683 results about "Bio compatibility" patented technology

The invention relates to compound millimicron fibrous membrane material of cellulose and cellulose matrix which can perform the biological degradation and the biological absorption and a preparation method thereof and an industry and medical purpose, and belongs to the biological macro-molecule non woven fabric material field which can perform the biological degradation and the biological absorption. Electrostatic spinning equipment is used to obtain the fibrous membrane material which can perform the biological degradation and the biological absorption, the weight of the cellulose is taken as basic reference, the component of the material comprises cellulose more than 0 and less than or equal to 100 weight parts, other biomacromolecule more than and equal to 0 and less than 100 weight parts, 0 to 10 weight parts of curative drug or 0 to 50 weight parts of inorganic catalyzer and / or 0 to 50 weight parts of inorganic strengthening agent. The material of the invention has good biological compatibility, biological degradation property and degradation absorptivity, and can be used for haemostasia material, wound cladding material, organization engineering supporting rack material, the transportation and release of medicine, artificial skin and blood vessel, and postoperation anti blocking material, beauty material and catalyzer carrier, filtering membrane and radiation protection material and so on.

A fluorinated resin having enhanced wettability to water prepared by roughening a surface of the fluorinated resin such that a central line roughness average (Ra) of the surface is increased to at least 0.1 mum, and then depositing thereon a thin hydrophilic film while maintaining the central line roughness average (Ra) of at least 0.1 mum, the thin hydrophilic film being formed from a hydrophilic substance having a contact angle of water of less that 90°, and the resulting fluorinated resin having up to 20° of contact angle of water. The fluorinated resins are able to maintain high hydrophilicity even after prolonged exposure to the atmosphere and can be used in various fields that require bio-compatibility and in permeable membranes or filters.

The invention relates to a suture line containing bioactive ingredients and a preparation method thereof. The suture line is prepared by a plurality of superfine fibers with biocompatibility through the coaxial cospinning technology and after-treatment, and the plurality of the superfine fibers are biodegradable materials, wherein at least one superfine fiber is a composite superfine fiber with acore-shell structure; a core comprises the bioactive ingredients; and a shell is a biodegradable material. The suture line containing the bioactive ingredients has the advantages that the suture linecontaining the bioactive ingredients aims to realize wound suture and avoid wound infection caused by secondary operation; the biodegradable materials are taken as substrate materials and as shell layer materials of the coaxial cospinning composite superfine fibers, and different bioactive ingredients are packaged into core layers; and the diameter, the structure and the mechanical property of the suture line and the release property of a medicine and so on are controlled by adjustment of the processing parameters, so that the prepared suture line meets the suture requirements of various different tissues, not only can suture the wound but also can reduce infection, and has the function of treatment.

The present invention discloses a kind of chitosan medical nerve, including chitosan bio-catheter and chitosan fibre scaffold inserted into the chitosan bio-cathether. Its production method includes the preparation of the above-mentioned materials and their combination steps. It is a pure natural bio-degradable material, so that it possesses good bio-compatibility, has no any adverse reaction. Itthe course of preparation is does not add any foaming agent, cross-linking agent and surfactant, therefore said product contains no any exogeneous toxic substances capable of producing said effect.

The invention belongs to the medical material and preparation technology field, and provides a hydrogel antibacterial gauze dressing and a preparation method therefor. Hydrophilic macromolecules and glycerin are dispersed in purified water, mixed and stirred uniformly. After full swelling, inorganic nano-antibacterial agents are added, uniform mixing and stirring are carried out again and a uniform mixture, namely, hydrogel is obtained. Then the obtained hydrogel is painted on a support layer uniformly, and a hydrogel layer is formed. Then protection layers cover the exposed parts of the hydrogel layer and the support layer, and a finished product is obtained. The obtained hydrogel antibacterial gauze dressing has good biological compatibility, wound healing is promoted rapidly, the stability is good, the dressing has no toxic or side effects and the antibacterial effects are obvious.

