50 results about "Synthetic drug" patented technology

The invention provides a system and method utilizing, among other things, fluorescence spectroscopy in the ultraviolet portion of the electromagnetic spectrum to determine chemical species and concentrations. The basic measuring system includes optics, a spectrograph, a detector, and an energy source (“head” components), along with a computer and control electronics and power source capable of generating and detecting unique fluorescence signatures for individual and unique mixtures of chemical substances including, for example, prescribed and / or compounded medications, alcohol products, food types, synthetic drugs, narcotics, perfumes, liquids, and the like.

A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are alpha1-antitrypsin and synthetic drugs mimicking some or all of the actions of alpha1-antitrypsin.

A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are alpha1-antitrypsin and synthetic drugs mimicking some or all of the actions of alpha1-antitrypsin.

The invention relates to a submicroemulsion antifungal drug spray preparation. The preparation mainly comprises the following components: an antifungal chemical synthetic drug, lecithin serving as an emulsifier, a transdermal absorption penetration enhancer and a skin protectant, soybean oil or other essential oils serving as an oil soluble diluent, glycerin serving as an isoosmotic adjusting agent, oleic acid serving as a co-emulsifier and a transdermal absorption penetration enhancer, azone serving as a transdermal absorption penetration enhancer, vitamin E serving as an antioxidant and a skin protectant, ethyl alcohol serving as a transdermal absorption penetration enhancer, natural essential oil serving as a transdermal absorption penetration enhancer, an antibacterial natural drug and essence. The submicroemulsion antifungal drug spray preparation has the advantages that the solubility and the uniformity of oil soluble antifungal drugs in water are increased, the transdermal absorption of the drugs is enhanced, the drugs are fed into dermis, and the absorption and utilization ratios of the drugs are increased, so that the effects of the antifungal drugs are increased; in the meantime, a cosolvent with side effects is avoided from being used, so that toxic and side effects caused by drugs entering whole body blood circulation systems and the stimulation to the skin are reduced, and the efficacies of protecting the skin and improving the looks are provided.

The invention discloses sedative and hypnotic active saponin components of a spina date seed, as well as separation and purification method and application of the sedative and hypnotic active saponin components, and belongs to the field of separation of natural products. The invention designs a new and relatively safe extracting route without introducing obviously toxic solvents and agents. The separation and purification method is characterized by comprising the following steps of: extracting a spina date seed sedative and hypnotic active saponin sample from a spina date seed sample by the alcohol extraction method and n-butanol extraction method; and then separating spina date seed sedative and hypnotic active saponin components I and II from the saponin sample by the column chromatography and thin-layer chromatography. The two spina date seed saponin components separated from the spina date seed show obvious hypnotic activity; and the natural sedative and hypnotic active components extracted and separated from traditional Chinese medicine can be used for solving the problems of multiple side effects and addiction of chemical synthetic drugs and is beneficial to human health and contributed to all the society.

The invention discloses a preparing method by using unactivated olefin hydrogen trifluoride methylation and application thereof. The method comprises the following steps: A, adding unactivated olefin I, sodium trifluoromethanesulfonate and a photocatalystIr[dF(CF3)ppy]2(dtbpy)PF6 into a Schlenk tube; B, vacuumizing, replacing argon, adding methyl alcohol; C, irradiating the Schlenk tube with a fluorescent lamp, and stirring to react; and D, after reaction is finished, adding water into the system to perform a quenching reaction, extracting with ethyl acetate, separating an organic phase, drying, filtering, performing rotary evaporation to remove a solvent, chromatographing the residue through an ethyl acetate / petroleum ether mixed solvent to obtain a target product II, wherein the proportion of the ethyl acetate / petroleum ether mixed solvent is selected according to different polarities of the product, and silica gel is adopted as a solid phase in column chromatography. The method applied to medicinal molecule synthesis is feasible, is simple and convenient to operate, and is used for implementing an unactivated olefin hydrogen trifluoride methylation reaction to prepare a series of trifluoromethyl-containing target compounds by selecting low-price trifluoromethyl reagent under a mild condition.

