63 results about "Brain model" patented technology

The invention discloses a transcranial stimulation magnetic therapy coil navigation method, a transcranial stimulation magnetic therapy coil navigation system, a storage medium and equipment. The method comprises the following steps: acquiring three-dimensional structure information of the head of a target object, magnetic resonance imaging (MRI) data of an individual target object, or three-dimensional model data obtained by matching from a general MRI template library; real-time surface geometric information of the head of the target object is collected through an infrared optical tracking system; performing registration fusion on the three-dimensional structure information and the real-time surface geometric information, and generating an individualized three-dimensional brain model synchronized with a real space coordinate system on a navigation interface; the spatial position and posture of the optical marker fixed on the magnetic therapy coil are tracked in real time through an infrared optical tracking system and correspondingly mapped to the individualized three-dimensional brain model, and visual navigation of the magnetic therapy coil relative to the brain anatomical structure is achieved. Through the individualized three-dimensional navigation and real-time visualization technology, the problems that a traditional TMS is low in positioning precision, invisible in operation and poor in treatment repeatability are solved.

The invention discloses an optical and neural feedback multi-modal data analysis method for a nerve regulation target, and belongs to the technical field of cranial nerve treatment, and the method specifically comprises the steps: receiving a head movement instruction of a patient through an interactive interface, pausing transcranial magnetic stimulation after receiving the instruction, and switching to a head movement monitoring state; an infrared optical navigation device is combined with a magnetic resonance image to construct an individualized brain three-dimensional model, head position changes are tracked in real time, and autonomic nerve feedback signals are collected at the same time; synchronously aligning the head coordinates with the neural feedback signals to generate a multi-modal data set, and analyzing relevance to obtain real-time regulation and control parameters; the positioning and stimulation intensity of the transcranial magnetic stimulation coil are adaptively adjusted according to the parameters, and related information is displayed on a treatment interface; after the head of the patient finishes moving and is stable, a rapid re-calibration process is automatically triggered, high-precision monitoring is recovered, and magnetic stimulation output is reactivated; according to the invention, the treatment stability and adaptability are improved.

A method for performing artificial intelligence (AI) alignment on a generative AI model (GAIM), the method includes receiving a content item, which is generated by the GAIM. A computerized brain model, which has been trained to simulate responses of at least one human to content items generated by the GAIM, is applied to the content item. The AI alignment is performed on the GAIM based on a simulated response of the computerized brain model to the content item.

The invention provides a multi-frequency time-domain interference stimulation simulation optimization method and device. The method comprises the following steps: constructing a corresponding Gaussian function according to time-domain interference stimulation parameters for a target clinical user, and obtaining Fourier series of each channel of a transcranial electrical stimulator; generating a brain model based on the brain T1 weighted imaging data, and setting corresponding target spot position information to optimize the target spot electric field direction in any direction; determining an effective electrode arrangement area of each axial section of the craniocerebral model and arranging electrodes; and optimizing the electrodes arranged on each axial section so as to determine each grid of the craniocerebral model and the intensity amplitude of the time domain interference stimulation electric field, and optimizing the input current of each channel. According to the invention, multi-frequency stimulation simulation optimization for each channel of the transcranial electrical stimulator can be realized, the focusing performance of time domain interference stimulation can be improved, the calculation complexity of time domain interference stimulation parameter configuration can be reduced, and personalized time domain interference stimulation simulation can be effectively and quickly realized in combination with clinical data.

The present application relates to a kind of brain stimulation target point fast positioning method based on facial recognition and AI neural navigation, by obtaining the MRI data of user's head, construct the three-dimensional digital brain model including brain function partition information;Acquisition facial three-dimensional point cloud, with the head surface model reconstructed by MRI registration, establish the space mapping of actual head and brain model;Based on this mapping, determine stimulation target point on model.In treatment, real-time tracking head pose using optical system, and in navigation interface fusion display brain model, target point and the real-time position and angle of magnetic stimulation coil.Determine the best target stimulation angle of coil according to the gyri and sulci orientation of target point, guide operator to adjust coil pose by comparing the difference between real-time angle and target angle.The present application realizes the fast, accurate, visual positioning and dynamic maintenance of target point in transcranial magnetic stimulation treatment, and upgrades the traditional experience-dependent operation to individualized, real-time feedback precision navigation treatment.

