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172 results about "Isothiocyanic acid" patented technology
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Thiocyanic acid is a chemical compound with the formula HSCN which exists as a tautomer with isothiocyanic acid (HNCS). The iso- form tends to dominate with the material being about 95% isothiocyanic acid in the vapor phase.
Reagent for detecting mercury ion in water and its preparation method
InactiveCN1752750ADetection fieldQuick checkComponent separationChromatographic separationSynthesis methods
Owner:XIAMEN UNIV
Fractionation of allyl isothiocyanate, p-hydroxybenzyl-isothiocyanate, protein and fiber from mustard
InactiveUS20050031768A1Simple methodExtended shelf lifeOrganic chemistryEssential-oils/perfumesFiberIsothiocyanic acid
Yellow or oriental mustard seed can be fractionated to produce allyl isothiocyanate and p-hydroxybenzyl isothiocyanate, along with prepared mustard products, mustard protein and dietary fiber. Processes for the production of these various fractions from mustard seed stock are disclosed. The seed stock is comminuted with water to yield an activated slurry in which the enzyme myrosinase hydrolyses and deteriorates glycosinolates in the seed stock to isothiocyanates. Remaining slurry can then be sterilized and further conventionally processed to yield improved finished mustard products.
Owner:SAKAI SHIRO
Quasi solid state electrolyte and its preparing process and use
The invention discloses one quartz solid electrolyte and its process method, wherein, the electrolyte comprises ion liquid, inorganic layer materials, single iodide, light anode match agent and isothiocyanic acid through direct mixture method or organic solvent agent mixture evaporation, wherein, the ion liquid is of solvent agent and other element mole concentration as inorganic layer materials for 0.001-10mol / L; single mass iodide for 0.01-1mol / L; iodide; light anode match agent for 0.01-1mol / L; isothiocyanic acid for 0.01-1mol / L.
Owner:TSINGHUA UNIV
Lysis solution and application thereof in tissue or cell preservation and RNA (Ribonucleic Acid) extraction
ActiveCN107475251AAvoid Fragmentation IncompleteAvoid interferenceMicrobiological testing/measurementDead animal preservationSodium acetateIsothiocyanic acid
The invention discloses a lysis solution and an application thereof in tissue or cell preservation and RNA (Ribonucleic Acid) extraction. The lysis solution comprises a lysis solution A and a lysis solution B, wherein the lysis solution A comprises 2-4mol / L guanidinium isothiocyanate, 5-10mmol / L sodium chloride, 10-15mmol / L potassium chloride, the lysis solution B comprises 2-4mol / L guanidinium isothiocyanate, 1-5mmol / L spermidine, 30-40vt% of water saturated phenol, 0.4-0.5mol / L ammonium thiocyanate, 7-8vt% of glycerinum, 0.1-0.5mol / L sodium acetate and 0.2-0.5wt% of SDS (Sodium Dodecyl Sulfonate). When RNA is extracted by using the lysis solution A and the lysis solution B, tissue or cells do not need to be washed, and thus the extraction efficiency is remarkably improved; and due to synergistic effects of the components, the extracted RNA is high in purity and high in yield, and the purpose that animal RNA is extracted in laboratories rapidly with low cost and high quality in a large scale can be realized.
Owner:CHENGDU DAOSHENG BIOTECH CO LTD
Broccoli seed extractive and preparing method thereof
InactiveCN101229211AEasy to carry and useEasy to storePill deliveryAntineoplastic agentsCancer preventionAdditive ingredient
The invention discloses a seed extract of Broccoli and relevant preparation method. The preparation method is to receive the extract of the Broccoli seed hydrolyzing, degreasing, inactivating, and condensing the seed of the Broccoli and to receive a health product by adding auxiliary materials. The main components of the Broccoli extract of the invention is compounds of isothiocyanate; wherein, sulforaphane is the most activated compound with maximal content, and sulforaphane is also the isothiocyanate compound with maximal cancer-prevention activity. The health product containing the Broccoli extracts can effectively help human body improve the resistance to toxicants after the proof of animal experiment, thereby effectively reducing the formation of tumor induced by chemical matters.
