1059 results about "Drug utilisation" patented technology

In the pharmaceutical research and development process, it may be necessary to process large amounts of medical records or clinical literature, to ensure safety of patients consuming a drug. A pharmacovigilance system may assist in this process by efficiently and automatically processing medical records to extract information and relationships contained therein and may also form a preliminary assessment regarding a medical or clinical judgment. The pharmacovigilance system may automatically generate reports based on this information, which may be validated by trained clinicians and medical experts.

The invention relates to an intelligent medicine box system. The intelligent medicine box system comprises a plurality of intelligent medicine boxes, a plurality of user terminals, a plurality of background management terminals, a cloud server and intelligent medicine box management software, wherein the intelligent medicine boxes are connected with the user terminals; the intelligent medicine boxes are connected with the cloud server; the cloud server is connected with the background management terminals and a database respectively; a plurality of functional modules are arranged in the intelligent medicine boxes; each functional module realizes the function thereof by virtue of the intelligent medicine box management software. The intelligent medicine box system provided by the invention is capable of realizing the functions of reminding a patient to take medicine on time, automatically recording a medicine-taking event and the like, is also capable of providing knowledge in the aspects of diseases, medicine curative effects, medicine safety and the like for the patient, thus fundamentally the compliance of the patient, and is further capable of helping the patient to actively record medicine-taking compliance data, and acquiring the medicine-taking experience data of the patient. The intelligent medicine boxes are capable of storing medicines according to the dosage of one week, and capable of adjusting the storage mode according to daily medicine-taking times, thus facilitating management.

A system integrates drug cumulative dosage monitoring, clinical information storage and workflow providing clinical notifications and worklists. The system monitors patient cumulative medication intake and includes at least one repository of information identifying medications and associated cumulative dosage limits for different time periods and for different types of patient. A monitoring processor, in response to a detected administration event indicating an additional dosage of a particular medication is to be administered to a particular patient, automatically determines whether a cumulative dosage, including the additional dosage, of the particular medication of the particular patient exceeds a cumulative dosage limit over a time period using information derived from the at least one repository. A notification processor automatically initiates generation of an alert message to at least one healthcare worker using a selected communication method The selected healthcare worker and the selected communication method is identified using predetermined notification configuration information.

The invention provides a method for intelligently computing the personalized rational medication time. The method comprises the steps of building a medication time related multi-dimensional attribute item dictionary, extracting medication time related element information, carrying out multi-dimensional processing on the medication time related element information, setting priorities of the medication time, extracting medication related element information of a patient, carrying out multi-dimensional processing on the medication related element information of the patient, setting the work and rest time of the patient, generating the rational medication time of a single drug, and generating the rational medication time of whole drugs of the patient. By implementation of the intelligent medication guiding method, system and equipment, massive medication data can be analyzed and processed through an information technology, and an intelligent medication guidance mode is provided.

The invention provides a small molecule drug in-situ phase-change gel sustained release agent with phospholipid and span as matrices and a preparation method thereof. By the adoption of the simple method, the phospholipid and span sustained release agent is prepared from phospholipid, span, active pharmaceutical ingredients and ethanol solutions of different concentrations, and has the advantages that the biocompatibility is good, the adverse reaction is low, the burst-release and inhibition capability is high, and the releasing time is prolonged; the sustained release agent is suitable for various drug administration modes such as subcutaneous injection and external drug administration, the amount of carried drugs can be adjusted conveniently according to the clinical medication dosage of the drugs, and the sustained release agent and the preparation method thereof have broad application prospects.

The invention relates to the technical field of intelligent medicine, and in particular relates to a medication reminding method and a client. The medication reminding method comprises the following steps: acquiring drug names; according to the drug names, inquiring medication information corresponding to the drug names in a medication database; and according to the medication information, and reminding medication. The medication reminding method provided by the invention achieves intelligent medication reminding on a user, so that the user can take drugs timely according to the reminding; therefore, medication efficacy is guaranteed.

The invention provides an anticancer intermediate based on PKI-587 and a polyethylene glycol coupled anticancer drug, and preparation methods and application thereof, belonging to the field of treatment of cancers. The anticancer intermediate has a general structural formula as described in the specification, and at least one AC in the general structural formula is the anticancer drug PKI-587. Thepolyethylene glycol coupled anticancer drug has a general structural formula as described in the specification. The above two drugs can realize combined medication of the targeting anticancer drug PKI-587 and a plurality of other anticancer drugs, so toxic response caused by mutual influence and pharmacokinetics of a plurality of other anticancer drugs can be prevented during individual administration of the anticancer drugs, multidrug resistance of cancers is overcome, and synergistic effect is exerted; and the two drugs can be used for preparing anticancer drugs with targeting effect and have critical clinical value and wide market prospects.

