153 results about "Circadian rhythm" patented technology

In various examples, circadian rhythm-based data augmentation for drowsiness detection systems and applications are provided. Embodiments described herein may produce an estimated circadian rhythm for a test subject and / or vehicle driver or other machine operator or occupant, and use the pattern of that circadian rhythm to correct, confirm, calibrate, or otherwise augment drowsiness assessments derived from video image data. The position of a person in the context of their process C circadian cycle may be used as indication of their level of drowsiness. An estimated process C circadian cycle may be used to generate more accurate ground truth training data for training machine learning models, and may be used by real-time, in-vehicle drowsiness detection systems that infer driver drowsiness levels based on captured images. In various embodiments, a circadian rhythm drowsiness estimate may be used to correct, calibrate, augment, and / or replace a drowsiness score predicted by a machine learning model.

In various examples, circadian rhythm-based data augmentation for drowsiness detection systems and applications are provided. Embodiments described herein may produce an estimated circadian rhythm for a test subject and / or vehicle driver or other machine operator or occupant, and use the pattern of that circadian rhythm to correct, confirm, calibrate, or otherwise augment drowsiness assessments derived from video image data. The position of a person in the context of their process C circadian cycle may be used as indication of their level of drowsiness. An estimated process C circadian cycle may be used to generate more accurate ground truth training data for training machine learning models, and may be used by real-time, in-vehicle drowsiness detection systems that infer driver drowsiness levels based on captured images. In various embodiments, a circadian rhythm drowsiness estimate may be used to correct, calibrate, augment, and / or replace a drowsiness score predicted by a machine learning model.

The invention discloses a humanoid robot walking and running unified control method and system based on a biological rhythm, and belongs to the technical field of humanoid robots. Capturing human walking and running action data, and extracting rhythm features from frequency and phase time domains; constructing a rhythm generator based on the rhythm features extracted in the step 1; according to a strategy gradient method based on a constraint reinforcement learning algorithm, a walking and running unified control strategy is constructed, rhythm information generated based on a rhythm generator is adopted in the walking and running unified control strategy, then action-critic is used for training, a bionic motion control system Walk2Run under speed driving is jointly constructed, natural gait transition and frequency adjustment are achieved, and the walking and running unified control strategy is obtained. And meanwhile, the physical capacity limitation of the robot is met, and motion fluency and energy efficiency are improved. The problems that an existing humanoid robot does not achieve energy optimization of human walking during walking, and mobility of an existing data set has high requirements for the motion ability of the robot and is poor in generalization ability are solved.

The invention relates to the crossing field of computer technology and biomedical engineering, and discloses a miniaturized intelligent blood glucose monitoring and analyzing method integrating edge computing. The method comprises the steps that glucose concentration and time sequence multi-source physiological signals are collected through a wearable sensor; performing data segmentation and multi-modal feature alignment based on the circadian rhythm; inputting the features into a lightweight student model obtained through knowledge distillation for blood glucose prediction; and the reasoning frequency is adaptively adjusted in combination with a memory feedback mechanism. The system comprises a sensing unit, a preprocessing unit, a lightweight model execution unit and a risk early warning unit. While the prediction precision is guaranteed, the model is compressed to be within 150 thousand parameters, a 512 KB on-chip memory is adapted, and low-power-consumption and high-stability end-side continuous blood glucose monitoring and early warning are achieved.

The invention relates to the technical field of medical monitoring, in particular to a monitoring and early warning system for adverse reactions after vaccination, which comprises a circadian rhythm recognition module, an extreme value offset processing module, a stage reaction mapping module, an abnormal grade recognition module and a linkage path judgment module. According to the method, a cross matching relation between abnormal response and rhythm change is established through positioning of a day and night body temperature extreme value interval midpoint before and after inoculation and continuous tracking of a time axis coordinate change trend, and whether the abnormality has rhythm driving characteristics or not is judged through a time period alignment relation between abnormality occurrence time and a rhythm offset interval. According to the method, an early warning path identification chain is constructed, participation items are expanded to sequence trend change, rhythm structure axial displacement, abnormal signal coverage rate and other elements, the sensitive capture capability for potential risks of adverse reactions after vaccination is improved, and the linkage early warning output capability for time-structure dual abnormal performance is also enhanced.