Owner:GUANGDONG PHARMA UNIV
Bifunctional fluorescent probe adopting anthracene as matrix, as well as preparation method and application
InactiveCN104788344AEnables fluorescence detectionEnables fluorescence-enhanced detectionUrea derivatives preparationOrganic compound preparationAnthraceneFluorescence
The invention provides a bifunctional fluorescent probe which is provided with the structure of the general formula I and adopts anthracene as the matrix. The preparation method of the bifunctional fluorescent probe comprises the following steps: conducting isocyanic acid esterification or isothiocyanic acid esterification on 9-anthracene methylamine; conducting the nucleophilic addition reaction to obtain the bifunctional fluorescent probe. The bifunctional fluorescent probe has the good fluorescence detection effect on iron ions; moreover, the system composed of the bifunctional fluorescent probe and the iron ions has the selective fluorescence enhanced detection effect on fluorine ions.
Owner:DALIAN UNIV OF TECH
Application of PEI modified carbon dot-FITC compound as rate fluorescent pH probe and Cu2+ fluorescent probe
ActiveCN106085410AExcellent optical propertiesHigh quantum yieldFluorescence/phosphorescenceLuminescent compositionsModified carbonResponsivity
The invention discloses application of a PEI modified carbon dot-FITC compound as a rate fluorescent pH probe and a Cu2+ fluorescent probe. Cherry tomatoes are used as raw materials, carbon dots with fluorescence insensitive to pH changes are prepared through hydro-thermal synthesis, then CDs are modified with PEI, amidogen on PEI react with isothiocyanic acid radicals on FITC molecules, and the compound is formed. The responsivity of fluorescence of FITC in the compound to the pH changes is high, and a rate probe based on CDs and FITC fluorescence is used for pH detection; amidogen on PEI and Cu2+ are subjected to coordination, so that the fluorescence intensity of CDs and FITC is reduced along with increase of the concentration of Cu2+ in a solution, and Cu2+ detection is achieved. According to the constructed fluorescent probe, selected materials are novel, the advantages of being high in sensitivity, good in selectivity, easy to operate, wide in linear range, low in detecting limit and the like are achieved, and the constructed fluorescent probe can be used for efficient detection of the pH and Cu2+ in the aqueous solution and a biological sample.
Owner:QINGDAO UNIV
Liquid crystal compound containing isothiocyanic acid radical as well as preparation method and application thereof
InactiveCN102786456AHigh optical anisotropyImprove propertiesLiquid crystal compositionsOrganic chemistryChemical compoundIsothiocyanic acid
The invention discloses a liquid crystal compound containing an isothiocyanic acid radical as well as a preparation method and an application thereof. The structural general formula of the liquid crystal compound containing the isothiocyanic acid radical is disclosed in a formula I. The compound containing the isothiocyanic acid radical is a liquid crystal monomer; the monomer of the class has bigger optical anisotropy (delta n); and after the monomer is added into mixed liquid crystal, the optical anisotropy of the mixed liquid crystal can be greatly increased so as to improve the property of the mixed liquid crystal. The formula I is as follows.
Owner:SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIALS CO LTD
Polymer nanoparticles capable of detecting hypochlorous acid and copper ions as well as preparation method and application of polymer nanoparticles
ActiveCN106221107AExcellent ratio detectionDecreased fluorescence intensityFluorescence/phosphorescenceMethacrylateIsothiocyanic acid
The invention discloses polymer nanoparticles capable of detecting hypochlorous acid and copper ions. The polymer nanoparticles are novel polymer nanoparticles prepared by taking a polyethylene glycol monomethyl ether chain transfer agent, styrene, 2-aminoethylmethacrylate hydrochloride, rhodamine B isothiocyanate and a 9,9-dioctyl polyfluorene-benzothiadiazole alternate copolymer as raw materials. The polymer nanoparticles can realize high-sensitivity ratio fluorescence detection on the hypochlorous acid and the copper ions in a pure water solution. Compared with an existing fluorescence detection technology, the prepared polymer nanoparticles have a double-ratio detection function and good biocompatibility; a synthetic route is simple and a detection method is simple and convenient; the polymer nanoparticles are applicable to amplified synthesis and actual production application, and have a great application prospect in the technical fields including analytical chemistry, life science, environmental science and the like.
