66 results about "Vasodilation" patented technology

The invention discloses a blood protein precise active peptide capable of tonifying qi and blood, improving microcirculation and promoting vasodilation and a preparation method and application thereof, and belongs to the technical field of blood protein peptide. The blood protein precision active peptide comprises at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII or FPHFD. The prepared blood protein precision active peptide has multiple biological activities: an antihypertensive effect is achieved by inhibiting ACE and vasoconstriction substances; vasodilation is promoted by activating a PI3K / AKT / eNOS signal channel; a zebra fish model proves that the traditional Chinese medicine composition has the effects of remarkably improving microcirculation and tonifying qi and blood. The preparation method is low in equipment requirement, simple in process, easy to operate and convenient for industrial large-scale production. The method enriches a bioactive peptide library, and is of great significance in promoting technical progress and industrial upgrading in the field of hemoglobulin peptides.

The present invention relates to the technical field of arteriovenous fistulas. Provided is an optimized scheme for postoperative vasodilation of an autologous arteriovenous fistula. The optimized scheme comprises microwave and electromagnetic field stimulation, ultrasonic monitoring and AI analysis, nano-drug sustained-release technology and intelligent pressure regulation. A microwave and electromagnetic field module stimulates vascular smooth muscle by means of precisely controlling a frequency and an intensity; an ultrasound monitoring module collects real-time data on a vascular inner diameter and a blood flow volume; an AI module dynamically adjusts a stimulation intensity on the basis of the data; a nanoparticle sustained-release system realizes long-acting drug release; and a pressure regulation module automatically regulates, by means of a closed-loop control algorithm, external pressure applied to blood vessels. The problems of imprecise physical stimulation, unsustained pharmaceutical support, fixed pressure regulation, etc., in traditional management of postoperative vasodilation are effectively solved.

A system for monitoring hemodynamic effectiveness includes a lead assembly including a lead body configured to deliver electrical stimulation or to deliver a fluid. The system includes at least one stimulation source including a drug pump or a pulse generator, a sensing device configured to detect a hemodynamic property of a body part, and a processor configured to determine hemodynamic effectiveness based on the detected hemodynamic property. Hemodynamic properties may include vasodilation, vasoconstriction, increased blood flow, decreased blood flow, or other hemodynamic changes. A method for providing treatment includes positioning a lead body adjacent to a blood vessel, obtaining a baseline hemodynamic property, administering stimulation, detecting an updated hemodynamic property, and determining hemodynamic effectiveness based on a change between the baseline and updated hemodynamic properties. A closed-loop treatment system adjusts treatment values based on measurements detected by the sensing device to cause stimulation to reach target values.

A system for treating erectile dysfunction in a male person is disclosed. The system comprises a stimulation device configured to deliver, directly or indirectly: a first stimulation signal to a sympathetic nerve innervating a penile vein of the person; and a second stimulation signal to a parasympathetic nerve innervating a penile artery of the person. The system further comprises a control unit configured to control an operation of the stimulation device such that: the first stimulation signal stimulates an activity of the sympathetic nerve, thereby causing vasoconstriction of the penile vein; and the second stimulation signal stimulates an activity of the parasympathetic nerve, thereby causing vasodilation of the penile artery. The vasodilation of the penile artery increases a blood flow entering an erectile body of the penis and the vasoconstriction of the penile vein reduces a blood flow exiting the erectile body, thereby inducing engorgement of the erectile body.

The utility model relates to the technical field of internal fistula exercisers, in particular to an internal arteriovenous fistula exerciser which comprises an elbow seat, an air bag is arranged on the upper surface of the elbow seat, a grabbing mechanism convenient for a patient to grab and exercise internal fistula is arranged at the front end of the elbow seat, a telescopic groove is formed in the front end of the elbow seat, a telescopic sleeve is inserted into the telescopic groove in a sliding mode, and the telescopic sleeve is connected with the elbow seat. And the connecting frame is inserted into the front end of the telescopic sleeve in a sliding manner. According to the internal arteriovenous fistula exerciser, a one-way air inlet valve is further arranged on an air bag, so that an inflatable cuff is conveniently controlled to expand to extrude arms to promote vasodilation, arteriovenous blood deposition of upper limbs is achieved, and therefore the filling degree of internal fistula blood vessels is increased, and a telescopic sleeve connected to the front end of an elbow seat and a connecting frame are connected with an exerciser body through a rotating rod; meanwhile, the four-finger fixing belt and the thumb fixing belt are arranged on the upper side and the lower side of the exerciser main body, so that patients with different arm lengths can conveniently hold the exerciser main body for exercise.

