79 results about "Joint disease" patented technology

The present application relates to the technical field of joint cavity positioning, and specifically provides a joint cavity positioning method and device based on a deep learning model, the method comprising the steps of: S1, acquiring an arthroscopic image, and preprocessing the arthroscopic image to obtain an enhanced image; S2, acquiring joint cavity position information based on a pre-trained joint cavity positioning model and the enhanced image; the pre-training of the joint cavity positioning model comprises: A1, training a pre-built deep learning model using a pre-collected general medical image dataset to obtain a preliminary positioning model; A2, expanding a pre-collected arthroscopic image dataset of rare bone and joint diseases to obtain an expanded image dataset, and then dynamically adjusting the regularization strength of the preliminary positioning model based on an adaptive regularization coefficient function according to the joint cavity morphological diversity index of the expanded image dataset to obtain a joint cavity positioning model; the method can accurately locate the joint cavity of rare bone and joint diseases.

This invention provides a composition for improving bone and joint health, its preparation method, and its application, relating to the field of bone and joint health products technology. By weight, the composition for improving bone and joint health comprises the following components: 0.5-5 parts collagen peptides, 5-30 parts mangosteen extract, 0.5-3 parts non-denatured type II collagen peptides, 0.1-2 parts milk mineral salts, 0.3-3 parts bone collagen peptides, 0.1-2 parts cartilage extract, 0.1-2 parts N-acetylglucosamine, 0.1-2 parts sodium hyaluronate, and 0.3-3 parts turmeric extract. This invention, through multiple combinations of mangosteen extract and turmeric extract, and cartilage extract and sodium hyaluronate, obtains a composition that is low in cost, highly safe, and has a good effect on the prevention or improvement of bone and joint diseases.

The invention discloses a portable detection system for early diagnosis of orthopaedic joint diseases, and relates to the technical field of orthopaedic joint disease diagnosis, which comprises the following steps: acquiring acoustic and motion feature vectors of joint activities, calculating a quality score based on an acoustic signal-to-noise ratio and a motion goodness of fit, performing weighted splicing on features by taking the quality score as a weight after normalization, generating a fusion feature vector; thirdly, reconstructing features by using a reverse decoding model, comparing the same degree with the original features, weighting to obtain fusion same degree, and iteratively adjusting the weight to optimize the fusion effect; and performing clustering analysis on the candidate feature vectors, replacing the candidate feature vectors if the candidate feature vectors deviate from a clustering center, and finally inputting a health model to output a diagnosis report. Through dynamic weighting of quality scores, high-fidelity features are processed preferentially, the information density and discrimination capability are improved, and low-quality data interference is reduced; and self-checking and dynamic correction are realized through reconstruction and similarity comparison, so that the fidelity and consistency of the characteristics are ensured, and the robustness of the system is enhanced.

The invention relates to the technical field of osteoarticular diseases, in particular to an artificial intelligence auxiliary diagnosis and treatment system for osteoarticular diseases based on an internet hospital. Comprising an information management module; an intelligent diagnosis auxiliary module; a remote monitoring and rehabilitation guidance module; a disease risk prediction module; according to the system, a comprehensive system covering functions of information acquisition, data integration, image analysis, rehabilitation tracking and the like is constructed, so that whole-process information of a patient from a doctor seeing period to a rehabilitation period is systematically managed, and the continuity and personalized service level of diagnosis and treatment are effectively improved; and artificial intelligence technologies such as deep learning, natural language processing and knowledge graph are applied to automatically complete bone joint image recognition, symptom analysis and rehabilitation plan making, so that the diagnosis efficiency and accuracy of doctors are greatly improved, and meanwhile, dynamic adjustment and refined guidance of the rehabilitation plan are realized.

The invention provides a pharmaceutical composition for bone joints as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight: 20 to 2000 parts of N-acetylglucosamine and 10 to 1000 parts of non-denatured type II collagen. In the compound composition of the N-acetylglucosamine and the non-denatured type II collagen, the two core components play a complementary role: the N-acetylglucosamine is focused on promoting synthesis of a cartilage matrix and provides a material basis for cartilage repair; the non-denatured type II collagen reduces damage of autoimmune response to cartilage through immunoregulation, the non-denatured type II collagen and the non-denatured type II collagen have a synergistic effect, the symptoms such as arthralgia and swelling can be relieved, the joint structure can be improved from the double angles of repairing and protecting, and particularly the treatment effect on patients with severe osteoarthritis is remarkably superior to that of a single-component preparation; and an innovative and efficient choice is provided for the treatment of osteoarticular diseases.

