4132 results about "Antibacterial agent" patented technology

The invention provides antibacterial polypropylene plastic, and aims to obtain a composite antibacterial agent with the advantages of an inorganic antibacterial agent and an organic antibacterial agent by compounding the inorganic antibacterial agent and the organic antibacterial agent, and the antibacterial polypropylene plastic which is good in antibacterial property, good in migration resistance, good in mechanical property, good in mechanical property, good in mechanical property and the like is obtained by adding the obtained composite antibacterial agent into the polypropylene plastic. The invention discloses antibacterial polypropylene plastic with long-acting antibacterial property.

The invention belongs to the technical field of ceramic glaze, and particularly discloses antibacterial ceramic glaze and a preparation method thereof.The ceramic glaze is prepared from, by mass, 60-75 parts of basic glaze, 1-3 parts of nanometer titania, 2-6 parts of cosolvent, 0.5-3 parts of ochre, 5-10 parts of curcumin, 1-3 parts of stabilizer, 1-5 parts of rare earth antibacterial agent and 1-3 parts of sodium polyacrylate, and 1-6 parts of a composite additive. According to the antibacterial ceramic glaze and the preparation method thereof, the antibacterial performance, glossiness and smoothness of a glaze surface are improved, the crystal structure of the glaze can be refined through introduction of rare earth ions, the hardness of the glaze surface is enhanced, the wear resistance of a ceramic product is effectively improved, and the service life of the ceramic product is prolonged. Stable chemical bonds are formed in the glaze due to the special chemical properties of the rare earth elements, the resistance of the glaze to chemical substances such as acid and alkali is enhanced, and the chemical corrosion resistance of the ceramic glaze is improved.

The invention provides a broad-spectrum antibacterial peptide, an antibacterial agent and application, and belongs to the technical field of biological medicine. The invention provides a broad-spectrum antibacterial peptide. The broad-spectrum antibacterial peptide comprises an amino acid sequence as shown in SEQ ID No. 1. The minimum inhibitory concentration of the antibacterial peptide to gram-positive bacteria, gram-negative bacteria and fungi proves that the antibacterial peptide has obvious antibacterial activity to the gram-positive bacteria, the gram-negative bacteria and the fungi. The invention also verifies the minimum inhibitory concentration of the antibacterial peptide to clinical drug-resistant bacteria. The cytotoxicity of the SL-12 disclosed by the invention is relatively weak, the SL-12 only shows obvious cytotoxicity at 200 [mu] g / ml, and the minimum inhibitory concentration of the SL-12 is 6.25-12.5 [mu] g / ml; the SL-12 has no obvious hemolytic activity when the concentration is 100 [mu] g / ml or lower, and is high in safety.

The invention provides antibacterial ceramic and a preparation method thereof. The antibacterial ceramic comprises a blank body and a glaze layer, the blank body is prepared from the following raw materials: kaolin, diatomite, montmorillonite, soapstone, bamboo charcoal powder, a first antibacterial agent, a fluxing agent, a pore forming agent, an adhesive and a reinforcing agent; the glaze layer comprises the following raw materials: kaolin, diatomite, dolomite, tourmaline, sodium oxide, a second antibacterial agent, a binder, a stabilizer and a dispersant. The method comprises the following steps: firing a molded green body by adopting stepped segmented heating, and carrying out glaze firing by adopting stepped segmented heating after glazing, thereby obtaining the antibacterial ceramic. According to the antibacterial ceramic disclosed by the invention, the antibacterial agent is added into the green body and the glaze layer, so that the influence on the antibacterial property of the green body in the firing process of the green body is avoided, the antibacterial durability is further improved, the antibacterial effect is enhanced, and the antibacterial rate on pathogenic bacteria such as escherichia coli and staphylococcus aureus reaches 99.99%.