The invention relates to the technical field of intelligent breeding, in particular to a dairy cow nutritional requirement dynamic evaluation method and system, and the method comprises the following steps: S1, calculating a circadian rhythm phase parameter; s2, establishing fiber-decomposing bacteria activity coefficients under different rhythm phases; s3, correcting the theoretical digestibility of the NDF in the roughage according to the activity coefficient of the cellulose-decomposing bacteria obtained in the S2; s4, calculating dynamic basic metabolism energy consumption for maintaining the body temperature and behavior activities in combination with data of an environment temperature and humidity sensor; s5, outputting the day and night distribution proportion of protein and energy substances; and S6, controlling a feed feeding time sequence according to the rumen pH fluctuation threshold value. By monitoring the day and night rhythm and rumen environment state of the dairy cow in real time and dynamically regulating and controlling the precise proportion and feeding time sequence of the fine and coarse feed, the feed utilization efficiency is effectively improved, high cooperation of nutrition supply and physiological needs of the dairy cow is guaranteed, and the production performance and breeding economic benefits of the dairy cow are improved.

The invention discloses an intelligent control method for an analgesia pump based on deep learning. The intelligent control method comprises the following steps: S1, acquiring multi-modal original signals of a postoperative patient and synchronously normalizing the multi-modal original signals; s2, removing artifacts and noise in the synchronous data, and performing interpolation compensation on missing data; s3, carrying out modal reliability weight distribution on the sensing sequence based on a Hemma optimization algorithm; s4, inputting the node set into a PainNet relation statistical network to generate a dynamic graph topological structure; s5, predicting the pain score of the patient in the future, and generating a low-dose high-frequency micro-pulse administration instruction; s6, according to the circadian rhythm of the patient, dynamically adjusting the edge weight and the administration interval of the PainNet network; and S7, when the pain score fluctuation exceeds the limit, triggering an emergency mode, quickly converging to the most conservative parameter combination, and outputting a safety locking instruction. According to the invention, the control accuracy and safety of postoperative analgesia are improved.

A circadian rhythm-based time-sharing repair formula and use thereof. A day composition focuses on anti-oxidation, stress resistance and energy metabolism to resist oxidative damage and enhance day vitality and provide long-lasting antioxidation protection. A night composition focuses on DNA repair, anti-inflammation and nerve relaxation to promote cell regeneration and repair and continuously support night repair. The composition of the day composition and the night composition designed according to the circadian rhythm of human metabolism causes the corresponding activities to take effect at the best time, and components are designed to cooperate with each other according to different physiological needs during the day / night, which can greatly improve the anti-aging effect.

The invention relates to the technical field of air traffic management, and discloses an in-post controller fatigue prediction method based on a work type and a circadian rhythm, and the method comprises the steps: obtaining a face video frame in a controller post, and carrying out the calculation to obtain a PERCLOS time sequence representing an eyelid closing proportion; obtaining an exogenous factor related to the control task; the PERCLOS time sequence and the ectogenic factors are coded and input to a trained time sequence neural network model, and the time sequence neural network model is configured to apply different weights to the work types, the circadian rhythms and the work requirements so as to carry out differential modeling; and generating a fatigue level curve covering a preset prediction time window based on the output of the time sequence neural network model. The invention aims to solve the technical problems that a fatigue monitoring method in the prior art is lagged in response and insufficient in adaptability to dynamic working scenes, and provides a method capable of actively and accurately predicting the future fatigue development trend of the controller.

