603 results about "Irritability" patented technology

A once-a-day oral milnacipran modified release formulation has been developed. The formulation comprises an extended release dosage unit (optionally containing the immediate release portion) coated with delayed release coating. The milnacipran composition, when administered orally, first passes through the stomach releasing from zero to less than 10% of the total milnacipran dose and then enters the intestines where drug is released slowly over an extended period of time. The release profile is characterized by a 0.05-4 hours lag time period during which less than 10% of the total milnacipran dose is released followed by a slow or extended release of the remaining drug over a defined period of time. The composition provides in vivo drug plasma levels characterized by Tmax at 4-10 hours and an approximately linear drop-off thereafter and Cmax below 3000 ng / ml, preferably below 2000 ng / ml, and most preferably below 1000 ng / ml. The composition allows milnacipran to be delivered over approximately 24 hours, when administered to a patient in need, resulting in diminished incidence or decreased intensity of common milnacipran side effects such as sleep disturbance, nausea, vomiting, headache, tremulousness, anxiety, panic attacks, palpitations, urinary retention, orthostatic hypotension, diaphoresis, chest pain, rash, weight gain, back pain, constipation, vertigo, increased sweating, agitation, hot flushes, tremors, fatigue, somnolence, dyspepsia, dysoria, nervousness, dry mouth, abdominal pain, irritability, and insomnia.

The present invent relates to sustained release and long residing ophthalmic formulation having thermosensitivity, mucoadhesiveness, hydro gel properties and small particle size. The said formulation comprises of micelle solution of random block co-polymer having a hydrophobic component and a hydrophilic component of general formula -(X+Y+Z-)m, wherein m is an integer greater than 2 X is a monomer which will provide hydrogel formation properties of the co-polymer to reduce the irritability of the eye and is selected from vinyl group of compounds Y is a monomer which will provide thermosensitivity properties of the co-polymer having a general formula R1-R2N-(C=O)-CH=CH2, R1=a proton or CnH2n+1 in which n may have the value from 3 to 6 and R2=alkyl group having chain length of C3 to C6 Z is a monomer which will provide mucoadhesiveness and pH-sensitivity properties to the co-polymer and is selected from acrylate based monomers at least one hydrophobic drug with the said block co-polymer solution; The invention also provides a process of preparing said formulation.

Improved hard surface cleaning compositions having an acidic pH, providing good removal of soap scum stains, and further feature low levels of irritability to the user. The compositions comprise about 0.1-10% by weight of an acid sequestrant constituent; about 0.1-10% by weight of a mixture of hydrophobic and hydrophilic solvents; about 0.001-1% by weight of a single constituent which exhibits both anionic surfactant and hydrotrope properties; about 0-20% by weight of one or more optional constituents; the balance to 100% by weight of water, wherein the aqueous hard surface cleaning composition exhibits a pH of 7 or less, especially a pH of about 5 or less. Although acidic, the improved hard surface cleaning compositions feature low irritability to the eyes and skin of consumers. The compositions also provide disinfecting effects.

The invention relates to a preparation method for enzyme laundry detergent. At present, most detergent in the market is prepared from chemical raw materials, skin irritation, irritability and pruritus are caused, the detergent has certain toxicity, environment is polluted severely, and health of people is harmed. The enzyme laundry detergent is prepared by organically combining natural active ingredients AES, oligose, chitosan, maltase, alkyl glycoside, enzyme, perfume, alcohol ethoxylates, salt, tartaric acid, glutamic acid, acetic acid, sodium butyrate and water. The enzyme laundry detergent has a biodegradation property, decomposes dirty marks automatically, removes various stubborn dirty marks, has the quick-acting and whitening effects, and can carry out sterilization and resist static electricity, harm to clothes and skin is avoided, and the clothes are kept shining and bright.

A medical device capable of delivering automatic rate-adjusting pacing therapies is provided having an adjustable upper rate limit responsive to an indication of myocardial irritability. The device, which may be embodied as a pacemaker, a pacemaker / cardioverter / defibrillator, or the like, responds to the detection of an arrhythmia as an indicator of myocardial irritability by adjusting an upper rate limit. The adjusted upper rate limit is applied as the maximum allowable pacing rate during delivery of any pacing therapies previously defined as “long-term” pacing therapies.

