7187 results about "Optical imaging" patented technology

The invention describes several embodiments of an adapter which can make use of the devices in any commercially available digital cameras to accomplish different functions, such as a fundus camera, as a microscope or as an en-face optical coherence tomography (OCT) to produce constant depth OCT images or as a Fourier domain (channelled spectrum) optical coherence tomography to produce a reflectivity profile in the depth of an object or cross section OCT images, or depth resolved volumes. The invention admits addition of confocal detection and provides simultaneous measurements or imaging in at least two channels, confocal and OCT, where the confocal channel provides an en-face image simultaneous with the acquisition of OCT cross sections, to guide the acquisition as well as to be used subsequently in the visualisation of OCT images. Different technical solutions are provided for the assembly of one or two digital cameras which together with such adapters lead to modular and portable high resolution imaging systems which can accomplish various functions with a minimum of extra components while adapting the elements in the digital camera. The cost of such adapters is comparable with that of commercial digital cameras, i.e. the total cost of such assemblies of commercially digital cameras and dedicated adapters to accomplish high resolution imaging are at a fraction of the cost of dedicated stand alone instruments. Embodiments and methods are presented to employ colour cameras and their associated optical sources to deliver simultaneous signals using their colour sensor parts to provide spectroscopic information, phase shifting inferometry in one step, depth range extension, polarisation, angular measurements and spectroscopic Fourier domain (channelled spectrum) optical coherence tomography in as many spectral bands simultaneously as the number of colour parts of the photodetector sensor in the digital camera. In conjunction with simultaneous acquistion of a confocal image, at least 4 channels can simultaneously be provided using the three color parts of conventional color cameras to deliver three OCT images in addition to the confocal image.

The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image, signals during scanning a region of interest.

An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patient's body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a bend of the optical fiber, and this an interference contrast varies depending on the condition of the insertion. The OCT of the present invention is provided with polarization compensation means such as a Faraday rotator on the side of the light emission of the optical probe, so that the OCT can obtain the stabilized interference output regardless of the state of the bend.

An optical imaging system comprising: a taking lens system that collects light from a scene being imaged with the optical imaging system; a 3D camera comprising at least one photosurface that receives light from the taking lens system simultaneously from all points in the scene and provides data for generating a depth map of the scene responsive to the light; and an imaging camera comprising at least one photosurface that receives light from the taking lens system and provides a picture of the scene responsive to the light.

A compound-eye imaging device comprises an imaging device body having 9 optical lenses and a solid-state imaging element for imaging unit images formed by the optical lenses. Assuming that the combination of each of the optical lenses with a corresponding divided area of the solid-state imaging element to image each of the corresponding unit images is an imaging unit, thereby forming multiple imaging units, the respective imaging units have randomly different optical imaging conditions. For example, the focal lengths of the 9 optical lenses are set to have random values in which the optical lenses are arranged to have random distances between adjacent ones thereof in a direction parallel to the major surface of the solid-state imaging element. This compound-eye imaging device substantially prevents unit images formed by respective imaging units from being the same, making it possible to easily increase the definition of a reconstructed image.

An improved optical imaging system includes a vertically stacked pixel array and a lenslet array for capturing images while minimizing the focal length. The vertically stacked pixel array is configured to operate as an image sensor. The lenslet array is configure to focus the image on the image sensor. Each lens of the lenslet array focuses an image on a sub-array of the image sensor. Each sub-array is shifted from one another so that additional data obtained for each equivalent pixel in each sub-array. An image is obtained by combining the data of each sub-array.

An optical imaging system for pickup, sequentially arranged from an object side to an image side, comprising: the first lens element with positive refractive power having a convex object-side surface, the second lens element with refractive power, the third lens element with refractive power, the fourth lens element with refractive power, the fifth lens element with refractive power; the sixth lens element made of plastic, the sixth lens with refractive power having a concave image-side surface with both being aspheric, and the image-side surface having at least one inflection point. By such arrangements, the optical imaging system for pickup satisfies conditions related to shorten the total length and to reduce the sensitivity for using in compact cameras and mobile phones with camera functionalities.

