252 results about "Synthetic drugs" patented technology

A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are alpha1-antitrypsin and synthetic drugs mimicking some or all of the actions of alpha1-antitrypsin.

The invention discloses a livestock feed additive composition and the preparation method and the application thereof. The livestock feed additive composition comprises following ingredients by weight percentages: 70 to 90 percent of medicated leaven, 70 to 90 percent of sweetflag, 35 to 45 percent of tangerine peel, 35 to 45 percent of dyers woad leaves, 35 to 45 percent of isatis root, 25 to 35 percent of white peony, 25 to 35 percent of divaricate saposhnikovia root, 25 to 35 percent of fennel, 25 to 35 percent of liquorice and 90 to 110 percent of lack tartary buckwheat. The invention adopts natural Chinese herbal medicine, can fully avoid damaging human bodies by added chemical synthetic drugs and toxic chemical substances, does not generate the cross drug resistance of the drugs shared by human beings and livestock, is favorable to the enhancement of the organism immunity of livestock and improves the metabolism capability of the livestock so as to achieve the aims of resisting diseases and promoting the growth of the livestock .

The invention discloses a new method for synthesizing pranlukast, in particular to a method for synthesizing medicinal pranlukast from tetrahydrofuran. The method takes the tetrahydrofuran as raw materials to prepare the pranlukast through ring opening, Friedel-Crafts alkylation, bromination, condensation and ring closing reactions. The method has the characteristics of readily available raw materials, simple reaction for preparation of an intermediate, high yield, safe reactions and suitability for industrial production, and can be used to prepare the medicinal pranlukast for treating asthma and allergic rhinitis.

The invention relates to a process of a chemical synthesis medicament, in particular to a novel synthesis process of erlotinib hydrochloride serving as an antitumor medicament, and a novel intermediate. The process has the advantages of low-price and readily-available raw materials, mild conditions in a reacting process, no device with special requirements and suitability for industrial production.

The invention describes antibodies that bind molecules of the pyrrolidinophenone class of synthetic drugs. The antibodies are derived from novel chemical intermediates, haptens and immunogens and are used in methods and kits to detect and quantify pyrrolidinophenones.

The invention relates to the technical field of feed, in particular, to a compound plant extract feed additive and a preparation method thereof. The invention aims to provide a compound plant extract feed additive with a strong antibacterial effect for solving various defects such as existence of toxic and side effects caused by adding other synthetic drugs such as antibiotic in the feeds, and excellent effects are achieved. The technical scheme of the invention is to provide the compound plant extract feed additive, which comprises citrus essential oil, allicin, tangeritin, pine needle meal and pine flower essential oil. The compound plant extract feed additive has the following benefits: based on the traditional Chinese herbal medicine theoretical research and practice, 4 traditional Chinese herbal medicines and 5 extracts are chosen, the in-vitro antimicrobial activities thereof are measured, and plant extracts having restraining effect to aeromonas hydrophila are selected out to prepare compound preparation. The compound plant extract feed additive has the characteristics of excellent in-vitro antimicrobial activity, high efficiency, safety, no poison and no residue for long-time use.

The invention relates to a method for preparing pharmaceutical cocrystals through suspension crystallization. The method concretely comprises the following steps: firstly screening solid forms of active pharmaceutical ingredients API and cocrystal formation CCF in different solvents, preparing a CCF saturation solution together with a solvent which cannot generate solvate together with the API and CCF; feeding the prepared CCF saturation solution into a vessel type stirrer, feeding the solid API and CCF according to a certain solid load rate, and deciding the ratio of molar weight of the API and CCF according to the cocrysal chemical metrological ratio; and sampling to do XRD or DSC testing after fully stirring and mixing, so as to prove that the cocrystal solid phase is pure, performing vacuum filtration to the obtained solid, and washing and drying the CCF saturation solution to obtain a solid, namely a final cocrystal product. Compared with other methods, the method is low in energy consumption, less in used solvent, low in cost, simple in technology, easy to amplify, fast and easy to obtain, high in the purity of products, and suitable for industrial large-batch synthesized pharmaceutical cocrystals.

