14 results about "Brain lesions" patented technology

A system and method automatically detect, in MR images, WM lesions exhibiting a central vein sign. A set of MR images of a brain lesion is acquired, using images of the set as input to different ML algorithms. A first ML algorithm classifies inputted image(s) into first or second classes. The first class includes CVS+ / − and the second class CVSe lesions. A second ML algorithm classifies inputted image(s) into third or fourth classes. The third class includes CVS+ lesions and the fourth central vein sign− lesions. For each set, probability values are used that the set belongs to classes as inputs to a final classifier performing a final classification of the set into second, third, or fourth classes. For each class, the final classifier outputs final probability that the set belongs to the class. The second, third or fourth class with highest probability value is provided through an interface.

This invention relates to the field of biomedicine, disclosing a drug carrier, its construction method, and its applications. The nanoprobe of this invention uses fluorescent nanomaterials as a matrix, with polysaccharide ligands and photosensitizers coupled to it. The polysaccharide ligands cross sugar-specific transport channels on the bacterial cell membrane to enter the bacterial interior, simultaneously carrying the photosensitizer into the bacteria. The inactivated bacteria lose their microbial activity but retain their ability to cross the blood-brain barrier, reaching brain lesions to deliver drugs. Furthermore, the photosensitizer can be used for photothermal therapy of central nervous system diseases such as brain tumors and inflammatory infections under light conditions.

The application discloses a brain deep lesion space position positioning device and method in the technical field of neurosurgical instruments, and relates to the technical field of medical devices. The device comprises an ultrasonic probe, a sliding rail fixedly connected with the ultrasonic probe, and a coaxial biopsy needle in sliding connection with the sliding rail. The coaxial biopsy needle comprises a fixed sleeve fixedly connected with the sliding rail, a needle sheath penetrating through the fixed sleeve, a needle sheath limiter connected with the needle sheath, a needle core penetrating through the needle sheath, and a needle core limiter fixedly connected with the needle core. The needle core limiter is in sliding connection with the sliding rail. The application can solve the technical problem that, when facing brain deep lesions, the existing technology has the problems of brain drift in traditional navigation and insufficient path visibility caused by simple ultrasonic guidance, and cannot accurately guide the puncture path.

Some methods comprise, for each of one or more lesions of a patients brain, from data taken at first and second times, determining two or more lesion characteristics including a lesion's volume change and whether the lesion moved toward a center of the brain. Some methods comprise, for each lesion, determining whether one or more criteria are satisfied, including a volume-and-displacement-based criterion that is satisfied when the change in the volume of the lesion is less than zero and the lesion moved toward the brain's center or the change in the volume of the lesion is greater than zero and the lesion did not move toward the brain's center. Some methods comprise characterizing whether the patient has multiple sclerosis and / or the progression, regression, or stability of multiple sclerosis based at least in part on the assessment of the one or more criteria for each of the lesion(s).

The invention discloses a head limiting device for craniocerebral focus detection, and relates to the technical field of medical treatment. The device comprises a protection plate, and the top of the protection plate is fixedly connected with a neck support; a fixing device is arranged at the top of the protection plate and comprises a fixing plate, and the side face of the fixing plate is fixedly connected with the side face of the protection plate. According to the invention, a rotating handle is rotated to drive a reciprocating screw rod to rotate force to be matched with a fixed rod, a movable rod, a rotating rod and other components in the fixing device, so that the effect of driving a limiting block to displace through the displacement of a mounting plate is realized, and the effect of fixing and limiting the head of a patient is achieved; it is ensured that the head of a patient keeps stable and fixed in the detection process, it is crucial to ensure that a doctor can obtain clear and accurate focus position information, more accurate diagnosis and treatment planning are facilitated, and the patient can feel more relaxed and comfortable in the detection process.

The application provides an electrode assembly and system for accurate positioning of a deep brain lesion target. The electrode assembly comprises a first catheter and an electrode probe. The first catheter comprises a penetration end, an exit end and a catheter body, and the exit end is provided with at least one blocking part. The electrode probe comprises a proximal end and a distal end, and the distal end is arranged in the first catheter and is arranged offset relative to the central axis of the first catheter; wherein the electrode probe can rotate around the central axis in the first catheter to adjust the offset position of the distal end in the first catheter, so that the distal end can avoid the blocking part or be blocked by the blocking part to bend relative to the central axis of the first catheter during the process of penetrating out of the first catheter. By adjusting the rotation of the electrode probe in the first catheter, the distal end can select different penetration paths, and a large range of electrophysiological signal collection is realized, which is helpful for accurately positioning the position relationship between the stimulating electrode and the target nucleus.

