44 results about "Neuroregulation" patented technology

A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The parameter curve includes inflections that correspond to changes in the fluid parameter. Based on the inflections, the system can determine the body lumen size or the neuromodulation parameter. Other embodiments are also described and claimed.

The invention discloses a cerebral cortex stimulation central nervous regulation system and method based on a pulse magnetic coil, and the system comprises a pulse magnetic stimulation module, a neural signal collection module, a central control module and a man-machine interaction module, and is additionally provided with a three-dimensional positioning module and a multi-level safety monitoring module. The pulse magnetic stimulation module generates a focused pulse magnetic field, the neural signal acquisition module acquires multi-brain-region electric signals, and the central control module dynamically regulates stimulation parameters after analyzing the signals to form closed-loop regulation; the three-dimensional positioning module ensures accurate positioning of the coil, the safety monitoring module monitors parameters in real time and triggers emergency protection, and the man-machine interaction module realizes convenient operation and data management. According to the method, adjustment is completed through initialization, signal acquisition and analysis, precise stimulation, positioning adjustment and safety monitoring. The scheme is non-invasive, accurate, safe and suitable for nerve research and disease treatment, the regulation effect and use safety are improved, and development of the nerve regulation technology is promoted.

Embodiments of present disclosure provide systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for administering deep brain stimulation (DBS), and for evaluating the efficacy and efficiency of DBS for the treatment of neurological conditions (e.g., Parkinson's disease).

The invention provides a device for treating at least one of rhinitis, congestion, and / or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, coughing, sneezing, nasal or throat irritation and itching, and difficulty sleeping. The device includes a shaft, a retractable and expandable end effector, and handle, that, as a whole, provide a high level of precise control and feedback to an operator during a procedure. The shaft includes an electrode array provided along a length thereof configured to deliver energy to specific target sites within the nasal passage and nasal cavity in conjunction with neuromodulation provided by the end effector.

The invention provides an essential oil composition for improving sleep quality, and relates to the field of plant essential oils, the essential oil composition comprises the following raw materials by mass: 15-20% of rose geranium essential oil, 15-20% of organic lavender essential oil, 30-40% of organic Provenus lavender essential oil, 15-20% of organic Atlantic cedar essential oil, and 10-15% of West Indian sandalwood essential oil. The essential oil composition is used for improving sleep, chemical components of different essential oils complement and cooperate, and a composite effect is achieved on multiple aspects of central nervous system sedation, emotion stabilization, endocrine balance, vegetative nerve regulation and the like.

Systems and methods for controlling autonomic symptoms or side effects via spinal cord stimulation are discussed. An exemplary neuromodulation system comprises an electrostimulator to provide spinal cord stimulation (SCS) to a neural target, a user interface device to receive a user input including an autonomic symptom and affected anatomy, and a controller circuit to determine or adjust a stimulation parameter based at least on the autonomic symptoms and the affected anatomy. Spinal cord stimulation can be delivered in accordance with the determined or adjusted stimulation parameter to alleviate the autonomic symptom, or to treat or alleviate autonomic disorders.

Provided are methods for treating depression and depression-related conditions by combining administration of pharmacologic agents and neuromodulation induced by transcranial electrical stimulation.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For examples, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

Featured are intravaginal devices and electrical stimulation devices, systems, thereof, and methods of using the devices and systems thereof to observe pelvic floor movements in order to diagnose, treat, or prevent urinary and fecal incontinence disorders (e.g., urge incontinence) and their accompanying symptoms or to diagnose and / or improve the efficacy of neuromodulation therapy.

The invention is suitable for the technical field of biological medicine, and provides an active composition for relieving fatigue and application of the active composition. The composition is prepared from a silkworm chrysalis-derived mitochondrial repair peptide, a chickpea-derived neuromodulation peptide, a haematococcus pluvialis-derived phagocytosis peptide, a phosphatidylcholine-lipoic acid conjugate, a whey protein-chitosan copolymer and an ergothioneine-selenium compound in a synergistic manner. Through the synergistic effect of four mechanisms of energy metabolism activation, endocrine balance, mitochondrial autophagy repair and oxidative stress removal, physiological fatigue and stress fatigue are effectively and synchronously relieved. After targeted modification, the utilization rate of macamides is remarkably increased, and the composition can remarkably prolong exercise tolerance, reduce cortisol level, promote GABA synthesis, recover mitochondrial function and greatly shorten fatigue recovery time.

Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed.

