171 results about "Bio compatibility" patented technology

The invention belongs to the technical field of adhesives, and particularly relates to a preparation method of a polysaccharide-based reversible bonding adhesive for constructing a dynamic covalent bond network. The preparation method comprises the following steps: by taking lipoic acid and sodium alginate as reactants and ferric chloride as a cross-linking agent, carrying out cross-linking reaction under a stirring condition to obtain a lipoic acid adhesive, namely the polysaccharide-based reversible bonding adhesive. According to the invention, renewable biomass resources such as sodium alginate, hyaluronic acid, chitosan and the like are used as main raw materials, so that the adhesive is expected to replace a traditional synthetic adhesive depending on a petroleum base, accords with a sustainable development strategy, contributes to reducing consumption of fossil resources, avoids release of toxic substances such as formaldehyde and the like in the synthesis and use processes, and has a good application prospect. And the method is more environment-friendly. The bio-based polysaccharide raw material has good biocompatibility and degradability, and an ideal base material is provided for developing a green and safe biomedical adhesive.

Disclosed in the present invention are a gel having a regulatable free water content and morphology, a preparation method therefor, and the use thereof. The method comprises: S1, preparing a solution A from a natural polymer material; S2, mixing a small molecule material containing a positively charged polar group with the solution A to obtain a composite solution B; S3, mixing the composite solution B with a regulator to obtain a composite solution C, stirring same, then adding a condensing agent to the reaction system, and carrying out a curing crosslinking reaction; and S4, removing the regulator and the condensing agent to obtain the gel. By adjusting the concentrations of the natural polymer material and the regulator, gels having different morphologies can be prepared; the gel undergoes a physical process to remove hydrogen bond interaction between the gel and free water, so that the content of free water attached to the surface of the gel can be regulated, thereby regulating the physical and chemical properties of the gel. The gel of the present invention has regulatable morphology and controllable elastic modulus, and has many advantages such as good lubrication effect, good biocompatibility and biodegradability, capability of being biologically active, and capabilities of stimulating cell growth and accelerating wound repair.

The present embodiment relates to a biodegradable resin composition, a biodegradable film using the same, and a method for preparing the same, wherein the biodegradable resin composition comprises: a polylactic acid (PLA) resin; and a polyhydroxyalkanoate (PHA) resin. The PHA resin includes: a first PHA resin including a 3-hydroxyhexanoate (3HH) repeating unit; and a second PHA resin comprising a 4-hydroxybutyrate (4HB) repeating unit, thereby simultaneously improving the biodegradability, stretchability, and strength of the biodegradable film. Therefore, the biodegradable resin composition according to an embodiment of the present invention has excellent biodegradability and biocompatibility, and thus is environmentally friendly, and can ensure sufficient stretchability and strength thereof to produce a stretchable film, thereby being used for producing various products requiring moldability, and also being suitable for the production of various products requiring moldability. The present invention relates to a packaging material, such as a packaging material for disposable bags or food containers, and exhibits excellent properties.

The invention relates to the technical field of biological materials for 3D printing, in particular to a polyether-ether-ketone composite material with an enhanced 3D printing function and a preparation method of the polyether-ether-ketone composite material. The invention discloses a polyether-ether-ketone composite material with an enhanced 3D printing function. The material is prepared from the following raw materials in parts by mass: 75-85 parts of polyether-ether-ketone, 5-10 parts of a modified bioactive material, 1-3 parts of carbon nanotubes, 0.5-2 parts of an organic nucleating agent, 0.1-1 part of a biological regulator and 0.1-1 part of an antibacterial agent, the modified bioactive material is modified hydroxyapatite and / or modified tricalcium phosphate. According to the basic formula, the synergistic effect of multifunctional components is achieved, the defects of an existing PEEK material in the aspects of biological activity and crystallization performance are overcome through the components such as polyether-ether-ketone, the modified bioactive material and the carbon nanotubes which are meticulously proportioned, and excellent mechanical performance and biocompatibility are provided.

