49 results about "Joint disease" patented technology

The invention discloses a portable detection system for early diagnosis of orthopaedic joint diseases, and relates to the technical field of orthopaedic joint disease diagnosis, which comprises the following steps: acquiring acoustic and motion feature vectors of joint activities, calculating a quality score based on an acoustic signal-to-noise ratio and a motion goodness of fit, performing weighted splicing on features by taking the quality score as a weight after normalization, generating a fusion feature vector; thirdly, reconstructing features by using a reverse decoding model, comparing the same degree with the original features, weighting to obtain fusion same degree, and iteratively adjusting the weight to optimize the fusion effect; and performing clustering analysis on the candidate feature vectors, replacing the candidate feature vectors if the candidate feature vectors deviate from a clustering center, and finally inputting a health model to output a diagnosis report. Through dynamic weighting of quality scores, high-fidelity features are processed preferentially, the information density and discrimination capability are improved, and low-quality data interference is reduced; and self-checking and dynamic correction are realized through reconstruction and similarity comparison, so that the fidelity and consistency of the characteristics are ensured, and the robustness of the system is enhanced.

The invention provides a temporal-mandibular joint disease diagnosis method and system based on a large language model, and the method comprises the steps: collecting text data of a temporal-mandibular joint disorder syndrome, carrying out the preprocessing of the text data, obtaining a temporal-mandibular joint disease professional data set, and employing a pre-trained large language model to extract metadata; segmenting the extracted metadata into text blocks by adopting a self-adaptive semantic partitioning algorithm, and obtaining a set of the text blocks, namely a text block library; constructing a temporal-mandibular joint special disease knowledge map; according to the type of a user query statement and a knowledge graph, integrating direct semantic search and knowledge graph guide search by adopting a mixed search strategy, and performing knowledge retrieval and reasoning to obtain retrieval information; after retrieval information is input into the fine-tuned large language model, a diagnosis result is generated; according to the method, higher diagnosis accuracy can be achieved, intelligent auxiliary diagnosis of the temporomandibular joint disease can be achieved, and the accuracy and reliability of diagnosis of the temporomandibular joint disease can be improved.

Disclosed is a composition for treating a joint disease or a connective tissue disease, a composition for cartilage regeneration, or a composition for treating an inflammatory disease, each of the compositions containing dextran, poloxamer or a mixture thereof. The composition stays in the joint or connective tissue for a long time due to the shock-absorbing effect, coating effect or anti-inflammation effect, relieves the shock, covers a damaged portion in a specific manner thereto, or reduces inflammation of an adhered portion. Thus, the composition may be useful for the treatment of the joint disease, the connective tissue disease, or for the cartilage regeneration.

The invention relates to the field of medicine, and more particularly to medicinal agents for treating joint diseases. An agent for treating joint diseases includes an effective amount of chondroitin sodium sulphate and at least one adjuvant or carrier, and further contains iron in a relative amount of from 1 mg / kg to 40 mg / kg, calculated on the basis of the mass of chondroitin sodium sulphate.

The present invention provides a pharmaceutical composition for treating arthropathy, the pharmaceutical composition comprising a composition containing extracellular vesicles derived from a culture supernatant of mesenchymal stem cells, the pharmaceutical composition being characterized in that the culture medium for the mesenchymal stem cells satisfies the following conditions: (1) the culture medium is a culture medium having defined components; the composition does not contain animal-derived components of species different from those of a treated object; and (2) the number of fine particles having a particle diameter of 1-1000 nm is less than 1 * 109 particles / mL in a state prior to use.

An image diagnostic device (100) comprises: a bony acetabular line detection unit (153) that detects, on the basis of a pixel value of each pixel of an ultrasonic image acquired by an acquisition unit (152), a bony acetabular line in the ultrasonic image; and a baseline detection unit (154) that detects, on the basis of the pixel value of each pixel of the ultrasonic image acquired by the acquisition unit (152), a straight line indicating an iliac outer wall in the ultrasonic image and detects a baseline parallel to the detected straight line indicating the iliac outer wall and passing through a bony acetabulum or a lower end of the iliac outer wall at an end portion of the bony acetabular line detected by the bony acetabular line detection unit (153).

Disclosed are methods for detecting extracapsular synovial fluid or components thereof as a marker for initiation of processes that lead to degenerative joint disease in a subject.

The invention relates to a composition containing a glucosamine derivative, which comprises the following components based on the total weight of the composition: 55-70 wt%, preferably 55-65 wt%, more preferably 60-65 wt% of a compound as shown in a formula (I) or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable auxiliary materials. The invention also relates to application of the compound in preparation of a medicine for preventing or treating bone or joint diseases of a subject in need of the compound.

