454results about "Eye implants" patented technology

Systems and methods for delivering multiple ocular implants to reduce intraocular pressure are disclosed. The ocular implants can be implanted at multiple sites within a single human eye without requiring removal of the delivery apparatus from the eye. A system for delivering multiple ocular implants can include at least two implants preloaded within a delivery device and configured to be implanted within the eye, a metering device configured to transfer energy to the implants for delivery at selected locations within the eye, wherein the metering device is configured to meter a variable amount of energy for each implant delivery event in the eye. The system can further include an injector mechanism configured to serially engage and drive each of the implants.

Systems and methods for delivering multiple ocular implants to reduce intraocular pressure are disclosed. The ocular implants can be implanted at multiple sites within a single human eye without requiring removal of the delivery apparatus from the eye. A system for delivering multiple ocular implants can include at least two implants preloaded within a delivery device and configured to be implanted within the eye, a metering device configured to transfer energy to the implants for delivery at selected locations within the eye, wherein the metering device is configured to meter a variable amount of energy for each implant delivery event in the eye. The system can further include an injector mechanism configured to serially engage and drive each of the implants.

Systems and methods for delivering an implant to treat an ocular disorder is disclosed. The ocular implant can include a treatment fluid that is released over the course of several days or months to treat an ocular disorder. A system for implanting and retrieving spent implants can include an implant, an external housing, and an implant assembly. The external housing can provide access to a sliding trigger. The sliding trigger can convert a portion of the implant assembly from a first configuration to a second configuration and a second configuration to a third configuration to release or retrieve an implant. In some embodiments, the implant assembly can include a collet formed from sheet metal and bent to act as a spring. The collet can have protrusions to match the profile of an implant to secure the implant during delivery. Actuation of the trigger can relieve the spring's pressure.

Shape-stabilized collagen scaffolds and methods of obtaining such scaffolds are disclosed. Stroma can be harvested, for example, from human or porcine corneal stroma and shaped during excision or in a separate step after excision. Following shaping (and preferably decellularization), the excised stroma portion is subject to pressure, force or vacuum to reduce fluid content and then irradiated or otherwise treated to induce crosslinking of collagen chains or fibrils. In one embodiment, the scaffold can be compacted by removing some or all of the water from the scaffold, and rehydrating the scaffold in a controlled manner (e.g., in a mold or other confining space) such that the scaffold takes a desired compacted shape; and then crosslinking at least a portion of the scaffold to mechanically strengthen it and inhibit subsequent swelling. Various sources of energy can be employed to induce crosslinking of collagen including, for example, ultraviolet (UV) radiation. The scaffolds can also be selectively densified or patterned. The invention is particularly useful in forming stable lenticules of enhanced stiffness and sufficient optical clarity for intracorneal implantation in additive ocular surgery.

Disclosed herein are systems, devices, kits, and associated methods for treating conditions of the eye by reducing intraocular pressure. The system may include an ocular implant and a delivery device. The ocular implant may be implantable within Schlemm's canal to restore or maintain at least partial patency of the canal without substantially interfering with transmural or transluminal fluid flow across the canal. The delivery device may include a cannula comprising a straight proximal portion and a curved distal portion, where the curved distal portion comprises a first curve in a first direction. The delivery device may also include a positioning tool positioned at least partially within the cannula and configured to advance the ocular implant through the cannula, where the positioning tool comprises a curved distal portion biased to form a second curve in a second, different direction.

The invention discloses a preparation method of a bionic cornea stroma lens for refractive correction, which comprises the following steps: solution preparation: dissolving type I collagen in an acetic acid solution, adding a film aid, fully stirring, and centrifugally defoaming to obtain a type I collagen composite solution; the I-type collagen composite solution is poured into an assembling groove, the curvature radius of titanium metal is set to be 6.8-8.0 mm, the titanium metal serves as a working electrode material, platinum metal serves as a counter electrode material, current parameters are set according to the needed thickness of the lens blank, the density is 3.50-6.50 mA / cm < 2 >, and the thickness of the lens blank is set to be 3.50-6.50 mA / cm < 2 >; a high-transparency cornea embryo material which is uniform in curvature in all directions and similar to human cornea fiber structure arrangement is formed after electrochemical assembly and cross-linking curing, accurate cutting machining is carried out through excimer laser, a concave / convex matrix lens with the needed correction degree is obtained, the correction precision is high after cornea interlayer implantation, and the correction precision is high. And meanwhile, the compound has excellent performance in the aspects of in-vivo stability and biological safety.