Aspects provide systems and methods for utilizing quantum computing systems for processing of data generated by quantum sensor. For example, magnetic field data may be captured from a brain using a quantum sensor array. This magnetic field data may then be processed using a quantum computing apparatus including a plurality of qubits in order to generate a model of the brain.

The invention discloses a positioning and delimiting method and system for a cortex pathological focus based on an intracranial electroencephalogram signal. The method comprises the following steps: constructing an individualized three-dimensional navigation model; obtaining an original intracranial electroencephalogram signal; generating a plurality of representative segments according to the original intracranial electroencephalogram signals; analyzing the original intracranial electroencephalogram signal and the plurality of representative segments so as to obtain a network analysis core index; generating a fusion type three-dimensional brain model according to the network analysis core index and the individualized three-dimensional navigation model; generating a space-time three-dimensional electroencephalogram model and an electrophysiology functional area distribution diagram according to the fused three-dimensional brain model and the network analysis core indexes; and according to the space-time three-dimensional electroencephalogram model and the electrophysiology functional area distribution map, generating accurate electrophysiology positioning and delimiting information of the cortical pathological focus. According to the invention, accurate electrophysiological delimitation of intra-operative cortical pathological lesions (glioma, hemangioma, focal cortical dysplasia and the like) is realized.

The application relates to a control method for dynamic walking of a biped robot and the biped robot, and belongs to the technical field of robot control, which comprises the following steps: 1, a self-recurrent cerebellar model neural network is used to establish a dynamic model of the biped robot with a disturbance term, and dynamic robust walking of the biped robot is converted into a problem of realizing stability of a multi-input multi-output nonlinear system with a bounded uncertain term; 2, an adaptive self-recurrent cerebellar model neural network error observer is designed to estimate an error upper limit; 3, an adaptive law of network weight is designed to realize real-time updating of the network weight space and to adjust parameters of each learning factor; and 4, a boundary value estimation algorithm is used to compensate for an estimation error and feedback to a robot walking system, so that the biped robot can realize asymptotic stable walking. The application enables the control system to adapt to time-varying characteristics of the biped walking system on line, and has continuous learning and adaptive capacity for unknown dynamics.

The invention relates to a method for inferring epileptogenicity of a brain region not observed to be recovered or not observed to be not recovered in a seizure activity of a brain of an epilepsy patient, comprising the steps of: providing a computerized model modeling individual regions of a primate brain and connectivity between said regions; providing said computerized model with a model capable of reproducing the dynamics of a seizure in a primate brain; providing structural data of a brain of an epilepsy patient and using said structural data to individualize the computerized model in order to obtain a virtual epilepsy patient (VEP) brain model; translating a state space representation of the virtual epilepsy patient (VEP) brain model into a probabilistic programming language (PPL) using probabilistic state transitions in order to obtain a probabilistic virtual epilepsy patient brain model (BVEP); and acquiring electroencephalogram or magnetoencephalogram data of the brain of the patient and fitting the probabilistic virtual epilepsy patient brain model against said data in order to infer the epileptogenicity of said brain region not observed.

The application discloses an individualized transcranial electrical stimulation system and method based on a multi-scale fusion brain model, which comprises the following modules: a large-scale brain model construction module, which is used for reconstructing an individualized brain function connection matrix by using electroencephalogram (EEG) data, then constructing an individualized large-scale brain model based on an average field model, and equivalent transcranial electrical stimulation to an external current input of the large-scale brain model, and constructing a large-scale brain model under the action of external stimulation; a microscopic neural circuit dynamics model construction module, which is used for fusing single neuron dynamics and synaptic plasticity, adopting a coupled leaky integrate-and-fire model and a spike-timing-dependent plasticity model to establish long-term plasticity between synapses, and then establishing a local neural circuit model through a stimulation target and downstream brain areas; an individualized multi-scale fusion brain model construction module, which is used for replacing corresponding nodes in the large-scale brain model with the local neural circuit model, and constructing an individualized multi-scale fusion brain model; and a stimulation response simulation module, which is used for adjusting transcranial electrical stimulation parameters by using the constructed individualized multi-scale fusion brain model, and obtaining EEG activity and short-term response and long-term effect. The application can more accurately describe the complexity of brain activity by establishing an individualized multi-scale fusion brain model.

