Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

52 results about "Gingival tissue" patented technology

Gingival tissue is the area around the root of the tooth that helps keep the tooth in place. Depending on where the gingival tissue is in relation to the tooth, it may be called one of two names. The gum tissue that is attached to the alveolar bone is called free gingiva.

Monitoring method for analyzing oral implant health based on using images

The invention relates to the technical field of oral implantation monitoring, and discloses a monitoring method for analyzing oral implantation health based on using images. The method comprises the following steps: acquiring an optical image data sequence of an oral implanting region by adopting optical scanning equipment, constructing a three-dimensional oral tissue model containing gingival contour features and an implant position, and identifying actual position distribution information of an implant in gingival tissue; and extracting an implant health index set comprising an implant marginal definition value, a surrounding gingival red and swollen area proportion and a gingival atrophy degree value. When any index exceeds a preset health threshold interval, abnormal early warning information is generated, scanning parameters are dynamically adjusted, and images are collected again for iterative monitoring. According to the method, dynamic and accurate monitoring of oral implant health can be realized, health abnormity of the implant can be found in time, and support is provided for long-term health maintenance of the implant.
Owner:HOSPITAL OF STOMATOLOGY XIAN JIAOTONG UNIVERSITY

Oral care apparatus

Proposed are schemes, solutions, concepts, designs, methods and systems pertaining to aiding and / or improving oral care apparatus having cleaning elements that are adapted, in use, to engage dental tissue of the user. Embodiments propose that, based on light reflected from a surface of the oral cavity during use, an indication of positioning with respect to a tooth surface or gum tissue of the user may be determined. That is, it may be determined whether a cleaning element is positioned at a tooth surface or gum tissue of the user by analyzing light reflected from a surface of the oral cavity.
Owner:KONINKLIJKE PHILIPS NV

Apparatus and methods for treating teeth

An apparatus for treating a tooth or gum tissue is disclosed. The apparatus can include a tooth cap for supporting a treatment device during a treatment procedure. The tooth cap can comprise a platform to support the treatment device. The platform can include an access port to provide a portion of the treatment device with access to a treatment region of the tooth or gum tissue. The tooth cap can also include a wall coupled with and angled relative to the platform, the wall configured to be attached to the tooth or gum tissue during treatment.
Owner:SONENDO INC

Intraoral 3D scanning with automatic charting

A method for intraoral imaging generates one or more output imaging signals from an intraoral probe and acquires multimodal image content from intraoral surface locations according to tissue response from the one or more imaging signals and associates spatial coordinates to the acquired multimodal image content. A surface contour of the patient dentition is generated by stitching the acquired multimodal image content and preserving the association of spatial coordinates with the stitched multimodal image content. Tooth outlines for one or more teeth are generated from the generated surface contour and the generated outlines arranged as a dental chart representing a spatial ordering of the one or more teeth and of supporting gum tissue adjacent to the teeth. The dental chart is populated by analyzing the acquired multimodal image content and associating the analysis to positions on the dental chart according to the preserved association of spatial coordinates and is displayed.
Owner:DENTAL IMAGING TECHNOLOGIES CORP

Dental crown fixing abutment structure convenient to disassemble

The utility model discloses a dental crown fixing abutment structure convenient to disassemble, which relates to the technical field of medical equipment and comprises an implant retention screw, an abutment fixing seat is arranged on the outer side of the top of the implant retention screw, an abutment is butted on the abutment fixing seat, and a locking screw is arranged in the abutment. According to the dental crown fixing abutment structure convenient to disassemble, the abutment and the dental crown can be assembled and disassembled through fixing and disassembling of the locking screws, and the situation that the abutment is repeatedly taken and worn, mechanical stimulation is caused to gingival tissue when the abutment is taken off and worn, and local inflammatory response is induced is effectively avoided; multiple times of confirmation of in-position precision in the repeated wearing and taking-off process of the abutment are avoided, and the reworking frequency is reduced.
Owner:SHAANXI QIMEIRAN MEDICAL TECHNOLOGY CO LTD

