18 results about "Cerebral trauma" patented technology

The present invention belongs to the technical field of medicine. Disclosed are a class of magnolol / honokiol derivatives, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are magnolol / honokiol nitrone derivatives as represented by general formulas (I) and (II). Such derivatives are prepared by means of artificial synthesis. Further provided are a pharmaceutical composition containing same, and the use thereof against inflammation, against cerebral infarction, in the treatment of amyotrophic lateral sclerosis, and against cerebral trauma.

The invention discloses a g-C3N4 nanosheet modified by a gold-palladium-nitrogen doped carbon ribbon as well as a preparation method and application of the g-C3N4 nanosheet. The preparation method comprises the following steps: doping UFR-NC into g-C3N4 to form a g-C3N4 / UFR-NC composite nanomaterial; the g-C3N4 / UFR-NC composite nanomaterial is used as a carrier, and gold-palladium core-shell particles are loaded on the g-C3N4 / UFR-NC composite nanomaterial, so that the g-C3N4 nanosheet modified by the gold-palladium-nitrogen doped carbon ribbon is obtained. The g-C3N4 nanosheet modified by the gold-doped palladium-nitrogen-doped carbon ribbons, disclosed by the invention, has multiple enzyme-like activities and good photocatalytic hydrogen production and hydrogen storage and release performance; meanwhile, under the enhancement effect of 808 nm near-infrared light illumination, the multi-enzyme activity is achieved, and the hydrogen storage and release performance is high. The traditional Chinese medicine composition can reduce oxidative stress injury in vivo and inhibit neuroinflammation, and has an obvious treatment effect on microglia mediated neuroinflammatory encephalopathy such as Parkinson's disease, Alzheimer's disease, cerebral trauma and cerebral apoplexy.

The invention provides a cerebral trauma semi-dark band image segmentation method and device, equipment, a medium and a product, and the method comprises the steps: obtaining at least two modal magnetic resonance images, inputting the at least two modal magnetic resonance images into a trained feature fusion module for fusion, and obtaining a fusion image; and inputting the fused image into a trained segmentation module for image segmentation to obtain a cerebral trauma semi-dark band region. According to the invention, the automatic identification of the cerebral trauma penumbra region is realized, and the identification efficiency of the cerebral trauma penumbra region is improved.

The invention provides an anesthesia device for emergency treatment of craniocerebral trauma. Relates to the technical field of medical anesthesia equipment. The emergency treatment anesthesia device for the craniocerebral trauma comprises a supporting frame, a medicament tank is fixedly installed on the supporting frame, a quantitative tank is fixedly installed at the bottom of the medicament tank, the medicament tank and the quantitative tank are communicated through a communicating pipe, an injection pump and an atomizer are arranged below the quantitative tank, and the atomizer is connected with the medicament tank through a connecting pipe. A liquid guide pipe is fixedly installed at the bottom of the quantitative tank, a two-branch pipe is fixedly installed at the bottom end of the liquid guide pipe, one end of the two-branch pipe is fixedly connected with a liquid inlet port of the injection pump, and the other end of the two-branch pipe is fixedly connected with a liquid inlet port of the atomizer. Intravenous injection and inhalation type anesthesia can be integrated, a single anesthesia mode or a combined anesthesia mode can be flexibly selected according to the real-time illness state of a patient, and anesthetic medicine mixing and diluting can be rapidly completed according to physical sign parameters of special crowds.

The invention discloses 2-sulfur-3-(piperidinedithio) phthalide (I), pharmaceutically acceptable salts thereof, a preparation method of the 2-sulfur-3-(piperidinedithio) phthalide (I), a pharmaceutical composition of the 2-sulfur-3-(piperidinedithio) phthalide (I) and application of the 2-sulfur-3-(piperidinedithio) phthalide (I) in preparation of drugs for treating and comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The invention discloses a multi-modal fusion portable cerebral trauma first-aid navigation system and method, and relates to the technical field of cerebral trauma first-aid navigation. The system comprises a handheld navigation device, a data acquisition module, a pose resolving module, a feature extraction module and a boundary recognition module. The handheld navigation equipment integrates a miniature ultrasonic probe and a 9-axis inertial measurement unit, a data acquisition module synchronously acquires intracranial ultrasonic echo sequence data and spatial motion parameters, and a pose resolving module resolves the spatial motion parameters in real time to determine real-time spatial pose data of the equipment in a head coordinate system. The feature extraction module inputs the ultrasonic echo sequence data into a pre-trained convolutional neural network model to output a multi-scale ultrasonic feature vector, and the boundary recognition module generates hematoma boundary dynamic labeling information in combination with the multi-scale ultrasonic feature vector and the real-time spatial pose data. The system is suitable for scenes of on-site first aid, patient transfer and the like, and assists medical staff in mastering the intracranial hematoma condition.

