33 results about "Vasoconstriction" patented technology

The invention discloses a blood protein precise active peptide capable of tonifying qi and blood, improving microcirculation and promoting vasodilation and a preparation method and application thereof, and belongs to the technical field of blood protein peptide. The blood protein precision active peptide comprises at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII or FPHFD. The prepared blood protein precision active peptide has multiple biological activities: an antihypertensive effect is achieved by inhibiting ACE and vasoconstriction substances; vasodilation is promoted by activating a PI3K / AKT / eNOS signal channel; a zebra fish model proves that the traditional Chinese medicine composition has the effects of remarkably improving microcirculation and tonifying qi and blood. The preparation method is low in equipment requirement, simple in process, easy to operate and convenient for industrial large-scale production. The method enriches a bioactive peptide library, and is of great significance in promoting technical progress and industrial upgrading in the field of hemoglobulin peptides.

A system for monitoring hemodynamic effectiveness includes a lead assembly including a lead body configured to deliver electrical stimulation or to deliver a fluid. The system includes at least one stimulation source including a drug pump or a pulse generator, a sensing device configured to detect a hemodynamic property of a body part, and a processor configured to determine hemodynamic effectiveness based on the detected hemodynamic property. Hemodynamic properties may include vasodilation, vasoconstriction, increased blood flow, decreased blood flow, or other hemodynamic changes. A method for providing treatment includes positioning a lead body adjacent to a blood vessel, obtaining a baseline hemodynamic property, administering stimulation, detecting an updated hemodynamic property, and determining hemodynamic effectiveness based on a change between the baseline and updated hemodynamic properties. A closed-loop treatment system adjusts treatment values based on measurements detected by the sensing device to cause stimulation to reach target values.

The present invention provides a vasospasm inhibitor and an oral composition for inhibiting vasospasm that can suppress abnormal vasoconstriction (vasospasm). [Solution] A vasospasm inhibitor and an oral composition for inhibiting vasospasm, containing as an active ingredient at least one compound selected from the group consisting of 2,5-dihydroxybenzoic acid, trans-3-caffeoylquinic acid, trans-4-caffeoylquinic acid, trans-5-caffeoylquinic acid, and 2-hydroxybenzoic acid, or a salt thereof.

This application discloses a precise active peptide of hemoglobin with the functions of replenishing qi and blood, improving microcirculation, and promoting vasodilation, as well as its preparation method and application, belonging to the field of hemoglobin peptide technology. The precise active peptide of hemoglobin contains at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII, or FPHFD. The prepared precise active peptide of hemoglobin exhibits multiple biological activities: it exerts a hypotensive effect by inhibiting ACE and vasoconstrictive substances; it promotes vasodilation by activating the PI3K / AKT / eNOS signaling pathway; and it has been shown to significantly improve microcirculation and replenish qi and blood in a zebrafish model. The preparation method has low equipment requirements, is simple and easy to operate, and is suitable for large-scale industrial production. This invention enriches the bioactive peptide library and is of great significance for promoting technological progress and industrial upgrading in the field of hemoglobin peptides.

The present invention provides a scalp cooling device, including a covering part for wrapping a patient's scalp and a cooling part disposed within the covering part. This device can wrap around the patient's scalp and provide a cooling effect, causing the blood vessels in the scalp skin to constrict, reducing the blood flow to the scalp hair follicles, thereby reducing the intake of chemotherapeutic drugs by the hair follicles. Additionally, it lowers biochemical activity, thereby reducing the sensitivity of hair follicles to chemotherapy damage, and reduces the metabolic rate of the hair follicles, thus protecting the patient's hair follicles and preventing or mitigating hair loss caused by chemotherapy. Notably, the cooling part includes a gel-like coolant, which contains a moisture moderator and edible propylene glycol that maintains moisture and provides emulsifying and stabilizing effects, thus offering a long-lasting and stable cooling effect, enhancing the device's effectiveness in preventing hair loss.