The invention provides a temporal-mandibular joint disease diagnosis method and system based on a large language model, and the method comprises the steps: collecting text data of a temporal-mandibular joint disorder syndrome, carrying out the preprocessing of the text data, obtaining a temporal-mandibular joint disease professional data set, and employing a pre-trained large language model to extract metadata; segmenting the extracted metadata into text blocks by adopting a self-adaptive semantic partitioning algorithm, and obtaining a set of the text blocks, namely a text block library; constructing a temporal-mandibular joint special disease knowledge map; according to the type of a user query statement and a knowledge graph, integrating direct semantic search and knowledge graph guide search by adopting a mixed search strategy, and performing knowledge retrieval and reasoning to obtain retrieval information; after retrieval information is input into the fine-tuned large language model, a diagnosis result is generated; according to the method, higher diagnosis accuracy can be achieved, intelligent auxiliary diagnosis of the temporomandibular joint disease can be achieved, and the accuracy and reliability of diagnosis of the temporomandibular joint disease can be improved.

Disclosed is a composition for treating a joint disease or a connective tissue disease, a composition for cartilage regeneration, or a composition for treating an inflammatory disease, each of the compositions containing dextran, poloxamer or a mixture thereof. The composition stays in the joint or connective tissue for a long time due to the shock-absorbing effect, coating effect or anti-inflammation effect, relieves the shock, covers a damaged portion in a specific manner thereto, or reduces inflammation of an adhered portion. Thus, the composition may be useful for the treatment of the joint disease, the connective tissue disease, or for the cartilage regeneration.

The invention discloses a portable hot compress medicine carrying device for treating temporomandibular arthropathy, which comprises a main body part provided with a placing cavity; the medicine carrying assembly is arranged in the placing cavity; the ear hook is connected to the side of the main body part so as to be hung on the ear, so that the medicine carrying assembly faces the temporomandibular joint; the medicine carrying assembly comprises a medicine box, a sponge layer and a graphene heating layer, the sponge layer is arranged between the medicine box and the graphene heating layer, and liquid medicine in the medicine box is conveyed to the graphene heating layer arranged towards the temporomandibular joint through the sponge layer; the graphene heating layer is electrified to emit far infrared waves, so that blood circulation of the temporomandibular joint area is promoted through heat radiation, and percutaneous release of liquid medicine is enhanced. According to the medicine carrying device, through heat radiation of the graphene heating layer, local blood circulation of the temporomandibular joint is improved, skin permeability is improved, and medicine penetrates through the skin to enter subcutaneous tissue or muscular tissue.

The invention relates to the field of medicine, and more particularly to medicinal agents for treating joint diseases. An agent for treating joint diseases includes an effective amount of chondroitin sodium sulphate and at least one adjuvant or carrier, and further contains iron in a relative amount of from 1 mg / kg to 40 mg / kg, calculated on the basis of the mass of chondroitin sodium sulphate.

The present invention provides a pharmaceutical composition for treating arthropathy, the pharmaceutical composition comprising a composition containing extracellular vesicles derived from a culture supernatant of mesenchymal stem cells, the pharmaceutical composition being characterized in that the culture medium for the mesenchymal stem cells satisfies the following conditions: (1) the culture medium is a culture medium having defined components; the composition does not contain animal-derived components of species different from those of a treated object; and (2) the number of fine particles having a particle diameter of 1-1000 nm is less than 1 * 109 particles / mL in a state prior to use.

An image diagnostic device (100) comprises: a bony acetabular line detection unit (153) that detects, on the basis of a pixel value of each pixel of an ultrasonic image acquired by an acquisition unit (152), a bony acetabular line in the ultrasonic image; and a baseline detection unit (154) that detects, on the basis of the pixel value of each pixel of the ultrasonic image acquired by the acquisition unit (152), a straight line indicating an iliac outer wall in the ultrasonic image and detects a baseline parallel to the detected straight line indicating the iliac outer wall and passing through a bony acetabulum or a lower end of the iliac outer wall at an end portion of the bony acetabular line detected by the bony acetabular line detection unit (153).

