33 results about "Vasodilation" patented technology

The invention discloses a blood protein precise active peptide capable of tonifying qi and blood, improving microcirculation and promoting vasodilation and a preparation method and application thereof, and belongs to the technical field of blood protein peptide. The blood protein precision active peptide comprises at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII or FPHFD. The prepared blood protein precision active peptide has multiple biological activities: an antihypertensive effect is achieved by inhibiting ACE and vasoconstriction substances; vasodilation is promoted by activating a PI3K / AKT / eNOS signal channel; a zebra fish model proves that the traditional Chinese medicine composition has the effects of remarkably improving microcirculation and tonifying qi and blood. The preparation method is low in equipment requirement, simple in process, easy to operate and convenient for industrial large-scale production. The method enriches a bioactive peptide library, and is of great significance in promoting technical progress and industrial upgrading in the field of hemoglobulin peptides.

A system for monitoring hemodynamic effectiveness includes a lead assembly including a lead body configured to deliver electrical stimulation or to deliver a fluid. The system includes at least one stimulation source including a drug pump or a pulse generator, a sensing device configured to detect a hemodynamic property of a body part, and a processor configured to determine hemodynamic effectiveness based on the detected hemodynamic property. Hemodynamic properties may include vasodilation, vasoconstriction, increased blood flow, decreased blood flow, or other hemodynamic changes. A method for providing treatment includes positioning a lead body adjacent to a blood vessel, obtaining a baseline hemodynamic property, administering stimulation, detecting an updated hemodynamic property, and determining hemodynamic effectiveness based on a change between the baseline and updated hemodynamic properties. A closed-loop treatment system adjusts treatment values based on measurements detected by the sensing device to cause stimulation to reach target values.

The utility model relates to the technical field of internal fistula exercisers, in particular to an internal arteriovenous fistula exerciser which comprises an elbow seat, an air bag is arranged on the upper surface of the elbow seat, a grabbing mechanism convenient for a patient to grab and exercise internal fistula is arranged at the front end of the elbow seat, a telescopic groove is formed in the front end of the elbow seat, a telescopic sleeve is inserted into the telescopic groove in a sliding mode, and the telescopic sleeve is connected with the elbow seat. And the connecting frame is inserted into the front end of the telescopic sleeve in a sliding manner. According to the internal arteriovenous fistula exerciser, a one-way air inlet valve is further arranged on an air bag, so that an inflatable cuff is conveniently controlled to expand to extrude arms to promote vasodilation, arteriovenous blood deposition of upper limbs is achieved, and therefore the filling degree of internal fistula blood vessels is increased, and a telescopic sleeve connected to the front end of an elbow seat and a connecting frame are connected with an exerciser body through a rotating rod; meanwhile, the four-finger fixing belt and the thumb fixing belt are arranged on the upper side and the lower side of the exerciser main body, so that patients with different arm lengths can conveniently hold the exerciser main body for exercise.

This application discloses a precise active peptide of hemoglobin with the functions of replenishing qi and blood, improving microcirculation, and promoting vasodilation, as well as its preparation method and application, belonging to the field of hemoglobin peptide technology. The precise active peptide of hemoglobin contains at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII, or FPHFD. The prepared precise active peptide of hemoglobin exhibits multiple biological activities: it exerts a hypotensive effect by inhibiting ACE and vasoconstrictive substances; it promotes vasodilation by activating the PI3K / AKT / eNOS signaling pathway; and it has been shown to significantly improve microcirculation and replenish qi and blood in a zebrafish model. The preparation method has low equipment requirements, is simple and easy to operate, and is suitable for large-scale industrial production. This invention enriches the bioactive peptide library and is of great significance for promoting technological progress and industrial upgrading in the field of hemoglobin peptides.

A device and mobile apparatus for monitoring health are provided. The device for monitoring health according to embodiments of this disclosure includes: a pulse wave sensor configured to acquire a first pulse wave signal from an object in a first contact state and a second pulse wave signal in a second contact state; and a processor configured to estimate the degree of vasodilation based on the AC component of each of the first and second pulse wave signals, and to monitor vascular health based on the estimated degree of vasodilation.