An optical imaging device of the present invention comprises: a light source device; a light guide and illumination lens, provided in an insertion section that can be inserted into a body cavity, for constituting an illumination light path for guiding an illumination light from the light source device to a subject; an objective lens for receiving return lights from the subject; an image capturing section for acquiring a visible light band image from the return light; an excitation light cut filter and image capturing section for acquiring a fluorescent image from the return lights; and an illumination light filter, provided on the illumination light path, for decreasing light in a band overlapping with the band of light of which image is captured by the image capturing section from the illumination light incident on.

A fiber optic probe and a balloon catheter used in conjunction with optical imaging systems, in particular with systems which deliver and collect a single spatial mode beam, such as a single photon, a multiphoton, confocal imaging and ranging systems, such as fluorescence imaging systems.

Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and / or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and / or an orientation of the first arrangement with respect to the luminal or hollow sample.

Described are systems for patterning a substrate by imprint lithography. Imprint lithography systems include an imprint head configured to hold a template in a spaced relation to a substrate. The imprint lithography system is configured to dispense an activating light curable liquid onto a substrate or template. The system includes a light source that applies activating light to cure the activating light curable liquid. Multiple optical imaging devices are used to align the template with the substrate.

A method for detecting and localizing a target tissue within the body in the presence of ambient light in which an optical contrast agent is administered and allowed to become functionally localized within a contrast-labeled target tissue to be diagnosed. A light source is optically coupled to a tissue region potentially containing the contrast-labeled target tissue. A gated light detector is optically coupled to the tissue region and arranged to detect light substantially enriched in target signal as compared to ambient light, where the target signal is light that has passed into the contrast-labeled tissue region and been modified by the contrast agent. A computer receives signals from the detector, and passes these signals to memory for accumulation and storage, and to then to image processing engine for determination of the localization and distribution of the contrast agent. The computer also provides an output signal based upon the localization and distribution of the contrast agent, allowing trace amounts of the target tissue to be detected, located, or imaged. A system for carrying out the method is also described.

The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.

The present invention provides various methods / systems of optical imaging of subsurface anatomical structures and biomolecules utilizing red and infrared radiant energy. Also provided are various applications of such methods / systems in medical diagnosis and treatment.

An optical device for imaging is disclosed having at least one micro lens field with at least two micro lenses and one image sensor with at least two image detector matrices. The at least two image detector matrices each include a plurality of image detectors and there is an allocation between the image detector matrices and the micro lenses, so that each micro lens together with an image detector matrix forms an optical channel. The center points of the image detector matrices are shifted laterally by different distances, with respect to centroids, projected onto the image detector matrices, of the micro lens apertures of the associated optical channels, so that the optical channels have different partially overlapping detection areas and so that an overlapping area of the detection areas of two channels is imaged onto the image detector matrices offset with respect to an image detector raster of the image detector matrices. Further, an image processing device and a method for optical imaging are described.

A method is provided for fabricating a unit including a semiconductor element such as a sensor unit, e.g., for optical imaging. A semiconductor element has plurality of conductive features exposed at the front surface and semiconductive or conductive material exposed at least one of the front and rear surfaces. At least some of the conductive features are insulated from the exposed semiconductive or conductive material. By electrodeposition, an insulative layer is formed to overlie the at least one of exposed semiconductive material or conductive material. Subsequently, a plurality of conductive contacts and a plurality of conductive traces are formed overlying the electrodeposited insulative layer, the conductive traces connecting the conductive features to the conductive contacts. The unit can be incorporated in a camera module having an optical element in registration with an imaging area of the semiconductor element.