The invention relates to the technical field of multi-layer composite fabrics, and discloses a waterproof moisture-permeable composite fabric based on a bio-based material and a preparation method of the waterproof moisture-permeable composite fabric. The preparation method comprises the following steps: preparing an amino silanized zinc oxide / cellulose nanocrystal composite material, and carrying out mixed condensation polymerization on the amino silanized zinc oxide / cellulose nanocrystal composite material and vanillin cyclic carbonate to obtain an antibacterial agent; castor oil-based polyurethane, an antibacterial agent and a solvent are mixed and then subjected to electrostatic spinning, and after the electrostatic spinning and the pretreated polyester fabric are subjected to hot-pressing compounding, the obtained composite fabric has excellent waterproof and moisture permeable performance and good antibacterial performance.

A system, method, and article for delivering an antimicrobial agent into the lumen of a trans-dermal catheter are disclosed. In an embodiment, the system comprises an elongate member configured for insertion into a lumen of a catheter, and the elongate member containing an antimicrobial. An antimicrobial agent can be placed on an interior surface of a retaining ring.

The invention relates to the technical field of polypropylene plastics, in particular to a high-strength antibacterial polypropylene plastic and a preparation method thereof. The antibacterial polypropylene material comprises the following components in parts by weight: 60-80 parts of polypropylene resin, 5-15 parts of nano titanium dioxide and nano zinc oxide composite particles modified by a special organosilicon polymer, 3-8 parts of an antibacterial agent compounded by quaternary ammonium salt and bioactive peptide, 5-10 parts of a core-shell structure MBS toughening agent and 0.5-2 parts of a hindered phenol-thioether composite antioxidant. 1-3 parts of a calcium stearate processing aid; and 3-8 parts of dopamine modified chopped carbon fibers. The composite material is high in strength, tensile strength, bending strength and impact strength are remarkably improved, and larger external force can be borne; the antibacterial performance is excellent, and the antibacterial rate reaches 95%-99%; the preparation process is environment-friendly and efficient, and the product is good in stability and recoverable; product safety can be guaranteed, the service life is prolonged, and economic and social benefits are good.

The invention discloses an absorbable suture line for surgical suture and a preparation method thereof, and relates to the technical field of medical materials. The absorbable suture line for surgical suture is prepared from the following raw materials in parts by weight: 50 to 65 parts of polylactic acid, 15 to 20 parts of polyglycolic acid, 3 to 5 parts of sodium carboxymethyl cellulose, 3 to 8 parts of a toughening agent, 3 to 6 parts of an antibacterial agent, 0.3 to 0.8 part of a lubricating agent, 1 to 2 parts of sodium hyaluronate and 5 to 10 parts of polyvinyl alcohol. The toughening agent is obtained by reacting hydroxyethyl acrylate with ethylenediamine to generate a four-arm compound and then reacting with 6-caprolactone and DL-lactide. The absorbable suture line for surgical suture prepared by the invention has excellent tensile property and antibacterial property, and can meet the application requirements of clinical medical treatment.

The invention discloses bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement. The bone cement for orthopedic repair comprises solid-phase powder and a liquid-phase component, the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate, 10-15 parts of bioactive glass, 2-3 parts of a developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of a modified toughening agent and 2-3 parts of nano cellulose fibers; the liquid phase component is prepared from the following components in parts by weight: 40 to 50 parts of a sodium alginate solution, 10 to 20 parts of methacrylated gelatin, 0.5 to 1 part of transglutaminase, 30 to 60 parts of a citric acid buffer solution and 1 to 2 parts of an antibacterial agent. The preparation method comprises the following steps: reacting pentaerythritol with 12-oxododecanoic acid to obtain an intermediate 1, and reacting the intermediate 1 with dopamine to prepare the modified toughening agent. The bone cement for orthopedic repair prepared by the invention has good mechanical, self-repairing and antibacterial properties.

