110 results about "Bio compatibility" patented technology

The invention belongs to the technical field of adhesives, and particularly relates to a preparation method of a polysaccharide-based reversible bonding adhesive for constructing a dynamic covalent bond network. The preparation method comprises the following steps: by taking lipoic acid and sodium alginate as reactants and ferric chloride as a cross-linking agent, carrying out cross-linking reaction under a stirring condition to obtain a lipoic acid adhesive, namely the polysaccharide-based reversible bonding adhesive. According to the invention, renewable biomass resources such as sodium alginate, hyaluronic acid, chitosan and the like are used as main raw materials, so that the adhesive is expected to replace a traditional synthetic adhesive depending on a petroleum base, accords with a sustainable development strategy, contributes to reducing consumption of fossil resources, avoids release of toxic substances such as formaldehyde and the like in the synthesis and use processes, and has a good application prospect. And the method is more environment-friendly. The bio-based polysaccharide raw material has good biocompatibility and degradability, and an ideal base material is provided for developing a green and safe biomedical adhesive.

Disclosed in the present invention are a gel having a regulatable free water content and morphology, a preparation method therefor, and the use thereof. The method comprises: S1, preparing a solution A from a natural polymer material; S2, mixing a small molecule material containing a positively charged polar group with the solution A to obtain a composite solution B; S3, mixing the composite solution B with a regulator to obtain a composite solution C, stirring same, then adding a condensing agent to the reaction system, and carrying out a curing crosslinking reaction; and S4, removing the regulator and the condensing agent to obtain the gel. By adjusting the concentrations of the natural polymer material and the regulator, gels having different morphologies can be prepared; the gel undergoes a physical process to remove hydrogen bond interaction between the gel and free water, so that the content of free water attached to the surface of the gel can be regulated, thereby regulating the physical and chemical properties of the gel. The gel of the present invention has regulatable morphology and controllable elastic modulus, and has many advantages such as good lubrication effect, good biocompatibility and biodegradability, capability of being biologically active, and capabilities of stimulating cell growth and accelerating wound repair.

The invention relates to self-curing keratin 3D printing ink integrated with shear activation microcapsules and a preparation method of the self-curing keratin 3D printing ink, and belongs to the technical field of biological 3D printing and intelligent materials.The preparation method comprises the steps that high-molecular-weight soluble keratin powder is dissolved in a biocompatible water-based medium with the pH being 6.5-8.5, and after even mixing and defoaming are conducted, a keratin base solution is obtained; wrapping the core material in a corresponding shell to obtain a microcapsule with the average particle size of 1-10 microns; under the stirring condition, the microcapsules are evenly dispersed into a keratin base solution at the temperature of 0-8 DEG C until a uniform suspension system is formed, and the self-curing keratin 3D printing ink integrating the shear activation microcapsules is obtained. And the curing process of the ink is internalized in the printing behavior, so that the printing process is simplified, and the equipment cost and the operation difficulty are reduced. The cross-linking agent is effectively isolated, so that the ink can be stably stored for several weeks before printing without gelling, and the problem that double-component ink must be immediately used after being mixed is solved.

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

This invention discloses a Zn-based framework material, Bi-Cur@Zn-MOF, its preparation method, and its applications in antibacterial and antioxidant properties, belonging to the field of functional materials and biomedical technology. The method specifically involves: dissolving zinc salt in water to obtain a zinc salt solution; dissolving curcumin and biotin together in water to obtain a mixed solution, and adjusting the pH of the mixed solution; mixing and stirring the zinc salt solution and the mixed solution evenly to obtain a precursor solution; subjecting the precursor solution to a hydrothermal reaction; after the reaction, performing solid-liquid separation and collecting the solid; washing and vacuum drying the solid to obtain the Zn-based framework material, Bi-Cur@Zn-MOF. The preparation method of this invention is green and simple, requiring no toxic reagents, and is suitable for large-scale preparation. The Bi-Cur@Zn-MOF prepared by this invention possesses both antibacterial and antioxidant functions, exhibits structural stability and good biocompatibility, and can be used to prepare medical dressings, food packaging materials, skin care products, wound repair, and antioxidant and antibacterial coatings, etc.