Fiber membrane for guiding periodontal tissue regeneration

ActiveCN224113056USurgeryOsteoblast adhesionGingival tissue
The utility model provides a fibrous membrane for guiding periodontal tissue regeneration, and relates to the technical field of medical instruments. Preparing a PLGA double-layer fiber membrane loaded with drug-loaded sodium hyaluronate particles through the cooperative work of electrostatic spinning and electrostatic spraying; the sodium hyaluronate particles can greatly improve the loading rate of hydrophilic anti-inflammatory antibacterial and bone regeneration promoting medicines; a PLGA compact layer in the PLGA double-layer fiber membrane is loaded with first sodium hyaluronate particles loaded with anti-inflammatory and antibacterial drugs, and when the first sodium hyaluronate particles make contact with gingival tissue, cell adhesion and permeation can be hindered, and the anti-inflammatory and antibacterial effects can be achieved; a PLGA loose layer in the PLGA double-layer fiber membrane carries second sodium hyaluronate particles loaded with a bone regeneration promoting medicine, and the second sodium hyaluronate particles can promote osteoblast adhesion and facilitate dentale regeneration when making contact with bone tissue.
Owner:HANGZHOU GUILING MEDICAL INSTR CO LTD

Multi-angle film gingival scalpel

This utility model discloses a multi-angle gingival scalpel, relating to the field of scalpel technology. It includes a handle, a base, a blade, and an angle adjustment mechanism. One end of the handle is connected to the base via the angle adjustment mechanism, and the blade is detachably mounted on the base. The angle adjustment mechanism includes a knob, a limiting block, a limiting plate, a ball, an elastic element, and a connecting rod. The angle adjustment mechanism allows for flexible adjustment of the base angle, which in turn adjusts the blade angle. This enables the surgeon to precisely position and operate the blade according to the patient's oral condition, ensuring that cutting and trimming operations are accurately applied to the target gingival tissue. This improves surgical precision and reduces surgical errors caused by operational deviations.
Owner:上海市静安区牙病防治所

Method for obtaining porcelain glaze material with antibacterial properties and increased mechanical, aesthetic and microbiological properties used in dental restoration

The invention relates to obtaining an Ag / Zn-containing zeolite glaze that is applied to the outer surface of a ceramic (Ips™ e.max press), which is widely preferred today due to its aesthetic properties and used both as a dental restoration material and as a veneering / crowning material, to impart antibacterial properties to the porcelain glaze (coating / glaze) material and improve its mechanical and aesthetic features, thereby protecting the tooth and gingival tissues.
Owner:SÜLEYMAN DEMİREL ÜNİVERSİTESİ İDARİ VE MALİ İŞLER DAİRE BAŞKANLIĞI GENEL SEKRETERLİK

Toothbrush head and toothbrush

ActiveCN224474175UBristleTooth enamel
The toothbrush head of the present disclosure comprises two bristle planting pieces which are arranged in sequence along the extension direction of the toothbrush handle, each of the bristle planting pieces comprises tooth surface cleaning bristle planting holes, gum cleaning bristle planting holes and interdental cleaning bristle planting holes, the gum cleaning bristle planting holes are arranged at the left and right ends of the tooth surface cleaning bristle planting holes, and the interdental cleaning bristle planting holes are arranged at the upper end or the lower end of the tooth surface cleaning bristle planting holes.
Owner:SHENZHEN SOOCAS TECH CO LTD

Antibacterial oral care toothpaste based on active ingredients of melia azedarach

PendingCN122376504ABiotechnologyMouth care
The present application relates to toothpaste technical field, specifically, it relates to the bacteriostatic oral care toothpaste based on active ingredient of mountain ardisia. It includes sorbitol, hydrated silicon stone, deionized water, polyethylene glycol-8, sodium lauryl sulfate, essence, polyquaternium-22, cellulose glue, sodium saccharin, hydroxypropyl guar gum, sodium methyl hydroxybenzoate and mountain ardisia extract;The bacteriostatic oral care toothpaste based on active ingredient of mountain ardisia, by introducing the mountain ardisia extract with specific chemical composition into the formula system, effectively solve the problem that the existing oral care product is not strong in specificity to periodontal pathogenic bacteria, and the bacteriostatic spectrum is relatively single;The mutual synergistic effect relationship exists between the extract, not only broaden the inhibition spectrum of periodontal pathogenic microorganism, also can reduce the oxidative stress and inflammatory response of gingival tissue, thereby maintaining oral cleaning, improve the comprehensive performance of oral care product and the mildness of use.
Owner:JIANGXI ACAD OF FORESTRY +1

