134results about How to "Adjustable mechanical properties" patented technology

The invention relates to an apparatus(100) and a method for the processing of single molecules, particularly for the sensing or sequencing of single-stranded DNA. A bottom layer(110) and an electrically conductive top layer(120) with a first and a second slit(111,121), respectively, are disposed on top of each other such that an aperture(A) is formed by the slits. The slits(111,121) are preferably perpendicular to each other. An electrical circuit(140) may be connected to the top layer(120), allowing to sense single molecules that pass through the aperture(A).

The invention relates to core-shell structured carbon-silicon carbide composite nano-fibers based on a coaxial electrostatic spinning process and a preparation method thereof. The preparation method comprises the following steps: (1) taking a polycarbosilane (PCS) solution and a polyacrylonitrile (PAN) solution as a shell-layer precursor and a core-layer precursor respectively; (2) carrying out electrostatic spinning on the shell/core precursor by using electrostatic spinning equipment with a coaxial needle so as to obtain precursor fibers with a core-shell structure; and (3) carrying out non-smelting treatment and high-temperature pyrolysis treatment on the precursor fibers to finally obtain C-SiC composite fibers with a core-shell structure. The invention provides the novel process method for preparing the core-shell structured composite fibers with carbon fiber cores covering ceramic-phase SiC shells, which have a controllable micro-structure, high efficiency and low cost; and the prepared composite fibers overcome the disadvantage that ceramic fibers are relatively fragile, and functional properties of high intensity and flexibility of the fiber and internal conduction and external insulation are realized.

The invention relates to medical porous polyether-ether-ketone with a drug loading function and a preparing method and application thereof. The medical porous polyether-ether-ketone has a uniform porous structure or gradient change type porous structure, pore size is 0.05-2 mm, and porosity is 10-90%. During preparation, molten polyether-ether-ketone is extruded into preform pores through pressure casting, and then preform is etched off with the chemical method to form the porous polyether-ether-ketone. The material has excellent mechanical property, and pore size and porosity are controllable. The porous structure of the material can be loaded with drugs to prevent infection and promote bone growth and healing. Compared with the prior art, the medical porous polyether-ether-ketone with the drug loading function and the preparing method and application thereof have the advantages that operation is easy, structure is controllable, drug loading is convenient, drug binding is firm, and cost is low.

The invention relates to a gel casting preparation method for a medical multi-hole titanium-cobalt alloy implant. The gel casting preparation method pertains to the technical field of the medical material preparation. Acrylamide monomer, a crosslinking agent N, N'-methylene-bisacrylamide and deionized water are prepared into a premixed solution with a certain concentration; a dispersing agent oleic acid is added to the premixed solution to lead titanium-cobalt alloy powders to suspend in the premixed solution so as to prepare a slurry body; the pH value is adjusted to 9.0 to 10.0, then a proper amount of catalyst N, N, N', N'-TMEDA (tetramethylethylenediamine) and an evocating agent ammonium persulfate are added to the slurry body and are evenly stirred, then the slurry body is injected to a mold after being degassed; monomers in the mold undergo polymerization, therefore, a meshy structure is formed to cover the titanium-cobalt powders, then a blank body meshy-shaped by large molecules is formed. A product is obtained after the blank body is dried, batched out and sintered. In addition, the porosity and the mechanical property of the multi-hole titanium-cobalt alloy can be changed through adjusting the solid content, so as to meet the performance requirements of various medical implants. The gel casting preparation method for the multi-hole titanium-cobalt alloy medical implant requires no complicate devices and special degreasing techniques, has simple process, can greatly reduce production costs, and is particularly applicable to the medical implants with the characteristics of various specifications and mass production.

The invention relates to application of a porous magnesium alloy as a carrier in medicine. Drugs can be carried onto the porous magnesium alloy to be used as a blood vessel stent, bone repair or bone propping material. The porous magnesium alloy is prepared by direct foaming, corrosion pore forming, laser drilling, powder metallurgy, quick forming, co-permeation vibration, 3D printing and the like. Laser cladding, microarc oxidation, anode oxidation, osmosis, embedding, solvent evaporation drying, melting, adsorption equilibrium and the like are performed to carry drugs into the porous magnesium alloy surface or the inside of the porous structure, thereby performing the functions of increasing the surface activity, promoting the bone cell growth and differentiation, preventing infection, implementing specific drug delivery and partial drug delivery and the like. The preparation method is simple to operate and easy to implement, and has the advantages of controllable structure, convenient drug carrying, firm drug combination, low cost and the like.

