712 results about "Bio compatibility" patented technology

The invention relates to compound millimicron fibrous membrane material of cellulose and cellulose matrix which can perform the biological degradation and the biological absorption and a preparation method thereof and an industry and medical purpose, and belongs to the biological macro-molecule non woven fabric material field which can perform the biological degradation and the biological absorption. Electrostatic spinning equipment is used to obtain the fibrous membrane material which can perform the biological degradation and the biological absorption, the weight of the cellulose is taken as basic reference, the component of the material comprises cellulose more than 0 and less than or equal to 100 weight parts, other biomacromolecule more than and equal to 0 and less than 100 weight parts, 0 to 10 weight parts of curative drug or 0 to 50 weight parts of inorganic catalyzer and / or 0 to 50 weight parts of inorganic strengthening agent. The material of the invention has good biological compatibility, biological degradation property and degradation absorptivity, and can be used for haemostasia material, wound cladding material, organization engineering supporting rack material, the transportation and release of medicine, artificial skin and blood vessel, and postoperation anti blocking material, beauty material and catalyzer carrier, filtering membrane and radiation protection material and so on.

This invention is concerned with a new method for producing cross-linked hyaluronic acid—protein bio-composites in various shapes. In the present process, a polysaccharide solution and a protein solution are mixed under moderate pH values in presence of salts to form a homogenous solution, which can be processed into various shapes, such as membrane, sponge, fiber, tube or micro-granular and so on. After then, the homogenous solution is subjected to a cross-linking reaction in organic solvent containing weak acid to produce an implantable bio composite material having excellent bio-compatibility, biodegradability, prolonged enzymatic degradation time, and good physical properties.

A method of carrying out an autologous tissue implant in a subject in need thereof is carried out by: (a) forming an autologous tissue implant from autologous cells collected from a subject (e.g., by ink-jet printing, the autologous cells and the scaffold, separately or together), and then (b) implanting the autologous tissue implant in said subject.

Disclosed is a method and a medical device comprising a bio-compatible polymeric product with a layered structure comprising at least one upper layer of a first polymeric component, a middle layer of a second polymeric component, and at least one lower layer of a third polymeric component, wherein the chain length of the first polymeric component and the third polymeric component is longer than the chain length of the second polymeric component. The medical device combines the features of strength, durability and bio-compatibility as well as it has resistance to tear and wear and has a good compressibility. A preferred design of the medical device is a cup produced from a care or film of LDPE surrounded by two layers of UHMWPE fabric. The medical device can be used as implants in mammals, especially as artificial cartilage within joints to secure mobility of the joint.

A fluorinated resin having enhanced wettability to water prepared by roughening a surface of the fluorinated resin such that a central line roughness average (Ra) of the surface is increased to at least 0.1 mum, and then depositing thereon a thin hydrophilic film while maintaining the central line roughness average (Ra) of at least 0.1 mum, the thin hydrophilic film being formed from a hydrophilic substance having a contact angle of water of less that 90°, and the resulting fluorinated resin having up to 20° of contact angle of water. The fluorinated resins are able to maintain high hydrophilicity even after prolonged exposure to the atmosphere and can be used in various fields that require bio-compatibility and in permeable membranes or filters.

The invention relates to a suture line containing bioactive ingredients and a preparation method thereof. The suture line is prepared by a plurality of superfine fibers with biocompatibility through the coaxial cospinning technology and after-treatment, and the plurality of the superfine fibers are biodegradable materials, wherein at least one superfine fiber is a composite superfine fiber with acore-shell structure; a core comprises the bioactive ingredients; and a shell is a biodegradable material. The suture line containing the bioactive ingredients has the advantages that the suture linecontaining the bioactive ingredients aims to realize wound suture and avoid wound infection caused by secondary operation; the biodegradable materials are taken as substrate materials and as shell layer materials of the coaxial cospinning composite superfine fibers, and different bioactive ingredients are packaged into core layers; and the diameter, the structure and the mechanical property of the suture line and the release property of a medicine and so on are controlled by adjustment of the processing parameters, so that the prepared suture line meets the suture requirements of various different tissues, not only can suture the wound but also can reduce infection, and has the function of treatment.

An object of the present invention is to provide a paste-type cement composition which while retaining adhesion to tooth substance, biocompatibility, surface curability and fluorine sustained-releasability which are the characteristics derived from the conventional glass ionomer cement, reduces water sensitivity which is shortcoming of the conventional glass ionomer cement, enables simple mixing operation, does not adversely affect on the various properties of a cured cement depending on a difference in operators or a skill degree, and can afford various stable properties. There is provided a two paste-type glass ionomer cement comprising a resin-based paste containing a hydrophobic polymerizable monomer and a polymer of acidic group-containing polymerizable monomers which are insoluble to each other, and a water-based paste containing a hydrophilic polymerizable monomer and water which are soluble to each other, in which an acid reactive filler is contained in at least one of pastes.