A once-a-day oral milnacipran pulsatile release composition has been developed that releases the drug in spaced apart “pulses”. The dosage forms are comprised of first, second and optional third dosage units, with each dosage unit having a different drug release profile. This dosage form provides in vivo drug plasma levels characterized by Cmax below 3000 ng / ml, preferably below 2000 ng / ml, and most preferably below 1000 ng / ml. The composition provides pulsatile release of milnacipran to produce a therapeutic effect over approximately 24 hours, when administered to a patient in need, resulting in diminished incidence or decreased intensity of common milnacipran side effects such as sleep disturbance, nausea, vomiting, headache, tremulousness, anxiety, panic attacks, palpitations, urinary retention, orthostatic hypotension, diaphoresis, chest pain, rash, weight gain, back pain, constipation, vertigo, increased sweating, agitation, hot flushes, tremors, fatigue, somnolence, dyspepsia, dysoria, nervousness, dry mouth, abdominal pain, irritability, and insomnia.

The methods and compositions of the present invention are directed to the treatment or amelioration of muscle cramps using a composition that includes one or more TRPV1 channel activators, and / or one or more TRPA1 channel activators, and / or one or more ASIC channel activators.

The invention discloses health-care medicinal granules capable of relieving mental pressure and resisting depression. The medicinal granules mainly comprises the following nutritional ingredients: Inca Inchi oil, Inca Inchi polypeptide, plantain powder, soybean polypeptide, L-theanine, passionflower, kendir, licorice root, kudzu root, schisandra fruit extract, deep sea fish oil, tryptophan, tyrosine, folic acid and the like. The method comprises the following steps: carrying out cold pressing and enzymolysis, evenly mixing according to parts by weight, adding emulsifier glycerol monostearate,homogenizing and carrying out spray drying. The nutritional medicinal granules disclosed by the invention have good mouthfeel, and has favorable action on improving depressed people with irritability, great mood fluctuations, obvious energy reduction, causeless continuous fatigue, insomnia, early sleep, hypersomnia, and concentration difficulty or plummet. Compared with products which can only relieve pressure and resist depression or western medicines with side effect, the nutritional medicinal granules have obvious advantages, are a novel health-care solid beverage, and have wide market development and application prospects.

Modified or extended release formulations containing mesalamine compounds and associated methods are disclosed and described. In some aspects, such formulations may be substantially bioequivalent to known FDA approved mesalamine formulations such as PENTASA®.

The invention relates to a feed additive capable of improving irritability resistance of weaning piglets, as well as preparation and application of the feed additive. The feed additive comprises a composite active ingredient and carrier matrixes, wherein the composite active ingredient comprises the following components in parts by weight: 80-110 parts of glutamine, 30-50 parts of arginine, 40-60 parts of taurine, 80-100 parts of yeast nucleotide, 10-30 parts of vitamin B6, 30-60 parts of vitamin E, 30-60 parts of vitamin C, 10-30 parts of selenium yeast, 50-90 parts of calcium formate, 80-110 parts of sodium butyrate and 80-130 parts of citric acid; during preparation, the components and the carrier matrixes are uniformly mixed; when the feed additive is applied, on the basis of a daily feed formula for piglets, the feed additive, accounting for 0.5-2% of the total mass of the daily feed, is added. Compared with the prior art, the feed additive is capable of reducing adverse impact of irritability on follow-on production property and intestinal health of weaning piglets, improving daily gain and feed conversion rate of weaning piglets, reducing diarrhea rate and death rate of weaning piglets and strengthening adaptive capacity of weaning piglet to a new environment.

A kit that is useful for relieving humans, and in particular infants, from discomfort is disclosed. Examples of such discomfort include fever, pain, congestion, skin irritation, and irritability. The kit includes an inner container having a plurality of compartments and at least one product for comforting humans packed in one of the compartments. Optionally, the inner container may be placed inside of an outer container.

The invention relates to a neo-gambogic acid SLN (solid lipid nanoparticle) and a preparation method thereof. The neo-gambogic acid SLN comprises a therapeutically effective amount of neo-gambogic acid, medicinal phosphatide, a surfactant and a lipid material. In the invention, the neo-gambogic acid is prepared into SLNs (solid lipid nanoparticles), thereby improving the solubility of the neo-gambogic acid, reducing the irritability, improving the bioavailability, and prolonging the action time of medicaments in a human body, in addition, the neo-gambogic acid SLNs can be gathered partially in the human body so as to play the targeted action of the SLNs and exert the anti-cancer therapeutic action of the SLNs better.