The invention discloses a multi-level targeting composite hydrogel microsphere based on amino fullerene and an application of the multi-level targeting composite hydrogel microsphere based on amino fullerene, methylacrylate modified aldehyde hyaluronic acid is used as a matrix carrier, amino fullerene is combined with the matrix carrier, and the methylacrylate modified aldehyde hyaluronic acid-fullerene composite hydrogel microsphere is obtained. The macroscopic-cell-mitochondrial multi-layer slow-release targeting effect is achieved, ROS is remarkably reduced in vitro / in vivo, and cartilage repair is promoted. Compared with the prior art, the invention has remarkable innovativeness in targeting precision, release control and curative effect, and is suitable for precise treatment of joint diseases.

The invention belongs to the technical field of important compositions, and particularly relates to a traditional Chinese medicine composition for treating muscle and bone diseases, a traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials: radix angelicae pubescentis, ligusticum wallichii, rhizoma sparganii, rhizoma atractylodis macrocephalae, peach kernels, radix angelicae sinensis, flos daturae, radix paeoniae rubra, radix angelicae, unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, unprocessed rhizoma pinelliae, unprocessed rhizoma arisaematis, flos carthami, unprocessed radix rehmanniae, radix et rhizoma rhei, fructus forsythiae, trogopterus dung, unprocessed radix astragali, unprocessed semen strychni, rhizoma et radix notopterygii, unprocessed radix glycyrrhizae, drynaria baronii, frankincense, myrrh and storax. Aiming at the technical problems of single effect and limited curative effect of the existing plaster, the plaster disclosed by the invention combines the functions of eliminating evil and strengthening the body resistance through scientific formula compatibility, and realizes the synergistic effect of multiple effects of clearing heat, tonifying qi, activating blood, dredging collaterals and the like, so that the treatment of the plaster is more comprehensive and deep, and the plaster has a remarkable curative effect on chronic and intractable muscle and bone diseases.

The present disclosure provides compositions and methods for treating and preventing localized nociception, inflammation, or morphological changes associated with joint disease or illness, back or spine conditions or disorders, and musculoskeletal diseases or dysfunction.

This application discloses compounds, compositions, and uses for the prevention or treatment of canine bone or joint diseases. The compounds are those represented by formula (A) and their pharmaceutically acceptable salts and esters, wherein R is an amino acid.

The present invention relates to a pharmaceutical composition for preventing or treating cartilage disease or inflammatory joint disease and a method for preparing a chondrospheroid having chondrocyte differentiation ability. The present invention provides a pharmaceutical composition comprising a stem cell-derived spheroid as an active ingredient for preventing or treating cartilage disease or inflammatory joint disease, and a method for preparing a chondrospheroid having chondrocyte differentiation ability, the method comprising the steps of: Inoculating stem cells into a three-dimensional (3D) cell culture vessel made of a plastic material; treating the stem cells inoculated into the 3D cell culture vessel with a chondrocyte differentiation-inducing factor; culturing the stem cells treated with the chondrocyte differentiation-inducing factor to form chondrospheroids; and separating the formed chondrospheroids.

The present invention provides a pharmaceutical composition for preventing or treating cartilage / bone / joint diseases, the pharmaceutical composition containing, as active ingredients, a substance that inhibits the signal transduction of semaphorin 4D-plexin B2, for example: a substance that inhibits the binding of plexin-B2 and semaphoring 4D; a substance that inhibits the binding of c-Met and semaphorin 4D; a substance that inhibits the binding of plexin B2 and Traf2; and a substance that inhibits the binding of plexin B2 and c-Met. In addition, the present invention provides a method for screening a drug for preventing or treating cartilage / bone / joint diseases, the method comprising a step for selecting a substance to be tested that inhibits the signal transduction of semaphorin 4D-plexin B2.

The invention provides a tendon-relaxing and blood-activating composition, a tendon-relaxing and blood-activating extract, a preparation and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The composition for relaxing the muscles and stimulating the blood circulation comprises gentiana macrophylla, speranskia tuberculata, cassia twig, eucommia ulmoides, rhizoma atractylodis, radix aconiti, myrrh, salvia miltiorrhiza, divaricate saposhnikovia root, the root of kudzu vine, safflower carthamus, the root of bidentate achyranthes, notopterygium root, rhizoma drynariae, fermented rheum officinale and fermented hiraute shiny bugleweed herb. The pharmaceutical composition can effectively relieve, treat and prevent joint diseases, and is good in stability and convenient to store for a long time.

