93 results about "AMINO BASE" patented technology

Immunogenic targets associated with one or more types of cancer, wherein the immunogenic target includes a shared splicing amino acid-based neoantigen present in any of SEQ ID NOs: 1-2545, or a nucleotide coding therefor, are described, as well as uses thereof, and methods of identifying such immunogenic targets. Particular embodiments relate to immunotherapies for treating a type of cancer, and methods of treating a type of cancer by administering such immunotherapies, wherein the immunotherapy includes an immunogenic target including a shared splicing amino acid-based neoantigen present in any of SEQ ID NOs: 1-2545, or a nucleotide coding therefor.

The invention discloses an aminopropyltriethoxysilane modified gasified slag mesoporous material and application thereof to carbon dioxide adsorption, gasified slag is used as a raw material, the gasified slag is ground by a ball mill and then soaked in hydrochloric acid to prepare the mesoporous material, then aminopropyltriethoxysilane is used for modification, and the mesoporous material is obtained. The amino group is introduced into the surface of the mesoporous material in a chemical bond mode to realize firm combination with a mesoporous material framework, and the aminopropyltriethoxysilane modified gasification slag mesoporous material is obtained. Compared with the prior art, the obtained mesoporous material has good chemical stability and can be used in high temperature, strong acid and strong alkali for a long time; and the amino group on the mesoporous material has strong alkalinity, can be subjected to acid-base reaction with carbon dioxide, realizes capture of carbon dioxide, and has good adsorption rate and adsorption capacity. Meanwhile, the preparation method of the mesoporous material is easy to operate, raw materials are cheap, high-quality utilization of solid waste is achieved, and economic benefits are improved.

The present invention relates to a solid laundry composition. More particularly it relates to a solid laundry composition which provides improved fragrance perception. It is desired to provide solid laundry composition which provides improved fragrance intensity on wet fabrics, also preferably on both wet fabrics and post drying the fabrics. The present inventors have found that when a solid laundry composition has a surfactant system comprising alkyl aryl sulphonate surfactant and an amino acid-based surfactant in combination with specific chelating agents it provides for surprisingly higher fragrance intensity, preferably on wet fabrics, more preferably both on the wet fabrics and after drying the fabrics. It was also found that the composition according to the first aspect of the present invention provides for reducing / removing the malodour producing soil from the fabrics.

The invention belongs to the technical field of polyurethane, and particularly relates to bio-based flame-retardant polyurethane polystyrene foam. The bio-based flame-retardant polyurethane polystyrene foam is prepared from the following raw materials in parts by weight: 60 to 75 parts of amino acid-based modified polyether polyol; 25-40 parts of a nitrogen and phosphorus-containing hydroxyl-terminated modified polymer; 380 to 440 parts of modified isocyanate; 100 to 130 parts of chlorinated paraffin; 40 to 60 parts of filler; 8-10 parts of silicone oil; 80 to 100 parts of a propellant; and 3-5 parts of a catalyst. Bio-based raw materials such as castor oil and amino acid are introduced into the molecular structure of the polyurethane polystyrene foam through chemical modification, so that the biodegradability of the material is improved; a proper polymeric monomer is screened, and a flame-retardant element chlorine is introduced into a polyether molecular structure through chemical polymerization and forms multi-element synergy with nitrogen and phosphorus elements bridged through ester bonds, so that the content of the flame-retardant element in the polystyrene foam material is effectively increased, and the flame retardance is improved.

The invention discloses a synthesis method of an amino-acid-based MOFs (Metal-Organic Frameworks) derived nano-enzyme, and relates to the technical field of nano-enzyme synthesis, the synthesis method of the amino-acid-based MOFs derived nano-enzyme comprises the following steps: step 1, selecting proper metal ions and organic ligands; step 2, ultrasonic dispersion; step 3, precipitate drying; and step 4, activating treatment of the nano enzyme. The MOFs-derived nano-enzyme with alkaline phosphatase activity is synthesized by taking natural amino acid as a ligand and one of ions of zirconium, copper and iron as a metal node and introducing defects by a method of adding an acidic regulator in synthesis, and the crystal structure of the nano-enzyme is not changed under the introduction of the defects, so that the alkaline phosphatase activity of the MOFs-derived nano-enzyme is improved. The MOFs-derived nano-enzyme has the advantages that the MOFs-derived nano-enzyme is modified, the catalytic hydrolysis activity of the MOFs-derived nano-enzyme on phosphate substrates is greatly improved, good substrate specificity is shown, the structure of the MOFs-derived nano-enzyme does not change after long-term incubation under acidic, alkaline and high-temperature conditions, and compared with natural enzyme, the MOFs-derived nano-enzyme has good stability, pH stability and reusability.