The present disclosure relates to a topical aerosol deodorant composition that contains water, an organic solvent, an alpha-hydroxycarboxylic acid, one or more skin conditioning agents, optionally one or more hydrocarbon carrier agents, optionally caffeine or a xanthine derivative that has vasoconstrictive effects and a propellant. The topical aerosol deodorant composition may be sprayed onto a human's external skin in need or odor control such as the user's axilla, pudendum, feet, chest, abdomen, thigh, groin, pelvis and buttock without irritation.

This invention belongs to the field of pharmaceutical technology, specifically relating to the application of an MHC lactation modifier in the preparation of drugs for diseases related to promoting the body's lactation level. Specifically, it relates to the application of an MHC lactation modifier in the preparation of drugs for diseases related to promoting the body's lactation level, and the application of an MHC lactation modifier in the preparation of drugs for heart failure. The heart failure is defined as heart failure caused by decreased α-MHC-K1897 lactation due to Ang II-induced vasoconstriction. The invention also relates to the application of the aforementioned MHC lactation modifier in the preparation of drugs for heart failure caused by Ang II-induced vasoconstriction in humans, mice, or dogs. This invention also discovers new uses for p300 activators and SIRT1 inhibitors. Experimental studies have shown that treatment with p300 activators and SIRT1 inhibitors can affect the level of Myh6-K1897 lactation in the treatment of heart failure. The modification of Myh6-K1897 lactation as a therapeutic target plays an important role in the treatment of heart failure, providing a new approach to the treatment of heart failure.

The present invention provides a vasospasm inhibitor and an oral composition for inhibiting vasospasm that can suppress abnormal vasoconstriction (vasospasm). [Solution] A vasospasm inhibitor and an oral composition for inhibiting vasospasm, containing as an active ingredient at least one compound selected from the group consisting of 2,5-dihydroxybenzoic acid, trans-3-caffeoylquinic acid, trans-4-caffeoylquinic acid, trans-5-caffeoylquinic acid, and 2-hydroxybenzoic acid, or a salt thereof.

This invention discloses a traditional Chinese medicine composition for assisting in the improvement of hand-foot-mouth disease in infants and young children, belonging to the field of traditional Chinese medicine technology. The composition consists of eight medicinal herbs: lotus leaf, coix seed, angelica dahurica, kudzu root, platycodon root, agastache rugosa, cimicifuga rhizome, and dandelion, with a defined optimal medicinal ratio. Based on the seasonal differences in the pathogenesis of hand-foot-mouth disease, this invention targets the core pathologies of winter (cold congestion of microvessels, water and sodium retention, and internal heat generation) and spring and summer (hypothalamic sympathetic activation, increased heart rate, and visceral heat overload). It also addresses the technical deficiencies of clinical Western medicine, cold-natured traditional Chinese medicine, calamine lotion, and diuretics, such as vasoconstriction, kidney damage, central nervous system disorders, increased skin exudation, and rebound water retention. This invention employs a combination of warming and cooling herbs, regulating the ascending and descending functions, and promoting diuresis and protecting the body's vital energy. The synergistic effects of these herbs can dilate spasmodic microvessels, improve renal perfusion, stabilize abnormal heart rates, stabilize the hypothalamic center, and assist in antagonizing enteroviruses. By targeting and reducing abnormal permeability of skin capillaries with Angelica dahurica and Platycodon grandiflorus, it reduces blood extravasation and inhibits the formation and exudation of herpes from the root cause. This invention has mild medicinal properties, is suitable for all seasons, and has high safety. It can effectively improve symptoms of hand-foot-mouth disease such as fever, herpes, irritability, and cold extremities, reduce the risk of severe illness, antagonize the toxic side effects of commonly used clinical drugs, and is suitable for the delicate constitution of infants and young children, possessing good prospects for clinical application and promotion.

The invention relates to the technical field of femoral artery puncture surgical instruments, and discloses a femoral artery puncture port intelligent induction automatic protector which comprises a limiting mechanism, an angle adjusting mechanism, an angle fixing mechanism, a pressing mechanism, a pressing auxiliary mechanism and a ventilation mechanism. The angle adjusting mechanism is used for adjusting the pressing position according to the position and angle of the femoral artery, and the angle fixing mechanism is used for fixing the adjusted pressing angle, is in linkage with the pressing mechanism and can adjust the angle and position of the pressing auxiliary mechanism in the process that the pressing auxiliary mechanism gradually approaches a femoral artery puncture opening. The pressing assisting mechanism is used for accelerating wound healing and meanwhile enabling blood vessels to contract, the ventilation mechanism is used for keeping ventilation in the protector shell, bacteria breeding caused by human body sweating is prevented, and the femoral artery puncture opening is pressed and assisted in rapid healing of the femoral artery puncture opening.

