324 results about "Biocomposite" patented technology

A process for the manufacture of natural fiber and polymer composites is described. Thermoplastically processed plasticized soy flour based plastics are used with thermoplastic polymers. Polymers of soy flour and an in situ polymerized polyvinyl polymer which links proteins and carbohydrates in the flour to form the polymer are used. The composites are useful in engineering materials.

The invention relates to a preparation method of an electrochemical biosensor, and particularly relates to a preparation method of a dehydrogenase-electrochemical biosensor. The method comprises the following steps of: preparing nano biocomposite from all components (including a carbon nanomaterial, an electronic mediator, a high-molecular polymer, dehydrogenase, coenzyme and buffer solution) required for modifying electrodes in a preparation process of the sensor; and modifying the composite material to the surface of a screen-printed electrode by a simple one-step dispensing method, so as to prepare the dehydrogenase-electrochemical biosensor. By adopting the method, the preparation process of the dehydrogenase-electrochemical biosensor is simplified, and the method is suitable for mass production; an inter-batch difference and the difference between batches are reduced; and the detection sensitivity and accuracy and the storage stability are improved.

An apparatus for the delivery of a biological composite and a method, kit, and system for preparing a biological composite is described herein. The biological composite includes both inorganic and biological materials.

A biocomposite is produced from natural fiber fabrics embedded in a matrix of biosynthetic polyhydroxy-alkanoate (PHA) polymers. The PHA is synthesized using aerobic microbial biosynthesis using mixed bacterial cultures and a feedstock containing anaerobic degradation products such as methane and volatile fatty acids derived from microbial biodegradation of organic waste materials, which may include waste biocomposites. Monomers may be added to the synthesized PHA polymer to control mechanical properties of the resulting biocomposite. The natural fibers and/or PHA may be pretreated using various techniques to improve the bond between the fibers and the PHA resin matrix and water absorption resistance of the fibers. The composite may be a laminate of treated and untreated fabric layers, or differently treated layers, to achieve good in-service performance as well as rapid and/or optimal biogas production when taken out of service and put in an anaerobic environment to degrade.

Biocomposite compositions and compositions, which include dried distillers solubles, and which can be used in making biocomposite compositions are described. Methods for preparing the compositions are also described.

The present invention provides a bioactive, small-diameter (typically less than 6 mm in internal diameter) vascular graft prosthesis, and is a textile conduit preferably manufactured using a novel electrospinning perfusion methodology. One preferred embodiment is a nanofibrous biocomposite textile conduit which comprises a prepared liquid admixture of polyester (Dacron), a biodurable implantable synthetic polymer, and Type IV collagen, an extracellular matrix protein. This prepared admixture and blending of diverse fibrous matter is utilized in a novel electrospinning perfusion process to form a small-diameter (less than 6 mm) fabricated textile conduit, a discrete article of manufacture, which then serves as an antecedent tangible workpiece for a subsequently-made prosthetic vascular graft construct. In this manner, after the biocomposite textile conduit has been fabricated as a tangible article, one or more pre-chosen biologically-active compounds are then subsequently permanently bound (covalently or ionically) via a bifunctional linking agent to the wall surface(s) of the textile conduit. These permanently bound compounds retain their characteristic biological activity after becoming permanently immobilized to the textile wall surface; and, via such immobilization, provide the textile conduit wall with many of the highly desired attributes and properties characteristic of naturally occurring blood vessels. Accordingly, after the immobilization of one or more biologically active compounds to the wall surfaces, the completely prepared article is then suitable for use in-vivo as a prosthetic vascular graft construct.

The present invention discloses a method for fabricating aerogels, a method for fabricating surface-modified aerogels, and a method for fabricating biocomposites. Take the fabricating method of biocomposites for example, first, a precursor solution is provided and the precursor solution comprises a hydrophilic ionic liquid, a catalyzed hydrolysis and/or condensation reagent, at least one biomolecule. Next, a curing process is performed for the precursor solution to hydrolyze and polymerize the at least one alkoxide monomer and/or aryloxide monomer to wrap at least one biomolecule and thus form biocomposite. Afterwards, an extracting process is performed by a solvent for the biocomposite to substitute the ionic liquid in the biocomposite. Finally, a drying process for the biocomposite is carried out after the extracting process so as to remove the solvent in the biocomposite. Therefore, the biocomposite is formed.

A preparation method of Bacillus subtilis biological composite material loaded with Fe₃O₄ magnetic nanoparticles with core-shell structure includes the following steps: 1) preparation of Fe₃O₄ nanoparticles, 2) preparation of Fe₃O₄@mSiO₂ nanoparticles, 3) preparation of Fe₃O₄@mSiO₂@MANHE nanoparticles; and 4) preparation of Bacillus subtilis@Fe₃O₄@mSiO₂@MANHE composite.