The invention discloses a composition with a skin whitening effect, and application thereof to cosmetics. The composition is prepared from the following ingredients in percentage by mass: 0.01 percent to 10 percent of 1-methylhydantoin-2-imide, 0.01 percent to 20 percent of nicotinamide, 0.01 percent to 20 percent of thyme extracts, 0.01 percent to 20 percent of orange peel extracts, 0.001 to 0.5 percent of fullerenes and the balance auxiliary materials and water. The composition has the advantages that the composition is safe and achieves the skin whitening effect; the irritability is low; free radicals can be effectively cleared away; efficient oxidation resistance is realized; the composition with the skin whitening effect is provided; the composition has different action mechanisms of inhibiting the tyrosinase activity, resisting oxidization, clearing away free radicals, brightening skin, holding moisture, accelerating the metabolism function of skin cells, and the like; the composition acts on the epidermal layer, the horny layer and the corium layer, so that the synergistic skin whitening effect is achieved; the irritation and the irritability are low.

The invention discloses an artificial breeding method for siganus oramin. Siganus canaliculatus and Siganus fuscesens are common fish stocks of Siganus, the physiological characters, reproductive habits and the breeding methods of the Siganus canaliculatus and Sigauns fuscesens are more similar, the problems that the source and domestication are difficult, newly hatched individuals are small in body size, the death rate caused by strong irritability of larva is high, a systematic artificial breeding technique is in shortage, the breeding offspring seeds are mainly from natural seedlings captured from ocean, and the like exist in the artificial breeding process. The artificial breeding method adopts the technical measures of parent fish culturing, cultivation, artificial spawning and incubation, larva cultivation pool preparation, cultivation water quality conditioning, staged bait feeding and juvenile fish transportation, so that the industrialization production of parent fish supply and seedling culture is realized, and the technical problems of artificial spawning and incubation of parent fish, selection and enrichment of larvae bait, water quality regulation and control, larva transportation and the like in the artificial breeding process of Siganus canaliculatus and Siganus fuscesens are systemically solved. The spawning rate of the cultivated parent fish can reach more than 65 percent, the average spawning fertility rate can reach more than 85 percent, and the survival rate of artificial breeding is 10.7 percent-27 percent.

The invention relates to compound quaternary ammonium salt disinfectant, which comprises dodecyldimethylbenzylammonium serving as a germicide, a double long-chain quaternary ammonium salt with high interference resistance and a synergist. The main technical characteristics of the compound quaternary ammonium salt disinfectant is the adoption of the high-safety mild and nonirritating poly(quaternary ammonium salt) which is formed by grafting C11 to C18 long-chain alkyl on the surface of an amino-terminated hyperbranched quaternary ammonium salt compound. The disinfectant can quickly kill board-spectrum fungi, saccharomycetes, mould, Escherichia coli, Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa, virus and the like; with disinfection concentration, the disinfectant is low in toxicity and irritability; being noncorrosive, the disinfectant avoids corroding pipes made of stainless steel, copper, aluminum and the like; and the disinfectant has high biodegradability, avoids polluting the environment and meets requirements for environment protection. The disinfectant can be used for disinfecting surfaces of common objects and disinfecting food processing equipment, cotton and chemical fiber textiles, skin, adhesive films and the like.

The invention discloses a breeding method of pigs, and relates to the technical field of pig breeding. The breeding method comprises a) a breast feeding period, b) a weaning period, c) a growth period, and d) a fattening period; particularly, a 10-day weaning method is adopted in the weaning period of piglets, namely the piglets are fed with a mixture of artificial milk and a commercially available sucking pig feed according to a weight ratio of 9:1 in the first day, and then are fed with a mixture of the artificial milk and the commercially available sucking pig feed according to a weight ratio of 8:2 in the second day, and so on, then one part of breast milk is reduced every day, one part of the sucking pig feed is increased every day, and the piglets are weaned in the tenth day and are only fed with the full sucking pig feed, therefore, weaning irritability of the piglets is avoided; and meanwhile, the pigs are fed with targeted feeds according to nutrients needed for growth in all periods of the pigs, and are vaccinated with different vaccines, so that the growth of the pigs is accelerated, the quality of pork can be guaranteed, and the health of eaters will not be influenced.

The invention relates to an ultrasound micro-needle composite transdermal drug delivery device which comprises an ultrasound transdermal drug delivery system and a porous micro-needle transdermal drug delivery system. The ultrasound transdermal drug delivery system comprises an ultrasonator, a control mechanism and an ultrasonic wave transmission dielectric layer arranged on the outer side of an end plate of a shell; the porous micro-needle transdermal drug delivery system comprises a drug storage pool, a liquid inlet pipe, a miniature peristaltic pump, a liquid outlet pipe, a drug inlet pool and poly-p-xylylene thin film, a plurality of micro needles are arranged on the poly-p-xylylene thin film, one end of each micro needle is communicated with the drug inlet pool, and the other end of each micro needle is used for being in contact with the skin for drug delivery. The ultrasound micro-needle composite transdermal drug delivery device solves the technical problems that irritabilities of patients are prone to being caused by an existing transdermal drug delivery device, the existing transdermal drug delivery device is low in drug delivery speed and poor in drug delivery effect, and the lengths of the micro needles cannot be adjusted when the existing transdermal drug delivery device acts on different parts of the human body so that the existing transdermal drug delivery device is limited in application range; the ultrasound micro-needle composite transdermal drug delivery device is high in drug delivery speed, good in drug delivery effect and suitable for application and popularization.