Decellularized and shaped corneal tissue lenticules from allograft and / or xenograft sources and methods of obtaining such lenticules are disclosed. The lenticules are particularly useful as intrastromal lenticular implants in keratoplasty procedures, in which a hinged flap is formed in a patient's cornea and folded back along its hinge to expose the stromal bed of the cornea. The shaped lenticule is then applied to the stromal bed and the flap returned to its original position yielding a new curvature for the cornea and resulting in a desired refractive correction. Fine-tuning of the new refractive power can be achieved by laser ablation either at the same time as implantation or at later time in the event of regression or tonus changes. Methods of decellularizing cornea tissue are disclosed to reduce potential immunogenic reactions on the part of the patient to the implanted lenticule. The lenticules can be further treated to remove immunogenic epitopes. In addition, the posterior and / or anterior surfaces of the lenticule can be treated to assist in intrastromal seating of the lenticule and / or to reduce the likelihood of dislodgement. The methods of forming lenticules can further include preserving at least a portion of the Bowman's membrane. The smoothness of the Bowman's membrane surface also makes it less likely that reopening the flap will dislodge the lenticule.

A medical device for office-based / operating room bleb forming minimally invasive glaucoma surgeries. The medical device includes a proximal segment for grasping by a user, a distal segment that includes a piercing member coupled to and extending from the distal segment, wherein the piercing member is configured to contain and deliver an ocular implant into an eye tissue layer to obtain a channel, wherein the proximal segment and the distal segment being configured to couple to each other at a pivot point between an unlocked configuration and a locked configuration, and wherein in the unlocked configuration, the proximal segment and the distal segment are rotatable relative to each other about a rotation axis at the pivot point.

The invention discloses an aspheric keratoprosthesis lens column, a keratoprosthesis and an application method of the aspheric keratoprosthesis lens column, the whole lens column is cylindrical, the front surface of the lens column is a convex surface, the rear surface of the lens column is a concave surface, the rear surface of the lens column is a surface close to the retina, the front surface of the lens column is a surface far away from the retina, and the front surface and the rear surface of the lens column are both curved surfaces. And the spherical surfaces are rotationally symmetrical aspheric surfaces. The artificial cornea comprises a lens column and a support, and the lens column is installed on the support. The fixed position of the lens column is that the distance between the vertex of the rear surface of the lens column and the retina is 10-120mm, the focal plane is perpendicular to the optical axis, and the inclination angle of the focal plane is 0 degree. According to the lens column, spherical aberration and coma can be effectively corrected, and the imaging quality is improved; light scattering is reduced, the visual contrast at night and in a low-light environment is improved, and the visual experience of a patient is improved; the deviation tolerance of the implantation position is higher, and the operation difficulty and the risk of postoperative complications are reduced.

The invention provides an ultralow-swelling artificial cornea imitating natural cornea fiber arrangement and a preparation method, and belongs to the technical field of biomedical materials.The preparation method comprises the steps that I-type collagen is dissolved in a PBS buffer solution, a photofunctionalization modified active reagent is added for chemical modification, stirring is conducted in a dark place, freeze drying is conducted, and photofunctionalization collagen is obtained; dissolving the photo-functionalized collagen, and then preparing a collagen fiber membrane through electrostatic spinning; and performing phase change DLP 3D biological printing on the biological ink and the collagenous fiber membrane to obtain the keratoprosthesis with the collagenous fiber sandwich structure. Multi-layer arrangement is achieved through DLP 3D biological printing, the fiber trend of the natural cornea is simulated, and the mechanical anisotropy is remarkably improved; through a composite phase change DLP 3D printing mode of GelMA / HA-DN and photo-crosslinking collagenous fibers, the composite phase change DLP 3D printing material has good manufacturability, maintains high light transmittance and maintains high mechanical strength.

Electrospun nanofiber membranes are provided. The membranes are electrospun from a suitable biocompatible and biodegradable biopolymer, e.g. gelatin, collagen, etc., to generate a membrane, which is then cross-linked. The membrane may be seeded with cells. The compositions find use tissue regeneration, particularly in repair, regeneration, and / or reconstruction of lamellar or partial defects of wounded corneal tissue.

The present invention discloses a one-time implant artificial cornea, belonging to the technical field of in-vivo prosthesis implantation. It solves at least the problems existing in the prior art, such as the need for donor corneas, multiple surgeries, large trauma, and inapplicability to patients with severe corneal blindness. The one-time implant artificial cornea includes a stent and a lens column. The lens column includes a lens column body and a rear disc coaxially arranged at the rear end face of the lens column body. The lens column is detachably connected to the stent coaxially. In the use state, the rear end of the lens column body behind the rear disc protrudes into the eye, the rear disc fits the posterior surface of the cornea, and the stent fits the anterior surface of the cornea. The stent is fixed on the corneal surface by using a suture method. At the same time, the stent and the rear disc clamp the cornea from the front and the back. The present invention also provides a method for using the one-time implant artificial cornea. It has the advantages of one-time implantation, no need for donor corneas, small trauma, and applicability to patients with severe corneal blindness, and has broad application prospects.

