a judgment result representing the effect of sacral nerve electrode implantation target point and the accuracy of the target point position; a feedback unit for receiving the judgment result and converting it into feedback information for unified display. The present application realizes objective quantitative evaluation through multi-modal signal synchronous perception and fusion, as well as integrated machine learning model, provides intelligent and predictive feedback beyond simple threshold judgment, and realizes precise guidance of electrode implantation.

An illustrative method includes: determining a preliminary estimate of the patient's tinnitus tone by allowing the patient to listen to and vary frequency and intensity of a first test tone within a predetermined first frequency range and a predetermined first intensity range to approximate the first test tone to the patient's tinnitus tone; defining a second frequency range and a second intensity range around the preliminary estimate of the patient's tinnitus tone; and determining a final estimate of the patient's tinnitus tone by allowing the patient to listen to and vary frequency and intensity of a second test tone within the second frequency range and the second intensity range to approximate the second test tone to the patient's tinnitus tone.

Methods and systems for improving medical conditions by delivering a focused ultrasound signal to target sites of the brain. The focused ultrasound signal can have a mechanical index of between about 1.0 to about 8.0 and / or an acoustic pressure of between about 1.0 MPa to about 3.0 MPa. The medical condition can comprise addiction (including binge eating), anxiety disorders and anxiety associated disorders, tinnitus, neurodegenerative disorders, neuropsychiatric disorders, cognitive disorders, neurodevelopmental disorders, post-traumatic stress disorder, stroke recovery, and combinations thereof.

In some embodiments, a method of providing a neurostimulation therapy to a patient comprises: generating, by an implantable pulse generator (IPG), electrical pulses comprising a plurality of pulses having a uniform pulse width over time and a pulse amplitude that changes over time, and applying the generated electrical pulses to neural tissue of the patient to inhibit neural activity of the patient. The pulse amplitude may change sinusoidally, linearly, or exponentially over time.

Systems, devices, and methods for treating drug-refractory epilepsy are disclosed. [Solution] In one embodiment, a method for treating epilepsy is disclosed, comprising detecting electrophysiological signals of a subject using a first electrode array coupled to a first intravascular carrier. The method further comprises analyzing the electrophysiological signals using a neuromodulator electrically coupled to the first electrode array, and stimulating a target site in the subject's body using a second electrode array coupled to a second intravascular carrier implanted in a portion of a body blood vessel above the base of the subject's skull.

A method for treating a neurological or psychiatric disorder in a subject is provided, including sequentially delivering low-intensity focused ultrasound (LIFU) neuromodulation to a plurality of brain targets while measuring one or more disease-related metrics, selecting, based on the measured metrics, a subset of brain targets exhibiting improvement satisfying a predefined selection criterion, and delivering high-intensity focused ultrasound (HIFU or sustained LIFU) neuromodulation to the selected subset to produce durable reduction of one or more disease signs or symptoms.

A method and a system are provided for determining a location of a brain target for neuromodulation therapy without requiring MRI imaging of the head. The system includes a sensor or a plurality of sensors configured to acquire data describing a geometry of a head of a subject. A processor is coupled to the sensor and is configured to receive the data describing a geometry of the head of the subject gathered by the sensor, determine 3D coordinates of head-surface contour points from the acquired data, apply a predictive model to the determined 3D coordinates of head-surface contour points, receive 3D coordinates of a located brain target as output from the model, and output 3D coordinates of the located brain target for subsequent delivery of neuromodulatory brain therapy. The model is pre-trained on a dataset of head and brain images and configured to associate head-surface coordinates with 3D coordinates of at least one deep brain target.

The present application relates to a kind of based on motor imagination trigger's electric stimulation synchronous closed loop multimodal neuroregulation system, belong to medical rehabilitation engineering and neural engineering technical field.The system includes: electroencephalogram signal acquisition and processing module, for real-time acquisition user sensory motor cortex electroencephalogram signal, and extract the event-related desynchronization features of motor imagination task in the electroencephalogram signal by time-frequency analysis model;Motor intention recognition and trigger module generates synchronous trigger signal;Functional electric stimulation module, through multi-channel electrode device drive surface electrode output electric stimulation pulse to target area, drive target action;Transcutaneous auricular vagus nerve electric stimulation module, output and motor intention duration synchronous stimulation pulse;Central control and synchronization module, for coordination control timing.Formed " intention recognition-synchronous control-assisted movement" complete closed loop, provides a kind of efficient, accurate, individualized neural engineering solution.

A device, system and method for the delivery of electrical stimulation for the treatment of acute or chronic pain and / or for the improvement of body function. There is described a neuromodulation electrode device including a substrate having a skin-facing surface and an electrode having at least one convex active surface projecting from the skin-facing surface of substrate for applying an electrical stimulation signal. A conductive gel layer having an electrode portion overlies the convex active surface(s) of the electrode. The substrate is formed of a conductive gel or the conductive gel layer further includes a substrate portion overlying the skin-facing surface of the substrate. The device further includes an isolating frame surrounding the perimeter of the electrode to provide electrical isolation between the electrode and the conductive gel substrate or from the substrate portion of the conductive gel layer.

The application relates to the technical field of neuromodulation devices, and provides a bone conduction neuromodulation device and a control method. The bone conduction neuromodulation device comprises an electroencephalogram acquisition device, a bone conduction vibration device and a control device. The control device is configured to extract electroencephalogram features in an electroencephalogram signal, determine vibration control parameters according to the electroencephalogram features, control the bone conduction vibration device to generate vibration according to the vibration control parameters, and adaptively adjust the vibration control parameters based on changes in the extracted electroencephalogram features during the process of generating vibration by the bone conduction vibration device, so as to form a closed-loop control. The closed-loop control mechanism based on real-time electroencephalogram feedback makes the vibration stimulation always adapt to the instant neural state of a target user, helps to reduce the influence of individual differences on the treatment effect, improves the stability and repeatability of the treatment effect, and further enhances the overall reliability of the bone conduction neuromodulation in clinical application.

This invention discloses a closed-loop adaptive transcranial interferometric stimulation method and system based on tTIS and fNIRS. The method includes: acquiring and analyzing relevant information to obtain the target region, core stimulation parameters, and required stimulation duration; configuring one or more stimulation units; attaching the stimulation units to their corresponding positions and calibrating the electrode contact impedance; controlling the electrodes to apply high-frequency stimulation signals to the target region corresponding to each stimulation unit based on frequency, phase, and amplitude tri-control technology; acquiring and processing cerebral blood oxygenation information in real time to obtain information to be analyzed; comparing and analyzing the information to be analyzed and adjusting the core stimulation parameters; repeating the above steps, and terminating stimulation when the current stimulation duration exceeds the required stimulation duration. This invention achieves precise and adaptive transcranial interferometric stimulation by acquiring cerebral blood oxygenation in real time and adjusting stimulation parameters in a closed loop, ensuring the safety and effectiveness of brain neuromodulation.