169 results about "Vasodilation" patented technology

The invention discloses a chest CT (Computed Tomography) image processing method and system, and relates to the technical field of medical image processing, and the main scheme is as follows: acquiring image data of two groups of X-rays with different energies and attenuation measurement values of pixel points by adopting dual-energy CT scanning, respectively calculating concentration values of soft tissues and blood vessels, and generating concentration maps; generating an initial image based on the soft tissue and blood vessel concentration map, calculating a pixel value, obtaining a target image pixel value through contrast stretching, segmenting the target image pixel value to obtain a binary image, and distinguishing a blood vessel region and a soft tissue region in the binary image by identifying and analyzing a connected region in the binary image; carrying out center line extraction on the blood vessel region, calculating a local diameter, and respectively comparing the local diameter with a blood vessel dilation threshold value and a blood vessel constriction threshold value to judge abnormal blood vessel dilation or constriction; extracting features from the soft tissue region to form a first feature vector, and comparing the first feature vector with a preset second feature vector to judge abnormality; abnormal conditions are automatically labeled or highlighted, so that the diagnosis accuracy and efficiency are improved.

An apparatus and method are used to deliver an electrical current to, through or across gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, cosmetic, and or regenerative benefits. These benefits include killing or modifying oral microbes, increasing oral vasodilation, reducing oral biofilm, improving blood oral circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens. Use of systems and methods according to the present invention may effectively tighten epithelial contact with one or more teeth (e.g., by the junctional epithelium and / or the sulcular epithelium) and / or cause a tightening of the oral epithelium, thereby improving an appearance of a human smile.

A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.

A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.

The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and / or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and / or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.

The invention discloses a blood protein precise active peptide capable of tonifying qi and blood, improving microcirculation and promoting vasodilation and a preparation method and application thereof, and belongs to the technical field of blood protein peptide. The blood protein precision active peptide comprises at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII or FPHFD. The prepared blood protein precision active peptide has multiple biological activities: an antihypertensive effect is achieved by inhibiting ACE and vasoconstriction substances; vasodilation is promoted by activating a PI3K / AKT / eNOS signal channel; a zebra fish model proves that the traditional Chinese medicine composition has the effects of remarkably improving microcirculation and tonifying qi and blood. The preparation method is low in equipment requirement, simple in process, easy to operate and convenient for industrial large-scale production. The method enriches a bioactive peptide library, and is of great significance in promoting technical progress and industrial upgrading in the field of hemoglobulin peptides.

A wearable device comprising a first array of non-optical sensing nodes is disclosed. The first array comprises a plurality of nodes. The plurality of nodes are operable to sense vasodilation of an artery in proximity to the first array. Systems and methods for determining a difference between a first position and a first reference position of the first array relative to a first artery are disclosed. First signal information may be received from the wearable device. The first signal information may represent first signal variation data sensed by each node of the first array. A first position of the first array relative to a first artery may be determined based on a first signal variation pattern in the first signal information. A difference between the first position and a first reference position of the first array relative to the first artery may then be determined.

The present invention relates to the technical field of arteriovenous fistulas. Provided is an optimized scheme for postoperative vasodilation of an autologous arteriovenous fistula. The optimized scheme comprises microwave and electromagnetic field stimulation, ultrasonic monitoring and AI analysis, nano-drug sustained-release technology and intelligent pressure regulation. A microwave and electromagnetic field module stimulates vascular smooth muscle by means of precisely controlling a frequency and an intensity; an ultrasound monitoring module collects real-time data on a vascular inner diameter and a blood flow volume; an AI module dynamically adjusts a stimulation intensity on the basis of the data; a nanoparticle sustained-release system realizes long-acting drug release; and a pressure regulation module automatically regulates, by means of a closed-loop control algorithm, external pressure applied to blood vessels. The problems of imprecise physical stimulation, unsustained pharmaceutical support, fixed pressure regulation, etc., in traditional management of postoperative vasodilation are effectively solved.

Methods of improving athletic performance in a human, increasing the bioabsorption of the compound in a human, or of increasing the vasodilative characteristics in a human comprise administering to the human compositions and supplement formulations comprising a compound selected from the group consisting of Carnitine, Taurine, and derivative forms thereof; and a Nitrate are disclosed.

