1085 results about "Drug utilisation" patented technology

In the pharmaceutical research and development process, it may be necessary to process large amounts of medical records or clinical literature, to ensure safety of patients consuming a drug. A pharmacovigilance system may assist in this process by efficiently and automatically processing medical records to extract information and relationships contained therein and may also form a preliminary assessment regarding a medical or clinical judgment. The pharmacovigilance system may automatically generate reports based on this information, which may be validated by trained clinicians and medical experts.

The invention relates to an intelligent medicine box system. The intelligent medicine box system comprises a plurality of intelligent medicine boxes, a plurality of user terminals, a plurality of background management terminals, a cloud server and intelligent medicine box management software, wherein the intelligent medicine boxes are connected with the user terminals; the intelligent medicine boxes are connected with the cloud server; the cloud server is connected with the background management terminals and a database respectively; a plurality of functional modules are arranged in the intelligent medicine boxes; each functional module realizes the function thereof by virtue of the intelligent medicine box management software. The intelligent medicine box system provided by the invention is capable of realizing the functions of reminding a patient to take medicine on time, automatically recording a medicine-taking event and the like, is also capable of providing knowledge in the aspects of diseases, medicine curative effects, medicine safety and the like for the patient, thus fundamentally the compliance of the patient, and is further capable of helping the patient to actively record medicine-taking compliance data, and acquiring the medicine-taking experience data of the patient. The intelligent medicine boxes are capable of storing medicines according to the dosage of one week, and capable of adjusting the storage mode according to daily medicine-taking times, thus facilitating management.

The invention discloses a doctor advice intelligent auditing system and method based on drug rule combination. The system comprises doctor advice basic rule base and rule combination library maintenance module, a doctor advice extraction module, a doctor advice checking module, a label printing (two-dimensional code generation) module and a departmental scanning module. The doctor advice extraction module is used for extracting information of doctor advices from electronic medical records; the doctor advice checking module performs checking in the mode of repeated dosage checking, combination rule joint checking and incompatibility checking to find checking alarm information to send the information to a clinical pharmacist for confirmation, and drugs with problems are turned down to a doctor; the doctor advise basic rule base and rule combination library maintenance module is used for maintaining and updating a combination library; the label printing module is used for labeling checked drugs to generate two-dimensional codes; the departmental scanning module performs departmental scanning on the two-dimensional codes of the drugs when the drugs depart. The doctor advice intelligent auditing system is used for recording the departmental time of the checked drugs and tracking the using process of drugs conveniently.

The invention relates to a prescription and a preparation method of rejoicing powder having a new dosage form and used for preventing or treating the senile dementia, and belongs to the biological medicine field. The rejoicing powder having a new dosage form is based on rejoicing powder having an ancient classic prescription and treats Radix Polygalae, Acorus gramineus and the like as primary medicines, the primary medicines are pretreated, partial or all medicines are extracted with water or an organic solvent in necessity to obtain effective components, the primary medicines or the effective components are mixed with proper medicinal auxiliary materials, and the rejoicing powder having the new dosage form is prepared through a certain preparation technology. The traditional prescription and the traditional technology for preparing the powder through simply crushing all medicines are changed in the invention, a new method and a new technology are applied against modern clinic medicine use characteristics to prepare the novel powder, and technological products have the characteristics of safety, effectiveness, controllable quality, convenient taking and the like of modern medicines, have the advantages of high biological utilization degrees of the effective components, fast effectiveness, substantial improvement of the product quality, and effective guarantee of the basic efficacies comprising qi benefiting, heart nourishing, nerve calming and tranquilizing, and have unique clinic application values in the prevention and the treatment of the senile dementia.

A system automatically updates a patient medication administration schedule in response to a healthcare worker entering data into an information system identifying a time at which a medication was administered to the patient. A medication administration information system comprises a processor for maintaining a schedule identifying a first nominal time for administering a first medication to a patient. The first medication is scheduled for administration to the patient subsequent to administration of a second medication to the patient. The processor updates the schedule by re-calculating the first nominal time for administering the first medication to the patient to provide a re-calculated time in response to received information identifying at least one of, (a) a late administration of the second medication to the patient and (b) an early administration of the second medication to the patient. The late and early administration being relative to a second scheduled nominal time for administering the second medication to the patient. A display generator initiates generation of data representing at least one display image including the re-calculated time for administering the first medication to the patient.