The invention discloses a traditional Chinese medicine composition for treating joint diseases and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25 to 45 parts of radix angelicae pubescentis, 25 to 45 parts of cortex phellodendri, 20 to 40 parts of rhizoma smilacis glabrae, 20 to 40 parts of rhizoma dioscoreae septemlobae, 20 to 40 parts of rhizoma chuanxiong, 20 to 40 parts of semen coicis, 20 to 40 parts of radix cyathulae, 20 to 40 parts of herba artemisiae scopariae, 20 to 40 parts of herba lycopodii, 20 to 40 parts of rhizoma polygoni cuspidati, 20 to 40 parts of radix dipsaci, 20 to 40 parts of rhizoma atractylodis, 20 to 40 parts of semen plantaginis and 10 to 25 parts of liquorice root. The traditional Chinese medicine composition has a relatively good treatment effect on gout, rheumatic arthritis and rheumatoid arthritis, can treat both symptoms and root causes, and is relatively small in side effect and relatively small in harm to a human body.

This invention relates to a recombinant human secretory DDRGK1-Fc and its applications. Through experimental verification, the invention synthesizes recombinant human secretory DDRGK1-Fc, which has good bone-promoting function and is applied to the preparation of drugs for treating bone and joint-related diseases, promoting cartilage formation, and promoting intervertebral disc formation. This opens up new ideas for the treatment of bone and joint diseases and has obtained relatively solid scientific evidence.

The present invention provides a composition comprising an anionic lipid composition and a polycationic aggregating agent for use in the intra-articular treatment of a joint disease or disorder, such as osteoarthritis. In addition, a kit for preparing the composition and a novel composition comprising the anionic lipid composition and a polycationic aggregating agent are also provided.

The invention discloses a novel invisible appliance for treating temporomandibular joint disease pain, which relates to the field of medical instruments and comprises a rear tooth socket, an upper jaw invisible appliance and a lower jaw invisible appliance, the rear tooth socket is arranged at the rear ends of the invisible upper jaw appliance and the invisible lower jaw appliance, an upper jaw pad is arranged at the bottom end of the invisible upper jaw appliance, and a lower jaw pad is arranged at the top end of the invisible lower jaw appliance; canine tooth sleeves are arranged on the upper jaw invisible orthodontic appliance and the lower jaw invisible orthodontic appliance, a traction hook is arranged at one end of each canine tooth sleeve, and an elastic traction ring is arranged on the periphery of each traction hook; the posterior tooth interlocking structure and the anterior tooth vertical traction structure are integrated into the invisible orthodontic appliance, so that orthodontic treatment and temporomandibular joint disease pain treatment are integrated, the treatment period is shortened, and patient compliance is improved; the V-M interlocking structure accurately locks the lower jaw, the vertical traction realizes condylar process reduction, the pain is relieved from pathogenesis, the digital design can realize personalized adaptation, and the double stable curative effects of correction and pain treatment are ensured.

The application discloses a functional composition, a conditioner and a use for treating or preventing bone and joint diseases. The composition of the functional composition comprises a first active component and a second active component, wherein the first active component comprises elastin peptide 1-500 mu g / mL, haematococcus pluvialis 40-20 mu g / mL, phyllanthus emblica 8-4 mu g / mL and mussel 1-500 mu g / mL in terms of concentration in the functional composition; and the second active component comprises broccoli water extract and / or boric acid substances. The application realizes the synergistic improvement of glycosaminoglycan and osteocalcin levels by scientific compounding, plays a protective role on joint, cartilage and bone health, and has natural, safe, good biocompatibility and no obvious side effects, and provides a kind of drug or a replacement scheme for bone disease treatment and prevention.

The invention belongs to the technical field of biological medicine, and particularly relates to a preparation method and application of an amniotic fluid active complex. According to the method, inherent physical and chemical differences of different components in amniotic fluid are utilized, through a series of physical steps, the components are firstly and mildly grouped and enriched according to categories, and then the components are guided to be self-assembled again under controllable conditions to form a composite particle with a compact structure. The natural aggregation state of active ingredients in a living body before secretion or action is simulated, so that the multi-element active ingredients which naturally coexist and interact in amniotic fluid are efficiently captured and transferred as a complete functional unit, the natural ingredient spectrum is not damaged, and the original advanced structure and function are not lost. The invention provides application of an amniotic fluid active complex (RSC) in treating or preventing joint diseases or symptoms. The RSC has obvious effects in promoting cartilage matrix synthesis, inhibiting moderate and mild osteoarthritis and relieving pain.