Techniques for automatically detecting a seizure of a patient are presented. The techniques include: obtaining patient EEG data, where the patient EEG data represents an EEG of the patient for a plurality of channels, each channel representing a respective location in or on a brain of the patient; evaluating a tendency to act as a sink for each channel; determining, for each tendency to act as a sink, a respective energy distribution according to frequency; assessing an entropy of each energy distribution according to frequency; measuring, from at least one of the plurality of entropy quantifications, at least one sink tendency entropy drop value; identifying, based on the sink tendency entropy drop value, a presence of a patient seizure proximate to a time of a sink tendency entropy drop; and outputting an indication of the patient seizure.

This invention relates to a method and apparatus for dynamic tracking and follow-up positioning of a robotic arm for brain stimulation. The method includes establishing a spatial mapping relationship between multiple coordinate systems, transforming the coordinates of the stimulation target point and the initial cortical normal vector determined in a three-dimensional digital brain model to the robotic arm's base coordinate system to obtain the first target position and axis, and controlling the robotic arm to align the stimulation coil. Real-time acquisition of head pose change data of the stimulated subject is used to calculate the real-time updated coordinates of the target point in the robotic arm's base coordinate system, thereby determining the second target position and axis that the stimulation coil needs to follow. Combining the geometric and electromagnetic characteristic parameters of the stimulation coil, the tracking target pose in the robotic arm's end-effector coordinate system is calculated. Joint control commands are generated based on the deviation between the target pose and the actual pose to drive the robotic arm movement, thereby stably maintaining the effective stimulation field of the stimulation coil continuously covering the predetermined intracranial target point during head pose changes, solving the problem of off-target movement caused by head motion.

The invention relates to a brain stimulation target quick positioning method based on facial recognition and AI (artificial intelligence) neural navigation, which comprises the following steps of: constructing a three-dimensional digital brain model containing brain function partition information by acquiring head MRI (magnetic resonance imaging) data of a user; acquiring face three-dimensional point cloud, registering the face three-dimensional point cloud with a head surface model reconstructed by MRI, and establishing space mapping between an actual head and a brain model; based on this mapping, a stimulation target is determined on the model. During treatment, the optical system is used for tracking the head posture in real time, and the real-time positions and angles of the brain model, the target spot and the magnetic stimulation coil are fused and displayed on a navigation interface. The optimal target stimulation angle of the coil is calculated according to the cortex sulcus return direction at the target point, and an operator is guided to adjust the position and posture of the coil by comparing the difference between the real-time angle and the target angle. According to the invention, the rapid, accurate and visual positioning and dynamic maintenance of the target spot in transcranial magnetic stimulation treatment are realized, and the traditional operation depending on experience is upgraded to individualized and real-time feedback accurate navigation treatment.

Disclosed in the present application are a method and apparatus for deriving effective connectivity information, a method and apparatus for training a digital twin brain model, and a device. The method comprises: determining perturbation data of a first brain node among at least two brain nodes and brain neural data of the at least two brain nodes in a time series; by means of a digital twin brain model, and, on the basis of the perturbation data of the first brain node and the brain neural data of the at least two brain nodes in the time series, obtaining first predicted neural data of the at least two brain nodes at the next moment; and, on the basis of the first predicted neural data of the at least two brain nodes at the next moment and second predicted neural data of the at least two brain nodes at the next moment, determining brain effective connectivity information from the first brain node to a second brain node. On the basis of a training data set, a time series prediction network is trained to obtain the digital twin brain model.

The application provides an ultrasonic craniocerebral tomography method based on a physically embedded neural network, and steps are as follows: firstly, according to the distribution characteristics of a craniocerebral biological tissue, a real physical CT brain model is converted into a craniocerebral acoustic velocity distribution map; secondly, according to the craniocerebral velocity distribution map and the physical characteristics of craniocerebral ultrasonic signal propagation, a sound field time domain signal is acquired; thirdly, the sound field time domain signal is subjected to data preprocessing to acquire a frequency domain data matrix, and a numerical simulation database is established; then, a neural network structure based on a full waveform inversion algorithm and embedding physics is built, and the network is trained by using the craniocerebral acoustic velocity distribution map and the frequency domain data matrix to obtain a combination of optimal network hyperparameters; finally, the frequency domain data matrix to be predicted is input into the network to realize high-precision and real-time ultrasonic craniocerebral tomography. The application realizes quantitative imaging and evaluation of brain structure, and has the advantages of fast imaging speed and high imaging precision.