A method of preparing an injectable or oral storage stable formulation, comprising: contacting a biological species with a delivery system comprising biocompatible solid particles to form a complex; then optionally, lyophilising the complex to form a powder, and then dispersing the complex in a biodegradable gel material to form the formulation, comprising the complex embedded in the biodegradable gel material. Also related products, methods, and medical uses.

The application relates to the technical field of drug delivery, and discloses a polymer microcrystal patch fused with a biodegradable material and a preparation method thereof, which comprises a microneedle array and a supporting substrate made of raw materials, and is characterized in that the microneedle array is made of raw materials containing a cationic polymer, an anionic polymer, an ion shielding agent and an active ingredient. The preparation method comprises the following steps: filling a solution containing a cationic polymer and an active ingredient into a microneedle negative mold; and covering the surface of the solution with a layer of a solution containing an anionic polymer and an ion shielding agent. By introducing the ion shielding agent, the application effectively controls the ion crosslinking rate between the polymers, solves the problem of incomplete microneedle forming caused by too fast reaction, and significantly improves the forming quality of the microneedles. The method is carried out at room temperature, the conditions are mild, the bioactivity of the active ingredient can be effectively protected, and the used materials are good in biocompatibility and high in safety.

The invention discloses selective laser melting biological ceramic powder for dental restoration and a preparation method thereof, and belongs to the technical field of dental restoration materials. The composite ceramic material comprises the following raw materials in parts by weight: 50-100 parts of composite ceramic powder and 0.1-2 parts of an absorbent, the composite ceramic powder comprises at least two of Al2O3, ZrO2, SiO2 and TiO2; the absorbent comprises any one of TiC, SiC, ZrC, TiN and graphite; the fluidity of the selective laser melting biological ceramic powder for dental restoration is 39-40 s / 50 g. According to the invention, the SLM process adaptability of the material is obviously improved, the inherent biocompatibility, mechanical strength and stability of biological ceramics are considered, and the technical barrier that traditional biological ceramic powder is difficult to be directly used for selective laser melting is overcome; and a feasible material solution is provided for direct additive manufacturing of personalized dental prostheses with high performance and complex structures.

The invention belongs to the technical field of polymer materials, and particularly relates to a poly (p-dioxanone) modified composite material as well as a preparation method and application thereof. The invention provides a poly (p-dioxanone) / polyurethane composite material. The composite material is prepared by melting, blending and processing poly (p-dioxanone) and a polyurethane material. Experiments show that the poly (p-dioxanone) / polyurethane composite material prepared by the invention has excellent mechanical properties, and especially, epsilon t is obviously improved; in addition, the poly (p-dioxanone) / polyurethane composite material also has good thermal stability and improved processability. The invention provides a polymer material modification scheme with high cost effectiveness and good biocompatibility, and the polymer material is expected to be used for biomedical materials and has good application prospects.

The invention discloses a biological material with an efficient peculiar smell removal function, which is prepared from the following raw material components in parts by mass: 8 to 12 parts of manganese precursor, 0.8 to 1.2 parts of soluble metal salt, 4000 to 5000 parts of dispersing agent and 90 to 100 parts of conditioning agent. The composite nano material which takes small-particle-size thorn convex manganese dioxide as a core and loads metal ions is prepared by simple processes such as mixing, reaction, centrifugation and the like. The material can efficiently remove bad breath through a dual synergistic mechanism; small-particle-size manganese dioxide captures odor-producing bacteria through physical adsorption; meanwhile, released metal ions and hydrogen sulfide are subjected to chemical reaction to generate substances difficult to volatilize. Through the synergistic effect of physical interception and chemical conversion, the dual effects of blocking generation of peculiar smell from the source and immediately eliminating the peculiar smell are achieved. The product disclosed by the invention has biocompatibility and a long-acting peculiar smell removal function, can be widely applied to oral care products such as toothpaste and mouth wash, and provides an innovative solution for solving the problem of bad breath.

