263 results about "Synthetic drugs" patented technology

The invention provides a system and method utilizing, among other things, fluorescence spectroscopy in the ultraviolet portion of the electromagnetic spectrum to determine chemical species and concentrations. The basic measuring system includes optics, a spectrograph, a detector, and an energy source (“head” components), along with a computer and control electronics and power source capable of generating and detecting unique fluorescence signatures for individual and unique mixtures of chemical substances including, for example, prescribed and / or compounded medications, alcohol products, food types, synthetic drugs, narcotics, perfumes, liquids, and the like.

A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are alpha1-antitrypsin and synthetic drugs mimicking some or all of the actions of alpha1-antitrypsin.

The invention discloses a livestock feed additive composition and the preparation method and the application thereof. The livestock feed additive composition comprises following ingredients by weight percentages: 70 to 90 percent of medicated leaven, 70 to 90 percent of sweetflag, 35 to 45 percent of tangerine peel, 35 to 45 percent of dyers woad leaves, 35 to 45 percent of isatis root, 25 to 35 percent of white peony, 25 to 35 percent of divaricate saposhnikovia root, 25 to 35 percent of fennel, 25 to 35 percent of liquorice and 90 to 110 percent of lack tartary buckwheat. The invention adopts natural Chinese herbal medicine, can fully avoid damaging human bodies by added chemical synthetic drugs and toxic chemical substances, does not generate the cross drug resistance of the drugs shared by human beings and livestock, is favorable to the enhancement of the organism immunity of livestock and improves the metabolism capability of the livestock so as to achieve the aims of resisting diseases and promoting the growth of the livestock .

The invention discloses a new method for synthesizing pranlukast, in particular to a method for synthesizing medicinal pranlukast from tetrahydrofuran. The method takes the tetrahydrofuran as raw materials to prepare the pranlukast through ring opening, Friedel-Crafts alkylation, bromination, condensation and ring closing reactions. The method has the characteristics of readily available raw materials, simple reaction for preparation of an intermediate, high yield, safe reactions and suitability for industrial production, and can be used to prepare the medicinal pranlukast for treating asthma and allergic rhinitis.

The invention relates to a treatment method of wastewater produced by cephalo synthetic drug manufacturing, which mainly comprises three parts, namely, aerobe catalytic oxidation, anoxia hydrolytic acidification and a membrane biological reactor; firstly, organic matters having better biodegradability in the wastewater are removed in a biological contact oxidation pond, then biological hydrolytic acidification is carried out in an anoxic pond, and then the wastewater flows into the membrane biological reactor to carry out final aerobic Bioremediation; the wastewater after the treatment passes through an ultrafiltration membrane in the membrane biological reactor and is pumped out by a pump and then discharged to an effluent pipe after reaching standards or recycled to the production technology; the membrane biological reactor consists of an aeration zone and a membrane filtering zone, wherein, the aeration zone carries out aeration by adopting a disc-shaped millipore aeration head, the ultrafiltration membrane is positioned in the membrane filtering zone, the organic matters in the wastewater after being treated with aerobe contact oxidation and anoxia hydrolytic acidification are basically biodegraded, the wastewater is pumped out through the ultrafiltration membrane, and microbes in the reactor are blocked in the reactor. The method has the advantages of simple technique, good effect of treating wastewater, small occupation area, and low treatment cost, and is especially suitable for the wastewater produced by the cephalo synthetic drug manufacturing.

A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are alpha1-antitrypsin and synthetic drugs mimicking some or all of the actions of alpha1-antitrypsin.

The invention relates to a submicroemulsion antifungal drug spray preparation. The preparation mainly comprises the following components: an antifungal chemical synthetic drug, lecithin serving as an emulsifier, a transdermal absorption penetration enhancer and a skin protectant, soybean oil or other essential oils serving as an oil soluble diluent, glycerin serving as an isoosmotic adjusting agent, oleic acid serving as a co-emulsifier and a transdermal absorption penetration enhancer, azone serving as a transdermal absorption penetration enhancer, vitamin E serving as an antioxidant and a skin protectant, ethyl alcohol serving as a transdermal absorption penetration enhancer, natural essential oil serving as a transdermal absorption penetration enhancer, an antibacterial natural drug and essence. The submicroemulsion antifungal drug spray preparation has the advantages that the solubility and the uniformity of oil soluble antifungal drugs in water are increased, the transdermal absorption of the drugs is enhanced, the drugs are fed into dermis, and the absorption and utilization ratios of the drugs are increased, so that the effects of the antifungal drugs are increased; in the meantime, a cosolvent with side effects is avoided from being used, so that toxic and side effects caused by drugs entering whole body blood circulation systems and the stimulation to the skin are reduced, and the efficacies of protecting the skin and improving the looks are provided.