This application discloses a method and apparatus for processing brain electric fields. The method includes: acquiring a three-dimensional model of the brain; the three-dimensional model includes M voxels and brain region labels for each voxel in the M voxels; sequentially inputting current to each pair of electrodes in N pairs of electrodes deployed in the three-dimensional model; determining a guiding field matrix based on the conductivity corresponding to the brain region label of each voxel in the three-dimensional model; the guiding field matrix is ​​used to characterize the electric field distribution at each voxel location under stimulation by each pair of electrodes; and determining the envelope of the electric field distribution of the three-dimensional model based on the guiding field matrix. This method can determine the envelope of the electric field distribution of the three-dimensional brain model with high accuracy.

The application discloses a scalp EEG signal-based brain internal nerve activity tracing method and system, and the method comprises the following steps: a virtual brain model is built by using a neurocluster model with biological interpretation, a whole brain map and brain physiological connection, and the number of the neurocluster model is recorded; brain internal nerve activity generated by the virtual brain model is converted into scalp EEG signals according to an EEG measurement model; a brain internal nerve activity tracing neural network is constructed; internal brain activity data with spatial characteristics and time characteristics are generated by using the virtual brain model, and corresponding EEG signals are obtained through the EEG measurement model; the obtained internal brain activity data and the corresponding EEG signals are used to construct a data set for training the brain internal nerve activity tracing neural network. The brain internal nerve activity tracing neural network is constructed by cascading a spatial module and a time module, so that the stability and accuracy of brain internal nerve activity tracing are improved.

The VEM-robot emotional right-brain model construction method decomposes the robot's brain into an emotional right brain, an intellectual left brain, and a motor cerebellum, forming the embodied or humanoid robot operating system VEM-ROS. This enables emotional communication between the robot and humans or other robots. Human output is used as the perceptual spectrum, and robot output as the deductive spectrum. Both the perceptual and deductive spectra are segmented, synthesized, and aligned using the emotional rhythm of the multimodal VEM-Token. LLM-Token decomposition of the large language model calculates lexicalized logical perception, and VEM-Token decomposition calculates the micro-expressions of multimodal emotional components. VEM-ROS also includes priority and interruption mechanisms, VEM memory mechanisms, dialogue relationships, craniofacial and limb sensors and actuators and interfaces, robot cloning, and operating system encapsulation. The right-brain model supports emotional micro-expression communication between the robot and humans, similar to the Turing test, and is expected to distinguish whether the emotional test subject is a robot or a human.

The embodiment of the invention provides a simulation method and device for craniocerebral growth and a storage medium, and belongs to the technical field of images. The method comprises the following steps: constructing three-dimensional brain models in one-to-one correspondence with standard brain CT sample images corresponding to different growth time periods; taking the three-dimensional brain model corresponding to an initial time period in different growth time periods as an initial simulation model for segmentation to obtain a plurality of brain model components; performing finite element solution of growth parameters on a gridding three-dimensional craniocerebral model obtained by gridding each craniocerebral model component to obtain a predicted craniocerebral model of the next growth time period; obtaining a first target growth parameter corresponding to the current growth time period according to the predicted craniocerebral model and the three-dimensional craniocerebral model in the same growth time period; and taking the predicted craniocerebral model as an initial simulation model to obtain a first target growth parameter of the next growth time period. According to the embodiment of the invention, the simulation efficiency and simulation precision of skull simulation can be considered.

This invention discloses a rapid incremental learning technique based on a spiking neuromorphic model, belonging to the field of computer vision technology. The invention selects the YOLOv3-tiny model as the base model for the SpikingYoLOv3 spiking neural network, and improves its adaptability. It uses the IF neuron model as the neuron model for SpikingYoLOv3. An incremental learning training method based on network expansion is employed for YOLOv3-tiny. The weights of the trained model are assigned to the newly constructed SpikingYoLOv3 model using an ANN-to-SNN conversion method. Poisson coding is used to encode the test images, converting them into asynchronous pulse sequences, which are then fed into the SpikingYoLOv3 model for testing. Comparative analysis with the corresponding YOLOv3-tiny model reveals that the SpikingYoLOv3 model has superior detection performance. Applying SpikingYoLOv3 to a battlefield environment enables accurate detection of different types of targets. This invention solves the problem of traditional network models needing retraining when encountering new tasks, providing a new solution for complex target detection tasks.