The invention discloses a blood-enriching skin-caring jelly for women. Needed raw materials comprise crystal sugar, yellow wine, citric acid, honey, nisin, donkey-hide glue, Chinese angelica, Chinese wolfberry, astragalus, red jujube, tuber of multiflower knotweed, black sesame, fruit grains and peach blossom. The product has sweet taste, is convenient to eat, has strong aroma, integrates the efficacies of various components into a whole, has the advantages of enriching blood and tonifying qi, beautifying face and caring skin, delaying senility, strengthening resistance and the like, is a superior nourishing product, has no toxic or side effect or unpleasant odor, and has apparent effects on the treatment of symptoms such as sallow complexion, dry hair, dry skin, chloasma, constipation, abnormal menstruation, dysmenorrhea, cold hands and feet, weak four limbs, insomnia, paramenia, upset irritability, insomnia and the like caused by deficiency of both qi and blood.

The invention discloses shampoo capable of strengthening hair and nourishing hair. The shampoo capable of strengthening hair and nourishing hair comprises the following components: sodium laureth sulphate, sodium lauroyl sarcosine, aloe barbadensis leaf juice, citric acid, cocamide MEA, cocamidopropyl betaine, pyridoxine HCl, honey, tea seed oil, panthenol (provitamin B5), dipotassium glycyrrhizinate, hydrolyzed gadidae fishskin protein, tocopherol acetate (vitamin E), ligusticum wallichii extract, fleece-flower root extract, ginseng extract, polygonum multiflorum extract, tremella extract, vanillyl butyl ether, essence, preservative and water. The shampoo capable of strengthening hair and nourishing hair contains multiple nutritional components, can nourish scalp and remove scrap, has multiple effects of toughening beautiful hair, strengthening hair, promoting hair growth, preventing hair loss, and the like, is obvious in effect, can not produce negative effect and has low irritability, and eyes can be open when the shampoo disclosed by the invention is used.

The invention relates to a brain-building intelligence-reinforcing pill for treating brain exhaustion psychosis. Polygonum multiflorum, jujube kernel, polygala tenuifolia, schisandra chinensis, radix ophiopogonis, fushen, rehmannia root and fructus ligustri lucidi in the prescription aim at the symptoms of liver and kidney deficiency, deficiency fire disturbance, cardiac-splenic lesion, worry beyond measurement, damage to brain nerves, insomnia, lightness in the head, headache, palpitation, dysphoria, irritability, soreness and weakness of waist and knees, reddened yellow thin-furred tongue and slow and thin pulse. Patients suffering from brain empty and brain failure are weak in body, are irritated, overstrain their brains, liver and kidney deficiency and hyperactivity happen accordingly. Therefore, the patients suffer from lightness in the head, headache, lower yin deficiency and upper yang deficiency, feels ill at ease, suffers from palpitation and insomnia and are agitated and irritated. Therefore, the pill is utilized to nourish heat and spleen, enabling the patients to calm down and nourish the deficiency of the brain through an external source. Angelica sinensis, radix paeoniae alba and radix bupleuri in the prescription are used for smoothing liver, promoting qi, nourishing blood and liver, adjusting qi and smoothing emotions. The pill with traditional Chinese medicines in full prescription has the functions of smoothing liver and qi, promoting blood circulation, removing stasis, nourishing blood, enriching the blood, enabling qi and blood to be vigorous and tranquilizing and allaying excitement and has the advantages of nourishing and flourishing the brain. Various mental diseases cannot reappear after the patients are cured.

The invention discloses a method, system and terminal equipment for irritability early warning. The method comprises the steps that a patient's irritability information is collected; irritability factor data is called to be compared with the patient's irritability information, and a comparison result is obtained; and contents of irritability warning are judged according to the comparison result. Through recording of information such as onset time, the onset position, irritability symptoms and allergens of the patient, onset reasons and rules of the patient are summarized; technological assistance methods are used for reminding and warning of the patient from multiple dimensions such as the time, the position, and an allergen type; the irritability morbidity of the patient is reduced; and the patient's life quality is improved.

