384results about How to "Less irritating" patented technology

The invention discloses burdock root fermentation liquor as well as a preparation method and application thereof in cosmetics, and belongs to the technical field of cosmetics. The preparation method provided by the invention comprises the following steps: inoculating a culture medium with pseudoalteromonas or schizosaccharomyces pombe for activation to obtain a seed solution; the seed solution is inoculated into a fermentation medium, burdock root powder is added, the adding concentration of the burdock root powder in the fermentation medium is 45-55 g / L, then fermentation is conducted to the end point, and after-treatment is conducted, the burdock root fermentation liquor is obtained. The burdock root fermentation liquor prepared by the preparation method disclosed by the invention has excellent anti-oxidation effect, anti-allergy soothing effect and tightening effect, also has certain healing promoting and repairing functions, is safe, non-toxic and small in irritation, and can be used for preparing anti-oxidation, anti-allergy and soothing cosmetic raw materials.

The invention discloses pseudomonas TB392 and application thereof in degradation of pectin and generation of flavor substances in tobacco leaves, and belongs to the technical field of biology. The strain is preserved in the China General Microbiological Culture Collection Center on October 16, 2024, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.32230. The strain can produce pectinase at high yield, has the capability of reducing nicotine, can degrade macromolecular compounds such as carotenoid, starch, pectin, cellulose and the like in tobacco leaves, and can remarkably improve the content of flavor substances in the tobacco leaves. After the strain or the prepared microbial agent is applied to tobacco leaves, the quality of the tobacco leaves can be improved, and the use value of the tobacco leaves is improved.

The invention relates to the technical field of cosmetics, and particularly discloses repairing essence oil and a preparation method thereof. The essence oil comprises a humectant, a conditioning and repairing agent, an emollient, an antioxidant, a preservative, an aromatic and an auxiliary agent. The skin moisturizer, the conditioning and repairing agent, the emollient and other active ingredients in the formula all adopt natural plant extracts as main ingredients, and are supplemented with common, safe, non-toxic and small-irritation auxiliaries, so that the essence oil product with obvious advantages in the aspect of repairing is prepared, and meanwhile, the moisturizing property is good.

The invention belongs to the technical field of cosmetics, and particularly relates to an emulsifier-free face cream and a preparation method thereof. The face cream provided by the invention is mainly prepared from the following components in parts by weight: 50 to 67 parts of water, 10 to 40 parts of grease, 5 to 25 parts of a humectant, 0.2 to 0.7 part of a thickening agent, 0.5 part of a preservative and 0.1 to 0.4 part of a pH (Potential of Hydrogen) regulator. According to the face cream provided by the invention, the system stability can be kept without adding an emulsifier, the requirement on the compatibility of the used grease is low, the high stability of the system can be kept only by adjusting the melting point of the oil phase, and the grease proportion of the system can reach 40%. The system is extremely low in irritation, more friendly to sensitive skin, capable of rapidly dissolving water in use, free of sticky feeling after being smeared and capable of providing strong moistening feeling after being absorbed. Compared with a traditional emulsification system, the preparation process has a relatively wide requirement on a homogenizing temperature range, and the temperature is kept above the melting point of an oil phase during homogenizing dispersion.

The invention provides a hydroxytyrosol supramolecular compound and a preparation method and application thereof, and belongs to the technical field of cosmetics and biological medicine, the supramolecular compound comprises the following chemical components by mass: 0.01-10% of hydroxytyrosol, 2-45% of an amino acid compound, 2-20% of alpha hydroxy acid, 2-30% of urea, and 15-92% of water. The supramolecular compound can promote transdermal delivery of hydroxytyrosol and maintain the biological activity of hydroxytyrosol, shows high biocompatibility, and can be applied to product development in the antibacterial field, the regeneration field and the anti-aging field.

The invention belongs to the field of medicines, and discloses a crystal of difloxacin and a salt-based compound thereof, the grain size of the crystal is 200nm-10mu m, and the crystal is of a sheet structure. The crystal provided by the invention has the particle size of 200nm-10mu m, is of a sheet structure, can stably exist in water in a suspension form, has the advantages of long acting time and small irritation, does not block a needle head, and can be prepared into preparations with various concentrations. Meanwhile, the invention also discloses a preparation method of the crystal.

