31 results about "Cerebral trauma" patented technology

The invention relates to the technical field of extracranial strike testing, in particular to digitally-controlled extracranial strike construction equipment of a traumatic brain injury model. Comprising a test platform, a sliding rail installed on the test platform and arranged in the length direction of the test platform, an animal fixing platform slidably connected with the test platform through the sliding rail, an impact structure arranged on one side of the test platform and a driving structure used for driving the animal fixing platform to move towards the impact structure. The impact structure is fixedly connected to the test platform, the output end of the impact structure faces the animal fixing platform, an experimental animal is installed on the animal fixing platform, the driving structure drives the animal fixing platform to enable the experimental animal to actively impact, and the impact structure enables the experimental animal to impact a fixed acting point at a certain initial speed. The system is more in line with the injury mechanism of a patient with clinical actual craniocerebral trauma, and a tester can accurately control and monitor parameters according to the moving speed and the moving distance of the animal fixing platform.

The invention discloses a craniocerebral trauma prognosis prediction analysis system and method based on a three-dimensional model, and belongs to the field of medical care systems.The craniocerebral trauma prognosis prediction analysis method comprises the steps that a feature sequence reflecting the craniocerebral healing quality is obtained based on a patient craniocerebral three-dimensional model, and data reflecting the craniocerebral healing quality is obtained through data processing; according to the method, the healing quality is evaluated on the basis of the obtained feature sequence reflecting the craniocerebral healing quality, the features reflecting the craniocerebral healing quality are accurately obtained, the features of the craniocerebral healing quality are accurately analyzed, the situation of abnormal recovery is quickly and accurately found, the craniocerebral trauma recovery prediction accuracy is improved, and the risk of craniocerebral trauma recovery prediction is reduced. The problem that in the prior art, craniocerebral trauma recovery prediction is not high in accuracy is solved.

Methods, compositions and kits useful in the assessment and monitoring post traumatic brain injury (TBI) symptoms, including neurodegenerative and / or vascular dysfunction, based on detecting changes in measured blood levels of vWF, NRGN, FABP7, GFAP, BDNF, NSE and ST2.

The present invention belongs to the technical field of medicine. Disclosed are a class of magnolol / honokiol derivatives, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are magnolol / honokiol nitrone derivatives as represented by general formulas (I) and (II). Such derivatives are prepared by means of artificial synthesis. Further provided are a pharmaceutical composition containing same, and the use thereof against inflammation, against cerebral infarction, in the treatment of amyotrophic lateral sclerosis, and against cerebral trauma.

According to the application of simvastatin as a rehabilitation treatment medicine after cerebral trauma, the medicine acts on the subacute stage of cerebral trauma. The invention relates to a medicine for inhibiting the expression of an extension factor extremely long chain fatty acid protein 1 (Elongation OfVery Long Chain Chelin FattyAcids Like Protein ELOVL). The medicine can be used for inhibiting the expression of the Elongation OfVery Long Chain Chelin FattyAcids Like Protein ELOVL. The medicine improves the motor function recovery of the body after cTBI in the treatment of the cerebral trauma in the subacute stage, and inhibits the excessive activation of astrocytes and the formation of glial scars. The medicine is used for down-regulating ELOVL through an mTOR way.

The invention belongs to the technical field of biological medicines, and provides application of sodium tyrosol sulfate and a derivative tyrosol compound in preparation of brain health products. The structure of the sodium tyrosol sulfate and the derivative tyrosol compound is shown as a formula I. The sodium tyrosol sulfate and the derivative tyrosol compound can effectively reduce the infarction area after cerebral ischemia and relieve encephaledema caused by cerebral ischemia, and have wide application in the aspects of resisting cerebral ischemia and improving encephaledema and cerebral infarction caused by cerebral ischemia. Meanwhile, learning and memory abilities can be effectively improved, brain function recovery is promoted, and the traditional Chinese medicine composition can be widely applied to treatment of behavior / cognitive dysfunction diseases such as cerebral trauma, cerebrovascular accidents, Alzheimer's disease and Parkinson's disease. And the formula I of the # imgabs0 # is shown in the specification.

