Embodiments include
heart monitoring systems, apparatus, and methods adapted to detect
myocardial ischemia. An apparatus includes at least one first-tier sensor / analyzer adapted to sense a first input related to cardiac function, and to produce a first-tier trigger
signal when the first input indicates
myocardial ischemia. In an embodiment, a first-tier sensor / analyzer includes an ECG sensor / analyzer. In another embodiment, a first-tier sensor / analyzer includes a patient activator. An apparatus further includes at least one second-tier sensor / analyzer adapted to sense a second input related to cardiac function, and to produce a second-tier trigger
signal when the second input indicates
myocardial ischemia. In an embodiment, a second-tier sensor-analyzer includes a heart sound sensor / analyzer. A triggering element is adapted to produce a response-invoking
signal in response to the first-tier trigger signal and the second-tier trigger signal. The response-invoking signal may invoke a patient alert, a message to an external
system, and / or a cardiac stimulus.