A
radiosurgery system is described that is configured to deliver a therapeutic
dose of
radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically
macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the
dose of
radiation. In some embodiments, the target tissues are placed in a
global coordinate system based on
ocular imaging. In some embodiments, the target tissues inside the
global coordinate system lead to direction of an automated
positioning system that is directed based on the target tissues within the coordinate
system. In some embodiments, a
treatment plan is utilized in which
beam energy and direction and duration of time for treatment is determined for a specific
disease to be treated and / or structures to be avoided. In some embodiments, a
fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the
system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which
radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.