139 results about "Neuroregulation" patented technology

Systems, devices, and methods for neurostimulation using a combination of implantable and external devices to treat pain are disclosed.

The invention belongs to the technical field of health-care products, and particularly relates to a formula helpful for improving sleep and a preparation method thereof. Comprising the following raw material components in parts by weight: 90-110 parts of spina date seed powder, 45-55 parts of casein hydrolysate peptide powder, 15-22 parts of gamma-aminobutyric acid, 18-22 parts of lucid ganoderma powder, 15-22 parts of lily powder, 18-20 parts of poria cocos powder, 12-15 parts of tea leaf theanine and 1-4 parts of lactobacillus plantarum JYLP-326. According to the formula for improving sleep provided by the invention, the limitation of an existing insomnia treatment means is broken through through a three-dimensional synergistic network of traditional Chinese medicines, probiotics and functional components, and the formula realizes systematic improvement on insomnia core symptoms through multi-channel synergy of nerve regulation, intestinal brain axis intervention and immune balance, namely rapid induction of sleep.

The invention discloses an electroencephalogram transformation simulation system and method for different brain states based on a Hopv model, and the electroencephalogram transformation simulation system constructs a virtual brain model by using an objective nonlinear dynamic model, carries out the quantitative description of the brain states, and achieves the accurate simulation of the transformation between different brain states and the prediction of a target spot. According to the method, the weighted phase lag index and the similarity of the network attributes of the weighted phase lag index are used as a parameter optimization target when the virtual brain signal is constructed, the electroencephalogram simulation level of the virtual signal is improved, and the target spot in the brain state transition process can be recognized and predicted by extracting the co-activation brain area of the co-activation mode and combining virtual stimulation. According to the method, a quantitative basis is provided for virtual brain model construction and brain state regulation and control, and an individualized nerve regulation and control strategy can be formulated.

A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The parameter curve includes inflections that correspond to changes in the fluid parameter. Based on the inflections, the system can determine the body lumen size or the neuromodulation parameter. Other embodiments are also described and claimed.

The present invention describes an artificial intelligence (AI) enabled electroencephalography (EEG) system that integrates Pathway Hierarchical Adaptive Referencing (PHAR) for localized signal detection, large language models (LLMs) for automated EEG reporting, and Internet of Medical Things (IoMT) connectivity for adaptive neuromodulation control. The system can also deliver transcranial electrical stimulation (tES) pulses and function as an electrical impedance tomography (EIT) system. PHAR employs a multi-layered multiplexer hierarchy and adaptive referencing topologies to optimize EEG signal acquisition and spatial resolution. LLM integration enables automated generation of human-readable EEG reports. IoMT connectivity allows closed-loop neuromodulation, where real-time EEG analysis guides the adjustment of stimulation parameters. The system can deliver tES pulses and perform EIT expands its functionality, allowing for targeted neuromodulation and impedance-based brain imaging. This integrated system revolutionizes EEG-based diagnostics, treatment, and research in neurology and neuroscience, offering a comprehensive and versatile tool for understanding and modulating brain function.

According to the neural regulation target positioning method and system based on magnetic resonance and electroencephalogram fusion and the focus brain tissue head model construction method based on deep learning, the individual brain structure can be accurately simulated, and a reliable basis is provided for subsequent analysis; according to the electroencephalogram source imaging method based on deep learning, a brain source can be effectively positioned from complex electroencephalogram signals; a target network accurate positioning method based on source imaging further locks and regulates a target spot and a target brain network. The combination of the three can give full play to the advantages of multi-modal data, achieves more accurate and efficient target spot and target network positioning by means of the powerful ability of deep learning, and provides powerful support for nerve disease diagnosis and treatment.

A combined neuromodulation and / or neurostimulation system for mitigating locomotor deficits of / or neuronal disorders, especially Parkinson's disease, said system comprises: at least one Deep Brain Stimulation System for providing Deep Brain Stimulation to brain tissue of a subject, at least one control unit, configured and adapted to provide stimulation data, at least one stimulation unit, operatively connected to the at least one control unit, the at least one stimulation unit being configured and adapted to deliver epidural electrical stimulation to the dorsal side of the spinal cord of said subject, and at least one implantable pulse generator, wherein the at least one stimulation unit includes one or more electrodes configured to be implanted epidurally, the one or more electrodes being operatively connected to the at least one IPG.

An example catheter includes an elongate shaft including a proximal portion and a distal portion including a neuromodulation element. The neuromodulation element includes a plurality of electrodes disposed along a length of an elongate structure and a bend between a first segment of the length of the elongate structure and second segment of the length of the elongate structure such that the second segment extends in a proximal direction from the bend.