A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and / or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and / or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.

The invention provides a tillite health-care wine production process, and relates to the technical field of health-care wine brewage, the tillite health-care wine production process comprises the following steps: S1, raw material preparation, S2, raw material treatment: crushing the dried raw materials through crushing operation; s3, stirring: putting the powdery raw materials formed in the step S2 into a reaction kettle; s4, purifying and filtering; s5, cooking: cooking the tillite extracting solution and common food materials for wine brewing; s6, performing fermentation: performing fermentation on the food material extracting solution obtained in the step S5, honey and yeast together; s7, sterilization and disinfection; s8, blending: blending the sterilized raw stock of the brewed wine in the S7 with distilled wine; s9; performing packaging; the traditional Chinese medicine composition is helpful for regulating the metabolic process in the body and regulating blood fat, insulin sensitivity and vasodilation, so that blood sugar, blood pressure and blood fat are reduced; and by taking a proper amount of the health-care tea, the immunity can be enhanced, the beauty is maintained, the senescence is delayed and the sexual function is improved.

A system for monitoring hemodynamic effectiveness includes a lead assembly including a lead body configured to deliver electrical stimulation or to deliver a fluid. The system includes at least one stimulation source including a drug pump or a pulse generator, a sensing device configured to detect a hemodynamic property of a body part, and a processor configured to determine hemodynamic effectiveness based on the detected hemodynamic property. Hemodynamic properties may include vasodilation, vasoconstriction, increased blood flow, decreased blood flow, or other hemodynamic changes. A method for providing treatment includes positioning a lead body adjacent to a blood vessel, obtaining a baseline hemodynamic property, administering stimulation, detecting an updated hemodynamic property, and determining hemodynamic effectiveness based on a change between the baseline and updated hemodynamic properties. A closed-loop treatment system adjusts treatment values based on measurements detected by the sensing device to cause stimulation to reach target values.

A system for treating erectile dysfunction in a male person is disclosed. The system comprises a stimulation device configured to deliver, directly or indirectly: a first stimulation signal to a sympathetic nerve innervating a penile vein of the person; and a second stimulation signal to a parasympathetic nerve innervating a penile artery of the person. The system further comprises a control unit configured to control an operation of the stimulation device such that: the first stimulation signal stimulates an activity of the sympathetic nerve, thereby causing vasoconstriction of the penile vein; and the second stimulation signal stimulates an activity of the parasympathetic nerve, thereby causing vasodilation of the penile artery. The vasodilation of the penile artery increases a blood flow entering an erectile body of the penis and the vasoconstriction of the penile vein reduces a blood flow exiting the erectile body, thereby inducing engorgement of the erectile body.

The utility model relates to the technical field of internal fistula exercisers, in particular to an internal arteriovenous fistula exerciser which comprises an elbow seat, an air bag is arranged on the upper surface of the elbow seat, a grabbing mechanism convenient for a patient to grab and exercise internal fistula is arranged at the front end of the elbow seat, a telescopic groove is formed in the front end of the elbow seat, a telescopic sleeve is inserted into the telescopic groove in a sliding mode, and the telescopic sleeve is connected with the elbow seat. And the connecting frame is inserted into the front end of the telescopic sleeve in a sliding manner. According to the internal arteriovenous fistula exerciser, a one-way air inlet valve is further arranged on an air bag, so that an inflatable cuff is conveniently controlled to expand to extrude arms to promote vasodilation, arteriovenous blood deposition of upper limbs is achieved, and therefore the filling degree of internal fistula blood vessels is increased, and a telescopic sleeve connected to the front end of an elbow seat and a connecting frame are connected with an exerciser body through a rotating rod; meanwhile, the four-finger fixing belt and the thumb fixing belt are arranged on the upper side and the lower side of the exerciser main body, so that patients with different arm lengths can conveniently hold the exerciser main body for exercise.

The application relates to the use of a composition comprising N,N-dimethylglycine (DMG) and / or a salt thereof for inducing endothelium-derived NO-dependent vasodilation.

