288results about How to "Mild method conditions" patented technology

The invention discloses a magnetic gold nanoparticle composite material, and a preparation method and application thereof. The preparation method comprises the following steps: synthesizing ferroferric oxide magnetic microspheres, adding tetraethoxyl silicon to implement hydrolysis and polymerization on the magnetic microsphere surfaces, adding N-(2-aminoethyl)-3-aminopropyltrimethoxysilane to obtain surface-modified double-amino-group Fe3O4/SiO2 magnetic microspheres, and compounding the surface-modified double-amino-group magnetic microspheres with gold nanoparticles. The chelation action of the double amino groups is utilized to adsorb the gold nanoparticles more firmly; and the material combines the surface selectivity of the gold nanoparticles and the superparamagnetism of the magnetic nanoparticles, can extract benzopyrene in water, and can implement quick and efficient separation.

This invention relates to preparation method of a flakiness microcrystalline cellulose, as well as its surface reshaping method. The process: in water disperse medium, take reaction with sulfuric acid to gain flakiness microcrystalline cellulose, then surface by acetic acid esterification or SAA absorption modifing, repass wash, filter , dryness, gain the product. The mass ratio of water and cellulose is 3 to 25:1, sulfuric acid volumetric concentration for 30 to 80%, temperature for 10 - to 85 deg, time for 5 to 120 minutes. The mass ratio of acetic ester modifier or SAA and microcrystalline cellulose is 0.1 to 5: 100. The modifier not only keep the favorable physics and mechanical property of cellulose, but also improve dispersibility, greatly advance consistency with high molecular material, broaden the application area.

The invention discloses a preparation method of porosity electrospun fiber, suspending nano salt uniformly into polymer solution and proceeding electrospinning to obtain polymer/nano salt composite electrospun fiber, then using elution solution of the nano salt to proceed salt out, removing the nano salt and producing holes to obtain the porosity electrospun fiber. The method is provided with simple operation, low cost and less environmental pollution which is suitable for industrial production; the obtained porosity electrospun fiber has good shape, and can change pore diameter and surface roughness of electrospun fiber conveniently by changing particle diameter and dosage of nano salt, which can be used for preparing medicine molecular vehicle, tissue engineering stand, tissue repair replacement etc. The invention has wide application foreground.

The invention discloses application of a PEI modified carbon dot-FITC compound as a rate fluorescent pH probe and a Cu2+ fluorescent probe. Cherry tomatoes are used as raw materials, carbon dots with fluorescence insensitive to pH changes are prepared through hydro-thermal synthesis, then CDs are modified with PEI, amidogen on PEI react with isothiocyanic acid radicals on FITC molecules, and the compound is formed. The responsivity of fluorescence of FITC in the compound to the pH changes is high, and a rate probe based on CDs and FITC fluorescence is used for pH detection; amidogen on PEI and Cu2+ are subjected to coordination, so that the fluorescence intensity of CDs and FITC is reduced along with increase of the concentration of Cu2+ in a solution, and Cu2+ detection is achieved. According to the constructed fluorescent probe, selected materials are novel, the advantages of being high in sensitivity, good in selectivity, easy to operate, wide in linear range, low in detecting limit and the like are achieved, and the constructed fluorescent probe can be used for efficient detection of the pH and Cu2+ in the aqueous solution and a biological sample.

The invention discloses a novel synthetic method for 3-formyl-imidazole[1,2-a]pyridine and 2-butyl-5-chloro-1H-imidazole-4-carboxaldehyde, and effective application of the method into synthesis of Necopidem and Saripidem. According to the invention, a 3-formyl-imidazole[1,2-a]pyridine system is established by using a cheap and low toxic Cu-catalyed O2 activated intramolecular olefin under dehydrogenation ammoxidation; conditions for the method are mild, reaction substrates are easily available, a catalytic system is simple, operation is simple, tolerance of functional groups is good, and the method is economical and effective and has very important scientific values and realistic significance.

The invention discloses a method for preparing a dental prosthetic material. The method comprises the following steps: 1) an enamel is soaked with a phosphoric acid solution or a blend solution of hydrogen peroxide and phosphoric acid for treatment; and 2) the enamel in the step 1) is laid in an HEDTA-Ca-P solution, and a fluorine ion solution is added into the HEDTA-Ca-P solution so that the enamel covered with the prosthetic material is obtained after the reaction. The method for preparing the dental prosthetic material is characterized in that the conditions are mild, the process is simple, the raw materials are cheap, the method has the clinical application value, the prior dental prosthetic material prepared is hopefully replaced by the dental prosthetic material prepared to repair dental caries or enamel damage caused by other dental diseases, and the dental prosthetic material can be also as taken as a pit and fissure sealant material used for preventing dental caries.