The invention discloses a material increase manufacturing method of a multi-scale biomimetic artificial bone support. The material increase manufacturing method comprises blending a biopolymer material and a bioceramic material, blending the mixture and deionized water or an organic solvent to obtain uniform slurry, carrying out freeze drying to obtain uniform powder, blending the uniform powder and deionized water or an organic solvent, carrying out vacuum exhaust, carrying out quantitative extrusion by a screw pump, by a XYZ motion device, designing internal aperture shapes, sizes and porosity of a geometric model by computer program according to a bone defect 3D geometric model obtained by CT scanning, and carrying out material increase manufacture under control of an extruded material motion locus. Through use of a degradable biological compound material, human autologous tissue finally replaces bone defect positions so that human lifelong growth requirements are satisfied. The needed biomaterial is quantificationally extruded by the screw pump so that use amount can be accurately controlled and an artificial bone clinical application cost is substantially reduced. The material increase manufacturing method has the advantages of accurate printing material use amount, wide material application range, accurate and controllable aperture structure, and free formation of a macroscopic geometric shape.

The invention relates to a preparing method of a zinc magnesium function gradient biological composite. Magnesium powder, zinc powder and HA powder are adopted to serve as raw materials, ball milling powder mixing, die filling and vacuum discharge plasma sintering are carried out, and a zinc magnesium composite of two gradient structures is prepared. The preparing method is advanced in technology, data are full and accurate, a prepared zinc magnesium gradient material is high in combination strength on the interface, the debinding phenomenon is avoided, wear resistance and mechanical properties(the crush resistance strength is 293.66MPa, the elasticity modulus is 8.0 GPa, and breaking tenacity is 9.327 MPa.mm<1/2>) of all gradient layers are matched with the natural bone, the stress shielding effect is effectively avoided, and the preparing method is an ideal preparing method for a degradable biomedical metal gradient material.

The invention relates to a method for preparing a bacterial cellulose membrane with high rehydration, which comprises the following steps: (1) performing alkaline treatment on bacterial cellulose hydrogel membrane of which bacteria and culture medium are removed; (2) performing etherification treatment on the processed membrane; (3) performing neutralization reaction on the etherified membrane to obtain a bacterial cellulose membrane subjected to hydroxypropylation; and (4) drying the bacterial cellulose membrane subjected to hydroxypropylation to obtain the bacterial cellulose membrane with high rehydration. The method aims at the defect of low rehydration performance of the prior bacterial cellulose membrane, uses a method of hydroxypropylation modification of the bacterial cellulose surface to destroy a part of hydrogen bonds in cellulose; a rehydration rate test finds that the dried bacterial cellulose membrane subjected to hydroxypropylation has high rehydration and reswelling capability; and the bacterial cellulose membrane subjected to hydroxypropylation can be used for preparing biologic composite materials, and has importance significance on biomedical materials and the like.

A medical implant comprising a plurality of layers, each layer comprising a polymer and a plurality of uni-directionally aligned continuous reinforcement fibers.

The invention provides a method for preparing a bionic human bone biomaterial. The method comprises the steps of utilizing a direct laser selective sintering technique to prepare a human bone bionic micropore bracket, injecting a material with the function of inducing bone growth into the bionic micropore bracket, drying and curing the obtained product and obtaining the bionic human bone biomaterial. The method combines the advantages of metal biomaterials and non-metal biological ceramic materials (hydroxyapatite), and utilizes the direct laser selective sintering technique, a vacuum impregnation technique and the like to prepare a novel bionic human bone biological composite material. The material has the advantages of biomechanical properties similar to natural bones, good biocompatibility, capability of realizing the synostosis of implanted bones and human tissue after the material is implanted into human bodies, safety and reliability. The bionic human bone biomaterial prepared by the preparation method has ultimate tensile strength more than 300 MPa, elongation between 10 and 12 percent, tension-compression elastic modulus less than 50 GPa and good biocompatibility.

The invention relates to a method for preparing bionic laminated cartilage/bone element, wherein it comprises preparing porous same heterogenous bone or different bone elements; preparing artificial cartilage and laminated cartilage/bone composite. The invention processes the bone into needed size and shape, to be washed and immunity treatment, to be put at the bottom of mould; then at positive and passive pressures, pouring the polyvinyl alcohol/biological active component preformed element and polyvinyl alcohol/lubricant molecule preformed element into mould; flattening the surface and compressing; freezing and fusing, shaping. The inventive product has surface layer as abrasion-resistant lubricant layer, middle layer as force layer, and bottom layer as biological active cartilage/bone combine layer, to meet biological physica property and physiological function.

The invention discloses a polyether-ether-ketone composite material containing fluorapatite and titanium dioxide and a preparation method thereof, belonging to the technical field of biomedical composite materials. The composite material is a bone restoration material prepared from a polyether-ether-ketone composite material with enhanced fluorapatite and titanium dioxide and is prepared by blending fluorapatite, titanium dioxide and polyether-ether-ketone in a fusion way, wherein the fluorapatite and the titanium dioxide are respectively 10-30 percent of the total weight of the composite material, and the balance is the components of the polyether-ether-ketone. The composite material prepared from the fluorapatite, the titanium dioxide and the polyether-ether-ketone in the invention realizes good strength and toughness and consistent elastic modulus with a human bone, has bone-substitute material with bioactivity, and can overcome the defect that the traditional metal and ceramic bone-substitute material has the mechanical property which is not matched with the human bone.