The invention relates to the technical field of film material preparation, and discloses a polylactic acid antibacterial packaging film and a preparation method thereof, the polylactic acid antibacterial packaging film comprises the following raw material components by weight: 60-80 parts of polylactic acid, 10-20 parts of polyvinyl alcohol, 10-20 parts of nano zinc oxide, 0.5-1.5 parts of nano cellulose, 1-3 parts of an antibacterial agent, and 10-15 parts of corn starch; the antibacterial agent is prepared from the following components in parts by weight: 5-10 parts of carboxymethylated chitosan and 0.5-2 parts of a dynamic disulfide bond cross-linking agent, the substitution degree of the carboxymethylated chitosan is greater than or equal to 80%, the antibacterial agent is prepared from tea tree essential oil and eugenol, and the dynamic disulfide bond cross-linking agent is bis (3-aminopropyl) disulfide. By adopting a composite system of carboxymethylated chitosan and a dynamic disulfide bond cross-linking agent, the technical effects of humidity-triggered self-repairing and mechanical property synergistic improvement are achieved, and compared with a packaging film with a single polymer base material in the prior art, the problem of antibacterial failure caused by mechanical damage is solved.

The invention relates to the technical field of TPU (thermoplastic polyurethane) protective films, in particular to a fluoride-free antibacterial TPU protective film and a preparation method thereof. The fluoride-free antibacterial TPU protective film comprises the following raw materials in parts by weight: 35-40 parts of TPU particles, 10-15 parts of a balance regulator, 8-12 parts of an antibacterial agent, 3-6 parts of an antioxidant, 3-5 parts of a heat stabilizer and 2-3 parts of a lubricant. According to the TPU protective film disclosed by the invention, TPU particles are matched with the antibacterial agent, the antioxidant, the heat stabilizer and the lubricant to serve as functional aids, and the balance regulator and the filling agent doped with flaky boron nitride are added to coordinate, cooperate and jointly achieve synergistic effects, so that the product is excellent in raw material interfacial compatibility, and the antibacterial property, barrier property and mechanical property of the product are improved in a coordinated and balanced manner; and the product has remarkable weather-resistant and acid-corrosion-resistant stability effects.

The invention relates to the technical field of antibacterial non-woven fabrics, and discloses an intrinsic antibacterial non-woven fabric and a preparation method thereof.The intrinsic antibacterial non-woven fabric is prepared by adopting a dip-coating method and by soaking a non-woven fabric in antibacterial slurry, taking out the non-woven fabric for drip drying and then drying the non-woven fabric to constant weight; wherein the antibacterial slurry is prepared by compounding antibacterial polyol with a synergistic antibacterial effect, nano titanium dioxide modified by a coupling functional phenolic hydroxyl Schiff base type antibacterial monomer and a branched antibacterial monomer. According to the intrinsic antibacterial non-woven fabric, the technical problems that in the prior art, an antibacterial agent is large in toxicity, prone to loss and insufficient in antibacterial spectrum coverage range are solved, and the intrinsic antibacterial non-woven fabric can also be applied to the field of filtering materials, the field of medical treatment and public health and the field of textile materials and has the beneficial technical effects of inhibiting bacterial growth and guaranteeing sanitation and safety.

The invention relates to the technical field of materials, and discloses an antibacterial composite pp material and a preparation process thereof.The antibacterial composite pp material is prepared from polypropylene as a main raw material and a compatilizer, a functional fiber modified additive, a rubber additive and the like as auxiliary materials through mixing and extrusion granulation processes. Wherein the functional fiber modified additive is medical stone fiber of which the surface is modified with a reactive macromolecular antibacterial agent, and the reactive macromolecular antibacterial agent can interact with a maleic anhydride group in a compatilizer structure in a subsequent melt extrusion process, so that the interface bonding performance between the medical stone fiber and polypropylene is greatly improved; further, the reinforcing effect of the medical stone fiber is fully exerted, so that the mechanical strength of the polypropylene material is effectively improved. In addition, triclosan in the structure of the macromolecular antibacterial agent has a broad-spectrum antibacterial effect, so that the polypropylene material can be endowed with excellent broad-spectrum antibacterial performance.