The invention provides an anti-bacterial-adhesion conductive hydrogel and a preparation method and application thereof, and belongs to the technical field of functional polymer materials. According tothe method, silver nanoparticles modified by synthesized polydopamine are compounded in a solution of a conductive polymer monomer and polyvinyl alcohol, polymerization is initiated by using an initiator, and the conductive hydrogel is prepared in situ. The hydrogel has good biocompatibility, high bioadhesiveness, excellent electrical conductivity, excellent antibacterial properties for Gram-negative bacteria and Gram-positive bacteria and adjustable mechanical properties. The anti-bacterial-adhesion conductive hydrogel can be used as a novel medical polymer wound dressing, which has potential biological and medical application value in promoting wound healing of the body.

A biodegradable and bioactive medical tissue adhesive with high bilcompatibility and adjustable mechanical strength and degradating speed for adhering soft tissue and hard tissue is prepared from the liquid phase (hydroxyethyl methylacrylate ring- opening polymerized cycloester type macro-molecular monomer), the alcohol type compound (biodegradable cross-linking agent, vinylpyrrolidone, N,N-dimethyl p- tolueneamine, or hydroquinone), and the solid phase (encapsulated natural powder, pore-forming agent, and benzoly peroxide) through mixing.

The invention provides a preparation method of zirconium boride-silicon carbide/graphite layered superhigh temperature ceramic. The preparation method is characterized by comprising the following steps: 1) separately preparing a zirconium boride casting sheet and a zirconium oxide casting sheet by using a casting method, namely, adding a binder and a plasticizer in a solvent and evenly mixing, separately adding a zirconium boride ceramic powder material and a graphite ceramic powder material, and evenly mixing to form a casting material, then carrying out casting forming, and drying at room temperature and demoulding to respectively obtain the zirconium boride casting sheet with the thickness of 200-1000 mu m and the graphite casting sheet with the thickness of 20-100 mu m; 2) respectively slicing the zirconium boride casting sheet and the graphite casting sheet according to the size of a mould; 3) putting the zirconium boride sheet and the graphite sheet in a graphite mould in an alternatively overlapping way for vacuum derosination; and 4) hot pressed sintering in an argon atmosphere to prepare the layered superhigh temperature ceramic. According to the invention, preparation process is simple, cost is low, the machinability of the material is strong, compositions are controllable, and the toughness of the material is up to 11.3MPa.m<1/2>.

The invention relates to an application of porous titanium alloy in medical science as a carrier. The application comprises the following steps: 1, winding and braiding medical titanium alloy wires to prepare porous titanium alloy; and 2, loading a drug to the surface or the porous structure of the porous titanium alloy through laser cladding, micro-arc oxidation, anodization, osmosis, an entrapping method, a solvent volatilization, a melting method or an adsorption balancing method. The porous titanium alloy can be used as an artificial joint, spinal column fusion, bone filling, bone restoration or bone transplantation material in order to realize surface activity increase, osteocyte growth and differentiation promotion, infection prevention, targeted administration and local administration effects. Compared with carriers in the prior art, the porous titanium alloy used as the carrier has the advantages of simplicity and easiness in operation, controllable structure, convenience in drug load, firm drug combination and low cost.

The invention relates to a biodegradable hydroxylapatite-magnesium and calcium metallic matrix composite, belonging to the field of biomedical materials. The material of the invention is composed of the composite of magnesium-calcium alloy and hydroxylapatite particles, the components and mass percent thereof are: 0.01-5% of Ca, 0-1% of Zn and Mg as the balance; the mass ratio of the hydroxylapatite to magnesium-calcium alloy is 0.01-50:100. In the invention, powder metallurgic method is adopted. The material matrix of the invention has close bonding with strengthened nano particles which areevenly distributed. The composite of the invention can be biologically degradable and has fine mechanical property and biological activity, and wide application prospect in medical material field such as repairing impairment of scaffold for bone tissue engineering, fixed fasteners within bones and weight-bearing parts of bones.