The present invention discloses a composition containing tyrosol and amino acids, and its application in enhancing athletic performance and anti-fatigue. The amino acids are citrulline and / or arginine. The supplementation of tyrosol in combination with citrulline and / or arginine can increase the rate of nitric oxide production and extend the duration of nitric oxide activity, promoting vasodilation and blood flow. This, in turn, enhances athletic performance, improves endurance, and combats fatigue.

The present invention discloses a composition containing tyrosol and amino acids, and its application in enhancing athletic performance and anti-fatigue. The amino acids are citrulline and / or arginine. The supplementation of tyrosol in combination with citrulline and / or arginine can increase the rate of nitric oxide production and extend the duration of nitric oxide activity, promoting vasodilation and blood flow. This, in turn, enhances athletic performance, improves endurance, and combats fatigue.

The invention relates to a composition and a preparation method of a reproduction nursing external preparation with effects of inhibiting bacteria, relieving and improving male functions. The invention discloses an external preparation for male reproduction nursing. The plant essential oil comprises natural plant extracts (clove, herba epimedii, ginseng, dendrobium officinale, tribulus terrestris, radix sophorae flavescentis, fructus cnidii, saw palmetto fruit and aloe vera), nutritional ingredients (arginine, hydrolyzed collagen zinc, nicotinic acid, tocopherol, biotin and B-group vitamin yeast polypeptide) and compound essential oil (tea tree oil, jasmine flower oil, iris oil, cananga odorata flower oil and sandalwood oil). The composition can be prepared into spray, cream, lotion and other dosage forms. The preparation improves erectile function, enhances microcirculation, relieves pressure, improves sexual desire and realizes precise adjustment of male function and protection of gonad axis through mechanisms of inhibiting bacteria, diminishing inflammation, improving testosterone concentration, enhancing nitric oxide synthase activity, promoting vasodilatation, blocking neural signals, delaying ejaculation and the like.

This invention discloses a PICC placement auxiliary device, relating to the field of PICC placement technology, to facilitate injection by medical personnel. The device includes a placement frame, a rotating plate, a handle, a heating plate, a rotating rod, and a limiting mechanism. The placement frame is connected to symmetrically arranged rotating plates via the rotating rod. The handle is slidably connected to the rotating plates, and the heating plate is connected to the handle. The placement frame is equipped with the limiting mechanism, which is used to limit the patient's forearm. This invention allows the user to hold the handle and place the heating plate against the patient's forearm. The heating plate heats the injection site in the forearm, raising the temperature of the blood vessels and causing vasodilation, thus facilitating injection by medical personnel.

The application provides application of a carbazole derivative Y16 in preparation of a drug for treating cardiovascular diseases, and belongs to the technical field of medicines.The vasodilatation activity of Y16 is determined by using a rat isolated thoracic aorta tension measurement, and the change of the vasodilatation effect of Y16 under the intervention of various channel inhibitors is observed, and the influence of Y16 on blood pressure is determined by using a rat femoral artery cannulation experiment.The results show that the carbazole derivative Y16 has a good dose-dependent vasodilatation effect, and Y16 also shows a blood pressure lowering effect, so that the carbazole derivative Y16 can effectively treat cardiovascular diseases is disclosed for the first time, the application provides a theoretical basis for obtaining a candidate compound of a drug for treating cardiovascular diseases, and also provides a new selection for a drug for treating cardiovascular diseases in clinic.

The present disclosure provides a compound for specifically enhancing the spatial coupling degree of a TRPV4-KCa2.3 complex and use thereof, and belongs to the field of chemical medicine. The compound with a structure shown in a general formula (I) in the present disclosure is mainly used for re-coupling two uncoupled proteins and restoring the proteins to a normal state under uncoupling of TRPV4 and KCa2.3 in hypertensive patients. Under normal conditions of the TRPV4 and the KCa2.3, a signal of calcium ions is received by the TRPV4. As the calcium ions flow in, potassium ions in a KCa2.3 channel in the downstream are stimulated to flow out. Due to depolarization, vasodilation is caused, and therefore, the blood pressure of the hypertensive patients is returned to a normal level.