The invention relates to the technical field of feed, in particular, to a compound plant extract feed additive and a preparation method thereof. The invention aims to provide a compound plant extract feed additive with a strong antibacterial effect for solving various defects such as existence of toxic and side effects caused by adding other synthetic drugs such as antibiotic in the feeds, and excellent effects are achieved. The technical scheme of the invention is to provide the compound plant extract feed additive, which comprises citrus essential oil, allicin, tangeritin, pine needle meal and pine flower essential oil. The compound plant extract feed additive has the following benefits: based on the traditional Chinese herbal medicine theoretical research and practice, 4 traditional Chinese herbal medicines and 5 extracts are chosen, the in-vitro antimicrobial activities thereof are measured, and plant extracts having restraining effect to aeromonas hydrophila are selected out to prepare compound preparation. The compound plant extract feed additive has the characteristics of excellent in-vitro antimicrobial activity, high efficiency, safety, no poison and no residue for long-time use.

An inflammation-relieving and antibacterial exterior-applied synthetic medicine is prepared from quinolone and amino acid through reaction. A soluble staltic gauze for treating wound is prepared through adding quinolone and amino acid to water or aqueous solution of alcohol, regulating concentration to 5-30 wt.%, reacting for 0.5-30 hr, mixing the resultant with soluble fibres in alcohol solution for 0.5-30 hr, and drying the soluble fibres. Said gauze can be filled in wound or used to cover on wound to promote healing of wound without secondary pollution.

The invention discloses a feed formula for sows. According to the formula, feed is mainly prepared from following raw materials in parts by weight through crushing and even mixing: 50-60 parts of corn flour, 40-50 parts of soybean meal, 20-25 parts of peanut meal, 20-24 parts of bran, 15-20 parts of wheat middling, 10-15 parts of corn gluten meal, 3-5 parts of fish meal, 1-3 parts of table salt, 15-16 parts of soybean oil, 4-5 parts of donkey-hide gelatin, 1-1.4 parts of lysine, 1.5-2 parts of baking soda, 1-1.5 parts of methionine, 1-1.2 parts of choline chloride, 0.8-1.2 parts of yeast, 2-4 parts of multivitamins and 10-12 parts of a traditional Chinese medicine additive. The feed for the sows is reasonable in ratio, rich in nutrition and good in palatability, multiple Chinese herbal medicines are added, the meat quality of animals is improved, the disease resistance is enhanced, the immunity of the animals can be significantly improved, the death and culling rate is decreased, feed absorption is accelerated, reproductive performance of the sows is effectively improved, the number of live births is increased, and the economic benefit is increased; the feed contains no antibiotics and chemical synthetic drugs and is high in safety.

The invention relates to a method and a sensor for detecting on-site damage of nucleic acid in photo-electrochemistry, and provides a method for detecting gene toxicity of chemical substances simply, quickly and sensitively. The method comprises the following steps: (a) an analyte possibly having gene toxicity is contacted with the nucleic acid; (b) if the analyte to be detected expresses the gene toxicity after being activated, a corresponding enzyme is used as an activating agent; (c) photo-electrochemical active molecules are used as a signal indicator; and (d) the combination and / or reaction between the analyte and the nucleic acid is elevated, that is, in the presence of electrodes, current generated by electron transfer between the photoelectrical signal molecules and the electrodes under the action of light is evaluated, and qualitative analysis or quantitative analysis for the gene toxicity of the analyte is carried out according to the difference of photocurrent response before and after the nucleic acid contacts with the analyte. The method and the sensor are applied in the fields of toxicity screening for industrial chemicals, toxicity detecting for environmental pollutants, toxicity testing for synthetic drugs, environmental toxicology research, and the like.

The invention belongs to the field of synthetic drugs, and relates to an application of geniposide in alleviating side effects of glucocorticoid, and an application of compounds represented by the formula I or pharmaceutically acceptable salts, esters, or prodrugs in preparation of drugs for alleviating side effects of glucocorticoid. The molecular action mechanism of the compounds in alleviatingthe side effects of glucocorticoid drugs has important clinical significance for developing new drugs.