The application discloses a 3D-printed hydrogel support and a preparation method thereof, relates to the technical field of hydrogel materials, and aims to improve the antibacterial property and biocompatibility of the hydrogel material by modifying the raw material. The application first uses gelatin as the raw material, and processes the gelatin to increase the content of surface amino groups, so that the subsequent reaction is facilitated; then, the application also uses 2,5-thiophene dicarboxylic acid as the raw material, and controls the reaction conditions to react the 2,5-thiophene dicarboxylic acid with 2-aminobenzimidazole, so as to generate an antibacterial intermediate containing a free carboxyl group, a thiophene ring and an imidazole ring structure; the antibacterial intermediate is combined in the gelatin chain segment in the form of an amide bond, then under the action of a photoinitiator, the amide bond is broken to generate an acyl radical, and the acyl radical is further coupled and grafted with an acrylic ester double bond, so as to form a hydrogel cross-linking structure, and the hydrogel material is provided with sufficient compressive strength.

The invention discloses a honeycomb-shaped rigid-flexible two-phase particle and an application of the honeycomb-shaped rigid-flexible two-phase particle in photocuring 3d printing resin. The honeycomb rigid-flexible two-phase particle comprises a flexible polyurethane phase and a rigid silicon oxide phase. A preparation step S1 of preparing an emulsion containing polyurethane particles as a seed emulsion (emulsion A); s2, preparing an emulsion (emulsion B) containing a silicon oxide precursor and an initiator; s3, adding the emulsion B into the emulsion A, and uniformly mixing to obtain a mixed solution; and S4, under the dynamic action and the anaerobic condition, heating the mixed solution to 60-80 DEG C, and reacting for 20-24 hours to obtain the emulsion containing the honeycomb-shaped rigid-flexible two-phase particles. The emulsion containing the honeycomb-shaped rigid-flexible two-phase particles is added into the degradable polymer material with the photocuring property, so that the toughness and the strength of the polymer material can be improved at the same time, and the photocuring property and the biocompatibility of the polymer are not influenced; the material is suitable for being used as a filler to be added to various molded products prepared by high-precision photocuring 3d printing.

The application provides a method for constructing a double-signal sensing platform based on a non-copper nanometer enzyme AuPt@PBA@L-Pd and application, and a multifunctional nanometer composite material AuPt@L-Pd@PBA (hereinafter referred to as APL) with the effects of an oxidase-like enzyme, a peroxidase-like enzyme and a laccase-like enzyme is prepared. The composite nanometer enzyme has a regular cubic morphology, takes PBA as a base material, loads L-Pd through an amide bond, simultaneously collects the advantages of the MOF material PBA and L-Pd, has multiple enzyme-like effects, and can catalyze different chromogenic substrates. The AuNPs and PtNPs on the surface of APL not only provide good binding sites for antibodies, but also successfully prepare a biological composite probe Ab2@APL, further amplify the sensing signal, and improve the sensitivity of the sensing platform. It is worth mentioning that APL has the effect of a laccase-like enzyme, but does not contain copper ions, and further improves the biocompatibility. Based on the high catalytic activity and multifunctional nanometer enzyme Ab2@APL, a multi-signal sensing platform can be constructed, and the application prospect in more fields is wider.

The present invention relates to a process for volumetric printing of a shaped body comprising locally polymerizing a starting material comprising a bio-co-initiator.