The invention belongs to the technical field of medical chemistry, and particularly relates to a preparation method and application of eicosapentaenoic acid-2-(1H-indole-3-yl) ethyl ester. According to the preparation method of the eicosapentaenoic acid-2-(1H-indole-3-yl) ethyl ester, provided by the invention, 2-(3-indolyl) ethanol and eicosapentaenoic acid are used as raw materials, and lipase is added to react and synthesize the eicosapentaenoic acid-2-(1H-indole-3-yl) ethyl ester. The eicosapentaenoic acid-2-(1H-indole-3-yl) ethyl ester prepared by the preparation method disclosed by the invention has an excellent and comprehensive lipid-lowering effect, not only can effectively reduce the contents of triglyceride, total cholesterol and low-density lipoprotein cholesterol in serum, but also can effectively increase the level of high-density lipoprotein cholesterol. Meanwhile, the compound also has a strong direct blood vessel protection effect, can remarkably repair vascular endothelial dysfunction caused by high-fat diet and effectively recover endothelium-dependent vasodilatation capability, and is a safe and effective novel cardiovascular disease medicine.

The application discloses an anesthesia hypotension prediction method and system based on FMD data mining of a grey system, and belongs to the field of electric digital data processing. The application carries out preprocessing, interval grey number conversion and dimension standardization processing on brachial artery blood flow mediated vasodilation function data and clinical baseline data, generates a standardized interval grey number feature set, completes feature screening and coupling relationship mining through grey nonlinear correlation analysis, completes risk simulation calculation through a non-equidistant metabolism GM(1, N) power model, and divides and outputs a hypotension risk level after anesthesia induction relying on grey clustering evaluation. The system is electrically connected by multiple functional modules in sequence, and can realize missing data completion, model precision verification and feature contribution output. The application is suitable for a poor information small sample scene, reduces the interference of data uncertainty and dimension difference, improves the reliability and interpretability of risk prediction, and provides evaluation support for perioperative hemodynamic management.

The invention relates to the field of medicine, in particular to a nitrite donor-albumin coupling medicine and a preparation method and application thereof. According to the nitrite donor-albumin coupling drug disclosed by the invention, an intelligent drug delivery system with a pH response characteristic is constructed by covalently coupling a nitrite donor compound or a derivative thereof and albumin, so that the bottleneck problems of short half-life period (lt: 1h), non-specific release, poor blood-brain barrier penetrability and the like of a traditional nitrite drug are effectively solved. The coupling medicine can significantly improve cerebral ischemia reperfusion injury through vasodilation regulation and oxidation resistance, and the infarct area is significantly reduced (about 2 times). The breakthrough provides a brand new normal form for developing cerebral apoplexy treatment medicines with targeting accuracy and multi-dimensional treatment, and has important clinical transformation value.

A method for quantitative measurement of cerebral vascular reactivity (CVR) combines sequential gas delivery with ΔR2*-based perfusion analysis. Sequential gas delivery imposes a first stepwise reoxygenation after a first hypoxic condition and a second stepwise reoxygenation after a second hypoxic condition. In one mode, the second hypoxic condition produces greater vasodilation than the first; in another mode both hypoxia levels are minimal and an independent vasoactive stimulus, such as hypercapnia or acetazolamide, is applied between reoxygenations. MRI gradient-echo imaging records the ΔR2* time course in a target voxel during each reoxygenation. Sigmoid fitting yields perfusion metrics including relative cerebral blood flow, relative cerebral blood volume and mean transit time. Comparison of the metrics derived from the two reoxygenations provides a numerical CVR value that can be reproduced across sessions and subjects.