The invention relates to self-curing keratin 3D printing ink integrated with shear activation microcapsules and a preparation method of the self-curing keratin 3D printing ink, and belongs to the technical field of biological 3D printing and intelligent materials.The preparation method comprises the steps that high-molecular-weight soluble keratin powder is dissolved in a biocompatible water-based medium with the pH being 6.5-8.5, and after even mixing and defoaming are conducted, a keratin base solution is obtained; wrapping the core material in a corresponding shell to obtain a microcapsule with the average particle size of 1-10 microns; under the stirring condition, the microcapsules are evenly dispersed into a keratin base solution at the temperature of 0-8 DEG C until a uniform suspension system is formed, and the self-curing keratin 3D printing ink integrating the shear activation microcapsules is obtained. And the curing process of the ink is internalized in the printing behavior, so that the printing process is simplified, and the equipment cost and the operation difficulty are reduced. The cross-linking agent is effectively isolated, so that the ink can be stably stored for several weeks before printing without gelling, and the problem that double-component ink must be immediately used after being mixed is solved.

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

The invention discloses a preparation method of a pegylation acoustic catalysis effect black phosphorus loaded biological enzyme nano particle, which is a novel nano composite material based on material chemistry and pharmaceutical chemistry, and bacterial keratitis is treated by using the unique acoustic catalysis property of the nano particle. Nanoparticle synthesis mainly comprises the following steps: 1) pretreatment of commercial black phosphorus; (2) uploading biological enzyme iron-curcumin to black phosphorus in situ; and (3) synthesizing hyaluronic acid coupled phospholipid polyethylene glycol (DSPE-coated PEG2000-HA) and modifying the biological enzyme black phosphorus nanoparticles. The finally obtained nano composite material has good biocompatibility, ocular surface adhesion, biological enzyme activity and acoustic catalytic treatment effect on bacterial biofilm infection of eyes.

The invention provides a silicon-containing polyurethane material and a preparation method and application thereof.The silicon-containing polyurethane material comprises a hard segment and a soft segment, the hard segment is derived from reaction raw materials including diisocyanate and a chain extender, and the soft segment is derived from reaction raw materials including polysiloxane and macromolecular dihydric alcohol; in the process of preparing the silicon-containing polyurethane material by adopting the polysiloxane with the specific structure, rich fluorine atoms in the polysiloxane can be utilized to drive the polysiloxane to migrate to the surface of the material, so that a protective layer is formed on the surface of the material, and the biocompatibility and the biological stability of the material are enhanced. By adopting the mode, the silicon-containing polyurethane material with excellent biological stability, biocompatibility and mechanical property can be prepared on the premise of lower polysiloxane addition amount, and the problem that the biocompatibility and the mechanical property cannot be simultaneously considered when the polyurethane material is prepared by utilizing polysiloxane in the prior art is effectively solved.

This invention discloses a Zn-based framework material, Bi-Cur@Zn-MOF, its preparation method, and its applications in antibacterial and antioxidant properties, belonging to the field of functional materials and biomedical technology. The method specifically involves: dissolving zinc salt in water to obtain a zinc salt solution; dissolving curcumin and biotin together in water to obtain a mixed solution, and adjusting the pH of the mixed solution; mixing and stirring the zinc salt solution and the mixed solution evenly to obtain a precursor solution; subjecting the precursor solution to a hydrothermal reaction; after the reaction, performing solid-liquid separation and collecting the solid; washing and vacuum drying the solid to obtain the Zn-based framework material, Bi-Cur@Zn-MOF. The preparation method of this invention is green and simple, requiring no toxic reagents, and is suitable for large-scale preparation. The Bi-Cur@Zn-MOF prepared by this invention possesses both antibacterial and antioxidant functions, exhibits structural stability and good biocompatibility, and can be used to prepare medical dressings, food packaging materials, skin care products, wound repair, and antioxidant and antibacterial coatings, etc.

A method of preparing an injectable or oral storage stable formulation, comprising: contacting a biological species with a delivery system comprising biocompatible solid particles to form a complex; then optionally, lyophilising the complex to form a powder, and then dispersing the complex in a biodegradable gel material to form the formulation, comprising the complex embedded in the biodegradable gel material. Also related products, methods, and medical uses.