The application relates to high-strength anti-fouling ceramics and a preparation process thereof, and belongs to the technical field of ceramic preparation. The ceramics are prepared through raw material preparation, molding, first surface anti-fouling treatment, second surface anti-fouling treatment and quality testing. Carbon fiber balls are added in the reinforced ceramic layer, the strength of the ceramics is effectively improved, the anti-fouling glaze layer is prepared by adopting a double-layer anti-fouling treatment process, in the first treatment, polydopamine and bentonite are used as raw materials of the anti-fouling glaze layer, the anti-fouling modification is realized through good biocompatibility and adhesion, the anti-fouling material can be effectively attached to the ceramic surface to form an anti-fouling material, in the second treatment, the anti-fouling agent is added to further form an anti-fouling protective layer, the combination of the two can effectively guarantee the anti-fouling capacity of the ceramics. The application has high strength, strong anti-fouling capacity, high safety and high application value.

The present disclosure relates to a polymer film of a biosensor including a base layer formed of a first polymer, a bonding layer formed on the base layer, and an outer layer formed on the bonding layer, the base layer being formed of a first polymer, the bonding layer being formed of a second polymer, and the outer layer being formed of a third polymer, the first polymer being a homopolymer having a benzene ring or a heterocycle, the second polymer being a copolymer formed of a first monomer identical to a monomer of the first polymer and a second monomer identical to a monomer of the third polymer, wherein a mass ratio of the first monomer to the second monomer is 3:7 to 7:3, the second polymer being a water-swellable copolymer, the bonding layer having a diffusion control property, and the bonding layer being bonded to the base layer and the outer layer by at least one of a conjugation effect, a like dissolves like, a hydrogen bond interaction, and cross-linking. Thus, it is possible to provide a polymer film of a biosensor capable of expanding a response linear range and having biocompatibility.

The application discloses an antibacterial hemostatic composite material and a preparation method thereof. The application adopts polylactic acid glycolic acid which is degradable and has good compatibility, and grafts hydrophilic N-vinyl-2-pyrrolidone, simultaneously utilizes radiation polymerization to form polypyrrolidone, and reacts with iodine to form high polyiodine with strong antibacterial property, and uses the same as an electrospinning base material and combines with notoginseng element, so that the positively charged amino groups on the notoginseng element and the negatively charged high polyiodine ions form a stable structure, the electrospinning solvent phase separation of the base material is regulated, a porous rapid hemostatic fiber material with uniform notoginseng element distribution and high loading capacity is formed, and the material is endowed with antibacterial property, good biocompatibility and notoginseng element stable release performance.

The invention provides a preparation process of a bioactive ceramic coating for false tooth repair. The preparation process comprises the following steps: S1, selecting a bioactive ceramic raw material and detecting the purity of the bioactive ceramic raw material; s2, calculating the ratio of the bioactive ceramic raw materials and mixing; s3, pretreatment of a denture base; s4, spraying preparation of a bioactive ceramic coating; s5, curing treatment of the bioactive ceramic coating; s6, detecting the performance of the bioactive ceramic coating and judging the quality of the bioactive ceramic coating. According to the method, through multi-step data linkage and algorithm cooperation (S2 double algorithms and S4 double algorithms), the coating performance is converted from'experience control 'to'accurate calculation', the problems of insufficient coating biocompatibility, large mechanical property fluctuation, poor thickness uniformity and the like in a traditional process are solved, accurate parameter regulation and control are achieved, and the method is suitable for large-scale popularization and application. The preparation quality of different batches and different types of false tooth coatings is kept stable, and the large-scale production requirement is met.