The application relates to the use of a composition comprising N,N-dimethylglycine (DMG) and / or a salt thereof for inducing endothelium-derived NO-dependent vasodilation.

The invention provides application of lactobacillus reuteri to improvement of prostatitis and erectile dysfunction. The bacterial strain is lactobacillus reuteri NHNK-2001, the lactobacillus reuteri NHNK-2001 is preserved in the China Center for Type Culture Collection on April 25, 2024, and the preservation number of the lactobacillus reuteri NHNK-2001 is CCTCC (China Center for Type Culture Collection) NO: M 2024800. The NHNK-2001 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving prostatitis and erectile dysfunction.

This invention presents a disposable male hydrogel patch designed to delay ejaculation and prolong erection time while minimizing the impact on sexual pleasure. The patch features an ergonomically designed backing with specific curvatures, a drug-loaded strip divided into central and side zones, and an optional hydrogel coating for sustained drug release. The central zone contains a drug mixture that inhibits the dorsal nerve of the penis, while the side zones promote vasodilation related to erection. The backing includes the adjustment hole for adaptive fitting and is made of a multi-layer composite that integrates breathability, waterproofing, moisture absorption, and fixation. The drug-loaded strip incorporates herbal extracts and synthetic compounds to target the nervous system, vascular system, and endocrine system. Discrete protruding arrays at the coronal sulcus recess enhance drug delivery. This novel, multi-angle approach comprehensively improves sexual function and quality of life, making it a significant innovation in male sexual health.

This application discloses a precise active peptide of hemoglobin with the functions of replenishing qi and blood, improving microcirculation, and promoting vasodilation, as well as its preparation method and application, belonging to the field of hemoglobin peptide technology. The precise active peptide of hemoglobin contains at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII, or FPHFD. The prepared precise active peptide of hemoglobin exhibits multiple biological activities: it exerts a hypotensive effect by inhibiting ACE and vasoconstrictive substances; it promotes vasodilation by activating the PI3K / AKT / eNOS signaling pathway; and it has been shown to significantly improve microcirculation and replenish qi and blood in a zebrafish model. The preparation method has low equipment requirements, is simple and easy to operate, and is suitable for large-scale industrial production. This invention enriches the bioactive peptide library and is of great significance for promoting technological progress and industrial upgrading in the field of hemoglobin peptides.

The invention discloses an application of a nitrobenzene-containing urea compound in preparation of an anti-allergic reaction drug, and the nitrobenzene-containing urea compound can be applied in preparation of a drug for antagonizing mouse sole swelling and plasma exosmosis caused by C48 / 80. The invention also discloses application of the compound in preparation of drugs for antagonizing mouse sole skin vasodilation and mast cell degranulation caused by C48 / 80. The nitrobenzene-containing urea compound can effectively relieve mouse sole swelling and plasma exosmosis, mouse sole skin vasodilation and mast cell degranulation caused by C48 / 80, reduce serum histamine release and relieve body temperature decline, so that the occurrence of anaphylactoid reaction is inhibited, and the nitrobenzene-containing urea compound can be used for preventing and treating hyperplasia. Therefore, when the nitrobenzene-containing urea compound is used as an anti-drug anaphylaxis preparation, more possible treatment schemes are provided for clinical drug anaphylaxis treatment.