A system integrates drug cumulative dosage monitoring, clinical information storage and workflow providing clinical notifications and worklists. The system monitors patient cumulative medication intake and includes at least one repository of information identifying medications and associated cumulative dosage limits for different time periods and for different types of patient. A monitoring processor, in response to a detected administration event indicating an additional dosage of a particular medication is to be administered to a particular patient, automatically determines whether a cumulative dosage, including the additional dosage, of the particular medication of the particular patient exceeds a cumulative dosage limit over a time period using information derived from the at least one repository. A notification processor automatically initiates generation of an alert message to at least one healthcare worker using a selected communication method The selected healthcare worker and the selected communication method is identified using predetermined notification configuration information.

Traditional Chinese medicine formula granules are a new product, can replace traditional Chinese medicine decoction pieces for compatibility of traditional Chinese medicine decoctions, have the advantages of being convenient, time-saving, land-saving, small-dosage, and the like, are increasingly welcomed by patients, and are undoubtedly a favorable to the people. But traditional Chinese medicine formula granules have no uniform national quality standards and no uniform industry standards, so that confusion in circulation and use of the traditional Chinese medicine formula granules is caused. With the release of production and application of the traditional Chinese medicine decoction piece granules, the confusion in circulation and use of the traditional Chinese medicine formula granules is more severe. A uniform, controllable and feasible quality standard for the traditional Chinese medicine formula granules is researched and established based on the confusion in circulation and use of the traditional Chinese medicine formula granules, and the uniform, controllable and feasible quality standard for the traditional Chinese medicine formula granules is facilitates normal and healthy development of the traditional Chinese medicine formula granules, and can ensure safe and effective drug use of the patients.

The invention provides a method for intelligently computing the personalized rational medication time. The method comprises the steps of building a medication time related multi-dimensional attribute item dictionary, extracting medication time related element information, carrying out multi-dimensional processing on the medication time related element information, setting priorities of the medication time, extracting medication related element information of a patient, carrying out multi-dimensional processing on the medication related element information of the patient, setting the work and rest time of the patient, generating the rational medication time of a single drug, and generating the rational medication time of whole drugs of the patient. By implementation of the intelligent medication guiding method, system and equipment, massive medication data can be analyzed and processed through an information technology, and an intelligent medication guidance mode is provided.

An automated system for use by pharmacies, clinics or health care institutions which provides health information that comprises disease state information, the system having:a) a clinic computer having access to medical information containing a medication profile for the patient, andb) a remote computer having access to a drug-disease databaseThe disease state information being determined by a process where the clinic computer analyzes the medication information, creating a data packet comprising drug products being used, associating a unique identification number (UIDN) to the patient and data packet, and transmitting the UIDN and data packet to the remote computer. The remote computer then cross-referencing the drug products contained within said data packet with individual disease states and identifying disease state information that is relevant to be provided to a patient.

The invention provides a small molecule drug in-situ phase-change gel sustained release agent with phospholipid and span as matrices and a preparation method thereof. By the adoption of the simple method, the phospholipid and span sustained release agent is prepared from phospholipid, span, active pharmaceutical ingredients and ethanol solutions of different concentrations, and has the advantages that the biocompatibility is good, the adverse reaction is low, the burst-release and inhibition capability is high, and the releasing time is prolonged; the sustained release agent is suitable for various drug administration modes such as subcutaneous injection and external drug administration, the amount of carried drugs can be adjusted conveniently according to the clinical medication dosage of the drugs, and the sustained release agent and the preparation method thereof have broad application prospects.

The invention relates to the technical field of intelligent medicine, and in particular relates to a medication reminding method and a client. The medication reminding method comprises the following steps: acquiring drug names; according to the drug names, inquiring medication information corresponding to the drug names in a medication database; and according to the medication information, and reminding medication. The medication reminding method provided by the invention achieves intelligent medication reminding on a user, so that the user can take drugs timely according to the reminding; therefore, medication efficacy is guaranteed.

A medication information acquisition system facilitates collection and accurate consolidation of home medication history from data sources providing data of varying degrees of accuracy. A medication information acquisition system automatically acquires patient medication information from multiple different sources. The system includes an acquisition processor for, in response to user command, automatically interrogating multiple different information sources for acquiring and collating medication data to provide patient medication history data indicating medications a patient received prior to admission to a healthcare provider facility. The multiple different information sources include at least two of, (a) a pharmacy benefit management system, (b) a healthcare information system indicating medications a patient was receiving at the most recent time of discharge of the patient from a healthcare provider facility and (c) medication information derived by questioning the patient. A display processor initiates generation of data representing a display image identifying the medications the patient received prior to admission and enabling a user to individually select medications to be continued or canceled.