Disclosed are methods for detecting extracapsular synovial fluid or components thereof as a marker for initiation of processes that lead to degenerative joint disease in a subject.

The invention relates to a composition containing a glucosamine derivative, which comprises the following components based on the total weight of the composition: 55-70 wt%, preferably 55-65 wt%, more preferably 60-65 wt% of a compound as shown in a formula (I) or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable auxiliary materials. The invention also relates to application of the compound in preparation of a medicine for preventing or treating bone or joint diseases of a subject in need of the compound.

The invention discloses a multi-level targeting composite hydrogel microsphere based on amino fullerene and an application of the multi-level targeting composite hydrogel microsphere based on amino fullerene, methylacrylate modified aldehyde hyaluronic acid is used as a matrix carrier, amino fullerene is combined with the matrix carrier, and the methylacrylate modified aldehyde hyaluronic acid-fullerene composite hydrogel microsphere is obtained. The macroscopic-cell-mitochondrial multi-layer slow-release targeting effect is achieved, ROS is remarkably reduced in vitro / in vivo, and cartilage repair is promoted. Compared with the prior art, the invention has remarkable innovativeness in targeting precision, release control and curative effect, and is suitable for precise treatment of joint diseases.

The invention belongs to the technical field of important compositions, and particularly relates to a traditional Chinese medicine composition for treating muscle and bone diseases, a traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials: radix angelicae pubescentis, ligusticum wallichii, rhizoma sparganii, rhizoma atractylodis macrocephalae, peach kernels, radix angelicae sinensis, flos daturae, radix paeoniae rubra, radix angelicae, unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, unprocessed rhizoma pinelliae, unprocessed rhizoma arisaematis, flos carthami, unprocessed radix rehmanniae, radix et rhizoma rhei, fructus forsythiae, trogopterus dung, unprocessed radix astragali, unprocessed semen strychni, rhizoma et radix notopterygii, unprocessed radix glycyrrhizae, drynaria baronii, frankincense, myrrh and storax. Aiming at the technical problems of single effect and limited curative effect of the existing plaster, the plaster disclosed by the invention combines the functions of eliminating evil and strengthening the body resistance through scientific formula compatibility, and realizes the synergistic effect of multiple effects of clearing heat, tonifying qi, activating blood, dredging collaterals and the like, so that the treatment of the plaster is more comprehensive and deep, and the plaster has a remarkable curative effect on chronic and intractable muscle and bone diseases.

The present disclosure provides improved methods, therapeutic regimens, and systems for treating a disease associated with a pituitary malignancy in a subject, such as treating Cushing Syndrome, or treating one or more symptoms of Cushing Syndrome in subjects, through the inhibition of extracellular diazepam binding inhibitor (DBI) by various methods. The present disclosure also relates to compositions for use and methods in treating synovial inflammation in a subject, the compositions for use and methods comprising an agent that reduces human diazepam binding inhibitor (DBI) activity or expression. The present disclosure also relates to compositions for use and methods in treating degenerative joint disease, joint inflammation, and manifestations thereof in a subject, the compositions for use and methods comprising an agent that reduces human diazepam binding inhibitor (DBI) activity or expression.

The invention discloses a hip joint cartilage non-uniform multi-section feature three-dimensional reconstruction method, and belongs to the field of medical image three-dimensional digital modeling and orthopedic biomechanical technology research. According to the method, hip joint dysplasia is taken as a research object, and boundary segmentation and reconstruction of a three-dimensional geometric model of bone tissue are carried out through CT (Computed Tomography); based on a nuclear magnetic resonance image and an anatomical structure, computer-aided software and a curve fitting method are utilized to reconstruct a high-precision hip joint cartilage three-dimensional geometric model with inner and outer contours and non-uniform thickness, and finally a hip joint-cartilage three-dimensional model is constructed in an origin registration mode. According to the method, the multi-section feature three-dimensional model of the hip joint cartilage can be accurately and efficiently reconstructed, irregular curved surfaces of the cartilage reconstruction model are effectively reduced, and finite element mesh division and surface contact calculation of the hip joint are facilitated; and a high-precision cartilage three-dimensional digital model reference is provided for clinical diagnosis and treatment, rehabilitation, prosthesis design and biomechanical analysis of hip joint diseases.

The present disclosure provides compositions and methods for treating and preventing localized nociception, inflammation, or morphological changes associated with joint disease or illness, back or spine conditions or disorders, and musculoskeletal diseases or dysfunction.