This invention discloses a brain simulation network resource allocation method based on network structure and transfer algorithm, belonging to the field of brain simulation technology. The method includes: extracting brain network information and abstracting cluster resource information; when cluster resources are sufficient, calculating the connectivity of neuron clusters in the brain model network structure based on the brain network information, and pre-allocating neuron clusters based on the connectivity of neuron clusters; using the pre-allocation result as the initial value for the transfer algorithm, iteratively optimizing the allocation of neuron clusters to obtain the iterative optimization result; merging all neuron clusters allocated to the same computing node into one neuron cluster based on the iterative optimization result to obtain the final resource allocation result; and actually creating the brain simulation network based on the resource allocation result to complete the brain simulation network resource allocation. This invention's resource allocation method reduces the storage space consumption of the brain model and improves the speed of brain simulation.

This application discloses a magnetic resonance-compatible time-interference neuromodulation system, comprising: an image acquisition module for acquiring structural magnetic resonance (SMR) images and functional magnetic resonance (fMRI) images; a localization simulation module for analyzing SMR images to determine the target brain region and construct a brain model, calculating an initial stimulation parameter set based on the brain model and initial stimulation commands, and updating the stimulation parameter set based on stimulation commands; an analysis module for analyzing fMRI images to obtain functional state determination results and spatial consistency determination results; an electrical stimulation module for receiving the initial stimulation parameter set and initial stimulation commands to output a time-interference electrical stimulation signal, and receiving stimulation commands to adjust the time-interference electrical stimulation signal; and a control module for generating the initial stimulation commands and generating stimulation commands based on the functional state determination results and spatial consistency determination results. The system provides highly real-time, multi-index closed-loop modulation of time-interference electrical stimulation, highly adaptable to clinical intervention and laboratory research tasks related to brain region modulation.

The application relates to the technical field of brain network construction, and particularly discloses a brain structure and metabolic image synchronously acquired brain network construction method and device, which comprises the following steps: acquiring a structure image and a metabolic image to be processed; registering the structure image to be processed to a standard brain template; registering the metabolic image to the standard brain template by taking the structure image as an intermediate; fusing brain structure information and metabolic information of the nuclear medicine image to obtain a metabolic image; performing brain partition processing on the metabolic image to form a multi-partition brain model; obtaining a co-correlation matrix by analyzing the correlation between multiple brain regions; and obtaining a metabolic brain network by optimizing the co-correlation matrix of the brain model. The brain structure and metabolic image synchronously acquired brain network construction method and device can more effectively find metabolic differences between brain disease patients and normal people in network attribute indexes, and provide valuable information for brain development, maturity and aging.

A biomechanically realistic brain model for impact testing comprises white matter simulant materials and gray matter simulant materials positioned to correspond with anatomical brain structure. The white matter simulant comprises anisotropic hydrogels with embedded magnetically-responsive, electrically-responsive, thermally-responsive, and / or mechanically-responsive particles that exhibit directionally-dependent stress-strain responses. The gray matter simulant comprises isotropic hydrogels or silicones, particularly siloxanes, that exhibit uniform stress-strain responses to applied forces. The materials are cast, injected, printed, or formed in anatomically correct positions and share realistic interfaces. The brain model accurately imitates physical brain responses during impact tests, particularly angular impacts, providing realistic testing results for biomechanical analysis.

The invention provides a reconfigurable brain-like computing system and method based on a coarseness modular operator, and relates to the technical field of data processing.A software general operator library abstracts a brain-like model defined by a user into a calling sequence of a software general operator and a configuration requirement of a hardware operator corresponding to the calling sequence in a unified mode; the intelligent configuration middleware further constructs a task dependency graph according to the calling sequence and divides the task dependency graph, performs template matching and node synthesis on a division result according to a configuration requirement, and outputs a system configuration result which can be directly used for hardware deployment; and the hardware basic operator library automatically deploys a plurality of hardware operators following a unified operator protocol to form executable hardware implementation. According to the method, rapid and automatic conversion from flexible algorithm description to efficient special hardware is realized, the development efficiency, the resource utilization rate and the expandability of a brain-like computing system are remarkably improved, and a super-large-scale brain-like computing task of a hundred million-level neuron and a thousand billion-level synapse can be effectively supported.