The invention discloses application of sulforaphane in preparation of a medicine for treating vascular endothelial impairment, and relates to the technical field of medicines. In-vitro cell experiments prove that the sulforaphane can effectively relieve inflammatory response and activation state of endothelial cells by inhibiting expression of classical adhesion molecules such as SELE, VCAM1 and ICAM1 and various chemotactic factors, so that TNF-alpha induced monocyte adhesion is inhibited; besides, the sulforaphane enhances the anti-oxidation defense capability of endothelial cells by activating an Nrf2 signal channel, effectively relieves oxidative stress injury and plays a role in protecting endothelium; animal experiments further prove that in an atherosclerosis and hypertension mouse model, the sulforaphane down-regulates the expression of adhesion molecules in endothelial cells and up-regulates the expression of antioxidant proteins and vasodilatation promoting proteins at the same time, so that the obvious anti-atherosclerosis and antihypertensive effects are achieved.

A device and mobile apparatus for monitoring health are provided. The device for monitoring health according to embodiments of this disclosure includes: a pulse wave sensor configured to acquire a first pulse wave signal from an object in a first contact state and a second pulse wave signal in a second contact state; and a processor configured to estimate the degree of vasodilation based on the AC component of each of the first and second pulse wave signals, and to monitor vascular health based on the estimated degree of vasodilation.

The present invention discloses a dimer of Glu-Arg-Ala, namely [Glu-Arg-Ala]2, and discloses its preparation method and application in the treatment of vasoconstrictive diseases. Experiments have proved that [Glu-Arg-Ala]2 of the present invention not only has a good vasodilatory effect, but also the vasodilatory effect is significantly stronger than that of Glu-Arg-Ala. Therefore, it is proposed that the present invention provides an effective technical means for vasodilation.

The present invention discloses a composition containing tyrosol and amino acids, and its application in enhancing athletic performance and anti-fatigue. The amino acids are citrulline and / or arginine. The supplementation of tyrosol in combination with citrulline and / or arginine can increase the rate of nitric oxide production and extend the duration of nitric oxide activity, promoting vasodilation and blood flow. This, in turn, enhances athletic performance, improves endurance, and combats fatigue.

Injecting botulinum toxin directly into the clitoris can treat various sexual dysfunctions and improve sexual satisfaction in many women. Without wishing to be bound by this hypothesis, these effects of botulinum toxin may act by, inter alia, increasing arterial blood flow within the clitoris via vasodilation, neovascularization within the clitoris, neurogenesis within the clitoris, changing autonomic tone, and activating the mid-hypothalamus.

The invention discloses a nitrosohemoglobin-loaded membrane fusion bionic nano-carrier as well as a preparation method and application of the nitrosohemoglobin-loaded membrane fusion bionic nano-carrier. According to the membrane fusion bionic nano-carrier, a membrane shell is formed by hybridizing and fusing synthetic phospholipid and a platelet membrane, an aqueous solution of nitrosohemoglobin is encapsulated in the membrane shell, and the nitrosohemoglobin is prepared by carrying out deoxidation treatment on hemoglobin and then reacting the treated hemoglobin with nitric oxide molecules; the membrane fusion bionic nano-carrier has good biocompatibility and natural targeting property, and can quickly and efficiently target the focus of cardiovascular and cerebrovascular diseases, and the delivered nitrosohemoglobin not only retains the biological activity of vasodilation and the like of nitric oxide gas molecules, but also has paramagnetism, can effectively enhance the magnetic resonance development effect, and can be used for preparing a biological medicine for treating cardiovascular and cerebrovascular diseases. And a new tool can be provided for effective delivery of nitric oxide molecules in ischemic cardiovascular and cerebrovascular disease lesions and magnetic resonance imaging diagnosis as a carrier.

The present invention discloses a composition containing tyrosol and amino acids, and its application in enhancing athletic performance and anti-fatigue. The amino acids are citrulline and / or arginine. The supplementation of tyrosol in combination with citrulline and / or arginine can increase the rate of nitric oxide production and extend the duration of nitric oxide activity, promoting vasodilation and blood flow. This, in turn, enhances athletic performance, improves endurance, and combats fatigue.