This invention relates to a method for the encapsulation of cells in biologic compatible three dimensional scaffolds and the use of such cells encapsulated in a scaffold. The cells are embedded in a charged polymer that is complex coacervating with an oppositely charged polymer within biologic compatible scaffolds. The polymer complex embedding the cells is forming an ultra thin membrane on the surface of the three dimensional scaffold.

The present invention discloses a kind of chitosan medical nerve, including chitosan bio-catheter and chitosan fibre scaffold inserted into the chitosan bio-cathether. Its production method includes the preparation of the above-mentioned materials and their combination steps. It is a pure natural bio-degradable material, so that it possesses good bio-compatibility, has no any adverse reaction. Itthe course of preparation is does not add any foaming agent, cross-linking agent and surfactant, therefore said product contains no any exogeneous toxic substances capable of producing said effect.

The invention relates to a preparation method of a double-ion type crude oil desalting demulsifier. The preparation method specifically comprises the following steps: (1) carrying out esterification modification on polyethylene glycol monomethyl ether; (2) preparing glycidyl dimethyl alkyl ammonium chloride; (3) preparing quaternary ammonium carboxymethyl chitosan; (4) making the modified polyethylene glycol monomethyl ether react with the quaternary ammonium carboxymethyl chitosan to obtain a polyethylene glycol monomethyl ether grafted quaternary ammonium carboxymethyl chitosan. The double-ion type crude oil desalting demulsifier takes natural macromolecular compounds of chitosan as raw materials, thereby having many advantages of wide sources, naturalness, no toxicity, sustainability, good product bio-compatibility and degradation and the like. The prepared demulsifier is good in demulsification and dehydration effects, furthermore, demulsifier molecules contain a large number of carboxyl alkyl groups and quaternary ammonium salt groups, so that the demulsifier has a very strong binding capacity for negatively charged ions such as metal cations, naphthenic acid radicals and particles of which the surfaces are electronegative, thereby further having the removal ability for oil soluble salts while performing demulsification.

The invention discloses a type of sandwich structure magnetic composite microspheres with functional shells. Said magnetic composite microspheres in structure is characterized by the whole body is as sandwich structure, kernel is as macromolecule microspheres, the middle layer is as magnetic nanoparticles, the external layer is as functional shells of certain thickness.

The invention discloses a biological activity glass meso-porous microsphere and a preparation method thereof. The biological activity glass meso-porous microsphere comprises the following chemical compositions in percentage by weight: 16 to 36 percent of CaO, 4 percent of P2O5 and 60 to 80 percent of SiO; the average grain diameter is between 2 and 5 mu m; the grains are sphere -shaped; the specific surface area of the grains is between 30.6m<2> / g and 89.7m<2> / g; and the meso-porous diameter is between 1.9 and 4.1nm. The method adopts the organic template method, comprising the following the steps that: a catalysts is added in deionized water, the mixed solution is added with tetraethoxysilane, triethyl phosphate and calcium nitrate tetrahydrate for hydrolysis reaction, the mixed solution is added with organic template polyethylene glycol and fully stirred to obtain sol, the sols is subject to aging to form wet gel, the wet gel is immersed in and washed by absolute ethyl alcohol and dried to obtain dry gel, and the dry gel is put in a crucible for heat treatment to obtain the finished products. The biological activity glass meso-porous microsphere has the advantages of higher biological activity and degradation property and good biological compatibility.

The invention provides a modified biopolymer fiber reinforced polylactic acid composite material. Lactic acid is utilized to carried out graft modification on biopolymer fiber by virtue of esterification, so as to obtain modified biopolymer fiber, then the modified biopolymer fiber and polylactic acid are taken as raw materials, banburying is carried out, so as to obtain homogeneous mixture of modified biopolymer fiber and polylactic acid, and then the obtained homogeneous mixture of modified biopolymer fiber and polylactic acid is subject to hot forming in a hot press, and finally cooling and solidifying are carried out, thus obtaining the composite material. The preparation method of the invention has simple operation and high production efficiency, interface combination among components of the prepared composite material is good, the composite material of the invention are greatly improved in mechanical properties and thermal properties compared with polylactic acid, and cost of material is greatly reduced. The composite material of the invention remains good biodegradability and biocompatibility of polylactic acid and can be used for preparing novel environmentally friendly engineering plastics and fracture internal fixation tissue engineering material.