The invention discloses a method for preparing a polyvinylidene fluoride affinity membrane using amino acid as a ligand. The affinity membrane is prepared by hydrophilically modifying a polyvinylidene fluoride hollow fiber membrane and grafting the amino acid ligand. The grafting amount of the amino acid is 150 to 250mg/g for each membrane. The invention also discloses application of the affinity membrane in removing endotoxin in blood plasma, which removes the endotoxin in the blood plasma by a dynamic absorption means. The polyvinylidene fluoride affinity membrane prepared by the method has stable performance, good bio-compatibility and high endotoxin removing efficiency, and can be used for whole blood perfusion as well as blood plasma perfusion.

Disclosed is a method for production of a bio-derived scaffold for use in regenerative medicine, which has a bio-compatibility and biodegradability and can self-organize and grow without causing calcification. The method comprises the steps of partially fixing a biological soft tissue with glutaraldehyde by cross-linking and incubating the partially fixed tissue together with an elastase.

The invention relates to the field of physiological monitoring sensors and discloses a wearable flexible sensor for monitoring wrist pulse, a preparation method for the wearable flexible sensor for monitoring the wrist pulse, and a monitoring system based on the sensor. The wearable flexible sensor for monitoring the wrist pulse comprises a fabric object, a blocked layer formed on the fabric object and in contact with the wrist pulse region, a sensitive layer formed at the upper surface of the blocked layer, an electrode layer comprising at least two electrodes which lead from the sensitive layer or the surface of the sensitive layer, and a skid-friendly layer, wherein the sensitive layer is made of three-dimensional porous nanometer sensitive material, the skid-friendly layer and the blocked layer are made of high-molecular polymer and have bio-compatibility, and the skid-friendly layer and the blocked layer together package the sensitive layer. The wearable flexible sensor for monitoring the wrist pulse is thin and soft, capable of being processed into different shapes, and capable of being worn on the wrist pulse or attaching to the wrist pulse to monitor the pulse information.

A PDMS valve-less micro pump structure includes a PDMS body having a contour surface, a membrane covering the contour surface of the PDMS body, and a PZT actuator located on the membrane. The contour surface of the PDMS body to be sealed by the membrane and the PZT actuator has in series a lead-in cavity, a lead-in nozzle structure, a main cavity, a lead-out nozzle structure, and a lead-out cavity. The PZT actuator is located right above the main cavity. By providing the PDMS as a material to form the body of the micro pump, the micro pump can then be mass-produced with less cost and simpler structuring. Also, substantial elasticity and bio-compatibility for the micro pump can be achieved.

The invention discloses gelatin/carboxymethyl chitosan/POSS (polyhedral oligomeric silsesquioxane) photo-crosslinking hydrogel and a preparation method. Main components of the hydrogel consist of modified gelatin, modified carboxymethyl chitosan and octavinyl oligomerization silsesquioxane. The preparation method comprises the following steps: executing the double bond modification for the gelatin and the carboxymethyl chitosan by utilizing methacrylic acid glycidyl ester; mixing the modified gelatin, the modified carboxymethyl chitosan, the octavinyl oligomerization silsesquioxane, the cross-linking PEGDMA and the photo initiator 12959 to a solution, and photo-crosslinking the mixture to prepare the hydrogel. The gelatin/carboxymethyl chitosan/POSS photo-crosslinking hydrogel has the advantages that the preparation process is fast and simple, and the prepared hydrogel has biological compatibility; meanwhile, octavinyl oligomerization silsesquioxan is introduced into the system, so that the mechanical property of the gel can be remarkably improved, the biological and mechanical requirements of the repaired tissue can be simultaneously met, and the hydrogel has good application prospect on the aspect for restoring bones and basibranchial bones.

The preparation method of magnetic nano particle with bio-compatibility includes the following steps: heating and decomposing metal organic iron compound in high boiling point polar solvent in the presence of bio-compatibility molecule, precipitating and separating so as to obtain said magnetic nano particles with bio-compatibility. By adopting bio-compatibity molecules containing double-functional group (for example double-functional group polyglycol and its derivative, etc.) to make modification the magnetic nano particles whose surface has different functional groups can be obtained. By adopting different iron materials the nano particles with different types of Fe, gamma-Fe2O3 and Fe3O4 can be obtained.