The invention relates to a composition and a preparation method of a reproduction nursing external preparation with effects of inhibiting bacteria, relieving and improving male functions. The invention discloses an external preparation for male reproduction nursing. The plant essential oil comprises natural plant extracts (clove, herba epimedii, ginseng, dendrobium officinale, tribulus terrestris, radix sophorae flavescentis, fructus cnidii, saw palmetto fruit and aloe vera), nutritional ingredients (arginine, hydrolyzed collagen zinc, nicotinic acid, tocopherol, biotin and B-group vitamin yeast polypeptide) and compound essential oil (tea tree oil, jasmine flower oil, iris oil, cananga odorata flower oil and sandalwood oil). The composition can be prepared into spray, cream, lotion and other dosage forms. The preparation improves erectile function, enhances microcirculation, relieves pressure, improves sexual desire and realizes precise adjustment of male function and protection of gonad axis through mechanisms of inhibiting bacteria, diminishing inflammation, improving testosterone concentration, enhancing nitric oxide synthase activity, promoting vasodilatation, blocking neural signals, delaying ejaculation and the like.

This invention discloses a PICC placement auxiliary device, relating to the field of PICC placement technology, to facilitate injection by medical personnel. The device includes a placement frame, a rotating plate, a handle, a heating plate, a rotating rod, and a limiting mechanism. The placement frame is connected to symmetrically arranged rotating plates via the rotating rod. The handle is slidably connected to the rotating plates, and the heating plate is connected to the handle. The placement frame is equipped with the limiting mechanism, which is used to limit the patient's forearm. This invention allows the user to hold the handle and place the heating plate against the patient's forearm. The heating plate heats the injection site in the forearm, raising the temperature of the blood vessels and causing vasodilation, thus facilitating injection by medical personnel.

The application provides application of a carbazole derivative Y16 in preparation of a drug for treating cardiovascular diseases, and belongs to the technical field of medicines.The vasodilatation activity of Y16 is determined by using a rat isolated thoracic aorta tension measurement, and the change of the vasodilatation effect of Y16 under the intervention of various channel inhibitors is observed, and the influence of Y16 on blood pressure is determined by using a rat femoral artery cannulation experiment.The results show that the carbazole derivative Y16 has a good dose-dependent vasodilatation effect, and Y16 also shows a blood pressure lowering effect, so that the carbazole derivative Y16 can effectively treat cardiovascular diseases is disclosed for the first time, the application provides a theoretical basis for obtaining a candidate compound of a drug for treating cardiovascular diseases, and also provides a new selection for a drug for treating cardiovascular diseases in clinic.

The present invention relates to a pharmaceutical composition that comprises a lipid emulsion and thus inhibits nitric oxide production, thereby inhibiting vasodilation.

The invention relates to an immunomodulatory substance(s) and / or a skin-conditioning agent for use in a method for treating and / or preventing an antisynthetase syndrome in a subject, wherein the method comprises a step (A) selected from one or more of: generating an accumulation of PBMCs within the skin, generating a vasodilation of the capillaries within the skin, generating an increased blood volume within the skin, generating an increased sO2 within the skin, generating an increased rHb within the skin, generating an increased temperature on the skin, generating a redness on the skin, administering conditioning energy to the skin, administering a skin-conditioning agent to the skin or administering PBMCs to the skin of the subject; and the method further comprises step (B) administering a first immunomodulatory substance(s) to the skin of the subject and / or step (C) administering a second immunomodulatory substance(s) to the skin of the subject.

The present disclosure provides a compound for specifically enhancing the spatial coupling degree of a TRPV4-KCa2.3 complex and use thereof, and belongs to the field of chemical medicine. The compound with a structure shown in a general formula (I) in the present disclosure is mainly used for re-coupling two uncoupled proteins and restoring the proteins to a normal state under uncoupling of TRPV4 and KCa2.3 in hypertensive patients. Under normal conditions of the TRPV4 and the KCa2.3, a signal of calcium ions is received by the TRPV4. As the calcium ions flow in, potassium ions in a KCa2.3 channel in the downstream are stimulated to flow out. Due to depolarization, vasodilation is caused, and therefore, the blood pressure of the hypertensive patients is returned to a normal level.