The invention discloses a method for catalyzing, oxidizing and degrading 2-chloroethyl ethyl sulfide through multi-niobium-vanadium-oxygen clusters and belongs to the field of catalytic chemistry. The method includes the steps that the 2-chloroethyl ethyl sulfide, a vanadium-cap type multi-niobium-vanadium-oxygen cluster catalyzing agent or a mixed multi-niobium-vanadium-oxygen cluster catalyzing agent and absolute methanol are added to a reaction vessel to be fully dissolved, a H2O2 aqueous solution is added dropwise, a reaction is conducted for a period of time under the stirring condition, and catalyzing, oxidizing and degrading of the 2-chloroethyl ethyl sulfide are completed. The conversion efficiency and product selectivity of the 2-chloroethyl ethyl sulfide are high, and the used multi-niobium-vanadium-oxygen cluster catalyzing agent can be used continuously; and furthermore, the conditions in the method are gentle, and the reaction can be conducted at the normal temperature under the normal pressure.

The invention discloses a method for biologically leaching heavy metal from a heavy metal-contained waste based on pH and potential co-regulation. The method comprises the following steps: in a process of leaching out the heavy metal-contained waste by an acidophilic iron oxide microbial agent, the pH value of the leaching system is controlled within 1.0-4.0 in the whole process; meanwhile, an oxidizing agent is combined with a reducing agent to regulate the redox potential of the leaching system, so that the redox potential of the leaching system is controlled within 420-650 mV; the pH value of the leaching system is gradually increased phase by phase in the leaching process; the redox potential of the leaching system is gradually increased phase by phase; the total leaching time is within 8 hours; and finally, the efficient leaching of the heavy metal from the heavy metal-contained waste by the acidophilic iron oxide microbial agent is realized. The method can accelerate biologic leaching of metal from sludge to shorten the leaching time and to reduce the acid consumption, and can greatly improve the biologic leaching efficiency.

The invention discloses a metal base ionic liquid catalyst and a method for degrading polyethylene glycol terephthalate by using the same, relating to an ionic liquid catalyst and a method for degrading polyester materials. The invention solves the technical problems that the existing ionic liquid catalysts for degrading PET have large dosage and long reaction time. The metal base ionic liquid catalyst is a combination of one or several of the followings. The method comprises the following steps: weighing raw materials and adding in a reactor, heating up to 90-210 DEG C and stirring for 0.5-5 h to complete the degradation of polyethylene glycol terephthalate. The method has the advantages of mild reaction conditions, small catalyst dosage, quick reaction speed, easy recovery, and no secondary pollution, wherein the PET conversion rate reaches 60-100 % in 0.5-5 h, and the monomer yield reaches 20-90 %. The invention can be used for degradation and reclamation of waste polyethylene glycol terephthalate.

The invention provides micro-nano particles; the micro-nano particles are vanadium pentoxide micro-nano particles and are formed by self assembly of nano sheets. The invention also provides a preparation method of the micro-nano particles, wherein the method comprises the following steps: 1) adding vanadium pentoxide to ethylene glycol, stirring to mix evenly, and forming a suspension A; 2) adding a sodium bicarbonate solution to the suspension A to form a suspension B; 3) heating the suspension B, and then standing and cooling at room temperature, to obtain a precursor containing a black precipitate; 4) carrying out centrifugal separation of the mixed solution containing the precursor and formed in the step 3), washing, and drying, to obtain a flower-shaped vanadium oxide precursor formed by nanosheet self-assembling; and 5) calcining the precursor obtained in the step 4) in an air atmosphere to obtain the micro-nano particles. The invention also provides an application of the micro-nano particles in the fields of new energy resources, environmental detection, food and medicines.

The invention discloses preparation and application of an Mxene-Mn3(PO4)2 composite electrode material. The preparation is characterized in that two-dimensional Ti3C2 nanosheets are synthesized from aTi3AlC2 ceramic material as a raw material, and ATP (adenosine triphosphate) is used as a template to induce synthesis of Mn3(PO4)2 nanoparticles. The Ti3C2/Mn3(PO4)2 nanocomposite synthesized with the method integrates good conductivity of Ti3C2 and biological mimetic enzyme activity of Mn3(PO4)2, and the composite material has excellent conductivity and catalytic performance by complementary advantages of the two raw materials, and is the excellent electrode material for preparing superoxide dismutase. The composite material can be used for constructing biosensors and has excellent application prospects in the fields of medical diagnosis, medical research and the like.