The invention discloses a method for directly oxidizing a benzyl-position C-H bond into ketone, wherein aryl ethyl compounds are catalyzed and oxidized by nitrite ester; a synergistic catalytic system of free radical initiator and nitrite ester is adopted, and a catalytic system of non-metallic catalyst and oxygen is adopted, the oxidization of the C-H bond of a free radical-activated aryl side chain is simple in operation; after completing the reaction, petroleum ether / ethyl acetate at a volume ratio of (50-1):1 is used as an eluent; column chromatography separation is performed to obtain a target product. The catalytic system in the invention uses oxygen as an oxygen source and has high atomic economy; the invention is a non-metallic catalytic system and provides a novel method for avoid metal residues in synthetic drugs; for diethyl aromatic hydrocarbon, the method provided by the invention can be adopted to selectively oxidize diethyl aromatic hydrocarbon into monoketone and diketone; the method of the invention can be adopted to efficiently synthesize tranquillizer lenperone, so that a novel method for synthesizing lenperone is provided.

The invention relates to a process of a chemical synthesis medicament, in particular to a novel synthesis process of erlotinib hydrochloride serving as an antitumor medicament, and a novel intermediate. The process has the advantages of low-price and readily-available raw materials, mild conditions in a reacting process, no device with special requirements and suitability for industrial production.

The invention describes antibodies that bind molecules of the pyrrolidinophenone class of synthetic drugs. The antibodies are derived from novel chemical intermediates, haptens and immunogens and are used in methods and kits to detect and quantify pyrrolidinophenones.

This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

The invention relates to the technical field of feed, in particular, to a compound plant extract feed additive and a preparation method thereof. The invention aims to provide a compound plant extract feed additive with a strong antibacterial effect for solving various defects such as existence of toxic and side effects caused by adding other synthetic drugs such as antibiotic in the feeds, and excellent effects are achieved. The technical scheme of the invention is to provide the compound plant extract feed additive, which comprises citrus essential oil, allicin, tangeritin, pine needle meal and pine flower essential oil. The compound plant extract feed additive has the following benefits: based on the traditional Chinese herbal medicine theoretical research and practice, 4 traditional Chinese herbal medicines and 5 extracts are chosen, the in-vitro antimicrobial activities thereof are measured, and plant extracts having restraining effect to aeromonas hydrophila are selected out to prepare compound preparation. The compound plant extract feed additive has the characteristics of excellent in-vitro antimicrobial activity, high efficiency, safety, no poison and no residue for long-time use.

The invention relates to a method for preparing pharmaceutical cocrystals through suspension crystallization. The method concretely comprises the following steps: firstly screening solid forms of active pharmaceutical ingredients API and cocrystal formation CCF in different solvents, preparing a CCF saturation solution together with a solvent which cannot generate solvate together with the API and CCF; feeding the prepared CCF saturation solution into a vessel type stirrer, feeding the solid API and CCF according to a certain solid load rate, and deciding the ratio of molar weight of the API and CCF according to the cocrysal chemical metrological ratio; and sampling to do XRD or DSC testing after fully stirring and mixing, so as to prove that the cocrystal solid phase is pure, performing vacuum filtration to the obtained solid, and washing and drying the CCF saturation solution to obtain a solid, namely a final cocrystal product. Compared with other methods, the method is low in energy consumption, less in used solvent, low in cost, simple in technology, easy to amplify, fast and easy to obtain, high in the purity of products, and suitable for industrial large-batch synthesized pharmaceutical cocrystals.