The invention belongs to the medical material and preparation technology field, and provides a hydrogel antibacterial gauze dressing and a preparation method therefor. Hydrophilic macromolecules and glycerin are dispersed in purified water, mixed and stirred uniformly. After full swelling, inorganic nano-antibacterial agents are added, uniform mixing and stirring are carried out again and a uniform mixture, namely, hydrogel is obtained. Then the obtained hydrogel is painted on a support layer uniformly, and a hydrogel layer is formed. Then protection layers cover the exposed parts of the hydrogel layer and the support layer, and a finished product is obtained. The obtained hydrogel antibacterial gauze dressing has good biological compatibility, wound healing is promoted rapidly, the stability is good, the dressing has no toxic or side effects and the antibacterial effects are obvious.

The invention relates to a medical magnesium alloy surface degradable composite protective film layer and a preparation method thereof. The degradable composite protective film is prepared on a medical magnesium alloy surface and has an internal and external bilayer film structure: the internal layer film is prepared by a microarc oxidation technology, a magnesium oxide and magnesium silicate ceramic phase is used as a substrate, and nanometer zirconia particles used for toughening and strengthening and hydroxyapatite particles used for improving bioactivity are dispersed and distributed in the substrate phase; and the external layer film is prepared in a vacuum infiltration method, gelatin is used as a substrate, and hydroxyapatite particles are dispersed and distributed in the gelatin substrate. The composite film layer can obviously improve the corrosion resisting property and toughness of material so as to achieve the purpose of controllable degradation, and simultaneously the composite film layer can improve the biocompatibility of the material.

The invention discloses a method for preparing a polyvinylidene fluoride affinity membrane using amino acid as a ligand. The affinity membrane is prepared by hydrophilically modifying a polyvinylidene fluoride hollow fiber membrane and grafting the amino acid ligand. The grafting amount of the amino acid is 150 to 250mg / g for each membrane. The invention also discloses application of the affinity membrane in removing endotoxin in blood plasma, which removes the endotoxin in the blood plasma by a dynamic absorption means. The polyvinylidene fluoride affinity membrane prepared by the method has stable performance, good bio-compatibility and high endotoxin removing efficiency, and can be used for whole blood perfusion as well as blood plasma perfusion.

Disclosed is a method for production of a bio-derived scaffold for use in regenerative medicine, which has a bio-compatibility and biodegradability and can self-organize and grow without causing calcification. The method comprises the steps of partially fixing a biological soft tissue with glutaraldehyde by cross-linking and incubating the partially fixed tissue together with an elastase.

The invention relates to the field of physiological monitoring sensors and discloses a wearable flexible sensor for monitoring wrist pulse, a preparation method for the wearable flexible sensor for monitoring the wrist pulse, and a monitoring system based on the sensor. The wearable flexible sensor for monitoring the wrist pulse comprises a fabric object, a blocked layer formed on the fabric object and in contact with the wrist pulse region, a sensitive layer formed at the upper surface of the blocked layer, an electrode layer comprising at least two electrodes which lead from the sensitive layer or the surface of the sensitive layer, and a skid-friendly layer, wherein the sensitive layer is made of three-dimensional porous nanometer sensitive material, the skid-friendly layer and the blocked layer are made of high-molecular polymer and have bio-compatibility, and the skid-friendly layer and the blocked layer together package the sensitive layer. The wearable flexible sensor for monitoring the wrist pulse is thin and soft, capable of being processed into different shapes, and capable of being worn on the wrist pulse or attaching to the wrist pulse to monitor the pulse information.

A PDMS valve-less micro pump structure includes a PDMS body having a contour surface, a membrane covering the contour surface of the PDMS body, and a PZT actuator located on the membrane. The contour surface of the PDMS body to be sealed by the membrane and the PZT actuator has in series a lead-in cavity, a lead-in nozzle structure, a main cavity, a lead-out nozzle structure, and a lead-out cavity. The PZT actuator is located right above the main cavity. By providing the PDMS as a material to form the body of the micro pump, the micro pump can then be mass-produced with less cost and simpler structuring. Also, substantial elasticity and bio-compatibility for the micro pump can be achieved.