Oral care device with sensing functionality

An oral care system for sensing blood in an oral cavity and in gum tissue. The sensing is performed magnetically using a magnetic field source (16) and magnetic sensing arrangement (18) incorporated into a cleaning or treatment portion of an oral care device (e.g. a brush head of a toothbrush or mouthpiece part of a brushing mouthpiece device). The field source generates (16) a reference field and the sensing arrangement (18) is arranged to sense the field strength of the reference field at one or more spatial points. Since blood is magnetic, when brought into the reference field, it magnetically interacts with the field, which may alter field strength, field shape, or flux distribution. This enables presence of blood to be detected. It also allows for detecting specific oral features or disease states associated with presence of blood or abnormal amounts or concentrations of blood. For example, this can be based on application of detection criteria which relate to one or more properties of the sensed field.
Owner:KONINKLIJKE PHILIPS NV

A water pressure intelligent adaptation method and system for a water flosser

This invention relates to the field of biosensor technology, and discloses a method and system for intelligent water pressure adaptation of a water flosser based on integrated sensing. The method includes: determining the cleaning area of ​​the target oral cavity for the water flosser; analyzing the health of the cleaning area based on gingival tissue state data, and analyzing the cleaning needs of the cleaning area based on oral pressure data; combining health and cleaning needs, and analyzing the initial water pressure value of the cleaning area using a preset area-state-water pressure mapping model; collecting the subconscious physiological reaction signals of the oral cavity user corresponding to the initial water pressure value, and analyzing the comfort coefficient of the oral cavity user based on the subconscious physiological reaction signals; optimizing the initial water pressure value based on the comfort coefficient to obtain a target water pressure value, and performing intelligent water pressure adaptation of the water flosser to the target oral cavity based on the target water pressure value. This invention can improve the cleaning effect for oral cavity users.
Owner:深圳科士洁科技有限公司

Three-dimensional biomaterial loaded with active complement fragments for dental and / or other tissue regeneration

UndeterminedES3073355T3Gingival tissueBone tissue
The present invention relates to a three-dimensional biomaterial comprising particles that encapsulate at least one complementary active fragment dispersed therein. The invention also relates to a process for manufacturing said biomaterial. This biomaterial is useful for tissue regeneration, especially of dental pulp, dentin, periodontal and gingival tissues, as well as bone tissues.
Owner:UNIVERSITÉ DAIX MARSEILLE (33 33) +1

Antibacterial toothpaste and preparation method thereof

The invention discloses antibacterial toothpaste and a preparation method thereof.The antibacterial toothpaste is prepared from hyaluronic acid, calcium carbonate, kaolin, a ganoderma lucidum extract, an aromatic, glycerin, sodium chloride, hydroxyethyl cellulose, lauryl sodium sulfate and deionized water, a proper amount of kaolin is added, the kaolin has a certain medicinal value, and the antibacterial toothpaste is good in antibacterial effect. The mouthwash has the effect of eliminating edema, that is, redundant moisture under gingival tissues of a human body can be removed, the kaolin acts on gingival wounds to achieve the effects of disinfection and sterilization, and has the effect of promoting repair of oral wounds, and the kaolin can adsorb pathogens such as bacteria and viruses attached to gingival mucosa, so that after gargling, the gingival mucosa does not have toxic or side effect. According to the present invention, the white clay is added, such that bacteria, viruses and other pathogens can be prevented from continuously harming oral health, the physical therapy effect of relieving and improving human oral diseases can be provided, and the white clay obtained by screening with the 500-700 mesh sieve has characteristics of good dispersion and good adsorption.
Owner:LEFT POINT HEALTH IND (SHENZHEN) CO LTD

Streptococcus salivarius CCFM1512, which metabolizes a product that inhibits excessive inflammatory response to relieve periodontitis

The application discloses a Streptococcus salivarius CCFM1512 which can inhibit excessive inflammatory response and relieve periodontitis, and belongs to the technical field of microorganisms. The fermentation supernatant of the Streptococcus salivarius provided by the application can relieve inflammation of human gingival fibroblasts induced by Porphyromonas gingivalis lipopolysaccharide in vitro, and can significantly reduce the expression of inflammatory factors such as IL-1beta, IL-6 and IL-17A in gingival tissues, regulate the M1 / M2 polarization balance of macrophages and restore the expression level of DEL-1, so as to relieve alveolar bone absorption of rats. The Streptococcus salivarius has a great application prospect in the aspects of regulating oral inflammatory response and preparing products for relieving periodontitis.
Owner:JIANGNAN UNIV