To provide a composition for hair capable of improving the volume of hair while suppressing the entanglement of hair, and to provide a hair treatment method using the composition for hair.SOLUTION: This composition for the hair is obtained by formulating (A) an amino acid-based cationic surface active agent with (B) one or more kinds selected from pantothenic acids, vitamin C or its salts, vitamin B3 or its salts and vitamin B6 or its salts. The hair treatment method uses the composition for hair.SELECTED DRAWING: None

The invention provides a water-based composite electrolyte and a preparation method and application thereof. The water-based composite electrolyte comprises soluble zinc salt, amino acid hydrochloride additives and deionized water. The aqueous composite electrolyte can be used for a symmetrical button cell, a half cell or an aqueous zinc ion total cell. By adjusting zinc ion deposition on the surface of the zinc electrode, the growth of zinc dendrites is reduced, and the shuttle effect of the iodine positive electrode is inhibited, so that the coulombic efficiency and the cycle performance of the water-based zinc-iodine battery are improved. The additive disclosed by the invention can be adsorbed on the surface of a zinc negative electrode, delays the nucleation process and inhibits the growth of zinc dendrites; the form of hydrochloride can play a role of a buffer solution, stabilize the pH value of the electrolyte, inhibit the corrosion of the zinc negative electrode and reduce the hydrogen evolution reaction; the hydrochloride form can weaken the protonation effect of amino acid groups and enhance the electrostatic interaction between the amino acid groups and the polyiodide, so that the shuttle effect is inhibited, and the coulombic efficiency and the cycle performance of the aqueous zinc-iodine battery are improved.

To provide a method for reducing cracks in transparent solid compositions containing amino acid-based gelling agents.SOLUTION: The present invention provides a method for reducing cracks, including blending a dimer diol and / or a glycerin fatty acid ester with a transparent solid cosmetic preparation containing an amino acid-based gelling agent; a transparent solid cosmetic preparation containing an amino acid-based gelling agent and a dimer diol and / or a glycerin fatty acid ester; and a premix for preparing such a cosmetic preparation.SELECTED DRAWING: Figure 4

An extracellular vesicle-modified metal implant with immunoregulatory and osteoinductive dual functions achieved through use of mussel-derived adhesion peptides and azidylated extracellular vesicles o

A chimeric or fusion protein for inducing an immune response against P. gingivalis, the protein comprising a first polypeptide linked to a second polypeptide, wherein A) the first polypeptide comprises or consists of the amino acid sequence of an active site of Arg- or Lys-gingipain of P. gingivalis, or a sequence that is at least 80% identical thereto, and B) the second polypeptide comprises or consists of the amino acid sequence of an adhesin domain of Arg- or Lys-gingipain of P. gingivalis, the second polypeptide a) preferably does not comprise part or all of the sequence of a truncated adhesin domain (CAD), and / or b) comprises an amino acid sequence that corresponds substantially to the full length of the DUF2436 domain of Arg- or Lys-gingipain, or a sequence that is at least 80% identical thereto.

The invention discloses application of an amino acid-based assembly, a reagent of the amino acid-based assembly, a cosmetic composition and a preparation method and application of the cosmetic composition, and relates to the field of cosmetics. The invention provides application of an amino acid-based assembly in preparation of a reagent for improving stability of blue copper peptide. The amino acid-based assembly comprises arginine malate and / or arginine glycyrrhizinate. The amino acid-based assemblies such as arginine malate and glycyrrhizic acid arginine salt can buffer the blue copper peptide in the system and weaken copper ion competition, the stability of the blue copper peptide can be effectively improved, and the problem that the blue copper peptide is difficult to apply in the technical field of cosmetics is solved.