The present application relates to a kind of agglutinin joint targeting peptide modified nanosphere and its preparation method and application, belong to the biomedicine technical field.To solve the problem that the existing drug delivery system is difficult to have the integration of nasal brain barrier breakthrough, nasal long-term retention, brain lesion targeting, broad-spectrum drug loading and high biological stability, the present application provides a kind of agglutinin joint targeting peptide modified nanosphere, including polymer matrix core, biomimetic cell membrane shell and double-ligand functionalization surface crown layer in turn from inside to outside.The nanosphere of the present application can prolong the nasal retention time and efficiently penetrate the nasal mucosa barrier by relying on the synergistic effect of core-shell-crown three-layer structure, realize transnasal brain and lesion precise targeting, improve drug delivery efficiency and efficacy, and reduce toxic side effects.The nanosphere of the present application has a wide range of drug loading spectrum, suitable for the drug demand of various central nervous system diseases, and has excellent clinical transformation value and application prospect.

The invention relates to a bionic nano delivery platform for brain targeting and photothermal therapy, a preparation method of the bionic nano delivery platform and application of the bionic nano delivery platform in treatment of neurodegenerative diseases. The platform is composed of a drug-loading core and a functionalized shell, wherein the drug-loading core is a cycloastragenol-loaded liposome; the functionalized shell covers the drug loading core and is composed of a microcolloid cell membrane and a near-infrared two-region photo-thermal material dispersed in the microcolloid cell membrane. According to the structure, through cell membrane bionic modification, a platform is endowed with good brain focus targeting, efficient immune escape ability and a remarkable drug enrichment effect, and collaborative delivery and controlled release of cycloastragenol and a photo-thermal material can be achieved. The platform and the system have the comprehensive advantages of being accurate in brain targeting, remarkable in treatment synergistic effect and good in biocompatibility, and have wide clinical application prospects in the field of targeted therapy of neurodegenerative diseases.

The present disclosure relates to methods of administering [18F]-FACBC. The present disclosure also relates to use of [18F]-FACBC in methods for imaging, diagnosing, and monitoring of brain lesions.

A method of imaging a biological material having a component that exhibits an ultra-short transverse relaxation time after excitement by electromagnetic energy is disclosed. More specifically, balanced steady state free precession ultra-short echo time (bSSFP UTE) magnetic resonance imaging (MRI) is used in combination with 3D center-out trajectory data collection and image subtraction techniques, to yield accurate high spatial resolution images of a material component having an ultra-short transverse relaxation time. In an embodiment, the 3D center-out trajectory can be a 3D rosette k-space trajectory. The disclosed methods can be used to image, among other things, biological materials such as without limitation, cortical and trabecular bones, lung parenchyma, tendons, and ligaments. In a particular example, the disclosed methods are used to image the myelin bilayer in brain white matter, such as for example, to detect, treat, or monitor brain lesions in multiple sclerosis patients.

The embodiment of the specification provides a puncture path determination system, method, device and medium for a brain lesion, the system comprising a measurement handle, a positioning device and a computing device; the positioning device is used to acquire the spatial position and pose of the probe end point of the measurement handle, select a reference surface in a medical image scanning picture, select three feature points on the body surface as registration points on the layer, acquire the spatial coordinates of the registration points by the probe end point of the measurement handle contacting the registration points, so as to determine the reference surface; acquire the position information of the target point relative to the reference surface through the medical image scanning data, and obtain the spatial position coordinates of the target point; and according to the spatial position coordinates of the target point, the direction of the measurement handle is adjusted to point to the target point, so as to determine the direction and depth of the puncture path. The above technical scheme is convenient for positioning information acquisition, simple to operate, avoids the trauma caused by the device to the patient, is easy to popularize, and guarantees the operation effect of the patient.

The invention discloses a deep brain lesion spatial position positioning device and method in the technical field of neurosurgical operating instruments. The device comprises an ultrasonic probe, a sliding rail fixedly connected with the ultrasonic probe and a coaxial biopsy needle slidably connected with the sliding rail. The coaxial biopsy needle comprises a fixing sleeve fixedly connected with the sliding rail, a needle sheath penetrating through the fixing sleeve, a needle sheath limiter connected with the needle sheath, a needle core penetrating through the needle sheath and a needle core limiter fixedly connected with the needle core. And the needle core limiter is connected with the slide rail in a sliding manner. According to the method, the technical problems that in the prior art, when deep brain lesion occurs, path visibility is insufficient due to brain drifting of traditional navigation and pure ultrasonic guidance, and a puncture path cannot be accurately guided can be solved.

A system for predicting a survival outcome of a brain tumor patient includes a computing device with at least one processor and a non-volatile computer-readable media. The non-volatile computer-readable media contains instructions executable on the processor to: transform a resting-state fMRI dataset obtained from the patient into a functional connectivity matrix comprising a plurality of matrix elements, each matrix element comprising a correlation of resting-state fMRI activities of a first and second region of interest from a plurality of pre-selected regions of interest within the patient's brain, transform the functional connectivity matrix into the predicted survival outcome using a machine learning model, and output the predicted survival outcome.