Disclosed is a novel synthetic method for isomeric peptides through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid. The novel synthetic method produces isomeric peptides of L-selenomethionine or Se-Methyl-L-selenocysteine that exhibit (i) enhanced water solubility; (ii) enhanced rate of dissolution in water; (iii) enhanced bioavailability; (iv) excellent vascular endothelial growth factor promoting activity; (v) excellent anti-5-alpha-reductase activity; (vi) capabilities to prevent/reduce “hair fall” and promote “hair growth”, thereby maintaining a perfect homeostasis for “hair care”. Cosmeceutical and pharmaceutical compositions comprising the isomeric peptides obtained through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid are also disclosed. Other dipeptides with several other amino acids and uses thereof are also disclosed.

The invention discloses sedative and hypnotic active saponin components of a spina date seed, as well as separation and purification method and application of the sedative and hypnotic active saponin components, and belongs to the field of separation of natural products. The invention designs a new and relatively safe extracting route without introducing obviously toxic solvents and agents. The separation and purification method is characterized by comprising the following steps of: extracting a spina date seed sedative and hypnotic active saponin sample from a spina date seed sample by the alcohol extraction method and n-butanol extraction method; and then separating spina date seed sedative and hypnotic active saponin components I and II from the saponin sample by the column chromatography and thin-layer chromatography. The two spina date seed saponin components separated from the spina date seed show obvious hypnotic activity; and the natural sedative and hypnotic active components extracted and separated from traditional Chinese medicine can be used for solving the problems of multiple side effects and addiction of chemical synthetic drugs and is beneficial to human health and contributed to all the society.

The invention discloses a traditional Chinese medicine compound feed for egg quails and a preparation method thereof and belongs to the field of quail feeds. The compound feed comprises the following components: 30-50 parts of extruded corn, 20-40 parts of fermented soybean meal, 10-15 parts of supper fish meal, 2-4 parts of soybean oil, 2-5 parts of grass seed powder, 2-3 parts of soybean oil cake, 5-7 parts of rice bran, 3-5 parts of table salt, 4-6 parts of premix and 0.5-1 part of traditional Chinese medicine additive. The preparation method comprises the following steps: (1) preparation of the premix; (2) extraction of a traditional Chinese medicine liquid; (3) refining of the traditional Chinese medicine liquid; (4) preparation of the traditional Chinese medicine additive; and (5) preparation of the traditional Chinese medicine compound feed. The feed disclosed by the invention has the advantages that the traditional Chinese medicine additive reasonable in formula is adopted, so that the egg laying rate of the egg quails is effectively increased and the death rate is reduced; no chemical synthetic drug such as antibiotic is contained in the feed, so that the additive entering the egg quail bodies is prevented from generating drug residue in quail eggs, the quality of the quail eggs is effectively kept and the quail eggs are healthy and safe to eat by people.

The invention discloses a feed for improving the quality and the flavor of pork. The feed contains a plurality of amino acid chelate microelements, vitamin, a plant extract and the like. The additive amount of organic microelements and inorganic microelements in the feed can be effectively reduced, the residual quantity of metal is reduced, the environmental pollution is alleviated and the ecological environment is protected. Meanwhile, the plant extract is reasonably matched, so that the carcass lean meat rate is significantly increased, the eye muscle area is increased, the carcass fat rate and backfat areim reduced, the flavor of the pork is improved, the quality of the pork is improved, the feed is capable of replacing antibiotics and a chemical synthetic drug feed additive to produce safe and excellent pork, and the problems that the pork is poor in quality, more in PSE meat and poor in flavor in current pig production are solved.

The invention belongs to the technical field of the organic synthetic chemistry and specifically relates to a simple and feasible method for synthesizing an imidazo[1,2-a]pyridine-3-formaldehyde compound through one step. The invention provides a method for synthesizing the imidazo[1,2-a]pyridine-3-formaldehyde compound through a [3+2] cyclization reaction of 2-aminopyridine and cinnamylaldehyde through one step; the method has the advantages that the raw materials are simple and easily available, the step is simple and efficient, multi-step synthesis of a reaction precursor is avoided, the reaction time is effectively shortened, the extended application range of the product is wide, and the like. In particular, due to the use of 2-aminopyridine/pyrazine, imidazo[1,2-a]pyridine/pyrazine derivatives can be synthesized through one step. The method provided by the invention is applicable to synthesizing various imidazo[1,2-a]pyridine compounds. Besides, the method is capable of effectively synthesizing drug molecules Alpidem and Zolipidem.