The present invention relates to a self-plasticizing vinyl chloride-based copolymer, a method for preparing the self-plasticizing vinyl chloride-based copolymer, a composition comprising the self-plasticizing vinyl chloride-based copolymer, and a resin product made from the composition. The self-plasticizing vinyl chloride-based copolymer has excellent self-plasticizing properties and processability; and products made from the vinyl chloride-based copolymer also have excellent biological properties. The invention provides the self-plasticizing vinyl chloride-based copolymer. The self-plasticizing vinyl chloride-based copolymer comprises a structural unit (a) based on vinyl chloride and a structural unit (b) based on a monomer represented by formula (1): CH2 = CR1COO (R2O) xR3 (1), whereinR1 is at least one selected from the group consisting of hydrogen and a linear or branched alkyl group having 1-6 carbon atoms, and R2 is at least one selected from the group consisting of hydrogen and a branched alkyl group having 1-6 carbon atoms. The number x of repeating units is an integer selected from 2-20, each R2 is selected from a linear or branched alkylene group having 2-10 carbon atoms, and the R2 may be the same or different; and R3 is at least one selected from the group consisting of hydrogen and a linear or branched alkyl group having 1-4 carbon atoms.

The invention relates to a medical drug-loaded metal-macromolecular gradient porous composite. A medical polymer material is adopted as a matrix of the metal-macromolecular gradient porous composite, and a porous material woven from medical metal wires in a wound mode is adopted as a wild phase, wherein the volume fraction of the matrix ranges from 10% to 90%; according to the metal-macromolecular gradient porous composite, the matrix is extruded into a hole of the wild phase, then part of wild phase metal is removed through a chemical corrosion method, and the gradient porous material with a porous surface and a solid interior is formed. Compared with the prior art, the material has the excellent mechanical property and good bone transmission and inducing capacity, and the surface layer porous layer thickness, the pore size and porosity can be controlled. Drugs can be loaded into the surface layer porous layer according to needs, and the functions of preventing infection and promoting bone growth and healing are achieved. A preparation method has the advantages of being easy to operate and practicable, low in cost and the like.

Optical components are flip chip mounted onto a substrate for improved alignment. Each device is fabricated using “build-up” layers above a substrate. Each has an optical confinement region in which optical radiation travels in use, and a bonding surface. The overall depth of the layers above the optical confinement region is closely controlled during fabrication, for instance by the use a “spacer” layer, so that when the devices are subsequently flip chip mounted adjacent one another on a shared substrate by means of their bonding surfaces, they can be passively positioned so that their optical confinement regions abut and optical radiation can be coupled from one to the next in use.

The invention discloses metal ion cross-linked hydrogel and a preparation method and application thereof. Hydrazide group modified water-soluble macromolecules are prepared through a carbodiimide method, then a hydrazide polymer aqueous solution and a metal ion solution are mixed to be uniform, and the metal ion cross-linked hydrogel is obtained. The hydrogel disclosed by the invention takes metalions as a cross-linking agent, has the advantages of controllable gelling time, adjustable mechanical properties, self-healing property and the like, and is simple in preparation method, mild in process conditions and wide in applicable metal ion variety. The hydrogel disclosed by the invention has a wide application prospect in the fields of three-dimensional tumor model construction, tumor local treatment, biomedical diagnosis and treatment agents, wound antibacterial dressings, drug delivery, removal of heavy metal ions in sewage and the like.

The invention relates to a preparation method of a short-peptide/silicon dioxide/hydroxyapatite porous composite material, belonging to the technical field of preparation of biological composite materials. The short-peptide/silicon dioxide/hydroxyapatite porous composite material can be used as a bone-repairing three-dimensional scaffold material, has good biological activity, mechanical property and degradation characteristic, and is beneficial to improvement of the bone repairing effect. The preparation method comprises the steps of dissolving short-peptide molecules into water for assembly; mixing the assembled short-peptide solution, a silicon precursor and an adhesive, and reacting to form short-peptide/silicon dioxide gel; replacing the gel by using ultra-pure water and then freezing a sample by using a condensation induction method and carrying out freeze-drying to obtain a short-peptide/silicon dioxide porous material; soaking the material by using simulated body fluid, and carrying out freeze-drying to obtain the short-peptide/silicon dioxide/hydroxyapatite porous composite material. The short-peptide/silicon dioxide/hydroxyapatite porous composite material is used for preparing an organic/inorganic porous composite material, has a hierarchical porous structure which is easy to regulate and control, and can be applied to the field of bone repairing as a three-dimensional scaffold of an artificial bone material.