The invention discloses an oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane and a preparation method thereof. The oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane is characterized in that the preparation method comprises the steps: by applying an electrostatic spinning technology and using traceable purified porcine dermis as a raw material and hexafluoroisopropanol as a solvent, stirring at 4-10 DEG C until the mixture is transparent, formulating to obtain electrostatic spinning mother liquor with concentration of 0.5-10%, and directly spinning to obtain the porcine dermal collagen micro-nano fiber membrane; then performing graft modification on the porcine dermal collagen micro-nano fiber membrane by using oxidation chitosan, thereby finally obtaining the oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane. A membrane material not only has good bio-compatibility, biodegradability and mechanical properties, but also has anti-oxidation effects, antibacterial activities, anti-inflammation/wound healing promotion effects, anti-cancer/anti-tumor effects and antiviral effects of chitosan, is significantly better than a collagen composite membrane material prepared by using collagen as the raw material, and can be widely applied to the preparation of biomedical materials such as hemostatic materials, tissue engineering scaffold materials, biological dressings and the like.

The invention provides an epimedium aglycone liposome. The liposome consists of the following components in percentage by weight: 50 to 85 percent of soya bean lecithin, 10 to 35 percent of cholesterin and 2 to 25 percent of epimedium aglycone; the surface of the liposome is a phospholipid bimolecular layer, and hydrophilic groups on the outer part of the bimolecular layer form a hydrophilic cap; hydrophilic groups on the inner part of the bimolecular layer form an inner water phase, and hydrophobic groups between the bimolecular layer form a hydrophobic region; and the epimedium aglycone is coated between the phospholipid double layer of the liposome, and the absolute value of the Zeta electric potential is more than 40mV after the liposome is hydrated. The epimedium aglycone liposome has the characteristics that: 1, the preparation method is simply and easily implemented, the raw material, namely the soya bean lecithin has good bio-compatibility, and can be biodegradable, and the raw material is also wide in source and low in cost; 2, by utilizing the nanometer technology, the traditional Chinese medicine active ingredient, namely epimedium aglycone is coated between the phospholipid double layer of the liposome, so that the water solubility is improved; and 3, the epimedium aglycone liposome has better physical stability, and after being stood for quite a long time, the epimedium aglycone liposome has no delamination and flocculation. The invention also discloses a method for preparing the epimedium aglycone liposome.

The invention relates to a 3D (Three Dimensional) micro-fluidic structure for cell detection and a preparation method thereof. The entire structure is formed by connecting cover glass, a polydimethylsiloxane (PDMS) fluidic structure and a substrate in a sealing way, wherein a sheath fluid and sample fluid inflow channel (hole), a convergence cavity, a stepped structure and a convergence channel are carved on the PDMS fluidic structure, wherein the stepped structure and the convergence channel are used for realizing 3D focusing; in the convergence cavity, the designed channel shape can realize leftward and rightward focusing of fluid; and in the convergence channel, fluid flows through the stepped structure and is constrained in the vertical direction, so that the 3D focusing can be realized. Meanwhile, the invention provides a process method for preparing the micro-fluidic structure in a twice photoetching and one developing way. By adopting a simple structural scheme, 3D fluid focusing can be realized, and a good application effect and convenience for machining can be achieved; and the PDMS is taken as a structural material, so that low cost and high bio-compatibility are realized.

The invention discloses a method for simultaneously treating multiple kinds of biological tissue. The method includes the steps of pretreating, degreasing, cell extraction, crosslinking and sterilization. The method for simultaneously treating the multiple kinds of biological tissue can simultaneously treat the multiple kinds of biological tissue, the batch-treated biological tissue amount is large, the treatment degree is uniform, the process is simple, industrialization is easy, and efficient production is achieved. According to the method for simultaneously treating the multiple kinds of biological tissue, use of strong acid, strong base and protease is completely avoided, natural three-dimensional collagen support fiber structures of extracellular matrixes of the multiple kinds of biological tissue can be reserved, and cell components, causing immunogenicity, in the tissue are removed. The biological tissue prepared through the method has good bio-compatibility and mechanical performance, compared with natural biological tissue, high degradation resistance is achieved, and the biological tissue can be used for repairing various kinds of soft tissue injuries.