The application relates to the technical field of drug delivery, and discloses a polymer microcrystal patch fused with a biodegradable material and a preparation method thereof, which comprises a microneedle array and a supporting substrate made of raw materials, and is characterized in that the microneedle array is made of raw materials containing a cationic polymer, an anionic polymer, an ion shielding agent and an active ingredient. The preparation method comprises the following steps: filling a solution containing a cationic polymer and an active ingredient into a microneedle negative mold; and covering the surface of the solution with a layer of a solution containing an anionic polymer and an ion shielding agent. By introducing the ion shielding agent, the application effectively controls the ion crosslinking rate between the polymers, solves the problem of incomplete microneedle forming caused by too fast reaction, and significantly improves the forming quality of the microneedles. The method is carried out at room temperature, the conditions are mild, the bioactivity of the active ingredient can be effectively protected, and the used materials are good in biocompatibility and high in safety.

The invention belongs to the technical field of functional composite materials, and particularly relates to high-damping organic silicon-based composite hydrogel as well as a preparation method and application thereof. The method comprises the following steps: mixing polydimethylsiloxane, silicate ester and a polyvinyl alcohol aqueous solution in proportion, and emulsifying in an ultrasonic microreactor to form an oil-in-water emulsion with specific particle size distribution. Wherein after the oil phase in the emulsion is subjected to ultrasonic action, rapid chemical crosslinking is performed to form organic silicon microspheres, and finally the organic silicon-based composite water-based damping material with the damping factor larger than 0.5 is prepared. By regulating and controlling the particle size distribution of the organic silicon microspheres, the stacking density of the microspheres in the damping material is maximized, so that the friction between the microspheres and a gel network is enhanced, and high damping is realized. The elastic composite organic silicon material has good damping performance, molding processability, recoverability and biocompatibility, raw materials are environment-friendly and low in cost, and the elastic composite organic silicon material is suitable for large-scale production and can be widely applied to the fields of flexible wearing, elastic vibration isolation, flexible protection and the like.

The invention relates to the field of biomedical polymers, in particular to an antibacterial, compression-resistant and degradable pure sericin nano-composite gel dressing as well as a preparation method and application thereof. Main raw materials comprise sericin, magnesium lithium silicate, an initiator, a catalyst, an antibacterial agent and deionized water. The preparation method comprises the following steps: extraction of sericin, preparation of an inorganic nano-clay magnesium lithium silicate dispersion liquid, preparation of a gel pre-polymerization liquid, assembly of a sandwich model, injection of a sericin / magnesium lithium silicate gel pre-polymerization liquid, and preparation of the sericin / magnesium lithium silicate nano-composite gel. And carrying out post-treatment and packaging on the sericin / magnesium lithium silicate nano-composite gel dressing. The pure sericin protein hydrogel is prepared through interaction of hydrogen bonds and ionic bonds, the raw materials are non-toxic, and the pure sericin protein hydrogel has biocompatibility, high mechanical property, injectability, dissolvability and no pollution of dissolved products and can be used for wound dressing, drug delivery, biological binders, implantable electronic equipment and 3D biological printing.

The invention belongs to the technical field of biodegradability, and discloses a PHA coating film and a preparation method and application thereof.The PHA coating film is prepared from, by weight, 50-80 parts of PHA resin, 20-40 parts of PBAT resin, 5-15 parts of plasticizer, 3-10 parts of modified additive, 0.5-3 parts of coupling agent and 0.1-1 part of antioxidant, and the modified additive is prepared by mixing composite nanoparticles and composite microspheres according to the mass ratio of (3-5): 1. Through the combined effect of nano reinforcement, microsphere toughening and interface synergy, the processing stability and biocompatibility of the material are guaranteed while the mechanical property and water resistance of the PHA coating film are improved, the used raw materials are all bio-based or degradable materials, non-degradable components are not introduced in the modification process, the environment-friendly standard is met, and the preparation method is suitable for industrial production. White pollution is avoided, and the green trend of global packaging materials is met.

The invention discloses selective laser melting biological ceramic powder for dental restoration and a preparation method thereof, and belongs to the technical field of dental restoration materials. The composite ceramic material comprises the following raw materials in parts by weight: 50-100 parts of composite ceramic powder and 0.1-2 parts of an absorbent, the composite ceramic powder comprises at least two of Al2O3, ZrO2, SiO2 and TiO2; the absorbent comprises any one of TiC, SiC, ZrC, TiN and graphite; the fluidity of the selective laser melting biological ceramic powder for dental restoration is 39-40 s / 50 g. According to the invention, the SLM process adaptability of the material is obviously improved, the inherent biocompatibility, mechanical strength and stability of biological ceramics are considered, and the technical barrier that traditional biological ceramic powder is difficult to be directly used for selective laser melting is overcome; and a feasible material solution is provided for direct additive manufacturing of personalized dental prostheses with high performance and complex structures.