The invention relates to the technical field of gene engineering, in particular to a central nervous system cell specific miRNA expression vector, an adeno-associated virus vector and application thereof, the miRNA expression vector comprises an Ef1alpha promoter sequence, an induction sequence, a Tre promoter, a fluorescence labeling sequence, a tRNA sequence, a miRNA sequence and an SV40poly (A) termination signal sequence; and the gene sequence of the specific miRNA overexpression is a tRNA-miRNA-tRNA combined sequence doped at the downstream of the fluorescence labeling sequence. Experiments show that the miRNA expression vector can be stably overexpressed in specific cells. The carrier has the advantages of tracking the carrier and performing targeted therapy, and can be applied to treatment of central system neuroinflammation diseases, such as neurodegenerative diseases, cerebral hemorrhage, stroke, cerebral trauma and the like.

The present application discloses a system and method for predicting the prognosis of craniocerebral trauma based on a three-dimensional model, which belongs to the field of medical care systems. The present application obtains a feature sequence reflecting the quality of craniocerebral healing based on a three-dimensional model of the patient's craniocerebral, obtains data reflecting the quality of craniocerebral healing through data processing, evaluates the quality of healing based on the acquired feature sequence reflecting the quality of craniocerebral healing, accurately obtains features reflecting the quality of craniocerebral healing, accurately analyzes the features of the quality of craniocerebral healing, quickly and accurately discovers abnormal recovery, improves the accuracy of craniocerebral trauma recovery prediction, and solves the problem of low accuracy of craniocerebral trauma recovery prediction in the prior art.

The invention provides a cerebral trauma segmentation method based on deep semantic fusion, and the method comprises the steps: obtaining traumatic brain injury tissue data, and carrying out the preprocessing of sample data; designing a semantic coding module, and extracting semantic features of the sample data; a semantic segmentation module is designed to complete a semantic segmentation task, and an image fusion module is designed to assist semantic segmentation, so that the segmentation accuracy is improved; segmenting the region to be segmented; according to the method, depth semantic information of different modals in MRI is fused, the wound penumbra and the injury core area can be accurately segmented, the accuracy of the segmentation result is ensured, the use method is simple, the method has the advantages of being easy to implement, small in calculation amount and low in data size requirement, meanwhile, a method based on the same variance uncertainty is introduced, and the method has good application prospects. The weights of different modules are dynamically adjusted, so that the accuracy of model segmentation is improved.

The invention discloses a g-C3N4 nanosheet modified by a gold-palladium-nitrogen doped carbon ribbon as well as a preparation method and application of the g-C3N4 nanosheet. The preparation method comprises the following steps: doping UFR-NC into g-C3N4 to form a g-C3N4 / UFR-NC composite nanomaterial; the g-C3N4 / UFR-NC composite nanomaterial is used as a carrier, and gold-palladium core-shell particles are loaded on the g-C3N4 / UFR-NC composite nanomaterial, so that the g-C3N4 nanosheet modified by the gold-palladium-nitrogen doped carbon ribbon is obtained. The g-C3N4 nanosheet modified by the gold-doped palladium-nitrogen-doped carbon ribbons, disclosed by the invention, has multiple enzyme-like activities and good photocatalytic hydrogen production and hydrogen storage and release performance; meanwhile, under the enhancement effect of 808 nm near-infrared light illumination, the multi-enzyme activity is achieved, and the hydrogen storage and release performance is high. The traditional Chinese medicine composition can reduce oxidative stress injury in vivo and inhibit neuroinflammation, and has an obvious treatment effect on microglia mediated neuroinflammatory encephalopathy such as Parkinson's disease, Alzheimer's disease, cerebral trauma and cerebral apoplexy.