The invention provides a non-inductive blood pressure continuous monitoring method and device based on single calibration and a storage medium, and the method comprises the steps: in an equipment calibration stage, in a measurement period of a pressurized sphygmomanometer, obtaining a human body monitoring signal; calculating periodic intensities of signals at different monitoring distance units based on the human body monitoring signals, and determining a target monitoring position; continuously acquiring human body monitoring signals corresponding to the target monitoring position, extracting phase change signals from the human body monitoring signals, further extracting pulse wave signals, and inputting the signals into a blood vessel feature extraction network to obtain blood vessel feature parameters; in the independent monitoring stage, continuously acquiring a human body monitoring signal corresponding to the target monitoring position; and segmenting the human body monitoring signal of the target monitoring position into multiple groups of signal segments in parallel, and inputting the signal segments and the blood vessel characteristic parameters into a pre-trained blood pressure prediction model to obtain a time sequence prediction result representing the systolic pressure and the diastolic pressure of the blood vessel. According to the invention, nighttime non-inductive blood pressure measurement can be realized, and meanwhile, the accuracy and robustness of nighttime blood pressure continuous tracking are improved.

A denervation system and method uses vasoconstriction response to stimulation to intraoperatively guide an interventional physician to understand therapy effectiveness. The denervation system and method involve receiving a first radiographic image of a blood vessel, receiving a second radiographic image of the blood vessel after treating and stimulating a target blood vessel site, and determining a first vasoconstriction metric based on the first radiographic image and the second radiographic image. The denervation system and method also involve receiving a third radiographic image and a fourth radiographic image of the blood vessel before and after stimulation of the target vascular site, respectively, prior to treating the target vascular site, and determining a second vasoconstriction metric based on the third radiographic image and the fourth radiographic image. The denervation system and method also involve outputting an indication of whether the treatment is complete based on the first vasoconstriction metric and / or the second vasoconstriction metric.

The invention discloses a novel application with a cold compress hemostasis function for hemodialysis, and relates to the technical field of medical supplies. The plaster comprises a plaster body, a first opening is formed in the plaster body, internal threads are formed in the upper side of the plaster body and located in the first opening and the inner wall of a mounting head, and bandages used for binding are arranged on the two sides of the plaster body; the hydrocolloid dressing layer is attached to the lower side of the application body. The hydrocolloid dressing layer can be directly and firmly adhered to the skin at the edge of a wound and can absorb seepage, the pressing cylinder is arranged and moves downwards by rotating the pressing cylinder so as to slowly press and stop bleeding of the wound, and the cold insulation ring is arranged so that local blood vessels around the wound can be conveniently constricted. And the traditional Chinese medicine preparation can be immediately used after dialysis, so that the wound can be scientifically nursed, and the pain of a patient can be relieved.

The present disclosure relates to a topical aerosol deodorant composition that contains water, an organic solvent, an alpha-hydroxycarboxylic acid, one or more skin conditioning agents, optionally one or more hydrocarbon carrier agents, optionally caffeine or a xanthine derivative that has vasoconstrictive effects and a propellant. The topical aerosol deodorant composition may be sprayed onto a human's external skin in need or odor control such as the user's axilla, pudendum, feet, chest, abdomen, thigh, groin, pelvis and buttock without irritation.

The present disclosure relates to compositions and methods for treating dry eye caused by, for example, tear film deficiency in the eye, by applying to the eye or surrounding area an oil-in-water emulsion composition comprising brimonidine, and optionally comprising a demulcent, e.g., a hyaluronic acid compound, in combination with inducing vasoconstriction to treat ocular conditions such as red eye (conjunctival hyperemia).