The invention provides a hair and bath cleaning product, which is prepared from the following ingredients in parts by weight: 0.3 to 1.0 part of cationic surface active agents, 9.0 to 15.3 parts of ampholytic surface active agents and 0.6 to 3.6 parts of anionic surface active agents. The hair and bath cleaning product can effectively control the generation of flocculation in the dilution process, the product keeps clear and stable when diluted by 10-10.4 times, flocculation starts to occur when the dilution ratio is greater than or equal to 10.5, and the hair and bath cleaning product is particularly suitable for being directly used after being diluted. The product has the effects of washing hair and bathing, is not added with antibacterial components, also has a good antibacterial effect, and can avoid the breeding of bacteria in the use process of the diluent.

The invention discloses selenium disulfide shampoo with a good suspension effect and a preparation method of the selenium disulfide shampoo. The selenium disulfide shampoo comprises the following raw materials in percentage by weight: 0.05-1% of selenium disulfide particles; 0.2-6% of a high-molecular polymer capable of suspending selenium disulfide particles; 0.5 to 5% of a polyol; and 0.05%-0.1% of a chelating agent. The selenium disulfide shampoo has the advantage of being good in suspension effect, and the problems that in the using process of existing selenium disulfide shampoo, due to the fact that the dispersion uniformity and suspension stability of selenium disulfide in the shampoo are poor, the selenium disulfide is likely to be precipitated in a shampoo container, the concentration of the selenium disulfide before and after use is different, and the selenium disulfide cannot be precipitated in the shampoo container are solved. The treatment effect of the selenium disulfide shampoo on a patient is influenced.

The invention belongs to the field of medicines, and particularly relates to a difloxacin microcrystal suspension injection which comprises water and a difloxacin crystal existing in the water in a suspension state. The particle size of the difloxacin crystal is 200 nm to 10 [mu] m, and the difloxacin crystal is of a sheet structure. The particle size of the difloxacin crystal in the difloxacin microcrystalline suspension injection provided by the invention is 200nm-10mu m, the difloxacin crystal is of a sheet structure, the crystal can stably exist in a liquid carrier in a suspension form, and after being prepared into the injection, the difloxacin microcrystalline suspension injection has the advantages of long acting time, small irritation and no blockage of a needle tube, and can be prepared into preparations with various concentrations. Meanwhile, the invention also provides a preparation method of the suspension injection.

The invention relates to the technical field of skin care, and provides a composition with anti-photoaging and after-sun soothing effects as well as a preparation method and application thereof. The composition comprises the following components in parts by weight: 0.01-1 part of a trollius chinensis bunge extract, 0.01-1 part of a Chinese wolfberry fruit extract, 0.01-1 part of a poria cocos sclerotium extract and 0.5-10 parts of sutrandan, and active components of the sutrandan comprise a radix sophorae flavescentis extract, a tribulus terrestris fruit extract and a dogwood fruit extract. According to the composition, six specific plant extracts including the trollius chinensis bunge extract, the Chinese wolfberry fruit extract, the poria cocos sclerotium extract, the radix sophorae flavescentis extract, the tribulus terrestris fruit extract and the dogwood fruit extract are selected and compounded, and the multiple components have a synergistic effect, so that the prepared product has good light aging resistance and after-sun soothing effects at the same time; and the composition also has the advantages of small irritation and high safety.

The utility model provides a traditional Chinese medicine retention enema device for an enterostomy patient, and belongs to the technical field of medical instruments. The device comprises a liquid filling assembly and an antifouling assembly, the liquid filling assembly comprises an enema bag and an infusion tube, and the infusion tube is provided with a Murphy dropper and a flow regulator; the anti-fouling assembly comprises an ostomy bag, and the ostomy bag comprises a bag body and a base plate. A through hole is formed in the chassis; a mounting hole is formed in the bag body, and a sealing piece is arranged in the mounting hole in a matched mode. An insertion channel used for inserting an infusion tube is arranged in the sealing piece, and the tail end of the infusion tube enters the enterostomy through the insertion channel. The infusion tube is further sleeved with a flexible tube, one end of the flexible tube penetrates through the insertion channel of the sealing piece and extends into the enterostomy, and the other end of the flexible tube is arranged outside the sealing piece. And the other side of the fixed pressure plate is also connected with a chock plug. The device is simple to operate and convenient and quick to use; the ostomy bag is clean and transparent, and ostomy conditions are easy to observe; discharge is all in the ostomy bag, peculiar smell is small, pollution is avoided, and the comfort level of a patient is improved.

The invention discloses application of indobufen in preparation of a medicine for preventing and treating diseases induced by excessive ferroptosis, and particularly relates to the technical field of medicines. The invention relates to an application of indobufen in preparation of drugs for preventing and treating diseases induced by excessive ferroptosis by inhibiting ferroptosis. The indobufen is a ferroptosis inhibitor. The invention provides a new application of indobufen alone or in combination with other drugs in promoting wound healing. Cell and animal level experiments prove that the indobufen can inhibit the local ferroptosis level of the wound surface, so that the wound surface healing is obviously accelerated, and the indobufen has a good clinical application prospect.

