96 results about "Neuroregulation" patented technology

Systems, devices, and methods for neurostimulation using a combination of implantable and external devices to treat pain are disclosed.

A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The parameter curve includes inflections that correspond to changes in the fluid parameter. Based on the inflections, the system can determine the body lumen size or the neuromodulation parameter. Other embodiments are also described and claimed.

The present invention describes an artificial intelligence (AI) enabled electroencephalography (EEG) system that integrates Pathway Hierarchical Adaptive Referencing (PHAR) for localized signal detection, large language models (LLMs) for automated EEG reporting, and Internet of Medical Things (IoMT) connectivity for adaptive neuromodulation control. The system can also deliver transcranial electrical stimulation (tES) pulses and function as an electrical impedance tomography (EIT) system. PHAR employs a multi-layered multiplexer hierarchy and adaptive referencing topologies to optimize EEG signal acquisition and spatial resolution. LLM integration enables automated generation of human-readable EEG reports. IoMT connectivity allows closed-loop neuromodulation, where real-time EEG analysis guides the adjustment of stimulation parameters. The system can deliver tES pulses and perform EIT expands its functionality, allowing for targeted neuromodulation and impedance-based brain imaging. This integrated system revolutionizes EEG-based diagnostics, treatment, and research in neurology and neuroscience, offering a comprehensive and versatile tool for understanding and modulating brain function.

A combined neuromodulation and / or neurostimulation system for mitigating locomotor deficits of / or neuronal disorders, especially Parkinson's disease, said system comprises: at least one Deep Brain Stimulation System for providing Deep Brain Stimulation to brain tissue of a subject, at least one control unit, configured and adapted to provide stimulation data, at least one stimulation unit, operatively connected to the at least one control unit, the at least one stimulation unit being configured and adapted to deliver epidural electrical stimulation to the dorsal side of the spinal cord of said subject, and at least one implantable pulse generator, wherein the at least one stimulation unit includes one or more electrodes configured to be implanted epidurally, the one or more electrodes being operatively connected to the at least one IPG.

The invention discloses a VR emotion quantitative management method and system based on physical and psychological interaction, and relates to the field of psychotherapy, and the method comprises the steps: collecting the heart rate variability data, the electrodermal response data and the EEG alpha wave power data of a user in a resting state, and obtaining the EEG alpha wave power data of the user based on the heart rate variability data and the electrodermal response data; generating color, density and physical boundary parameters of the initial emotion energy field; and rendering a dynamic emotion energy field in the VR environment according to the initial emotion energy field parameters, and detecting the distance change between the user and the dynamic emotion energy field through a field density growth algorithm. According to the method, heart rate variability, electrodermal response and EEG alpha wave data are fused by adopting an S-shaped curve function to generate emotion energy field parameters, accurate mapping of physiological states and virtual environments is established, emotion recognition sensitivity is improved, treatment efficiency is improved, field density attenuation rate is dynamically controlled innovatively through parasympathetic nerve activation degree, and the treatment effect is improved. And the synergistic effect of behavior intervention and nerve regulation is realized.

The invention relates to an anti-fatigue refreshing functional chewing gum containing natural active ingredients, which relates to the technical field of food, and comprises a gum base, a natural sweetening agent and an active ingredient mixture, the mustard extract and coffee are innovatively combined to form a dual-channel nerve activation mechanism, the mustard extract realizes instant refreshing through a targeted oral trigeminal nerve TRPA1 ion channel, caffeine maintains continuous excitation through antagonism of a central adenosine receptor, and the space-time cooperation of the mustard extract and the coffee breaks through the limitation of a single path. Meanwhile, a rhodiola rosea extract, a sea-buckthorn extract, an American ginseng extract and astragalus polysaccharide are compounded, so that a triple anti-fatigue physiological barrier with functions of nerve regulation, oxidative stress inhibition and energy metabolism optimization is formed. In the preparation process, a microcapsule embedding technology is adopted to control slow release of mustard active ingredients, menthol flavor is combined to synergistically trigger TRP channel dual activation, and unification of efficacy and palatability is achieved.

The invention relates to a method and system for predicting post-induced hypotension of a patient, and belongs to the technical field of hypotension prediction.The method comprises the steps that original data reflecting the cardiovascular autonomic nerve regulation capacity of the patient is obtained; preprocessing the original data to obtain target data, and calculating a target pressure reflex sensitivity BRS and a target pressure reflex effective index BEI based on the target data and the same-direction change sequence of the continuous heartbeat; inputting the target pressure reflex sensitivity BRS, the target pressure reflex effective index BEI and the patient baseline data into a Logistic regression model to obtain a hypotension risk probability; and determining a hypotension risk level of the patient based on the hypotension risk probability and a preset threshold range. According to the method, the target pressure reflex sensitivity BRS and the target pressure reflex effective index BEI serve as predictive factors, so that the probability of predicting hypotension of a patient can be improved before the patient receives anesthesia induction.

