437 results about "Neuromodulation" patented technology

Methods and apparatuses are described for modulating multiple integrated neural networks to alter composite sensory processes, such as audition or hearing. These methods and apparatuses may be used for therapeutic and non-therapeutic uses, including enhancing entertainment and communication, by providing a cranio-cervical tuning apparatus worn in or around the outer ear or auricle. These methods and apparatuses may include functional neurosensory bias for neurosensory scrambling neuromodulation to influence composite or multi-modal sensory processes.

The invention provides an artificial intelligence spinal nerve regulation and control system and method based on a multi-modal physiology-nerve-experience closed loop, and relates to the technical field of medical instruments, the system comprises an implantable stimulation and sensing subsystem, a body surface and wearable sensing subsystem, a communication and time synchronization subsystem and a control processing unit, the implantable stimulation and sensing subsystem, the body surface / wearable sensing subsystem and the control processing unit are in communication connection in pairs through the communication and time synchronization subsystem. According to the method, the fundamental limitation that in the prior art, only dosage is maintained, and brain and subjective experience is ignored is broken through, and more stable, more efficient and more personalized accurate pain management is realized through multi-modal fusion and hierarchical cooperative control.

The invention belongs to the field of big data, and provides a wearable nerve regulation and control method and system based on cloud AI control, and the method comprises the steps: collecting user data through a wearable nerve regulation and control device worn on the limb part of a user, the user data being physiological data and / or motion data; uploading the user data to a cloud server, wherein the cloud server is provided with an artificial intelligence model; the artificial intelligence model receives the user data, and generates personalized nerve electrical stimulation parameters in combination with pre-stored user historical treatment data and / or medical history data; the cloud server issues the personalized nerve electrical stimulation parameters to the wearable nerve regulation and control device, and the wearable nerve regulation and control device executes transcutaneous nerve electrical stimulation operation based on the personalized nerve electrical stimulation parameters.

The invention provides a closed-loop nerve regulation and control system and method based on electroencephalogram detection. The defects that a traditional open-loop method lags in stimulation, equipment is heavy and the like are overcome. The system integrates an electroencephalogram acquisition module, an electroencephalogram analysis module, a remote program control module and a stimulation output module to form a closed-loop link. Through 32-channel 1kHz signal acquisition and 1-100Hz filtering pretreatment, pathological features are extracted in real time by using a deep convolutional neural network, stimulation parameters are modified through a remote program control module, and multi-channel collaborative stimulation and safe electrical stimulation are realized in combination with a time division multiplexing architecture and bipolar optocoupler isolation output. The method has the advantages that the pathological feature recognition accuracy of the deep convolutional neural network is greater than or equal to 95%, and the dynamic response delay is less than 50ms; a time division multiplexing hardware architecture is designed, multi-channel collaborative stimulation is achieved through a single DAC, and the size is reduced by 30%; + / -5V bipolar output is realized by using an optocoupler isolated H bridge driver, and the IEC 60601 medical safety standard is met; wireless regulation and control of stimulation parameters are supported, the long-term implantation requirement is met, and the risk of a secondary operation is reduced.

The invention relates to the field of virtual reality, in particular to an adaptive virtual reality cognitive training method and system. The method comprises the steps of obtaining a user individual information set and a real-time multi-modal physiological data stream, performing real environment three-dimensional reconstruction and relative and friend face modeling based on the user individual information set, and generating an individual virtual training scene; based on the real-time multi-modal physiological data flow and the individualized virtual training scene, nerve-behavior feature extraction and digital twinning dynamic modeling are carried out, and a user cognitive state evaluation information set is generated; based on the user cognitive state evaluation information set, training task parameter real-time optimization and virtual scene element dynamic adjustment are carried out through an adaptive strategy, and a cognitive enhancement intervention instruction set is generated; and based on the cognitive enhancement intervention instruction set, performing neural regulation intervention and training data closed-loop feedback, and generating and outputting an individualized cognitive training report. According to the method and the device, accurate self-adaptive intervention is realized in a virtual reality cognitive training process.