Systems and methods for preparation of an implant and ab interno insertion of the implant into an eye of a patient including a tissue cartridge configured to receive and hold a patch of a material; a cutting device; and a delivery device. Related devices, systems, and methods are provided.

A method of lamellar corneal graft implantation is disclosed herein. The method includes the steps of: (i) forming one or more intrastromal incisions in a cornea of an eye of a patient; (ii) removing a cut portion of the cornea defined by the one or more intrastromal incisions from the eye of the patient; (iii) applying laser energy to a lamellar corneal graft using an excimer laser so as to modify the refractive power of the lamellar corneal graft, the lamellar corneal graft being in the form of a autologous corneal graft or a homologous corneal graft; and (iv) implanting the lamellar corneal graft into the eye of the patient in a location previously occupied by the cut portion of the cornea so as to correct the refractive power of the eye of the patient.

Provided is an intraocular implant delivery device, comprising a housing, a main control pull rod assembly, a slider assembly a striking assembly, a retracting needle turntable, and a push needle assembly. The main control pull rod assembly, the slider assembly, the striking assembly, and the retracting needle turntable are all arranged in the housing. A through hole is provided at a distal end of the housing, and a push needle of the push needle assembly passes through the through hole and extends to an outer side of the housing. The main control pull rod assembly, the slider assembly, and the striking assembly are each provided with an energy source capable of selectively releasing energy. The main control pull rod assembly is actuated by an operator through a button arranged on the housing, so that the energy source drives the main control pull rod assembly to move axially.

A system for treating an eye comprising a tissue stored within a lumen of an elongated cannula, the tissue comprises scleral, amniotic membrane, or acellular biomatrix tissue and having an elongated form factor. Related devices, systems, and methods are provided.

A surgically implanted ocular optical array that can be used in both therapeutic and diagnostic applications is described. A device configured to be implanted in an eye includes: an imaging system that receives visible light incoming to the eye; optical source generating circuitry that generates an optical signal based on the light received by the imaging system; and an optical phased array (OPA) that generates and projects an image onto a retina of the eye in which the device is implanted, the image being based on the optical signal generated by the optical source generating circuitry.

A device configured to be implanted in an eye includes: an imaging system that receives visible light incoming to the eye; a projection system that generates and projects an image onto a retina of the eye in which the device is implanted, the image being based on the received visible light; and one or more haptics that include one or more electronic components, wherein the one or more haptics are movable relative to a central portion of the device such that the device can be arranged in a collapsed configuration and an expanded configuration.

The invention relates to a method for producing control data for correcting the refraction of an eye (2) by corneal modification, comprising the steps of receiving data about a refraction correction need for the eye (2), determining, on the basis of the refraction correction need, an additive refraction alteration value by an implant (26) to be inserted into the cornea (17), determining a subtractive refraction alteration value by a lenticule (21) to be removed from the cornea (17), the additive refraction alteration value and the subtractive refraction alteration value together yielding the refraction correction need, calculating a lenticule (21) to be isolated in the cornea (17), the calculation being implemented in such a way on the basis of the subtractive refraction alteration value that the lenticule (21) is embodied to bring about the subtractive refraction alteration value as a result of being removed from the cornea (17).

This invention discloses an ocular implant and its delivery system, comprising: a flexible substrate; multiple nanowire arrays disposed on the flexible substrate; an elastic ring disposed along the circumferential edge of the flexible substrate, the elastic ring having elastic memory and capable of returning to its original shape before deformation after deformation; and two opposing openings disposed near the edge of the flexible substrate. The nanowire array of the ocular implant of this invention can be composed of multiple materials spliced ​​together, and materials with different efficacies and photosensitive wavelengths can be selected for splicing. Therefore, personalized ocular implants can be customized according to different patient conditions to achieve a better match with the patient's fundus condition. Furthermore, the folding and opening design of the ocular implant of this invention, as well as the self-expanding property of the elastic ring, enable it to be adapted to a delivery system for positioning and minimally invasive implantation.

A device and its use in a method for changing an eye color is disclosed. The device comprises a plurality of colored intracorneal ring segments of pre-defined length, width and positioning. The method comprises forming a pair of concentric intracorneal tunnels in a mid- periphery of a cornea. The pair of concentric intracorneal tunnels comprises an inner intracorneal tunnel and an outer intracorneal tunnel. The inner intracorneal tunnel is configured to accommodate a pair of colored inner ring segments wherein each of the colored inner ring segment comprises a plurality of first fenestrations. The outer intracorneal tunnel is configured to accommodate a pair of colored outer ring segments wherein, each of the colored outer ring segment comprises a plurality of second fenestrations. Furthermore, a cross-section of the pair of colored inner ring segments and the pair of colored outer ring segments is bilamellar.