The invention provides a cerebral trauma semi-dark band image segmentation method and device, equipment, a medium and a product, and the method comprises the steps: obtaining at least two modal magnetic resonance images, inputting the at least two modal magnetic resonance images into a trained feature fusion module for fusion, and obtaining a fusion image; and inputting the fused image into a trained segmentation module for image segmentation to obtain a cerebral trauma semi-dark band region. According to the invention, the automatic identification of the cerebral trauma penumbra region is realized, and the identification efficiency of the cerebral trauma penumbra region is improved.

The invention provides an anesthesia device for emergency treatment of craniocerebral trauma. Relates to the technical field of medical anesthesia equipment. The emergency treatment anesthesia device for the craniocerebral trauma comprises a supporting frame, a medicament tank is fixedly installed on the supporting frame, a quantitative tank is fixedly installed at the bottom of the medicament tank, the medicament tank and the quantitative tank are communicated through a communicating pipe, an injection pump and an atomizer are arranged below the quantitative tank, and the atomizer is connected with the medicament tank through a connecting pipe. A liquid guide pipe is fixedly installed at the bottom of the quantitative tank, a two-branch pipe is fixedly installed at the bottom end of the liquid guide pipe, one end of the two-branch pipe is fixedly connected with a liquid inlet port of the injection pump, and the other end of the two-branch pipe is fixedly connected with a liquid inlet port of the atomizer. Intravenous injection and inhalation type anesthesia can be integrated, a single anesthesia mode or a combined anesthesia mode can be flexibly selected according to the real-time illness state of a patient, and anesthetic medicine mixing and diluting can be rapidly completed according to physical sign parameters of special crowds.

The invention discloses 2-sulfur-3-(piperidinedithio) phthalide (I), pharmaceutically acceptable salts thereof, a preparation method of the 2-sulfur-3-(piperidinedithio) phthalide (I), a pharmaceutical composition of the 2-sulfur-3-(piperidinedithio) phthalide (I) and application of the 2-sulfur-3-(piperidinedithio) phthalide (I) in preparation of drugs for treating and comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The present invention belongs to the technical field of rehabilitation equipment and specifically discloses an auxiliary exercise device and control method for early postoperative rehabilitation of patients with craniocerebral trauma. The device includes a bed, a surrounding mechanism, and a flexion-extension mechanism. The surrounding mechanism includes a bracket, a telescopic rod, a power source, and a rotating rod. The bracket is connected to the foot of the bed, and the telescopic rod is connected to the bracket and the power source. The power source controls the rotation of the rotating rod. The rotating shaft is provided with a clamping portion that can be engaged with the patient's toes. The flexion-extension mechanism includes a rotating plate, a cylinder, and an airbag. The rotating plate is hinged to the bed, and a baffle is provided on the side of the rotating plate. The cylinder is provided with a magnetic ring on the cylinder piston, and a permanent magnet that attracts the magnetic ring is provided on the rotating plate. The airbag is located on the rotating plate and the baffle. The cylinder contains gas, and the top and bottom of the cylinder are connected to the corresponding airbag. By adopting this technical solution, the surrounding mechanism and the flexion-extension mechanism are utilized to guide the patient's lower limbs to automatically perform ankle pump exercises to prevent deep vein thrombosis.

The invention discloses a multi-modal fusion portable cerebral trauma first-aid navigation system and method, and relates to the technical field of cerebral trauma first-aid navigation. The system comprises a handheld navigation device, a data acquisition module, a pose resolving module, a feature extraction module and a boundary recognition module. The handheld navigation equipment integrates a miniature ultrasonic probe and a 9-axis inertial measurement unit, a data acquisition module synchronously acquires intracranial ultrasonic echo sequence data and spatial motion parameters, and a pose resolving module resolves the spatial motion parameters in real time to determine real-time spatial pose data of the equipment in a head coordinate system. The feature extraction module inputs the ultrasonic echo sequence data into a pre-trained convolutional neural network model to output a multi-scale ultrasonic feature vector, and the boundary recognition module generates hematoma boundary dynamic labeling information in combination with the multi-scale ultrasonic feature vector and the real-time spatial pose data. The system is suitable for scenes of on-site first aid, patient transfer and the like, and assists medical staff in mastering the intracranial hematoma condition.

