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Biodegradable hydroxylapatite-magnesium and calcium metallic matrix composite

A technology of hydroxyapatite and composite materials, applied in medical science, prosthesis, etc., to improve hardness and elastic modulus, promote differentiation and proliferation, and improve toughness

Inactive Publication Date: 2009-09-09
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the aluminum element in AZ91 used by German scholars has neurotoxicity and is a factor leading to neurological disorders and Alzheimer's disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 120.1440g of Mg blocks with a purity of not less than 99.99%, and 0.9647g of Ca particles with a purity of not less than 99.999%. Using vacuum melting, graphite crucible. The melting temperature is 1073K. Steel casting. After the magnesium-calcium ingot is turned into small pieces of metal chips, it is ultrasonically cleaned with acetone solution, and then put into a ball mill for ball milling. The ball milling process is protected by argon. Ball milling is about 2 hours, the ball milling speed is 500 rpm, and the metal chips are ground into powder. Add about 12.3428g of hydroxyapatite powder, ball mill together for about 20 minutes, and the ball milling speed is 361 rpm. The evenly mixed powder is put into a mold and cold-pressed on a universal testing machine. After sintering at 753K for 3 hours and hot extrusion at this temperature. The material has good biological and mechanical properties, its tensile strength and deformation are respectively 253MPa and 8%, an...

Embodiment 2

[0041] 82.6775g of Mg powder with a purity of not less than 99.9%, 1.6400g of Ca particles with a purity of not less than 99.999%, and 0.1652g of Zn particles with a purity of not less than 99.75%. Using vacuum melting, graphite crucible. The melting temperature is 993K. Steel casting. After the magnesium-calcium ingot is turned into small pieces of metal chips, it is ultrasonically cleaned with acetone solution, and then put into a ball mill for ball milling. The ball milling process is protected by argon. Ball milling takes about 1.5 hours, the ball milling speed is 500 rpm, and the metal shavings are ground into powder. Add about 4.2358g of hydroxyapatite powder, and ball mill together for about 20 minutes, the ball milling speed is 361 rpm. The evenly mixed powder is put into a mold and cold-pressed on a universal testing machine. After sintering at 773K for 3.5 hours and hot extrusion at this temperature. The material has good biological and mechanical properties, it...

Embodiment 3

[0043] 120.2567g of Mg powder with a purity of not less than 99.99%, 6.3831g of Ca particles with a purity of not less than 99.999%, and 1.0221g of Zn particles with a purity of not less than 99.75%. The melting process adopts argon protection and graphite crucible. The melting temperature is 1023K. Copper casting. After the magnesium-calcium ingot is turned into small pieces of metal chips, it is ultrasonically cleaned with acetone solution, and then put into a ball mill for ball milling. The ball milling process is protected by argon. Ball milling is about 2 hours, the ball milling speed is 500 rpm, and the metal chips are ground into powder. Add about 25.4002g of hydroxyapatite powder, ball mill together for about 30 minutes, and the ball milling speed is 361 rpm. The evenly mixed powder is put into a mold and cold-pressed on a universal testing machine. After sintering at 773K for 3 hours and hot extrusion at this temperature. The material has good biological and mech...

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PUM

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Abstract

The invention relates to a biodegradable hydroxylapatite-magnesium and calcium metallic matrix composite, belonging to the field of biomedical materials. The material of the invention is composed of the composite of magnesium-calcium alloy and hydroxylapatite particles, the components and mass percent thereof are: 0.01-5% of Ca, 0-1% of Zn and Mg as the balance; the mass ratio of the hydroxylapatite to magnesium-calcium alloy is 0.01-50:100. In the invention, powder metallurgic method is adopted. The material matrix of the invention has close bonding with strengthened nano particles which areevenly distributed. The composite of the invention can be biologically degradable and has fine mechanical property and biological activity, and wide application prospect in medical material field such as repairing impairment of scaffold for bone tissue engineering, fixed fasteners within bones and weight-bearing parts of bones.

Description

technical field [0001] The invention relates to a biodegradable hydroxyapatite-magnesium-calcium metal matrix composite material, specifically, a biocomposite material with magnesium-calcium alloy as the matrix and hydroxyapatite as the reinforcement, belonging to biomedical materials field. Background technique [0002] Magnesium and magnesium alloys are biodegradable and are ideal metal materials for bone tissue repair and replacement. Compared with commonly used biometallic materials, (1) there is about 1 mole in the human body, about half of which is stored in bone tissue. Its density (1.74~2.0g / cm 3 ) is much lower than medical titanium alloy (4.4 ~ 4.5g / cm 3 ), and human bone density (1.8 ~ 2.1g / cm 3 )similar. (2) It has high specific strength and specific stiffness, Young's modulus is 41-45GPa, which is less than 1 / 2 of that of titanium alloy (110-117GPa), which can effectively alleviate the stress shielding effect. (3) It is the second most important cation in ...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/58A61L27/12A61L27/04
Inventor 高家诚张敏
Owner CHONGQING UNIV
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