The invention discloses a VR emotion quantitative management method and system based on physical and psychological interaction, and relates to the field of psychotherapy, and the method comprises the steps: collecting the heart rate variability data, the electrodermal response data and the EEG alpha wave power data of a user in a resting state, and obtaining the EEG alpha wave power data of the user based on the heart rate variability data and the electrodermal response data; generating color, density and physical boundary parameters of the initial emotion energy field; and rendering a dynamic emotion energy field in the VR environment according to the initial emotion energy field parameters, and detecting the distance change between the user and the dynamic emotion energy field through a field density growth algorithm. According to the method, heart rate variability, electrodermal response and EEG alpha wave data are fused by adopting an S-shaped curve function to generate emotion energy field parameters, accurate mapping of physiological states and virtual environments is established, emotion recognition sensitivity is improved, treatment efficiency is improved, field density attenuation rate is dynamically controlled innovatively through parasympathetic nerve activation degree, and the treatment effect is improved. And the synergistic effect of behavior intervention and nerve regulation is realized.

The invention relates to an anti-fatigue refreshing functional chewing gum containing natural active ingredients, which relates to the technical field of food, and comprises a gum base, a natural sweetening agent and an active ingredient mixture, the mustard extract and coffee are innovatively combined to form a dual-channel nerve activation mechanism, the mustard extract realizes instant refreshing through a targeted oral trigeminal nerve TRPA1 ion channel, caffeine maintains continuous excitation through antagonism of a central adenosine receptor, and the space-time cooperation of the mustard extract and the coffee breaks through the limitation of a single path. Meanwhile, a rhodiola rosea extract, a sea-buckthorn extract, an American ginseng extract and astragalus polysaccharide are compounded, so that a triple anti-fatigue physiological barrier with functions of nerve regulation, oxidative stress inhibition and energy metabolism optimization is formed. In the preparation process, a microcapsule embedding technology is adopted to control slow release of mustard active ingredients, menthol flavor is combined to synergistically trigger TRP channel dual activation, and unification of efficacy and palatability is achieved.

The invention discloses a self-adaptive closed-loop neural feedback system for improving anxiety based on individual specificity and an implementation method, and the system comprises a data collection and processing module, an open-loop control module and a self-adaptive negative feedback module, a complete treatment closed loop from signal acquisition and processing to open-loop control to adaptive negative feedback to signal acquisition and processing is realized; an individual fuzzy controller unit is combined with a traditional electroencephalogram neural feedback framework, the anxiety state of an individual is monitored and adjusted in real time, the task difficulty is accurately changed, and therefore the optimal anxiety intervention effect is rapidly achieved. According to the method, the self-adjusting ability of each individual within a period of time is reflected through iterative evaluation of the anxiety state of the individual, and the task difficulty is adjusted according to different individual characteristics, so that the individual is stimulated to play a higher potential; neural feedback training is carried out by applying the self-adaptive task difficulty, individualized and accurate multi-course nerve regulation training can be made in an auxiliary mode, and the anxiety emotion of an individual is improved.

The invention relates to a method and system for predicting post-induced hypotension of a patient, and belongs to the technical field of hypotension prediction.The method comprises the steps that original data reflecting the cardiovascular autonomic nerve regulation capacity of the patient is obtained; preprocessing the original data to obtain target data, and calculating a target pressure reflex sensitivity BRS and a target pressure reflex effective index BEI based on the target data and the same-direction change sequence of the continuous heartbeat; inputting the target pressure reflex sensitivity BRS, the target pressure reflex effective index BEI and the patient baseline data into a Logistic regression model to obtain a hypotension risk probability; and determining a hypotension risk level of the patient based on the hypotension risk probability and a preset threshold range. According to the method, the target pressure reflex sensitivity BRS and the target pressure reflex effective index BEI serve as predictive factors, so that the probability of predicting hypotension of a patient can be improved before the patient receives anesthesia induction.

Systems and methods for patient guided neuromodulation therapy are disclosed. An exemplary system comprises a processing system and a memory. The memory may store instructions executable by the processing system to receive a medication schedule from a patient associated with neuromodulation therapy. The instructions may be executable by the processing system to send queries related to symptoms and side effects experienced by the patient. The instructions may be executable by the processing system to determine a parameter for a period of time of medication efficacy. The instructions may be executable by the processing system to determine a change in the parameter for the period of time.