This invention provides a method and system for establishing a prognostic model for traumatic brain injury (TBI) based on multimodal data fusion and AI, belonging to the field of medical artificial intelligence technology. The method includes collecting patient clinical text and CT image data, performing preprocessing, extracting clinical text features and image data features, and constructing three major models: a TBI prognostic prediction model, a clinical model of the predictive efficacy of edema expansion on TBI prognosis, and a TBI cerebral edema expansion prediction model. The final output of the prognostic model prediction results includes patient risk stratification results, neurological function prognostic prediction results, and cerebral edema expansion prediction results. The system includes a data acquisition module, a data preprocessing module, a feature extraction module, a multimodal model construction module, and a result output module. This invention can accurately achieve risk stratification and prognostic prediction for TBI, effectively improving the accuracy and efficiency of diagnosis and treatment, reducing the risk of misdiagnosis and missed diagnosis, and providing strong support for improving patient prognosis.

The invention discloses a 3-(piperidine alkyl dithioalkyl) phthalide compound (I), pharmaceutically acceptable salts thereof, a preparation method thereof, a pharmaceutical composition thereof and application of the 3-(piperidine alkyl dithioalkyl) phthalide compound in preparation of drugs for treating and / or preventing nervous system related diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The invention discloses an amide alkyl thiol ketal compound (I), pharmaceutically acceptable salts thereof, a preparation method of the amide alkyl thiol ketal compound, a pharmaceutical composition of the amide alkyl thiol ketal compound, and application of the amide alkyl thiol ketal compound in preparation of drugs for treating and / or preventing nervous system related diseases and myocardial ischemia related diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic cerebral thrombosis, nerve injury caused by cerebral trauma, myocardial ischemic injury and other diseases;

The application discloses a kind of postoperative infection risk early warning system of craniocerebral trauma patient.The system uses "multimodal perception-privacy computing-interpretable early warning-closed loop intervention" four-layer integrated architecture, including multimodal perception and fusion module, privacy computing hub module, interpretable early warning engine and intelligent closed loop intervention module connected in turn.Communication connection is integrated millimeter wave radar, flexible sensor array and MS@SLET sensor chip in multimodal perception and fusion module, realize multidimensional data high-fidelity acquisition;Privacy computing hub module is based on improved FlexFair federated learning framework, and data privacy protection and group prediction fairness are considered;Interpretable early warning engine realizes accurate early warning and generates structured attribution report by the CNN-Transformer hybrid model of stage perception attention mechanism;Intelligent closed loop intervention module realizes hierarchical early warning, individualized scheme matching and model incremental optimization.The application solves the bottleneck of the prior art, such as insufficient timeliness of early warning, imbalance between data utilization and privacy fairness, uninterpretable decision and early warning intervention fragmentation, shortens the infection index detection time to within 30 seconds, the system response time is less than 200 ms, the infection-related mortality rate is reduced by 65.4%, fully meets the requirements of laws and regulations such as "Personal Information Protection Law", and has very high clinical application value.

The invention belongs to the technical field of rehabilitation equipment, and particularly discloses an auxiliary movement device for postoperative early rehabilitation of a craniocerebral trauma patient and a control method.The device comprises a bed body, a surrounding mechanism and a bending and stretching mechanism, the surrounding mechanism comprises a support, a telescopic rod, a power source and a rotating rod, and the support is connected with the bed tail of the bed body; the telescopic rod is connected with the support and the power source, the power source controls the rotating rod to rotate, and the rotating shaft is provided with a clamping part which can be clamped with the toe part of a patient; the bending and stretching mechanism comprises a rotating plate, an air cylinder and an air bag, the rotating plate is hinged to the bed body, a baffle is arranged on the peripheral side of the other end of the rotating plate, the air cylinder is arranged on the side edge of the rotating plate, a magnet ring is arranged on a piston of the air cylinder, and a permanent magnet attracted with the magnet ring is arranged on the rotating plate. The top and the bottom of the cylinder are communicated with the corresponding airbags. According to the technical scheme, the surrounding mechanism and the flexion and extension mechanism are used for guiding the lower limbs of a patient to automatically perform ankle pump movement, and deep venous thrombosis is prevented.