The invention provides a method for generating a personalized nerve regulation and control stimulation scheme, and aims to generate a precise nerve regulation and control stimulation scheme for an individual through an electroencephalogram evaluation result. The method comprises the following steps: firstly, constructing a scheme library containing a plurality of transcranial electrical stimulation basic schemes; secondly, collecting resting-state electroencephalogram signals of a user, extracting electroencephalogram characteristic indexes related to emotion, cognition and sleep, and comparing the electroencephalogram characteristic indexes with a norm database to judge cognition risks; generating a primary stimulation scheme according to an evaluation result, and if a cognitive risk exists, further detecting that a feature index is abnormal and generating a targeted correction scheme; all the schemes are subjected to priority ranking, and the sequence is determined according to the abnormal severity degree and the clinical weight; and finally, outputting a personalized treatment scheme sequence of one week. According to the method, the accuracy and effectiveness of treatment are improved, high individuation, systematicness, practicability and dynamic optimization potential are achieved, and powerful support is provided for nerve regulation and control treatment.

A neuromodulation lead that is biased towards a substantially omega shape when fully deployed is provided. The neuromodulation lead includes a left set of electrodes disposed on a left portion of the lead body of the neuromodulation lead and a right set of electrodes disposed on a right portion of the lead body of the neuromodulation lead. The neuromodulation lead can be positioned in the plane between the genioglossus muscle and the geniohyoid muscle.

The invention provides an acoustoelectric multi-mode nerve regulation and control method and system for improving the language reading ability, and the method comprises the steps: obtaining brain function activity baseline data based on a positioned abnormal link of the language reading ability of a pupil in combination with resting state and task state electroencephalograms; based on the abnormal links and the brain function activity baseline data, determining a TES target spot and a tFUS target region; starting a TES module based on the TES target spot and starting a tFUS module based on the tFUS target region; a tUS module is started to perform focused ultrasound stimulation intervention on the TES target spot and the tFUS target region and prompt the pupil to start a training task, and real-time electroencephalogram signals of the pupil in the intervention process and behavioral performance data of the pupil in the training task process are obtained; based on the real-time electroencephalogram signals and the behavioral performance data, the stimulation intensity of the tUS module on the TES target spot and the tFUS target region is adjusted. According to the invention, the synergistic interaction capability and the intervention accuracy are improved.

A visual synthesis-based virtual or augmented reality pain treatment apparatus and device. In the apparatus, an interaction control unit generates a pain stimulation scheme matching a current patient to be treated and sends the pain stimulation scheme to a data processing unit. The data processing unit, on the basis of the received pain stimulation scheme, generates a virtual reality environment and a virtual stimulation source visible to the patient in the virtual reality environment. A display unit displays the virtual reality environment and the virtual stimulation source to said patient. The data processing unit, on the basis of a pain category to be induced, determines a stimulation target of a limb and parameters of the virtual stimulation source. The display unit drives the virtual stimulation source to implement a visual approaching motion to the stimulation target of the patient so as to achieve non-real stimulation. The somatosensory system of the patient is activated by means of a vision-nerve coupling mechanism to induce the patient to feel a tactile sensation, a thermal sensation, and / or a cold sensation at the stimulation target and in a nearby area thereof, thereby achieving neuromodulation therapy of a pain pathway.

A closed-loop neuromodulation system includes at least one implantable neurostimulator configured to deliver electrical stimulation to a target nerve innervating a muscle; at least one biosignal sensor configured to detect a physiological signal associated with the target muscle, wherein the physiological signal may include an electromyographic (EMG) or electroneurographic (ENG) signal; and a controller operatively coupled to the neurostimulator and the sensor. The controller is configured to receive the physiological signal from the sensor, determine whether the signal satisfies a predefined condition indicative of weakness, strength, fatigue, muscle underactivity, or overstimulation, and, in response to detecting that the condition is satisfied, automatically adjust one or more stimulation parameters selected from amplitude, frequency, pulse width, train duration, or train count.

Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying the lungs to treat pulmonary medical conditions such as asthma. In one embodiment, the method may involve advancing an intravascular instrument to a target location in a blood vessel within the intercostal vasculature to ablate either or both the sympathetic afferent and efferent nerves lying within the paravertebral gutter including the visceral fibers that travel to the cardiothoracic cavity and abdominopelvic viscera and the T1 to T4 / 5 sympathetic chain. In another embodiment, an intravascular instrument may be advanced to the bronchial vessels to ablate either or both the sympathetic afferent and efferent nerves in and around the posterior pulmonary plexus. In one embodiment the ablative agent is a neurolytic agent delivered in a gel. This approach may be utilized to treat other cardiac and pulmonary diseases.