Unilateral alveolar split newborn maxilla orthopedic device

ActiveCN223930237UOthrodonticsGingival tissueAlveolar process
The unilateral alveolar split newborn maxilla orthopedic device comprises a palate plate and a retention stabilizing accessory, buccal side stretching accessories are connected to the outer portions of the left side edge and the right side edge of the palate plate, the material of the buccal side stretching accessories is softer than that of the palate plate, and the buccal side stretching accessories and the palate plate are of an integrated structure; the cheek side stretching accessory upwards protrudes out of the outer parts of the left and right side edges of the palate plate. The cheek side distraction accessory can generate an outward distraction effect on gingival tissues at the maxillary vestibular sulcus part, promote formation of new bones at the cheek side of maxillary alveolar bones, realize accurate quantitative controllable movement of alveolar bone sections, particularly effectively increase the transverse width, improve the comfort of the distraction effect due to the design of the edge buffer soft lining, and improve the safety of the distraction of the maxillary alveolar bones. The treatment effect is improved.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Method for generating target tooth arrangement, and electronic device

PCT designated stageWO2026065859A1OthrodonticsGingival tissueThree-dimensional space
Provided are a method for generating a target tooth arrangement and an electronic device. The method comprises: acquiring an initial tooth arrangement to be orthodontically treated and status of gingival tissue, thereby generating a three-dimensional digital dental jaw model corresponding to the initial tooth arrangement (101); on the basis of the three-dimensional digital dental jaw model (102), determining a WALA ridge-based spatial orthodontic reference curve; and on the basis of the spatial orthodontic reference curve, adjusting the pose of each tooth in the three-dimensional space in the three-dimensional digital dental jaw model to generate a target three-dimensional digital dental jaw model (103), adjusting the center of resistance of the tooth to be at the same height with the corresponding position on the spatial orthodontic reference curve, and adjusting the horizontal distance between the FA point of the tooth and the corresponding position on the spatial orthodontic reference curve to be within a preset range. The accuracy of acquiring a target tooth arrangement can be improved, so as to achieve a target tooth arrangement that better meets the oral physiological conditions of a patient.
Owner:SHANGHAI SMARTEE DENTI TECH CO LTD

Artificial tooth life cycle management system based on patient individualized information

The invention discloses an artificial tooth life cycle management system based on patient individualized information, and relates to the technical field of oral rehabilitation. The artificial tooth life cycle management system comprises an interface state monitoring module, an integrated electrical impedance signal acquisition unit, a state parameter calculation unit and an abnormal mark identification unit; high-precision real-time sensing of the physiological state of a contact interface of the false tooth edge and the gingiva can be achieved, a complex impedance sequence is obtained through an alternating micro-current injection and voltage response synchronous acquisition method, precise modeling of the electrical characteristics of gingival tissue is achieved in combination with the wearing state and time position data, resistance and reactance components can be distinguished, and the accuracy of the gingival tissue electrical characteristics is improved. Therefore, key physiological indexes such as gingival wettability, inflammatory response and an interface adhesion coefficient are accurately calculated, dynamic fluctuation analysis is further performed on the state parameters, biological abnormal events such as interface dryness, adhesion reduction or inflammation aggravation are found in time, automatic marking and data uploading are performed, and an accurate intervention basis is provided for doctors.
Owner:GUANGDONG WEILIMING TECH CO LTD

Gingival retractor

ActiveCN310071758SGingival tissuePeriosteum
1. Name of the product in this design: Gingival retractor. 2. Purpose of this design: To retract the gingival tissue or periosteum during oral cavity repair. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.
Owner:PUER PEOPLES HOSPITAL

Drug-loaded guided periodontal tissue regeneration membrane and preparation and application thereof

The application discloses a drug-loaded guided periodontal tissue regeneration membrane and a preparation and application thereof. The drug-loaded guided periodontal tissue regeneration membrane comprises a soluble composite matrix material and nano drugs loaded in the soluble composite matrix material. The application is based on the principle and manufacturing concept of periodontal GTR, conceives to design the interface implant into a structure with gradient change of components and structure, promotes bone growth, prevents bacterial infiltration and growth of gum tissue to the tissue defect area below, makes the characteristics of the membrane more and more tend to be "ideal", satisfies the local functional requirements, improves the multi-aspect performance of the membrane, and realizes more excellent tissue regeneration.
Owner:GUANGDONG PHARMA UNIV +1

