111 results about "Animal subject" patented technology

Automated systems and methods are presented for determining the physiological response of human or suitable animal subjects to physical exertion. The methods and systems can include monitoring sensors that capture the motion of the subject along with corresponding physiological data, and can track such motion for the duration of a period of physical exertion. The system is able to acquire an initial stream of physiological data from the subject during a range of physical exertion activities that are representative of the events intended to be monitored with the proposed method and system, enabling a corresponding dynamic physiological response model to be created. The motion tracking system and physiological response model can then be used to predict the physiological response to physical exertion events under a prescribed framework, including applications during real-time event monitoring.

A hemostasis valve capable of controlling a flow of fluid in a tube or catheter to and from a vasculature of a human patient or animal subject. An exemplary embodiment of the hemostasis valve includes a valve member having a lumen with a proximal end and a distal end for receiving flexible tubing or a catheter. The hemostasis valve includes one or more constricting wires that are tensioned by connections to valve member components. The hemostasis valve includes one or more force receiving contact surfaces connected to at least one of the one or more constricting wires configured to cause the contracting wires to constrict the flexible tube or catheter passing therethrough, when the one or more force receiving contact surfaces are in flow restricting state. The force receiving contact surfaces cause the constricting wires to release the flexible tube or catheter passing therethrough, when the one or more force receiving contact surfaces are in a not is a flow restricting state.

A prosthesis or orthosis comprising a hinge joint system for functionally assisting, enhancing, and / or replacing a hinge joint system of a human or animal subject, said hinge joint system comprising: a first member (10); a second member (20) being pivotally attached to the first member; a linkage element or an actuator (30) connected to the first member; a flexible member (40) connecting the second member and the linkage element or the actuator; at least one contact stiffening element (50) configured for being or entering in contact with the flexible member and for providing a lever action along a length of the flexible member.

The invention provides a physical manipulation apparatus that is engageable with a skin surface of a human or animal subject. The apparatus may include a skin-engageable pad configured to conform to the morphology of a physical manipulation member such as a digit of a human therapist or a stylus tip of a chiropractic adjustment instrument. The skin-engageable pad may include a friction-inducing component in the form of a biomimetic dry adhesive. The apparatus may include a digit cover (110, 120, 130) configured at least partially to cover a human digit. Instead, the apparatus may be configured as a skin patch having two release liners superimposed, respectively, on opposite sides of the skin-engageable pad. The skin patch may include indicia arranged to indicate a required orientation of the skin patch relative to a targeted anatomical feature such as a spinal segment, or a required direction of movement of the manipulation member.

A method of operating a counterpulsation device (CPD) in a human or animal subject is disclosed, the method including: receiving a heart beat signal indicative of the heart beat of the subject; providing counterpulsation therapy by controlling the pressure supplied to a CPD drive line in pneumatic communication with the CPD to cause the CPD to alternately fill with blood and eject blood with a timing that is determined at least in part based on the heart beat signal; while providing counterpulsation therapy, receiving a CPD drive line pressure signal indicative of the pressure in the CPD drive line; and adjusting the pressure supplied to the drive line based at least in part on the drive line pressure signal.

A pouch 200 for transmucosal delivery of a neuroactive, psychoactive and / or bioactive compound in the mouth of a human or animal subject, comprises a liquid permeable cover 202 and a plurality of dissolvable lozenges 204, 206, 208 contained within the cover. Each of the plurality of lozenges comprises a matrix material and a neuroactive, psychoactive and / or bioactive compound suspended within the matrix material. A first lozenge of the plurality of lozenges comprises a first matrix material and a first concentration of a neuroactive, psychoactive and / or bioactive compound suspended in the first matrix for delivering a first dosage profile to the human or animal subject. A second lozenge of the plurality of lozenges comprises a second matrix material and a second concentration of the and / or a further neuroactive, psychoactive and / or bioactive compound suspended in the second matrix for delivering a second dosage profile to the human or animal subject. The pouch may also include an inner permeable cover (304, fig 3), which includes a plurality of inner dissolvable lozenges (308, fig 3). A first lozenge may comprise a plurality of layers (402, 404, fig 4), for delivering a different concentration and / or a further neuroactive, psychoactive and / or bioactive compound.