Owner:HUNAN UNIV OF SCI & TECH
Amphipathic fluorescence target nano micelle and its preparation method
InactiveCN1919181AIntuitive and convenient for inspectionSmall particle sizePharmaceutical non-active ingredientsAntineoplastic agentsPolyesterFluorescein
The invention discloses an amphipathic fluorescent targeting nanometer micelle and preparing method, which comprises the following steps: polymerizing decomposable polyester and multi-ammino polymer to synthesize amphipathic drug carrier, adopting solvent evaporating method to prepare carrier micelle, packing the drug into hydrophobic or little water-soluble tumour prevention drug, grafting targeting molecular folacin on the micelle with ammino, grafting isothiocyanic acid fluorescein on the residual ammino.
Owner:TONGJI UNIV
Conjugate of human albumin and 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid useful for the localization of radionuclides for diagnostic and therapeutic purposes
InactiveUS20130330276A1Radioactive preparation carriersPeptide preparation methodsDodecaneIsothiocyanatobenzyl-EDTA
A conjugate of human albumin (HA) and 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (p-SCN-Bn-DOTA) insoluble in aqueous medium at a pH of 3-8.5 and whose IR spectrum shows an absorption at about 700 cm−1 is described; a complex is further described consisting of a conjugate of HA and p-SCN-Bn-DOTA (HAC) according to claim 1 or 2 and a radioactive isotope of an element selected among the group consisting of P, Sr, Rh, Pd, I, Sm, Er, Au, At Bi, In, Lu, Y, Re, Cu and Ag, as well as procedures for preparing said conjugate and said complex as well as the use of such conjugate in the identification of mammalian neoplastic lesions by the R.O.L.L. methodology (“Radioguided Occult Lesion Localization”).
Owner:UNIV DEGLI STUDI DI GENOVA +1
New preparation method of 1-isothiocyanic acid-4-methanesulfonyl-(2-ene) butane
InactiveCN104152504ASimple and fast operationMild reaction conditionsAnimal feeding stuffAccessory food factorsFreeze-dryingIsothiocyanic acid
The invention discloses a new preparation method of 1-isothiocyanic acid-4-methanesulfonyl-(2-ene) butane, and particularly relates to a method for the extraction of sulforaphane from radish seeds or broccoli seeds or rape seeds. According to the method, air-dried radish seeds or broccoli seeds or rape seeds are used as a raw material for preparation of a radish seed crushing liquid, an enzyme deactivated broccoli seed or radish seed dispersion liquid, a degreased fine grinding liquid, a fermentation liquid, a protein removal fermentation liquid, a concentrated liquid, dry polysaccharide powder and high purity sulforaphane freeze-dried powder for preparation of 1-isothiocyanic acid-4-methanesulfonyl-(2-ene) butane with the purity of more than 98%. The production rate of the sulforaphane prepared by the method is high, the operation is simple, and the product has the characteristics of being high in product purity of more than 98%, green, non-pollution and the like. The product prepared by the method can be widely used in medicine and health care industry, and has cancer preventing and resistant function.