Systems and methods for patient guided neuromodulation therapy are disclosed. An exemplary system comprises a processing system and a memory. The memory may store instructions executable by the processing system to receive a medication schedule from a patient associated with neuromodulation therapy. The instructions may be executable by the processing system to send queries related to symptoms and side effects experienced by the patient. The instructions may be executable by the processing system to determine a parameter for a period of time of medication efficacy. The instructions may be executable by the processing system to determine a change in the parameter for the period of time.

The invention discloses a cerebral cortex stimulation central nervous regulation system and method based on a pulse magnetic coil, and the system comprises a pulse magnetic stimulation module, a neural signal collection module, a central control module and a man-machine interaction module, and is additionally provided with a three-dimensional positioning module and a multi-level safety monitoring module. The pulse magnetic stimulation module generates a focused pulse magnetic field, the neural signal acquisition module acquires multi-brain-region electric signals, and the central control module dynamically regulates stimulation parameters after analyzing the signals to form closed-loop regulation; the three-dimensional positioning module ensures accurate positioning of the coil, the safety monitoring module monitors parameters in real time and triggers emergency protection, and the man-machine interaction module realizes convenient operation and data management. According to the method, adjustment is completed through initialization, signal acquisition and analysis, precise stimulation, positioning adjustment and safety monitoring. The scheme is non-invasive, accurate, safe and suitable for nerve research and disease treatment, the regulation effect and use safety are improved, and development of the nerve regulation technology is promoted.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

Embodiments of present disclosure provide systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for administering deep brain stimulation (DBS), and for evaluating the efficacy and efficiency of DBS for the treatment of neurological conditions (e.g., Parkinson's disease).

The invention provides albizia flower compound essential oil with sleep aiding and depression relieving functions and a preparation method of the albizia flower compound essential oil, and relates to the technical field of aromatherapy and natural product application. The compound essential oil takes an albizia flower low-temperature two-stage extract as a core carrier and is compounded with various functional essential oil components such as bitter orange leaf essential oil, FCF bergamot essential oil and Egypt nymphaea tetragona original essence, and the compound essential oil is prepared through three core innovations of albizia flower carrier synergistic technology, multi-channel nerve regulation design and safety strengthening design. The technical problems that existing sleep-aiding essential oil is single in effect and high in potential nerve irritation and the bioavailability of albizia flower flavonoid glycoside is low are solved. Experimental verification shows that the compound essential oil can shorten the sleep latency period by 52% and reduce the anxiety score by 47%, can cooperatively regulate the GABA energy system, 5-hydroxytryptamine secretion and hypothalamus-pituitary-adrenal axis through an olfaction-nerve reflex path, realizes efficient anxiety resistance, deep sleep promotion and emotion balance, and is suitable for people with various anxiety insomnia and emotional disorder.

The invention provides a device for treating at least one of rhinitis, congestion, and / or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, coughing, sneezing, nasal or throat irritation and itching, and difficulty sleeping. The device includes a shaft, a retractable and expandable end effector, and handle, that, as a whole, provide a high level of precise control and feedback to an operator during a procedure. The shaft includes an electrode array provided along a length thereof configured to deliver energy to specific target sites within the nasal passage and nasal cavity in conjunction with neuromodulation provided by the end effector.

The application provides a closed-loop neuroregulation method and system based on transcranial light, which comprises the following steps: obtaining scale data, brain blood oxygen information and brain electrical information of a target user, inputting the information into a pre-trained target brain function rehabilitation prediction model, outputting a brain function rehabilitation prediction result of the target user by the target brain function rehabilitation prediction model based on the information, and adjusting a light regulation scheme of the target user based on the brain function rehabilitation prediction result. Since the scale data, brain blood oxygen information and brain electrical information contain brain function information of the target user from multiple aspects, the target brain function rehabilitation prediction model obtains sufficient comprehensive input information, and can output an accurate brain function rehabilitation prediction result, thereby improving the accuracy of the light regulation scheme obtained based on the brain function rehabilitation prediction result, and further improving the gain of transcranial light regulation.

The invention provides an essential oil composition for improving sleep quality, and relates to the field of plant essential oils, the essential oil composition comprises the following raw materials by mass: 15-20% of rose geranium essential oil, 15-20% of organic lavender essential oil, 30-40% of organic Provenus lavender essential oil, 15-20% of organic Atlantic cedar essential oil, and 10-15% of West Indian sandalwood essential oil. The essential oil composition is used for improving sleep, chemical components of different essential oils complement and cooperate, and a composite effect is achieved on multiple aspects of central nervous system sedation, emotion stabilization, endocrine balance, vegetative nerve regulation and the like.

Systems and methods for controlling autonomic symptoms or side effects via spinal cord stimulation are discussed. An exemplary neuromodulation system comprises an electrostimulator to provide spinal cord stimulation (SCS) to a neural target, a user interface device to receive a user input including an autonomic symptom and affected anatomy, and a controller circuit to determine or adjust a stimulation parameter based at least on the autonomic symptoms and the affected anatomy. Spinal cord stimulation can be delivered in accordance with the determined or adjusted stimulation parameter to alleviate the autonomic symptom, or to treat or alleviate autonomic disorders.