The invention discloses a synthetic method for preparing a water-soluble targeting antitumor drug; the anticancer synthetic drug prepared by using the synthetic method has stable chemical properties. The synthesis in the method includes one-step reaction of DHA (docosahexaenoic acid) in site 2' of docetaxel. The method includes: mixing docetaxel, 4-dimethylaminopyridine, 1,3-dicyclohexylcarbodiimide and DHA, dissolving the mixture in dichloromethane, and stirring at room temperature for reacting; after reacting, diluting, washing, drying, and isolating by means of column chromatography to obtain the drug. After the preparation of the targeting anticancer drug, the water solubility of the anticancer drug docetaxel can be enhanced; as docosahexaenoic acid has targeting property, the anticancer action of the docosahexaenoic acid can be enhanced significantly.

This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

The invention discloses a synthesis method of a chiral 3,4-dihydrocoumarin derivative compound. The method specifically comprises steps as follows: 2-hydroxychalcone and azlactone are taken as reactants, and a product is synthesized in a solvent under the catalysis of multifunctional chiral quinine thiourea. According to the method, raw materials are simple and easy to obtain, reaction conditions are mild, post-treatment is simple and convenient, the applicable substrate range is wide, the yield is high, and the enantioselectivity is high; the synthesized product can be used for synthesizing intermediates of drugs and insecticides.

The invention relates to a synthetic drug genotoxic impurity analysis method based on solid phase microextraction. The solid-phase microextraction fiber comprises covalent organic framework nano microspheres and a fiber carrier, wherein the covalent organic framework nano microspheres are loaded on the surface of the fiber carrier; wherein the covalent organic framework nano microsphere is formedby combining two ligands tri-(4-aminophenyl)-amine and tri-(4-formylphenyl)-amine. The determination of the genotoxic impurities in the raw material medicine is achieved. The solid-phase microextraction fiber has the characteristics of high temperature resistance, high repeated use frequency and high adsorption capacity.

The invention discloses a method for preparing a benzylated quinoxalinone compound under visible light catalysis. The benzylated quinoxalinone compound is synthesized under the irradiation of visible light by taking a quinoxalinone compound and benzyl bromide as raw materials, xanthate as a catalyst and sodium acetate (NaOAc) as an additive. The method has the advantages of mild reaction conditions, simplicity and convenience in operation, no oxidant, wide substrate application range and the like. The compound has potential application value in the research fields of medicine, organic synthesis and the like, can be used for synthesizing a drug molecule, namely an aldose reductase inhibitor and a structural molecule with anti-depression activity, and provides a new preparation method for synthesis of benzylquinoxalinone compounds.

The invention provides an aromatic phenolic compound for room-temperature phosphorescence detection of drug gas and a sensing film and application thereof. The aromatic phenolic compound has a structure as shown in a formula I. Organic matter in the film comprises a conjugated aromatic macrocyclic compound containing a phenolic hydroxyl group, meanwhile, an aromatic ring further comprises an electron-withdrawing substituent group, a proper solvent is selected to prepare a solution, then the sensing film is prepared through dispensing, dip-coating or spin-coating and other methods, the film can sense drug gas. Research finds that the sensed film has room temperature phosphorescence, so that the sensing process can be monitored by monitoring the change of the intensity of the room temperature phosphorescence, and room temperature phosphorescence sensing has the advantages of high sensitivity, high selectivity, high response speed and strong anti-interference capability; according to the aromatic phenolic sensing film provided by the invention, room-temperature phosphorescent efficient detection of synthetic drugs represented by methamphetamine can be realized, and the aromatic phenolic sensing film is expected to be applied to drug enforcement work of public security departments in the future.

The invention relates to drug toothpaste for treating oral diseases and a preparation method thereof. The drug toothpaste is new type toothpaste adopting Chinese medicines including paeonol, and the like as main drug-effect ingredients and serving with anti-allergic and anti-hemostatic drug-effect ingredients. Compared with other chemical synthetic drugs, the drug toothpaste has the characteristics of small irritation and small toxic and side effects. The drug toothpaste has the functions for treating oral diseases, such as dental arthritis, toothache, hemodia, and the like. With long-term use, the drug toothpaste can improve oral environment and maintains oral health. The drug toothpaste has the advantages of reasonable formula, simple process and significant effect.