The invention relates to the field of polymer composite materials, and discloses a hollow glass nano-microsphere modified organic silicon elastomer and a preparation method thereof. The material is prepared from the following components in percentage by mass: 60-90% of vinyl silicone oil, 0.1-10% of hydrogen-containing silicone oil, 1-20% of an MQ silicon resin solution, 1-50 ppm of a catalyst, 0.05-0.3% of an inhibitor, 5-20% of a solvent and 0.1-5% of hollow glass nano-microsphere turbid liquid, the m / q value of MQ silicon resin is 0.5-1.0, and hollow glass nano-microspheres are silicon dioxide hollow submicrospheres. The preparation method comprises the following steps: mixing the raw materials, adding a catalyst, hydrogen-containing silicone oil and an inhibitor into two groups, mixing, defoaming, curing and forming. The material has good flexibility, ductility, air permeability and moisture permeability, high thermal stability and excellent biocompatibility, and is suitable for the fields of artificial skin and the like.

The invention belongs to the technical field of polymer materials, and particularly relates to a poly (p-dioxanone) modified composite material as well as a preparation method and application thereof. The invention provides a poly (p-dioxanone) / polyurethane composite material. The composite material is prepared by melting, blending and processing poly (p-dioxanone) and a polyurethane material. Experiments show that the poly (p-dioxanone) / polyurethane composite material prepared by the invention has excellent mechanical properties, and especially, epsilon t is obviously improved; in addition, the poly (p-dioxanone) / polyurethane composite material also has good thermal stability and improved processability. The invention provides a polymer material modification scheme with high cost effectiveness and good biocompatibility, and the polymer material is expected to be used for biomedical materials and has good application prospects.

The invention discloses a biological material with an efficient peculiar smell removal function, which is prepared from the following raw material components in parts by mass: 8 to 12 parts of manganese precursor, 0.8 to 1.2 parts of soluble metal salt, 4000 to 5000 parts of dispersing agent and 90 to 100 parts of conditioning agent. The composite nano material which takes small-particle-size thorn convex manganese dioxide as a core and loads metal ions is prepared by simple processes such as mixing, reaction, centrifugation and the like. The material can efficiently remove bad breath through a dual synergistic mechanism; small-particle-size manganese dioxide captures odor-producing bacteria through physical adsorption; meanwhile, released metal ions and hydrogen sulfide are subjected to chemical reaction to generate substances difficult to volatilize. Through the synergistic effect of physical interception and chemical conversion, the dual effects of blocking generation of peculiar smell from the source and immediately eliminating the peculiar smell are achieved. The product disclosed by the invention has biocompatibility and a long-acting peculiar smell removal function, can be widely applied to oral care products such as toothpaste and mouth wash, and provides an innovative solution for solving the problem of bad breath.

The present invention is a bio-electrode composition includes (A) an ionic resin, wherein the component (A) contains a resin having a structure selected from an ammonium salt, a lithium salt, a sodium salt, and a potassium salt of trissulfonium methide. This provides a bio-electrode composition capable of forming a living body contact layer for a bio-electrode, which is excellent in electric conductivity and biocompatibility and lightweight, can be produced at low cost, causes no significant decrease in the electric conductivity even when gets wet from water or when dried, and is soft with excellent stretchability and adhesiveness; a bio-electrode including a living body contact layer formed from the bio-electrode composition; and a method for producing the bio-electrode.

The application discloses a 3D-printed hydrogel support and a preparation method thereof, relates to the technical field of hydrogel materials, and aims to improve the antibacterial property and biocompatibility of the hydrogel material by modifying the raw material. The application first uses gelatin as the raw material, and processes the gelatin to increase the content of surface amino groups, so that the subsequent reaction is facilitated; then, the application also uses 2,5-thiophene dicarboxylic acid as the raw material, and controls the reaction conditions to react the 2,5-thiophene dicarboxylic acid with 2-aminobenzimidazole, so as to generate an antibacterial intermediate containing a free carboxyl group, a thiophene ring and an imidazole ring structure; the antibacterial intermediate is combined in the gelatin chain segment in the form of an amide bond, then under the action of a photoinitiator, the amide bond is broken to generate an acyl radical, and the acyl radical is further coupled and grafted with an acrylic ester double bond, so as to form a hydrogel cross-linking structure, and the hydrogel material is provided with sufficient compressive strength.