The invention provides application of lactobacillus reuteri to improvement of prostatitis and erectile dysfunction. The bacterial strain is lactobacillus reuteri NHNK-2001, the lactobacillus reuteri NHNK-2001 is preserved in the China Center for Type Culture Collection on April 25, 2024, and the preservation number of the lactobacillus reuteri NHNK-2001 is CCTCC (China Center for Type Culture Collection) NO: M 2024800. The NHNK-2001 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving prostatitis and erectile dysfunction.

The present invention pertains to pneumatic compression articles that implement air¬ based inflation technology through a built-in network of air bladders. The pressure generated through pneumatic inflation creates adjustable and controlled resistance in addition to the benefits of traditional compression. The network of individual air cells that line the interior of the articles are inflated to create a combination of compression and resistance. This results in vasodilation and more blood flow, thereby promoting an increase in healing stressed or damaged tissue and eliminate soft tissue injury and to help promote the production of collagen production. Features enabling ischemic preconditioning, cryotherapy, and thermotherapy are also implemented. The present invention may also be incorporated into other articles, such as pants and swimsuits.

This invention presents a disposable male hydrogel patch designed to delay ejaculation and prolong erection time while minimizing the impact on sexual pleasure. The patch features an ergonomically designed backing with specific curvatures, a drug-loaded strip divided into central and side zones, and an optional hydrogel coating for sustained drug release. The central zone contains a drug mixture that inhibits the dorsal nerve of the penis, while the side zones promote vasodilation related to erection. The backing includes the adjustment hole for adaptive fitting and is made of a multi-layer composite that integrates breathability, waterproofing, moisture absorption, and fixation. The drug-loaded strip incorporates herbal extracts and synthetic compounds to target the nervous system, vascular system, and endocrine system. Discrete protruding arrays at the coronal sulcus recess enhance drug delivery. This novel, multi-angle approach comprehensively improves sexual function and quality of life, making it a significant innovation in male sexual health.

This application discloses a precise active peptide of hemoglobin with the functions of replenishing qi and blood, improving microcirculation, and promoting vasodilation, as well as its preparation method and application, belonging to the field of hemoglobin peptide technology. The precise active peptide of hemoglobin contains at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII, or FPHFD. The prepared precise active peptide of hemoglobin exhibits multiple biological activities: it exerts a hypotensive effect by inhibiting ACE and vasoconstrictive substances; it promotes vasodilation by activating the PI3K / AKT / eNOS signaling pathway; and it has been shown to significantly improve microcirculation and replenish qi and blood in a zebrafish model. The preparation method has low equipment requirements, is simple and easy to operate, and is suitable for large-scale industrial production. This invention enriches the bioactive peptide library and is of great significance for promoting technological progress and industrial upgrading in the field of hemoglobin peptides.

The invention discloses an application of a nitrobenzene-containing urea compound in preparation of an anti-allergic reaction drug, and the nitrobenzene-containing urea compound can be applied in preparation of a drug for antagonizing mouse sole swelling and plasma exosmosis caused by C48 / 80. The invention also discloses application of the compound in preparation of drugs for antagonizing mouse sole skin vasodilation and mast cell degranulation caused by C48 / 80. The nitrobenzene-containing urea compound can effectively relieve mouse sole swelling and plasma exosmosis, mouse sole skin vasodilation and mast cell degranulation caused by C48 / 80, reduce serum histamine release and relieve body temperature decline, so that the occurrence of anaphylactoid reaction is inhibited, and the nitrobenzene-containing urea compound can be used for preventing and treating hyperplasia. Therefore, when the nitrobenzene-containing urea compound is used as an anti-drug anaphylaxis preparation, more possible treatment schemes are provided for clinical drug anaphylaxis treatment.

The embodiment of the invention provides a peripheral blood vessel function index obtaining device. The peripheral blood vessel function index obtaining device is used for executing the following method: receiving blood pressure parameters of a resting state and a congestive state of a target peripheral artery blood vessel; receiving blood flow parameters of a resting state and a congestive state of the target peripheral artery blood vessel, wherein the blood flow parameters comprise blood flow or blood flow velocity; according to the blood pressure parameter of the resting state and the blood flow parameter of the resting state, a blood flow resistance reference value of the resting state is obtained; acquiring a blood flow resistance reference value of the congestive state according to the blood pressure parameter of the congestive state and the blood flow parameter of the congestive state; and obtaining the ratio of the blood flow resistance reference value in the resting state to the blood flow resistance reference value in the congestive state. By acquiring the ratio of the blood flow resistance reference value in the resting state to the blood flow resistance reference value in the congestive state, the blood supply reserve released by the blood supply network when the organ corresponding to the target peripheral artery blood vessel is converted from the resting state to the congestive state can be reflected, so that the retained blood vessel dilatation and the overall blood supply condition of the organ are evaluated.