This utility model discloses a mastoid corona balloon catheter, including a balloon and a catheter. The outer surface of the balloon has an array of protrusions. A corona generator is located in the working section of the catheter within the balloon. The outer surface of the balloon has pits, with the protrusions positioned within these pits. Compared to existing technologies, by providing protrusions on the outer surface of the balloon, the balloon is instantaneously pressurized by a corona pulse. The balloon's expansion force acts on the narrowed portion of the blood vessel through the protrusions, causing the atherosclerotic plaques in the diseased blood vessel to rupture or loosen. Compared to ordinary corona pulse shockwave balloons, the protrusions on the outer surface of the balloon concentrate the balloon pulse expansion force on the blood vessel wall, especially for severely calcified vascular lesions, thus improving the effectiveness of vasodilation.

A method for the quantitative measurement of cerebral vascular reactivity (CVR) combines sequential gas delivery with ΔR2*-based perfusion analysis. The sequential gas delivery induces a first stepwise reoxygenation following an initial hypoxic state and a second stepwise reoxygenation following a second hypoxic state. In one mode, the second hypoxic state produces greater vasodilation than the first; in another mode, both hypoxia levels are minimal, and an independent vasoactive stimulus, such as hypercapnia or acetazolamide, is applied between reoxygenations. MRI gradient echo imaging records the ΔR2* time course in a target voxel during each reoxygenation. Sigmoid fitting provides perfusion metrics, including relative cerebral blood flow, relative cerebral blood volume, and mean transit time.The comparison of the measured values ​​derived from the two reoxygenations yields a numerical CVR value that is reproducible across sessions and subjects.

The invention discloses a compound substitutional tea bag with blood pressure and blood fat reducing functions and a preparation method thereof, and the compound substitutional tea bag is used for synergistically assisting in reducing blood pressure from different mechanisms through the vasodilation effect of gastrodia elata and radix puerariae, the cardiovascular protection effect of chrysanthemum and the diuretic effect of corn stigma; the hawthorn, the semen cassiae, the lotus leaves and the lucid ganoderma are used for regulating and controlling lipid absorption, synthesis and excretion in multiple links, so that the effect of assisting in reducing blood fat is jointly exerted; besides, the flavors of all the raw materials are ingeniously balanced, the sour and refreshing taste of hawthorn, the faint scent of chrysanthemum and the sweet and light taste of corn stigma effectively neutralize the slight bitter taste of semen cassiae and lotus leaves, and due to the fact that gastrodia elata, radix puerariae and lucid ganoderma do not have obvious bad flavors, final tea soup is clear in color and luster, mellow in taste, free of strong bitter taste of traditional Chinese medicine and easy to accept by consumers; the long-term drinking compliance is ensured.

The present application relates to the technical field of anti-hair loss, and particularly relates to a compound external preparation for treating hair loss. The present application provides a compound external preparation for treating hair loss, which comprises minoxidil, colatrolone, a film forming agent and a stabilizer; the mass concentration of minoxidil in the compound external preparation is 0.5-0.8%, and the mass concentration of colatrolone is 0.01-1.5%. The compound external preparation realizes the combined treatment of "vasodilation-inflammation regulation-hair follicle activation-anti-miniaturization" through the multi-target synergistic effect of two active ingredients, significantly shortens the onset time, improves the treatment efficiency, can meet the use requirements of different patients, and improves the medication compliance; meanwhile, the compound external preparation has excellent stability, and is suitable for industrial production and long-term storage.

The formulation of penile erecting gel comprises biosynthesized silver nanoparticles derived from Kaempferia parviflora extract containing 5,7-Dimethoxyflavone, in combination with sodium hyaluronate, isoprene glycol, phenoxyethanol, glycerin, propylene glycol, and ethylhexylglycerin. The manufacturing process involves blending the specified components, stirring to form a homogeneous gel, adding natural colorants and fragrances, and packaging in single-use plastic vials or aluminum foil sachets. This formulation represents an innovative application of nanotechnology in combination with Thai herbal medicine, enhancing localized vasodilation specifically at the penile region while minimizing systemic side effects such as headaches, nasal congestion, facial flushing, and blue-tinted vision associated with oral phosphodiesterase type 5 inhibitors (PDE5 inhibitors) like sildenafil (Viagra) or tadalafil (Cialis). Additionally, the gel exhibits antimicrobial and antioxidant properties.