The invention relates to the technical field of pharmaceutical compositions, in particular to an atomization composition and application thereof. An aerosolized composition comprising: A) an MSC-derived active ingredient selected from any one or a combination of (i) MSC exosomes / extracellular vesicles, (ii) an MSC conditioned culture solution concentrate, (iii) an MSC lysate, (iv) an MSC-derived soluble factor, (v) an immobilized / embedded protected MSC or fragment thereof; b) ergothioneine (EGT) or a pharmaceutically acceptable salt thereof; and C) a pharmaceutically acceptable carrier / buffer system making it suitable for aerosol inhalation administration. The exosome is combined with ergothioneine, and the effectiveness of sleep improvement is remarkably improved through mechanism synergy of nerve regulation and cell protection; the introduction of the atomization drug delivery technology breaks through the limitation of the traditional therapy from multiple dimensions of non-invasiveness, accurate delivery, individualized treatment, accessibility and the like, so that wider crowds (including special crowds) can safely, conveniently and efficiently receive treatment.

The present disclosure is directed to a bio-feedback sensor in combination with AI and ML that can be implemented to optimize neuromodulation parameters for the management of a medical condition such a type II diabetes. The bio-feedback obtained by the sensors is optimized by the ML tools to predict and recommend the upregulation or downregulating the neuroregulators to modulate treatment. The algorithms could also learn to sense a life-threating pathological state, or bio-chemical imbalance, and in the case of diabetes a life-threating low blood sugar level the system overrides to stimulate the target fibers that control organs to regulate blood glucose levels.

The invention relates to the technical field of artificial intelligence, and provides a multi-modal perception nerve regulation method and device, and the method comprises the steps: obtaining a regulation target of a user and a current psychological state portrait obtained based on the current multi-modal physiological data; on the basis of the current psychological state portrait, the previous psychological state portrait and an adjustment reward function constructed based on expert knowledge corresponding to the adjustment target, a previous adjustment reward is obtained through calculation; and inputting the current psychological state portrait, the adjustment target and the previous adjustment reward into a neuro-adjustment feedback strategy model to obtain a current adjustment strategy output by the neuro-adjustment feedback strategy model. According to the method provided by the invention, closed-loop intelligent decision-making under multi-modal perception and expert knowledge guidance is realized, the clinical effectiveness and safety of a feedback strategy are ensured, and further based on an adjustment strategy capable of dynamically adapting to the state change of a user, highly personalized, accurate and efficient nerve adjustment is realized.

The utility model relates to medical equipment technical field, concretely for based on patient active trigger and multimode feedback's upright tilt experiment safety control system, including patient trigger module, operator control module, collaborative feedback control module and tilt bed actuating mechanism. The patient can through wireless handheld button active trigger tilt bed lay flat, and button is equipped with long press identification, vibration feedback and low power prompt function. Control module according to patient signal, operator response and vital sign monitoring result, according to preset priority logic execution fast or slow lay flat, and support graded early warning and countdown interaction. The system is also provided with emergency stop rope and identity verification mechanism, and the operation safety is improved. The system can be widely applied to the tilt test scene such as neuroregulatory syncope screening, postural hypotension diagnosis, has the advantages of responding in time, high safety, good man-machine cooperation.

A neuromodulation device for functional rehabilitation and pain therapy (1, 100) is described, comprising a housing body (8, 108) and a housing cover (6, 106). within the housing body (8, 108), at least one electronic plate (7) being positioned, whereby the neuromodulation device for functional rehabilitation and pain therapy (1, 100), the electronic plate (7) comprising at least one control plate (71) equipped with at least one microcontroller for modulation function management, at least one actuator plate (72) equipped with at least one converter and an H-bridge, and at least one Wi-Fi module for connection with at least one sensor (14, 140) in order to forward data to an Artificial Intelligence module (201) and to at least one server (202).A stimulation and control system for functional rehabilitation therapy and pain therapy is also described, which is capable of collecting biomechanical data from the patient. This data is used for processing and calculations that assist a control subsystem in direct communication with the neuromodulation device for functional rehabilitation and pain therapy, enabling patient monitoring and adjustments of the neuromodulation device during therapy.