The invention relates to a method for improving sensory quality of tobacco leaves by using a compound enzymic preparation. According to the method, the compound enzymic preparation containing cellulose, pectinase, protease, FeSO4, biacetyl, citric acid, trisodium citrate and water is used to degrade celluloses and pectin in tobacco leaves. The compound enzymic preparation has the advantages of reducing the content of harmful ingredients in cigarette smoke such as phenol, HCN, BaP and NNK, reducing the irritability and strength of the cigarette smoke, enriching fragrance, and lightening miscellaneous gas, so that the cigarette smoke is relatively fine, and the sensory quality of the tobacco leaves is improved.

The compound Chlorhexidinum acetate spray is prepared with Chlorhexidinum acetate, borneol, menthol, ethanol, essence and distilled water as material. Daily use and clinical observation shows that the spray may be used widely in treating various skin pruritus caused by different causes, including insect bite, irritability, eczema, etc. The present invention is one kind of safe, reliable, externally applied medicine with determined treating effect and low cost.

The invention discloses a special biological disinfectant for toothbrush and a preparation method thereof. The disinfectant is characterized by comprising the following components by weight: 1.0-2.0% of carboxymethyl chitosan, 2.0-4.0% of seaweed polysaccharide, 6.0-8.0% of bactericidal peptide, 1.5-3.5% of mucopeptide-N-acetylmuramoylhydrolase, a proper amount of essence and the balance of purified water. The special biological disinfectant for toothbrush provided by the invention has the advantages of wide bactericidal spectrum, good stability, no toxicity, no stimulation, no corrosion, no irritability, no color, no odor and no side effect, can kill parasitic pathogenic bacteria on the toothbrush, and causes no corrosion to the toothbrush.

Modified or extended release formulations containing mesalamine compounds and associated methods are disclosed and described. In some aspects, such formulations may be substantially bioequivalent to known FDA approved mesalamine formulations such as PENTASA®.

The invention discloses a bendazac lysine eye drops with reduced irritability, its preparation method and application, wherein the eye drop is prepared from bendazac lysine, thickening agent, buffering agent, preservative agent, isotonic agent, substance for reducing eye drop pungency and water for injection.

The invention discloses anti-hair-loss and itching-relieving translucent shampoo and a preparation method thereof and belongs to the technical field of processing of daily cosmetics. The shampoo comprises components in parts by weight as follows: 10-15 parts of APG (alkyl polyglucoside), 5-10 parts of an anionic surfactant, 3-8 parts of a zwitterionic surfactant, 1-5 parts of an amino acid moisturizer, 1-5 parts of glycerol, 1-5 parts of polymeric quaternary ammonium salt, 0.1-0.5 parts of citric acid, 0.1-0.5 parts of EDTA (ethylene diamine tetraacetic acid), 0.5-2.0 parts of sodium chloride, 0.1-2 parts of tea extracts, 0.1-1 part of tea tree oil, 0.1-1 part of coriander oil, 0.1-1 part of star anise oil, 0.1-.2 parts of fresh ginger juice, 0.01-0.3 parts of essence and 40-80 parts of deionized water. The coriander oil and others are added, so that the shampoo has high sterilization, anti-inflammation and antioxidation functions and good antidandruff and antipruritic functions; the environment-friendly and mild surfactants with low irritability are selected, silicone oil or guar gum is not added, pore clogging can be relieved, hair loss is reduced, and the prepared shampoo is translucent.

The invention discloses a Chinese medicinal micro-ecological preparation for inhibiting piglet bacterial dysentery and a preparation method thereof. The Chinese medicinal micro-ecological preparation is prepared by adding an extracting solution of Chinese medicines into a mixed bacterial liquid of lactobacillus, saccharomycete and bacillus subtilis and performing anaerobic fermentation in a hermetic way, wherein the Chinese medicines comprise the following components in parts by weight: 6-15 parts of Chinese pulsatilla root, 5-10 parts of ash bark, 5-15 parts of baikal skullcap root and 5-10 parts of amur corktree bark. The Chinese medicinal micro-ecological preparation disclosed by the invention has the advantages that: (1) when Chinese medicinal herbs are used together with prebiotics during animal production, a synergic action is realized, and the effects of enhancing mechanism immunity, inhibiting harmful bacteria and the like are achieved; (2) the curative effect is definite, the prevention and control effects on piglet bacterial dysentery are remarkable, and the curative effect on piglet bacterial dysentery is particularly remarkable; (3) a mixed feeding method is adopted, convenience is brought to use, and the irritability of livestock is lowered; and (4) the Chinese medicinal micro-ecological preparation is free from toxic and side effects, and is safe and reliable.