A system and method for increasing patient adherence to following medication treatment regimens. An adherence data processing and communication system generates and displays medication adherence data based on historical medication information. The system is linked to other systems involved with electronic ordering and filling of prescriptions, such as electronic prescription and pharmacy systems all connected by suitable wired and / or wireless communication protocols including the Internet. In one embodiment, the adherence data is displayed in the form of an interactive report card which provides a user with adherence metrics in both summary and more detailed formats for prescription medications taken by the patient. A related method executed by the data processing and communication system is disclosed.

The invention provides an anticancer intermediate based on PKI-587 and a polyethylene glycol coupled anticancer drug, and preparation methods and application thereof, belonging to the field of treatment of cancers. The anticancer intermediate has a general structural formula as described in the specification, and at least one AC in the general structural formula is the anticancer drug PKI-587. Thepolyethylene glycol coupled anticancer drug has a general structural formula as described in the specification. The above two drugs can realize combined medication of the targeting anticancer drug PKI-587 and a plurality of other anticancer drugs, so toxic response caused by mutual influence and pharmacokinetics of a plurality of other anticancer drugs can be prevented during individual administration of the anticancer drugs, multidrug resistance of cancers is overcome, and synergistic effect is exerted; and the two drugs can be used for preparing anticancer drugs with targeting effect and have critical clinical value and wide market prospects.

The invention relates to a quality control method of a-l tonic traditional Chinese medicine medicament for lingering deficiency of vital energy and deficiency of qi and yin, belonging to the technical field of drug. The a-l tonic traditional Chinese medicine medicament consists of astragalus root and ligustrum japonicum and other Chinese medicinal materials. The invention has the effects of boosting qi and nourishing yin, enhancing body immunity, protecting marrow and adrenal cortex and is suitable for patients with lingering deficiency of vital energy and deficiency of qi and yin and other symptoms. Currently, the invention is widely used for matching operation, radiation therapy and chemotherapy and promoting recovery of normal function and the like in clinic. The invention provides a quality control method of a-l tonic traditional Chinese medicine medicament for lingering deficiency of vital energy and deficiency of qi and yin, which provides index and way of testing and technical method, etc. for appropriate producing and detecting institutions, thereby being convenient to control quality of tradition Chinese medicine medicament, ensure dosage safety, supervise production, more strictly and reasonably control production process, and completely recognize quality of products for customers.

The invention discloses a multi-source data assisted clinical decision support system and method. The system comprises a medical / pharmaceutical data storage unit, a clinical pathway / evidence storage unit, an information input unit, a comparison processor unit, a diagnosis and treatment result output unit and an early warning and operation recording unit. According to the multi-source data assisted clinical decision support system and method of the invention, feasible clinical diagnosis and treatment scheme suggestions and corresponding clinical research and real world research evidence support are provided for medical workers, the whole disease cycle of diagnosis, treatment, prognosis, out-of-hospital management, disease burden and the like is covered, and doctors are assisted to quickly improve the clinical diagnosis and treatment level; the contradiction that time and energy of medical workers are difficult to keep up with clinical research progress is solved, and medical resources are balanced. After the system is deployed to a hospital end, when a doctor makes a prescription, the system can carry out reasonable early warning on treatment and medication schemes specifically involved in a clinical path; based on individual differences of patients, the reasonability and safety of the medication schemes are ensured, and the overall medical service quality is improved.

The invention relates to a testing method of CYP2D6 gene exon 9's single nucleotide polymorphism, and meanwhile relates to a separation nucleic acid and an allel-specific nucleic acid primer. The method comprises steps as described below: firstly the confirmation of the 1332 nucleic acid showed in the SEQ ID No: 1 in the human CYP2D6 gene exon 9, then test of the existence of the single nucleotide polymorphism, specifically a separation nucleic acid with the SEQ ID NO: 1 and the 1322 position is A, an allel-specific nucleic acid primer with the length of 15 to 50bp and specifically hybridizes and amplifies the amplified products of the 1322 nucleic acid polymorphism showed in the SEQ ID No: 1 in the human CYP2D6 gene exon 9. The invention can be used to research the relation between CYP2D6 gene polymorphism in Chinese people and the clinical drug safety, and provide guidance to the development of new drugs.

