The present disclosure relates to a device
assembly and a method for treating
heart failure by normalizing
elevated blood pressure in the
left atrium of a heart of a
mammal. Disclosed herein is a transcatheter
interatrial septum excision device
assembly configured to create a sized interatrial aperture between the right and left atria of a heart for the relief of elevated
left atrial pressure. The device
assembly comprises a delivery
catheter, a tissue stabilizer attached to a first
catheter having a central lumen and a penetrating tip that permits passage of a guidewire, and a cutter attached to a second
catheter having a central lumen that permits passage of the first catheter. Alternative configurations comprise a (third) catheter having a central lumen that permits passage of the aforementioned components to and from the
right atrium, a tissue retention mechanism and an optional coaxial alignment mechanism.