The invention discloses a nano hybrid silk fibroin hydrogel and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The nano hybrid silk fibroin hydrogel is prepared by pre-blending a regenerated silk fibroin aqueous solution and nano hydroxyapatite and performing ultrasonic treatment. According to the preparation method of the nano hybrid silkfibroin hydrogel, the ultrasonic condition and the mixing ratio of the two materials are changed, the gelation time is controlled, and rapid gelation is realized, so that use of a potentially toxic chemical crosslinking agent is avoided, and activity of cells or biological factors can be well maintained. The nano hybrid silk fibroin hydrogel provided by the invention has controllable gel performance, controllable mechanical performance, good cell compatibility and good bone induction capability, can load stem cells for repairing bone defect, and is expected to be used for embedding active factors for synergistic treatment.

The invention discloses light/heat double crosslinked hyperbranched polycarbosilane benzocyclobutene resin as shown in a formula (IV) and a preparation method thereof. The preparation method of the hyperbranched polycarbosilane benzocyclobutene resin comprises the following steps: generating a Grignard reagent from chloromethyltrichlorosilane under the action of magnesium; then performing a coupling reaction with Si-Cl to further form a hyperbranched Si-Cl bond-containing hyperbranched polycarbosilane polymer; adding 4-bromobenzocyclobutene to react; adding p-bromostyrene to react; then adding alkyl (alkenyl) halide to react; performing cooling; adding distilled water (deionized water) into the system for a quenching reaction; and performing solvent extraction, concentration, and purification steps such as distillation or column chromatography on silica gel to obtain the light/heat double crosslinked hyperbranched polycarbosilane benzocyclobutene resin. The light/heat double crosslinked hyperbranched polycarbosilane benzocyclobutene resin prepared by the method is excellent in thermal, electrical and photosensitive properties and is suitable for being used as a high performance dielectric film material or a packaging material in the field of microelectronics industry, space flight and aviation and national defense and the like. The formula (IV) is as shown in the specification.

The invention provides a preparation method of nano-composite hydrogel and application of the nano-composite hydrogel in promoting healing of diabetic wounds. The method comprises the following steps: preparing a functionally modified natural high-molecular polymer and functional metal oxide nanoparticles, mixing the functionally modified natural high-molecular polymer solution with the functional metal oxide nanoparticles, and finally preparing the nano composite hydrogel by means of enzymatic crosslinking and photo-crosslinking. The hydrogel prepared by the method has multiple functions, and can be used for adjusting the pathological microenvironment of the diabetic wound to promote the healing of the diabetic wound.

The invention discloses a TBJ tissue repair film type stent and a preparation method thereof. The TBJ tissue repair film type stent comprises three layers of regional structure with gradient changes:a polymer/ceramic composite material area, a polymer area and a polymer/ceramic composite material area. The preparation method comprises the following steps: firstly, obtaining the polymer film and the polymer/ceramic composite film through blending and hot-press molding, splicing the two films, carrying out hot-press fusion, and then performing axial mechanical stretching along the vertical direction of the interface of the connecting line to obtain the film type TBJ stent. The stent material is biomimics TBJ tissue in design, has multiple gradient characteristics of material component, structure and mechanical property changes, further has effects of mechanical enhancement and composite regulation of ion and mechanical signals, which is a tendon-bone repair stent material with high bionic tissue characteristics and excellent mechanical properties, and can be applied to regeneration induction and functional reconstruction of cells and extracellular matrixes in the tendon-bone junction.

The invention provides a preparation method of zirconium boride-silicon carbide/boron nitride lamellar ultrahigh-temperature ceramic. The preparation method of the zirconium boride-silicon carbide/boron nitride lamellar ultrahigh-temperature ceramic is characterized by comprising the following steps of: (1) respectively preparing a zirconium boride casting sheet and a boron nitride casting sheet by adopting a casting method: firstly adding a binder and a plasticizer to a solvent, uniformly stirring, then respectively adding zirconium boride ceramic powder and boron nitride boride ceramic powder, uniformly stirring to form casting materials, then carrying out casting forming, and drying and demoulding at room temperature to respectively obtain the zirconium boride casting sheet with the thickness of 200-1000 micrometers and the boron nitride casting sheet with the thickness of 20-100 micrometers; (2) respectively slicing the zirconium boride casting sheet and the boron nitride casting sheet according to the size of a mould; (3) alternately overlapping the zirconium boride slices and the boron nitride slices, placing into a graphite grinding tool, and degreasing in vacuum; and (4) carrying out hot pressed sintering in an argon atmosphere to prepare the lamellar ultrahigh-temperature ceramic. The invention has simple preparation process, low cost and controllable component; and in addition, an obtained material has higher high-temperature oxidation resistance and reaches high fracture toughness at 18.1 MPa.m<1/2>.