The application provides a KOA-PT therapy-based exercise rehabilitation treatment instrument for periprosthetic joint disease, which comprises a base placed on the ground, a frame capable of stretching up and down and fixedly connected to the base at one end and arranged close to the end of a treatment leg of a patient, a swing arm capable of stretching up and down and arranged in a suspended manner and swing-connected to the stretching end of the frame close to the side of the treatment leg of the patient, a foot part in an L-shaped vertical section, used for placing the treatment leg of the patient and capable of sliding up and down along the axis of the swing arm, sliding left and right along the radial direction of the swing arm and rotating around the lower part of the swing arm, and a pedal arranged close to the side of the treatment leg of the patient, wherein the L-shaped upper part of the pedal is fixedly connected with a C-shaped clamp close to the side of the treatment leg of the patient. The application enables the patient to stand on the base with a non-treatment leg and swing the treatment leg, or enables the patient to lie on a bed arranged directly above the base and swing and bend the treatment leg.

The present application relates to the technical field of bone and joint diseases, and particularly relates to an artificial intelligence assisted diagnosis and treatment system for bone and joint diseases based on an internet hospital; comprising: an information management module; an intelligent diagnosis assistance module; a remote monitoring and rehabilitation guidance module; a disease risk prediction module; a doctor-patient interaction and health popularization module, the present application builds a comprehensive system covering information collection, data integration, image analysis, rehabilitation tracking and other functions, systematically manages the whole process information of patients from pre-consultation to rehabilitation period, effectively improves the continuity of diagnosis and treatment and the level of personalized service, uses deep learning, natural language processing, knowledge graph and other artificial intelligence technologies to automatically complete bone and joint image recognition, symptom analysis and rehabilitation plan making, greatly improves the efficiency and accuracy of doctor's diagnosis, and simultaneously realizes dynamic adjustment and fine guidance of the rehabilitation scheme.

Provided herein is a composition comprising a population of mesenchymal stem cell (MSC) aggregates, wherein the aggregates have a mean diameter between 30 to 250 microns and number of cells per aggregate between 100 to 500 MSCs. Also provided is a method of producing said composition, and a method of obtaining conditioned medium from said aggregates. Both the composition comprising the aggregates, and the conditioned medium may be used to treat diseases, disorders, conditions or injuries such as age-related disorders, chronic and acute inflammatory conditions (including arthritis), degenerative joint diseases (including osteoarthritis), joint injury, chronic and acute respiratory diseases, musculoskeletal conditions, neurodegenerative diseases and / or brain injury.

Provided herein are joint deliverable oligonucleotide modulators and the use thereof in the treatment of joint diseases, such as rheumatoid arthritis (RA). The intra-articular (IA) deliverable oligonucleotide agents comprise: a double-stranded oligonucleotide capable of modulating the expression of a selected gene associated to a joint disease, and one or more delivery moieties conjugating to the double-stranded oligonucleotide for delivery of the oligonucleotide to cells in the joint. Also provided are products comprising the same, methods for delivering the same to cells in the joint, and methods for the treatment of joint diseases using the same.

A glucosamine derivative-containing composition comprising, based on the total weight of the composition, 55-70 wt%, preferably 55-65 wt%, more preferably 60-65 wt% of a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. The present invention further relates to a use of the glucosamine derivative-containing composition in the preparation of a drug for preventing or treating bone or joint diseases of subjects in need.

The present invention relates to the field of medicine and more particularly to pharmaceutical agents for the treatment of joint diseases. A medicament for treating joint diseases comprises an effective amount of sodium chondroitin sulfate and at least one adjuvant or carrier, and further contains iron in a relative amount of 1 mg / kg to 40 mg / kg based on the mass of the sodium chondroitin sulfate.

1. The name of the design product: LED infrared physiotherapy lamp (vertical type). 2. The use of the design product: physiotherapy instrument for assisting in the treatment of joint diseases of the user, relieving pain, reducing inflammation, promoting wound healing, and promoting skin damage recovery. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses a functional composition for treating or preventing bone and joint diseases, a conditioner and application. The functional composition comprises a first active component and a second active component, and according to the concentration of the functional composition, the first active component comprises 1 [mu] g / mL-500 [mu] g / mL of elastin peptide, 40 ng / mL-20 [mu] g / mL of haematococcus pluvialis, 8 ng / mL-4 [mu] g / mL of emblic leafflower fruit and 1 [mu] g / mL-500 [mu] g / mL of mussel; the second active component comprises a broccoli aqueous extract and / or boric acid substances. Through scientific compatibility, all the components synergistically improve the levels of glycosamine poly and osteocalcin, the health of joints, cartilages and bones is protected, the components are natural in source, safe, good in biocompatibility and free of obvious side effects, and a medicine or an alternative scheme thereof is provided for treatment and prevention of bone diseases.