A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and / or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and / or reverse the growth of a prostate gland or a prostate tumor.

Systems and methods for coordination of medication adjustment for neuromodulation therapy are disclosed. An exemplary system comprises a processing system. The processing system may receive medication data associated with administration of medication from a. patient in an absence of administering electrostimulation to the patient. The processing system may receive stimulation data, associated with administration of electrostimulation therapy to the patient while the patient is not being administered medication. The processing system may compare the medication data to the stimulation data to provide a comparison. The processing system may generate a medication schedule and an electrostimulation schedule based on the comparison to increase efficacy of therapy and minimize side effects.

Provided are methods for treating depression and depression-related conditions by combining administration of pharmacologic agents and neuromodulation induced by transcranial electrical stimulation.

A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For examples, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

The present invention relates to doses and dosing regimens of an NRG4 compound in the treatment of cardiovascular disease (CVD) related conditions, including heart failure (HF).

Featured are intravaginal devices and electrical stimulation devices, systems, thereof, and methods of using the devices and systems thereof to observe pelvic floor movements in order to diagnose, treat, or prevent urinary and fecal incontinence disorders (e.g., urge incontinence) and their accompanying symptoms or to diagnose and / or improve the efficacy of neuromodulation therapy.

Intraoral neuromodulation for the treatment clinical conditions such as, e.g., dysphagia, migraines, or speech problems can be achieved with a neuromodulation system that includes an intraoral neural stimulator, e.g., integrated into a wearable device to be positioned in the oral cavity, that is controlled based on one or more measured signals associated with an intraoral organ or nerve related to the clinical condition.

The invention is suitable for the technical field of biological medicine, and provides an active composition for relieving fatigue and application of the active composition. The composition is prepared from a silkworm chrysalis-derived mitochondrial repair peptide, a chickpea-derived neuromodulation peptide, a haematococcus pluvialis-derived phagocytosis peptide, a phosphatidylcholine-lipoic acid conjugate, a whey protein-chitosan copolymer and an ergothioneine-selenium compound in a synergistic manner. Through the synergistic effect of four mechanisms of energy metabolism activation, endocrine balance, mitochondrial autophagy repair and oxidative stress removal, physiological fatigue and stress fatigue are effectively and synchronously relieved. After targeted modification, the utilization rate of macamides is remarkably increased, and the composition can remarkably prolong exercise tolerance, reduce cortisol level, promote GABA synthesis, recover mitochondrial function and greatly shorten fatigue recovery time.

Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed.

The application provides a specific neurofeedback training system for improving anxiety based on multi-modal fusion, which forms specific electroencephalogram signals through the projection strategy of magnetoencephalogram signals to electroencephalogram, and is used for the regulation and improvement of anxiety emotion. The application belongs to the technical field of medical treatment, and comprises an electroencephalogram acquisition module, a real-time processing module and a visual feedback module which are connected with each other; a complete treatment closed loop from signal acquisition, signal processing, signal feedback and signal acquisition is realized. The application decodes and analyzes electroencephalogram signals in real time, extracts features, and uses a specific mapping model of multi-modal feature fusion to establish a specific electroencephalogram mapping signal reflecting the real-time activity of core brain regions related to emotion (such as amygdala), which has stronger spatial accuracy and symptom specificity; the specific mapping signal is applied to neurofeedback treatment, which can assist in formulating individualized and multi-course neuroregulation training, improving the anxiety emotion of users, and providing a non-invasive and convenient neuroregulation platform for users.

Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics. Digital data related to three-dimensional imaging of a target vessel and corresponding hemodynamic data are inputs for generating a computational fluid dynamics (CFD) model. The CFD model enables identification of one or more regions of the vessel suitable for neuromodulation therapy and / or identification of one or more regions of the vessel to be avoided during therapy. Systems of the present technology may include a neuromodulation catheter, a computing device that can generate and analyze the CFD model, and a user interface for displaying the vessel with markers for target regions and / or avoidance regions.

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

The invention relates to the technical field of pharmaceutical compositions, in particular to an atomization composition and application thereof. An aerosolized composition comprising: A) an MSC-derived active ingredient selected from any one or a combination of (i) MSC exosomes / extracellular vesicles, (ii) an MSC conditioned culture solution concentrate, (iii) an MSC lysate, (iv) an MSC-derived soluble factor, (v) an immobilized / embedded protected MSC or fragment thereof; b) ergothioneine (EGT) or a pharmaceutically acceptable salt thereof; and C) a pharmaceutically acceptable carrier / buffer system making it suitable for aerosol inhalation administration. The exosome is combined with ergothioneine, and the effectiveness of sleep improvement is remarkably improved through mechanism synergy of nerve regulation and cell protection; the introduction of the atomization drug delivery technology breaks through the limitation of the traditional therapy from multiple dimensions of non-invasiveness, accurate delivery, individualized treatment, accessibility and the like, so that wider crowds (including special crowds) can safely, conveniently and efficiently receive treatment.