The present invention provides a bioactive, small-
diameter (typically less than 6 mm in internal
diameter)
vascular graft prosthesis, and is a
textile conduit preferably manufactured using a novel
electrospinning perfusion methodology. One preferred embodiment is a nanofibrous
biocomposite textile conduit which comprises a prepared liquid admixture of
polyester (Dacron), a biodurable implantable
synthetic polymer, and
Type IV collagen, an
extracellular matrix
protein. This prepared admixture and blending of diverse fibrous matter is utilized in a novel
electrospinning perfusion process to form a small-
diameter (less than 6 mm) fabricated
textile conduit, a discrete article of manufacture, which then serves as an antecedent tangible workpiece for a subsequently-made prosthetic
vascular graft construct. In this manner, after the
biocomposite textile conduit has been fabricated as a tangible article, one or more pre-chosen biologically-active compounds are then subsequently permanently bound (covalently or ionically) via a
bifunctional linking agent to the wall surface(s) of the textile conduit. These permanently bound compounds retain their characteristic
biological activity after becoming permanently immobilized to the textile wall surface; and, via such immobilization, provide the textile conduit wall with many of the highly desired attributes and properties characteristic of naturally occurring blood vessels. Accordingly, after the immobilization of one or more biologically active compounds to the wall surfaces, the completely prepared article is then suitable for use in-vivo as a prosthetic
vascular graft construct.