The invention relates to a preparation method and application of dracocephalum heterophyllum benth volatile oil. Compared with existing antiviral synthetic drugs, the dracocephalum heterophyllum benth volatile oil has low toxicity and strong drug action and is safe and reliable. Moreover, the dracocephalum heterophyllum benth raw material is rich and cheap, is simple in extraction process and low in preparation cost and can be prepared into various dosage forms.

The invention discloses a traditional Chinese medicine for radically curing hemorrhoids, and the traditional Chinese medicine is prepared by the following components by weight percentage: 4-7g of sanchi, 9-12g of common cephalanoplos herb, 70-90g of lalang grass rhizome and 12-17g of garden burnet root; the traditional Chinese medicine is prepared by adopting purely natural Chinese herbal medicines and has no chemical synthetic drugs, simple formula, low cost and no toxicity or side effects, the various components have the mutual cooperation and action, the traditional Chinese medicine can carry out the deep conditioning and directly achieve an intestinal focus, thereby having the advantages of rapidly clearing heat, relieving swelling, promoting granulation, relieving pain, repairing intestine and anus, improving hematochezia symptom and having rapid onset of action and short treatment course; the hemorrhoids can be thoroughly cured and eradicated by taking the traditional Chinese medicine for six days, and patients have no recurrence, thereby relieving the lifelong suffering of the patients.

The invention belongs to the technical field of one critical step in microwave nitrile hydrolysis and demethylation hydrolysis of chemical synthesis medicine methyldopa [alpha-methyl-(3,4-dyhydroxy phenyl)-alpha-aminopropionic acid, similarly hereinafter] or synthetic chiral medicine L-methyldopa [L-alpha-methyl-(3,4-dyhydroxy phenyl)-alpha-aminopropionic acid, similarly hereinafter], i.e. the chemical reaction for preparing methyldopa or L-methyldopa from alpha-methyl-(3,4-dimethoxy phenyl)-alpha-aminopropionitrile or L-alpha-methyl-(3,4-dimethoxy phenyl)-alpha-aminopropionitrile through microwave nitrile hydrolysis and demethylation hydrolysis. The microwave hydrolysis uses low-concentration hydrochloric acid or hydrobromic acid, so the energy sources and the economic cost are reduced, the acid wastewater discharge is reduced, by-products are reduced, and the purity and the yield of products are improved.

The invention discloses a preparation method of a 2-trifluoromethyl substituted quinazolinone compound. The preparation method comprises the following steps: adding a palladium catalyst, a ligand, a carbon monoxide substitute, an additive, trifluoroethylimido acyl chloride and amine into an organic solvent, reacting at 110 DEG C for 16-30 hours, and after the reaction is completed, carrying out post-treatment to obtain the 2-trifluoromethyl substituted quinazolinone compound. The preparation method has the advantages of simple operation, cheap and easily available initial raw materials, high reaction efficiency, good substrate compatibility, synthesis of trifluoromethyl quinazolinone compounds substituted by different groups through substrate design, convenient operation, and broadening of the practicality of the method. The method is also successfully applied to the high-yield synthesis of the drug molecule Rutaecarpine.

The invention discloses a synthesis method and application of novel fluorine-containing oxime ethers, belonging to the technical field of organic synthesis. The structural formula of the novel fluorine-containing oxime ether is one selected from the group consisting of formulas I to V. The formulas are as described in the specification. In the structural formulas, R is 2-Naphth or NHBoc, and Y isO or NBoc. Five fluorine-containing oxime ethers with new structures are provided in the invention, and due to the strong electron withdrawing capacity of -C5F4N, an N-O bond is particularly easy to crack uniformly under a heating or photocatalysis condition and can further participate in a free-radical relay reaction. A fluorine-containing oxime ether participated activated C-H bond free radicalreaction formed in the invention replaces traditional transition metal catalytic activation, and the reaction is a simple and environment-friendly manner for drug synthesis and natural product modification and has a high yield of up to 90%.