The present invention relates to the technical field of cosmetics, and in particular to a hair dye composition for preventing hair breakage, hypoallergenic and repairing, and a preparation method and application thereof. The composition is composed of agent A and agent B in a mass ratio of 1:0.8-1.5. The raw materials of agent A are hydrogen peroxide, glycerol, thickener, cetearyl alcohol polyether, sodium stannate, hydroxyethylidene diphosphoric acid and water. The raw materials of agent B are: p-phenylenediamine, sodium sulfite, triethanolamine, urea, Polygonum multiflorum extract, Acorus calamus extract, Nepeta tenuifolia extract, chelating agent, ascorbate, preservative, keratin, trehalose, 4-amino-2-hydroxytoluene, polyquaternium salt, squalane, arbutin, allantoin, bisabolol, emulsifier, polyglutamic acid, octadecyl alcohol, wheat germ oil and water. The hair dye of the present invention has a good hair dyeing effect, and has hypoallergenicity, and also has a good effect of preventing hair breakage and repairing hair quality.

The invention relates to the technical field of cigarette manufacturing, and discloses cigarette filter stick forming paper containing bamboo ultrafine powder and a preparation method thereof, the cigarette filter stick forming paper comprises the following raw materials by mass: 40-60 parts of wood pulp cellulose, 0-35 parts of tobacco stem ultrafine powder, 10-30 parts of bamboo ultrafine powder, 20-30 parts of a modified calcium carbonate filler, 12-16 parts of essence and 1-6 parts of a cigarette paper additive; the modified calcium carbonate is obtained by compounding calcium carbonate with zeolite powder and then modifying with glyceryl triacetate. By means of the method, smoke can have the fresh and sweet fragrance of bamboos, the smoke is enriched, the smoke state and the fragrance style are improved, offensive odor and irritation of tobaccos are reduced, and the smoking quality of cigarettes is improved.

The invention discloses moisturizing, whitening and cutin-removing essence containing salicylic acid and a preparation method of the moisturizing, whitening and cutin-removing essence. The essence provided by the invention is prepared from the following components in percentage by mass: 0.5 to 2 percent of a skin conditioner I, 2 to 5 percent of a humectant I, 0.05 to 0.08 percent of a surfactant I, 0.05 to 1 percent of a humectant II, 0.2 to 1 percent of a humectant III, 0.3 to 0.5 percent of a surfactant II, 0.05 to 0.015 percent of a skin conditioner II, 0.05 to 0.015 percent of a skin conditioner III and the balance of water. The salicylic acid compound is introduced into the essence, so that the water solubility of salicylic acid is improved, the skin care effect of salicylic acid is facilitated, and the irritation caused by salicylic acid is reduced. Compared with the prior art, the moisturizing, whitening and cutin-removing essence containing salicylic acid prepared by the invention is safe and non-irritant, and has good moisturizing, whitening and cutin-removing effects.

The invention discloses a hand-care detergent as well as a preparation method and application thereof. The hand-care detergent comprises the following components: sodium fatty acid methyl ester sulfonate, sodium linear alkyl benzene sulfonate and sodium alcohol ether sulphate. The formula system of the hand-care detergent is in a low-irritation state, and the hand-care effect is achieved while the decontamination effect of the detergent is guaranteed.

The present invention provides the use of a toad oil cream in preparing a drug for treating dermatitis, and relates to the field of medical technology. The toad oil cream is composed of toad oil and a matrix, and the toad oil is prepared according to the method of Chinese invention patent application CN117126696 A, and the matrix is ​​composed of cetostearyl alcohol, glyceryl monostearate, liquid paraffin, dimethicone, propylparaben, carbomer, glycerol, potassium lauryl phosphate, hyaluronic acid, methylparaben, triethanolamine and water. The toad oil cream obtained by the present invention can reduce the irritation of toad oil to the skin, improve the spreadability of toad oil, show good therapeutic effects on atopic dermatitis and contact dermatitis, and can be used to treat dermatitis.

