4 results about "Brain lesions" patented technology

The application discloses a brain deep lesion space position positioning device and method in the technical field of neurosurgical instruments, and relates to the technical field of medical devices. The device comprises an ultrasonic probe, a sliding rail fixedly connected with the ultrasonic probe, and a coaxial biopsy needle in sliding connection with the sliding rail. The coaxial biopsy needle comprises a fixed sleeve fixedly connected with the sliding rail, a needle sheath penetrating through the fixed sleeve, a needle sheath limiter connected with the needle sheath, a needle core penetrating through the needle sheath, and a needle core limiter fixedly connected with the needle core. The needle core limiter is in sliding connection with the sliding rail. The application can solve the technical problem that, when facing brain deep lesions, the existing technology has the problems of brain drift in traditional navigation and insufficient path visibility caused by simple ultrasonic guidance, and cannot accurately guide the puncture path.

The application provides an electrode assembly and system for accurate positioning of a deep brain lesion target. The electrode assembly comprises a first catheter and an electrode probe. The first catheter comprises a penetration end, an exit end and a catheter body, and the exit end is provided with at least one blocking part. The electrode probe comprises a proximal end and a distal end, and the distal end is arranged in the first catheter and is arranged offset relative to the central axis of the first catheter; wherein the electrode probe can rotate around the central axis in the first catheter to adjust the offset position of the distal end in the first catheter, so that the distal end can avoid the blocking part or be blocked by the blocking part to bend relative to the central axis of the first catheter during the process of penetrating out of the first catheter. By adjusting the rotation of the electrode probe in the first catheter, the distal end can select different penetration paths, and a large range of electrophysiological signal collection is realized, which is helpful for accurately positioning the position relationship between the stimulating electrode and the target nucleus.

The present application relates to a kind of agglutinin joint targeting peptide modified nanosphere and its preparation method and application, belong to the biomedicine technical field.To solve the problem that the existing drug delivery system is difficult to have the integration of nasal brain barrier breakthrough, nasal long-term retention, brain lesion targeting, broad-spectrum drug loading and high biological stability, the present application provides a kind of agglutinin joint targeting peptide modified nanosphere, including polymer matrix core, biomimetic cell membrane shell and double-ligand functionalization surface crown layer in turn from inside to outside.The nanosphere of the present application can prolong the nasal retention time and efficiently penetrate the nasal mucosa barrier by relying on the synergistic effect of core-shell-crown three-layer structure, realize transnasal brain and lesion precise targeting, improve drug delivery efficiency and efficacy, and reduce toxic side effects.The nanosphere of the present application has a wide range of drug loading spectrum, suitable for the drug demand of various central nervous system diseases, and has excellent clinical transformation value and application prospect.

The embodiment of the specification provides a puncture path determination system, method, device and medium for a brain lesion, the system comprising a measurement handle, a positioning device and a computing device; the positioning device is used to acquire the spatial position and pose of the probe end point of the measurement handle, select a reference surface in a medical image scanning picture, select three feature points on the body surface as registration points on the layer, acquire the spatial coordinates of the registration points by the probe end point of the measurement handle contacting the registration points, so as to determine the reference surface; acquire the position information of the target point relative to the reference surface through the medical image scanning data, and obtain the spatial position coordinates of the target point; and according to the spatial position coordinates of the target point, the direction of the measurement handle is adjusted to point to the target point, so as to determine the direction and depth of the puncture path. The above technical scheme is convenient for positioning information acquisition, simple to operate, avoids the trauma caused by the device to the patient, is easy to popularize, and guarantees the operation effect of the patient.