1549 results about "Biological body" patented technology

The AI-enhanced cellular modeling and simulation platform is a computational system designed to enhance biomedical research and development and personalized medicine and wellness. This platform integrates simulation modeling, machine learning and artificial intelligence, multi-omics data, and sophisticated data fusion and decision-support techniques to create comprehensive models of cellular systems and processes across multiple scales. It enables researchers and clinicians to simulate complex biological interactions, predict disease progression, and design or optimize treatment strategies or medical devices with improved accuracy and efficacy. The system's architecture allows for integration of various components, including real-time data processing, federated learning, and quantum computing enhancements. From personalized drug discovery and cancer therapies to synthetic biology and epidemiological analysis, this platform offers powerful tools for understanding and manipulating cellular systems and bioengineered systems. By bridging the gap between molecular-level interactions between cells and materials and organism-wide effects, it enables significant advancements in healthcare and biological sciences.

The invention discloses a multi-scene internet of things off-site dynamic inspection self-adaptive monitoring system, and relates to the technical field of intelligent inspection and path planning, the system is composed of a plurality of functional modules, and the system comprises a moving object detection module for detecting a moving object by adopting a Gaussian mixture background modeling and optical flow method; meanwhile, a light-weight MobileViT-XXS model is deployed, and a moving object target is tracked; the moving object classification and identification module is used for judging the type of a moving object through a multi-modal classification decision tree: when the moving object is judged to be a non-living body, carrying out ROI extraction and optimal frame interception on the image saliency of the moving object, and generating EXIF metadata through super-resolution reconstruction; when the judgment result is a biological object, biological category judgment is carried out: when the judgment result is an animal, geo-fencing data matching is carried out, and a spatial-temporal feature fusion model is adopted; and when human beings are judged, face quality evaluation is carried out through multi-frame fusion super-resolution.

The invention relates to the technical field of intelligent control, in particular to a rhythm adjustment illumination parameter control method and system. The system comprises the steps of collecting biological sign data and environment illumination data of a user through an intelligent wearable sensor, analyzing state differences in all biological rhythm modes according to the biological sign data, performing feature interaction on the environment illumination data and the state differences in the biological rhythm modes, generating illumination-mode state evaluation interaction feature data, and analyzing the illumination-mode state evaluation interaction feature data according to the illumination-mode state evaluation interaction feature data. Constructing an illumination demand mapping relation of the biological rhythm mode through a decision tree algorithm and the illumination-mode state evaluation interaction feature data, and performing learning optimization to generate an optimized rhythm mode illumination demand decision tree model; and transmitting the instant biological rhythm mode to the optimized rhythm mode illumination demand decision tree model to analyze the intelligent rhythm illumination demand data so as to execute rhythm adjustment illumination parameter control operation. According to the invention, dynamic intelligent illumination adjustment control based on the instant biological rhythm mode of the user is realized.

The invention relates to the field of biological medicine, and provides a cytokinetic analysis method, which is characterized in that a plurality of sections are registered to obtain a plurality of registered sections, the plurality of sections belong to the same tissue, and the plurality of registered sections are located in the same space coordinate system; constructing a three-dimensional model of the tissue on the basis of the space coordinate information of each slice in the plurality of registered slices; and performing kinetic analysis on the tissue based on the three-dimensional model, wherein the kinetic analysis comprises at least one of morphological analysis and geometric analysis. By utilizing the method, three-dimensional kinetic analysis of tissues or organs of an organism can be realized based on continuous slicing.

The invention relates to the technical field of medical instruments, and discloses an implantable neural electrode for long-term electrophysiological signal monitoring and a preparation method and application thereof. The neural electrode comprises an upper hydrogel insulation packaging layer, a lower hydrogel insulation packaging layer, an electrode site, a connecting line and a bonding pad, wherein the electrode site, the connecting line and the bonding pad are arranged between the upper hydrogel insulation packaging layer and the lower hydrogel insulation packaging layer, and the electrode site and the bonding pad are connected through the connecting line. The electrode sites, the connecting lines and the bonding pads are made of conductive hydrogel; the upper hydrogel insulation packaging layer and the lower hydrogel insulation packaging layer are made of insulation polymers and hydrogel. The insulating polymer is a plasma surface-modified insulating polymer. The preparation method of the neural electrode is simple and efficient, biotoxic materials are not introduced in the preparation process, good biocompatibility is achieved, continuous monitoring in a living body can be achieved for one year, important application value is achieved for studying signal response and neural circuits of all brain regions, and a beneficial tool is provided for long-term in-vivo monitoring.