A biocompatible medical device can be at least partially implantable into a living human or animal subject to provide active treatment of biofilm that can occur use within the subject. The medical device can include a catheter, including an interior conduit capable of permitting fluid flow. A heating device can be located on a portion of the catheter to be located within the subject, the heating device including at least a pair of electrodes having a variable spacing therebetween, the variable spacing specified to allow heat to be generated using a time-varying electromagnetic input signal providing a variable frequency to control a variable location along the electrodes at which heat is generated, such as can provide a virtual matrix of local heat sources.

An implantable device for interfacing with a nerve of a human or animal subject, the device comprising: a transducer comprising a sensing array having three or more electrodes arranged along an axis; an actuator configured to output a stimulus; a controller in electrical communication with the electrodes and the actuator, wherein the controller is configured to: receive a plurality of signals from the sensing array; process the signals using velocity selective recording (VSR) to determine a current electrophysiological representation of the subject, wherein VSR uses a plurality of measurement delays to provide a first plurality of velocity filtered signals representative of velocity data of a current signal travelling through the nerve; compare the current electrophysiological representation to a baseline electrophysiological representation, wherein the baseline electrophysiological representation comprises a second plurality of velocity filtered signals representative of velocity data of a baseline signal travelling through the nerve; based on the comparison, identify an electrophysiological biomarker; and control the actuator in the transducer to output said stimulus.

This invention discloses a rotation-consistent target perception high-frequency wildlife re-identification method, relating to the field of board processing technology. This invention performs rotational modeling only on the target high-frequency tokens or their corresponding two-dimensional feature maps obtained through target-frequency joint selection. This allows rotation robustness learning to focus on identity-related details such as texture, spots, stripes, and contours of the animal subject. This mechanism reduces the risk of rotational enhancement of background high-frequency noise. The target-frequency joint selection mechanism suppresses high-frequency noise from natural backgrounds such as grass, leaves, water ripples, and rocks, improving the model's ability to focus on the animal subject's discrimination region. The target-frequency joint selection mechanism identifies image patches that are truly relevant to the animal subject and have significant high-frequency details, and establishes feature-level rotation and consistency constraints only on the target high-frequency tokens, thereby simultaneously suppressing background high-frequency noise and enhancing robustness against directional changes.

In mass spectrometry, a deuterium-resolved mass spectrum of a gas sample that determines the composition of volatile metabolites excreted by a human or animal subject after ingestion of deuterated water. The deuterium-resolved mass spectrum is used to determine the presence or amount of at least one deuterated metabolite. In addition, a corresponding mass spectrometry system is also disclosed.

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

In one embodiment, a method comprising: (a) receiving a set of physiological data associated with at least one health condition of an animal subject; (b) receiving a set of environmental data associated with one or more environment conditions to which the subject is or has been exposed; (c) determining a set of operating parameters for at least one environmental device based at least partially on at least a portion of the set of physiological data and at least a portion of the set of environmental data; and (d) transmitting the set of operating parameters to the at least one environmental device to at least partially control at least one controlled environmental condition to which the subject is exposed to thereby at partially control the at least one health condition.

Provided herein are systems and methods for animal health assessment, surveillance, and enhancement. For example, provided here are systems, devices, and processes that collect and analyze, in an efficient and high-throughput manner, biological information, environmental information, and demographic information about animal subjects to detect, identify, predict, and / or surveil adverse-health-causative or-associated agents, such as pathogens, and to select and identify suitable interventions.

The present invention relates to a composition for reducing appetite and / or promoting weight loss, the composition comprising, in a first compartment, a first composition comprising a hydrophilic polymer selected from polysaccharides, their derivatives and mixtures, a crosslinking compound, a foaming agent and a foam stabilizing agent, and, in a second compartment, separate from the first compartment, a second composition comprising citric acid. The invention also relates to methods of administering the composition according to the invention to a human or animal subject.