The invention provides a rheumatism immune arthropathy rehabilitation physiotherapy device, and relates to the technical field of joint disease rehabilitation physiotherapy, the rheumatism immune arthropathy rehabilitation physiotherapy device comprises a physiotherapy fumigation assembly, the physiotherapy fumigation assembly is a closed cavity formed by a physiotherapy fumigation cover and a sealing layer through a hot melting technology, and an adjustable bandage is integrated on the outer surface of the physiotherapy fumigation cover; the flow guide mechanism is used for heating the concentrated liquid medicine and conveying effective components in the liquid medicine to pass through the joint surface through airflow to promote absorption of the medicine by the skin outside the joint, and heat in the gaseous liquid medicine is used for continuously preserving heat of the joint so as to realize the effects of hot compress and fumigation. Loss of effective components in the liquid medicine can be reduced, indoor air pollution caused by diffusion of peculiar smell of the liquid medicine is reduced, and the problems that most of liquid medicine steam cannot make contact with joints of a patient, steam dispersion causes large waste, the effective utilization rate of the liquid medicine is low, and peculiar smell generated by steam diffusion affects indoor air are solved.

This application discloses compounds, compositions, and uses for the prevention or treatment of canine bone or joint diseases. The compounds are those represented by formula (A) and their pharmaceutically acceptable salts and esters, wherein R is an amino acid.

The invention provides a traditional Chinese medicine preparation for treating bilateral knee joint osteoarthropathy, which is prepared by extracting the following traditional Chinese medicines in parts by weight: 15-25 parts of rhizoma acori graminei, 20-30 parts of polygala tenuifolia, 18-22 parts of prepared rehmannia root, 15-25 parts of dogwood, 10-20 parts of glossy privet fruit, 15-25 parts of semen cuscutae, 8-12 parts of coptis chinensis and the like. The traditional Chinese medicine composition has the effects of inducing resuscitation and eliminating phlegm, inducing resuscitation and benefiting intelligence, enriching blood and nourishing yin, nourishing liver and kidney, discharging heart fire, promoting kidney water to be used as heart, promoting blood circulation, nourishing blood and harmonizing blood, invigorating spleen and replenishing qi, and lifting qi of liver and spleen, and can be used for jointly treating bilateral knee joint osteoarthropathy caused by deficiency of liver and kidney. The traditional Chinese medicine preparation and granules prepared by the invention are excellent in dissolubility, relatively good in flowability, remarkable in curative effect, non-toxic, simple and convenient to use, easy to accept by patients and suitable for popularization.

The present invention relates to a pharmaceutical composition for preventing or treating cartilage disease or inflammatory joint disease and a method for preparing a chondrospheroid having chondrocyte differentiation ability. The present invention provides a pharmaceutical composition comprising a stem cell-derived spheroid as an active ingredient for preventing or treating cartilage disease or inflammatory joint disease, and a method for preparing a chondrospheroid having chondrocyte differentiation ability, the method comprising the steps of: Inoculating stem cells into a three-dimensional (3D) cell culture vessel made of a plastic material; treating the stem cells inoculated into the 3D cell culture vessel with a chondrocyte differentiation-inducing factor; culturing the stem cells treated with the chondrocyte differentiation-inducing factor to form chondrospheroids; and separating the formed chondrospheroids.

The present invention provides a pharmaceutical composition for preventing or treating cartilage / bone / joint diseases, the pharmaceutical composition containing, as active ingredients, a substance that inhibits the signal transduction of semaphorin 4D-plexin B2, for example: a substance that inhibits the binding of plexin-B2 and semaphoring 4D; a substance that inhibits the binding of c-Met and semaphorin 4D; a substance that inhibits the binding of plexin B2 and Traf2; and a substance that inhibits the binding of plexin B2 and c-Met. In addition, the present invention provides a method for screening a drug for preventing or treating cartilage / bone / joint diseases, the method comprising a step for selecting a substance to be tested that inhibits the signal transduction of semaphorin 4D-plexin B2.