The present invention, among other things, provides technologies for detecting and / or quantifying nucleic acids in cells, tissues, organs, or organisms. Pre-designed barcodes are associated with specific molecular targets through sequential hybridization experiments. A pseudo-color based barcoding scheme is described that overcomes the limitations in the previous generation of the technology. The current method can be applied to both in vitro and in situ analysis.

A bioenergy generator to increase the life force of a biological system is provided. The bioenergy generator includes fine pieces of natural stone, fine pieces of natural sand, fine pieces of metal, water and a supporting material operable to hold the natural sand, the natural stone, the metal, and the water together. Uses of the bioenergy generator are also provided, in particular, to enhance natural healing ability of a biological body and to treat a disease in a mammal, and to mitigate side effects of cancer treatments.

The invention discloses a near-infrared fluorescent probe for detecting ONOO <-> as well as a preparation method and application of the near-infrared fluorescent probe, and belongs to the technical field of peroxynitroso ion detection. The near-infrared fluorescent probe for detecting ONOO <-> provided by the invention is high in detection speed, and the highest fluorescence intensity can be reached within 60 seconds; the reaction is obvious and easy to observe, when the compound reacts with ONOO <->, strong red fluorescence can be generated, and the change of the color of the solution can be observed by naked eyes; the selectivity is strong, the sensitivity is high, the interference of other biological molecules and active substances can be effectively avoided, the accuracy and the reliability of a detection result are ensured, and the lowest detection limit can reach 107nM; the hydrogel has good biocompatibility, is low in toxicity in a living body, and does not generate adverse effects on normal physiological functions of a biological sample; the provided preparation method is simple and easy to operate, the raw materials are low in cost and easy to obtain, the synthesis efficiency is high, and the preparation method can be used for large-scale industrial production and has wide application prospects.

A method for propagating living organisms, especially plants, fungi, insects, and / or aquaculture, comprising the following steps: A Provision of an explant (120) of a living being; C In-vitro uptake of the explant (120) into a medium forming an in-vitro cell cluster, D1 Cloning of the in-vitro cell cluster using a cloning starter material and / or E Rooting and / or incubation of the cloning start material, wherein, in the course of the process, the identification of a location of an organism and / or a part of an organism from which the explant was provided is carried out as a data set, and that at least one process parameter for adjusting the growth conditions in the preceding and / or subsequent steps is controlled based on the identified data set; and an apparatus (100) for carrying out the process.

A Method for building a digital twin for a living system, whereas such a system is an organism, preferably a plant, an algae, a water-borne animal, a fungus, and / or a worm, wherein A Provision of a number of multiple living systems of the same type; B Growing the living systems of the same type under different growing conditions; C Determination of one or more parameters of the living system that is or are subjected to a change in over the time period of the growth; wherein multiple data sets are determined and stored, each data set has said parameter or parameters and a time stamp of the time of determination; and D Generation of a digital twin for said living system based on said multiple data set representing different growth stages of said living system.

The invention relates to an X-ray fluoroscopic image generation method and device and an X-ray fluoroscopic examination system. The generation method comprises the steps that a target sight vector for a target organ is determined according to observation requirements and the target position where the target organ of a living body needing to be detected is located; determining a primary rotation angle and a secondary rotation angle of an imaging arm in the X-ray fluoroscopy equipment based on the target sight line vector, and determining a primary rotation matrix and a secondary rotation matrix; determining a target projection matrix conforming to a target projection geometrical relationship based on the primary rotation matrix and the secondary rotation matrix; and based on the target projection matrix and pre-acquired three-dimensional computed tomography (CT) data of the target organ, performing volume rendering to obtain a two-dimensional target X-ray perspective image under the target observation view angle. According to the generation method and device of the X-ray perspective image and the X-ray perspective inspection system, the X-ray perspective image under the expected observation view angle can be freely generated based on the three-dimensional CT data obtained in advance.