The invention discloses application of sulforaphane in preparation of a medicine for treating vascular endothelial impairment, and relates to the technical field of medicines. In-vitro cell experiments prove that the sulforaphane can effectively relieve inflammatory response and activation state of endothelial cells by inhibiting expression of classical adhesion molecules such as SELE, VCAM1 and ICAM1 and various chemotactic factors, so that TNF-alpha induced monocyte adhesion is inhibited; besides, the sulforaphane enhances the anti-oxidation defense capability of endothelial cells by activating an Nrf2 signal channel, effectively relieves oxidative stress injury and plays a role in protecting endothelium; animal experiments further prove that in an atherosclerosis and hypertension mouse model, the sulforaphane down-regulates the expression of adhesion molecules in endothelial cells and up-regulates the expression of antioxidant proteins and vasodilatation promoting proteins at the same time, so that the obvious anti-atherosclerosis and antihypertensive effects are achieved.

A condition classifying device includes: an input interface configured to receive first data corresponding to a blood refilling state after ischemia of a subject, and second data corresponding to a physiological parameter that exhibits changes caused by vasodilation of the subject; a processor configured to perform a classification of a condition of the subject related to sepsis based on the first data and the second data; and an output interface configured to output a result of the classification.

The present invention involves recovering pulmonary inflammation, pulmonary edema or pulmonary capillary vasodilation symptoms caused by infection with viruses, particularly, coronavirus, and furthermore, has the effect of regenerating alveoli, and thus can effectively prevent, ameliorate or treat coronavirus infection or diseases caused by coronavirus infection.

The invention belongs to the technical field of biomedicine, and particularly relates to application of a paris polyphylla aqueous extract in treatment of psoriasis, the paris polyphylla aqueous extract can relieve inflammatory response of a psoriasis patient, is beneficial to improving vasodilatation of the psoriasis patient, and can treat the psoriasis by adjusting immune inflammatory response. The traditional Chinese medicine composition can improve interference of whole body metabolism of psoriasis patients and chronic inflammation, and also has an effect of inhibiting epidermis thickening. Therefore, the paris polyphylla aqueous extract is helpful for improving psoriasis.

A device and mobile apparatus for monitoring health are provided. The device for monitoring health according to embodiments of this disclosure includes: a pulse wave sensor configured to acquire a first pulse wave signal from an object in a first contact state and a second pulse wave signal in a second contact state; and a processor configured to estimate the degree of vasodilation based on the AC component of each of the first and second pulse wave signals, and to monitor vascular health based on the estimated degree of vasodilation.

A carotid vasodilator device for use in the treatment of conditions such as carotid artery occlusion in the neck, comprising: - a coil that enables the generation of a pulsed magnetic field, - a control unit (1) which enables the control of magnetic field signals and the adjustment of the pulsed magnetic field parameters applied to the neck area, - a cervical collar (9) providing endothelial nitric oxide synthase-mediated nitric oxide synthesis in the intact endothelial layer of the carotid artery on the inner surface of the neck by applying a regional pulsed magnetic field.

The present invention discloses a dimer of Glu-Arg-Ala, namely [Glu-Arg-Ala]2, and discloses its preparation method and application in the treatment of vasoconstrictive diseases. Experiments have proved that [Glu-Arg-Ala]2 of the present invention not only has a good vasodilatory effect, but also the vasodilatory effect is significantly stronger than that of Glu-Arg-Ala. Therefore, it is proposed that the present invention provides an effective technical means for vasodilation.

The present invention discloses a composition containing tyrosol and amino acids, and its application in enhancing athletic performance and anti-fatigue. The amino acids are citrulline and / or arginine. The supplementation of tyrosol in combination with citrulline and / or arginine can increase the rate of nitric oxide production and extend the duration of nitric oxide activity, promoting vasodilation and blood flow. This, in turn, enhances athletic performance, improves endurance, and combats fatigue.