The invention belongs to the technical field of nano biological materials, and discloses a preparation method and application of a betulinic acid self-assembly nano composite system loaded with dihydromyricetin, and the nano composite system takes betulinic acid as a carrier and dihydromyricetin as an active component. The assembly mechanism of the prepared nano assembly system is as follows: the hydrogen bond interaction generated by combining the phenolic hydroxyl group of the dihydromyricetin molecule with the carbonyl group in the betulinic acid molecule and the carbonyl group in the carboxyl group in the betulinic acid molecule is the main non-covalent interaction force. The nano-composite system has good biocompatibility, and the HT-29 cells have a good uptake effect on the nano-composite system. The method has certain research and application prospects in the field of nano biological materials.

The invention discloses a honeycomb-shaped rigid-flexible two-phase particle and an application of the honeycomb-shaped rigid-flexible two-phase particle in photocuring 3d printing resin. The honeycomb rigid-flexible two-phase particle comprises a flexible polyurethane phase and a rigid silicon oxide phase. A preparation step S1 of preparing an emulsion containing polyurethane particles as a seed emulsion (emulsion A); s2, preparing an emulsion (emulsion B) containing a silicon oxide precursor and an initiator; s3, adding the emulsion B into the emulsion A, and uniformly mixing to obtain a mixed solution; and S4, under the dynamic action and the anaerobic condition, heating the mixed solution to 60-80 DEG C, and reacting for 20-24 hours to obtain the emulsion containing the honeycomb-shaped rigid-flexible two-phase particles. The emulsion containing the honeycomb-shaped rigid-flexible two-phase particles is added into the degradable polymer material with the photocuring property, so that the toughness and the strength of the polymer material can be improved at the same time, and the photocuring property and the biocompatibility of the polymer are not influenced; the material is suitable for being used as a filler to be added to various molded products prepared by high-precision photocuring 3d printing.

The application provides a method for constructing a double-signal sensing platform based on a non-copper nanometer enzyme AuPt@PBA@L-Pd and application, and a multifunctional nanometer composite material AuPt@L-Pd@PBA (hereinafter referred to as APL) with the effects of an oxidase-like enzyme, a peroxidase-like enzyme and a laccase-like enzyme is prepared. The composite nanometer enzyme has a regular cubic morphology, takes PBA as a base material, loads L-Pd through an amide bond, simultaneously collects the advantages of the MOF material PBA and L-Pd, has multiple enzyme-like effects, and can catalyze different chromogenic substrates. The AuNPs and PtNPs on the surface of APL not only provide good binding sites for antibodies, but also successfully prepare a biological composite probe Ab2@APL, further amplify the sensing signal, and improve the sensitivity of the sensing platform. It is worth mentioning that APL has the effect of a laccase-like enzyme, but does not contain copper ions, and further improves the biocompatibility. Based on the high catalytic activity and multifunctional nanometer enzyme Ab2@APL, a multi-signal sensing platform can be constructed, and the application prospect in more fields is wider.

The application discloses a water-soluble iridium complex and a phosphorescent film prepared from the same and application, relates to the technical field of functional materials, and the structural formula of the iridium complex is as follows: wherein n is an integer of 4-7. By introducing specific alkoxy with hydrogen bonding ability, the water-solubility of the iridium complex and the uniform dispersibility of the iridium complex in water are remarkably improved, and the compatibility of the iridium complex with CMC, SA, CS and other natural polymer materials is ensured. Meanwhile, the biodegradable natural polymer material is selected as a matrix, and the composite material system is endowed with good biocompatibility and environmental sustainability.

