213results about "Eye implants" patented technology

A surgically implanted ocular optical array that can be used in both therapeutic and diagnostic applications is described. A device configured to be implanted in an eye includes: an imaging system that receives visible light incoming to the eye; optical source generating circuitry that generates an optical signal based on the light received by the imaging system; and an optical phased array (OPA) that generates and projects an image onto a retina of the eye in which the device is implanted, the image being based on the optical signal generated by the optical source generating circuitry.

This invention discloses an ocular implant and its delivery system, comprising: a flexible substrate; multiple nanowire arrays disposed on the flexible substrate; an elastic ring disposed along the circumferential edge of the flexible substrate, the elastic ring having elastic memory and capable of returning to its original shape before deformation after deformation; and two opposing openings disposed near the edge of the flexible substrate. The nanowire array of the ocular implant of this invention can be composed of multiple materials spliced ​​together, and materials with different efficacies and photosensitive wavelengths can be selected for splicing. Therefore, personalized ocular implants can be customized according to different patient conditions to achieve a better match with the patient's fundus condition. Furthermore, the folding and opening design of the ocular implant of this invention, as well as the self-expanding property of the elastic ring, enable it to be adapted to a delivery system for positioning and minimally invasive implantation.

A device and its use in a method for changing an eye color is disclosed. The device comprises a plurality of colored intracorneal ring segments of pre-defined length, width and positioning. The method comprises forming a pair of concentric intracorneal tunnels in a mid- periphery of a cornea. The pair of concentric intracorneal tunnels comprises an inner intracorneal tunnel and an outer intracorneal tunnel. The inner intracorneal tunnel is configured to accommodate a pair of colored inner ring segments wherein each of the colored inner ring segment comprises a plurality of first fenestrations. The outer intracorneal tunnel is configured to accommodate a pair of colored outer ring segments wherein, each of the colored outer ring segment comprises a plurality of second fenestrations. Furthermore, a cross-section of the pair of colored inner ring segments and the pair of colored outer ring segments is bilamellar.

This application relates to a femtosecond laser multi-degree-of-freedom personalized reshaping method and system for intracorneal implants, belonging to the field of femtosecond laser processing technology. Utilizing the cold processing characteristics of femtosecond lasers, the intracorneal implant is individually cut and ablated to obtain the desired three-dimensional corneal shape, precisely shaping the curvature, thickness, and contour of the lens to perfectly match the patient's corneal capsule or lesion area. By leveraging the nonlinear optical effect induced at the focal point of the femtosecond laser, the stromal collagen network in the weak areas corresponding to corneal expansion can be densified through laser processing, significantly improving the local elastic modulus and resistance to deformation. In areas requiring a smooth transition with the recipient cornea or adjustment of refractive power, controllable micropores or low-density areas can be induced, appropriately reducing local stiffness, thereby achieving a spatial gradient distribution of internal mechanical properties and customizing the overall mechanical behavior and morphological stability after implantation.

The present invention relates to a dental / medical device that comprises poly(dioxanone) (PDO or PDS), preferably has an absorbent synthetic film exhibiting a color from white to grey, and is applied in the medical and dental fields. The dental / medical device may have stem cells and graphene used for inducing tissue reconstruction and / or inducing tissue regeneration of bone defects and other connective tissues (such as gingiva, skin, cartilage, cornea, etc.). Further, the present invention relates to the use of the device for the related applications described above and a method for manufacturing the device.

To ensure that the implant is securely fixed until deployment and to reduce the risk of introducing undesirable particulate matter into the patient, we provide an implant with improved retention within the needle of the delivery device, which reduces the risk of retention failure based on the delivery device. [Solution] A medical implant is disclosed. The medical implant has a body having a first end having a first cross-sectional dimension, a second end having a second cross-sectional dimension, and a tapered portion extending between the first and second ends. The first cross-sectional dimension is larger than the second cross-sectional dimension. In some embodiments, the body comprises multiple layers.