Disclosed is a novel synthetic method for isomeric peptides through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid. The novel synthetic method produces isomeric peptides of L-selenomethionine or Se-Methyl-L-selenocysteine that exhibit (i) enhanced water solubility; (ii) enhanced rate of dissolution in water; (iii) enhanced bioavailability; (iv) excellent vascular endothelial growth factor promoting activity; (v) excellent anti-5-alpha-reductase activity; (vi) capabilities to prevent / reduce “hair fall” and promote “hair growth”, thereby maintaining a perfect homeostasis for “hair care”. Cosmeceutical and pharmaceutical compositions comprising the isomeric peptides obtained through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid are also disclosed. Other dipeptides with several other amino acids and uses thereof are also disclosed.

The invention discloses sedative and hypnotic active saponin components of a spina date seed, as well as separation and purification method and application of the sedative and hypnotic active saponin components, and belongs to the field of separation of natural products. The invention designs a new and relatively safe extracting route without introducing obviously toxic solvents and agents. The separation and purification method is characterized by comprising the following steps of: extracting a spina date seed sedative and hypnotic active saponin sample from a spina date seed sample by the alcohol extraction method and n-butanol extraction method; and then separating spina date seed sedative and hypnotic active saponin components I and II from the saponin sample by the column chromatography and thin-layer chromatography. The two spina date seed saponin components separated from the spina date seed show obvious hypnotic activity; and the natural sedative and hypnotic active components extracted and separated from traditional Chinese medicine can be used for solving the problems of multiple side effects and addiction of chemical synthetic drugs and is beneficial to human health and contributed to all the society.

The invention discloses a traditional Chinese medicine compound feed for egg quails and a preparation method thereof and belongs to the field of quail feeds. The compound feed comprises the following components: 30-50 parts of extruded corn, 20-40 parts of fermented soybean meal, 10-15 parts of supper fish meal, 2-4 parts of soybean oil, 2-5 parts of grass seed powder, 2-3 parts of soybean oil cake, 5-7 parts of rice bran, 3-5 parts of table salt, 4-6 parts of premix and 0.5-1 part of traditional Chinese medicine additive. The preparation method comprises the following steps: (1) preparation of the premix; (2) extraction of a traditional Chinese medicine liquid; (3) refining of the traditional Chinese medicine liquid; (4) preparation of the traditional Chinese medicine additive; and (5) preparation of the traditional Chinese medicine compound feed. The feed disclosed by the invention has the advantages that the traditional Chinese medicine additive reasonable in formula is adopted, so that the egg laying rate of the egg quails is effectively increased and the death rate is reduced; no chemical synthetic drug such as antibiotic is contained in the feed, so that the additive entering the egg quail bodies is prevented from generating drug residue in quail eggs, the quality of the quail eggs is effectively kept and the quail eggs are healthy and safe to eat by people.

The invention discloses a traditional Chinese medicine composition used for detoxification and a preparation method thereof. In the traditional Chinese medicine composition, radix bupleuri plus dragon bones and oysters combination spina date seeds are taken as a core, so that other more than forty traditional Chinese medicines are compatible, the curative effect of a decoction is enhanced, the traditional Chinese medicine composition is guided to an action target of a synthetic drug having the damage to an organism, the efficacy accurately reaches a lesion, vivotoxin is eliminated, the organism is adjusted and restored, the adaptive capacity of the organism is improved, and the organism is enabled to be adaptive to the change of an internal environment in an efficiency action period, therefore, the original physiological equilibrium of the organism is adjusted and restored. The traditional Chinese medicine composition disclosed by the invention has the effects of strengthening the body resistance, resolving toxin, activating blood circulation, opening orifice, adjusting the physiological equilibrium of the organism and restoring functions of a nervous system. Therefore, the traditional Chinese medicine composition is suitable for realizing treatment and rehabilitation of dependence and withdrawal symptoms of a novel synthetic drug.