The application discloses a pet nutrition composition based on intestinal-brain axis regulation and application thereof, and the composition comprises 5-20% of probiotics, 10-25% of prebiotics, 2-10% of neurotransmitter precursors, 5-15% of anti-inflammatory and neurotrophic factors, 1-10% of plant extracts and the rest of carriers. The application remolds intestinal microecology by the synergy of probiotics and prebiotics, promotes the synthesis of 5-hydroxytryptamine and dopamine by neurotransmitter precursors, exerts the neuroprotective and anti-inflammatory effects by omega-3 fatty acids, vitamin B group and magnesium elements, realizes the anti-anxiety and tranquilizing effects by L-theanine, chamomile and lavender extracts, and forms a regulation link of multi-target point synergistic intervention of intestinal-brain axis. According to animal experiment verification, the application can significantly improve the anxiety behavior of pets, improve the content of fecal short-chain fatty acids, remodel the intestinal flora structure, and realize the synergistic effect of 'intestinal health-nerve regulation-behavior improvement'.

Described herein are various implementations of systems and methods for determining likelihood of a patient favorably responding to a neuromodulation procedure based on a quantitative or objective score or determination based on a plurality of indicators of pain (e.g., chronic low back pain stemming from one or more vertebral bodies or vertebral endplates of a patient). The systems and methods may involve application of artificial intelligence techniques (e.g., trained algorithms, machine learning or deep learning algorithms, and / or trained neural networks).

The invention belongs to the technical field of large health food, and discloses a composition for synergistically improving sleep based on neuromodulation and liver protection and application of the composition. The synergistic sleep improvement composition based on nerve regulation and liver protection comprises a nerve calming module and a liver protection module, sleep improvement is achieved through the synergistic effect of the nerve calming module and the liver protection module, the nerve calming module comprises spina date seed peptide, gamma-aminobutyric acid (GABA) and tea leaf theanine, and the liver protection module comprises gamma-aminobutyric acid (GABA) and tea leaf theanine. The liver protection module comprises sea-buckthorn powder (sea-buckthorn peptide) and glutathione-rich yeast, and the composition regulates the redox homeostasis of nervous centralis and the organism through multiple targets, and particularly realizes synergistic sleep improvement by protecting the liver function.

In some examples, a neuromodulation catheter includes an elongate body extending along a longitudinal axis, at least one therapy delivery element, and at least one reinforcement wire. The at least one therapy delivery element may be disposed on the expandable portion of the elongate body. The expandable portion may be configured to transition from a relatively low profile configuration to an expanded deployed configuration. The at least one reinforcement wire comprises a shape memory material and extends at least partially along the expandable portion.

The invention relates to the technical field of feed compositions, in particular to a feed composition for enhancing anti-stress ability of mice, which comprises a basic nutrition system and an anti-stress function system, the basic nutrition system comprises cereals, a protein source, a fat source, minerals and a vitamin premix; the anti-stress function system comprises immunoregulation polysaccharide, an organic selenium source and a neuroregulation component; the immunoregulation polysaccharide is selected from at least one of astragalus polysaccharide, codonopsis pilosula polysaccharide and lycium barbarum polysaccharide; the organic selenium source is selected from at least one of selenium yeast, selenized carrageenan and selenium-enriched yeast; the neuroregulation component is selected from at least one of gamma-aminobutyric acid, taurine and theanine. By constructing a ternary synergistic system of the immunomodulatory component, the organic selenium source and the neuromodulation component, a three-dimensional anti-stress mechanism of immunological enhancement, antioxidant protection and neuroendocrine regulation is realized, and multiple damage of stress to a mouse body is relieved from the source.

The invention discloses an insomnia comprehensive treatment method based on copper needle scraping therapy and auricular point pasting and pressing, and belongs to the technical field of traditional Chinese medicine external treatment methods. A three-order four-dimensional synergistic theory and practice framework is constructed, and through three sequentially progressive stages of a dredging sleep promoting stage, a balance consolidation stage and a steady state reconstruction stage, the sleep promoting stage, the balance consolidation stage and the steady state reconstruction stage are combined; smooth transition from strong intervention to steady state maintenance is realized in the time dimension; on the action level, copper needle scraping focuses on the overall conditioning of clearing and activating the channels and collaterals from outside to inside, and auricular point pasting focuses on targeted and continuous viscera and nerve regulation. And the treatment target, frequency, part and manipulation strength of each stage are definitely defined, and an intelligent dialectical system and a standard operation guide are matched, so that excessive dependence on personal experience of an operator is reduced, and the scheme is easy to learn, popularize and apply in primary medical institutions and has good repeatability.

Provided are methods for treating depression and depression-related conditions by combining administration of pharmacologic agents and neuromodulation induced by transcranial electrical stimulation.