The invention discloses a 3-(piperidine alkyl sulfide or seleno) phthalide compound (I), pharmaceutically acceptable salts thereof, a preparation method thereof, a pharmaceutical composition and application thereof in preparation of drugs for treating and / or preventing nervous system related diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The invention discloses an acute cerebral trauma prognosis detection system, which comprises a multi-source data synchronous acquisition and extraction part, a data preprocessing part, a machine learning prediction model and acute traumatic cerebral injury result display, 19-lead electroencephalogram (EEG) data distributed in the whole brain and left and right cerebral middle artery (MCA) data are subjected to multi-source data synchronous acquisition and extraction under a mixed auditory induction normal form task, and clinical data, EEG, MCA and classification tag Grassco prognostic score (GOS) of a patient with cerebral trauma are subjected to data preprocessing; inputting the preprocessed data into a machine learning prediction model, and outputting the probability of poor prognosis of the TBI patient after calculation by the prediction model; the TBI patient reject ratio prediction result shows the probability of poor prognosis of the TBI patient. The method can be used for early, simply and accurately detecting the acute cerebral trauma patient.

The utility model relates to the technical field of medical equipment, in particular to a brain trauma postoperative rehabilitation protection device which comprises a headrest supporting pad, the upper end of the headrest supporting pad is fixedly connected with a first air bag, the other end of the first air bag is communicated with an air bag pad, and the outer wall of the air bag pad is communicated with a plurality of second air bags which are evenly distributed. The outer wall of the first air bag communicates with an annular limiting bag, the other end of the annular limiting bag is fixedly connected with a first bandage, the right end of the first air bag is fixedly connected with a supporting ring, and the other end of the first bandage penetrates through the supporting ring and is detachably connected with the outer wall of the first bandage through a hook-and-loop fastener. When the dressing is fixed, the dressing enters the first air bag, the air bag cushion, the second air bags and the annular limiting bag, so that the first air bag, the air bag cushion, the second air bags and the annular limiting bag can be tightly attached to the head of the patient, and the purpose of improving the dressing fixing stability in an air bag inflation mode is achieved.

The present invention provides a GFAP, NFL and UCH-L1 combined detection kit, comprising: an acridinium ester labeled antibody working solution and a magnetic bead coated antibody working solution; the acridinium ester labeled antibody working solution contains acridinium ester labeled GFAP, NFL and UCH-L1 antibodies, and the magnetic bead coated antibody working solution contains magnetic bead coated GFAP, NFL and UCH-L1 antibodies. By screening the components and the content of each component of the acridinium ester labeled working solution and the magnetic bead labeled working solution, a stable working environment can be provided for the acridinium ester labeled GFAP, NFL and UCH-L1 antibodies and the magnetic beads labeled with the GFAP, NFL and UCH-L1 antibodies, and specific recognition and detection of GFAP, NFL and UCH-L1 are achieved, thereby realizing the triple detection of GFAP, NFL and UCH-L1 for early diagnosis of patients with brain trauma.

The application belongs to the technical field of biological medicine, and provides application of tyrosol sodium sulfate and derivative tyrosol compounds in preparation of brain health products. The structure of the tyrosol sodium sulfate and the derivative tyrosol compounds is shown as formula I, which can effectively reduce the infarction area after cerebral ischemia, and reduce cerebral edema caused by cerebral ischemia, and has wide application in resisting cerebral ischemia and improving cerebral edema and cerebral infarction caused by cerebral ischemia. Meanwhile, the tyrosol sodium sulfate and the derivative tyrosol compounds can effectively improve learning and memory ability, promote recovery of brain function, and have wide application in treating behavior / cognitive dysfunction diseases such as brain trauma, cerebrovascular accident, Alzheimer's disease and Parkinson's disease. Formula I.

