3558results about How to "High antibacterial activity" patented technology

The invention is intended for a treatment of severe infections using an injectable drug-delivery system comprising nanoparticles of a biodegradable polymer with incorporated antibacterial drug.

An anti-fungal composition, including: (a) an extract of botanical materials, the botanical materials including material from Echinacea species, and Propolis, which is a material derived from the hives of bees; and (b) an essential oil. The compositions of the present invention have been shown to have unexpectedly prolonged anti-fungal activity, as well as having anti-bacterial and anti-inflammatory activities. Preferably, the essential oil includes at least one oil selected from the group consisting of tea-tree oil, thyme oil and lavander oil. Also preferably, the herbal extract includes a mixture of Calendula, poke root, Echinacea and Propolis extract.

The invention discloses an anti-microbial healing-promoting hydrogel dressing and a preparation method therefor. The main ingredients of the dressing are water-soluble high-molecular polymers, functional polymers with pseudoplastic, anti-microbial agents and water. The above ingredients are dissolved into a whole after a series of technologies. The solution is poured into a mold, and the hydrogel dressing is obtained after curing and irradiation disinfection. The results of wound healing experiments and in vitro anti-microbial experiments show that the hydrogel dressing can promote wound healing effectively, and has good bacteriostatic activity to multiple bacteria (the sterilizing rate is above 70%). The anti-microbial healing-promoting hydrogel dressing is better than existing hydrogel dressings obviously, and has advantages of substantial anti-microbial curative effects, transparency, high water content, simple preparation method, pure product, nontoxicity, innocuousness, no stimulation, good biocompatibility and the like. The hydrogel dressing is suitable for large-area promotion and application.

The invention discloses a high-yield strain streptomyces lydicus, as well as breeding and fermentation thereof. The fermentation of the high-wield stain streptomyces lydicus E9 CGMCC No.3075 comprises the following steps: (1) preparation of a shake flask, seeds and a fermentation medium; (2) shake flask culture; (2) seed culture; (4) fermentation pot culture: leading a seed culture liquid in a fermentation pot filled with the fermentation medium and culturing for 24-96 hours to obtain a high-wield stain streptomyces lydicus E9 fermentation liquor under the condition of ventilating, stirring, temperature of 25-35 DEG C, and pH of 4-9; and carrying out ultrasonication for 20-40 min. The strain of the invention can generate large quantity of substances with antimycotic activity in the fermentation liquor, and the fermentation liquor has evident inhibiting effect on rhizoctonia solani; and the bacterial inhibition rate of the fermentation liquor which is diluted by 50 times reaches above 97.8% after 48 hour fermentation.

The invention discloses a Bacillus velezensis CGMCC (China General Microbiological Culture Collection Center) No.4992 and application thereof in tomato blight antagonism bacteria. A farmland soil sample on which tomatoes are planted for years in Xinjiang Fukang is subjected to antagonism bacteria screening to obtain a strain with stronger bacteriostatic activity; the strain is further screened and domesticated and bred; and the obtained strain is subjected to morphological specificity and 16S rRNA (Ribose Nucleic Acid) sequencing and system development analysis. The antagonism of the fermentation broth of the strain has outstanding technical effect on solving the tomato blight antagonism bacteria and has wide application field.

The invention relates to a Bacillus subtilis T-500. The Bacillus subtilis T-500 has been preserved in CGMCC (China General Microbiological Culture Collection), and the preservation number is CGMCC NO:6058. The Bacillus subtilis T-500 can be used as a biological pesticide for preventing and treating multiple plant diseases, and can also be used as a biological fertilizer for promoting the yield increase of crops. The Bacillus subtilis T-500 has higher antibacterial activity on Magnaporthe oryzae, Pellicularia sasakii, Xanthomonas oryzae, Ustilaginoidea virens, Xanthomonas oryzae pv. oryzicola, Fusarium graminearum, Aspergillus flavus, Aspergillus niger and other pathogenic bacteria, and has better prevention and control effects on diseases caused by the pathogenic bacteria. The Bacillus subtilis T-500 can prevent and treat rice leaf diseases when being diluted 200-500 times on the leaves of rice, can prevent and treat bakanae diseases of rice after seed soaking, and can prevent and treat soil-borne diseases of vegetables and the like after root irrigation.