Owner:重庆海巨农业发展有限公司 +1
Collecting agent with amide group and thioamide group as well as preparation method and application thereof
ActiveCN109675723AStrong harvesting abilityEnhanced harvesting capacityFlotationSolventIsothiocyanic acid
The invention relates to a collecting agent with an amide group and a thioamide group as well as a preparation method and application thereof. The collecting agent has both the amide group and the thioamide group and has stronger collecting capacity. The preparation method of the collecting agent comprises the following steps: carrying out a reflux reaction of ester containing an isothiocyano group or ester containing an isothiocyano group and an alkoxycarbonyl group, carbonate and amine containing an acetoacetyl group by taking ethanol as a solvent, removing the ethanol and adding hydrochloric acid, so as to obtain the collecting agent with the amide group and the thioamide group. The invention further provides the application of the collecting agent with the amide group and the thioamidegroup in flotation of metal sulfide minerals. The collecting agent in a structure with the amide group and the thioamide group has stronger collecting capacity for precious metal minerals such as chalcopyrites, galena, gold, silver and the like and also has good selectivity for minerals such as pyrites, sphalerites and the like, and the adaptive scope of the pH value of ore pulp is wide.
Owner:CENT SOUTH UNIV
Method And Apparatus For The Enhancement Of The Biocidal Efficacy Of Monoalkyldithiocarbamate Salts
InactiveUS20140088190A1Easy to useBiocideNon-fibrous pulp additionIsothiocyanic acidDrug biological activity
The present invention provides a method of treating an aqueous system for biocide control, by adding an acidified solution that includes monoalkyldithiocarbamate salt and alkyl isothiocyanate to an aqueous system. A biocide feed system is also provided that is configured to generate a reproducible level of alkyl isothiocyanate. The method and system provide effective levels of alkyl isothiocyanate for rapid biocidal activity, along with levels of monoalkyldithiocarbamate salt which can decompose to form additional alkyl isothiocyanate and provide longer-term biocidal activity.
Owner:BUCKMAN LAB INT INC
Isotope labeling reagent as well as preparation method and application thereof
ActiveCN102174025AIncrease signal strengthEasy AdditionOrganic chemistryComponent separationSodium bicarbonateSodium methoxide
The invention discloses an isotope labeling reagent which is an isothiocyanopyrimidine isotope labeling reagent with a chemical name of [d0] / [d6]-4,6-dimethoxine-2-isothiocyanate. The preparation method of the reagent comprises the following steps of: firstly, reacting 4,6-dichloro-2-amiopyrimidine with sodium methoxide / deuterosodium methoxide to obtain a [d0] / [d6]-4,6-dimethoxy-2-amiopyrimidine crude product; carrying out reflux reaction on the obtained crude product, thiophosgene and sodium bicarbonate to obtain a final crude product; and then carrying out column chromatography to obtain the isotope labeling reagent disclosed by the invention. The isotope labeling reagent disclosed by the invention can be applied to the identification analysis of polypeptide N-end residues and the quantitative analysis of protein, can speed up the labeling reaction rate and improve a signal of the labeled peptide section, is beneficial to strengthening the accuracy and the credibility of the identified peptide section and has the advantages of less molecular weight of the labelled part, relative simple structure, stable performance, simpleness and convenience for operation, and the like.
Owner:SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
Naphthylthiourea-modified permethylated beta-cyclodextrin derivative, preparation method and application method thereof
InactiveCN101643517AThe synthetic route is simpleMild reaction conditionsFluorescence/phosphorescenceSolubilityFluorescence
The invention discloses a naphthylthiourea-modified permethylated beta-cyclodextrin derivative, a preparation method and an application method thereof, the chemical formula of the compound is C73H118N2O34S, and the structure and the schematic diagram are shown as attached figures. The compound is simply prepared by the reaction of an amino derivative of cyclodextrin and naphthalene isothiocyanatewith high yield. The compound has high selectivity and high sensitivity on the recognition of mercury ions due to high sulphophile affinity of mercury. The divalent mercury ions are added in the compound in a water phase, fluorescence can be greatly ascended in a short period of time, the detection limit is 50ppb, the compound is resistant to the addition of other ions, such as, Li<+>, Na<+>, K<+>, Mg<2+>, Ca<2+>, Sr<2+>, Ba<2+>, Ag<+>, Cd<2+>, Ce<2+>, Co<2+>, Cu<2+>, Ni<2+>, Pb<2+>, Sr<2+>, Zn<2+> and the like, and the compound has no obvious change after the addition of other ions. The invention provides a reagent and a method which can rapidly test water solubility of the mercury ions in an environment and a biological body with high selectivity, high sensitivity and fluorescence enhancement and is applicable to the wider pH range of (3-12).