The invention discloses a feed for improving the quality and the flavor of pork. The feed contains a plurality of amino acid chelate microelements, vitamin, a plant extract and the like. The additive amount of organic microelements and inorganic microelements in the feed can be effectively reduced, the residual quantity of metal is reduced, the environmental pollution is alleviated and the ecological environment is protected. Meanwhile, the plant extract is reasonably matched, so that the carcass lean meat rate is significantly increased, the eye muscle area is increased, the carcass fat rate and backfat areim reduced, the flavor of the pork is improved, the quality of the pork is improved, the feed is capable of replacing antibiotics and a chemical synthetic drug feed additive to produce safe and excellent pork, and the problems that the pork is poor in quality, more in PSE meat and poor in flavor in current pig production are solved.

The invention belongs to the technical field of the organic synthetic chemistry and specifically relates to a simple and feasible method for synthesizing an imidazo[1,2-a]pyridine-3-formaldehyde compound through one step. The invention provides a method for synthesizing the imidazo[1,2-a]pyridine-3-formaldehyde compound through a [3+2] cyclization reaction of 2-aminopyridine and cinnamylaldehyde through one step; the method has the advantages that the raw materials are simple and easily available, the step is simple and efficient, multi-step synthesis of a reaction precursor is avoided, the reaction time is effectively shortened, the extended application range of the product is wide, and the like. In particular, due to the use of 2-aminopyridine / pyrazine, imidazo[1,2-a]pyridine / pyrazine derivatives can be synthesized through one step. The method provided by the invention is applicable to synthesizing various imidazo[1,2-a]pyridine compounds. Besides, the method is capable of effectively synthesizing drug molecules Alpidem and Zolipidem.

Disclosed is a method for producing exosomes having effects of skin regeneration and wound healing, comprising the steps of: providing ultrasonic stimulation directly or indirectly to cells; culturinga mixture of the cells and a medium for a predetermined amount of time; and separating exosomes from the mixture, wherein direct provision of stimulation is the application of ultrasonic stimulationto a medium comprising cells, and indirect provision of stimulation is the application of ultrasonic stimulation to a medium that does not comprise cells and then mixing the medium with the cells. Theexosome production method enables exosomes, having effects of skin regeneration and wound healing, to be obtained in a high yield and short amount of time by means of a simple process called sonication from stem cells, which are difficult to be handled, and also from somatic cells, which can be easily obtained and maintained. The exosomes obtained thereby also have a high amount and number of various included factors, the exosomes and compositions comprising same have increased various factors, which can induce skin regeneration and wound healing, and the exosomes have a phospholipid-based membrane structure so as to facilitate skin penetration and allow high efficiency of substance delivery, thereby enabling skin regeneration and wound healing to be effectively induced, and are safe andhave no side effects caused by the use of synthetic drugs.

This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II,or a salt thereof, and a compound of formula VIor a salt thereof, wherein R3 and R4 as well as Act are as defined in the specification, and processes of manufacturing these.Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.

This invention relates to an organic iodine complex, in which iodine serves as coordination center and functional group-containing organics serve as chelating reagent. The functional groups can be amino and / or hydroxyl and / or carboxyl, and the representatives of hydroxyl- and carboxyl-containing organics are 2-hydroxy-4-methylthiobutanoic acid and 2-hydroxypropanoic acid, respectively. This invention also relates to a combination of organic iodine complex and its application in pharmacy. The combination comprises 0.3~40% organic iodine complex as active ingredient and one or more ingredients chosen from the following ones: natural aminoacyl iodine, solvent, surfactant, food additives, food and synthesized drugs. This combination can be used in preparation of drug against AIDS, white spot syndrome virus in penaeid shrimp, Taura syndrome virus; grass carp hemorrhage virus, stomatitis, pharyngitis, colpitis, tumor, digestive tract diseases in poultry, histomoniasis, coccidiosis, human digestive tract diseases and iodine deficiency diseases.