Oral composition

To provide an oral composition usable for applications including tissue repair of gingiva.SOLUTION: An oral composition for application to the oral cavity including gingiva is prepared that comprises (A) 0.35 to 0.55 mass% of an allantoin and (B) 0.3 to 0.45 mass% of a glycyrrhetinic acid. Furthermore, a collagen production promoter is prepared that comprises an allantoin and a glycyrrhetinic acid.SELECTED DRAWING: None
Owner:ROHTO PHARM CO LTD

Implant abutment

ActiveCN224070616UDental implantsGingival tissueMechanical lesion
The utility model discloses an implant abutment which comprises an abutment main body used for being connected with an artificial dental crown, the implant main body is used for being connected with a gum, the implant main body is installed at the bottom end of the abutment main body, a clamping block used for connecting the implant main body and the abutment main body is arranged at the bottom end of the abutment main body, the clamping block is embedded into the inner wall of a clamping groove, the clamping groove is formed in the inner wall of an installation groove, the installation groove is formed in the top end of the implant main body, and the implant main body is connected with the abutment main body. The clamping blocks are uniformly distributed at the bottom end of the abutment main body in a circumferential array; the clamping blocks are installed on the inner walls of the sliding grooves in a sliding mode, and the sliding grooves are formed in the bottom end of the abutment body. The dental implant has the beneficial effects that the risk of mechanical injury to gingival tissues around the implant is reduced by changing the connection mode of the implant main body and the abutment main body, and the operation difficulty of medical personnel is reduced.
Owner:SHANGHAI CHUANGSHIJI MEDICAL TECHNOLOGY CO LTD

Gingival tissue hemodynamic spectroscopic index construction system based on near-infrared spectroscopy

The application discloses a kind of gingival tissue hemodynamics spectral index construction systems based on near infrared spectroscopy, it is characterized in that, including visible near infrared spectrometer and data processing unit;Wherein, the visible near infrared spectrometer is used to collect the spectral data of each target site around the tooth to be detected;The data processing unit is used to normalize the spectral curve in each spectral data collected to consistent measurement background, determine the spectral absorption characteristics of gingival tissue oxyhemoglobin and deoxyhemoglobin is extracted;Then based on the spectral absorption characteristics obtained, gingival tissue hemodynamics index is calculated.The gingival tissue hemodynamics spectral index obtained based on the application can assist in quickly, accurately, non-invasively and cost-effectively completing periodontal tissue inflammation detection, and provides accurate and effective assistance for the clinical diagnosis of periodontitis.
Owner:PEKING UNIV SCHOOL OF STOMATOLOGY

Temporary dental prosthesis for use in developing final dental prosthesis

ActiveUSRE50859E1Dental implantsImpression capsGingival tissuePermanent prosthesis
A method of manufacturing a permanent prosthesis for attachment to a dental implant installed in a mouth of a patient includes scanning a patient specific temporary prosthesis (PSTP) to obtain scan data. The PSTP is attached to the dental implant in the mouth of the patient. Gingival tissue surrounding the PSTP is permitted to heal in the mouth of the patient. In response to aesthetics of the healed gingival tissue surrounding the PSTP in the mouth of the patient not being acceptable, the PSTP is physically modified by (i) removing material from the PSTP, (ii) adding material to the PSTP, or (iii) both. The modified PSTP is scanned and a permanent prosthesis is fabricated as a replica of the modified PSTP using scan data generated from the scan of the modified PSTP.
Owner:BIOMET 3I LLC

Degradable magnesium tenting device for faster surgeries and improved outcomes in vertical ridge augmentation

ActiveUS12667449B2Mg alloysGingival tissue
The invention relates to magnesium screws and screw-like devices for dental implant surgery and, more particularly, to magnesium and magnesium-based tenting devices for implementation in periosteal and gingival tissue overlying an alveolar ridge of a mandible or maxilla to provide vertical ridge augmentation, i.e., bone regeneration. The tenting devices may be composed of magnesium in dry form, such as metallic magnesium and salts thereof; or magnesium alloy including magnesium in dry form and at least one alloying element or compound; or magnesium-polymer composite including magnesium in dry form and at least one polymer.
Owner:UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION

Application of GDF6 in preparation of medicine for detecting periodontitis or preventing and treating periodontitis