Owner:NANKAI UNIV
FRET-based mesoporous silica nanoparticles for real-time monitoring of drug release
A compound comprising: (a) a drug carrier comprising coumarin-labeled-cysteine tethered mesoporous silica nanoparticles (MSNs) loaded with a pharmaceutically active agent, and (b) a fluorescein isothiocyanate-β-cyclodextrin (FITC-β-CD) covalently linked to said cysteine and blocking the release of said pharmaceutically active agent from said nanoparticles, wherein cleavage of said covalent linkage removes said cyclodextrin and releases said pharmaceutically active agent, and said coumarin and said fluorescin form a donor-acceptor pair so that said drug carrier has a first emission wavelength when the covalent linkage is intact and the cyclodextrin said present and a second emission wavelength after cleavage of said covalent linkage to remove said cyclodextrin and release said pharmaceutically active agent.
Owner:RUTGERS THE STATE UNIV
Preparing and application of a reactive mercury ion fluorescence probe
InactiveCN106317063AMild conditionsSimple stepsOrganic chemistryMaterial analysis by observing effect on chemical indicatorMercuric ionThiourea
The invention discloses a reactive mercury ion fluorescent probe and a preparing method as well as application thereof. The method comprises the following steps: (1) 5-aminophenyl and 10, 15, 20- trisulfonate phenyl porphyrin (PNH2) is dissolved in distilled water to form solution of 7.5 mg / ml. The triphosgene is dissolved in dichloromethane to form solution of 5 MuL / mL. After the two is mixed at equal volume, react at room temperature for 3 to 5 hours and then purified, resulted to 5 -phenyl isothiocyanate base and 10, 15, 20 - trisulfate phenylporphyrin (PNCS); (2) 5 - phenyl isothiocyanate base and 10, 15, 20 - trisulfate phenylporphyrin (PNCS) and ethylenediamine derivatives are mixed in an equimolar ratio and dissolved in a mixed solvent of acetone and distilled water, to form a total concentration of 20 mg / mL solution. Finally, the solution reacts at room temperature for 6-10 hours, and after purification, the final product porphyrin-thiourea (PT) is obtained. The probe has good water solubility and shows high sensitivity and selectivity for mercury ions, and shows significant colors and fluorescence changes when detecting mercury ions. Combined with laser confocal scanning microtechnique, the probe can also be obtained the detecting imaging of the mercury ion within living cells.
Owner:ZHEJIANG UNIV CITY COLLEGE
Phosphorescent iridium complex containing isosulfocyanate radical and preparation method and application thereof
InactiveCN101591358AEliminate distractionsNo distractionGroup 8/9/10/18 element organic compoundsColor/spectral properties measurementsSolvent moleculeIridium
The invention discloses a phosphorescent iridium complex containing isosulfocyanate radical. The phosphorescent iridium complex has a structural formula shown as a formula (I), and is an anionic iridium complex, wherein the isosulfocyanate radical can be combined with mercury ion to generate mercuric isosulfocyanate; solvent molecule acetonitrile replaces the isosulfocyanate radical to be coordinated with iridium so as to influence the spectral quality of a generated product; and the mercury ion is detected by the change of the spectral quality, and is not interfered by other metallic ions. The complex can be used for preparing a phosphorescent stoichiometric agent for qualitatively detecting the mercury ion. The invention also provides a preparation method for the phosphorescent iridium complex containing the isosulfocyanate radical.