There is provided an organic-inorganic composite material containing a single nanoparticle therein, which is prepared by individually dispersing hydrophilic inorganic nanoparticles having a uniform particle size and conjugating biodegradable polymers to the surface of the nanoparticle, and a method of preparing the same. More particularly, the preparation method of the present invention comprises the following steps: 1) preparing hydrophilic nanoparticles by conjugating organic substances having a thiol group and a hydrophilic amine group to the surface of a core or a core / shell inorganic nanoparticle protected with a surfactant through a metal-thiolate (M-S) bond between them; 2) adjusting the concentration of the hydrophilic nanoparticles prepared in step 1) to 2×10−6 M or less and treating them in a sonication bath to prepare individually dispersed nanoparticles in the form of a single particle; and 3) conjugating biopolymers to the nanoparticle individually dispersed in step 2) through the formation of an amide bond between them under treatment in a sonication bath. The organic-inorganic composite material of the present invention exhibits high efficient photoluminescence and photostability as well as excellent chemical stability, dispersibility in water, biocompatibility and targetibility. Thus, it can be effectively used as a raw material for bioimaging or film coating.

The invention discloses gelatin / carboxymethyl chitosan / POSS (polyhedral oligomeric silsesquioxane) photo-crosslinking hydrogel and a preparation method. Main components of the hydrogel consist of modified gelatin, modified carboxymethyl chitosan and octavinyl oligomerization silsesquioxane. The preparation method comprises the following steps: executing the double bond modification for the gelatin and the carboxymethyl chitosan by utilizing methacrylic acid glycidyl ester; mixing the modified gelatin, the modified carboxymethyl chitosan, the octavinyl oligomerization silsesquioxane, the cross-linking PEGDMA and the photo initiator 12959 to a solution, and photo-crosslinking the mixture to prepare the hydrogel. The gelatin / carboxymethyl chitosan / POSS photo-crosslinking hydrogel has the advantages that the preparation process is fast and simple, and the prepared hydrogel has biological compatibility; meanwhile, octavinyl oligomerization silsesquioxan is introduced into the system, so that the mechanical property of the gel can be remarkably improved, the biological and mechanical requirements of the repaired tissue can be simultaneously met, and the hydrogel has good application prospect on the aspect for restoring bones and basibranchial bones.

The preparation method includes the following steps: modifying hepatic target compound onto degradable polymer (chitosan, polylysine, glucosan, agar, polyglutamic acid-benzyl ester, polyalanine) with biological compatibility, and adopting ion exchange or ultrasonic emulsification process to obtain the invented nano hepatic target bio-degradable medicine carrier material. The hepatic target nano particle solution has good target performance for liver, the medicine enriched rate in the liver can be up to 75%, and its slowly-released administration can be up to above 15 days.

The preparation method of magnetic nano particle with bio-compatibility includes the following steps: heating and decomposing metal organic iron compound in high boiling point polar solvent in the presence of bio-compatibility molecule, precipitating and separating so as to obtain said magnetic nano particles with bio-compatibility. By adopting bio-compatibity molecules containing double-functional group (for example double-functional group polyglycol and its derivative, etc.) to make modification the magnetic nano particles whose surface has different functional groups can be obtained. By adopting different iron materials the nano particles with different types of Fe, gamma-Fe2O3 and Fe3O4 can be obtained.

The invention discloses an oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane and a preparation method thereof. The oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane is characterized in that the preparation method comprises the steps: by applying an electrostatic spinning technology and using traceable purified porcine dermis as a raw material and hexafluoroisopropanol as a solvent, stirring at 4-10 DEG C until the mixture is transparent, formulating to obtain electrostatic spinning mother liquor with concentration of 0.5-10%, and directly spinning to obtain the porcine dermal collagen micro-nano fiber membrane; then performing graft modification on the porcine dermal collagen micro-nano fiber membrane by using oxidation chitosan, thereby finally obtaining the oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane. A membrane material not only has good bio-compatibility, biodegradability and mechanical properties, but also has anti-oxidation effects, antibacterial activities, anti-inflammation / wound healing promotion effects, anti-cancer / anti-tumor effects and antiviral effects of chitosan, is significantly better than a collagen composite membrane material prepared by using collagen as the raw material, and can be widely applied to the preparation of biomedical materials such as hemostatic materials, tissue engineering scaffold materials, biological dressings and the like.