The utility model relates to the technical field of rehabilitation medical instruments, and discloses a three-section type pressurizable ice compress sleeve which comprises an ice compress sleeve body, a pressurizing sleeve is arranged on the ice compress sleeve body, the pressurizing sleeve body wraps the outer ring of the ice compress sleeve body and then is overlaid and pasted to form an adjustable enclosure structure, and a rubber ball is arranged at the air inlet end of the pressurizing sleeve body. An adjusting chock plug is arranged at the air outlet end of the pressurizing sleeve, and the adjusting chock plug is communicated with the pressurizing sleeve for deflation after moving and translating in the horizontal direction. The ice compress sleeve with the pressurization adjusting structure is formed in a double-layer combined wearing mode, the action side of an ice bag can be adjusted according to treatment requirements in a detachable mode, damage to the skin is relieved, tolerance is improved, the limb end is wrapped in a pressurization mode, vasoconstriction is stimulated, and the treatment effect is improved. Meanwhile, the situation that the ice compress effect is affected due to the fact that gaps exist between the ice bag and the limb end due to the ice bag contour and the melting degree is reduced, and the three-section structure is matched so that the wearing comfort and the fitting degree of the ice compress sleeve can be improved.

The present invention relates to an umbilical cord blood-derived vascular endothelial progenitor cell and a composition for preventing or treating ischemic diseases comprising the same, and more specifically, to an umbilical cord blood-derived vascular endothelial progenitor cell and a composition for preventing or treating ischemic diseases, the present invention relates to a high-purity umbilical cord blood-derived vascular endothelial progenitor cell exhibiting specific surface antigen characteristics, a method for obtaining an umbilical cord blood-derived vascular endothelial progenitor cell by pre-treating umbilical cord blood, and a composition for preventing and treating ischemic diseases comprising the umbilical cord blood-derived vascular endothelial progenitor cell. The high-purity umbilical cord blood-derived vascular endothelial progenitor cell of the present invention exhibits colony formation, high proliferation ability, and high potential for angiogenesis in vivo, and thus can exhibit an excellent effect on the prevention or treatment of various ischemic diseases induced by blood vessel contraction or occlusion.

Provided are thermo-responsive nitric oxide (NO) releasing molecules ("donors") and their use with polymer delivery systems. The delivery systems may include devices that allow for delivery of a dose of NO for inhalation such as portable inhalation devices. The compositions and methods may be used in the treatment of pulmonary conditions such as pulmonary hypertension, acute pulmonary vasoconstriction, respiratory distress syndrome, pulmonary edema, sepsis, and asthma. In some aspects, the compositions and methods provide a portable NO delivery mechanism allowing safe and pure NO administration outside of as well as in hospital settings.

This invention discloses a traditional Chinese medicine composition for improving otitis media, belonging to the field of traditional Chinese medicine health care technology. Addressing the shortcomings of Western medicine treatments for otitis media, which often lead to microcirculatory abnormalities and recurring symptoms, and the limitations of traditional Chinese medicine's reliance on bitter and cold herbs to block ear orifices and treat only the symptoms without addressing the root cause, this invention is based on a precise formulation of the core pathogenesis of liver and gallbladder microcirculatory disorders and gallbladder meridian stagnation and heat disturbing the ear orifices. The core ingredients of this composition are lotus leaf, angelica dahurica, jujube seed, gardenia, bergamot, and platycodon, with a scientifically reasonable ratio and mild medicinal properties. In the formula, bergamot acts as the principal ingredient to soothe the liver and gallbladder; lotus leaf and gardenia act as assistant ingredients to clear heat and promote diuresis; angelica dahurica opens the orifices and drains pus; jujube seed relieves spasms and calms the mind; and platycodon acts as the guiding ingredient to carry the medicine upwards and relax blood vessels. The synergistic effect of these herbs counteracts the vasoconstrictive side effects of bitter and cold herbs and Western medicine. This invention can improve liver and gallbladder microcirculation and inhibit the release of inflammatory factors, fundamentally resolving symptoms such as ear fullness, ear pain, and middle ear effusion caused by acute and chronic otitis media, while also improving problems such as bitter taste in the mouth and insomnia caused by liver and gallbladder stagnation and heat. This composition has significant therapeutic effects, a low recurrence rate, and no toxic side effects. It can be formulated into various preparations to suit long-term conditioning for various populations, thus making up for the technical shortcomings of existing treatment options.