The invention relates to the field of closed-loop nerve regulation and function reconstruction, and discloses a closed-loop brain-spinal cord interface upper limb grasping function reconstruction method and system based on multi-modal biofeedback. According to the method, at least three kinds of feedback information such as joint angles, grabbing force and electromyographic signals are synchronously collected, and a comprehensive actual motion state is generated through weighted fusion; according to an error vector between an expected state and an actual state, a hierarchical adjustment strategy is creatively adopted to carry out differentiation and adaptive adjustment on parameters such as stimulation current intensity, frequency and pulse width; and fatigue indexes are calculated based on myoelectricity frequency domain characteristics (such as median frequency and average power frequency), and prospective intervention is carried out by superimposing a fatigue compensation strategy. The method effectively solves the problems that an existing system is low in control precision, insufficient in single feedback dimension information and insufficient in continuous motion ability, and the precision, adaptability and long-term stability of motion control are remarkably improved.

The invention relates to the technical field of nerve regulation and control, and discloses a nerve regulation and control method based on dynamic frequency band analysis, which is used for improving the accuracy of epileptic seizure judgment. The neural regulation and control method based on dynamic frequency band analysis comprises the following steps: acquiring a local field potential signal of a target brain region in a preset time period; performing dynamic frequency band analysis on the local field potential signal to obtain a pathological wave frequency band, a high-frequency oscillation band, a harmonic coupling band and a suppression wave band; calculating the energy ratio and the cross-band phase coupling strength of each feature sub-band, and generating a multi-dimensional feature vector; the epileptic seizure probability is calculated according to the multi-dimensional feature vector; and when the epileptic seizure probability is greater than a preset threshold value, selecting a corresponding stimulation parameter group according to the dominant characteristic sub-band type, and outputting an electrical stimulation pulse with a frequency band matching characteristic.

The invention provides a nerve regulation and control system and method for a spinal cord ventral epidural region, and the system employs a microprocessor to generate multiple paths of pulse width modulation signals, and drives a voltage-controlled current source after amplitude adjustment. Stimulation current with adjustable frequency, pulse width and amplitude is output to act on a spinal cord ventral nerve structure. Real-time monitoring of stimulation current of each channel is realized through combination of voltage sampling and a single-pole multi-throw analog switch, feedback information of a body position, myoelectricity, pressure and other multi-mode sensors is fused, a closed-loop control mechanism is constructed, and dynamic adjustment and individualized optimization of electrical stimulation parameters are realized. The system has the advantages of being more accurate in electrical stimulation positioning, more sensitive in response, more intelligent in control and the like, and is suitable for intelligent rehabilitation intervention in scenes of spinal cord injury, cerebral palsy, neurological dysfunction and the like.

The invention discloses an individualized precise brain regulation and control method and device based on dynamic brain network traceability, and relates to the technical field of electroencephalogram regulation and control. The method comprises the steps that resting state electroencephalogram signals of each lead of two resting state tasks are obtained; performing traceability analysis on the resting-state electroencephalogram signals of each lead of the two resting-state tasks, and calculating weighted phase lag indexes of lead pairs according to the traced resting-state data of the two leads in the pairwise lead pairs; constructing dynamic brain networks according to the weighted phase lag indexes of all lead pairs, performing modeling according to the first dynamic brain network and the second dynamic brain network, calculating an abnormal index of each brain region node, performing target stimulation based on the abnormal index of each brain region node by using a multi-channel stimulation controller, and performing target stimulation based on the abnormal index of each brain region node. According to the invention, the problems of inaccurate target spot positioning and single target spot in the existing cranial nerve regulation and control technology are solved.

The invention relates to the technical field of nerve regulation and control, in particular to a depressive state adjusting system and method based on transcranial electrical stimulation, and the method comprises the steps: collecting electroencephalogram signals of left and right brain frontal lobe areas of even-level leads; the method comprises the following steps: performing noise filtering on collected electroencephalogram signals of a left brain and a right brain, extracting 8-13Hz power spectrum data of Alpha waves of the left brain and the right brain, calculating a numerical difference value of power spectrums of the Alpha waves of the left brain and the right brain and an average proportion of the difference value in a test time period, and taking the numerical difference value and the average proportion as quantitative indexes of the depression-associated lateral deviation level; the adaptive transcranial electrical stimulation module is matched through the acquisition module according to basic information such as the age and the medical history of a patient, initial parameters are set, the parameters are dynamically corrected through the control module in combination with real-time physiological signals, accurate personalized treatment is achieved, and treatment safety can be guaranteed.