The invention discloses a cerebral cortex stimulation central nervous regulation system and method based on a pulse magnetic coil, and the system comprises a pulse magnetic stimulation module, a neural signal collection module, a central control module and a man-machine interaction module, and is additionally provided with a three-dimensional positioning module and a multi-level safety monitoring module. The pulse magnetic stimulation module generates a focused pulse magnetic field, the neural signal acquisition module acquires multi-brain-region electric signals, and the central control module dynamically regulates stimulation parameters after analyzing the signals to form closed-loop regulation; the three-dimensional positioning module ensures accurate positioning of the coil, the safety monitoring module monitors parameters in real time and triggers emergency protection, and the man-machine interaction module realizes convenient operation and data management. According to the method, adjustment is completed through initialization, signal acquisition and analysis, precise stimulation, positioning adjustment and safety monitoring. The scheme is non-invasive, accurate, safe and suitable for nerve research and disease treatment, the regulation effect and use safety are improved, and development of the nerve regulation technology is promoted.

Described herein are various implementations of systems and methods for treating back pain (e.g., chronic low back pain) caused by different (e.g., independent) sources of pain, such as pain originating or stemming from intervertebral discs, from vertebral endplates, and / or from intraosseous locations within one or more vertebral bodies. For example, methods for treating back pain (e.g., chronic low back pain) may involve both vertebral fusion (e.g., arthrodesis or spondylodesis to fuse adjacent vertebrae) and neuromodulation (for example, ablation of nerves within or surrounding one or more of the adjacent vertebrae). The neuromodulation may facilitate treatment of pain that is generated by insertion of fusion hardware.

The invention discloses a composition based on the synergistic effect of an SOD-LF covalent conjugate and neuromodulation and application of the composition in preparation of drugs for relieving anxiety and insomnia and improving sleep quality, and belongs to the technical field of biology. The preparation method comprises the following steps: preparing an SOD-LF covalent conjugate from lactoferrin and SOD; uniformly dispersing the SOD-LF covalent conjugate in a sodium alginate solution, spraying into a calcium chloride solution, standing, and filtering to obtain a sodium alginate coated SOD-LF covalent conjugate; and dispersing the sodium alginate coated SOD-LF covalent conjugate and fucoidin in a chitosan solution, adding sodium tripolyphosphate, stirring for reaction, and centrifugally collecting to obtain the composition based on the synergistic effect of the SOD-LF covalent conjugate and nerve regulation. According to the composition disclosed by the invention, the blood brain barrier transmittance is enhanced through the SOD-LF covalent conjugate, and the fucoidin is combined to regulate the intestinal flora-enteric brain axis to synergistically inhibit neuroinflammation and oxidative stress, so that anxiety and insomnia are improved.

A method of treating heart disease in a subject includes percutaneously introducing a catheter into vasculature of the subject. The catheter may include a neuromodulation element. The neuromodulation element may be positioned on a flexion element. The flexion element may deflect away from or toward a central axis defined by the catheter in response to an operator pulling or releasing a pull-wire. The neuromodulation element of the catheter can be positioned in a subclavian artery of the subject. The catheter can be used to selectively target and electrically stimulate at least one of a dorsal subclavian ansae or a ventral subclavian ansae. The method can include confirming stimulation of the dorsal subclavian ansae and / or the ventral subclavian ansae by monitoring a cardiac parameter. After confirming stimulation of the dorsal subclavian ansae and / or the ventral subclavian ansae, ablation energy can be provided to the dorsal subclavian ansae and / or the ventral subclavian ansae.

The invention relates to the technical field of nerve regulation and control combined electroencephalogram, in particular to a transcranial electrical stimulation combined electroencephalogram data processing method and device and a storage medium. The method comprises the steps that patient medical image information is acquired, patient personality information is determined based on the patient medical image information, and the patient personality information is patient brain treatment reference parameters needing to be collected by a patient in transcranial electrical stimulation; acquiring an electroencephalogram signal of a patient, and determining electroencephalogram oscillation data based on the electroencephalogram signal of the patient; if the electroencephalogram oscillation data meets a preset value, determining a highly excited state of the patient based on the electroencephalogram oscillation data and the patient personality information; if the high-excitation state of the patient accords with a preset high-excitation state, determining a stimulation opportunity based on the high-excitation state of the patient; and generating a transcranial electrical stimulation instruction based on the stimulation opportunity. The transcranial electrical stimulation treatment effect can be improved.

Embodiments of present disclosure provide systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for administering deep brain stimulation (DBS), and for evaluating the efficacy and efficiency of DBS for the treatment of neurological conditions (e.g., Parkinson's disease).