The utility model provides a double-balloon thrombus extraction device, and belongs to the technical field of medical instruments. The double-balloon thrombus extraction device comprises a double-balloon catheter, a thrombus extraction tube and a sealing piece, the double-balloon catheter is movably sleeved with the thrombus extraction tube and the sealing piece, the sealing piece comprises a sleeve and a sealing ring, the sleeve is in sliding connection with the thrombus extraction tube, the sealing ring is clamped between the sleeve and the thrombus extraction tube, and the sealing ring is connected with the sleeve. The sealing ring movably abuts against the outer circle of the double-ball guide pipe. The double-ball catheter has the following effects that after the double-ball catheter fixes the embolism position and dissolves the embolism, the embolism extraction tube is moved so as to continuously go deep into the embolism position, the sealing ring is extruded every time the embolism extraction tube goes deep into the embolism position to lock the current position and seal the current position, negative pressure embolism suction can be started, the influence of vasoconstriction is avoided, and the embolism extraction efficiency is effectively improved.

The present application provides a filter, which comprises a skeleton made of bioabsorbable material, the skeleton being used to provide sufficient radial force to fix the filter in a blood vessel; a filter member made of non-absorbable filaments, the filter member comprising a filter screen and a plurality of connecting portions, the filter screen connecting the plurality of connecting portions, the connecting portions being used to connect the filter screen to the skeleton. After the skeleton is absorbed, the filter screen made of non-absorbable filaments will be long-term located in the body, the filter screen itself has no radial force, and stress distribution is uniform when the blood vessel contracts, so that the risk of filter perforation and filter fracture can be avoided.

The present disclosure relates to antiperspirant cream composition that contains water, an antiperspirant material, an alpha-hydroxycarboxylic acid, an oil agent, a structuring agent and optionally caffeine or a xanthine derivative that has vasoconstrictive effects. The antiperspirant cream composition may be applied to a human's external skin in need or odor and perspiration control such as the user's axilla, pudendum, feet, chest, abdomen, thigh, and buttock.

The invention relates to the technical field of hemodialysis dynamic regulation and control, in particular to an intelligent parameter configuration method and system for a hemodialysis device. The method comprises the following steps: firstly, acquiring an initial capacity response coefficient and a relaxed pulsation amplitude; further extracting a pipe wall shrinkage ratio, and obtaining a corrected capacity response coefficient in combination with the initial capacity response coefficient; further based on the instantaneous change of the capacity attenuation fundamental wave, combining with the corrected capacity response coefficient, and comparing with the real-time removal rate of the ultrafiltration pump to obtain the blood vessel recharging rate; further obtaining a hemodynamic load index; and finally, obtaining a current rigid demand rate based on the global task state variable. Parameters of the hemodialysis device are configured according to the current hemodynamics load index, the rigidity demand rate and the blood vessel recharging rate, the problem that due to vasoconstriction, estimation of the recharging rate by a traditional linear model is deviated is effectively solved, and conversion from lag feedback to prospective self-adaptive control is achieved.

This invention relates to the field of temperature control technology, specifically to a multi-zone dynamic sleep temperature control method based on human thermophysiological rhythms. It involves dividing the sleep support surface along the longitudinal direction of the body into multiple temperature control zones, acquiring the user's sleep stage information in real time, and then executing dynamic sleep temperature control. On one hand, during the sleep onset stage, the increased temperature in the feet triggers reflexive vasodilation of peripheral blood vessels to open heat dissipation pathways; the decreased temperature in the head lowers the hypothalamic temperature set point to enhance heat dissipation drive; and the slightly cooler torso provides a temperature gradient for core heat dissipation, thus significantly improving the rate of core body temperature decrease and significantly shortening the sleep latency. On the other hand, after entering the deep sleep maintenance stage, the method maintains the peripheral vasodilation state established during the sleep onset stage with minimal energy consumption, preventing the feet from cooling back and causing vasoconstriction, and avoiding micro-awakening triggered by torso temperature fluctuations, achieving a balance between thermal comfort and energy conservation throughout the night.