An insertion device for an ocular implant for regulating intraocular pressure includes a cannula having an internal space for receiving at least a portion of an ocular implant having a stent and an implant opening for inserting the ocular implant; a handle configured to be connected to the cannula and held by a surgeon; and a holder configured to be coupled to the handle and including a receiving portion configured to receive the stent of the ocular implant. The ocular implant insertion device appropriately fixes the stent inserted into the tube of the ocular implant in a manner attached to the insertion device, thereby preventing problems such as the stent coming out of the tube, the implant being separated from the insertion device by the stent, or the stent obscuring the surgeon's field of vision during implant implantation surgery.

A method is described of improving adhesion of an ocular implant (10) to corneal tissue by forming an implant adhesive layer (14) on the ocular implant (10), the implant adhesive layer (14) having greater adhesive strength than a rest of the implant (10). This is done by making chemical and / or physical changes on an anterior surface of the implant (10) that make the implant adhesive layer (14) more adhesive than the rest of the implant (10).

The application discloses a 3D printing ocular prosthesis platform, which is prepared through the following steps: S1, designing the shape of the ocular prosthesis platform and dividing the shape into regions; S2, selecting a porous structure for the ocular prosthesis platform in each region and determining the voxel size according to the connecting point parameters of the selected porous structure; S3, voxelizing and fitting each region to form a voxelized interface; S4, filling the porous structure selected in step S2 into each corresponding region to complete the modeling of the porous structure in each region; S5, connecting the connecting points on adjacent voxelized interfaces to each other and converting the connecting lines into solid rod models to complete the modeling of the interfaces; S6, merging the models obtained in steps S4 and S5 to obtain a final model of the ocular prosthesis platform; S7, 3D printing to obtain a bioceramic blank; and S8, high-temperature sintering of the blank to obtain a 3D printed ocular prosthesis platform after porcelain forming. The application can obtain a new 3D printed ocular prosthesis platform, which provides technical support for ocular prosthesis repair.

An imaging probe comprises a camera or endoscope with an external detector array, in which the probe is sized and shaped for surgical placement in an eye to image the eye from an interior of the eye during treatment. The imaging probe and a treatment probe 500 can be coupled together with a fastener or contained within a housing. The imaging probe and the treatment probe 500 can be sized and shaped to enter the eye through an incision in the cornea and image one or more of the ciliary body band or the scleral spur. The treatment probe 500 may comprise a treatment optical fiber or a surgical placement device to deliver an implant. A processor coupled to the detector can be configured with instructions to identify a location of one or more of the ciliary body band, the scleral spur, Schwalbe's line, or Schlemm's canal from the image.

This invention provides a method for encapsulating cells in microtissue. [Solution] A method for encapsulating cell microtissues includes coating a tissue scaffold stamp with an extracellular matrix compound. The method includes placing the tissue scaffold stamp on a thermoresponsive substrate and seeding a cell culture onto the tissue scaffold stamp. The cell culture forms cell patches that bind to the extracellular matrix compound. A monolayer boundary on the tissue scaffold stamp maintains expression for intercellular junctions, where the monolayer intercellular junctions are configured to express tension. The method includes removing the thermoresponsive substrate. The method includes folding the microtissue structure by suspending the microtissue in a solvent. The folded microtissue structure is recovered from the solvent and administered to a living organism.

The present disclosure relates to a support element (10) for an artificial cornea, the support element being disc-shaped and concentric with a central axis (P) and comprising: a central region (101) and a perimetral (102) region adjacent to a perimeter edge of the support element, the central region comprising a convex face (1011), a concave face (1012) opposed to each other and one central through hole (103) concentric with the central axis; wherein the perimetral region is flared, the surface of the support element is coated with silver, and at least the concave face of the support element comprises a peptide or a pharmaceutical salt thereof attached therein. The present disclosure also relates to an artificial cornea comprising the support element described.

The present disclosure discloses a bioengineered formulation comprising: (a) a modified collagen peptide having a molecular weight in the range of 20-80 kDa, and with a degree of substitution in the range of 20-75%; and (b) a modified hyaluronic acid having a molecular weight in the range of 10-100 kDa, and with a degree of substitution in the range of 20-75%. The present disclosure also discloses the bioengineered formulation comprising stem cells, or exosomes, or combinations thereof. Further, the process for preparing the bioengineered formulation is also disclosed therein. Moreover, the formulation comprising: a) exosomes selected from the group consisting of corneal stromal stem cell derived-exosomes, primed mesenchymal stem cell derived-exosomes, and naive mesenchymal stem cell derived-exosomes; and (b) a clinically approved eye drop formulation is also provided.