The invention relates to a three-dimensional reconstruction method, system and device of a supporting structure and a storage medium. The method comprises the following steps: acquiring two-dimensional medical images of a support structure implanted in a lumen of a living body at different visual angles; performing image segmentation on a target support in the two-dimensional medical image under each view angle to generate a two-dimensional target image corresponding to each view angle; performing parametric deformation on the original three-dimensional grid of the target support through a deformation model based on a graph neural network to generate a deformed three-dimensional grid; projecting the deformed three-dimensional grid according to a virtual camera pose parameter corresponding to the two-dimensional medical image under each view angle, and rendering to generate a two-dimensional rendered image corresponding to each view angle; and iteratively optimizing the three-dimensional grid according to an error between the two-dimensional rendering image corresponding to each view angle and the two-dimensional target image, and stopping iteration when a preset termination condition is met so as to output an optimal three-dimensional grid. According to the invention, the precision of three-dimensional reconstruction of the support structure can be improved.

The spliced sleep deprivation mouse cage comprises a plurality of square cage bodies, a tray and a food box, the square cage bodies are transparent structural members, the top of each square cage body is provided with an organism inlet and at least one square notch, and the square notches are formed in the side edges of the square cage bodies. A plurality of water leakage holes are evenly formed in the bottoms of the square cage bodies at intervals, clamping grooves are formed in the tray, the square cage bodies can be spliced and embedded into the clamping grooves, circulation gaps are formed between the bottom walls of the square cage bodies and the inner bottom wall of the tray, and a water injection opening is formed in the side wall of the tray. When the sides, provided with the square notches, of any four square cage bodies are spliced, a containing groove communicated with the four square cage bodies is formed, and the food box is arranged in the containing groove. The spliced sleep deprivation mouse cage can effectively deprive the sleep of the mouse, the problems of poor sleep deprivation and wire entanglement caused by mixed feeding of the mouse are avoided, the water level height in each mouse cage is ensured to be consistent, and meanwhile, the water quality is convenient to replace.

An implant and an implant system. The implant is used for being implanted into a target part in a living body. The implant comprises a stent (100). The stent (100) is used for being provided at the target part to ameliorate physiological functions of the living body, the stent (100) comprises a cylindrical main body (110) made of a metal material, an opening (130) is provided on the peripheral surface of the cylindrical main body (110), and the opening (130) extends over at least a portion of the length of the cylindrical main body (110). The implant facilitates smooth transmission of wireless signals.

According to the invention, the multi-mode time-frequency domain conversion and the deep learning technology are combined, and a multi-component mixed Raman spectrum unmixing method is developed, so that clinical in-vivo and in-situ detection and disease diagnosis of novel Raman probes, instruments and the like are facilitated. The method comprises the following steps: (1) converting a mixed Raman spectrum from a time domain to a frequency domain by using fast Fourier transform (FFT), discrete cosine transform (DCT) and discrete sine transform (DST), and extracting frequency domain features; (2) extracting multi-scale local time-frequency domain characteristics of the mixed spectrum by using short-time Fourier transform (STFT) and discrete wavelet transform (DWT); (3) carrying out spectral unmixing calculation in each mode in combination with a one-dimensional attention mechanism U-shaped neural network model; and (4) fusing various modal unmixing results by using a meta-learning method, and analyzing the weight of each modal to obtain an accurate unmixing spectrum. Compared with a traditional Raman spectrum analysis method, the Raman spectrum multi-component signal unmixing method based on multi-modal time-frequency domain transformation and deep learning can accurately separate independent Raman signals of different tissue structures and biochemical components in a complex environment in a living body, so that the unmixing accuracy of the Raman spectrum multi-component signal is improved. Therefore, convenience is provided for subsequent disease mechanism analysis and diagnosis. The method provides an innovative and potential solution for in-vivo and in-situ detection analysis and disease diagnosis of medical clinical Raman spectroscopy.