A neuromodulation system disclosed herein improves urethral function, provides personalized stimulating parameters, and allows the patients to regain control of their bladders according to several implementations. A neuromodulation system disclosed herein provides bilateral stimulation and sensing, and personalized machine learning classifiers for adaptive stimulation. The system may include one or more electrode leads implanted in a first lateral side of the patient and one or more second electrode leads implanted in a second lateral side of the patient opposite the first lateral side. Mixed urinary incontinence and other conditions are treated using electrical stimulation, according to several implementations.

The invention discloses a multifunctional neural electrode for intracranial pressure detection and closed-loop nerve regulation, the multifunctional electrode sequentially comprises a PMUT electrode for intracranial pressure detection and nerve regulation and a macro-micro electrode for electroencephalogram signal detection from top to bottom, and the PMUT electrode is bonded on the macro-micro electrode. The PMUT electrode is bonded to the macro-micro electrode to serve as a multifunctional electrode, the PMUT electrode can serve as a pressure sensor and can also serve as an ultrasonic transducer, the dual functions of intracranial pressure detection and fixed-point ultrasonic nerve stimulation are achieved, the macro-micro electrode can achieve detection of local field potential and peak potential, and the ultrasonic nerve stimulation function is achieved. Therefore, a detection-feedback-regulation closed-loop system is realized.

The invention relates to the technical field of nerve regulation and control, and discloses a nerve stimulation signal output control method and device, equipment and a storage medium, which are used for improving the accuracy of anomaly detection and the flexibility of nerve stimulation signal output control. The nerve stimulation signal output control method comprises the following steps: inputting an original cortex electroencephalogram signal and an original deep electroencephalogram signal into an anomaly analysis model for analysis, and outputting a target anomaly type and a corresponding anomaly degree; selecting a plurality of pulse groups which are arranged in sequence from a preset dynamic stimulation group library according to the target anomaly type and the corresponding anomaly degree, sequentially controlling the cortex electrode or the deep electrode to output the pulse groups, performing recovery detection among the pulse groups, and if the anomaly of the current detection period is continuous, determining that the current detection period is abnormal. And if the abnormality is detected, executing the next pulse group until all the pulse groups are output, if the abnormality is not detected, not executing the remaining pulse groups, and when the abnormality is detected in the next detection period, re-outputting a plurality of pulse groups in sequence.

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell.

Disclosed herein are methods and devices for transvascular placement of electrodes on a surface of a brain or in deep brain structures for the purpose of neuromodulation. The device can comprise a delivery catheter comprising a lumen. The device can comprise a piercing assembly extending through the delivery catheter, wherein the piercing assembly comprises a piercing assembly catheter and a needle. The device can comprise one or more electrodes configured to contact the brain tissue; and wherein the piercing assembly catheter comprises an opening in a wall thereof such that when the delivery catheter and the piercing assembly catheter are positioned within a vessel, the needle extends through the opening to puncture a vessel wall.

The invention discloses a three-dimensional electric field vector detection and microdialysis synchronous sampling implanted probe system, and belongs to the technical field of neural electrophysiology detection. The system comprises a vector electric field detection module (containing multiple layers of platinum-iridium alloy contacts) and a microdialysis module (provided with a semi-permeable membrane window with high selectivity and biological compatibility) which are coaxially integrated, and spatial isolation and synchronous acquisition of electro-chemical signals are realized through an insulating support structure. The problems of separation and spatial dislocation of an electric field detection and biochemical sampling system in the prior art are solved, real-time association of three-dimensional electric field vector reconstruction and neurotransmitter analysis is supported, and accurate electro-chemical coupling data is provided for nerve regulation and control research.

An intelligent interactive neuromodulation system by intravesical and pelvic floor stimulation is provided, including: an electromyography (EMG) acquisition module, an intelligent diagnostic module, a display interaction module, and an electrical stimulation module. The intelligent diagnostic module is configured to receive an original EMG signal acquired by the EMG acquisition module and obtain feature information, generate a first treatment protocol by using the feature information and a preconfigured intelligent fitting model, and generate a classification result of an abnormal bladder activity based on the feature information and a preconfigured intelligent classification model; in response to identifying that a detrusor activity of a patient changes, automatically complete dynamic switching between a first treatment mode and a second treatment mode. The display interaction module is configured to receive a first treatment protocol and a second treatment protocol, and send the first treatment protocol to the electrical stimulation module to apply electrical stimulation pulses.