Black fungus polysaccharide composite weight-reducing congee powder and a preparation method thereof relate to a weight-reducing product and a preparation method thereof. According to the invention, natural plant extracts are used as main materials, and the problem that common weight-reducing products contain chemical synthetic drugs, are often accompanied with side effects, have half lives, are transient, and can not effectively act on patients for a long time is solved. The congee powder comprises the following components by mass: 40%-50% of black fungus polysaccharide, 2%-10% of konjak powder, 15%-25% of tartary buckwheat powder, and 25%-35% of xylitol. The preparation method comprises: drying and crushing black fungus to extract polysaccharide, and mixing the polysaccharide with konjak and tartary buckwheat powder to obtain the black fungus polysaccharide composite weight-reducing congee powder. The black fungus polysaccharide composite weight-reducing congee powder is a natural composite weight-reducing product, has no side effect on human body, has good weight-reducing effect, and is suitable for eating by various populations.

The invention relates to a Prunus padus L. anthocyanin-containing health product for preventing Alzheimer's disease. The health product comprises the following ingredients, by weight, 30-50% of Prunus padus L. anthocyanin, 10-30% of Prunus padus L. polysaccharide, 5-15% of sorghum rice polypeptide, 5-15% of Chinese chestnut polypeptide, 5-10% of a Chinese yam extract product, 5-10% of a Poria cocos extract product, 5-10% of a Ligusticum wallichii extract product and 5-10% of a dwarf lilyturf root extract product. Through in vitro experiment and animal experimental research on the product's function of preventing Alzheimer's disease, it is found that the health product has activity and function for preventing Alzheimer's disease and can replace chemical synthetic drugs so as to avoid toxic and side effect caused by excessive chemical synthetic drugs. Thus, a Prunus padus L. anthocyanin composition has a wider development prospect and can become a newly-developing component applied in health products.

The invention belongs to the technical field of traditional Chinese medicines and discloses a medicine for treating urinary system damage diseases caused by synthetic drug ketamine dependence. The medicine mainly comprises, by weight, 28-32 parts of Lygodium japonicum, 28-32 parts of lalang grass rhizome, 10-14 parts of sargentgloryvine stem, 23-27 parts of prepared rehmannia root, 10-14 parts ofChinese yam, 7-8 parts of rhizoma alismatis, 13-17 parts of giant knot weed, 10-14 parts of pulp of dogwood fruit, 8-12 parts of ligusticum wallichii, 8-10 parts of moutan bark, 8-10 parts of poria cocos and 13-17 parts of dandelion. The invention also discloses a preparation method and use of the medicine. The medicine has the remarkable curative effect on the symptoms of lower urinary tract injury caused by ketamine abuse, quickly relieves urinary tract irritation symptoms such as odynuria, urgent urination, frequent micturition and hematuresis and reduces the use of antibiotics and hormones.

The invention relates to a traditional Chinese medicinal composition for promoting growth and development. The traditional Chinese medicinal composition is prepared from poria, the root of Mongolian milkvetch, Chinese yams and the rhizome of largehead atractylodes. The traditional Chinese medicinal composition has the effects of tonifying the spleen and qi and nourishing the stomach, and can promote growth and development and improve production performance. Compared with antibiotics, hormones and chemically synthetic drugs, the traditional Chinese medicinal composition has the advantages thatdrug residues in the body can be prevented, no toxic and side effects are caused, and safety and reliability are achieved.

Novel compositions and methods of treating and preventing a viral infection are provided. A method of blocking a viral infection facilitated by a serine proteolytic (SP) activity is disclosed, which involves administering to a subject suffering or about to suffer from a viral infection a therapeutically effective amount of a substance having serine protease inhibitory activity or serpin activity. Among the substances found to be useful are α1-antitrypsin (AAT), peptide derivatives from the carboxy terminal end of AAT and synthetic drugs mimicking the action of such substances. The invention is particularly well suited for checking a viral infection mediated by members of herpesviridae family.