To provide a driving support device capable of considering a driver's brain model (driver internal model) to perform appropriate driving support optimized for each driver.SOLUTION: A driving support device includes: traveling scene recognition means 31; driving target calculation means 32 for calculating a target driving operation and target vehicle behavior; driving operation detection means 33 for detecting a driver's driving operation; driving detection means 34 for detecting behaviors of a vehicle; driver determination means 36 for determining the level of the driver's skill in a traveling scene subject to determination; and support mode setting means for setting the mode of notification by HMI 26 depending on the determination of the level of the driver's skill by the driver determination means 36.SELECTED DRAWING: Figure 2

The application provides a distributed computing and communication system with brain-like consciousness and an implementation method thereof, comprising: a plurality of computing nodes and a consciousness state management module; each computing node comprises a computing unit, a storage unit and a communication unit; the communication units constitute a network on chip (NoC) as a whole; the computing unit and the storage unit are connected with nodes of the NoC, and the cooperation and data sharing between the computing nodes are completed through an efficient communication protocol; and the consciousness state management module is configured on each computing node to constitute a consciousness management system of a CTM, that is, a brain-like model of the CTM, so that the mutual cooperation between each node dynamically adjusts the computing strategy to complete a complex computing task. Each computing node of the application is configured with a consciousness state management module, can perceive the real-time state of the node, and accepts the input from other nodes; through analyzing the data, the module can adjust the computing strategy of the node in real time, and realize the formation and dynamic adjustment of the consciousness.

The application provides a brain magnetic source positioning method based on a nearest neighbor multivariate linear regression model. The method comprises the following steps: constructing a brain model based on the nearest neighbor multivariate linear regression model and representing the space-time correlation between brain source activities; constructing a source covariance matrix in the model based on a graph Laplacian smoother, and representing the space correlation of the covariance hierarchy between the source activities; and making reasonable assumptions for the model based on Bayesian inference and convex optimization theory, and deriving a formula for iterative solution of the model parameters. The source positioning algorithm realized by the application can obtain more accurate source estimation, including accurate positioning of the source position, the range size and the source time waveform estimation, and provides a solid technical foundation for medical applications of the brain magnet.

A biomechanically realistic brain model for impact testing comprises white matter simulant materials and gray matter simulant materials positioned to correspond with anatomical brain structure. The white matter simulant comprises anisotropic hydrogels with embedded magnetically-responsive, electrically-responsive, thermally-responsive, and / or mechanically-responsive particles that exhibit directionally-dependent stress-strain responses. The gray matter simulant comprises isotropic hydrogels or silicones, particularly siloxanes, that exhibit uniform stress-strain responses to applied forces. The materials are cast, injected, printed, or formed in anatomically correct positions and share realistic interfaces. The brain model accurately imitates physical brain responses during impact tests, particularly angular impacts, providing realistic testing results for biomechanical analysis.

The invention discloses an in-vitro implantation simulation platform, and the platform comprises a brain model which is provided with an inner cavity, and the wall surface of the brain model is provided with an implantation port, a communication inlet, and a communication outlet which are communicated with the inner cavity; the shaping piece is detachably arranged in the inner cavity; according to the in-vitro implantation simulation platform, when the inner cavity is filled with the brain parenchyma simulant, the shaping piece is installed between the communicating inlet and the communicating outlet, after filling is completed, the shaping piece is detachable so that a hollow channel can be formed in the brain parenchyma simulant, and the hollow channel communicates with the communicating inlet and the communicating outlet and is used for allowing the cerebrospinal fluid simulant to flow through. According to the in-vitro implantation simulation platform provided by the embodiment of the invention, the mechanical properties of the brain tissue and the flow of the cerebrospinal fluid are integrated into the in-vitro model, the influence of the flow of the brain tissue and the flow of the cerebrospinal fluid on the implant can be simulated at the same time, the repeatability is high, and a standardized simulation platform is provided for mechanical property evaluation and optimization design of the brain implant. And the requirements of animal experiments can be reduced.