The invention discloses a preparation method of timosaponin A III. The method is used for preparing timosaponin A III by using commercially-available traditional Chinese medicine rhizoma anemarrhenae decoction slices or freshly collected rhizoma anemarrhenae roots and stems or fibrous roots as materials through a combined process of alcohol extraction, enzymolysis, extraction, resin and silicagel column chromatography, and crystallization. The purity of timosaponin A III prepared by the method disclosed by the invention is higher than 90%, therefore, the preparation method is suitable for largely preparing timosaponin A III.

The invention relates to a milk fermented product filtrate as well as a preparation method and application thereof. The milk fermented product filtrate comprises active ingredients extracted after fermentation of a milk culture medium and probiotics, wherein the probiotics is a mixture of lactobacillus and bifidobacterium; and the dosage of the probiotics is 40-80g per ton. According to the invention, water and milk are proportionally mixed according to proportion to obtain the milk culture medium, then the probiotics is added into the milk culture medium for fermentation in specific conditions, and finally, the fermented product is treated to obtain the milk fermentation product filtrate. Without any chemical component, the milk fermented product filtrate can be directly used as cosmetics such as mask, essence and toner while causing zero load on skin; and moreover, the fermented ingredient contains micro-molecule polypeptide which is easily sufficiently absorbed by skin. In the invention, by adopting edible probiotics for fermentation, the milk fermented product filtrate is beneficial to skin health and avoids the pollution of enzymes, chemicals and the like; and moreover, the conditions are mild, the operation is easy, the production steps are simplified, the production cost is lowered, and industrial production is facilitated.

The invention discloses a magnetic composite microsphere as well as a preparation method and an application thereof. The magnetic composite microsphere has an autologous active epoxy group with the content ranging from 0.1 mmol/g to 2.0 mmol/g, the diameter of the magnetic composite microsphere ranges from 50 nm to 150 nm, the magnetic composite microsphere is regularized, Fe3O4 nano particles are packaged in a network structure of a polymer, the content of Fe3O4 in the microsphere accounts for 20%-70%, and the specific saturation magnetization ranges from 20 emu/g to 60 emu/g. Simultaneously, the preparation method of the magnetic composite microsphere is provided, the method is mild in condition, convenient to operate and simple in device; and the prepared magnetic composite microsphere can covalently bind biomolecules through the autologous active epoxy group, can rapidly settle under the action of a magnetic field, and has high separation efficiency, low cost, simple process and industrialized application value.

The invention belongs to the field of an oligosaccharide preparation method, and particularly relates to a method for preparing chitosan oligosaccharide by adopting cellulase spray-drying. The methodfor preparing the cellulase spray-drying comprises the following steps: dissolving a chitosan in an acetic acid-sodium acetate buffering solution, preparing a chitosan solution, adding a cellulase solution into the chitosan solution to perform enzymolysis, after the enzymolysis, dialyzing filtrate by adopting a dialysis method, concentrating a dialysis solution, and spray-drying. The method for preparing the chitosan oligosaccharide by adopting the cellulase spray-drying is mild in condition, simple, rapid, short in preparation time, low in price of cellulase, easy in obtaining the cellulase and low in production cost, and the prepared chitosan oligosaccharide is uniform in molecular weight distribution and uniform and consistent in color.

A method for changing solidifying crucible bottom layering manner in electron beam polycrystalline silicon purification belongs to the field of electron-beam melting and comprises the following steps: layering 3 Kg of polycrystalline silicon wafers (with thickness of 7-10 mm) at the bottom of a solidifying crucible, and layering 5 Kg of polycrystalline silicon fragments on the polycrystalline silicon wafers; preheating electron guns; gradually increasing the power of an electron gun for irradiating a smelting crucible to 250 KW and the power of an electron gun for irradiating the solidifying crucible to 50 KW, and melting silicon; increasing the power of the electron gun for irradiating the solidifying crucible to 200 KW, and melting silicon; turning off the electron gun for irradiating the smelting crucible, outpouring silicon liquid, and increasing the power of the electron gun for irradiating the solidifying crucible to 250 KW; increasing the power of the electron gun for irradiating the smelting crucible to 250 KW, and melting and smelting silicon; and turning off the electron gun for irradiating the smelting crucible, outpouring silicon liquid, turning on the electron gun, keeping the power at 250 KW for 10 min, keeping the power at 200 KW for 2 min, keeping the power at 150 KW for 3 min, keeping the power at 120 KW for 5 min, keeping the power at 100 KW for 7 min, keeping the power at 80 KW for 8 min, keeping the power at 50 KW for 12 min, keeping the power at 30 KW for 16 min, keeping the power at 20 KW for 20 min, decreasing the power to 0 KW, and reducing the electron beam for solidifying. The method disclosed by the invention can increase product yield, and reduce the energy consumption of electron beam polycrystalline silicon purification.