An apparatus including a reservoir and a therapeutic substance located in the reservoir, wherein the apparatus is an implantable therapeutic substance delivery apparatus, and the apparatus is configured to deliver the therapeutic substance to a recipient thereof by diffusion controlled release. In an exemplary embodiment, the apparatus is also a cochlear implant.

Provided is an intraocular implant delivery device, comprising a housing (1), a main control pull rod assembly (5), a slider assembly (6), a striking assembly (7), a retracting needle turntable (8), and a push needle assembly (3). The main control pull rod assembly (5), the slider assembly (6), the striking assembly (7), and the retracting needle turntable (8) are all arranged in the housing (1). A through hole (13) is provided at a distal end of the housing (1), and a push needle (31) of the push needle assembly (3) passes through the through hole (13) and extends to an outer side of the housing (1). The main control pull rod assembly (5), the slider assembly (6), and the striking assembly (7) are each provided with an energy source (73) capable of selectively releasing energy. The main control pull rod assembly (5) is actuated by an operator through a button (4) arranged on the housing (1), so that the energy source (73) drives the main control pull rod assembly (5) to move axially.

Systems and methods for preparation of an implant and ab interno insertion of the implant into an eye of a patient including a tissue cartridge configured to receive and hold a patch of a material; a cutting device; and a delivery device. Related devices, systems, and methods are provided.

The present invention discloses compositions and methods for repair and reconstruction of defects and injuries to soft tissues. Some aspects of the disclosure provide methods for corneal reconstruction by applying an engineered bioadhesive, glycidyl methacrylate-substituted gelatin and a visible light activated photoinitiator in presence of visible light to the corneal defect.

The present invention provides a delivery device (10) for percutaneously implanting a medical implant (1) into a patient's tissue. The delivery device comprises a delivery sheath (12, 13, 53, 61, 62, 65, 66) configured to at least partially surround the medical implant and hold the medical implant for percutaneous delivery into the patient's tissue. The delivery device also comprises a power supply system (37) configured to supply power to the medical implant within the delivery sheath.

The invention relates to a supporting membrane (1), an implant (2) having a supporting membrane (1), and a method for producing a supporting membrane (1). The supporting membrane (1) is suitable for supporting the treatment of endothelial disorders of a cornea (7) of a human or an animal and has a substrate (6) which is suitable for fastening to a rear wall (8) of the cornea (7). The described technical solution is characterised in that the substrate (6) comprises three layers (3, 4, 5) arranged one above the other, of which a middle layer (5) is formed in the form of a film and has an edge (9) which is suitable for anchoring in the cornea (7), and in that outer layers (3, 4) arranged on either side of the middle layer (5) at least in regions on this layer each have a porous, liquid-permeable fibre structure.

An intraocular system that includes a headset that optically transmits data and power to an implant. The headset includes a camera to capture image data that includes a visual representation of an environment of the headset and an optical transmitter to transmit the image data as an optical signal into a cornea of an eye of a user when the user is wearing the headset. The implant includes an optical receiver to receive the optical signal through the cornea and an image formation device orientated to present the image data from the optical signal onto a retina of the eye when the implant is inside the eye.