A wearable device may include a biofluid generation unit, a microfluidic channel for transporting the biofluid, and a sensing module including one or more electrochemical aptamer-based sensors having attached reporters that are displaceable by a target analyte. A wearable device may include electrodes for producing a potential sufficient for exchanging charged particles with the displaced reporters. A wearable device may include a processor for executing computer readable instructions including causing activation of the electrodes to exchange the charged particles with the displaced reporters, receiving a measurement of the exchanged charged particles, determining a concentration of the target analyte in the biofluid based on the received measurement, detecting a circadian rhythm based on the determined concentration; and generating an individualized set of circadian entraining factors based on the detected circadian rhythm to guide a user towards an improved circadian rhythm.

The invention discloses a ctEVs separation and analysis method with time resolution capability and application thereof. The ctEVs separation and analysis method comprises the following steps: S1, culturing cells by adopting glycometabolism markers; or injecting the animal by adopting a glycometabolism marker; step S2, manufacturing a fishbone-shaped micro-fluidic chip modified by streptavidin; s3, separating and analyzing the new tumor source extracellular vesicles by the micro-fluidic chip, and co-incubating the extracellular vesicles and the aptamer probe co-modified by Biotin and DBCO to realize biotinylation of the new tumor source extracellular vesicles; the aptamer probe is a heterologous multivalent aptamer probe; step S4, capturing biotin-labeled target extracellular vesicles by adopting a chip; and S5, acquiring a chip image by using a fluorescence microscope, and analyzing the concentration of the target extracellular vesicles in the sample according to a fluorescence signal. The method can be used for screening tumor circadian rhythm markers and the like.

A circadian phase adjustment method, system and device, and a storage medium, the method comprising: acquiring circadian phase information of a user, including target sleep time and target wake time of a target day; obtaining a target value of rhythm phase shift of the target day based on the target falling-asleep time and the target awakening time; a target cumulant of the light dose cumulant is obtained based on the target value of the rhythm phase migration by using a phase prediction model, and the phase prediction model is a relation model of the rhythm phase migration and the light dose cumulant; acquiring an actual cumulant of the light dose cumulant based on the light environment information; and judging whether the actual cumulant of the user at the current detection moment meets the requirement or not based on the target cumulant, and executing the light intervention operation if the actual cumulant does not meet the requirement. According to the method, the target value of the light dose cumulant required by the user on the target day is quantified, intervention is performed based on the actual light dose cumulant, and the accuracy of circadian rhythm phase adjustment is improved.

This invention belongs to the technical field of sleep quality analysis, specifically relating to a sleep quality analysis system and method based on sensors in a medical bed, to address the technical problem of existing methods relying too heavily on duration statistics while neglecting the continuity and circadian rhythm of sleep. The analysis method includes: S1, acquiring vital sign signal data collected by sensors in the medical bed within a sleep cycle and dividing it into multiple continuous time segments; S2, extracting physiological indicators such as respiratory rate, heart rate, and body movement amplitude within each time segment, and calculating the variability depth of the corresponding time segment; S3, generating a variability depth baseline; calculating non-steady-state disturbance factors based on the frequency and duration of micro-awakening disturbance segments; and S4, generating a comprehensive sleep quality score. The analysis method of this invention improves the comprehensiveness and objectivity of the assessment results, more realistically reflecting sleep health status.

The purpose of the present disclosure is to provide a device and a method for easily deriving the sleep quality of a user.　In a server 100 of the present disclosure, a log acquisition unit 103 acquires log information of a portable terminal 200 (user terminal) which is used by a user. On the basis of the log information, an estimation unit 108 estimates a user situation (sleep time, terminal use situation immediately before bedtime, sleep environment, circadian rhythm, etc.) that affects sleeping. Then, the estimation unit 108 estimates (corresponding to deriving) the sleep quality of the user on the basis of the user situation.