The invention discloses an intelligent drug guidance method, system and device. The method comprises the following steps: establishing a drug use database, extracting prescription information, carrying out prescription auditing, comparing patient basic information, drug information and patient drug use related element actual information with reasonable drug use guidance related information and rules in the drug use database, and obtaining and outputting drug use guidance information. The method, system and equipment for intelligent medicine guidance are used for assisting or replacing pharmaceutical workers to provide personalized medicine auditing and medication guidance for the patient, can improve the safety, effectiveness, economy and convenience of patient medication can be improved,and can enable medical institutions and retail drugstores of different levels to break through the limitation of professional resources and share professional data and business experience; meanwhile,the working efficiency of the pharmacy personnel can be greatly improved, the problem of insufficient pharmacist resources is effectively relieved, and the accessibility of patient pharmacy services is achieved.

The invention belongs to the field of neurological and psychiatric gene detection and particularly relates to a high-throughout sequencing method of genes relative to neurological and psychiatric drugs and application of the high-throughout sequencing method. The invention provides the high-throughout sequencing method of the genes relative to the neurological and psychiatric drugs and the application of the high-throughout sequencing method. The method comprises the following steps of acquisition of a genome DNA, target gene multiplex PCR amplification reaction and product purification, linker sequence PCR reaction and product purification, library detection, high-throughout sequencing and the like. The method can be used for detecting 29 SNP loci of 20 genes relative to drugs for neurological and psychiatric diseases at one time, can cover a vast majority of first-line and second-line drugs for resisting schizophrenia, depression, anxiety, epilepsy, Parkinson's disease, hyperkineticdisorder, pains and the like and provides guidance to medication of a patient to the maximum.

The invention relates to the field of tumor gene, and discloses a high-flux sequencing detection method for tumor-targeted drugs related genes mutation, a group of primer pairs and a reagent thereof. The method is used for detecting mutation of tumor-targeted drugs related genes in an acceptor, the related genes comprise BRAF, EGFR, KRAS, NRAS, TP53, FGFR3, KIT, PIK3CA, RET, PTEN, and CTNNB1. The method comprises the following steps: extraction of sample DNA, target gene enrichment, primer sequence removal, joint connection, PCR amplification, library homogenization, library detection and high flux sequencing. The disclosed primer pairs enable multiple PCR enrichment and amplification on the tumor-targeted drugs related genes, the method can be used for detecting 115 mutation sites in the above 11 genes, a detection result can be a medication guidance for the tumor-targeted drugs, and provides a basis for exploitation of novel cancer drugs.

The invention discloses a VR cardiac surgery simulation system. The system comprises a simulation server, a surgical operation device, a medication operation device, a virtual database and a live-action data generation unit. The virtual database is connected with a communication interface. An operation data acquisition device and an operation data communication module are sequentially connected between the surgery operation device and the live-action data generation unit. A medication flow acquisition device and a medication flow communication module are sequentially connected between the medication operation device and the live-action data generation unit. The invention further discloses a VR cardiac surgery simulation method. According to the invention, the collected data of a myocardialpressure detection module and the action state data of the surgical operation device are responded by the medication operation model, the surgical operation model and heart simulation data which arestored in a virtual database. In this way, a virtual-real hybrid simulation scene is obtained, so that the technical effect of combining actual operation and the virtual scene is achieved. The preoperative scheme design is facilitated. The growth of surgeons in practice is facilitated, and the use effect is good.

The invention provides a drug information management method, a device and a system, wherein the method is executed by a server; the server is connected with a supply chain client, a hospital client and a patient client; the method includes steps of receiving an identification code and stock information of a drug uploaded by the supply chain client, wherein the stock information comprises stock pharmacy and stock time of the drug; receiving the drug prescription record uploaded by the hospital client, wherein the prescription record comprises disease type, doctor for providing the prescription, and the drug receiving record; receiving the drug taking record and the drug effect feedback information uploaded by the patient client; according to the drug identification code, binding and storing the stock information, prescription record, drug taking record and drug effect feedback information of the drug, and generating a full life cycle management report of the drug. The drug information management method, the device and the system can record the full-process data of the drug from production, sales to the drug feedback of a patient; a user can comprehensively master related information of the drug, thus the full-process traceability of the drug information is realized.