Owner:SHANGHAI NORMAL UNIVERSITY
Multifunctional coordination copolymer nanometer material as well preparation method and application thereof
InactiveCN103212092AUniform particle sizeGood dispersionNMR/MRI constrast preparationsDispersitySolubility
The invention belongs to the field of medicine materials, and particularly relates to a coordination copolymer nanometer material as well a preparation method and application thereof. The coordination copolymer nanometer material is characterized in that 1,1'-ferrocene dicarboxylic acid-gadolinium nanoparticles are taken as a core, silicon dioxide is taken as a shell, and the surface of the shell is modified by a functional material. The preparation method comprises the following steps of: preparing the 1,1'-ferrocene dicarboxylic acid-gadolinium nanoparticles by a direct precipitation method, then coating the silicon dioxide on the surface of the magnetic nanoparticles so that the surfaces of the 1, 1'-ferrocene dicarboxylic acid-gadolinium nanoparticles carry a quantity of amidogens while the 1,1'-ferrocene dicarboxylic acid-gadolinium nanoparticles have water solubility, connecting to the surface of the 1,1'-ferrocene dicarboxylic acid-gadolinium nanoparticles through rhodamine isothiocyanate B and an amidogen effect, and finally connecting arginine glycine aspartic acid tripeptide through the amidogens. The coordination copolymer nanometer material is uniform in particle size and has good dispersity, a very good magnetic resonance imaging effect of T1 and T2, luminescent property and a target function; the synthetic process is simple; raw materials are easily available; and environmental pollution is avoided.
Owner:SHANGHAI NORMAL UNIVERSITY
Preparation method of magnetic particle with surface modified with isothiocyanato active group
ActiveCN101901656ANo biological toxicityFor long-term storageImmobilised enzymesMicrobiological testing/measurementCross-linkSide effect
The invention provides a preparation method of a magnetic particle with surface modified with an isothiocyanato active group and a special application mode thereof. The preparation method comprises the following steps of: dispersing processed nano and micron grade solid-phase particles with surface modified with amino or sulfydryl active groups into an organic solvent; and mixing the particles with phenylene diisothio cyanate (PDC) for reaction to obtain a functional magnetic complex particle with surface modified with an isothiocyanato (-N=C=S) active group as a functional group. The prepared magnetic particle with surface modified with the isothiocyanato active group realizes that the common functional magnetic particle is rapidly coupled into a biomolecule and avoids toxic and side effects by adopting glutaric dialdehyde as a cross-linking agent in routine operation.
Owner:XIAN GOLDMAG NANOBIOTECH
Photosensitizer Dye
ActiveUS20090216021A1Improve stabilityHigh molecular extinction coefficientMethine/polymethine dyesElectrolytic capacitorsPhotosensitizerAlkoxy group
A theme of the present invention is to provide a new transition metal complex, useful as a photosensitizer dye for a photoelectric conversion element having an excellent durability and a high photoelectric conversion characteristic. The present invention provides a bivalent transition metal complex constituted of (i) a bipyridyl polyacidic ligand, such as a dicarboxybipyridyl (dcbpy) ligand, as an adsorption site for adsorption onto titanium dioxide particle surfaces; (ii) a ligand, selected from the group consisting of an isothiocyanato group, an isocyanato group, and an isoselenocyanato group and enabling absorption and excitation at long wavelengths and charge transfer; and (iii) a bipyridyl (bpy) ligand, having an alkyl group or an alkoxy group, preferably a long-chain alkyl group, and a conjugately bonded thienylvinylene group, aminophenylenevinylene group, et., and improving an absorbance of a transition metal complex and imparting stability against nucleophile to a sensitizer dye that improves an absorption bathochromic effect.
