The invention relates to an online and offline integrated medicine query system. The system comprises a medical seeking system, a prescription medicine purchasing system, a chronic disease managementsystem, a non-prescription medicine purchasing system, a medical instrument/health care product purchasing system, an electronic prescription management system, an electronic prescription disassembling/distributing system, a distribution mode selection module, a pharmacist prescription checking module, a payment module, a logistics tracking system, a pharmacy GPS positioning system and an expressdelivery mode selection module. If a user passes the inquiry, a doctor issues an electronic prescription in the medical seeking system, and after disassembly, a branch store or a general store can check the prescription and select self-pickup or mailing. If a user needs to purchase prescription medicine, the user enters the prescription medicine purchasing system, and an electronic prescription can be issued in real time online after interrogation by doctors. If a user needs to purchase prescription medicine repeatedly, the user can upload family member information or retrieve the prescriptionin the electronic prescription management system. After a user purchases non-prescription medicine or medical instruments and health care products and completes payment, the drugstore mails the same.The system is simple and convenient to operate, avoids difficulty in buying medicine, and enables people to search for required medicine across regions and expands the medicine buying range.