The invention discloses a polypeptide composition for repairing, whitening and removing wrinkles. The polypeptide composition for repairing, whitening and removing the wrinkles is prepared from the following components is percentage by weight: a repairing polypeptide composition, a collagen supplementing polypeptide composition, a wrinkle removing polypeptide composition, a skin-brightening polypeptide composition, a small molecular active substance, a skin-care activating agent, a pH (Potential of Hydrogen) regulator, a plurality of auxiliary agents and the balance of water, wherein the repairing polypeptide composition comprises palmitoyl tetrapeptide-7 and tripeptide-1-copper; the collagen supplementing polypeptide composition comprises palmitoyl tripeptide-1, palmitoyl tripeptide-5 andpalmitoyl pentapeptide-4; the wrinkle removing polypeptide composition comprises acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and melittin; the skin-brightening polypeptide composition comprises nonapeptide-1, carnosine and tetrapeptide-30. According to the polypeptide composition disclosed by the invention, a novel formula is formed through adjusting ratios of differentpolypeptide components, so that polypeptide effects with different focuses and different applicable ranges; the monarch, minister, assistant and guide thought in traditional Chinese medical science isapplied to the polypeptide composition, so that the formula is diversified and the maximum applicability and applicable range are realized.

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic. Data supplied from the esp@cenet database—Worldwide

The invention discloses a preparation method of a nanoscale zirconium phosphate silver-carrying composite inorganic antimicrobial agent. The preparation method comprises the following steps of 1, a nanoscale zirconium phosphate carrier preparation step specifically comprising that enough sodium dihydrogen phosphate aqueous solution is added into zirconium oxychloride aqueous solution to undergo areaction to produce nanoscale zirconium phosphate carriers, 2, an ultrafiltration step specifically comprising that the nanoscale zirconium phosphate carriers obtained from the step 1 are added into an ultrafilter membrane system for ultrafiltration and when a result of a detection adopting silver ions shows that there is not chloride ions in filtrate, the ultrafiltration is completed, 3, an antimicrobial metal ion adsorption and displacement step specifically comprising that nanoscale zirconium phosphate carrier sol precipitates are dissolved in pure water and then antimicrobial metal ion aqueous solution is added into the nanoscale zirconium phosphate carrier sol precipitate aqueous solution to undergo complete adsorption and displacement reactions, and 4, an inorganic antimicrobial powder preparation step specifically comprising that reaction products obtained from the step 3 are filtered by a pump and washed to form filter cakes and the filter cakes is dried by an oven, crushed slightly and calcined to form finished products. The preparation method removes an inorganic salt by-product from a zirconium phosphate synthesis process through adopting an ultrafilter membrane thus enables zirconium phosphate carriers to be utilized directly for adsorption and displacement of metal ions without high-temperature calcination.

The invention concerns agents with anti-bacterial activity and methods and intermediates for their production. The present invention further concerns the use of such agents for the treatment of bacterial infections in animals, including man. The agents are derivatives of vancomycin-type antibiotics, of structure: V-L-W-X; wherein V is a glycopeptide moiety which inhibits peptidoglycan biosynthesis in bacteria; L is a linking group; W is a peptidic membrane-associating element such as an element based on naturally-occurring animal or bacterial peptide antibiotics; and X is hydrogen or a membrane-insertive element.

The invention provides a new compound and a preparation method and application thereof. The structure of the compound provided by the invention is shown as a formula (1). Four-potential hydroxyl of glycosyl on benzyl hydroxyl of peptide framework six-potential amino acid of the compound serves as an axial bond and the compound is obtained by fermentation and has the collection number of China General Microbiological Culture Collection Center (CGMCC) No.3053. The compound provided by the invention has high antibiotic activity, so that the compound plays a very important role in developing a new antibacterial medicament.

The invention discloses an edible fishskin collagen antibiosis membrane and a preparing method thereof, wherein fishskin collagen, chitosan, plant essential oil, soya bean lecithin and glycerol are contained in component of the membrane. The preparing method includes: firstly dissolving the fishskin collagen powder in distilled water to prepare fishskin collagen solution, dissolving the chitosan in chitosan solution prepared by acetic acid solution, dissolving the plant essential oil in distilled water of the soya bean lecithin to prepare plant essential oil solution, mixing the three solutions, adding in the glycerol as the plasticizer, evenly stirring, standing for degassing, and removing and spreading the obtained solution on an organic glass framework for drying to obtain the membrane. The edible fishskin collagen antibiosis membrane has good antibiosis performance, can be biodegraded, causes no pollution to the environment, can restrain growing of microorganisms on the surface of food and accordingly has the effect of food refreshment and shelf life extending.