The present invention relates to the application of toxicogenomics methods to the detection and / or prediction of histopathological abnormalities in human or animal subjects based on clinical pathology data. It has been observed that reliable results can be obtained even in the absence of image data. A computer-implemented method for predicting the presence of a histopathological abnormality in an organ of a human or animal subject based on clinical pathology data comprises receiving clinical pathology data obtained from the human or animal subject, applying an analytical model to the clinical pathology data, the analytical model being configured to output a result indicative of the likelihood of the presence of the histopathological abnormality in the organ of the human or animal subject, and outputting the result.

An insufflator is operable in a set-up mode and in a normal insufflating run mode. In the set-up mode, a pressure / volume relationship between cavity pressure and cavity volume of the cavity of a subject is determined. A minimum safe working pressure value and a maximum safe working pressure value of a working pressure range for the cavity to be insufflated is determined from the pressure / volume relationship as a pressure value just above a lower point of inflection and an upper point of inflection of the pressure / volume relationship, respectively. In the normal insufflating run mode a working pressure value is selected from the range of working pressure values and the insufflator insufflates the cavity to the selected working pressure value. Also disclosed is an insufflating system comprising an insufflator operable in a set-up mode and in a normal insufflating run mode. A controller located remotely relative to the insufflator remotely controls the insufflator to operate in the set-up mode and / or the normal insufflating run mode.

A pouch for controlling release of a neuroactive and / or psychoactive compound in the mouth of a human or animal subject, the pouch comprising: a liquid permeable cover; and a plurality of dissolvable lozenges contained within the cover, each of the plurality of lozenges comprising: a matrix material forming a shape of the lozenge, said shape having a surface area, the matrix material being dissolvable in the mouth of the human or animal subject at a dissolution rate; and a neuroactive and / or psychoactive compound suspended within the matrix material at a compound concentration, wherein each lozenge has a known release rate of the neuroactive and / or psychoactive compound in the mouth of the user that is determined based on the surface area, the dissolution rate and the compound concentration and is sustained within upper and lower release rate limits over a release time period.

In one aspect, the disclosure relates to a method for neuromodulation in a target, wherein the target can be an isolated plurality of cells, an isolated organ, or an animal subject In an aspect, the method includes at least the step of delivering X-ray radiation to one or more neurons in the target, wherein the one or more neurons express dTRPA1(A)10b, and wherein the X-ray radiation generates H2O2 via radiolysis of water. In a further aspect, the H2O2 can increase intracellular calcium ions which can, in turn, stimulate the release of neurotransmitters. Also disclosed are treatments of diseases, disorders, and symptoms thereof using the disclosed method.

The present invention relates to Lactobacillus paracasei HH20 MXS_B2_71_3 strain DSM 34860 and / or Lactobacillus rhamnosus HH03 OB-Lb-0655 strain DSM 34859, in the form of viable cells and / or non-viable cells and / or cell fragments and / or as fermentation broth, or combinations thereof, for use as a medicament, preferably for use as a medicament in one or more human and / or animal subject; as well as oral care compositions, methods and kits comprising said species.

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

A method for predicting abnormal eye convergence in a human or animal subject may involve tracking eye movement of at least one eye of the subject to generate eye tracking data for the subject and using the eye tracking data to predict whether the subject has abnormal eye convergence. A method for diagnosing a brain injury in a human or animal subject may involve tracking eye movement of at least one eye of the subject to generate eye tracking data for the subject, using the eye tracking data to predict whether the subject has abnormal eye convergence, and predicting whether a brain injury has occurred in the subject, based on the prediction of whether the subject has abnormal eye convergence.