The embodiment of the invention provides a personalized precise medication recommendation method and device, and relates to the technical field of base frame operation and maintenance. The method comprises the steps: obtaining medical record data of a plurality of patients suffering from the same disease, wherein the medical record data comprises structural data, text data and image data; obtaining medication information of the patient from the text data; screening from the medication information of the plurality of historical patients to obtain a first medicine recommendation result of a target patient; merging the medical record data of the patient to obtain disease characteristic information of the patient; screening out at least one similar patient similar to the current illness statecharacteristic information of the target patient from the plurality of historical patients; generating a second medicine recommendation result according to the medication information of the similar patients; and obtaining a personalized medicine recommendation result of the target patient according to the first medicine recommendation result and the second medicine recommendation result. Accordingto the technical scheme provided by the embodiment of the invention, the problem of low medication accuracy of the patients in the prior art can be solved.

The invention discloses a method, system and device for managing a rule base of a reasonable medication system. The method comprises the steps of: marking each reasonable medication rule in a drug usedatabase according to the source and content of the rule, selecting a proper reasonable medication rule by the user according to the own business requirement and the mark, generating a user-defined reasonable medication rule library meeting the user requirement, and applying the user-defined reasonable medication rule library to the reasonable medication system of the user. According to the method, the system and the device for managing a rule base of a reasonable medication system, the user can select a data set meeting own requirements as a built-in rule standard source of the medication management and control system based on the current situation of reasonable medication of different business units, and the data set can be adjusted in real time, so that a reasonable medication informatization rule management system is quickly established by taking a reasonable medication management and control requirement as a target, and the aims of improving the medication safety of a patient, improving the medical quality, reducing unreasonable medical expenses and reasonably distributing medical resources are fulfilled.

The invention relates to a quality control method for a Liuwei Anxiao traditional Chinese medicine preparation, belonging to the technical field of drugs. The Liuwei traditional Chinese medicine preparation is obtained by utilizing elecampane, myrobalam, rhubarb and other traditional Chinese medicinal materials, has the efficacies of improving the functions of the stomach and the spleen, promoting digestion, removing food retention, promoting blood circulation and stopping pains, and is frequently applicable to sufferers of stomachache, gastrectasia, indigestion, constipation, dysmenorrheal and other symptoms. The quality control method provided by the invention provides a detection index, a detection measure, a technical method, and the like for relevant production and detection institutions so as to better control the quality of the traditional Chinese medicine preparation, ensure the safety of medicine taking, better guide production, cause the production technique to be more rigidly and reasonably controlled and cause consumers to comprehensively know the product quality.

The invention relates to a stable parecoxib sodium pharmaceutical composition for injection. The pharmaceutical composition specifically comprises parecoxib sodium and additive for injection, wherein the additive at least contains a phosphatic buffer with a pH of 7.8-8.0, and other additive is selected from mannitol and sodium hydroxide. The parecoxib sodium pharmaceutical composition for injection provided by the invention is filled in a colorless neutral borosilicate glass tube injection bottle, has good stability, stable pH and little stimulation on skin, and is convenient for transportation and storage. The parecoxib sodium pharmaceutical composition for injection provides reasonable preparation prescription and preparation technology for clinical medicament usage and is easy for realization of industrialization.

The embodiment of the invention provides a medication guidance query method and device based on a knowledge graph, and belongs to the technical field of medical artificial intelligence. The method comprises the steps of pushing a corresponding interaction template to a user side in response to a query request sent by the user side; acquiring interaction information fed back by the user side through the interaction template, and generating a user portrait corresponding to the user side according to the interaction information; and generating medication information according to the user portraitand a pre-established drug knowledge graph, and feeding back the medication information to the user side. According to the technical scheme, the interaction information of a user is obtained throughthe interaction template to construct a user portrait of the user in real time, and based on the pre-established drug knowledge graph, the medication information is generated for the user portrait andrecommended to the user; the problem that a search mode based on word matching can only recommend a large drug candidate list due to the fact that the obtained user information is too little is effectively solved.

The invention discloses a clinical intelligent decision-making platform, which comprises a target parameter collection module used for collecting the medical history, medication history, current examination report, current physical state, medication allergy history, and details of a currently taken medicine of a patient; a treatment curve drawing module used for drawing a treatment curve accordingto the medical history and the medication history of the patient so as to obtain effective medicine components; a medicine recommendation module used for obtaining recommended medicines based on a BPneural network model according to the current examination report of the patient; and a medicine taking guidance module used for outputting a corresponding medicine taking guidance opinion according to the current examination report of the patient and the medicine recommended by the medicine recommendation module. According to the invention, accurate medication guidance can be output according todifferent conditions and requirements of patients, targeted medication can be realized while the workload of doctors can be reduced, damage to the bodies of the patients due to medication errors can be reduced, and the medicine effect can be improved.