The invention discloses application of casei paracasei in preparation of a product for improving male reproductive health, and belongs to the technical field of microorganisms. The lactobacillus paracasei NHNK-633 is preserved in the China Center for Type Culture Collection on July 7, 2025, and the preservation number of the lactobacillus paracasei NHNK-633 is CCTCC (China Center for Type Culture Collection) NO: M20251542. The NHNK-633 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving male reproductive health.

The present application discloses a composition for treating painful disc injury syndrome (PDDS), disc bulging, disc herniation, and disc herniation, as well as a delivery method and recommended treatment regimen for delivering an effective dose of the composition to a patient. The composition has the characteristics of inflammation resistance, oxidation resistance, vasodilation and spasmolysis. The composition is administered by intravenous drip over a specific period of time to relieve pain.

The invention belongs to the technical field of preparation of fermented biogen, and particularly relates to lactobacillus rhamnosus fermented biogen, a preparation method of the lactobacillus rhamnosus fermented biogen and application of the lactobacillus rhamnosus fermented biogen to improvement of atherosclerosis, reduction of thrombosis risk and regulation of ceramide metabolism. In the preparation process of the lactobacillus fermented biogen, yeast protein releases polypeptide with vasodilation and inflammation inhibition functions, and after the polypeptide is matched with anthocyanin and araboxylan oligosaccharide which have the functions of regulating ceramide metabolism and protecting the cardiovascular system, the activity of the polypeptide is improved; under the fermentation action of the lactobacillus rhamnosus NKU ML1-2, lactobacillus fermentation postbiotics with the function of protecting heart and cerebral vessels are formed, and the lactobacillus fermentation postbiotics as a dietary nutrition intervention means can directly act on vascular cells through multiple ways to promote the function repair of endothelial cells; apoptosis and oxidative damage of endothelial cells are inhibited, generation of ceramide substances is regulated, and an innovative nutrition intervention strategy is provided for prevention and treatment of atherosclerosis related diseases and prevention of thrombosis.

The invention discloses a composite herbal solid beverage assisting in lowering blood pressure and a preparation method thereof, and belongs to the technical field of food. The invention solves the problems of single effect, poor formula synergism and insufficient stability of the existing auxiliary blood pressure lowering product. According to the technical scheme, the beverage is characterized by being prepared from 30%-50% of composite cereal powder, 15%-30% of composite fruit and vegetable powder, 15%-35% of composite herbal powder, 2%-5% of wheat oligopeptide, 0.5%-2% of mogroside and 0.3%-1% of silicon dioxide. The preparation method comprises the following steps: performing ethanol extraction, concentration and spray drying on specific herbal raw materials to obtain composite herbal powder, and mixing the composite herbal powder with other components. The product is good in fluidity, fast in dissolution and good in stability, zebra fish blood vessel diameter experiments prove that the product can obviously induce vasodilation under the concentration of 1000 mu g / ml, has a definite blood pressure lowering effect, and can be used for preparing food or health-care food for assisting in lowering blood pressure.

Disclosed are a urea compound containing nitrobenzene, a preparation method therefor, and use thereof. The preparation method comprises: dissolving bis(trichloromethyl)carbonate in anhydrous tetrahydrofuran, adding a solution of 4-nitroaniline in tetrahydrofuran, stirring uniformly after dropwise addition is completed, then adding triethylamine, stirring uniformly, evaporating the solvent to dryness, adding a solution of 4-aminobenzotrifluoride in anhydrous tetrahydrofuran, and reacting at 45 °C for 3 h to obtain the urea compound containing nitrobenzene. The urea compound containing nitrobenzene can effectively alleviate the swelling and plasma extravasation of the soles of mice, and skin vasodilation and mast cell degranulation of the soles of mice, which are caused by C48 / 80, thereby inhibiting the occurrence of anaphylactoid reactions. Therefore, using the urea compound containing nitrobenzene as an anti-drug allergy formulation provides more possible treatment regimens for the clinical treatment of drug allergies.