The invention relates to bactericidal formulations that come into contact with human body, particularly wash formulations including liquid soaps, comprising perfume ingredients active against gram-negative bacteria. Such compositions contact the target site, for example the skin surface, only for a short time, usually not longer than 30 seconds. Therefore the antibacterial action has to be of the bactericidal type and rapid. Furthermore, the bactericidal activity has to be sufficiently high to ensure an effect even when applied to wet substrates that will dilute the bactericidal formulation.

A composite chitosan/copper antibacterial agent with broad spectrum is prepared proportionally from chitosan and Cu ions through purifying chitosan, coordination with Cu ions, depositing in the mixed solvent of acetone and alcohol, washing and drying.

The invention discloses an isoflavone compound in a tobacco rhizome and a preparation method and application thereof. The preparation method comprises the following steps of: crushing a tobacco rhizome sample, performing ultrasonic extraction for 3 to 5 times by using 95 percent ethanol, combining the extracts, filtering, performing reduced pressure concentration to obtain an extract, primarily separating the extract by using silica gel column chromatography, further separating the extract by adopting high performance liquid chromatography, and thus obtaining the required new compound. Antibacterial activity screening test results show that the compound has strong antibacterial effect on common proteus species, escherichia coli, staphylococcus, bacillus subtilis and the like. The compound used for cigarette tipping paper plays an obvious role in inhibiting microbes for polluting the cigarette tipping paper.

The invention relates to a novel active packaging film. The active packaging film is characterized in that a film-forming base material is polyvinyl alcohol; a film-forming assistant contains ethylene glycol and lauryl sodium sulfate. The novel active packaging film contains broad-spectrum long-acting antibacterial beta-cyclodextrin inclusion compound particles. The inclusion compound particles account for 4-24 percent of the weight of the active antibacterial film. The particles are 1-100 nanometers in particle size; through the slow release of essential oil in the inclusion compound and the migration in the film, an antibacterial action is performed on surfaces of foods finally. The active packaging film provided by the invention is a colorless transparent film which is light in spice smell, consistent in thickness, fine and smooth in hand feeling and better in mechanical property, is not obvious in bubbles, is complete, bright and clean, and is capable of meeting the mechanical requirement of food packaging. The transparency is good, so that content held in the active packaging film can be clearly seen when the active packaging film is used for packaging the foods.

The invention discloses a green antimicrobial cleanser essence as well as a preparation method and application thereof. According to the invention, the green antimicrobial cleanser essence is prepared from an antimicrobial agent, 15.0-45.0% of natural surfactant, 0.1-0.3% of chelating agent, 2.0-5.0% of thickening agent and 0.3-0.9% of composite antimicrobial agent, wherein the antimicrobial agent is a composition of nano silver and natural plant extractives at a mass ratio of 1:5 to 1:1. The antimicrobial activity of the cleanser essence is greatly improved due to the antimicrobial synergistic effect of nano silver and the natural plant extractives; the cleanser essence has the following characteristics of wide antimicrobial spectrum and high antimicrobial efficiency and can be used for removing dirt and pesticide residues as well as peculiar smell while sterilizing effectively, so that the purpose of removing dirt, pesticide residues, harmful microorganisms and peculiar smell at one step is achieved. The preparation method is simple in preparation process, low in cost and capable of being applied to industrial mass production. The prepared green antimicrobial cleanser essence is high in anti-microorganism efficiency, free of toxicity and stimulation, environment friendly, bio-gradable and free of residues after being used so as to be used for cleaning dishes, fruits and vegetables.