The invention discloses a multi-source data assisted clinical decision support system and method. The system comprises a medical/pharmaceutical data storage unit, a clinical pathway/evidence storage unit, an information input unit, a comparison processor unit, a diagnosis and treatment result output unit and an early warning and operation recording unit. According to the multi-source data assisted clinical decision support system and method of the invention, feasible clinical diagnosis and treatment scheme suggestions and corresponding clinical research and real world research evidence support are provided for medical workers, the whole disease cycle of diagnosis, treatment, prognosis, out-of-hospital management, disease burden and the like is covered, and doctors are assisted to quickly improve the clinical diagnosis and treatment level; the contradiction that time and energy of medical workers are difficult to keep up with clinical research progress is solved, and medical resources are balanced. After the system is deployed to a hospital end, when a doctor makes a prescription, the system can carry out reasonable early warning on treatment and medication schemes specifically involved in a clinical path; based on individual differences of patients, the reasonability and safety of the medication schemes are ensured, and the overall medical service quality is improved.

The invention discloses an intelligent drug guidance method, system and device. The method comprises the following steps: establishing a drug use database, extracting prescription information, carrying out prescription auditing, comparing patient basic information, drug information and patient drug use related element actual information with reasonable drug use guidance related information and rules in the drug use database, and obtaining and outputting drug use guidance information. The method, system and equipment for intelligent medicine guidance are used for assisting or replacing pharmaceutical workers to provide personalized medicine auditing and medication guidance for the patient, can improve the safety, effectiveness, economy and convenience of patient medication can be improved,and can enable medical institutions and retail drugstores of different levels to break through the limitation of professional resources and share professional data and business experience; meanwhile,the working efficiency of the pharmacy personnel can be greatly improved, the problem of insufficient pharmacist resources is effectively relieved, and the accessibility of patient pharmacy services is achieved.

The invention belongs to the field of neurological and psychiatric gene detection and particularly relates to a high-throughout sequencing method of genes relative to neurological and psychiatric drugs and application of the high-throughout sequencing method. The invention provides the high-throughout sequencing method of the genes relative to the neurological and psychiatric drugs and the application of the high-throughout sequencing method. The method comprises the following steps of acquisition of a genome DNA, target gene multiplex PCR amplification reaction and product purification, linker sequence PCR reaction and product purification, library detection, high-throughout sequencing and the like. The method can be used for detecting 29 SNP loci of 20 genes relative to drugs for neurological and psychiatric diseases at one time, can cover a vast majority of first-line and second-line drugs for resisting schizophrenia, depression, anxiety, epilepsy, Parkinson's disease, hyperkineticdisorder, pains and the like and provides guidance to medication of a patient to the maximum.

The invention relates to the field of tumor gene, and discloses a high-flux sequencing detection method for tumor-targeted drugs related genes mutation, a group of primer pairs and a reagent thereof. The method is used for detecting mutation of tumor-targeted drugs related genes in an acceptor, the related genes comprise BRAF, EGFR, KRAS, NRAS, TP53, FGFR3, KIT, PIK3CA, RET, PTEN, and CTNNB1. The method comprises the following steps: extraction of sample DNA, target gene enrichment, primer sequence removal, joint connection, PCR amplification, library homogenization, library detection and high flux sequencing. The disclosed primer pairs enable multiple PCR enrichment and amplification on the tumor-targeted drugs related genes, the method can be used for detecting 115 mutation sites in the above 11 genes, a detection result can be a medication guidance for the tumor-targeted drugs, and provides a basis for exploitation of novel cancer drugs.

The invention discloses a method, system and device for managing a rule base of a reasonable medication system. The method comprises the steps of: marking each reasonable medication rule in a drug usedatabase according to the source and content of the rule, selecting a proper reasonable medication rule by the user according to the own business requirement and the mark, generating a user-defined reasonable medication rule library meeting the user requirement, and applying the user-defined reasonable medication rule library to the reasonable medication system of the user. According to the method, the system and the device for managing a rule base of a reasonable medication system, the user can select a data set meeting own requirements as a built-in rule standard source of the medication management and control system based on the current situation of reasonable medication of different business units, and the data set can be adjusted in real time, so that a reasonable medication informatization rule management system is quickly established by taking a reasonable medication management and control requirement as a target, and the aims of improving the medication safety of a patient, improving the medical quality, reducing unreasonable medical expenses and reasonably distributing medical resources are fulfilled.

The invention relates to a quality control method for a Liuwei Anxiao traditional Chinese medicine preparation, belonging to the technical field of drugs. The Liuwei traditional Chinese medicine preparation is obtained by utilizing elecampane, myrobalam, rhubarb and other traditional Chinese medicinal materials, has the efficacies of improving the functions of the stomach and the spleen, promoting digestion, removing food retention, promoting blood circulation and stopping pains, and is frequently applicable to sufferers of stomachache, gastrectasia, indigestion, constipation, dysmenorrheal and other symptoms. The quality control method provided by the invention provides a detection index, a detection measure, a technical method, and the like for relevant production and detection institutions so as to better control the quality of the traditional Chinese medicine preparation, ensure the safety of medicine taking, better guide production, cause the production technique to be more rigidly and reasonably controlled and cause consumers to comprehensively know the product quality.