This invention relates to the field of temperature control technology, specifically to a multi-zone dynamic sleep temperature control method based on human thermophysiological rhythms. It involves dividing the sleep support surface along the longitudinal direction of the body into multiple temperature control zones, acquiring the user's sleep stage information in real time, and then executing dynamic sleep temperature control. On one hand, during the sleep onset stage, the increased temperature in the feet triggers reflexive vasodilation of peripheral blood vessels to open heat dissipation pathways; the decreased temperature in the head lowers the hypothalamic temperature set point to enhance heat dissipation drive; and the slightly cooler torso provides a temperature gradient for core heat dissipation, thus significantly improving the rate of core body temperature decrease and significantly shortening the sleep latency. On the other hand, after entering the deep sleep maintenance stage, the method maintains the peripheral vasodilation state established during the sleep onset stage with minimal energy consumption, preventing the feet from cooling back and causing vasoconstriction, and avoiding micro-awakening triggered by torso temperature fluctuations, achieving a balance between thermal comfort and energy conservation throughout the night.

The present invention relates to a composition for preventing or treating diabetic retinopathy, comprising a peptide, wherein the peptide exhibits excellent inhibition with respect to vasodilation, loss of pericytes, and generation of neovascularity in the retina, and thus can be effectively used for preventing or treating retinopathy by inhibiting an increase in vascular permeability, inflammation, and the occurrence of neovascularity.

The present invention relates to a vasodilator for an extremity of the body, and more particularly, to a vasodilator for an extremity of the body, which, when used, improves blood circulation and physical vitality by expanding blood vessels in the extremity of the body and smoothing blood flow. To this end, the present invention includes a main body, which is made of a stretchable material and has a first receiving space formed therein into which the extremity of the body is inserted and a plurality of fine cut holes formed on its side so as to closely surround the extremity of the body inserted toward one sealed side, and a housing, which is formed therein with a second receiving space into which the main body is inserted and has an intake hole formed at one end thereof to which a pressure reducer is detachably connected, and which draws in air from the second receiving space and induces a vacuum state by the pressure reducer.

The invention discloses an adherent delivery and perfusion device for drugs in injured blood vessels, and belongs to the technical field of medical instruments. The local drug delivery device and an anchoring mechanism work cooperatively, anchoring is combined with local adherent drug delivery, so that slipping and displacement of the system can be prevented, and accurate quantitative drug release and absorption at a target lesion part are realized; the anchoring mechanism realizes two working modes of targeted local delivery of a treatment substance for blocking blood flow and targeted local delivery of a treatment substance for not blocking blood flow by means of a blood flow blocking anchoring balloon and a non-blood flow blocking net-shaped medicine elution balloon, and the two working modes can be used for local anchoring of a main branch blood vessel or a side branch blood vessel. The design of the filling holes can accurately adjust the types and doses of the medicines. The blood flow blocking mode can realize local high-concentration administration, and the non-blocking mode can control vasodilation and administration time. Through the synergistic effect of the functions, the system can optimize the operation process, improve the operation efficiency and achieve accurate and quantitative drug delivery.

This invention relates to a method of fixating and stabilizing nitric oxide metabolites through fermentation of nitrogen-containing natural substance. According to the method of the invention, the fermentation efficiency is maximized by optimizing the fermentation conditions so that the productivity of nitric oxide metabolites is significantly improved. Thus, eating a fermented natural substance in which nitric oxide metabolites are fixated and stabilized by the method of the present invention would be helpful for maintaining the homeostasis of human body, in which nitric oxide synthase is either absent or insufficient, based on vasodilation and activation of a neurotransmitter and immune function as medical efficacy of nitric oxide.