A bio-electrode composition contains (A) a reaction composite of a monomer having an ionic functional group and a carbon particle. The component (A) contains the carbon particle bonded to the monomer having a structure selected from the group consisting of salts of ammonium, lithium, sodium, potassium, and silver formed with any of fluorosulfonic acid, fluorosulfonimide, and N-carbonyl-fluorosulfonamide. Thus, the present invention provides: a bio-electrode composition capable of forming a living body contact layer for a bio-electrode which is excellent in electric conductivity and biocompatibility, light-weight, and manufacturable at low cost, and which prevents significant reduction in the electric conductivity even when wetted with water or dried; a bio-electrode including a living body contact layer formed of the bio-electrode composition; and a method for manufacturing the bio-electrode.

A system, method for preserving biological samples is disclosed. The illustrative method includes providing a biological sample for preparation and storage, and sealing the biological sample with a seal satisfying one or more criteria. The one or more criteria can be based on properties of the biological sample to ensure biological compatibility. The method includes processing the sealed biological sample for further sealing with another seal, the other seal being based on one or more other criteria.

The present invention relates to a process for volumetric printing of a shaped body comprising locally polymerizing a starting material comprising a bio-co-initiator.

The invention belongs to the technical field of composite materials, and particularly relates to an MXene-Prussian blue nano-antibacterial composite material as well as a preparation method and application thereof. According to the MXene-Prussian blue nano-antibacterial composite material provided by the invention, the Prussian blue nano-particles are synthesized on the surfaces of the MXene nanosheets in situ, the Prussian blue nano-particles are loaded on the MXene nanosheets in situ, and the Prussian blue nano-particles and the MXene nanosheets cooperate with each other to realize a low-temperature photothermal effect and ROS generation, so that the MXene-Prussian blue nano-antibacterial composite material shows remarkable antibacterial activity, and meanwhile, the damage caused by high photothermal performance of the MXene nanosheets is also reduced; the biocompatibility is good, and the antibacterial effect is improved; in addition, the synthesis raw materials and the synthesis process are improved, the MXene nanosheet of Ti is used, and the synthesis temperature is controlled, so that the antibacterial effect of the MXene-Prussian blue nano antibacterial composite material is further improved; therefore, the technical problem that the antibacterial effect of a novel antibacterial material with a single antibacterial mechanism in the prior art needs to be improved is solved.

The invention provides a sludge carbon-based bioelectrochemical constructed wetland for enhancing sewage denitrification. The sludge carbon-based bioelectrochemical constructed wetland comprises a wetland reactor and a circuit connecting device, the wetland reactor comprises a wetland pool as well as a water distribution layer, a lower filter material layer, an anode layer, an upper filter material layer and a cathode layer which are sequentially arranged in the wetland pool from bottom to top; the circuit connecting device comprises a power supply device and an adjustable resistor electrically connected with the power supply device; the adjustable resistor is respectively and electrically connected with the anode layer and the cathode layer through conductive wires; wherein the anode layer and the cathode layer are sludge biochar coated by a conductive metal net; the adjustable resistor is electrically connected with the conductive metal nets in the anode layer and the cathode layer through conductive wires respectively; the bioelectrochemistry-constructed wetland is coupled with the sludge biochar, and the biocompatibility and catalytic characteristics of the sludge biochar are utilized, so that the diversity and activity of microorganisms in an anode region are effectively improved, and the reduction effect of a cathode region on anions is promoted, thereby improving the removal effect on total nitrogen.

The application provides a bio-fluorescent intelligent membrane and a preparation method and application thereof, and the preparation method comprises the following steps: (1) adding isocyanate monomers and amino compounds into a first solvent and stirring to react; (2) adding a bio-fluorescent agent and a hydroxyl compound into the reaction system and stirring to react, so as to obtain a polyurea reactant; wherein the bio-fluorescent agent is obtained by addition polymerization reaction with the isocyanate monomers and the amino compounds as reaction raw materials; (3) printing into a film by using the polyurea reactant as a printing line by means of 4D printing, so as to obtain the bio-fluorescent intelligent membrane. In the application, the bio-fluorescent agent is self-prepared, and the bio-fluorescent agent and the hydroxyl compound are introduced into the polyurea material to perform polymerization reaction, so that the bio-fluorescent polyurea intelligent membrane has excellent bio-fluorescent performance; the bio-fluorescent intelligent membrane of the application has no toxic side effects on cells, has good biocompatibility, has good shape memory performance, and can realize intelligent regulation and control.