The processing subsystem communicates with brain regions of an animal subject that are responsible for forming concepts, without sensory input. The processing subsystem receives brain signals representing concepts formed by these brain regions, without sensory input. The processing subsystem processes the received brain signals to convert the concepts into computer-readable data that represents their tangible form. The processing subsystem identifies data records associated with one or more data elements of the computer-readable data, and also associated with real-world objects associated with the concepts.

Testing methods for evaluating visual and neurological functions of a human or animal subject that involve conscious perception. The tests include a training phase, a practice phase, and a visual rivalry phase for detecting binocular rivalry or multistate competition. The design of the testing methods offers simple, rapidly administered, nonverbal visual testing with high time resolution and access to changing conscious perceptual states of the test subject. The methods also make possible the collection of a large amount of data in a short time for analysis of the subjects visual function and brain function, and can be used in the diagnosis of many medical conditions.

Devices, systems, and methods for measuring the diameter of an airway in a human or animal subject are disclosed. The device comprises a flexible catheter body having a proximal end and a distal end. Flexible sizing elements are disposed along and extend approximately orthogonally from the catheter body. The sizing elements have different heights from one another and are configured to fit through the working channel of a bronchoscope. Devices, systems, and methods for redirecting airflow through a lung airway are also disclosed. The method comprises introducing into the airway a catheter comprising a distal end, a proximal end and an elongated portion therebetween, wherein the distal end comprises an airway closing mechanism, and wherein the proximal end comprises an actuator to actuate the airway closing mechanism; and actuating the airway closing mechanism to at least partially close the airway.

Described herein are UV-resistant or UV-protective biological devices and extracts produced therefrom. The biological devices include microbial cells transformed with a DNA construct containing genes for producing UV-resistant proteins such as, for example, hexokinase, heat shock proteins, alcohol dehydrogenase, transferrin, flavonol synthase, zinc oxidase, and iron oxidase. Methods for producing and using the devices are also described herein. Finally, compositions and methods for using the devices and extracts to reduce or prevent UV-induced damage or exposure to materials, items, plants, and human and animal subjects are described herein.

Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. The method may include the steps of withdrawing fluid comprising CSF, filtering the volume into permeate and retentate by passing the fluid through a tangential flow filter, and returning the permeate to the subject. During operation of the system, various parameters may be modified, such as flow rate.

To provide peptide compositions and methods for inhibiting neovascularization or development of pathogenic or aberrant blood vessels in human or other animal subjects.SOLUTION: Provided herein is a composition comprising a peptide consisting of an amino acid sequence of Gly-Arg-Gly-Cys-Thr-Pro. The composition is administered to a human or animal subject for inhibiting neovascularization or development of pathogenic or aberrant blood vessel in a therapeutically effective amount. The composition is also administered to the eye of a subject with neovascularization or development of pathogenic or aberrant blood vessels to treat the eye disease or disorder of the subject.SELECTED DRAWING: Figure 5

A method for using saliva to measure at least one substance or physiological parameter of a human or animal subject may involve inserting a first end of a sensor into a handheld saliva testing device. The method may also involve receiving saliva from the subject on a second end of the sensor, moving the saliva from the second end of the sensor to the first end, and processing the saliva with the handheld saliva testing device to provide initial saliva data related to the at least one substance or physiological parameter of the subject. In some embodiments, the sensor remains inserted in the handheld device while the subject deposits saliva on the opposite, free end of the sensor.

A system for processing the response of a human or animal subject to sensory stimuli is disclosed. The system includes: means for emitting these stimuli towards the subject; means for detecting the response of the subject to these stimuli; means for subjecting the subject to instructions for responding to these stimuli in response to instructions previously taught to the subject, the instructions having increasing or decreasing complexity according to at least three difficulty levels; means for measuring the reaction time to simple stimuli corresponding to a first difficulty level and means for measuring the reaction time to stimuli corresponding to a second difficulty level associated with a choice regarding categorization; and means for measuring the reaction time associated with a third difficulty level, the third difficulty level including a task in which the subject must perform two categorizations of the same stimulus simultaneously.