The present application relates to the technical field of compound synthesis, and in particular to a preparation method of amino acid-based lactam, comprising: A) reacting an alpha-amino acid and an alpha-hydroxy acid ester in a first solvent under the action of a first catalyst to obtain N-(hydroxyacyl)-amino acid ester; B) reacting the N-(hydroxyacyl)-amino acid ester in a second solvent under the action of a second catalyst to obtain amino acid-based lactam with a structure shown in Formula I; in Formula I, R1 and R2 are independently selected from one of hydrogen, a C1-C4 straight-chain or branched-chain aliphatic hydrocarbon group, a substituted or unsubstituted C6-C30 aryl group, a protected amino group, a protected carboxyl group, a protected hydroxyl group and a protected sulfydryl group; and the protecting group is one of an alkoxycarbonyl group, an acyl group and an alkyl group. The present application can solve the problems in the existing lactam synthesis process, such as high raw material risk, complicated process, and difficult product purification.

The invention relates to the technical field of degradable materials, in particular to a preparation method of an amino acid-based degradable material, which comprises the following steps: S1.1, converting calcium glutamate into an amidate under the catalytic action; s1.2, mixing the amidate with threonine phosphate to prepare a sediment; s1.3, the sediment is further modified with citric acid, and a degradable base material is obtained; and S1.4, fully and uniformly mixing the degradable base material, the bioactive molecules, the plasticizer, the stabilizer and the antioxidant, and performing extrusion molding by using a double-screw extruder to obtain the amino acid-based degradable material. Wherein the degradable base material is prepared from calcium glutamate, threonine phosphate and citric acid according to the mass ratio of 7: (3-4): (0.5-1); the calcium glutamate is adopted to construct a material basic framework, the phosphothreonine further enhances the structural stability and improves the mechanical strength, the mechanical performance and the degradation period are balanced, and wide application prospects are achieved.

The invention provides a recombinant human-derived III-type collagen and a construction method of the recombinant human-derived III-type collagen. The recombinant human source III type collagen comprises 468 amino acids, and a basic repeating unit of the recombinant human source III type collagen is GERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGER. The recombinant human source III type collagen comprises 468 amino acids, the recombinant human collagen provided by the invention is 100% identical to a corresponding part of a natural collagen gene sequence, has a triple helix structure, and has good hydrophilicity and stability. The production method comprises the following steps: construction of escherichia coli genetically engineered bacteria, and fermentation culture of the genetically engineered bacteria; and purifying the recombinant human collagen. The method does not cause immunological rejection when used in a human body, and can be widely applied to the fields of biomedical materials, cosmetics and the like.

The invention discloses the creation and application of an aromatic amide biosensor, and belongs to the field of bioengineering technology. The biosensor in the present invention is based on the amino acid motif of the transcriptional regulator AmiC-AmiR derived from Pseudomonas aeruginosa, and the RBS of AmiC and AmiR are optimized respectively, and the tyrosine at position 83 of AmiC is mutated to isoleucine, and the threonine at position 233 is mutated to cysteine. Compared with the wild-type transcriptional regulator AmiC-AmiR, the biosensor provided by the present invention has a good linear relationship in its responsiveness to aromatic amides, and the response range is between 0 and 10 mM after the optimization of RBS. The biosensor that can respond to aromatic amides provided by the present invention can be used for the detection of aromatic amides, screening strains that metabolize aromatic amides, or laying the foundation for subsequent research on aromatic amide production metabolic pathways, and has a wide range of application scenarios.