The invention relates to the technical field of precious metal composite materials, and discloses a composite material with a core-shell structure nanometer material loaded with precious metal nanometer enzyme and a preparation method and application thereof.The preparation method of the material comprises the steps that Au NPs is prepared, specifically, pure water is kept at 100 DEG C for backflow, chloroauric acid is added, sodium citrate is added after boiling is conducted again, and after the reaction is completed, Au NPs is obtained; cooling, centrifuging, washing and resuspending; au NPs modification: dispersing Au NPs in a stabilizer solution, stirring for reaction, centrifugally washing, and resuspending; the preparation method comprises the following steps: adding ammonia water into an Au-coated SiO2: Au ethanol solution, adding TEOS (Tetraethyl Orthosilicate) in a water bath at 30 DEG C for reaction, centrifugally washing, and Preparing Au-coated SiO2-COOH: adjusting the pH value of the Au-coated SiO2 solution, then adding a carboxyl ethyl silanetriol sodium salt solution for reaction, and carrying out centrifugal washing to obtain Au-coated SiO2-COOH; the preparation method comprises the following steps: preparing Au-coated SiO2-COOH-coated NMN: carrying out ultrasonic treatment on Au-coated SiO2-COOH dispersion liquid, adding a noble metal precursor solution, carrying out ice-water bath, adding NaBH4, carrying out a reaction, carrying out centrifugal washing, and re-suspending in pure water to obtain the Au-coated SiO2-COOH-coated NMN. The composite material disclosed by the invention has good chemical stability and good biocompatibility in a complex environment, and can lay a foundation for application in the fields of in-vitro diagnosis, biological catalysis and the like.

The invention discloses a PEEK composite material with biocompatibility and a preparation method thereof, and belongs to the technical field of PEEK composite materials. The PEEK composite material is prepared from the following raw materials in parts by mass: 100 parts of sulfonated polyether ether ketone, 20 to 40 parts of furan heterocyclic polyarylethersulfone ketone and 5 to 15 parts of Ti3C2TX-SF modified carbon fibers, the furan heterocyclic polyarylether sulphone ketone is a product synthesized through a reaction of 6-(4-hydroxy-3-methoxyphenyl) pyridazine-3 (2H)-ketone, 4, 4 '-difluorodiphenyl sulfone and furyl difluorodiphenyl ketone. The Ti3C2TX-SF modified carbon fiber is obtained by dipping a polydopamine modified carbon fiber in a silk fibroin modified Ti3C2TX material dispersion liquid for surface modification treatment. According to the antibacterial PEEK composite material disclosed by the invention, sulfonated polyetheretherketone is taken as a matrix, and furan heterocyclic polyarylethersulfone ketone and Ti3C2TX-SF modified carbon fibers are added, so that the PEEK composite material has excellent antibacterial performance.

The present disclosure relates to a method for producing a polymer film layer for a biosensor, including: preparing a base layer reagent including a first type of polymer, a bonding layer reagent including a second type of polymer, and an outer layer reagent including a third type of polymer, the second type of polymer being a copolymer formed from a first monomer identical to a monomer of the first type of polymer and a second monomer identical to a monomer of the third type of polymer; and sequentially forming the base layer, a bonding layer having a bonding effect on the base layer, and an outer layer having biocompatibility on the bonding layer, wherein the bonding layer has diffusion control properties in the polymer film layer, and the bonding layer is bonded to the base layer and the outer layer by at least one of a conjugation effect, a like dissolves like effect, a hydrogen bond interaction, and cross-linking. Thus, a method for producing a polymer film layer for a biosensor having biocompatibility and capable of expanding a response linear range can be provided.

The invention relates to a pharmaceutical composition comprising: a. 20-75 wt% of a biodegradable polymer according to Formula (1) POZx, y –(B-R)z (1), wherein POZx, y is a polyoxazoline, B = a hydrophobic moiety, R = H, or a C1-C18 alkylgroup, x = the number of chain ends of the POZx, y, and is 2, 3, 4, 5 or 6, y = the number of attachment points for B-R at each chain end of the POZx, y, and is 1 or 2, and z is the number of (B-R) groups per biodegradable polymer, and is 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12; b. 20-79 wt% of a biocompatible organic solvent; and c. 1-40 wt% of an active pharmaceutical ingredient; wherein the weight percentages of (a), (b) and (c) are defined relative to the sum of (a)+(b)+(c); wherein the weight fraction of the POZx, y ranges between 4-40 wt% relative to the total weight of the biodegradable polymer, wherein the weight fraction of the POZx, y is determined by 1H-NMR. The invention also relates to a biodegradable polymer, and to pharmaceutical compositions comprising the biodegradable polymer and an active pharmaceutical ingredient, wherein the pharmaceutical compositions are in the form of microparticles, microgranules, microspheres or an implant.