The invention relates to a stable parecoxib sodium pharmaceutical composition for injection. The pharmaceutical composition specifically comprises parecoxib sodium and additive for injection, wherein the additive at least contains a phosphatic buffer with a pH of 7.8-8.0, and other additive is selected from mannitol and sodium hydroxide. The parecoxib sodium pharmaceutical composition for injection provided by the invention is filled in a colorless neutral borosilicate glass tube injection bottle, has good stability, stable pH and little stimulation on skin, and is convenient for transportation and storage. The parecoxib sodium pharmaceutical composition for injection provides reasonable preparation prescription and preparation technology for clinical medicament usage and is easy for realization of industrialization.

The embodiment of the invention provides a medication guidance query method and device based on a knowledge graph, and belongs to the technical field of medical artificial intelligence. The method comprises the steps of pushing a corresponding interaction template to a user side in response to a query request sent by the user side; acquiring interaction information fed back by the user side through the interaction template, and generating a user portrait corresponding to the user side according to the interaction information; and generating medication information according to the user portraitand a pre-established drug knowledge graph, and feeding back the medication information to the user side. According to the technical scheme, the interaction information of a user is obtained throughthe interaction template to construct a user portrait of the user in real time, and based on the pre-established drug knowledge graph, the medication information is generated for the user portrait andrecommended to the user; the problem that a search mode based on word matching can only recommend a large drug candidate list due to the fact that the obtained user information is too little is effectively solved.

The invention discloses a clinical intelligent decision-making platform, which comprises a target parameter collection module used for collecting the medical history, medication history, current examination report, current physical state, medication allergy history, and details of a currently taken medicine of a patient; a treatment curve drawing module used for drawing a treatment curve accordingto the medical history and the medication history of the patient so as to obtain effective medicine components; a medicine recommendation module used for obtaining recommended medicines based on a BPneural network model according to the current examination report of the patient; and a medicine taking guidance module used for outputting a corresponding medicine taking guidance opinion according to the current examination report of the patient and the medicine recommended by the medicine recommendation module. According to the invention, accurate medication guidance can be output according todifferent conditions and requirements of patients, targeted medication can be realized while the workload of doctors can be reduced, damage to the bodies of the patients due to medication errors can be reduced, and the medicine effect can be improved.

The invention provides a semantic similarity-based personalized traditional Chinese medicine diagnosis and treatment information and traditional Chinese medicine information intelligent matching method. The method comprises the following steps: firstly, training a neural network model, and extracting semantic relationships among traditional Chinese medicine four-diagnosis information of symptoms,tongue veins and the like, syndromes, diseases, traditional Chinese medicines or prescriptions, treatment methods and other terms; on the basis, defining matching between personalized traditional Chinese medicine diagnosis and treatment information and indication and contraindication information of traditional Chinese medicine (Chinese patent medicine), wherein the matching of the diagnosis and treatment information and the indications comprises semantic similarity scores of the indications, key verb matching, key syndrome term matching and key disease term matching, and the matching of the diagnosis and treatment information and the contraindication comprises contraindication term matching. According to the method, on the basis of the semantic relation, through a series of key term matching, a correct matching result is amplified, and a matching result with a prohibited medication risk is punished, so that intelligent matching of personalized traditional Chinese medicine diagnosis andtreatment information and traditional Chinese medicine or Chinese patent medicine information is realized, and the unreasonable utilization rate of traditional Chinese medicine or Chinese patent medicine clinically is expected to be reduced.

The invention relates to the field of data processing, discloses a prescription medication auditing method, device and equipment and a storage medium, and is applied to the field of smart medical treatment. According to the method, prescription information and diagnosis information are extracted from medical data of a patient; medicine feature information is extracted based on the prescription information; based on the medicine feature information and the diagnosis information, the matching degree of a medicine and the diagnosis information is calculated by utilizing an indication identification module; an expert rule base and a medical ontology knowledge base are integrated based on the matching degree; and the medication in the prescription information is audited so as to obtain the auditing result of the medication in the prescription. According to the invention, the detection rate and accuracy of mismatching of the medicine and indications are greatly improved, false negative and false positive prompts are reduced, the influence on normal diagnosis and treatment behaviors of doctors is reduced, complex clinical scenes of hospitals are met, the satisfaction degree of users is improved, medicine taking errors are reduced, and the medicine taking safety of patients is guaranteed. The invention also relates to a block chain technology, wherein the medicine feature information can be stored in the block chain.

The invention relates to the field of data processing, discloses a medication recommendation method, a device and equipment and a storage medium, and is applied to the field of smart medical treatment. According to the method, a diagnosis result is input into a drug recommendation model for drug matching, a candidate drug list is obtained, screening is carried out based on the candidate drug listin combination with inquiry data, recommended drugs are obtained, and finally, drugs meeting conditions are selected based on the actual situation of a patient and stored in an inquiry list for subsequent use and consultation. In this way, automatic drug recommendation is achieved, the phenomenon that a doctor does not use drugs due to wrong memory of drug properties of the drugs is avoided, whenthe doctor issues the prescription, the doctor can rapidly determine the corresponding treatment prescription according to the recommended drugs in the inquiry list, and therefore the diagnosis efficiency of the doctor is improved. In addition, the invention also relates to a blockchain technology, and the diagnosis result, the candidate drug list and the drug recommendation result can be stored in the blockchain.