The invention discloses a hydroxyapatite activated titanium alloy surface-layer biological composite material and its preparation method and belongs to the field of biomedical material preparation. The surface-layer biological composite material is characterized in that titanium alloy is used as a matrix, and hydroxyapatite + titanium is a biological active layer. Technological steps are as follows: respectively carrying out mechanical alloying, ball-milling, powder-blending and drying on the titanium alloy matrix powder and the biological active layer powder, respectively placing the dried matrix mixed powder and the dried biological active layer mixed powder to a lower layer and an upper layer of a graphite mould (as shown in the specification), sintering in a spark plasma sintering furnace, and cooling to room temperature to obtain the surface-layer biological composite material. During the sintering process, axial pressure is 30-40 MPa, sintering temperature is 1100-1250 DEG C, and thermal insulation lasts for 10-15 min. In the prepared surface-layer composite material, the composite layer and the matrix are chemically and metallurgically bonded. The interface bonding strength is high, and the problem that a biological ceramic coating is easy to fall off can be solved. The preparation process is clean. The technology is simple and low-cost, and is easy to realize industrial production.

The invention relates to a preparation method of a biological composite, in particular to a preparation method of chitosan reinforced rod, providing a preparation method of chitosan reinforced rod which has favorable mechanical property and is biodegradable, absorbable and can be taken as bone fracture internal fixation. The preparation method is characterized in that: chitosan powder is added into the acetic acid solution in which poly-lactic acid short fiber is dispersed, the solution is agitated to form a chitosan/acetic acid solution; the chitosan/acetic acid solution is smeared on the inner wall of a mould, the mould is immersed and precipitated into sodium hydroxide solution, and then chitosan membrane taken as a mould board for in situ precipitation is obtained; the mould is filled with the chitosan/acetic acid solution, and then the mould are taken off in the sodium hydroxide solution, while the chitosan/acetic acid solution is immersed into the sodium hydroxide solution until the whole chitosan gel rod is formed; the chitosan gel rod is immersed into distilled water till the water is neutral, and then the rod is dried, at last the poly-lactic acid short fiber reinforced transparent yellowish chitosan rod is obtained.

A Sheet Molding Compound (SMC) as prepregs and cured compositions with naturally derived fibers which have been dried for at least three hours is described. The SMC process combines polyester polymer or resin with the fibers preferably continuously. The molded products are useful for a variety a purposes where glass fiber filled polyester polymers are conventionally used.

The present invention relates to a biocomposite material which comprises biodegradable polylactic acid/glycolic acid copolymer, tricalcium phosphate and effective amount of icaritin. The invention also relates to a preparing method of the biocomposite material and an artificial bone support prepared by the biocomposite material. Furthermore, the invention also relates to the use of the biocomposite material in treating tissue defect, particularly in preparing bone defect.

The present invention concerns a natural biocomposite powder prepared from the biomass of yeast Pichia pastoris, comprising chitin-glucan complex (CGC) and mannose-containing polysaccharides. In a second aspect, the invention concerns the method of preparation of the natural biocomposite powder. The invention also concerns the method to obtain Pichia pastoris biomass with increased CGC content, as well as increased chitin to glucan content in the CGC. Finally, the invention concerns the use of the natural biocomposite powder, prepared from the cell wall of yeast Pichia pastoris by the method according to the invention, as excipient in the pharmaceutical, cosmetics or food industries.

The invention relates to the technical field of biological composite materials, and discloses a preparation method of a novel neural restoration tissue engineering scaffold. The preparation method comprises the following steps: modifying bacterial cellulose; preparing a living cell derived material; uniformly mixing the modified bacterial cellulose with the living cell derived material to obtain a mixture, injecting the mixture into a mold, and preparing the neural restoration tissue engineering scaffold by an ice crystals directional solidification method and a freeze vacuum drying method. The preparation method has the benefits that due to dual bionic design of a structure and a component, the living cell derived material, modified nano fibers and a conductive nano material are combined, so that the obtained scaffold is high in moisture content, good in comprehensive mechanical property and high in stability, and has bioactivity and electroactivity; meanwhile, growth and increment of blood cells can be promoted favorably, and a function of axonal regeneration can be guided; the preparation method is simple, and the shape and the size of a prepared product are easy to control; various requirements of the neural restoration tissue engineering scaffold can be met, and the application prospect is wide.

In general, the present invention is related to biopolymer and biocomposite materials and structures, and methods of making and using the same. In some embodiments, the present invention is directed to oriented collagen based biocomposite materials and structures, and methods of making.

The present invention provides bioerodable constructs for controlled release of bioactive materials. In a preferred mode, the constructs may be utilized adjacent to a biological surface. The constructs are based on a blend of two or more poly(ester-amide) polymers (PEA). Such polymers may be prepared by polymerization of a diol (D), a dicarboxylic acid (C) and an alpha-amino acid (A) through ester and amide links in the form (DACA)_n. An example of a (DACA)_n polymer is shown below in formula II. Suitable amino acids include any natural or synthetic alpha-amino acid, preferably neutral amino acids.