The present invention provides a package of a micronutrient supplement for promoting the digestive function of the intestinal tract of a body, the micronutrient supplement consisting of two types of unit dosage forms in one package for sale to a purchaser wherein the first type of unit dosage form contains VB6 and a compound thereof, and the second type of unit dosage form contains VB6 and a compound thereof. The first type of unit dosage form contains Zn and compounds thereof, the second type of unit dosage form contains Zn and compounds thereof or VD and compounds thereof, and the first type of unit dosage form does not contain Zn and VD, and the second type of unit dosage form does not contain VB6, the micronutrient supplement being provided in a manner of administration twice a day, the first type of unit dosage form is taken in an awakening period, and the second type of unit dosage form is taken in a sleep period. The packaging product can be matched with the biological clock rhythm of an organism, the absorption and utilization rate of micronutrients is increased, and then the intestinal digestion function is improved.

The application relates to a compound medicine for delaying skeletal muscle aging and application thereof, and the medicinal active components in the compound medicine composition are composed of menadione bisulfite sodium and N-acetyl cysteine, and belong to the technical field of biological medicine. A novel drug combination mode is developed, an oxidant menadione bisulfite sodium (MBS) and an antioxidant N-acetyl-L-cysteine (NAC) are combined and given in different time periods to regulate the H2O2 circadian rhythm of the skeletal muscle of old mice, the changes of the muscle strength, histopathology and aging marker protein level of the skeletal muscle of the old mice are detected, and then the precise compound medicine capable of improving the skeletal muscle function of the old mice and delaying skeletal muscle aging is determined. The application provides an effective drug combination strategy for relieving or treating the delay of skeletal muscle aging, and has very significant meaning.

A testing device and testing method of a hydrocephalus shunt valve. It relates to the technical field of medical device testing. The long-term reliability and adaptability of the shunt valve can be simulated in a complex physiological environment. The testing device of the hydrocephalus shunt valve comprises a controller, a body position simulation device, an ICP pressure chamber, an IPP pressure chamber, a backflow pump, a flow sensor and a circulating pipeline. The body position simulation device comprises a support, a pair of long arms simulating the human torso and a pair of short arms simulating the human head and neck, and a motor one driving the pair of long arms to swing and a motor two driving the pair of short arms to swing. The present application combines the in-vitro hardware testing platform with different patient physiological models, can reproduce physiological characteristics such as basic body position posture change, body temperature circadian rhythm fluctuation and long-term applicability, and realizes the in-vitro testing of the shunt valve quickly, at low cost and with high authenticity. The present application can quantify the performance of the shunt valve in a real physiological environment.

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl}oxy)acetamido]benzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMAL1 interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

An example computing device includes a memory; and one or more processors coupled to the memory, the one or more processors being configured to: determine a baseline circadian pattern of blood pressure for a patient over a first period of time; determine a subsequent circadian pattern of blood pressure for the patient over a second period of time, the second period of time being after the first period of time; determine one or more differences between the subsequent circadian pattern and the baseline circadian pattern; determine, based on the one or more differences between the subsequent circadian pattern and the baseline circadian pattern, whether the patient is a candidate for denervation therapy; and output, responsive to determining whether the patient is a candidate for the denervation therapy, an indication of whether the patient is or is not a candidate for the denervation therapy.

The invention relates to an effect of an REV-ERBalpha agonist SR9009 in the aspect of delaying ovarian senescence, and aims at the problem of fertility decline caused by cliff-type decline of ovarian functions of women over 35 years old, the SR9009 is applied to activate an REV-ERBalpha circadian rhythm signal channel in ovarian tissues, inhibit excessive autophagy of granular cells and maintain a primordial follicle dormancy state, so that the agonist SR9009 can be used for delaying ovarian senescence. Therefore, the original follicle depletion speed is delayed, follicle storage is maintained, and the ovary reproductive function cycle is prolonged. The effect is verified by a mammal model: REV-ERBalpha protein expression in an ovary of an aging individual is reduced, rhythmicity expression is disordered, autophagy of granulosa cells can be effectively inhibited in the ovary of the aging individual intervened by the SR9009, and the number of residual primordial follicles and the number of total follicles are obviously greater than those of an untreated control group. The invention provides an innovative treatment strategy of targeted rhythm regulation and control for clinical intervention of ovarian aging.

