12 results about "Hindbrain" patented technology

The invention discloses an adjustable maxillofacial region pressurizing and fixing device which comprises a longitudinal bandage, a transverse bandage and a lower jaw bandage. The longitudinal bandage is longitudinally wound on the head and detachably connected with the transverse bandage through the quadrilateral lock catch, and the transverse bandage is transversely wound on the forehead and the afterbrain; a band body of the longitudinal binding band is provided with a fixing device used for pressurizing the anterior parotid gland area of the ear, and the fixing device is in an oval shape and internally provided with a concave face. The longitudinal binding band is connected with the lower jaw binding band through the chin lock catch, the chin lock catch is tightly attached to the lower jaw, the lower jaw binding band is transversely wound on the lower jaw, and the lower jaw binding band is provided with the chin lock catch. The lock catches can be adjusted, medical pressurizing and fixing parts can be adjusted according to different surgical parts, and the problems that the head and the face are inconvenient to fix in the early stage and a traditional bandage is abraded are solved; a pressurizing fixing device is adopted and can be properly adjusted up and down, and a gauze roll can be placed in a concave surface to adjust the pressure; and the design of the chin lock catch and the chin lock catch is adopted, so that the whole body is more fit with the human face.

The present invention refers an in vitro method for inducing differentiation of human pluripotent stem cells (hPSCs) generating hindbrain neurons and compositions thereof. The invention also refers to the hindbrain neurons and compositions thereof for use in diagnostic screening and for use in the prevention and / or treatment of neurological disorders.

The application discloses a method for differentiating stem cells into caudal serotonergic neurons, a complete culture medium and application. Specifically, a new culture medium is formed by adding small molecule compounds, so that human pluripotent stem cells are gradually induced to obtain hindbrain neural stem cells, ventral hindbrain caudal neural stem cells, serotonergic precursor cells and caudal serotonergic neurons of the hindbrain. The culture method is simple, and can efficiently obtain mature serotonergic neurons of specific regions, thereby providing an effective cell model for research on diseases related to the serotonergic system.

Provided herein are methods of generating hindbrain cells, including respiratory hindbrain cells, from pluripotent stem cells. Also provided are methods of generating a three-dimensional organoid comprising a population of hindbrain cells including a heterogeneous population of interneurons.

The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells into hindbrain progenitor cells, enteric neural crest lineage cells, as well as differentiated hindbrain lineage or enteric neural crest lineage cells obtained by such methods. The presently disclosed subject matter also provides for uses of such cells for preventing and / or treating enteric nervous system disorders (e.g, Hirschsprung's disease), and for screening compounds suitable for preventing and / or treating enteric nervous system disorders (e.g., Hirschsprung's disease).

This invention discloses a trapezius muscle acupressure massage device. The trapezius muscle acupressure massage device of this invention, through its back-of-the-head and cervical spine placement parts formed by closely following the curves of the user's back of the head and neck, allows the user's head to remain in a naturally fixed state. Therefore, the piston of the trapezius muscle acupressure module can apply accurate and stable acupressure to the trapezius muscle, thereby relaxing and strengthening the muscles around the trapezius muscle. This promotes and activates blood circulation, and further enhances the therapeutic effect through acupressure, traction, and stretching that promote metabolism.

The invention discloses an electroacupuncture and PNF collaborative ACLR afterbrain limb integrated precise rehabilitation method and system, and relates to the technical field of clinical medicine rehabilitation treatment, and the method comprises the steps: S1, baseline function and iconography evaluation; s2, preparing center modulation; s3, peripheral motion driving is carried out; s4, quantitative acquisition and response evaluation; s5, performing parameter adjustment and periodic execution; according to the invention, quantified physiological and functional indexes are embedded as a closed-loop adjustment basis, so that the electroacupuncture parameters and PNF strength of each treatment can be optimized in a data-driven manner. Through periodical evaluation of clinical knee joint function scores, balance parameters, SEMG and central function activation and adjustment and intervention according to preset rules, the method realizes transformation from empirical rehabilitation to evidence-driven and individualized rehabilitation. According to the closed-loop design, benefits of individuals on intervention can be amplified, and adverse reactions or overload risks can be recognized in real time, so that the possibility of treatment side effects or function degradation is reduced.

A brain magnetic detector support comprises a main support and at least one sub-support, the sub-support can be adjusted relative to the main support, the position of each sub-support relative to the main support can be adjusted according to needs, brain magnetic detector installation portions are formed on the main support and the sub-supports respectively, and the main support and the sub-supports are connected through the brain magnetic detector installation portions. The brain magnetic detector mounting portions are arranged in a predetermined pattern. The brain magnetic detector support is provided and comprises a main support body covering the head top portion, a first sub-support body and a second sub-support body, and the first sub-support body and the second sub-support body can be adjusted or moved relative to the main support body to be attached to the cheeks and the afterbrain. During wearing, the first sub-support and the second sub-support are moved away from the main support, so that the whole support can be easily worn on the brain, and after wearing, the first sub-support and the second sub-support are adjusted to be close to cheeks and afterbrain, so that each brain magnetic detector borne on the main support and the sub-supports can be close to the head. Therefore, the measurement precision is improved.

The purpose of the present invention is to provide a method whereby hindbrain neural stem cells can be cultured over a long period of time while maintaining multipotency. The present invention relates to a method for manufacturing hindbrain neural stem cells, the method involving: a step for inducing differentiation of hindbrain neural stem cells from pluripotent stem cells; and a step for culturing the hindbrain neural stem cells by using a culture medium that contains a GSK3β inhibitor, a TGFβ inhibitor, and a BMP inhibitor and does not contain a basic fibroblast growth factor (bFGF).

The utility model discloses an adjustable height's pillow relates to pillow technical field, including pillow support, and the pillow support is divided out with human body pillow pad part corresponding neck support area, left side support area, right side support area and back brain support area, further, be equipped with neck support height adjusting unit for adjusting neck support height on neck support area, be equipped with side support height adjusting unit for adjusting side support height on left side support area and right side support area, be equipped with back brain pillow support height adjusting unit for adjusting back brain pillow support height on back brain support area. Through setting up corresponding adjusting unit, make every support area can realize individual height adjustment, satisfy the use demand of user, ensure when using the pillow, cervical vertebra is in the most comfortable state, effectively avoid the harm to cervical vertebra because of the discomfort of pillow height.

The invention belongs to the technical field of biological pharmacy, and provides application of glycyrrhizin in preparation of a medicine for treating white matter injury. Animal experiment results show that the HMGB1 inhibitor Gly can obviously improve rat WMI pathological changes, reduce rat brain white matter region HMGB1 expression, obviously reduce the number of rat brain white matter region NG2 + Olig2 + double positive cells and improve rat WMI afterbrain white matter region OLs differentiation disorder; the myelination disorder of the white matter region of the rat after WMI can be improved, and the number of myelination axons of the rat is obviously increased; and the learning ability and the spatial memory ability of the rats are improved. It is clear that Gly can inhibit expression of HMGB1, and an effective technical means is provided for treatment of white matter damage.

The present disclosure relates to a method for selective differentiation from pluripotent stem cells to hindbrain tissue, the method comprising a step of selective differentiation into hindbrain tissue, in which embryoid bodies formed from pluripotent stem cells are cultured in the presence of a hindbrain tissue induction medium containing endogenous WNT secretion inhibitors and WNT signaling agonists.