Belonging to the field of biomedical materials, the invention relates to a preparation method of a polysaccharide-nanometer bacterial cellulose composite wound dressing. The method specifically consists of the steps of: taking a nanometer bacterial cellulose membrane for pretreatment and purification treatment so as to obtain purified nanometer bacterial cellulose, then preparing a polysaccharide solution with a concentration of 0.1-10%, removing part of water from the nanometer bacterial cellulose membrane, then compounding it with a polysaccharide solution by means of soaking, tape casting or spraying so as to obtain a polysaccharide-nanometer bacterial cellulose composite membrane, then conducting extrusion dewatering and ionizing radiation disinfection, thus obtaining the polysaccharide-nanometer bacterial cellulose composite wound dressing. The dressing of the invention has the advantages of good biocompatibility, cellular affinity and antibacterial property as well as mechanical property, excellent permeability, breathability or drainage, and moisture absorption effects, and has the efficacy of sterilization, inflammation diminishing, hemostasis, pain relieving, infection reduction and the like. At the same time, the dressing can promote wound surface drying, incrustation and healing, and can be used to treat burns or scalds, open wounds, ulcers, chronic wounds and stubborn infected wound surfaces, etc.

The invention is directed to an ion plasma deposition (IPD) method adapted to coat polymer surfaces with highly adherent antimicrobial films. A controlled ion plasma deposition (IPD) process is used to coat a metal or polymer with a selected metal/metal oxide. Exposing the coated surface to ultraviolet light significantly improves the antimicrobial properties of the deposited coatings.

The invention belongs to the field of daily chemicals, and specifically relates to an antibacterial liquid laundry detergent, a preparation method and applications thereof. The antibacterial liquid laundry detergent comprises the following components in percentage by weight: 0.3 to 0.9% of composite antibacterial agent, 5 to 20% of anionic surfactant, 5 to 20% of nonionic surfactant, 0.05 to 0.5% of fluorescent whitening agent, 0.05 to 5% of chelating agent, 0 to 1% of pH adjuster, 0.1 to 1% of essence, and the balance being water. The composite antibacterial agent is prepared according to a mass ratio of 1:1-5 of nano silver to a plant origin antibacterial agent. The nano silver and plant origin antibacterial agent can generate a synergetic effect, the antibacterial activity is largely improved, and thus the bacteria can be effectively removed. Furthermore, the raw materials are easily available, the preparation technology is simple, the cost is low, and the preparation method can be applied to industrial production. The prepared antibacterial liquid laundry detergent is nontoxic, nonirritant, and environment-friendly and can be easily degraded by organisms.

The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula I

with the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

The invention provides a new chitosan derivate-chitosan biguanide muriate, its preparation and usage, in which, the repeat unit is 2-biguanide glucose muriate, the substitution degree of guanidine is 15-50%, and the molecular weight is 0.5-25 ten thousand. This invention uses the reaction of chitosan and dicyandiamide to prepare chitosan biguanide muriate, and has advantages of mild reaction conditions and fewer side effects. The product has good antibacterial activity and water solubility, and can be widely used in medicine, textile industry, agriculture and other fields.

The invention discloses a preparing method of east Asia Tityus antibiotic peptide gene and appliance, which comprises the following steps: restructuring bacillus coli Escherichia coli DH5a/BmKAMP1, CCTCC NO: M207036; constructing east Asia Tityus ioterium cell cDNA library; choosing PCR method; sieving positive colony of scorpion antibiotic peptide gene from ioterium cDNA library; sequence-analyzing coding trait of antibiotic peptide gene; assuring amino acid sequence of the antibiotic peptide gene; adopting chemosynthesis antibiotic peptide; possessing inhibition of diverse density for Gram's bacterium. This antibiotic peptide possesses specificity and high active, which can be used as antibacterial drugs.

The invention provides therapeutic antimicrobial compositions and methods for their use based on natural organic phenolic compounds combined with pharmacological agents. The antimicrobial activities of each carvacrol and thymol are believed to be enhanced, while the pharmacological properties of procaine and related compounds are added to provide their unique properties to facilitate usefulness and effectiveness in humans. The therapeutic compositions are active against bacterial, fungal, and protozoan infections. The forms of the invention are intended to treat various internal infections through parenteral, subcutaneous, intradermal, intravenous, and intramuscular injections. They are also intended as useful agents to treat microbial infections that have become resistant to conventional anitibiotics as well as secondary opportunistic infections.

The invention discloses a cefepime antibacterial drug comprising cefepime and beta-lactam enzyme inhibitor by the ratio by weight of 1:2 to 1:0.1, wherein the cefepime is cefepime inner salt, or cefepime hydrochlorate, or cefepime hydrochlorate hydrate, or one of the former medicaments with added adjunct (L-arginine, or sodium carbonate, or sodium hydrogen carbonate, the beta-lactam enzyme inhibitor can be Tazobactam, or clavulanic acid, or tapazole or their derivatives.