The invention relates to the field of insecticide reagents, and provides a thiamethoxam-containing composite suspension insecticide and a preparation method thereof. The pesticide is formed by compounding thiamethoxam-loaded amino acid-based nanoparticles and bimetallic nanoparticles, and polyvinylpyrrolidone, fatty alcohol-polyoxyethylene ether, xanthan gum, glycerol, sodium benzoate, magnesium aluminum silicate and a citric acid-sodium citrate buffer solution are supplemented, so that the slow release property and stability of the pesticide are improved. The thiamethoxam-loaded amino acid-based nanoparticles are prepared through ultrasonic dispersion, nano-micelle synthesis and freeze drying, and the thiamethoxam-loaded bimetallic nanoparticles are obtained through metal polyphenol coordination self-assembly and vacuum drying. The preparation adopts high-shear dispersion and low-speed stirring and curing processes, so that uniform dispersion of nanoparticles is ensured, and the suspension stability is improved. The insecticide prepared by the invention has a better slow-release control effect, the bioavailability of thiamethoxam is improved, the environmental pollution is reduced, and the insecticide is widely applied to prevention and control of agricultural pests.

The invention discloses a hydrogen-bond-rich bionic artificial alpha-amino-acid-based anthraquinone derivative and a preparation method and application thereof in an aqueous flow battery, and relates to the technical field of electrochemical energy storage. 1, 5-DHAQ and a methanol solution are added into a flask, KOH is added, NaS2O4 is added into the mixture in an ice-water bath, a formaldehyde solution is added after color change, an H2O2 aqueous solution is added after 12 h, hydrochloric acid is used for acidification, and the hydrogen-bond-rich bionic artificial alpha-amino-acid-based anthraquinone derivative is obtained. Washing and drying the precipitate; the preparation method comprises the following steps: adding 2, 4, 6-trichlorotriazine into DMF (Dimethyl Formamide), stirring to generate a white solid, adding dichloromethane and sodium bromide, stirring, adding 1, 5-dihydroxy-2, 6-bis (hydroxymethyl) anthracene-9, 10-diketone, washing with a Na2CO3 solution, washing with HCl, drying, adding 2, 6-bis (bromomethyl)-1, 5-dihydroxyanthracene-9, 10-diketone and cysteine into KOH, stirring at 60 DEG C overnight, and pickling to obtain Cys-DHAQ.

The present invention relates to a mutated filamentous fungal host cell producing a secreted polypeptide of interest, wherein the native putative steroid dehydrogenase is modified, truncated, partially or completely inactivated, present at a reduced level compared to the non-mutated parent cell or eliminated, and wherein the native putative steroid dehydrogenase comprises at least one conserved amino acid motif selected from the group consisting of: YGAR and / or VPHS[W / Y]F and / or QC[A / V / S]RRL and / or LKKYTLP and / or CPHYT, and a method of producing a secreted polypeptide of interest in said cell, as well as a method of producing said cell.

The invention relates to a cell attachment peptide containing an RGD amino acid motif, characterized by a material-side motif derived from poly-L-lysine and a cell-side motif derived from vitronectin. The peptide may be used to functionalize materials for use in cell cultures, such as microcarriers, scaffolds, and substrates.

Substituted 5-membered ring molecules substituted with fluorinated benzyl and amino acid groups having formula (I), and derivatives thereof, are disclosed herein. The substituted 5-membered ring molecules have herbicidal activity and can be used to control undesirable vegetation. Compositions, methods of making, and methods of controlling undesirable vegetation using substituted 5-membered ring molecules are also disclosed.

The invention relates to an amino acid surfactant useful in personal care products, especially cleansing products, which has excellent capability of surface modification to provide hydrophobi-city, preferably having better foaming and thickening properties than other amino acid based sur-factants.

The invention discloses a design method of rare earth-amino acid based multifunctional hydrogel. The hydrogel takes polyacrylamide-co-poly (2-acrylamide-2-methylpropanesulfonic acid) as a matrix and comprises the following components: polyvinyl alcohol, acrylamide, 2-acrylamide-2-methylpropanesulfonic acid, threonine, europium nitrate hexahydrate and terbium nitrate hexahydrate, and the formed amino acid-based hydrogel is doped with rare earth ions (such as europium ions and terbium ions). The hydrogel has fluorescent and conductive dual sensing channels, and rare earth-amino acid is used for physical crosslinking, so that a stronger cross-linked network is provided, and the mechanical property is enhanced; meanwhile, the hydrogel can freely adjust the mechanical property and the fluorescence intensity by changing the amino acid content, responds to the external ion environment, and has high sensing sensitivity (GF = 7.07) and tensile property (strain = 780%). The hydrogel sensor is stable in performance and convenient to prepare, the application range of the rare earth hydrogel is widened, and the hydrogel sensor has a good development prospect.