A spinal nerve tissue ablation apparatus includes a stylet needle with a distal end having a rounded blunt tip sufficiently sharp to penetrate tissue but sufficiently blunt to avoid impinging on bony surfaces of spinal vertebra. The apparatus includes an energy delivery device having at least a first electrode and a second electrode. Each electrode has a tissue piercing distal end and is positionable in the stylet as the stylet is advanced through tissue. The first and second electrodes are deployable with curvature from the stylet. The stylet includes rotational means for orienting the first and second electrodes and directing the extension according to the curvature of the electrodes. The stylet further includes an optical imaging module to provide continual progressive feedback of ablation surface development. The apparatus further includes an ultra-wide band radio frequency scanning device capable of accurately determining the location of the electrodes within the spinal structure.

An imaging system, methodology, and various applications are provided to facilitate optical imaging performance. The system contains a sensor having one or more receptors and an image transfer medium to scale the sensor and receptors in accordance with resolvable characteristics of the medium, and as defined with certain ratios. A computer, memory, and / or display associated with the sensor provides storage and / or display of information relating to output from the receptors to produce and / or process an image, wherein a plurality of illumination sources can also be utilized in conjunction with the image transfer medium. The image transfer medium can be configured as a k-space filter that correlates projected receptor size to a diffraction-limited spot associated with the image transfer medium, wherein the projected receptor size can be unit-mapped within a certain ratio to the size of the diffraction-limited spot, both in the object plane.

A technique for determining, without having to perform optical proximity correction, when the result of optical proximity correction will fail to meet the design requirements for printability. A disclosed embodiment has application to a process for producing a photomask for use in the printing of a pattern on a wafer by exposure with optical radiation to optically image the photomask on the wafer. A method is set forth for checking the printability of a target layout proposed for defining the photomask, including the following steps: deriving a system of inequalities that expresses a set of design requirements with respect to the target layout; and checking the printability of the target layout by determining whether the system of inequalities is feasible.

The present invention provides various methods / systems of optical imaging of subsurface anatomical structures and biomolecules utilizing red and infrared radiant energy. Also provided are various applications of such methods / systems in medical diagnosis and treatment.

New devices and methods are provided for noninvasive and noncontact real-time measurements of tissue blood velocity. The invention uses a digital imaging device such as a detector array that allows independent intensity measurements at each pixel to capture images of laser speckle patterns on any surfaces, such as tissue surfaces. The laser speckle is generated by illuminating the surface of interest with an expanded beam from a laser source such as a laser diode or a HeNe laser as long as the detector can detect that particular laser radiation. Digitized speckle images are analyzed using new algorithms for tissue optics and blood optics employing multiple scattering analysis and laser Doppler velocimetry analysis. The resultant two-dimensional images can be displayed on a color monitor and superimposed on images of the tissues.

A three dimensional imaging system is disclosed which includes a three dimensional display (12), three-dimensional calibration equipment (16), and one or more two-dimensional (15) or three dimensional (14) image scanners. The three-dimensional display (12) uses optical pulses (32a-32k) and a non linear optical mixer (18) to display a three-dimensional image (17). The three-dimensional image (17) is generated in voxels of the display volume (28) as the optical mixer (18) sweeps the display volume (28). The three-dimensional calibration equipment (16) uses a hologram projected proximal to a desired object (164) to calibrate optical imaging devices (162a-162c) and to simplify the combination of the images from one or more optical imaging devices (162a-162c) into three-dimensional information. The three-dimensional image scanner (14) employs optical pulses (136, 138) and a non-linear optical mixer (128) to acquire three-dimensional images of a desired object (134). The three-dimensional image scanner (14) captures both the shape and color of a desired object (134).

Optical imaging systems are provided including a light source and a depolarizer. The light source is provided in a source arm of the optical imaging system. A depolarizer is coupled to the light source in the source arm of the optical imaging system and is configured to substantially depolarize the light from the light source. Related methods and controllers are also provided.

Chromophore probes that are capable of being taken up by, retained by or bound to a biocompatible molecule to form an imaging construct are provided. Various activation strategies of the resulting imaging construct are also provided.