A method and a system of determining shape and appearance information of an ocular prosthesis for a patient, a computer program product and a conformer The invention relates to a method and a system of determining shape and appearance information of an ocular prosthesis (7) for a patient, comprising the steps of: - generating shape information for the ocular prosthesis (7), - determining the shape of the ocular prosthesis (7) depending on said shape information, - generating appearance information for the ocular prosthesis by capturing an image of a patient's eye, - fusing the shape and the appearance information, wherein the determination of the shape of the ocular prosthesis comprises - determining the shape based on a shape model being determined based on the shapes of existing prostheses or - determining the shape by generating shape information of an existing patient- specific prosthesis and transforming it into a uniform shape representation, and / or the generation of appearance information comprises performing at least one of - an inhomogeneous illumination correction and - a color characterization being performed using the same or similar viewing conditions as a color characterization of a device used for the manufacturing of the ocular prosthesis based on the appearance information. as well as a computer program product and a conformer (19). -

An artificial retinal prosthesis is disclosed for electrically stimulating a retina of an eye by spatiotemporal electrical stimulation to provide color visual perception. The prosthesis comprises a plurality of pixel group units, each including a main pixel unit and at least one auxiliary pixel unit. The main and auxiliary pixel units are driven according to different sequences of cycles, each cycle comprising a dark period followed by a lighted period, such that the pixel units intermittently output lighted pulses. During the lighted periods, the main pixel unit is nominally turned on for at least one lighted duration except for an off duration while the auxiliary pixel units are continuously turned on for the entire lighted period. During the dark periods, both the main pixel unit and the auxiliary pixel units are continuously turned off for the entire dark period.

This patent relates to a three-piece foldable artificial iris with haptics, its manufacturing method, and an intraocular implantation system. The artificial iris includes an iris body with a foldable iris skeleton embedded within it. The cross-sectional area of ​​the iris skeleton at the fold is smaller than that at other locations. An arc-shaped suture is provided on the iris body to assist in fixing the artificial lens. The implantation system includes an injector, a guide needle, and an iris support. The guide needle facilitates the extraction of the anchor expansion portion. The implantation system assists in the implantation of the artificial iris, reducing tissue damage, minimizing intraoperative and postoperative patient discomfort, reducing surgical complexity, and increasing safety.

An intraocular implant that includes several lasers to produce several laser beams, where each laser beam has a different color. The implant also includes a diffraction grating to diffract the laser beams into a combined laser beam onto a retina of an eye when the implant is inside the eye, and a micro-electro-mechanical system (MEMS) scanner to move the combined laser beam over an area of the retina when the implant is inside the eye.

A system for selecting a preferred intraocular lens for implantation into an eye includes a controller having a processor and a tangible, non-transitory memory. The controller is configured to obtain diagnostic data of the eye, and obtain historical data composed of historical sets of patient data. The controller is configured to analyze individual risk factors based on the diagnostic data and obtain a weighted combination of the individual risk factors. A respective satisfaction metric for the plurality of intraocular lenses is generated based on the historical data. A preferred intraocular lens may be selected based in part on the respective satisfaction metric and the weighted combination. A visual simulation for each of the plurality of intraocular lenses may be performed, based in part on the diagnostic data. The visual simulation may incorporate an impact of the tear film data.

A medical device for office-based / operating room minimally invasive bleb-forming glaucoma surgery, the medical device including a proximal segment for grasping by a user, the distal segment including a puncturing member coupled to and extending from the distal segment, the puncturing member configured to receive and deliver an ocular implant into an ocular tissue layer to obtain a channel, the proximal and distal segments configured to couple to one another at a pivot point between an unlocked configuration and a locked configuration, and in the unlocked configuration, the proximal and distal segments are rotatable relative to one another about an axis of rotation at the pivot point.

The invention relates to an extraocular implant (1) used for preventing the worsening of pathological myopia, said implant comprising a frame (10) in the form of an arm having anchoring means at one end and a concavity (120) at the other. The implant (1) is characterized in that it also comprises a pocket (13) in which a suitable compound is placed to inflate said pocket (13). The pocket (13) is positioned at the second end of the arm to occupy said concavity (120). The implant (1) also comprises a hooking device (130) arranged on said pocket (13) to be positioned on the posterior part of the eye. Figure to be published with the abbreviation: Figure 4

A cell transplant carrier including a carrier plate and a carrier housing. The carrier plate includes a body and one or more chambers defined in the body. Each of the one or more chambers is configured to receive a cell transplant and is shaped to cause the cell transplant to be at least partially exposed in order to permit removal of the cell trasnplant therefrom. The carrier housing includes a carrier plate opening leading to an inner compartment configured to removably receive the carrier plate.