According to the implantable animal data detector and the detection method thereof provided by the invention, the main body and the sealing cover which are in threaded connection are adopted to seal an internal component of the shell and are implanted into an animal body, so that the internal component of the shell is effectively isolated from an external organism, and the safety of the animal body is ensured while the internal component is ensured to stably run for a long time; by integrating a temperature sensor, an acceleration sensor and a gyroscope sensor, the body temperature, activity data, lying posture and other data of the implanted animal can be rapidly and accurately collected in the animal body, the behavior and physiological state of the animal can be rapidly obtained through an external receiving device, and therefore early warning of animal diseases is achieved; early intervention treatment is realized, the normal production cycle of animals is prevented from being influenced by diseases, and the production benefit is improved; in addition, a strong magnet is arranged in the shell, so that the detector can be conveniently and safely taken out from the animal body through an external magnet when needed, and the injury to the animal and the operation risk are reduced.

The invention provides an NIR-IIb / c rare earth nanoparticle fluorescent probe as well as a preparation method and application thereof. The fluorescent probe sequentially comprises a core, an active shell and an inert shell from inside to outside, wherein the core comprises Tm < 3 + > ions and Er < 3 + > ions, and the active shell comprises Er < 3 + > ions, Yb < 3 + > ions and Ce < 3 + > ions. The fluorescent probe provided by the invention has an efficient energy transfer system, not only has bright luminescence in an NIR-IIb wave band (1500-1700 nm), but also has luminous intensity increased by dozens of times in an NIR-IIc wave band (1700-1900 nm) compared with that of a traditional probe. The hydrophilic modification method of the probe is also improved, and the biocompatibility of the probe is improved by a multi-layer polymer cross coating method, so that the probe still has good luminescence property in an organism, and the penetration depth and resolution of biological tissues during imaging are improved.

The invention relates to the technical field of biological wave resonance, provides a migration analysis method and system based on biological wave resonance, and aims to solve the problems of low accuracy and poor anti-interference capability of biological wave resonance anomaly detection in the prior art. The method comprises the steps that electrocardiosignals and brain wave signals of a living body and micro-deformation data of the surface of the living body are collected, and the signal data are jointly aligned in a time-frequency domain; dynamically suppressing interference frequency bands of the electrocardiosignal and the brain wave signal which are jointly aligned respectively; fusing the suppressed electrocardiosignal, the brain wave signal and the micro-deformation data after joint alignment to generate a fusion result; determining an offset feature of the fusion result relative to a preset reference state by using convolution operation; and generating a biological wave resonance migration analysis report about whether the biological wave resonance is abnormal or not according to the continuous length and the spatial distribution range of the migration characteristics in the time domain dimension. According to the invention, the accuracy and anti-interference capability of biological wave resonance anomaly detection are improved.

The invention provides an organ chip unit for simulating the pathogenesis of rheumatoid arthritis, and belongs to the technical field of cell culture. The chip comprises a top-layer chip, a bottom-layer chip and a middle microporous membrane, the top-layer chip and the bottom-layer chip are separated by the middle microporous membrane, and the middle microporous membrane is used for enabling cells in a cell culture space of the top-layer chip and cells in a cell culture space of the bottom-layer chip not to be in direct contact, but interaction of signal molecules and substance exchange can be carried out; synovial cells and cartilage cells are injected into the bottom-layer chip or the top-layer chip to be cultured. According to the invention, multi-cell three-dimensional co-culture can be realized. Through the additional stress stimulation co-culture part, the influence of pressure or tension on the cell environment can be judged, and the actual condition that rheumatoid arthritis joints receive pressure or tension for a long time can be simulated. The synovial cells and the cartilage cells are used, so that the structure of the inflammation joint in a living body can be truly reflected, and the interaction among various cell tissues can be reflected.