This invention relates to an organic iodine complex, in which iodine serves as coordination center and functional group-containing organics serve as chelating reagent. The functional groups can be amino and/or hydroxyl and/or carboxyl, and the representatives of hydroxyl- and carboxyl-containing organics are 2-hydroxy-4-methylthiobutanoic acid and 2-hydroxypropanoic acid, respectively. This invention also relates to a combination of organic iodine complex and its application in pharmacy. The combination comprises 0.3~40% organic iodine complex as active ingredient and one or more ingredients chosen from the following ones: natural aminoacyl iodine, solvent, surfactant, food additives, food and synthesized drugs. This combination can be used in preparation of drug against AIDS, white spot syndrome virus in penaeid shrimp, Taura syndrome virus; grass carp hemorrhage virus, stomatitis, pharyngitis, colpitis, tumor, digestive tract diseases in poultry, histomoniasis, coccidiosis, human digestive tract diseases and iodine deficiency diseases.

The invention relates to an anti-diarrhea feed additive for piglets. The anti-diarrhea feed additive for the piglets comprises the following ingredients: 30-50 parts of a plant essence oil mixture, 10-30 parts of a traditional Chinese medicine named herba portulacae, 10-25 parts of fructo-oligosaccharides, 10-25 parts of manno-oligosaccharides, 5-15 parts of sodium butyrate, 5-15 parts of citric acid, 5-15 parts of fumaric acid, 20-50 parts of maltodextrin, 5-15 parts of silicon dioxide and 60-95 parts of a montmorillonite powder carrier; and the plant essence oil mixture is prepared by mixing and blending the following raw materials: 4-10 parts of common origanum oil, 2-8 parts of clove oil and 2-8 parts of cinnamon oil. Being added into piglet feeds, the feed additive is capable of effectively improving piglet immunity, enhancing disease resistance and disease prevention abilities of the piglets, improving anti-stress abilities, reducing diarrhea occurrence rates of the piglets, and improving growth performances; the feed additive is free of any toxic side effects, and is safe and reliable to use; moreover, the feed additive can be used to replace veterinary antibiotics and other chemical synthetic drugs which are commonly used at present.

The present invention relates to drug derivatives and linkers. The invention specifically relates to compounds and methods of phosphonates and linkers, that are useful as carriers for imaging agents and useful in the treatment of various bone diseases.

The invention belongs to the field of synthetic drugs, and relates to an application of geniposide in alleviating side effects of glucocorticoid, and an application of compounds represented by the formula I or pharmaceutically acceptable salts, esters, or prodrugs in preparation of drugs for alleviating side effects of glucocorticoid. The molecular action mechanism of the compounds in alleviatingthe side effects of glucocorticoid drugs has important clinical significance for developing new drugs.

The invention discloses a gait balance training and testing device for improving a cognitive function of a synthetic drug addict. The device comprises a testing unit, a data conversion and output unit and a computer, wherein the testing unit comprises a physical footpath and a plurality of gait information detectors; a pedal surface is arranged on the physical footpath; the gait information detectors are arranged on the two sides of the walking direction of the physical footpath, and are connected with the data conversion and output unit; the data conversion and output unit is connected with the computer. According to the technical scheme, the gait information detectors are arranged on the two sides below the footpath on which a tested person walks, and are used for recording information about the falling of feet of the tested person off the footpath detection and evaluation when the tested person walks abnormally; when the device is applied to synthetic drug addict inpatients and outpatients of various drug addiction treatment institutions, the cognitive function of the synthetic drug addict can be effectively improved, and the device is significant for lowering the relapse rate and shortening the rehabilitation course.

The present invention relates to a new type pig feed. The new type pig feed mainly consists of the following raw materials in parts by weight: 50-80 parts of corn, 30-40 parts of wheat, 20-30 parts of soybean meal, 1-2 parts of phytase, 1-4 parts of threonine, 2-6 parts of choline, 1-3 parts of amylases, 2-4 parts of cellulases, 1.5-2.5 parts of lipase, 10-20 parts of bone meal, 20-40 parts of calcium dihydrogen phosphate, 5-10 parts of edible salt, 3-6 parts of sodium selenite, 10-20 parts of traditional Chinese medicinal composition additive, 25-35 parts of corn dried distiller's grains, 20-40 parts of corn soaking liquid sprayed corn husks, 20-40 parts of carrot residues, 10-30 parts of fish meal, 5-15 parts of betaine and 1-5 parts of vitamin mixture. The new type pig feed has the advantages of enhancing pig body immunity, improving pork quality, preventing and controlling diarrhea and diseases, and promoting pig growth, and can replace or partly replace the uses of antibiotics and chemically synthetic drugs.