This invention provides a method and system for establishing a prognostic model for traumatic brain injury (TBI) based on multimodal data fusion and AI, belonging to the field of medical artificial intelligence technology. The method includes collecting patient clinical text and CT image data, performing preprocessing, extracting clinical text features and image data features, and constructing three major models: a TBI prognostic prediction model, a clinical model of the predictive efficacy of edema expansion on TBI prognosis, and a TBI cerebral edema expansion prediction model. The final output of the prognostic model prediction results includes patient risk stratification results, neurological function prognostic prediction results, and cerebral edema expansion prediction results. The system includes a data acquisition module, a data preprocessing module, a feature extraction module, a multimodal model construction module, and a result output module. This invention can accurately achieve risk stratification and prognostic prediction for TBI, effectively improving the accuracy and efficiency of diagnosis and treatment, reducing the risk of misdiagnosis and missed diagnosis, and providing strong support for improving patient prognosis.

The invention discloses a 3-(piperidine alkyl dithioalkyl) phthalide compound (I), pharmaceutically acceptable salts thereof, a preparation method thereof, a pharmaceutical composition thereof and application of the 3-(piperidine alkyl dithioalkyl) phthalide compound in preparation of drugs for treating and / or preventing nervous system related diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The application discloses a kind of postoperative infection risk early warning system of craniocerebral trauma patient.The system uses "multimodal perception-privacy computing-interpretable early warning-closed loop intervention" four-layer integrated architecture, including multimodal perception and fusion module, privacy computing hub module, interpretable early warning engine and intelligent closed loop intervention module connected in turn.Communication connection is integrated millimeter wave radar, flexible sensor array and MS@SLET sensor chip in multimodal perception and fusion module, realize multidimensional data high-fidelity acquisition;Privacy computing hub module is based on improved FlexFair federated learning framework, and data privacy protection and group prediction fairness are considered;Interpretable early warning engine realizes accurate early warning and generates structured attribution report by the CNN-Transformer hybrid model of stage perception attention mechanism;Intelligent closed loop intervention module realizes hierarchical early warning, individualized scheme matching and model incremental optimization.The application solves the bottleneck of the prior art, such as insufficient timeliness of early warning, imbalance between data utilization and privacy fairness, uninterpretable decision and early warning intervention fragmentation, shortens the infection index detection time to within 30 seconds, the system response time is less than 200 ms, the infection-related mortality rate is reduced by 65.4%, fully meets the requirements of laws and regulations such as "Personal Information Protection Law", and has very high clinical application value.

The invention discloses a 3-(piperidine alkyl sulfide or seleno) phthalide compound (I), pharmaceutically acceptable salts thereof, a preparation method thereof, a pharmaceutical composition and application thereof in preparation of drugs for treating and / or preventing nervous system related diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The utility model relates to the technical field of medical equipment, in particular to a brain trauma postoperative rehabilitation protection device which comprises a headrest supporting pad, the upper end of the headrest supporting pad is fixedly connected with a first air bag, the other end of the first air bag is communicated with an air bag pad, and the outer wall of the air bag pad is communicated with a plurality of second air bags which are evenly distributed. The outer wall of the first air bag communicates with an annular limiting bag, the other end of the annular limiting bag is fixedly connected with a first bandage, the right end of the first air bag is fixedly connected with a supporting ring, and the other end of the first bandage penetrates through the supporting ring and is detachably connected with the outer wall of the first bandage through a hook-and-loop fastener. When the dressing is fixed, the dressing enters the first air bag, the air bag cushion, the second air bags and the annular limiting bag, so that the first air bag, the air bag cushion, the second air bags and the annular limiting bag can be tightly attached to the head of the patient, and the purpose of improving the dressing fixing stability in an air bag inflation mode is achieved.

The application belongs to the technical field of biological medicine, and provides application of tyrosol sodium sulfate and derivative tyrosol compounds in preparation of brain health products. The structure of the tyrosol sodium sulfate and the derivative tyrosol compounds is shown as formula I, which can effectively reduce the infarction area after cerebral ischemia, and reduce cerebral edema caused by cerebral ischemia, and has wide application in resisting cerebral ischemia and improving cerebral edema and cerebral infarction caused by cerebral ischemia. Meanwhile, the tyrosol sodium sulfate and the derivative tyrosol compounds can effectively improve learning and memory ability, promote recovery of brain function, and have wide application in treating behavior / cognitive dysfunction diseases such as brain trauma, cerebrovascular accident, Alzheimer's disease and Parkinson's disease. Formula I.