To provide compositions with hypotensive and / or anti-stress effects that allows humans to easily orally ingest while containing choline ester such as acetylcholine as an active ingredient.SOLUTION: Objects of the present invention are to provide a novel composition for oral ingestion that allows humans to ingest choline ester such as acetylcholine easily orally and has hypotensive and vasodilatory effects, and to provide a food that is a useful source for that purpose.SELECTED DRAWING: Figure 2

The invention belongs to the technical field of medical chemistry, and particularly relates to a preparation method and application of eicosapentaenoic acid-2-(1H-indole-3-yl) ethyl ester. According to the preparation method of the eicosapentaenoic acid-2-(1H-indole-3-yl) ethyl ester, provided by the invention, 2-(3-indolyl) ethanol and eicosapentaenoic acid are used as raw materials, and lipase is added to react and synthesize the eicosapentaenoic acid-2-(1H-indole-3-yl) ethyl ester. The eicosapentaenoic acid-2-(1H-indole-3-yl) ethyl ester prepared by the preparation method disclosed by the invention has an excellent and comprehensive lipid-lowering effect, not only can effectively reduce the contents of triglyceride, total cholesterol and low-density lipoprotein cholesterol in serum, but also can effectively increase the level of high-density lipoprotein cholesterol. Meanwhile, the compound also has a strong direct blood vessel protection effect, can remarkably repair vascular endothelial dysfunction caused by high-fat diet and effectively recover endothelium-dependent vasodilatation capability, and is a safe and effective novel cardiovascular disease medicine.

The application discloses an anesthesia hypotension prediction method and system based on FMD data mining of a grey system, and belongs to the field of electric digital data processing. The application carries out preprocessing, interval grey number conversion and dimension standardization processing on brachial artery blood flow mediated vasodilation function data and clinical baseline data, generates a standardized interval grey number feature set, completes feature screening and coupling relationship mining through grey nonlinear correlation analysis, completes risk simulation calculation through a non-equidistant metabolism GM(1, N) power model, and divides and outputs a hypotension risk level after anesthesia induction relying on grey clustering evaluation. The system is electrically connected by multiple functional modules in sequence, and can realize missing data completion, model precision verification and feature contribution output. The application is suitable for a poor information small sample scene, reduces the interference of data uncertainty and dimension difference, improves the reliability and interpretability of risk prediction, and provides evaluation support for perioperative hemodynamic management.

The invention relates to the field of medicine, in particular to a nitrite donor-albumin coupling medicine and a preparation method and application thereof. According to the nitrite donor-albumin coupling drug disclosed by the invention, an intelligent drug delivery system with a pH response characteristic is constructed by covalently coupling a nitrite donor compound or a derivative thereof and albumin, so that the bottleneck problems of short half-life period (lt: 1h), non-specific release, poor blood-brain barrier penetrability and the like of a traditional nitrite drug are effectively solved. The coupling medicine can significantly improve cerebral ischemia reperfusion injury through vasodilation regulation and oxidation resistance, and the infarct area is significantly reduced (about 2 times). The breakthrough provides a brand new normal form for developing cerebral apoplexy treatment medicines with targeting accuracy and multi-dimensional treatment, and has important clinical transformation value.

Neuromodulation of the lumbar sympathetic chain can cause vasodilation in at least one of a subject's legs. At least two electrode contacts can be interfaced with the lumbar sympathetic chain of a subject; and an electrical signal can be delivered to the lumbar sympathetic chain via the at least two electrode contacts to cause the vasodilation.

A method for quantitative measurement of cerebral vascular reactivity (CVR) combines sequential gas delivery with ΔR2*-based perfusion analysis. Sequential gas delivery imposes a first stepwise reoxygenation after a first hypoxic condition and a second stepwise reoxygenation after a second hypoxic condition. In one mode, the second hypoxic condition produces greater vasodilation than the first; in another mode both hypoxia levels are minimal and an independent vasoactive stimulus, such as hypercapnia or acetazolamide, is applied between reoxygenations. MRI gradient-echo imaging records the ΔR2* time course in a target voxel during each reoxygenation. Sigmoid fitting yields perfusion metrics including relative cerebral blood flow, relative cerebral blood volume and mean transit time. Comparison of the metrics derived from the two reoxygenations provides a numerical CVR value that can be reproduced across sessions and subjects.