The invention discloses a metal-doped carbon quantum dot as well as preparation and application of the metal-doped carbon quantum dot in a nano antibacterial agent, citric acid, urea and tea polyphenol are taken as precursors, metal salt is added, carbon dot synthesis and metal ion doping are synchronously completed in one step through a hydrothermal method, and the metal-doped carbon quantum dot is prepared; the surfaces of the metal-doped carbon quantum dots are negatively charged, and the metal-doped carbon quantum dots have peroxidase-like activity and catalase-like activity at the same time; the metal ions adopt any one of Fe < 3 + >, Cu < 2 + > and Ce < 3 + >; the metal-doped carbon quantum dots are in a sphere-like shape. The metal-doped carbon quantum dots prepared by the preparation method disclosed by the invention have peroxidase-like activity and catalase-like activity at the same time through precise doping of metal ions, and the two activities have a synergistic effect in an oral periodontitis microenvironment, so that a good antibacterial effect is achieved.

The invention relates to the technical field of multi-layer composite fabrics, and discloses a moisture-absorption antibacterial layered composite fabric and a preparation method thereof. The preparation method comprises the following steps: carrying out melt spinning on polyamide and an antibacterial agent to prepare the antibacterial polyamide fiber; blending antibacterial polyamide fibers, cotton fibers and special-shaped section polyamide fibers, and knitting to obtain a lining fabric crude product; blending the antibacterial polyamide fiber and the modified cotton fiber, and knitting to obtain a surface fabric crude product; respectively padding the surface fabric crude product and the lining fabric crude product in the finishing liquid to obtain a surface fabric and a lining fabric, and compounding the surface fabric and the lining fabric to obtain the moisture-absorbing antibacterial layered composite fabric. The composite fabric has excellent antibacterial performance and good moisture absorption performance.

The preparation method of the antibacterial polyester fiber comprises the following steps: firstly, reacting a cationic antibacterial agent with a terminal carboxyl group with 4-sulfobenzoic acid monopotassium salt to obtain a high-temperature-resistant polymerizable cationic antibacterial agent; then taking purified terephthalic acid, a high-temperature-resistant polymerizable cationic antibacterial agent and ethylene glycol as raw materials, adding an auxiliary agent trimethyl phosphate and a catalyst to prepare uniform slurry, and adding the uniform slurry into an esterification reaction kettle; entering a polycondensation stage after esterification is finished, filling nitrogen after reaction is finished, pressurizing, discharging, and performing underwater granulation to obtain antibacterial polyester chips; then, the antibacterial polyester chips are dried until the water content is lower than 30 ppm, and the antibacterial polyester fibers are obtained through the melt extrusion spinning step; the fiber strength of the prepared antibacterial polyester fiber is larger than or equal to 2.8 cN / dtex, the antibacterial rate meets the AAA grade standard, and the antibacterial polyester fiber has good strength and is wide in application range.

The invention discloses a macromolecular antibacterial agent, an antibacterial nylon material as well as a preparation method and application thereof, and relates to the technical field of antibacterial macromolecular materials. According to the invention, lysine is used as a raw material, the polymer antibacterial agent is prepared through reactions such as dehydration ring formation and re-ring opening polymerization, the polymer antibacterial agent has the characteristics of high safety, biodegradability and good biocompatibility, and has the same polyamide main chain structure as nylon, the polymer antibacterial agent and nylon have good compatibility, and the polymer antibacterial agent and nylon 6 are fused and blended to form a nylon 6 sample. Through amide exchange reaction and hydrogen bond interaction between the macromolecular antibacterial agent and nylon 6 molecular chains, the antibacterial nylon material with excellent mechanical property and lasting and stable antibacterial effect is prepared, and the requirements of people for safety and environmental friendliness are met. The prepared antibacterial nylon material can be applied to antibacterial products such as textiles, daily necessities and packaging materials. Meanwhile, the macromolecular antibacterial agent and the antibacterial nylon material are simple in preparation process, low in raw material cost and suitable for industrial production.

