The invention discloses an adaptive path selection-based circRNA (Ribonucleic Acid) and
disease association relationship prediction method, which comprises the following steps of: downloading a
database for acquiring association relationships among circRNA, diseases and miRNA (Micro Ribonucleic Acid), and constructing an association matrix; downloading
disease description information, calculating and obtaining a
disease semantic similarity matrix, and averaging to obtain a disease fusion similarity; constructing a meta-path by using the association relationship and the disease fusion similarity; constructing an initialization graph according to the meta-path, and reconstructing a meta-path graph through a self-adaptive path
selection method; the reconstructed meta-
path diagram is sent to a
noise diagram contrast learning
algorithm for
feature extraction and fusion; according to the method, multi-dimensional graph comparison features are fused through a multi-head attention mechanism, an MLP is used for classification, three losses in training are fused for iterative optimization until
algorithm convergence, the MLP is used for final classification, and the incidence relation between circRNA ci and a disease d is predicted. The invention further discloses a
system and application for realizing the prediction method, and the
system and the application have wide application scenes.