Owner:SHIMANE PREFECTURAL GOVERNMENT MATSUE
Kit for nucleic acid extraction based on magnetic bead method and application thereof
InactiveCN109504678AImprove extraction efficiencyStable environmentDNA preparationMagnetic beadIsothiocyanic acid
The invention discloses a kit for nucleic acid extraction based on a magnetic bead method and application thereof and belongs to the field of molecular biotechnology. The kit comprises a cracking andbinding solution, a buffer solution, washing liquid I, washing liquid II and an eluent; the cracking and binding solution comprises the following components by concentration: 5-8 mol / L of isothiocyanic acid, 60-100 mg / L of glycogen, 10-30 mol / L of Tris-Cl, 1-3 mol / L of EDTA, 0.2-0.5 percent (v / v) of Triton X-100 and 30-40 percent (v / v) of isopropanol; a solvent of the cracking and binding solutionis sterile water. The cracking and binding solution in the kit disclosed by the invention integrates a cracking solution and a binding solution, so that the extraction efficiency is greatly enhanced;in addition, a reagent in the kit is pre-packed in an orifice plate, so that the automatic nucleic acid extraction by the magnetic bead method is realized.
Owner:GUANGDONG FOOD & DRUG VOCATIONAL COLLEGE
Isothiocyanate compounds and isothiocyanate XPO1 protein inhibitor drugs thereof
InactiveUS10315990B2Improve bioavailabilityImprove securityOrganic chemistryAntipyreticSolubilityAryl
Owner:ONCOCURE BIOTECH INC
Gardenia polysaccharide and preparation method and application thereof
ActiveCN111138557AImprove liver fibrosisFacilitate depositionOrganic active ingredientsDigestive systemMedicinal herbsFreeze-drying
The invention discloses gardenia polysaccharide and an extraction method thereof. The gardenia polysaccharide is prepared from the following raw materials (by mass): 41 to 56 percent of total sugar, 34 to 45 percent of uronic acid and 7 to 10 percent of protein. The preparation method of the gardenia polysaccharide comprises the following steps: crushing a gardenia medicinal material, degreasing,adding water, extracting, precipitating with ethanol, repeatedly freeze-thawing to remove protein, dialyzing, and freeze-drying. The gardenia polysaccharide prepared by the method can improve cholestatic liver injury induced by alpha-naphthalene isothiocyanate (ANIT) and 3, 5-diethoxycarbonyl-1, 4-dihydro-2, 4, 6-trimethylpyridine (DDC), and reduce fibrosis induced by carbon tetrachloride (CCL4).And the liver protection effect of the gardenia polysaccharide is not reported in literatures, which indicates that the gardenia polysaccharide has obvious application prospects in the preparation ofliver protection drugs, especially in the preparation of anti-cholestatic liver injury and anti-hepatic fibrosis drugs.
Owner:SHANGHAI UNIV OF T C M
Synthesis and application of thiourea compound with antibacterial activity
ActiveCN107325093AHigh yieldHigh antibacterial activityAntibacterial agentsOrganic chemistryThioureaIsothiocyanic acid
The invention prepares a thiourea compound. The thiourea compound is prepared by the following steps: dissolving a substrate 5-isothiocyanate methyl isoquinoline into anhydrous dichloromethane or anhydrous tetrahydrofuran, adding different aromatic ring substituted thiazole compounds which is equivalent to 1.1 times the weight of the substrate and diisopropylethylamine which is equivalent to 3-5 times the weight of the substrate, stirring at the room temperature for 3-5 hours; after TLC detection reaction is finished, adding ethyl acetate for dilution, washing twice with 5% diluted hydrochloric acid, washing twice with saturated sodium carbonate, washing twice with water, and washing with saturated table salt water; and drying an organic phase with anhydrous sodium sulfate, carrying out reduced pressure concentration, separating through silica gel column chromatography, so as to obtain the target product. The compound has application values in antibacterial aspects and particularly has better antibacterial effects on inhibiting gram-positive bacteria such as staphylococcus aureus than a known antibacterial drug, namely penbritin, so that the thiourea compound can be taken as a novel antibacterial drug to be researched and utilized.