The invention discloses application of GDF6 in preparation of a medicine for detecting periodontitis or preventing and treating periodontitis, and belongs to the technical field of biological medicine. The invention finds that GDF6 is obviously reduced in periodontitis gingival tissues; the GDF6 can improve the expression of ALP, cell mineralization and the expression of osteogenic transformation related genes ALP, RUNX2 and OCN by reducing the expression of inflammatory factors of the inflammatory PDLSCs, so that the GDF6 can be used for osteogenic differentiation of the PDLSCs in an inflammatory state. In addition, the GDF6 can significantly improve the level of periodontitis of mice and alveolar bone resorption when applied in vivo, so that the GDF6 has a good treatment effect on periodontitis.
Owner:HOSPITAL OF STOMATOLOGY GUANGZHOU MEDICAL UNIVERSITY (YANGCHENG HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY)

Titanium alloy dental implant machinable abutment column

The machinable abutment column comprises an abutment column body used for connecting an implant and a dental crown, the abutment column body comprises an insertion column and a limiting round block which are fixedly connected, and a fixed round block and a convex column which are fixedly connected, and a clamping column is fixed at the central position of the bottom surface of the limiting round block; the outer cutting sleeve comprises an inner titanium alloy net layer and an inner titanium alloy cylinder layer which are fixedly connected, and an outer cutting layer arranged on the outer sides of the inner titanium alloy net layer and the inner titanium alloy cylinder layer; the designed outer cutting sleeve is composed of an outer cutting layer, an inner titanium alloy net layer and an inner titanium alloy cylinder layer, and the outer cutting layer is made of a composite material composed of glass fibers and a resin matrix, so that the outer cutting layer can be conveniently cut by a cutter, and the surface shape of the outer cutting layer is attached to gingival tissue and a dental crown; the effect of limiting the insertion column is achieved, the insertion column is prevented from loosening, and the connection between the abutment column body and the implant is further reinforced.
Owner:JIANGSU DOMIC BIOTECHNOLOGY CO LTD

A maxillary Le Fort I type block osteotomy interdental osteotomy guide plate and manufacturing method

ActiveCN121570216BGingival tissueSuperior lip
The application discloses an interdental osteotomy guide plate for maxillary Le Fort I type block osteotomy, which comprises a bite positioning plate, an osteotomy line positioning guide plate, a buffer area and a lip baffle, wherein the upper surface of the bite positioning plate is provided with an initial tooth impression; the osteotomy line positioning guide plate is provided with a screw hole, a hollow window area and an osteotomy line position direction indicating area; the buffer area is connected between the bite positioning plate and the osteotomy line positioning guide plate and is used for avoiding orthodontic devices on the tooth surface and stripping soft tissue on the bone surface; the lip baffle is arranged above the osteotomy line positioning guide plate and is used for blocking the upper lip tissue to expose the operation area; and the gum baffle is arranged below and on the inner side of the osteotomy line position direction indicating area and is used for blocking the gum tissue to expose the osteotomy operation area. The bite positioning, the positioning of the position and direction of the osteotomy line and the soft tissue isolation function are integrated in one guide plate, so that the surgical procedure is simplified and the dependence on many assistants is reduced.
Owner:PEKING UNIV SCHOOL OF STOMATOLOGY

Application of sea buckthorn extract in the preparation of periodontitis prevention and treatment products

This invention relates to the field of pharmaceutical technology, specifically disclosing the application of sea buckthorn extract in the preparation of products for the prevention and treatment of periodontitis. The invention uses network pharmacology to predict the potential molecular mechanisms of sea buckthorn extract in preventing and treating periodontitis, and validates these mechanisms in vivo using a rat model of experimental periodontitis. Results show that sea buckthorn extract significantly improves periodontal probing depth and gingival bleeding index in rats with periodontitis, reduces the expression levels of IL-6, TNF-α, IL-1β, and MMP-9 in serum and gingival tissue, and alleviates periodontal inflammation. Simultaneously, sea buckthorn extract upregulates the expression of RUNX2, OCN, OPG, and ALP, downregulates the expression of RANKL and COX-2, inhibits osteoclast formation, improves alveolar bone resorption, and regulates bone homeostasis. This invention provides a new medical application for sea buckthorn extract, which can be used to prepare products for the prevention and / or treatment of periodontitis.
Owner:FIRST AFFILIATED HOSPITAL OF XINJIANG MEDICAL UNIVERSITY