The present application relates to a kind of improving vascular senility composition and its preparation method and application, belong to natural product technical field.The present application provides a kind of improving vascular senility composition, including osmanthus fragrans extract and pumpkin seed protein peptide, the mass ratio of osmanthus fragrans extract and pumpkin seed protein peptide is osmanthus fragrans extract:pumpkin seed protein peptide=1:(0.2-8).The present application is improved vascular senility composition by osmanthus fragrans extract and pumpkin seed protein peptide collocation, can effectively inhibit angiotensin II induced vasoconstriction, enhance cardiac output, prevent zebra fish heart structure and function damage, while also can enhance blood flow velocity, reduce vascular injury, from multidimensional synergistic prevention vascular senility formation.

A handheld device configured to lower the core body temperature of a human individual by applying an external interface possessing surfaces cooled by an internally contained endothermic reaction to the glabrous skin of the individual's hands, feet, or face. An outer casing includes an interior chamber having multiple rupturable inner compartments, where at least some of these rupturable inner compartments include reactant chemicals. The rupturable inner compartments are configured to rupture upon application of user-generated mechanical force, thus releasing the reactant chemicals into the interior chamber of the outer casing. These reactant chemicals are chosen to produce an endothermic reaction that cools glabrous skin of the user at configured temperatures that reduce vasoconstriction.

The invention belongs to the technical field of food biology, and particularly provides Yanbian cattle blood-derived ACE (angiotensin converting enzyme) inhibitory peptide as well as a preparation method and application thereof, and the ACE inhibitory peptide is derived from Yanbian cattle blood and comprises an amino acid sequence as shown in SEQ.ID.NO.1-4. The docking energy of the ACE inhibitory peptide provided by the invention and a receptor ACE is (-0.54) kcal / mol, (-9.411) kcal / mol, (-9.206) kcal / mol and (-11.179) kcal / mol respectively. The ACE inhibitory peptide provided by the invention can promote release of endothelial cell NO, protect cells and reduce vasoconstriction, and also can play a role in reducing blood pressure by reducing secretion of endothelial cell ET-1. Therefore, the ACE inhibitory peptide obtained by the invention can be applied to food or medicines, and has important significance on the development of novel antihypertensive products.

The invention discloses a radial artery compressor, and relates to the technical field of medical instruments. The cold compress bandage comprises a bandage body, the outer wall of the bandage body is sleeved with a supporting block, the outer arc face of the supporting block is fixedly connected with a pressure meter, the pressing end of the pressure meter is fixedly connected with an air bag, the inner arc and the outer arc of the supporting block are provided with cold compress modules used for cold and heat adjustment, and the inner wall of one end of the bandage body is provided with a first hook-and-loop fastener. A second hook-and-loop fastener is arranged on the outer wall of the other end of the bandage body, the end, located on the second hook-and-loop fastener, of the bandage body is sleeved with a pressing plate, the outer wall of the pressing plate is fixedly connected with a circular ring, and the inner wall of the circular ring is in threaded connection with a threaded rod. The purposes of promoting vasoconstriction through cold compress, stopping bleeding and relieving pain are achieved, and meanwhile skin injury caused by too low cold compress temperature is avoided.

The present disclosure relates to antiperspirant cream composition that contains water, an antiperspirant material, an alpha-hydroxycarboxylic acid, an oil agent, a structuring agent and optionally caffeine or a xanthine derivative that has vasoconstrictive effects. The antiperspirant cream composition may be applied to a human's external skin in need or odor and perspiration control such as the user's axilla, pudendum, feet, chest, abdomen, thigh, and buttock.

A system includes a camera configured to acquire an image of an eye of a patient prior to a treatment of the eye with laser radiation, and a controller configured to, by processing the image, compute a constriction measure indicating an extent to which blood vessels of the eye were constricted by an α2 agonist, and in response to the constriction measure passing a predefined threshold, output an indication that the blood vessels were sufficiently constricted by the α2 agonist. Other embodiments are also described.