The invention pertains to a composite material, comprising a plurality of compatible glass fibers in a thermoplastic polymer matrix, wherein the glass fibers and the polymer matrix are biocompatible and resorbable. The invention further pertains to a method for obtaining a solid polymer composite material comprising a plurality of biocompatible and resorbable glass fibers, which are embedded in a biocompatible and resorbable matrix polymer, wherein the matrix polymer is applied from solution and the solvent of said solution is at least partially removed using an anti-solvent.

The invention provides a lithium disilicate-fluorapatite composite bioglass ceramic as well as a preparation method and application thereof, and the lithium disilicate-fluorapatite composite bioglass ceramic comprises the following components in percentage by total mass of the bioglass ceramic: 26 to 67.7 percent of SiO2, 12.6 to 13.9 percent of Li2O, 3.0 to 5.0 percent of P2O5, 1.5 to 3.5 percent of CaO, 3.0 to 6.0 percent of NaF and 1.0 to 2.0 percent of 8YSZ. The method comprises the following steps: (1) taking lithium carbonate, aluminum oxide, calcium oxide, boric acid, potassium carbonate, lanthanum trioxide and SiO2 as raw materials, mixing the raw materials with a nucleating agent and CeO2, and grinding to obtain basic glass powder; (2) carrying out high-temperature melting on the basic glass powder for 40-60 minutes, and carrying out heat preservation; (3) continuously melting the molten glass at high temperature, and pouring and molding the molten glass to obtain a transparent glass body; and (4) heating the transparent glass body to 800-840 DEG C, and cooling to obtain the lithium disilicate-fluorapatite composite biological glass ceramic. The composite bioglass ceramic provided by the invention has good biocompatibility and excellent mechanical properties, and the preparation method can improve the reliability and service life of the prosthesis.

This invention discloses a high-temperature resistant non-stick coating and its preparation method, comprising a high-temperature resistant substrate composed of bio-based materials, a wear-resistant intermediate layer containing nano-reinforcing phases, and a super-slippery, non-toxic surface layer, with each layer cross-linked by chemical bonds to form a whole. The high-temperature resistant substrate is composed of a composite of nano-hydroxyapatite (n-HAP) and silica aerogel, and a silane-modified natural silk fibroin binder. The n-HAP has a particle size of 50-200 nm and accounts for 30-50% of the total substrate mass. The silica aerogel has a porosity ≥80%, and the silane-modified silk fibroin has a grafting rate of 15-25%. In this invention, the nano-hydroxyapatite and silica aerogel composite is used as the substrate; the former has a decomposition temperature exceeding 1200℃, and the latter has a porosity ≥80%, constructing a highly efficient thermal insulation framework. At 1000℃, the coating mass loss rate is ≤3%, far superior to traditional coatings. The high-temperature resistant substrate uses bio-based materials; the nano-hydroxyapatite has good biocompatibility, and the silane-modified silk fibroin is biodegradable.

The invention belongs to the technical field of food packaging materials, and particularly relates to a radiation refrigeration composite film as well as a preparation method and application thereof in food preservation. Chitosan and micro / nano-sized spherical silicon dioxide are uniformly mixed at room temperature through a one-pot method to form a composite solution, and the composite solution is evaporated to prepare the multifunctional radiation refrigeration composite film with high reflectivity, high emissivity, good hydrophobicity, cooling performance, antibacterial property, antioxidant property and biocompatibility. The preservative is used for food preservation, such as fruits, seafood, meat and the like. The composite film can prolong the shelf life of food under direct solar radiation or at 25 / 4 DEG C. The radiation refrigeration composite film is simple in preparation method, easily available in raw materials and low in cost.

