8 results about "Gambogic acid" patented technology

The invention discloses a ginsenoside Rg3-gambogic acid co-assembled nanoparticle which is prepared by co-assembling ginsenoside Rg3 and gambogic acid, and a preparation method of the ginsenoside Rg3-gambogic acid co-assembled nanoparticle. The ginsenoside Rg3-gambogic acid co-assembled nanoparticles can effectively increase the delivery rate of drugs, improve the solubility of gambogic acid, have a good anti-cancer effect, and have a better effect compared with a single drug of the same dosage. Meanwhile, the ginsenoside Rg3-gambogic acid co-assembled nanoparticles disclosed by the invention realize carrier-free pure drug self-delivery, and the delivery efficiency is improved. The invention discloses an application of the ginsenoside Rg3-gambogic acid co-assembled nanoparticles in preparation of an anti-tumor drug, and further discloses a preparation method of the ginsenoside Rg3-gambogic acid co-assembled nanoparticles.

The invention belongs to the technical field of medicines, and particularly relates to a microneedle patch for disguising a macrophage cell membrane and a preparation method of the microneedle patch. Degradable high polymer material nano-particles camouflaged by the macrophage membrane are embedded in a microneedle array of the microneedle patch camouflaged by the macrophage membrane, and the degradable high polymer material nano-particles camouflaged by the macrophage membrane are wrapped with gambogic acid and oleic acid functionalized cerium dioxide nano-particles. Nanoparticles of the microneedle patch jointly load gambogic acid and oleic acid functionalized cerium dioxide, through microneedle transdermal drug delivery, active targeting of the drug to the liver is achieved by using natural inflammatory taxis of a macrophage membrane, the anti-inflammatory effect of gambogic acid and the anti-oxidation effect of cerium dioxide are synergistically exerted, polarization of macrophages is adjusted, and the anti-inflammatory effect of the drug on the liver is achieved. Therefore, the liver injury caused by the septic shock is treated.

The invention discloses a preparation method and application of esterase sensitive gambogic acid self-assembled micelle nanoparticles. Gambogic acid and poloxamer 188 are used as raw materials of the self-assembled micelle nanoparticle, and GA and P188 form an ester bond through esterification reaction, so that a gambogic acid self-assembled micelle nanoparticle precursor is formed. The gambogic acid micelle nanoparticles can be formed through self-assembly in an aqueous solution, the particle size is uniform, the average particle size is about 58 nm, the polydispersity index is 0.203, and it is indicated that the micelle nanoparticles have good monodispersity. In-vitro release studies show that the prepared gambogic acid self-assembled micelle nanoparticles have esterase responsiveness and are expected to realize targeted release of gambogic acid at tumor sites, and the anti-tumor effect is improved. The preparation method of the gambogic acid self-assembled micelle nanoparticle GA-P188 provided by the invention is simple in operation steps, relatively low in cost and good in tumor inhibition effect, and can have relatively high industrialization prospects.

The invention belongs to the field of plant planting, and particularly relates to a method for improving saline-alkaline tolerance of plants. According to the specific technical scheme, the method for helping seed germination under saline-alkali stress comprises the following steps: soaking seeds in dihydrocoumarin, gambogic acid, 2-aminonicotinic acid or triptolide, or applying dihydrocoumarin, gambogic acid, 2-aminonicotinic acid or triptolide to the vicinity of a plant root system to be treated. It is found for the first time that 2-aminonicotinic acid, gambogic acid, dihydrocoumarin and triptolide have the capability of enhancing the saline-alkaline tolerance of plants at low concentration, so that the 2-aminonicotinic acid, gambogic acid, dihydrocoumarin and triptolide have the potential as plant growth regulators or plant biostimulants.

The invention discloses a nanoparticle of ferritin co-carrying IR808 and gambogic acid with the surface modified with tumor penetrating peptide and a preparation method and application thereof, the nanoparticle comprises a carrier, and the carrier is ferritin; the targeting part is a tumor penetrating peptide covalently modified on the surface of ferritin, and a connection site is a ferritin surface sulfydryl; the carried objects are a photosensitizer IR808 and gambogic acid, and the carried objects are loaded in the inner cavity of the cage-shaped structure of the ferritin. Compared with non-modified ferritin, the RGE-ferriprotein-IR808-gambogic acid nano particle provided by the invention has the advantages that the tumor cell uptake capability is enhanced; compared with the chemotherapy or phototherapy of a ferritin single-loading drug, the anti-tumor effect of the ferritin co-loading two drugs is better, the chemotherapy and the photothermal / photodynamic therapy have a synergistic effect, and the ferritin co-loading two drugs have a wide application prospect in the aspect of tumor treatment.

The application belongs to the technical field of biological medicine, and particularly relates to application of a flavone small molecule compound in preparation of a drug for regulating WDR1 and / or treating leukemia. The flavone small molecule compound comprises Gambogic amide, Morellic acid, Flavopiridol hydrochloride, Gambogic Acid and / or Methylophiopogonanone B. The application research finds that the flavone small molecule compound such as Gambogic amide can effectively inhibit the activity of acute myeloid leukemia stem cells, and does not damage normal hematopoietic stem cells. The flavone small molecule compound is combined with WDR1 protein specifically expressed in the leukemia stem cells, induces cytoskeleton depolymerization, and further promotes the occurrence of leukemia stem cell apoptosis. The application provides a new direction for prevention and treatment of AML.

The invention belongs to the technical field of biological medicines, and particularly relates to application of gambogic acid combined with imatinib in preparation of a medicine for treating gastrointestinal stromal tumor. The gambogic acid and the imatinib are jointly applied to treatment of the gastrointestinal stromal tumor, and compared with an existing single imatinib treatment scheme, the gambogic acid and the imatinib can form a synergistic anti-tumor effect, so that the sensitivity of gastrointestinal stromal tumor cells to the imatinib is effectively improved, the problem that the drug effect is insufficient possibly existing when a single drug is used is solved, and the curative effect of the gastrointestinal stromal tumor is improved. And the overall treatment effect is improved. The gambogic acid and imatinib are combined to further inhibit the activity and proliferation of gastrointestinal stromal tumor cells and induce tumor cell apoptosis, so that the gastrointestinal stromal tumor resisting effect is enhanced. Therefore, the invention provides a new strategy and choice for the drug treatment of gastrointestinal stromal tumor, and has important clinical application value.

This application relates to the preparation and application of a gambogeylic acid formulation targeting malignant tumors. It employs a three-layer structure: the core is a gambogeylic acid-black phosphorus quantum dot complex, possessing both chemotherapy and photothermal therapy functions; the middle layer consists of cryogenically frozen NK92 MI cell-derived nanovesicles, providing natural immune targeting and killing capabilities; the outer shell is a hyaluronic acid chelate, enabling active targeting and pH / photothermal responsive drug release. The core of its preparation method lies in using coaxial electrospray technology to form the three layers in one step, resulting in a highly efficient process and good formulation stability. This formulation can achieve synergistic photothermal-chemo-immunotherapy and simultaneously possesses near-infrared fluorescence and photoacoustic multimodal imaging capabilities, effectively solving the problems of poor targeting, significant toxic side effects, and lack of real-time monitoring associated with traditional chemotherapy. It demonstrates significant advantages and application potential in the precision treatment and diagnosis of solid tumors.