The invention discloses a high-strength, high-plasticity and corrosion-resistant titanium alloy, a preparation method thereof and an application thereof. The invention belongs to the field of titanium alloy technology. According to the titanium alloy, a certain mass fraction proportion of copper (2.6-4.9%) is added into titanium, then the copper and the titanium are mixed and smelted, and after a series of heat treatment processes, dispersed titanium copper phase is precipitated on the basal body of the titanium alloy, so that an anti-microbial objective can be achieved. Moreover, the mechanical property, the corrosion property and the bio-compatibility of the titanium alloy can be improved significantly and the titanium alloy can be widely used for various kinds of titanium alloy medical instruments in the field of medical clinic such as the orthopaedics department, the stomatology department and like.

The invention discloses an ultrasonic coupling agent and application of the ultrasonic coupling agent in ultrasonic inspection or auxiliary treatment of clinical cavity canals, mucous membranes, non-intact skin and the like in hospital. The ultrasonic coupling agent consists of the following raw materials: safe and nontoxic silver ions or nanometer silver serving as a disinfectant, and bio-compatibility macromolecular materials serving as a viscosity regulator, an anti-discoloration agent, an anti-precipitant agent, and an anti-stimulant agent. The ultrasonic coupling agent meets the requirements on ultrasonic impedance and no corrosion, has the characteristics of disinfection, sterilization, safety, nontoxicity, no stimulation and the like, can effectively avoid cross infection in ultrasonic clinics, can be suitable for detecting the cavity canals, the mucous membranes and the non-intact skin, and has high medical clinical value. The ultrasonic coupling agent has a simple preparation method, and low cost of raw materials.

The invention relates to a fluorescent probe for detecting sulfur ions in mitochondria. The fluorescent probe is an RhS fluorescent probe, and the structural general formula of the RhS fluorescent probe is shown in the formula (I). The fluorescent probe can be rapidly positioned in the mitochondria and used for performing online real-time detection on the sulfur ions and hydrogen sulfide ions in the mitochondria. In addition, the probe also has relatively good chemical and optical stability, relatively good solubility and bio-compatibility and relatively high sulfur ion selectivity without interferences caused by other species such as reactive oxygen, reactive nitrogen and the like. Laser confocal imaging experiments show that the probe has relatively good cell permeability without causing toxic or side effects to cells and organisms.

The invention relates to temperature-sensitive nanocapsules and a preparation method thereof. Each prepared temperature-sensitive nanocapsule comprises a core material and a wall material. The preparation method comprises the steps: firstly, separately preparing a water phase and an oil phase, carrying out mixing, then, carrying out high-velocity shearing so as to form a microemulsion, and carrying out an ultrasonic or high-pressure homogenizing action so as to form a nano-emulsion; then, introducing nitrogen gas into the emulsion, and then, carrying out a reaction for 3 to 4 hours at the temperature of 40 DEG C to 80 DEG C in a manner of carrying out a whole process in a nitrogen gas environment, thereby preparing the temperature-sensitive nanocapsules, wherein the encapsulation rate is 90% to 94%, the particle size PDI of the nanocapsules is 0.09 to 0.17, and the particle size is smaller than 150nm. According to the temperature-sensitive nanocapsules and the preparation method thereof, monomers for forming wall materials of the nanocapsules are common biological materials, so that the nanocapsules have good biocompatibility; the formed wall materials of the nanocapsules have temperature sensitivity, the internal core materials can be subjected to controlled sustained release through temperature change, so that the temperature-sensitive nanocapsules have an extensive application prospect in the fields of daily chemical products, textiles and medicines.

The invention discloses a method for preparing a ferrocene functionalized carbon nanotube composite material through thiol-ene click chemistry. The method comprises the following steps: through an acid oxidation modification method, performing carboxyl functionalization on the surface of a multi-walled carbon nanotube; performing sulfydryl modification on the surface through amidation with aminothiol; and selecting an appropriate ferrocene derivative with carbon-carbon double bonds to prepare the ferrocene functionalized carbon nanotube composite material through thiol-ene click chemical reaction. The method is mild in reaction condition and simple and convenient in process; and the prepared ferrocene functionalized carbon nanotube composite material has good dispersion uniformity, stability, conduction reversibility, electric catalytic property and biocompatibility, is low in cost, and can be applied to conductive materials, chemical and biological sensors, biological analysis and other fields as a novel functionalized nanocomposite material.