Conventional electro-optical imaging systems can not achieve wide field of view (FOV) and high spatial resolution imaging simultaneously due to format size limitations of image sensor arrays. To implement wide field of regard imaging with high resolution, mechanical scanning mechanisms are typically used. Still, sensor data processing and communication speed is constrained due to large amount of data if large format image sensor arrays are used. This invention describes an electro-optical imaging system that achieves wide FOV global imaging for suspect object detection and local high resolution for object recognition and tracking. It mimics foveated imaging property of human eyes. There is no mechanical scanning for changing the region of interest (ROI). Two relatively small format image sensor arrays are used to respectively acquire global low resolution image and local high resolution image. The ROI is detected and located by analysis of the global image. A lens array along with an electronically addressed switch array and a magnification lens is used to pick out and magnify the local image. The global image and local image are processed by the processor, and can be fused for display. Three embodiments of the invention are described.

Embodiments of the invention relate to omni-tomographic imaging or grand fusion imaging, i.e., large scale fusion of simultaneous data acquisition from multiple imaging modalities such as CT, MRI, PET, SPECT, US, and optical imaging. A preferred omni-tomography system of the invention comprises two or more imaging modalities operably configured for concurrent signal acquisition for performing ROI-targeted reconstruction and contained in a single gantry with a first inner ring as a permanent magnet; a second middle ring containing an x-ray tube, detector array, and a pair of SPECT detectors; and a third outer ring for containing PET crystals and electronics. Omni-tomography offers great synergy in vivo for diagnosis, intervention, and drug development, and can be made versatile and cost-effective, and as such is expected to become an unprecedented imaging platform for development of systems biology and modern medicine.

An optical fiber scanner is used for multiphoton excitation imaging, optical coherence tomography, or for confocal imaging in which transverse scans are carried out at a plurality of successively different depths within tissue. The optical fiber scanner is implemented as a scanning endoscope using a cantilevered optical fiber that is driven into resonance or near resonance by an actuator. The actuator is energized with drive signals that cause the optical fiber to scan in a desired pattern at successively different depths as the depth of the focal point is changed. Various techniques can be employed for depth focus tracking at a rate that is much slower than the transverse scanning carried out by the vibrating optical fiber. The optical fiber scanner can be used for confocal imaging, multiphoton fluorescence imaging, nonlinear harmonic generation imaging, or in an OCT system that includes a phase or frequency modulator and delay line.

An intraocular camera for retinal prostheses may include an optical imaging system comprising a set of optical elements for forming an image of the external world on an image sensor array, wherein the optical elements and the image sensor array may be enclosed in an implantable biocompatible housing that may employ haptic elements for stabilization within the eye. The set of optical elements may be designed to have a short focal length and to provide adequate resolution images that can be transformed into a set of stimulation signals applied to a pixellated microstimulator array. Transmission of the signals from the intraocular camera to a microstimulator driver circuit may be accomplished either by a wired or wireless communication device. Power and control signals may be provided to the intraocular camera by a wired or wireless communication device, or optically by means of ambient illumination or an optical beam.

A method for detecting and localizing a target tissue within the body in the presence of ambient light in which an optical contrast agent is administered and allowed to become functionally localized within a contrast-labeled target tissue to be diagnosed. A light source is optically coupled to a tissue region potentially containing the contrast-labeled target tissue. A gated light detector is optically coupled to the tissue region and arranged to detect light substantially enriched in target signal as compared to ambient light, where the target signal is light that has passed into the contrast-labeled tissue region and been modified by the contrast agent. A computer receives signals from the detector, and passes these signals to memory for accumulation and storage, and to then to image processing engine for determination of the localization and distribution of the contrast agent. The computer also provides an output signal based upon the localization and distribution of the contrast agent, allowing trace amounts of the target tissue to be detected, located, or imaged. A system for carrying out the method is also described.