The invention provides systems, devices, and methods for alleviating symptoms associated with a condition in a sinonasal cavity of a patient, such as sinonasal inflammatory disease, wherein such symptoms may include nasal congestion, facial pain and pressure, rhinorrhea and post-nasal drip. A neuromodulation device of the present invention includes a wearable or implantable oral appliance having one or more energy delivering elements strategically positioned along a surface thereof for delivery of therapeutic energy. The one or more energy delivering elements are positioned such that, upon the appliance being worn or implanted, the energy delivering elements become aligned with, and able deliver energy to, one or more target sites within the patient's oral cavity to thereby provide targeted stimulation of specific nerves to thereby alleviate symptoms.

Embodiments of a method for treating a patient suffering from chronic pain are described. A source location of chronic pain in a patient is first identified. A regional anaesthetic is then used to temporarily block selected nerves to confirm the source location and identify a target nerve. An electrode array of a neuromodulation apparatus is then implanted in the patient over the target nerve, such as just under the stratum corneum, and the neuromodulation apparatus is then used to stimulate the electrode array to create a long term conduction block that provides persistent pain relief to the patient.

The present application relates to a kind of brain deep electric stimulation equipment capable of realizing burst stimulation mode, the electric stimulation equipment includes brain deep stimulation unit and brain deep stimulation electrode, and they are connected by in-vivo lead wire.Wherein, brain deep stimulation unit is configured to be able to make brain deep stimulation electrode at adjustable stimulation parameter burst stimulation mode to implement the deep brain stimulation neuroregulation of target target point.Therein, the stimulation signal of burst stimulation mode can be adaptively adjusted according to the different electrophysiological characteristics of target target point one or more of group frequency, intra-group frequency and the number of sine waves in single stimulation period.

A system for selecting therapy parameters for a neurostimulation system associated with a brain includes a device configured to sense biosignal activity from the brain and an optimizer. The optimizer is configured to select a target region of the brain for neuromodulation therapy, which target region minimizes the difference between real biosignals captured by the device and modeled biosignals. The optimizer is further configured to determine stimulation settings for neuromodulation therapy, which stimulation settings result in a modeled electrical characteristic of stimulation at a target region that satisfies a criterion.

Methods and systems for improving medical conditions by delivering a focused ultrasound signal to target sites of the autonomic nervous system. The focused ultrasound signal can have a mechanical index of between about 0.1 to about 5.0 and / or an acoustic pressure of between about 0.1 MPa to about 2.5 MPa. The medical condition can comprise chronic or refractory rhinitis, chronic rhinosinusitis, autonomic instability / autonomic dysfunction, functional gastrointestinal disorders, inflammatory disorders, immune disorders (including improving cancer and infections by neuromodulation of immune function), complex regional pain syndrome, post-traumatic stress disorder (PTSD), anxiety and anxiety-associated disorders, autism, fibromyalgia, uterine function, metabolic disorder, urinary incontinence or binge eating.

This invention discloses a zinc-quercetin nanocomposite, its preparation method, and its pharmaceutical applications, belonging to the field of bionanomaterials technology. This nanoparticle employs a carrier-free self-assembly strategy, directly forming a structurally stable nanocomposite by combining the natural flavonoid quercetin with zinc ions through metal-organic coordination bonds. This technology effectively overcomes the inherent defects of poor water solubility and low bioavailability of quercetin monomers, resulting in a nanocomposite with good water solubility and physiological stability. Simultaneously, zinc ions, as a key trace element for neuroregulation, can intervene in pain transmission pathways to alleviate pain; quercetin exerts a long-lasting anti-inflammatory and analgesic effect by continuously scavenging reactive oxygen species and inhibiting the release of inflammatory factors in damaged nerves or inflammatory sites. The two work synergistically in the lesion microenvironment, achieving the prevention and efficient, safe treatment of chronic pain. The preparation process is extremely simple, requiring no complex carriers, and has broad prospects for clinical translation and application.

Disclosed herein is a system and method for implementing a personalized ultrasound neuromodulation system and methods with neural sensing of personalized electrophysiological data, guiding ultrasound targeting and dosage using such personalized data. Specific ultrasound transducer solutions are provided for various neural targets that enable the low-intensity focused ultrasound to modulate the central nervous system and peripheral nervous systems to treat a variety of neurological and mental disorders. A portable ultrasound console device, a wearable guiding apparatus and a compact solution for effectively and safely enabling point-of-care neuromodulation, e.g., home healthcare, are provided. Further methods for ultrasound waveform customization are also described to improve effectiveness of ultrasound neuromodulation.