The invention discloses a light and thin wearable ultrasonic device with imaging and efficient power output capabilities and a working method of the light and thin wearable ultrasonic device, and aims to solve the problems that an existing wearable ultrasonic device is large in thickness, low in imaging sensitivity and power output efficiency and serious in heating, and imaging and power output areas do not coincide. The device comprises a front-end package, an ultrasonic transducer array and a rear-end package. The front-end package is made of a flexible material and is in contact with an organism to conduct ultrasonic waves; the ultrasonic transducer array comprises an ultrasonic transducer array element with an impedance reverse matching structure, has the characteristics of being light and thin, and has imaging and efficient power output capabilities at the same time; the rear end package is used for protecting the device and providing an insulation function. According to the device, high coincidence of an imaging area and a power output area is realized by sharing the piezoelectric layer, and power output can be accurately controlled based on a real-time imaging result in combination with a closed-loop control strategy.

The invention belongs to the field of environmental analytical chemistry, and provides a method for preparing micro / nano plastic based on stable isotope labeling and application of the micro / nano plastic. Specifically, an initiator, a pH buffer solution, ultrapure water, an emulsifier and a deuterated styrene monomer are mixed and emulsified through an emulsion polymerization method, a polymerization reaction is performed after emulsification, and then the deuterated polystyrene microspheres are obtained through cleaning and drying. According to the method, high sensitivity, high accuracy and safety of deuterium labeling are utilized, and a new research thought is provided for deeply researching the migration and transformation rule of the micro / nano plastic in the environment and long-term influence of the micro / nano plastic on organisms. The method is expected to promote the wide application of a hydrogen stable isotope labeling quantitative technology in the field of environmental science, and provides a scientific basis for evaluating the influence of the micro / nano plastic on the ecological environment and human health.

By producing the proper wave interference using superimposed angularly separate waves that overlap with the proper time-phase relationship (called “Time-Correlated Standing-wave Interference”), wave energy is amplified (by “Coherent Intensity Amplification”) and teleported to precise locations. For instance, in one application, energy is teleported to one or more areas within a living body for such therapeutic applications as destroying cancer cells or plaques within arteries. A system implementing this technique creates amplified constructive interference at one or more selected disease locations, while producing destructive interference at surrounding locations. In this application example, the technique allows energy to be “teleported” to tumor cells, plaques, or other diseased cells, for instance, to destroy them, while surrounding healthy cells receive virtually no energy, obviating collateral damage from the treatment. The same method can be used to diagnose disease by detecting energy teleported to different locations.

The present invention discloses a recombinant glycosylase base editing system and its application. The recombinant glycosylase base editing system of the present invention is an APOBEC-nCas9-Ung1 or APOBEC(R33A)-nCas9-Rad51-Ung1 base editing system; the base editing system APOBEC-nCas9-Ung1 includes cytosine deaminase APOBEC, nuclease nCas9 and uracil DNA glycosylase Ung1; the base editing system APOBEC(R33A)-nCas9-Rad51-Ung1 includes cytosine deaminase APOBEC(R33A), nuclease nCas9, single-stranded DNA binding protein Rad51 and uracil DNA glycosylase Ung1. Experiments have shown that the recombinant glycosylase base editing system of the present invention can improve the editing efficiency of base C to base G in the genome sequence of an organism or a biological cell and the purity of the editing product.

The invention relates to the technical field of tissue engineering, in particular to a 3D printing platform integrated with holographic optical tweezers and a bionic tissue construction method.The printing platform comprises a holographic optical tweezers module used for forming an optical trap array in an objective lens focal region of the holographic optical tweezers module; the charging barrel is used for storing biological materials and can move between a storage position and a working position; the printing base can move between the feeding station and the optical tweezer control station; the objective table is installed on the printing base and can move in the horizontal direction and the vertical direction; the light curing device is fixed on the objective table and is used for emitting light to induce the biological material to be cured; the cell culture plate is fixed on the objective table and stacked on the photocuring device; the cell culture plate is provided with a printing chamber and a cell chamber, and the printing chamber and the cell chamber are communicated through a channel. A macroscopic ordered three-dimensional structure can be constructed, and ordering and patterning of microscale organisms in the macroscopic three-dimensional structure are also realized.