The invention discloses a surface hydrophilization modification method of a polyvinylidene fluoride hollow fiber membrane, belongs to the field of materials, and discloses a method for performing hydrophilic modification on the surface of the polyvinylidene fluoride hollow fiber membrane by using an efficient click chemistry method. A hydrophilic group is introduced into the surface of the membrane to improve the anti-fouling performance of the surface of the membrane. The method is mild in condition and simple, and the process is easy to control. The method comprises the following specific steps: firstly, treating the membrane with strong alkali to generate an elimination reaction to remove a C-F bond, thus forming C=C double bonds; and then anchoring the hydrophilic group of a sulfhydrylcompound to the surface of the membrane by using the S-H bond and C=C double bonds in the sulfhydryl compound in an ultraviolet environment and under the action of a photoinitiator. The polyvinylidene fluoride membrane is low in surface energy and cannot form a hydrogen bond with water molecules; after the hydrophilic group is introduced into the surface of the membrane, the hydrophilicity and the pollution tolerance of the membrane are substantially improved.

The invention discloses a method for reducing carbonyl into methylene at normal temperature and normal pressure. The method includes the following steps that a carbonyl compound, a nitrogen doped carbon material loaded palladium catalyst and a solvent are added into a reaction container, the ratio of the carbonyl compound to the nitrogen doped carbon material loaded palladium catalyst is (1-5) mol:(10-40) g, hydrogen is introduced, reacting is carried out for 0.5-20 h at normal temperature and normal pressure, and carbonyl can be reduced into methylene through catalytic hydrogenation. The reaction formula of the reaction is shown in the specification. The method is simple, easy to operate, mild in condition, high in conversion rate, good in selectivity, low in cost and free of pollution to the environment.

The invention belongs to the technical field of metal organic skeletal material, and discloses a hierarchical porous zeolite imidazate skeletal material, and a preparation method thereof. The preparation method comprises following steps: 1, a deep eutectic solvent and water are mixed so as to obtain a mixed solvent; 2, a metal salt, and a surfactant are dissolved in the mixed solvent so as to obtain a homogeneous solution, wherein the metal salt is one or a mixture of more than one components selected from zinc salts or cobalt salts; 3, an imidazole derivative is added into the homogeneous solution, and heating stirring is carried out so as to obtain a suspension solution; and 4, the suspension solution is subjected to centrifugation, washing, and drying so as to obtain the hierarchical porous zeolite imidazate skeletal material. The preparation method is simple; the reaction conditions are mild; preparation process is rapid; no environment pollution is caused; the prepared material ishigh in specific surface area and porosity, and possesses a hierarchical porous structure. The obtained hierarchical porous zeolite imidazate skeletal material possesses excellent catalytic activityin CO2 and epoxide cycloaddition reaction.

The invention discloses a 3-trifluoromethyl quinoxalinone compound preparation method which comprises the following steps of in an inert gas atmosphere, adding a quinoxalinone compound, sodium trifluoromethanesulfinate and an oxidant in a solvent, performing reaction for 6-18 h at the temperature of 0-75 DEG C, and performing column chromatography separation and purification to obtain 3-trifluoromethyl substituted quinoxalinone compound. The 3-trifluoromethyl quinoxalinone compound preparation method provided by the invention is low in reagent cost, mild in reaction condition and simple in aftertreatment and is suitable for industrial production.

The invention discloses a blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and a preparation method thereof. The method includes the specific steps of conducting monascus fermentation, water extraction, alcohol extraction, multi-stage micro-encapsulation, spray drying and granulating processes with blood-glucose-lowering ganoderma lucidum sporocarp and conidial powder as raw materials to prepare the blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation. The blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation prepared through the method brings the medicinal value of monascus and ganoderma lucidum into full play, functional components in blood-glucose-lowering ganoderma lucidum are efficiently enriched, the preparation process is green and mild, industrial production is easy, the obtained product has good water dispersity, storage stability and blood glucose lowering function, the use convenience of the product and the bioavailability in human bodies are effectively improved, guarantees are provided for development, application and consumption of the blood-glucose-lowering ganoderma lucidum product, and the preparation has great significance in promoting the development of the blood-glucose-lowering ganoderma lucidum industry and promoting the national health.