The invention belongs to the field of medicine preparations, and particularly relates to a local external medicine composition for treating alopecia, the medicine composition comprises at least one active component, and the medicine composition comprises the following components in percentage by weight: 1-10% w / w of minoxidil or salt thereof, 0-50% w / w of propylene glycol, 1-50% w / w of ethanol and 10-50% w / w of C3-C10 ether solvent, the total dosage of the propylene glycol and the ethanol is less than or equal to 50% w / w, and the total dosage of the propylene glycol and the ethanol is less than or equal to 50% w / w. The pharmaceutical composition at least has the following excellent characteristics: good curative effect, high drug solubility, high patient efficiency, quick response, few adverse reactions, low scalp irritation, good stability, easy use, no greasy feeling after use, good drug permeability, high bioavailability, few use times, good patient compliance and the like.

The present invention relates to the technical field of cosmetics, and in particular to a herbal hair loss prevention, hair growth, and hair darkening composition and a preparation method thereof. The present invention adopts Polygonum multiflorum, Elm bark, ginger, alfalfa, Gallnut, Lycium bark, and Hamamelis virginiana, which have hair loss prevention, hair growth, and hair darkening effects, to prepare a hair composition. The present invention optimizes the ratio of raw materials, enhances the matching effect of active ingredients, and makes the hair loss prevention, hair growth, and hair darkening effects of the composition better. At the same time, the present invention adopts hot water extraction and dissolution, composite bacteria combined fermentation, and ethanol aqueous solution extraction processes to increase the types of active ingredients and the concentration of active substances, enhance the efficacy of the medicine, and can further improve the hair loss prevention, hair growth, and hair darkening effects of the composition.

The invention discloses a water-oil two-phase microbead essence and a preparation method thereof, and relates to the technical field of cosmetics. Comprising the following raw materials in percentage by weight: 2wt%-5wt% of plant polysaccharide, 0.005 wt%-0.015 wt% of meso-tetramethyl-meso-tetra-p-aminophenyl calix [4] pyrrole, 0.5 wt%-1wt% of hyaluronic acid, 0.3 wt%-1wt% of fish collagen peptide, 0.1 wt%-3wt% of other plant extracts, 8wt%-15wt% of glycerol, 0.1 wt%-0.3 wt% of plant germ oil, 1wt%-4wt% of other vegetable fat, 0.1 wt%-0.3 wt% of hydroxypropyl beta-cyclodextrin, 0.3 wt%-0.5 wt% of ceramide and the balance of water. And the balance of deionized water. The water-oil two-phase microbead essence is high in stability, small in skin irritation and remarkable in whitening, moisturizing, anti-wrinkle and sunscreen effects.

The invention discloses a solid dispersion of beta-1, 3 / alpha-1, 3-glucan as well as a preparation method and application thereof, and belongs to the technical field of biology. The solid dispersion of beta-1, 3 / alpha-1, 3-glucan provided by the invention comprises beta-1, 3 / alpha-1, 3-glucan and polysaccharide, wherein the beta-1, 3 / alpha-1, 3-glucan and the polysaccharide are compounded to form the solid dispersion; the mass ratio of the beta-1, 3 / alpha-1, 3-glucan to the polysaccharide is 3: (1.5-3); the polysaccharide comprises one or more of curdlan, carrageenan and microcrystalline cellulose; the solid dispersion of beta-1, 3 / alpha-1, 3-glucan has lower viscosity and higher solubility in application, and the stability of a beverage can be effectively improved; and the preparation method is simple and easy to implement and suitable for industrial mass production, and the obtained solid dispersion does not contain a surfactant, is safer and has smaller irritation.

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

The invention discloses a solid dispersion of beta-1, 3 / alpha-1, 3-glucan as well as a preparation method and application thereof, and belongs to the technical field of biology. The solid dispersion of beta-1, 3 / alpha-1, 3-glucan provided by the invention comprises beta-1, 3 / alpha-1, 3-glucan and phosphate, wherein the beta-1, 3 / alpha-1, 3-glucan and the phosphate are compounded to form the solid dispersion; the mass ratio of the beta-1, 3 / alpha-1, 3-glucan to the phosphate is 3: (2-5); the solid dispersion of beta-1, 3 / alpha-1, 3-glucan has lower viscosity and higher solubility in application, and the stability of a beverage can be effectively improved; and the preparation method is simple and easy to implement and suitable for industrial mass production, and the obtained solid dispersion does not contain a surfactant, is safer and has smaller irritation.

A formula of the adapalene gel comprises glabridin serving as a high humectant, glycerol and butanediol, and further comprises propylene glycol, a carbomer homopolymer type C, poloxamer, disodium ethylene diamine tetraacetate, methyl p-hydroxybenzoate, a pH regulator and purified water. The content of glabridin is 1%-3%, preferably 2%. During preparation, the carbomer homopolymer C is dispersed in a uniform dispersion of propylene glycol, butanediol and glycerol under stirring, and then is hydrated with purified water under stirring. The adapalene mask has the advantages that the formula and the preparation method are reasonable in design, irritation to the skin can be effectively reduced on the premise that the treatment effect of adapalene is guaranteed, and the skin is helped to keep moisture.