The present application provides compositions and methods for increasing safety, selectivity, and efficacy of transduction of human cells, including human long-term repopulating and hematopoietic stem cells (LT-HSC) and human cancer cells, by adenovirus vectors through multiplexed targeting of virus attachment and internalization receptors. Multiplexing targeting Ad vector receptor specificities through the combination of i) restricting fiber-specific attachment receptors, ii) deleting the RGD amino acid motif from the penton base protein, and iii) inserting into Ad penton base protein of peptides that lack the RGD amino acid motif and enable vector interaction with integrin classes expressed on target cells, allows for the improvement of safety, selectivity, and efficacy of vector-mediated transduction of human cells in vitro and after intravenous vector administration in vivo.

The present invention relates to a method for attaching a 5′-nicotinamidnucleobasedinucleotide (NND)-capped nucleic acid sequence to a fusion protein or to a complex, comprising (a) contacting (i) a heterologous fusion protein which comprises a poly(peptide) of interest being fused to a tag, or (ii) a complex wherein a protein is under physiological conditions complexed with a tag with the 5′-NAD-capped nucleic acid sequence and an ADP-ribosyltransferase (ART) under conditions wherein the 5′-NND-capped nucleic acid sequence is covalently attached to the tag, wherein the tag comprises a recognition motif of the ART and preferably comprises or consists of (i) SEQ ID NO: 1 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif DVRPVRD (SEQ ID NO: 7) is conserved and preferably SEQ ID NO: 7 is conserved; (ii) SEQ ID NO: 2 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif DVRPVRD (SEQ ID NO: 7) is conserved and preferably SEQ ID NO: 7 is conserved; (iii) SEQ ID NO: 3 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif DVRPVRD (SEQ ID NO: 7) is conserved and preferably SEQ ID NO: 7 is conserved; (iv) SEQ ID NO: 4 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif LADGVEGYLRASEASRDRVE (SEQ ID NO: 8) is conserved and preferably SEQ ID NO: 8 is conserved; (v) SEQ ID NO: 5 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif LADGVEGYLRASEASRDRVE (SEQ ID NO: 8) is conserved and preferably SEQ ID NO: 8 is conserved; or (vi) SEQ ID NO: 6 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif LADGVEGYLRASEASRDRVE (SEQ ID NO: 8) is conserved and preferably SEQ ID NO: 8 is conserved.

To provide a hair washing composition which has good foamability and foam retention, can be washed without a squeaky feeling, suppresses a slimy feeling, can easily wash away stains such as oil, and can impart moderate smoothness to hair after hair washing.SOLUTION: Wherein a total amount of a content of the ingredient A and a content of the ingredient B (ingredient A+ ingredient B) is 10 to 20% by mass in 100% by mass of the composition, and a mass content ratio of the content of the ingredient A to the content of the ingredient B (ingredient A / ingredient B) satisfies a range of 0.5 to 2.SELECTED DRAWING: None

To provide a hair detergent composition in which an amino acid-based surfactant is formulated, and which is excellent in storage stability and smoothness during shampooing while further containing an oily component.SOLUTION: The hair detergent composition comprises (A) an amino acid-based anionic surfactant, (B) a specific cationic polymer, (C) a hydrophobic amphiphile which is one or more kinds selected from the group consisting of a monofatty acid glyceryl (C1), a fatty acid (C2) and a higher alcohol (C3), and (D) an oily ingredient which is liquid at 25 °C, wherein the content of the ingredient (A) is 2.0 mass% or more.SELECTED DRAWING: None