At least partial function of a human limb is restored by surgically removing at least a portion of an injured or diseased human limb from a surgical site of an individual and transplanting a selected muscle into the remaining biological body of the individual, followed by contacting the transplanted selected muscle, or an associated nerve, with an electrode, to thereby control a device, such as a prosthetic limb, linked to the electrode. Simulating proprioceptive sensory feedback from a device includes mechanically linking at least one pair of agonist and antagonist muscles, wherein a nerve innervates each muscle, and supporting each pair with a support, whereby contraction of the agonist muscle of each pair will cause extension of the paired antagonist muscle. An electrode is implanted in a muscle of each pair and electrically connected to a motor controller of the device, thereby simulating proprioceptive sensory feedback from the device.

The invention discloses a near-infrared fluorescent probe DCM-MBS for detecting ONOO <-> as well as a preparation method and application of the near-infrared fluorescent probe DCM-MBS, and belongs to the technical field of peroxynitroso ion detection. The probe DCM-MBS is a water-soluble probe, the detection method is simple, ONOO <-> response is rapid, selectivity is good, specificity is high, detection sensitivity is high, interference of other biological molecules, active substances and the background of the probe can be effectively avoided, repeatability, accuracy and reliability of a detection result are ensured, and the detection method is suitable for large-scale popularization and application. Further, the requirement of real-time monitoring of the rapidly-changed ONOO <-> level in a living body is met; the color change is obvious and easy to observe, and qualitative in-situ real-time detection of ONOO <-> can be realized by naked eyes; the fluorescent probe has very excellent biocompatibility, can realize excellent fluorescence imaging in various cells and living mouse bodies, and does not have obvious toxic or side effects; the synthesis method is simple and efficient, raw materials are low in cost and easy to obtain, large-scale industrial production is facilitated, and wide market application prospects are achieved.

The application provides application of SEBS in implanting a biological electrode base. The biological electrode based on the SEBS base can be implanted in biological tissues, and is used for continuously or discontinuously analyzing physiological parameters of the biological body. Compared with other flexible bases, the SEBS base has the characteristics of being thinner and more flexible, can reduce the interference of body movement on the electrical signal, reduce the volume range of the implanted tissue and reduce the inflammatory reaction, thereby improving the measurement accuracy and long-term stability, is expected to meet more implantation site requirements when used for implanting a sensor, and has a good application prospect.

The present disclosure provides a platform assembly for providing a comfortable resting area for one or more pets, or non-living objects, while allowing accommodation of the pets in close proximity of a friendly human being in domestic as well as work environments. The platform assembly is adapted to be detachably mounted to various types of furniture or household appliances, and ensure that the pets present in the resting area feel the presence the friendly human being at all times.

Disclosed are devices, systems, and methods for in vivo monitoring of biological fluid flow within anatomical structures, such as blood flow through heart valves (e.g., mitral, tricuspid, and / or aortic valves) or heart chambers. The disclosed devices, systems, and methods can continuously measure and evaluate blood flow back and forth at the inlet of a heart valve to determine cardiac function or dysfunction and / or to compile with other monitored data that can be used to measure or predict secondary factors.

The invention relates to the technical field of medical instruments, and provides an organ low-temperature perfusion system and a perfusion device.The organ low-temperature perfusion system comprises an organ bin and a perfusion assembly; the perfusion assembly is used for providing perfusion power and perfusing perfusion liquid into the blood vessel of the biological organ through the perfusion channel; the perfusion assembly comprises an oscillation generator, and the oscillation generator is used for applying alternating oscillation to perfusate, so that the perfusate flows in the perfusion channel and the blood vessel of the biological organ in a periodic oscillation state; a boundary layer can be broken by oscillating fluid flow, so that perfusate is more tightly attached to the surface of an organ, and the heat transfer efficiency is improved; the ice crystal structure which is being formed can be damaged, and the icing process is slowed down; a dead zone of fluid in an organ can be reduced, the uniformity of perfusate is ensured, the local temperature gradient is reduced, and tissue damage is reduced; in addition, the oscillating flow of the perfusate can more accurately simulate the physiological conditions in a real living body, and an environment closer to the interior of the living body is provided.