The invention provides albizia flower compound essential oil with sleep aiding and depression relieving functions and a preparation method of the albizia flower compound essential oil, and relates to the technical field of aromatherapy and natural product application. The compound essential oil takes an albizia flower low-temperature two-stage extract as a core carrier and is compounded with various functional essential oil components such as bitter orange leaf essential oil, FCF bergamot essential oil and Egypt nymphaea tetragona original essence, and the compound essential oil is prepared through three core innovations of albizia flower carrier synergistic technology, multi-channel nerve regulation design and safety strengthening design. The technical problems that existing sleep-aiding essential oil is single in effect and high in potential nerve irritation and the bioavailability of albizia flower flavonoid glycoside is low are solved. Experimental verification shows that the compound essential oil can shorten the sleep latency period by 52% and reduce the anxiety score by 47%, can cooperatively regulate the GABA energy system, 5-hydroxytryptamine secretion and hypothalamus-pituitary-adrenal axis through an olfaction-nerve reflex path, realizes efficient anxiety resistance, deep sleep promotion and emotion balance, and is suitable for people with various anxiety insomnia and emotional disorder.

The present invention relates to an implantable neuroregulator device comprising a hermetically sealed housing, in which an antenna for communicating with an external device and / or for wirelessly receiving electrical energy is positioned within the housing, in which a main part of the housing is electromagnetically transparent to radiation in a frequency range below 20 MHz, in particular between 5 MHz and 15 MHz.

The invention provides a device for treating at least one of rhinitis, congestion, and / or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, coughing, sneezing, nasal or throat irritation and itching, and difficulty sleeping. The device includes a shaft, a retractable and expandable end effector, and handle, that, as a whole, provide a high level of precise control and feedback to an operator during a procedure. The shaft includes an electrode array provided along a length thereof configured to deliver energy to specific target sites within the nasal passage and nasal cavity in conjunction with neuromodulation provided by the end effector.

The application provides a closed-loop neuroregulation method and system based on transcranial light, which comprises the following steps: obtaining scale data, brain blood oxygen information and brain electrical information of a target user, inputting the information into a pre-trained target brain function rehabilitation prediction model, outputting a brain function rehabilitation prediction result of the target user by the target brain function rehabilitation prediction model based on the information, and adjusting a light regulation scheme of the target user based on the brain function rehabilitation prediction result. Since the scale data, brain blood oxygen information and brain electrical information contain brain function information of the target user from multiple aspects, the target brain function rehabilitation prediction model obtains sufficient comprehensive input information, and can output an accurate brain function rehabilitation prediction result, thereby improving the accuracy of the light regulation scheme obtained based on the brain function rehabilitation prediction result, and further improving the gain of transcranial light regulation.

A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and / or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and / or reverse the growth of a prostate gland or a prostate tumor.

The invention provides an essential oil composition for improving sleep quality, and relates to the field of plant essential oils, the essential oil composition comprises the following raw materials by mass: 15-20% of rose geranium essential oil, 15-20% of organic lavender essential oil, 30-40% of organic Provenus lavender essential oil, 15-20% of organic Atlantic cedar essential oil, and 10-15% of West Indian sandalwood essential oil. The essential oil composition is used for improving sleep, chemical components of different essential oils complement and cooperate, and a composite effect is achieved on multiple aspects of central nervous system sedation, emotion stabilization, endocrine balance, vegetative nerve regulation and the like.

Systems and methods for controlling autonomic symptoms or side effects via spinal cord stimulation are discussed. An exemplary neuromodulation system comprises an electrostimulator to provide spinal cord stimulation (SCS) to a neural target, a user interface device to receive a user input including an autonomic symptom and affected anatomy, and a controller circuit to determine or adjust a stimulation parameter based at least on the autonomic symptoms and the affected anatomy. Spinal cord stimulation can be delivered in accordance with the determined or adjusted stimulation parameter to alleviate the autonomic symptom, or to treat or alleviate autonomic disorders.

A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and / or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and / or reverse the growth of a prostate gland or a prostate tumor.

Systems and methods for coordination of medication adjustment for neuromodulation therapy are disclosed. An exemplary system comprises a processing system. The processing system may receive medication data associated with administration of medication from a. patient in an absence of administering electrostimulation to the patient. The processing system may receive stimulation data, associated with administration of electrostimulation therapy to the patient while the patient is not being administered medication. The processing system may compare the medication data to the stimulation data to provide a comparison. The processing system may generate a medication schedule and an electrostimulation schedule based on the comparison to increase efficacy of therapy and minimize side effects.

Provided are methods for treating depression and depression-related conditions by combining administration of pharmacologic agents and neuromodulation induced by transcranial electrical stimulation.

Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and / or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.