The present invention relates to the technical field of scale and corrosion inhibitors, and discloses a preparation process of a neutral amino acid-based scale and corrosion inhibitor. The present invention reacts 3,5-dihydroxybenzaldehyde, taurine, epichlorohydrin, and N,N,N',N'-tetramethylethylenediamine to obtain a scale and corrosion inhibitor. The sulfonate and hydroxyl groups contained in the scale and corrosion inhibitor form stable chelates with barium ions and strontium ions, which can prevent the barium ions and strontium ions from combining with anions such as sulfate to form insoluble precipitates such as barium sulfate and strontium sulfate, thereby achieving excellent scale inhibition performance. The scale and corrosion inhibitor contains multiple active coordination centers of quaternary ammonium salt cations, sulfonate, and hydroxyl groups, which interact with the surface of a steel sheet to form a tight and firm protective film on the surface, preventing corrosive media such as hydrochloric acid from contacting the steel sheet, achieving excellent anti-corrosion and corrosion inhibition performance at high temperatures, and has good practical applications in oil field water injection and oil production.

The invention discloses a medicine carrying device for forming an in-situ intravascular stent and a preparation method. The medicine carrying device comprises an interventional instrument and a medicine coating covering the surface of the interventional instrument; the raw materials of the drug coating comprise a photoactive cross-linking agent and amino acid polyethylene glycol, and the mass ratio of the photoactive cross-linking agent to the amino acid polyethylene glycol is (0.5-2.5): 1; the photoactive cross-linking agent is selected from at least one of a naphthalimide derivative, rose bengal and riboflavin phosphate; the molecular weight of the amino acid polyethylene glycol is 1000-20000, and the amino acid group contained in the amino acid polyethylene glycol corresponds to at least one of tyrosine, tryptophan, histidine, lysine, arginine, methionine and cysteine. According to the medicine carrying device for forming the in-situ intravascular stent, after amino acid polyethylene glycol is added, amino acid residues at the two ends are subjected to light activation, protein which is not adjacent to the position of a vascular wall is also subjected to crosslinking, and a natural intravascular stent with denser fibers is formed through crosslinking.

The present invention relates to a method of treating or preventing neuropathology induced or associated with Porphyromonas gingivalis using a chimeric or fusion protein comprising a first polypeptide linked to a second polypeptide, wherein: A) the first polypeptide comprises or consists of the following: an amino acid sequence of an active site of Arg gingival protease or Lys gingival protease of Porphyromonas gingivalis, or a sequence at least 80% identical thereto; and B) the second polypeptide comprises or consists of the amino acid sequence of the adhesin domain of the Arg gingival protease or Lys gingival protease of Porphyromonas gingivalis; wherein the second polypeptide comprises one or more sequences of an adhesin binding motif (ABM), and wherein the second polypeptide: a) does not comprise: a sequence of a cleaved adhesin domain (CAD) or a portion thereof; and / or b) comprising an amino acid sequence substantially corresponding to the full length of the DUF2436 domain of the Arg gingival protease or Lys gingival protease; and / or c) comprises one or more cysteine amino acid substitutions in the adhesin domain as compared to the naturally occurring Arg gingival protease or Lys gingival protease sequence in the corresponding region, and / or d) comprises one or more additional amino acid motif substitutions as defined herein.

In accordance with an exemplary aspect of the invention, there is provided a modified Ara h 2 peanut allergen polypeptide wherein at least one of the wild-type DPYSPS amino acid motifs in the polypeptide comprises a first amino acid substitution at motif 3 and a second amino acid substitution at motif 5 wherein the proline (P) at motif 5 is a hydroxyproline residue, and wherein at least one of the wild-type DPYSPS amino acid motifs in the polypeptide comprises a first amino acid substitution at motif 3 and a second amino acid substitution at motif 5 is a hydroxyproline residue. Wherein the modified Ara h 2 peanut allergen polypeptide is a mutant of a peanut allergen polypeptide Ara h 2.0201 comprising three DPYSPS amino acid motifs, or a mutant of a peanut allergen polypeptide Ara h 2.0101 comprising two DPYSPS amino acid motifs, and wherein the amino acid sequence outside the DPYSPS motifs has at least 90% sequence identity with the Ara h 2.0201 or Ara h 2.0101 sequence.