The invention provides a tendon-relaxing and blood-activating composition, a tendon-relaxing and blood-activating extract, a preparation and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The composition for relaxing the muscles and stimulating the blood circulation comprises gentiana macrophylla, speranskia tuberculata, cassia twig, eucommia ulmoides, rhizoma atractylodis, radix aconiti, myrrh, salvia miltiorrhiza, divaricate saposhnikovia root, the root of kudzu vine, safflower carthamus, the root of bidentate achyranthes, notopterygium root, rhizoma drynariae, fermented rheum officinale and fermented hiraute shiny bugleweed herb. The pharmaceutical composition can effectively relieve, treat and prevent joint diseases, and is good in stability and convenient to store for a long time.

The invention discloses a traditional Chinese medicine composition for treating joint diseases and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25 to 45 parts of radix angelicae pubescentis, 25 to 45 parts of cortex phellodendri, 20 to 40 parts of rhizoma smilacis glabrae, 20 to 40 parts of rhizoma dioscoreae septemlobae, 20 to 40 parts of rhizoma chuanxiong, 20 to 40 parts of semen coicis, 20 to 40 parts of radix cyathulae, 20 to 40 parts of herba artemisiae scopariae, 20 to 40 parts of herba lycopodii, 20 to 40 parts of rhizoma polygoni cuspidati, 20 to 40 parts of radix dipsaci, 20 to 40 parts of rhizoma atractylodis, 20 to 40 parts of semen plantaginis and 10 to 25 parts of liquorice root. The traditional Chinese medicine composition has a relatively good treatment effect on gout, rheumatic arthritis and rheumatoid arthritis, can treat both symptoms and root causes, and is relatively small in side effect and relatively small in harm to a human body.

The present invention relates to GLP-1 receptor agonist compounds having an additional agonist activity over the GIP receptor and / or an agonist activity over the glucagon receptor and / or an antagonist activity over the GIP receptor for use in the treatment of joint diseases and / or joint pain and selected from the group comprising retatrutide, tirzepatide, orforglipron, mazdutide, efinopegdutide, froniglutide, maridebart cafraglutide, survodutide, efpeglenatide, ecnoglutide, efocipegtrutide and UBT251. The invention also relates to a pharmaceutical composition comprising at least one of the above mentioned GLP-1 receptor agonist compound, and a pharmaceutically acceptable excipient, for use in the treatment of joint diseases and / or joint pain.

This invention relates to a recombinant human secretory DDRGK1-Fc and its applications. Through experimental verification, the invention synthesizes recombinant human secretory DDRGK1-Fc, which has good bone-promoting function and is applied to the preparation of drugs for treating bone and joint-related diseases, promoting cartilage formation, and promoting intervertebral disc formation. This opens up new ideas for the treatment of bone and joint diseases and has obtained relatively solid scientific evidence.

The present invention provides a composition comprising an anionic lipid composition and a polycationic aggregating agent for use in the intra-articular treatment of a joint disease or disorder, such as osteoarthritis. In addition, a kit for preparing the composition and a novel composition comprising the anionic lipid composition and a polycationic aggregating agent are also provided.

The present disclosure relates to a food composition including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) for use in a method for treating and / or preventing a chronic inflammatory joint disease in a companion animal, particularly a canine or a feline, in need thereof, wherein the mass ratio of EPA to DHA is from about 0.2:1 to about 1:1, and the total amount of EPA and DHA is from about 0.1 g / Mcal to about 20 g / Mcal.

The invention discloses a novel invisible appliance for treating temporomandibular joint disease pain, which relates to the field of medical instruments and comprises a rear tooth socket, an upper jaw invisible appliance and a lower jaw invisible appliance, the rear tooth socket is arranged at the rear ends of the invisible upper jaw appliance and the invisible lower jaw appliance, an upper jaw pad is arranged at the bottom end of the invisible upper jaw appliance, and a lower jaw pad is arranged at the top end of the invisible lower jaw appliance; canine tooth sleeves are arranged on the upper jaw invisible orthodontic appliance and the lower jaw invisible orthodontic appliance, a traction hook is arranged at one end of each canine tooth sleeve, and an elastic traction ring is arranged on the periphery of each traction hook; the posterior tooth interlocking structure and the anterior tooth vertical traction structure are integrated into the invisible orthodontic appliance, so that orthodontic treatment and temporomandibular joint disease pain treatment are integrated, the treatment period is shortened, and patient compliance is improved; the V-M interlocking structure accurately locks the lower jaw, the vertical traction realizes condylar process reduction, the pain is relieved from pathogenesis, the digital design can realize personalized adaptation, and the double stable curative effects of correction and pain treatment are ensured.