Methods, systems, and devices, including computer programs encoded on a computer storage medium are provided for optimizing neurostimulation therapy for treatment of neurological and neurodegenerative diseases. Joint dynamic causal modeling and biophysics modeling are used for optimization of the stimulation targets and parameters. In particular, methods of performing neuromodulation to suppress b-band oscillations in the brain of a subject are provided.

Provided are systems, methods, and devices for providing mediation or alleviation of sleep disorders and insomnia. Systems may include an interface, processing devices, and a controller. The interface is configured to obtain measurements from a brain of a user with sleeping disorders and insomnia. A first processing device is configured to generate multiple brain state parameters characterizing one or more features of a brain state of the user. A second processing device is configured to generate models of the brain of the user based on the plurality of brain state parameters and the plurality of measurements, and determine, using the models and training data comprising one or more mediation data points, a mediation procedure for reducing one or more symptoms of the sleeping disorder or insomnia. The mediation procedure is provided to one or more entities, and one or more control signals are generated by the controller based on the mediation procedure.

Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and / or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

The invention relates to the technical field of nerve regulation and control, and discloses a brain wave frequency modulation instrument which comprises a wearing shell and two groups of brain wave frequency modulation optimization modules which are integrally mounted at two ends of the wearing shell and are configured to acquire brain wave signals of a user in real time, according to the brain wave frequency modulation instrument, the defect of single-frequency static stimulation of traditional equipment is overcome, personalized brain wave regulation and control are achieved through the AI algorithm, and the brain wave frequency modulation instrument has the advantages that the brain wave frequency modulation instrument is simple in structure, convenient to use and high in practicability. Frequency conversion guide field signals can be dynamically matched with the brain wave state of a user, and the central control module can adaptively regulate and control multi-module combination. According to the equipment, brain wave optimization, purification and energizing are synchronously carried out, a closed-loop feedback system improves regulation and control accuracy, the wearable design is portable and easy to use, brain wave disorder can be accurately improved, anxiety and fatigue can be relieved, and multi-directional guarantee is provided for physical and psychological health.

Systems and methods for reliably returning a neuromodulation system to a predetermined position relative to a user's head is disclosed. The system includes a neuromodulation device and a stimulation control computing environment. The stimulation control computing environment can be configured with data processing functions to focus ultrasound emission to a target brain region. The system identifies an initial position of one or more ultrasound-emitting elements with respect to the head of a user, uses brain images to identify the target brain region, and performs acoustic simulations to focus ultrasound emissions from the initial position to the target brain region. The distance between an inner surface of the device and a user's head can be measured, and one or more spacing elements can be placed on the inner surfaces based on the measured distances, which enables the reliable return of the neuromodulation device to the initial position with minimal displacement.

The invention relates to an ejaculation control nerve regulation and control method and device based on electric pulse dynamic adjustment, and belongs to the field of medical instrument electronic products, and the method comprises the steps: S1, judging whether the positions of two electrodes are effective stimulation positions or not according to the collected contact resistance of the two electrodes at the dorsal root of the penis for stimulating the dorsal root of the penis; if so, entering the next step; otherwise, adjusting the positions of the two electrodes until the effective positions are judged, and then entering the next step; s2, selecting at least one working mode of a high-frequency mode, a low-frequency mode, a frequency mixing mode, a frequency mixing group mode and a modulation frequency mixing mode, and outputting electric pulse signals corresponding to the frequency modes to the dorsal root nerves of the penis through the two electrodes for electrical stimulation; s3, in the electrical stimulation process, according to the collected contact resistance values of the two electrodes, the output energy of the electric pulse signal is dynamically adjusted, and the dynamic balance of the charging and discharging process is controlled; therefore, the effectiveness and safety of electrical stimulation are ensured. The ejaculation control nerve regulation is safer and more effective.

A method and device for treating tinnitus and / or hearing impairment of a user at bedtime includes providing an audio stimulus to the user using a parametric array speaker. Some embodiments treat tinnitus by removing a frequency notch corresponding to the user's tinnitus frequencies from the audio signal. The audio signal may be ambient sound detected by a microphone, or may be a prerecorded file which may comprise noise or other audio such as audiobooks or music. Some embodiments combine treatment of tinnitus or hearing impairment with treatment for apnea, hypopnea or snoring.