The invention relates to the technical field of inorganic non-metallic materials, in particular to a quaternized cholic acid polyurethane modified polyvinyl chloride material, a preparation method and application. The quaternized cholic acid polyurethane polymer is based on a polyurethane elastomer developed by using cholic acid molecules with a rigid skeleton as a hard segment unit and flexible oligomeric ethylene glycol as a soft segment unit, hydroxyl on cholic acid polyurethane is quaternized to prepare cation modified cholic acid polyurethane, and the cation modified cholic acid polyurethane simulates amphiphilic characteristics of natural peptides. The quaternized cholic acid polyurethane is introduced into a polyvinyl chloride (PVC) matrix as an antibacterial agent, so that the growth of microorganisms such as bacteria and molds can be effectively inhibited, the antibacterial property is achieved, bacteria breeding on the inner surface of a pipeline is avoided, and the composite material is endowed with better biocompatibility and antibacterial property; meanwhile, the quaternized cholic acid polyurethane can effectively improve the strength and toughness of the PVC material; wide application prospects are realized.

The invention relates to the field of film materials, and discloses a degradable antibacterial film material and a preparation method thereof.The film material comprises degradable matrix resin, a modified additive, a plasticizer and a lubricant; the modified additive is prepared by loading a natural antibacterial agent on a modified flame-retardant composite filler; the modified flame-retardant composite filler is prepared by reacting cinnamyl aldehyde with a flame-retardant composite filler and forming a complex with zinc acetate dihydrate; the flame-retardant composite filler is prepared by reacting epoxidized composite filler with 1, 5-naphthalene diamine and then further reacting with phytic acid; according to the invention, the natural antibacterial agent is loaded in the modified flame-retardant composite filler through a vacuum impregnation method, and the mechanical property, antibacterial property and flame-retardant property of the material are enhanced by adding the modifying additive, so that the flame-retardant and antibacterial composite material has the advantages that the flame-retardant and antibacterial properties of the material are improved, and the service life of the material is prolonged. Meanwhile, diffusion / permeation of gas and water molecules in the film is adjusted.

The invention discloses a preparation method of an antibacterial PEEK material for bone implantation. The preparation method comprises the following steps: carrying out sand blasting treatment on the surface of a PEEK sample; immersing the sandblasted PEEK sample into a mixed solution containing concentrated sulfuric acid and hydrogen peroxide, and carrying out chemical sulfonation treatment; immersing the sulfonated PEEK sample into a dopamine solution, so that dopamine is oxidized and self-polymerized on the surface to form a PDA coating; immersing the PEEK sample with the PDA coating into an antibacterial drug solution, so that the antibacterial drug is loaded on the surface; carrying out heat treatment on the PEEK sample loaded with the antibacterial drug; thoroughly cleaning the sample, removing uncombined antibacterial drug molecules, and drying; through sand blasting treatment and sulfonation treatment, the surface roughness and hydrophilicity of the PEEK material are remarkably improved, and favorable conditions are provided for adhesion of a dopamine coating and an antibacterial agent; due to introduction of the dopamine coating, the biocompatibility and the adhesion of the material are enhanced, and the dopamine coating also serves as an effective carrier of antibacterial drugs, so that the antibacterial function is maximized.

The invention relates to the technical field of biological sample preservation, in particular to a sample preservation reagent for a giant spiny frog InDel molecular marker and a preparation method of the sample preservation reagent, degradation of DNA in the preservation process can be remarkably reduced through multiple action mechanisms of maintaining the pH value stable through a buffer solution system, inhibiting nuclease activity through a nucleic acid protective agent, scavenging free radicals through an antioxidant and the like, and the preservation effect is good. The method has the advantages that the cell stabilizer is added, DNA completeness is guaranteed, a reliable template is provided for follow-up accurate detection of InDel molecular markers, protective films can be formed around cells by the aid of the cell stabilizer, the cells are prevented from being damaged by ice crystals, osmotic pressure balance of the cells is maintained, high activity of the cells can be kept in the storage process, and follow-up extraction of high-quality DNA from the cells is benefited; the addition of the antibacterial agent can effectively inhibit possible microbial contamination of the sample in the preservation process, prolong the preservation time of the sample, and ensure the quality and safety of the sample.