The invention relates to a manufacturing method of a bamboo fence. The manufacturing method includes the following steps that (a) raw bamboos are subject to straightening cutting to obtain bamboo wood; (b) drying is carried out at the temperature ranging from 180 DEG C to 250 DEG C for 2 h to 3 h, and mould proof and insect prevention liquid is sprayed; cooling is carried out to 150 DEG C to 180 DEG C for 6 h to 10 h; and then mould proof and insect prevention liquid is sprayed, and cooling is carried out to 50 DEG C to 150 DEG C for 3 h to 6 h; (c) the fence is manufactured; (d) heat treatment is carried out for 3 h to 5 h under the conditions that the temperature is 120 DEG C to 200 DEG C and the pressure is 0.2 MPa; (e) water spray cooling is carried out; and (f) drying is carried out at 45 DEG C to 60 DEG C until the water content is 10% to 18%. According to the manufacturing method, the special mould proof and insect prevention liquid is adopted, and therefore the mould proof and insect prevention effect of the bamboo fence can be at least two years; and the mould proof and insect prevention liquid does not contain illegal synthetic drugs, and therefore bad effects on the environment and biology can be avoided. According to the manufacturing method, after bamboo wood heat treatment, nutrient substances in the bamboos are dissolved, and fungi inactivation is achieved. The color of the bamboos is changed from natural green to carbon black, and the colors of the bamboos with different ages and at different parts can trend to be the same.

The invention relates to an anti-diarrhea feed additive for piglets. The anti-diarrhea feed additive for the piglets comprises the following ingredients: 30-50 parts of a plant essence oil mixture, 10-30 parts of a traditional Chinese medicine named herba portulacae, 10-25 parts of fructo-oligosaccharides, 10-25 parts of manno-oligosaccharides, 5-15 parts of sodium butyrate, 5-15 parts of citric acid, 5-15 parts of fumaric acid, 20-50 parts of maltodextrin, 5-15 parts of silicon dioxide and 60-95 parts of a montmorillonite powder carrier; and the plant essence oil mixture is prepared by mixing and blending the following raw materials: 4-10 parts of common origanum oil, 2-8 parts of clove oil and 2-8 parts of cinnamon oil. Being added into piglet feeds, the feed additive is capable of effectively improving piglet immunity, enhancing disease resistance and disease prevention abilities of the piglets, improving anti-stress abilities, reducing diarrhea occurrence rates of the piglets, and improving growth performances; the feed additive is free of any toxic side effects, and is safe and reliable to use; moreover, the feed additive can be used to replace veterinary antibiotics and other chemical synthetic drugs which are commonly used at present.

The invention belongs to the field of drug preparation and particularly relates to a purification technology of a synthetic drug. The method comprises the steps of adding a methanol solvent and a dipyridamole crude product into methyl benzenesulfonic acid and 1-(3-aminobenzene)-3-methyl-2-imidazolone, stirring for reaction to form a sulfonate intermediate product, mixing the sulfonate intermediate product and a 70% methanol solution for dissolving, adding alkaline liquor to regulate pH (potential of hydrogen) of a system to 8-8.5, then adding active carbon, carrying out heating, decoloring, stirring and press filtration, cooling filtrate, and carrying out centrifuge, washing and drying to form purified high-purity dipyridamole.

The present invention relates to drug derivatives and linkers. The invention specifically relates to compounds and methods of phosphonates and linkers, that are useful as carriers for imaging agents and useful in the treatment of various bone diseases.

The invention belongs to the field of synthetic drugs, and relates to an application of geniposide in alleviating side effects of glucocorticoid, and an application of compounds represented by the formula I or pharmaceutically acceptable salts, esters, or prodrugs in preparation of drugs for alleviating side effects of glucocorticoid. The molecular action mechanism of the compounds in alleviatingthe side effects of glucocorticoid drugs has important clinical significance for developing new drugs.

The invention discloses a gait balance training and testing device for improving a cognitive function of a synthetic drug addict. The device comprises a testing unit, a data conversion and output unit and a computer, wherein the testing unit comprises a physical footpath and a plurality of gait information detectors; a pedal surface is arranged on the physical footpath; the gait information detectors are arranged on the two sides of the walking direction of the physical footpath, and are connected with the data conversion and output unit; the data conversion and output unit is connected with the computer. According to the technical scheme, the gait information detectors are arranged on the two sides below the footpath on which a tested person walks, and are used for recording information about the falling of feet of the tested person off the footpath detection and evaluation when the tested person walks abnormally; when the device is applied to synthetic drug addict inpatients and outpatients of various drug addiction treatment institutions, the cognitive function of the synthetic drug addict can be effectively improved, and the device is significant for lowering the relapse rate and shortening the rehabilitation course.