The present application relates to a kind of circadian rhythm-based circulating water aquaculture fish pond dissolved oxygen mechanism modeling method, including the influence of fish respiration consumption, water surface atmospheric reoxygenation, circulating water flow, mechanical aeration factor on dissolved oxygen dynamic change;According to oxygen transfer equation, considering the influence of the above four factors on fish pond dissolved oxygen, the dissolved oxygen mechanism model of circulating water aquaculture fish pond is established;Combined with oxygen transfer equation and the characteristics of fish respiratory activity changes between day and night, the influence of fish respiratory circadian rhythm on the model is analyzed, and the model is verified.The present application can more accurately reflect the high and low peak value in different time periods and also capture the dynamic changes presented in the whole cycle, and effectively avoid the loss and risk caused by the inaccurate model description to the aquaculture industry in extreme breeding environment or abnormal environment.

A method for estimating adaptation of a circadian rhythm of a user, the method comprising: measuring a circadian phase of the user by using at least one of a skin temperature sensor, a cardiac activity sensor, and a motion sensor; measuring a sleep-wake rhythm of the user by using at least one of the cardiac activity sensor and the motion sensor, and detecting a change in the sleep-wake rhythm of the user based on the measurement; determining a setpoint phase of a circadian phase based on the altered sleep-wake rhythm; determining a target day and night phase based on the position of the user; determining a diurnal adaptation rate based on a first adaptation rate if the setpoint phase and the target phase are in the same direction with respect to the current diurnal phase, and determining a diurnal adaptation rate based on a second adaptation rate if the setpoint phase and the target phase are in opposite directions from the current diurnal phase, wherein the second adaptation rate is smaller than the first adaptation rate; and outputting, via an interface, a derived parameter of the determined circadian adaptation or the calculated circadian adaptation to be presented to a user.

Targeting mitochondrial function is a strategy for preventing metabolic disorders, but restoring mitochondria diurnal regulation remains to be explored. Using targeted metabolomics, we identified 24-hour mitochondrial rhythms promoted by nocturnal time-restricted feeding (TRF) in mice fed a high-fat diet (HFD). Preceding its metabolic benefits, TRF promoted mitochondrial daily rhythms by converging on the enzyme dihydroorotate dehydrogenase (DHODH), which coordinates pyrimidine biosynthesis and mitochondrial oxidative metabolism. The inhibition of DHODH activity by the short half-life inhibitor BAY-2402234 modulated mitochondrial oxidative metabolism, thereby preventing diet-induced obesity, but only when injected at the transition between night and day. This timed inhibition of DHODH promoted oscillations in mitochondrial metabolic pathways and oscillations in the CoQ / CoQH2 ratio, improving metabolic adaptation to the HFD challenge. Our results highlight the role of mitochondrial daily rhythms in the pathophysiology of obesity and open avenues for chronopharmacological treatments targeting these rhythms. Thus, the present invention pertains to a method for treating or preventing obesity in a subject in need thereof. This method includes administering to the subject, at a specific time of the circadian rhythm, a therapeutically effective amount of a dihydroorotate dehydrogenase inhibitor that exhibits an inhibitory duration of less than 24 hours, and more specifically, a short half-life of less than 24 hours.

In the present invention, a rhythm estimation unit (105), using a prediction formula created based on the phase response curve of a circannual rhythm, estimates the circadian rhythm of a subject from: changes in biological information throughout a day of the subject, measured by a body temperature sensor (101); a light stimulation time, which is the time at which a light stimulation state is determined by a first determination unit (103); and an awakening time, which is the time at which an awakening state is determined by a second determination unit (104), where the estimation is made for the day after the changes in biological information of the subject is measured by a body temperature sensor (101). The rhythm estimation unit (105) outputs the estimated circadian rhythm. The outputted circadian rhythm is displayed on a display unit (107), for example.