The invention provides an epimedium aglycone liposome. The liposome consists of the following components in percentage by weight: 50 to 85 percent of soya bean lecithin, 10 to 35 percent of cholesterin and 2 to 25 percent of epimedium aglycone; the surface of the liposome is a phospholipid bimolecular layer, and hydrophilic groups on the outer part of the bimolecular layer form a hydrophilic cap; hydrophilic groups on the inner part of the bimolecular layer form an inner water phase, and hydrophobic groups between the bimolecular layer form a hydrophobic region; and the epimedium aglycone is coated between the phospholipid double layer of the liposome, and the absolute value of the Zeta electric potential is more than 40mV after the liposome is hydrated. The epimedium aglycone liposome has the characteristics that: 1, the preparation method is simply and easily implemented, the raw material, namely the soya bean lecithin has good bio-compatibility, and can be biodegradable, and the raw material is also wide in source and low in cost; 2, by utilizing the nanometer technology, the traditional Chinese medicine active ingredient, namely epimedium aglycone is coated between the phospholipid double layer of the liposome, so that the water solubility is improved; and 3, the epimedium aglycone liposome has better physical stability, and after being stood for quite a long time, the epimedium aglycone liposome has no delamination and flocculation. The invention also discloses a method for preparing the epimedium aglycone liposome.

The invention relates to the physiological monitoring field and discloses a wearable physiological sign detection sensor, a preparation method for the wearable physiological sign detection sensor and a monitoring system based on the wearable physiological sign detection sensor. The wearable physiological sign detection sensor is used for monitoring heart rate and respiratory rate. The wearable physiological sign detection sensor comprises a fabric object, a support layer, a sensitive material layer, an electrode layer and a protection layer, wherein the sensitive material layer is made of three-dimensional porous nanometer sensitive material, the protection layer and the support layer are made of flexible high-molecular polymer and have bio-compatibility, and the protection layer and the support layer together package the sensitive material layer. The wearable physiological sign detection sensor is light, thin and soft; the wearable physiological sign detection sensor can be processed into different shapes, and the wearable physiological sign detection sensor can attach to the skin surface or be worn at the skin surface; the wearable physiological sign detection sensor is capable of gathering the chest heart rate and respiratory rate data through integrating on the fabric in contact with the heartbeat region of the chest so as to effectively monitor the heartbeat information.

The invention relates to a 3D (Three Dimensional) micro-fluidic structure for cell detection and a preparation method thereof. The entire structure is formed by connecting cover glass, a polydimethylsiloxane (PDMS) fluidic structure and a substrate in a sealing way, wherein a sheath fluid and sample fluid inflow channel (hole), a convergence cavity, a stepped structure and a convergence channel are carved on the PDMS fluidic structure, wherein the stepped structure and the convergence channel are used for realizing 3D focusing; in the convergence cavity, the designed channel shape can realize leftward and rightward focusing of fluid; and in the convergence channel, fluid flows through the stepped structure and is constrained in the vertical direction, so that the 3D focusing can be realized. Meanwhile, the invention provides a process method for preparing the micro-fluidic structure in a twice photoetching and one developing way. By adopting a simple structural scheme, 3D fluid focusing can be realized, and a good application effect and convenience for machining can be achieved; and the PDMS is taken as a structural material, so that low cost and high bio-compatibility are realized.

The present invention relates to a method for making brush fibre by using natural high-molecular material silk as raw material, said method includes the following steps: boiling silk, adhesive bonding boiled silk to obtain core thread, covering it with silk protein as covering layer, drying, high-pressure steaming or soaking in alcohol to make hardening and insoluble treatment and make silk fibrehave a certain hardness. Said silk protein has no toxicity for human body, has no irritating action and has good bio-compatibility, so that said silk fiber is suitable for making toothbrush and otherbrushes which can be directly contacted with human body.

The invention relates to a preparation method of hydroxyapatite / zirconium dioxide biological ceramic composite material which comprises preparing zirconium dioxide super fine, then preparing hydroxyapatite powder, and loading zirconium dioxide super fine and hydroxyapatite powder into die casting arrangement, pressurizing to obtain blanks, then placing into high temperature furnace for burning. The preparing material has good biocompatibility and high strength and tenacity.

The invention discloses a method for simultaneously treating multiple kinds of biological tissue. The method includes the steps of pretreating, degreasing, cell extraction, crosslinking and sterilization. The method for simultaneously treating the multiple kinds of biological tissue can simultaneously treat the multiple kinds of biological tissue, the batch-treated biological tissue amount is large, the treatment degree is uniform, the process is simple, industrialization is easy, and efficient production is achieved. According to the method for simultaneously treating the multiple kinds of biological tissue, use of strong acid, strong base and protease is completely avoided, natural three-dimensional collagen support fiber structures of extracellular matrixes of the multiple kinds of biological tissue can be reserved, and cell components, causing immunogenicity, in the tissue are removed. The biological tissue prepared through the method has good bio-compatibility and mechanical performance, compared with natural biological tissue, high degradation resistance is achieved, and the biological tissue can be used for repairing various kinds of soft tissue injuries.