The invention discloses a preparation method of oxilafluorine, which comprises the following step: carrying out alkylation, deprotection, hydroxyethylation and salt forming reaction on a compound (II) to prepare the oxilafluorine as shown in a formula (I). The method has the advantages of low raw material cost, simple process operation, environmental friendliness, high reaction yield, high product purity and wide industrial prospect.

The present invention belongs to the technical field of daily cosmetics, and specifically relates to a makeup remover cream composition and a preparation method thereof, wherein the makeup remover cream composition comprises 60-80 parts of component A, 10-25 parts of component B, and 0.2-1 parts of component C by mass, wherein the component A comprises vegetable oil, grease, and synthetic wax; the component B comprises trehalose lipid, yucca saponin extract, and nonionic surfactant, polyol, and water. The nonionic surfactant is PEG-7 glyceryl cocoate: PEG-20 glyceryl triisostearate: PEG-3 glyceryl isostearate in a mass ratio of 2.5-5 parts: 2.5-5 parts: 0.5-1 parts. The makeup remover cream prepared by the present invention by compounding a plurality of formula ingredients with biosurfactants, yucca extracts, and nonionic surfactants can efficiently remove water-based and oily makeup while being gentle and non-irritating.

The invention discloses skin antibacterial powder and a preparation method thereof, and relates to the technical field of skin antibacterial products. Comprising the following components in parts by weight: 1-3 parts of chlorhexidine acetate nanocrystals, 5-8 parts of radix sophorae flavescentis powder, 6-10 parts of cortex phellodendri powder, 3-6 parts of cortex dictamni powder, 2-4 parts of sail powder, 1-3 parts of tea polyphenol / chitosan nanoparticles, 15-25 parts of other Chinese herbal medicine extracts, 0.8-1.5 parts of borneol powder and 0.6-1 part of plant polysaccharide. The skin antibacterial powder is good in antibacterial activity, good in antibacterial durability, low in toxic and side effects and remarkable in wound repairing effect.

The invention discloses a whitening anti-oxidation composition which comprises pterostilbene and phenylethyl resorcinol, and the weight ratio of the pterostilbene to the phenylethyl resorcinol is 1: (0.6-1.5). According to the whitening anti-oxidation composition, the anti-oxidation and whitening effects can be remarkably improved, the anti-oxidation and whitening effects are good, and meanwhile the stability is high. According to the invention, lipidosome is adopted for coating, so that the formed cosmetic raw material has better stability and is not easy to yellow in stability detection, and the content retention effect of pterostilbene and phenylethyl resorcinol is better. The composition is applied to whitening and anti-oxidation products and is small in irritation and high in use stability, the whitening and anti-oxidation effects are further improved, the active oxygen removal rate reaches 68% or above, and the melanin inhibition rate reaches 88% or above.

The invention provides a tooth film. The tooth film comprises a stripping layer, a whitening layer and a backing layer, the stripping layer and the backing layer are polyolefin films; the whitening layer is prepared from the following components in parts by weight: 10 to 20 parts of a modified whitening agent, 15 to 35 parts of a thickening agent, 5 to 10 parts of a humectant, 0.3 to 0.8 part of a stabilizer, 0.1 to 0.5 part of a bacteriostatic agent, 1 to 3 parts of a modified anti-allergic agent and 0.5 to 1.5 parts of a pH regulator. The tooth film prepared by the invention has a good whitening effect, and is non-irritant and good in stability.

The invention provides a high-strength high-toughness low-smoke halogen-free flame-retardant rat-proof cable sheath material and a preparation method thereof, and the cable sheath material comprises the following raw materials: 80.0-100.0 parts of a polymer matrix, 80.0-100.0 parts of an inorganic flame retardant, a functional biomass rat-proof agent, 2.0-4.0 parts of a vulcanizing agent and 0.5-1.0 part of a vulcanization accelerator, wherein the functional biomass rat-proof agent is prepared from bio-based dihydric alcohol, bio-based diisocyanate and capsaicin through a one-pot method, and the cable sheath material is obtained by adding the raw materials into an extruder in proportion for melting, blending and extruding and then carrying out cooling curing, traction, grain-sized dicing and drying. The obtained cable sheath material has high strength, high toughness, high flame retardance and long-acting rat-proof performance, and meets the requirements of high mechanical property, flame retardance and long-acting rat-proof performance of materials in the field of cables.