The invention provides an illumination system arranged to illuminate a space for rearing a flock of birds, wherein the illumination system comprises: a visible light source configured to emit visible light; an ultraviolet light source configured to emit ultraviolet light; a controller configured to: (i) entrain a circadian rhythm of the flock of birds by controlling the visible light source to emit the visible light for a predetermined period of light, and not to emit the visible light for a predetermined period of dark; (ii) control the ultraviolet light source to emit the ultraviolet light at an ultraviolet light intensity for at least one subperiod within the predetermined period of dark, wherein the ultraviolet light comprises a peak wavelength within the UV-A wavelength range.

The invention belongs to the technical field of biology, and relates to regulation and control of a recent rhythm cycle of soybeans, in particular to application and a method of a GmCRY2a gene in regulation and control of the recent rhythm cycle of the soybeans. According to the research of the invention, two GmCRY2a genes in soybean are knocked out, and a delayed phenotype appears in a recent rhythm period. According to the CRISPR / Cas9 knockout technology constructed by the invention, pure and gmcry2a1a2 mutant soybean plants can be obtained, compared with control soybeans, the recent rhythm of the soybeans is obviously delayed, and the CRISPR / Cas9 knockout technology can be applied to screening of the soybeans suitable for multi-latitude region growth and has a huge application prospect.

A method for detecting a circadian rhythm of a user, the method comprising: acquiring measurement data indicative of a sleep time of the user, and determining a sleep-wake rhythm of the user based on the measurement data; determining a first phase value based on a sleep-wake rhythm, acquiring skin temperature measurement data for at least one 24-hour measurement period; the skin temperature measurement data is fitted to a cosine waveform and an evaluation of the fitting quality is performed and a second phase value is determined based on the fitting if the quality is above a threshold, a diurnal phase of the user is determined based on a combination of the first phase value and the second phase value if the fitting quality is above a threshold, and a diurnal phase of the user is determined based on a combination of the first phase value and the second phase value if the fitting quality is below a threshold. Determining a diurnal phase of the user based on the first phase value and not based on the second phase value; and outputting the calculated diurnal phase or a parameter derived from the calculated diurnal phase via an interface to present to a user.

The application discloses a method for identifying Klebsiella pneumoniae gene circadian rhythm expression by using a bioluminescence reporting system. The application constructs a recombinant bioluminescence Klebsiella pneumoniae driven by a metabolic gene malate:quinone oxidoreductase mqo promoter (Pmqo), and directly observes the change rule of bacterial gene expression under entrainment and free-running conditions of temperature cycle by monitoring the luminescence characteristics. The luxCDABE gene operon comprises genes for coding luciferase and substrate synthesis enzyme, wherein luxA and luxB code for heterodimer luciferase, luxC, luxD and luxE synthesize aldehyde as a substrate for the luciferase luminescence reaction. The luciferase catalyzes the oxidation of aldehyde to generate visible blue-green light with a wavelength of 450-490 nm. The Lux bioluminescence reporting system has the advantages of not needing to add an exogenous substrate and not affecting the normal physiological functions of the host, and can be applied to the identification of Klebsiella pneumoniae gene circadian rhythm expression.

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl)oxy)acetamidolbenzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMALl interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

The application discloses a method and system for monitoring light and sleep and improving sleep and circadian rhythm, and aims at the problems of single application scene and function, lagging theory and lack of deep analysis in existing sleep intervention methods, adopts sleep monitoring and light improvement services based on the non-visual effect theory of light, forms the cyclic regulation and feedback of sleep and light monitoring, analysis and evaluation and sleep intervention guidance, guides users to select appropriate lighting lamps, light exposure time and total amount, utilizes light which is strong synchronization and non-contact to improve the circadian rhythm and sleep of personnel, and thus the system can be suitable for the sleep habits of each user and keep a stable circadian rhythm.