The invention discloses 3-(piperidine alkyl sulfenyl) benzyloxy phthalide (I), pharmaceutically acceptable salts thereof, a preparation method thereof, a pharmaceutical composition thereof and application of the 3-(piperidine alkyl sulfenyl) benzyloxy phthalide (I) in preparation of drugs for treating and / or preventing nervous system related diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The invention discloses an amine alkoxy nicotine compound (I), pharmaceutically acceptable salts thereof, a preparation method thereof, a pharmaceutical composition thereof and application of the amine alkoxy nicotine compound in preparation of drugs for treating and / or preventing nervous system diseases. Comprising but not limited to vascular dementia, Alzheimer's disease, frontotemporal dementia, Prion disease, dementia with Lewy bodies, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, cerebral arterial thrombosis, hemorrhagic stroke, nerve injury caused by cerebral trauma and other diseases;

The invention relates to the technical field of postoperative nursing, and discloses a craniocerebral trauma postoperative nursing device which comprises a base with an empty groove formed in the top, a swing plate rotationally connected to the inner side of the empty groove, two placement grooves formed in the top of the swing plate and symmetrically distributed, and a swing unit arranged on the base. The swing unit comprises a swing component arranged on the base and a brake component arranged at the top of the swing component, and the swing component comprises a swing assembly arranged on the base. According to the craniocerebral trauma postoperative nursing device, through the swinging unit, a swinging plate swings left and right on the inner side of an empty groove, a patient is driven to swing left and right, balance rehabilitation training is conducted on the patient, the swinging plate is driven to swing under the action of a swinging part, and the swinging plate can be braked in the swinging process under the action of a braking part; when a patient is in an emergency during rehabilitation training, the swing plate is braked and stopped, and the possibility that the patient falls down during rehabilitation training is reduced.

The application discloses a kind of gold palladium-nitrogen doped carbon ribbon decorated g-C3N4 Nanosheet and its preparation method and application, UFR-NC is doped in g-C3N4 / To form g-C3N4 / UFR-NC composite nanomaterial;With g-C3N4 / UFR-NC composite nanomaterial as carrier, gold palladium shell core particle is loaded on g-C3N4 / UFR-NC composite nanomaterial to obtain gold palladium-nitrogen doped carbon ribbon decorated g-C3N4 Nanosheet.The gold palladium-nitrogen doped carbon ribbon decorated g-C3N4 Nanosheet of the application has multiple enzyme-like activities, good photocatalytic hydrogen production and hydrogen storage and release performance;At the same time, under the enhancement of 808 nm near-infrared light, it has multiple enzyme-like activities, high hydrogen storage and release performance.Oxidative stress damage in vivo can be reduced and neuroinflammation is inhibited, and in the treatment of Parkinson's disease, Alzheimer's disease, brain trauma, cerebral apoplexy and other microglia-mediated neuroinflammatory encephalopathy, there is obvious therapeutic effect.

This invention discloses an acute brain injury (TBI) prognosis detection system, comprising: a multi-source data synchronous acquisition and extraction section, a data preprocessing section, a machine learning prediction model, and an acute traumatic brain injury result display system. The system performs multi-source synchronous acquisition and extraction of 19-channel electroencephalogram (EEG) data distributed throughout the brain and data from the left and right middle cerebral arteries (MCA) under a mixed auditory evoked paradigm task. The system preprocesses clinical data, EEG, MCA, and Glasgow Outcome Scale (GOS) scores of TBI patients. The preprocessed data is then input into the machine learning prediction model, which calculates and outputs the probability of poor prognosis in TBI patients. The TBI patient poor prognosis prediction result displays the probability of poor prognosis in TBI patients. This invention enables early, simple, and accurate detection of acute brain injury (TBI) patients.