The invention discloses a highly antibacterial PVC plate and a preparation method thereof, and belongs to the technical field of PVC plates. Comprising the following raw materials in parts by weight: 70-80 parts of SG5 type PVC resin, 16-22 parts of calcium carbonate, 15-25 parts of chlorinated polyethylene, 18-28 parts of acrylic resin, 7-21 parts of a multi-effect antibacterial agent and 4-6 parts of a lubricant. Wherein calcium carbonate can improve the processing performance of PVC and enhance the mechanical property of the board; the chlorinated polyethylene can enhance the aging resistance and flexibility of the plate; wherein the acrylic resin can enhance the processability, aging resistance and flexibility of the PVC; the multi-effect antibacterial agent can enhance the antibacterial property, heat resistance and flexibility of the plate, belongs to macromolecules and is stable in performance; therefore, the prepared PVC plate has excellent processability, aging resistance and mechanical property, has stable and efficient antibacterial property, heat resistance and flexibility, and has important application value in the technical field of PVC plates.

The invention provides a special rare earth antibacterial master batch for a PVC antibacterial air conditioner condensate pipe and a preparation method of the special rare earth antibacterial master batch. The problems that an existing PVC condensate pipe is poor in antibacterial performance, and a rare earth antibacterial agent and PVC resin are poor in compatibility and dispersity are solved. The master batch comprises PVC carrier resin, a rare earth antibacterial agent, a dispersing agent, a plasticizer, a heat stabilizer, a lubricant and a bulking agent, and the rare earth antibacterial agent is prepared by mixing rare earth oxide and inorganic oxide according to a specific proportion and carrying out mechanical dispersion, high-energy dispersion, secondary mechanical dispersion, drying, tunnel kiln firing and grinding treatment. The preparation method of the special rare-earth antibacterial master batch for the PVC antibacterial air conditioner condensate pipe comprises the steps of raw material pretreatment, raw material premixing, coupling treatment, mixing and plasticizing, melt extrusion, granulation molding and the like, and through a refining process and a supercritical carbon dioxide technology, it is ensured that a rare-earth antibacterial agent is uniformly dispersed and stably combined in a PVC matrix; the master batch with excellent antibacterial property, thermal stability and mechanical property is prepared.

The invention provides a novel organic conjugated molecule, the long conjugated D-pi-A structure enables the organic conjugated molecule to form nanoparticles with high positive charge density more easily, and meanwhile, a large amount of active oxygen generated under the irradiation of white light can efficiently split bacterial cell membranes and slow down the generation of bacterial drug resistance. The organic conjugated molecule as shown in the formula (I) has a strong photodynamic killing effect on gram-negative bacteria and gram-positive bacteria, and is low in hemolysis rate and good in biocompatibility. The invention provides guidance for developing a high-efficiency and low-toxicity photodynamic antibacterial agent.

The invention discloses a nano-antibacterial agent for treating biofilm infection through Prussian blue and a preparation method and application thereof.According to the nano-antibacterial agent, hollow Prussian blue (HPB) serves as a carrier to load a substance with anti-inflammatory and anti-oxidation effects, a metal polyphenol network structure is formed through chelating of tannic acid (TA) modified by hyaluronic acid (HA) and high-valence metal ions, and the nano-antibacterial agent is used for treating biofilm infection through Prussian blue. And the MPNs are packaged to obtain the product. All the components of the nano antibacterial agent have a synergistic effect, MPNs formed by chelating TA modified by hyaluronic acid and high-valence metal ions in the antibacterial agent have good photo-thermal performance, and light energy can be converted into heat energy for photo-thermal therapy. According to the invention, the nanoparticles for photo-thermal antisepsis and anti-inflammation are constructed, so that comprehensive treatment of anti-biofilm and anti-inflammatory effect is realized, and healing of infected parts is promoted. And the antibacterial agent has good biocompatibility and high biological safety, and is very suitable for replacing antibiotics to treat biological membrane infection.