The invention discloses photoresponsive protein hydrogel with wide-area mechanical regulation characteristics. The photoresponsive protein hydrogel is formed by polymerizing a specific mutant of photoactivated xanthoprotein (PYP) and a multi-arm polyethylene glycol derivative with the tail end modified with a maleimide group. Through rational design of molecular dynamics and material mechanics, cysteine mutation is carried out on the 48th site and the 85th site of a wild type PYP sequence, and the PYP (48 / 85) double mutant with an anisotropic unfolding energy scene is constructed. According to the mutant, exposed sulfydryl and a multi-arm polyethylene glycol derivative are subjected to Michael addition reaction to form a cross-linked network. Compared with the prior art (such as PYP 36 / 128 hydrogel), the method has the advantages that higher mechanical sensitivity and unfolding probability of PYP 48 / 85 under network tension are utilized, the limitation that traditional design only depends on chain length change is overcome, and remarkably larger macroscopic rigidity adjusting amplitude (the mechanical switch ratio can reach 70% or above) is achieved. The material has the characteristics of good biocompatibility, high response speed (millisecond level), complete reversibility and wide rigidity dynamic range, and can meet the biological application requirements of stem cell differentiation, tissue fibrosis model construction and the like with high requirements on a mechanical signal threshold.

The present invention relates to a biodegradable coating composition, a method for preparing the same, and a biodegradable article using the same. In particular, according to an embodiment of the present invention, the biodegradable coating composition is a copolymer polyhydroxyalkanoate (PHA) resin including a PHA resin, a surfactant, inorganic particles, and a rheology modifier, and includes 4-hydroxybutyrate (4-HB) repeating units. By using a PHA resin having a weight average molecular weight of 10,000 g / mol to 12,000,000 g / mol, the biodegradable coating composition is environmentally friendly due to excellent biodegradability and biocompatibility, and can have improved dispersibility, coating properties, oil resistance, and processability.

The invention discloses a modified mesoporous silica material, a preparation method thereof and application of the modified mesoporous silica material as a multifunctional nano-drug carrier material. According to the carrier material, through synergistic modification of a silane coupling agent AEPTMS, triethanolamine and 1, 3, 5-benzene triamyl alcohol, an organic-inorganic hybrid interface structure is constructed on the surface of mesoporous silica. Through unique long-chain and short-chain collaborative design, a hydrophobic drug storage micro-area and a stable cross-linked network are constructed in mesopores, and the high drug loading capacity and the pH response release characteristic of the carrier are achieved. The carrier material can intelligently adjust the release behavior in an acid environment, and has excellent biocompatibility and structural stability. The technology solves the problems of low drug loading efficiency, inaccurate release control and the like of a traditional carrier, and provides a new solution for a targeted drug delivery system.

The invention relates to a polyvinyl alcohol-based photo-thermal-contact integrated antibacterial film and a preparation method and application thereof, and belongs to the technical field of antibacterial materials.The method comprises the steps that silver nitrate and quercetin are dissolved according to the mass ratio of (0.28-0.6): (0.85-1.73), the pH is adjusted to be 7-7.3, then heat preservation treatment is conducted, precipitates in obtained reaction liquid are washed and dried, and quercetin-silver nanoparticles are obtained; the preparation method comprises the following steps: freezing a polyvinyl alcohol dispersion liquid of quercetin-silver nanoparticles, adding a polyvinyl alcohol dispersion liquid of MXene to continue freezing when a block is formed, freeze-drying the obtained frozen block to obtain a double-layer aerogel block, and carrying out hot pressing on the double-layer aerogel block to obtain the quercetin-silver nanoparticle / MXene double-layer aerogel composite material with the mass ratio of the quercetin-silver nanoparticles to the MXene of (10-120): (10-150). The polyvinyl alcohol-based photo-thermal-contact integrated antibacterial film is obtained, and good biocompatibility and excellent antibacterial performance are achieved.