Owner:SOUTHWEAT UNIV OF SCI & TECH
Chitosan oligosaccharide derivative containing thiourea and diethoxyphosphamide structure and preparation method thereof
ActiveCN109021033AImprove biological activityLow reaction temperatureSugar derivativesFungicidesHydrazine compoundThiourea
Owner:INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Application of linear polythiourea and hyperbranched polythiourea in preparation of anti-tumor medicines and anti-virus or anti-bacterial medicines
ActiveCN105582020AStrong growth inhibitory effectLow cytotoxicityAntibacterial agentsOrganic active ingredientsAnti virusThiourea
The invention discloses an application of linear polythiourea in preparation of anti-tumor medicines and anti-virus or anti-bacterial medicines. The linear polythiourea has the structural formula represented as the formula (I), wherein R1 and R2 are independently selected from hydrogen, C1-C10 alkyl groups and aryl groups, or a hetero atom group containing N, O and S. The number-average molecular weight of the linear polythiourea is 50-50000. The invention also discloses an application of hyperbranched polythiourea in preparation of anti-tumor medicines and anti-virus or anti-bacterial medicines. The hyperbranched polythiourea is prepared by dissolving a monomer containing at least two isothiocyanic acid groups or dissolving thiourea with a monomer containing at least two amine groups in an organic solvent, performing a heating condensation polymerization reaction under protection of an inert gas, and purifying a reaction product to prepare the hyperbranched polythiourea.
Owner:ZHEJIANG UNIV
(S)-1-(1-phenethyl) thiourea-modified Cr-Anderson heteropolyacid catalyst, and preparation method and application thereof
ActiveCN105854941AHigh stereoselectivityNoveltyPreparation by oxidation reactionsOrganic compound preparationThioureaIsothiocyanic acid
The invention discloses an (S)-1-(1-phenethyl) thiourea-modified Cr-Anderson heteropolyacid catalyst, and a preparation method and an application thereof. The method comprises the following steps: firstly, reacting ammonium molybdate and chromic nitrate to generate Cr-Anderson heteropolyacid (NH4)3[Cr(OH)6Mo6O18]; carrying out hydrothermal reaction on the Cr-Anderson heteropolyacid and tris(hydroxymethyl)aminomethane in a hydrothermal kettle to obtain an organic unilateral amino-modified polyoxometallate; and with (S)-(+)-1-phenylethylamine as a raw material, synthesizing (R)-1-(1-phenethyl) isothiocyanic acid; and finally reacting (R)-1-(1-phenethyl) isothiocyanic acid and the organic unilateral amino-modified polyoxometallate to obtain the target heteropolyacid catalyst. The preparation method is simple; and the obtained heteropolyacid catalyst is applied to asymmetric dihydroxylation of olefin, is friendly to environment, can be recycled, has high enantioselectivity and high catalytic activity and is suitable for industrial production.
Owner:上海元革新材料科技有限公司
Polypeptide fluorescent probe and preparation method and applications thereof
InactiveCN106929009AImprove detection accuracyThe detection process is fastFluorescence/phosphorescenceLuminescent compositionsChromatographic separationDisease
The invention relates to a polypeptide fluorescent probe. The polypeptide fluorescent probe can be obtained by bonding amino group of polypeptide with isothiocyanate group of fluorescein isothiocyanate, the polypeptide is tetrapeptide DAPD or dipeptide, and the dipeptide is formed by any two of D, A and P amino acids. The preparation method of the polypeptide fluorescent probe comprises the following steps: adding fluorescein isothiocyanate into a reaction container, then dissolving with methanol or water, adding polypeptide so as to cause the molar ratio of the fluorescein isothiocyanate to polypeptide to be (1.2-1.5):1; under the constant temperature condition of 20-40DEG C, stirring and reacting for 4-25h, then performing rotary evaporation to remove a solvent to obtain a crude product; performing high-performance liquid chromatographic separation, purification and drying on the crude product to obtain a needed pure product. From the view of biomimetics, the prepared florescent probe can rapidly and precisely recognize sialic acid, and has important theoretic and practical significance on biochemistry, material science and medicine, especially on the early-stage diagnosis and treatment of serious diseases taking sialic acid as important markers.
Owner:WUHAN UNIV OF TECH
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