The invention relates to the field of plastic films, and particularly discloses a bio-based antibacterial cool-feeling breathable film and a preparation method thereof. The bio-based antibacterial cool-feeling breathable film is prepared from the following raw materials in percentage by weight: 49 to 66.5 percent of matrix resin, 30 to 40 percent of pore-foaming agent, 1 to 3 percent of silane modified cellulose nanofiber, 1 to 2 percent of antibacterial agent, 1 to 5 percent of composite cool-feeling agent and 0.5 to 1 percent of auxiliary agent, the matrix resin comprises PBAT resin and PLA resin in a mass ratio of (7: 3)-(5: 5); the composite cool feeling agent comprises nano aluminum nitride and graphene in a mass ratio of (5-15): 1. The bio-based antibacterial cool-feeling breathable film can be used for medical dressings, disposable medical supplies, mother and baby products and the like, and has the advantages of being good in breathability and moisture penetrability, high in antibacterial capacity, lasting in antibacterial effect, high in mechanical strength, high in cool-feeling coefficient, comfortable to wear and not prone to stuffiness.

The invention discloses a preparation method of a dual-pH intelligent response drug-loaded ureteral stent, which belongs to the technical field of medical instruments, and is characterized in that the dual-pH intelligent response drug-loaded ureteral stent comprises a dual-pH intelligent response drug-loaded coating and a bare stent; wherein the dual pH intelligent response drug-loading coating contains polymer-modified porous silicon dioxide drug-loading particles, and the main effect of the drug-loading coating is that after the pH of the internal environment of the ureteral stent is changed due to bacterial infection, the antibacterial agent is controllably released through the structural change of the drug-loading particles or the property of the surface polymer is changed, so that the bactericidal ability is improved; and a complex infection environment can be accurately dealt with.

The invention belongs to the technical field of polyurethane, and particularly relates to a low-swelling-rate hydrophilic polyurethane sponge composite material as well as a preparation method and application thereof. The low-swelling-rate hydrophilic polyurethane sponge composite material is prepared from a component A and a component B according to the mass ratio of 100: (50-55), and the component A comprises the following raw materials: a foaming agent, wollastonite powder, an antibacterial agent, emulsifying wax and a polyether type cross-linking agent; the component B comprises polyether ester polyol and toluene diisocynate; the polyether type cross-linking agent is prepared by taking triethanolamine as an initiator and carrying out ring-opening polymerization reaction with EO; the polyether ester polyol is prepared by taking polyethylene glycol, diethylene glycol, trimethylolpropane and adipic acid as raw materials through esterification reaction. The hydrophilic polyurethane sponge prepared from the composite material is good in hydrophilicity, high in aperture ratio, fine and smooth in foam hole, low in swelling ratio and excellent in mechanical property.

The invention discloses a double-layer gel patch for diabetic wounds and a preparation method of the double-layer gel patch. The double-layer gel patch is composed of an upper gel layer and a lower gel layer, and when the double-layer gel patch is used, the lower gel layer is attached to the surface of skin; the upper gel layer is prepared from methacrylated gelatin, oxidized hyaluronic acid, a photoinitiator and an anti-inflammatory drug, and the lower gel layer is prepared from 3-carboxyphenylboronic acid grafted gelatin, dihydrocaffeic acid grafted epsilon-polylysine and an antibacterial agent. The double-layer gel disclosed by the invention has high mechanical strength and absorbability, and meanwhile, a sequential treatment strategy of firstly resisting bacteria and then resisting inflammation can be realized.

The invention discloses a rare earth antibacterial ceramic and a preparation method thereof, and belongs to the technical field of ceramic materials, the rare earth antibacterial ceramic comprises a base material, a rare earth antibacterial agent and an auxiliary additive, the base material is coated with a zirconium silicate coating layer; the matrix material is one of aluminum oxide or zirconium oxide, the rare earth antibacterial agent is a ternary composite oxide composed of at least three lanthanide elements, the lanthanide elements comprise Ce, Y, La and Nd, and the invention provides a preparation method of the composite material. Through collaborative innovation of ternary rare earth composite modification, zirconium silicate interface coating and a gradient sintering process, the core problems of single antibacterial spectrum, high-temperature failure and insufficient durability of traditional antibacterial ceramic are solved, and the antibacterial property, stability, biological safety and mechanical property are remarkably improved; and the method has clear technical progress and industrial application value.