The invention discloses 3-(piperidine alkyl sulfenyl) benzyloxy phthalide (I), pharmaceutically acceptable salts thereof, a preparation method thereof, a pharmaceutical composition thereof and application of the 3-(piperidine alkyl sulfenyl) benzyloxy phthalide (I) in preparation of drugs for treating and / or preventing nervous system related diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The invention discloses an amine alkoxy nicotine compound (I), pharmaceutically acceptable salts thereof, a preparation method thereof, a pharmaceutical composition thereof and application of the amine alkoxy nicotine compound in preparation of drugs for treating and / or preventing nervous system diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The invention relates to the technical field of postoperative nursing, and discloses a craniocerebral trauma postoperative nursing device which comprises a base with an empty groove formed in the top, a swing plate rotationally connected to the inner side of the empty groove, two placement grooves formed in the top of the swing plate and symmetrically distributed, and a swing unit arranged on the base. The swing unit comprises a swing component arranged on the base and a brake component arranged at the top of the swing component, and the swing component comprises a swing assembly arranged on the base. According to the craniocerebral trauma postoperative nursing device, through the swinging unit, a swinging plate swings left and right on the inner side of an empty groove, a patient is driven to swing left and right, balance rehabilitation training is conducted on the patient, the swinging plate is driven to swing under the action of a swinging part, and the swinging plate can be braked in the swinging process under the action of a braking part; when a patient is in an emergency during rehabilitation training, the swing plate is braked and stopped, and the possibility that the patient falls down during rehabilitation training is reduced.

The application discloses a kind of gold palladium-nitrogen doped carbon ribbon decorated g-C3N4 Nanosheet and its preparation method and application, UFR-NC is doped in g-C3N4 / To form g-C3N4 / UFR-NC composite nanomaterial;With g-C3N4 / UFR-NC composite nanomaterial as carrier, gold palladium shell core particle is loaded on g-C3N4 / UFR-NC composite nanomaterial to obtain gold palladium-nitrogen doped carbon ribbon decorated g-C3N4 Nanosheet.The gold palladium-nitrogen doped carbon ribbon decorated g-C3N4 Nanosheet of the application has multiple enzyme-like activities, good photocatalytic hydrogen production and hydrogen storage and release performance;At the same time, under the enhancement of 808 nm near-infrared light, it has multiple enzyme-like activities, high hydrogen storage and release performance.Oxidative stress damage in vivo can be reduced and neuroinflammation is inhibited, and in the treatment of Parkinson's disease, Alzheimer's disease, brain trauma, cerebral apoplexy and other microglia-mediated neuroinflammatory encephalopathy, there is obvious therapeutic effect.

This invention discloses an acute brain injury (TBI) prognosis detection system, comprising: a multi-source data synchronous acquisition and extraction section, a data preprocessing section, a machine learning prediction model, and an acute traumatic brain injury result display system. The system performs multi-source synchronous acquisition and extraction of 19-channel electroencephalogram (EEG) data distributed throughout the brain and data from the left and right middle cerebral arteries (MCA) under a mixed auditory evoked paradigm task. The system preprocesses clinical data, EEG, MCA, and Glasgow Outcome Scale (GOS) scores of TBI patients. The preprocessed data is then input into the machine learning prediction model, which calculates and outputs the probability of poor prognosis in TBI patients. The TBI patient poor prognosis prediction result displays the probability of poor prognosis in TBI patients. This invention enables early, simple, and accurate detection of acute brain injury (TBI) patients.

The invention relates to the technical field of medical health management, and discloses a craniocerebral trauma patient prognosis management method and system.The method comprises the steps that real-time physiological data of a patient are continuously obtained, and patient activity scene information corresponding to the real-time physiological data is synchronously obtained; according to a personalized rehabilitation plan set for the patient, monitoring whether the real-time physiological data in the rehabilitation plan deviates from a preset physiological response target range or not; when it is monitored that the real-time physiological data deviates from the preset physiological response target range, situation attribution judgment is conducted on the deviation situation of the physiological data based on the patient activity scene information and a preset attribution rule, and a situation attribution judgment result is obtained; and according to the situation attribution judgment result, generating an adjustment suggestion for the personalized rehabilitation plan. According to the method, the real-time physiological data of the patient and the activity scene information are deeply fused, and the situation attribution judgment is carried out, so that the dynamic adjustment of the personalized rehabilitation plan is realized.