This application relates to a femtosecond laser multi-degree-of-freedom personalized reshaping method and system for intracorneal implants, belonging to the field of femtosecond laser processing technology. Utilizing the cold processing characteristics of femtosecond lasers, the intracorneal implant is individually cut and ablated to obtain the desired three-dimensional corneal shape, precisely shaping the curvature, thickness, and contour of the lens to perfectly match the patient's corneal capsule or lesion area. By leveraging the nonlinear optical effect induced at the focal point of the femtosecond laser, the stromal collagen network in the weak areas corresponding to corneal expansion can be densified through laser processing, significantly improving the local elastic modulus and resistance to deformation. In areas requiring a smooth transition with the recipient cornea or adjustment of refractive power, controllable micropores or low-density areas can be induced, appropriately reducing local stiffness, thereby achieving a spatial gradient distribution of internal mechanical properties and customizing the overall mechanical behavior and morphological stability after implantation.

A device for applying a bubble of a substance to a tissue surface, the device comprising a cannula, a distal tip at the distal end portion of the cannula, the distal tip having a bubble support surface and an exit port extending through the bubble support surface, an expansion fluid passageway extending through the cannula to the exit port, a source of an expansion fluid and an actuator therefor. In some arrangements, the distal tip can be configured to support a layer of the substance thereon over the distal port and the device can be configured such that the advancement of the expansion fluid from the fluid source through the exit port causes at least one bubble of the substance to form on the distal tip, wherein the at least a portion of the bubble can be transferred to the tissue surface to treat a defect on the tissue surface.

The present invention relates to a dental / medical device that comprises poly(dioxanone) (PDO or PDS), preferably has an absorbent synthetic film exhibiting a color from white to grey, and is applied in the medical and dental fields. The dental / medical device may have stem cells and graphene used for inducing tissue reconstruction and / or inducing tissue regeneration of bone defects and other connective tissues (such as gingiva, skin, cartilage, cornea, etc.). Further, the present invention relates to the use of the device for the related applications described above and a method for manufacturing the device.

To ensure that the implant is securely fixed until deployment and to reduce the risk of introducing undesirable particulate matter into the patient, we provide an implant with improved retention within the needle of the delivery device, which reduces the risk of retention failure based on the delivery device. [Solution] A medical implant is disclosed. The medical implant has a body having a first end having a first cross-sectional dimension, a second end having a second cross-sectional dimension, and a tapered portion extending between the first and second ends. The first cross-sectional dimension is larger than the second cross-sectional dimension. In some embodiments, the body comprises multiple layers.

The invention relates to a transport holder (1) for a receiving device for a transplant or implant, in particular for a DMEK lamella. During transport and / or storage, the transport holder (1) is arranged together with the receiving device in a container filled with a medium. The transport holder (1) has resilient means (4) at a first lateral end and, at a second lateral end opposite the first lateral end, a device (3) for gripping the transport holder. The transport holder is designed such that the resilient means (4) press the means (3) for grasping the transport holder during transport and / or storage against a lid of the container, and the means (3) for grasping the transport holder are pushed out of an opening in the container, owing to the resilient means (3), after the lid has been opened, such that the means (3) for grasping the transport holder can move outside the container and can be grasped. The invention also relates to a transport system comprising such a transport holder.

An insertion device for an ocular implant for regulating intraocular pressure includes a cannula having an internal space for receiving at least a portion of an ocular implant having a stent and an implant opening for inserting the ocular implant; a handle configured to be connected to the cannula and held by a surgeon; and a holder configured to be coupled to the handle and including a receiving portion configured to receive the stent of the ocular implant. The ocular implant insertion device appropriately fixes the stent inserted into the tube of the ocular implant in a manner attached to the insertion device, thereby preventing problems such as the stent coming out of the tube, the implant being separated from the insertion device by the stent, or the stent obscuring the surgeon's field of vision during implant implantation surgery.

Disclosed are devices and methods for the improvement of ectatic keratopathy using corneal augmentations derived from corneal tissue. The shape of the augmentation is determined using data obtained from computerized corneal topography and tomography-based mapping of the patient's cornea. Factors considered include maximum corneal curvature measurements and specific iso-deviation contours. In one embodiment, the augmentation is a corneal inlay intended for insertion into an intrastromal pocket. In a further embodiment, the augmentation is a corneal onlay intended to be positioned over an area of ​​the cornea from which an epithelial layer has been removed. The corneal onlay is held in place until the epithelial layer regrows over the augmentation. In a further embodiment, the inlay or onlay augmentation is followed by further reshaping after augmentation of the corneal augmentation. In one embodiment, this further reshaping is photorefractive keratectomy (PRK) surgery.

A system and method for preparing and inserting an implant into a patient's eye from within the eye, the system including a tissue cartridge configured to receive and hold a patch of substance, a cutting device, and a delivery device. Related devices, systems, and methods are provided.