39 results about "AMINO BASE" patented technology

The present invention relates to a solid laundry composition. More particularly it relates to a solid laundry composition which provides improved fragrance perception. It is desired to provide solid laundry composition which provides improved fragrance intensity on wet fabrics, also preferably on both wet fabrics and post drying the fabrics. The present inventors have found that when a solid laundry composition has a surfactant system comprising alkyl aryl sulphonate surfactant and an amino acid-based surfactant in combination with specific chelating agents it provides for surprisingly higher fragrance intensity, preferably on wet fabrics, more preferably both on the wet fabrics and after drying the fabrics. It was also found that the composition according to the first aspect of the present invention provides for reducing / removing the malodour producing soil from the fabrics.

The invention belongs to the technical field of polyurethane, and particularly relates to bio-based flame-retardant polyurethane polystyrene foam. The bio-based flame-retardant polyurethane polystyrene foam is prepared from the following raw materials in parts by weight: 60 to 75 parts of amino acid-based modified polyether polyol; 25-40 parts of a nitrogen and phosphorus-containing hydroxyl-terminated modified polymer; 380 to 440 parts of modified isocyanate; 100 to 130 parts of chlorinated paraffin; 40 to 60 parts of filler; 8-10 parts of silicone oil; 80 to 100 parts of a propellant; and 3-5 parts of a catalyst. Bio-based raw materials such as castor oil and amino acid are introduced into the molecular structure of the polyurethane polystyrene foam through chemical modification, so that the biodegradability of the material is improved; a proper polymeric monomer is screened, and a flame-retardant element chlorine is introduced into a polyether molecular structure through chemical polymerization and forms multi-element synergy with nitrogen and phosphorus elements bridged through ester bonds, so that the content of the flame-retardant element in the polystyrene foam material is effectively increased, and the flame retardance is improved.

To provide a composition for hair capable of improving the volume of hair while suppressing the entanglement of hair, and to provide a hair treatment method using the composition for hair.SOLUTION: This composition for the hair is obtained by formulating (A) an amino acid-based cationic surface active agent with (B) one or more kinds selected from pantothenic acids, vitamin C or its salts, vitamin B3 or its salts and vitamin B6 or its salts. The hair treatment method uses the composition for hair.SELECTED DRAWING: None

The present application relates to the technical field of compound synthesis, and in particular to a preparation method of amino acid-based lactam, comprising: A) reacting an alpha-amino acid and an alpha-hydroxy acid ester in a first solvent under the action of a first catalyst to obtain N-(hydroxyacyl)-amino acid ester; B) reacting the N-(hydroxyacyl)-amino acid ester in a second solvent under the action of a second catalyst to obtain amino acid-based lactam with a structure shown in Formula I; in Formula I, R1 and R2 are independently selected from one of hydrogen, a C1-C4 straight-chain or branched-chain aliphatic hydrocarbon group, a substituted or unsubstituted C6-C30 aryl group, a protected amino group, a protected carboxyl group, a protected hydroxyl group and a protected sulfydryl group; and the protecting group is one of an alkoxycarbonyl group, an acyl group and an alkyl group. The present application can solve the problems in the existing lactam synthesis process, such as high raw material risk, complicated process, and difficult product purification.

The invention relates to a cell attachment peptide containing an RGD amino acid motif, characterized by a material-side motif derived from poly-L-lysine and a cell-side motif derived from vitronectin. The peptide may be used to functionalize materials for use in cell cultures, such as microcarriers, scaffolds, and substrates.

The invention discloses a design method of rare earth-amino acid based multifunctional hydrogel. The hydrogel takes polyacrylamide-co-poly (2-acrylamide-2-methylpropanesulfonic acid) as a matrix and comprises the following components: polyvinyl alcohol, acrylamide, 2-acrylamide-2-methylpropanesulfonic acid, threonine, europium nitrate hexahydrate and terbium nitrate hexahydrate, and the formed amino acid-based hydrogel is doped with rare earth ions (such as europium ions and terbium ions). The hydrogel has fluorescent and conductive dual sensing channels, and rare earth-amino acid is used for physical crosslinking, so that a stronger cross-linked network is provided, and the mechanical property is enhanced; meanwhile, the hydrogel can freely adjust the mechanical property and the fluorescence intensity by changing the amino acid content, responds to the external ion environment, and has high sensing sensitivity (GF = 7.07) and tensile property (strain = 780%). The hydrogel sensor is stable in performance and convenient to prepare, the application range of the rare earth hydrogel is widened, and the hydrogel sensor has a good development prospect.

To provide a hair washing composition which has good foamability and foam retention, can be washed without a squeaky feeling, suppresses a slimy feeling, can easily wash away stains such as oil, and can impart moderate smoothness to hair after hair washing.SOLUTION: Wherein a total amount of a content of the ingredient A and a content of the ingredient B (ingredient A+ ingredient B) is 10 to 20% by mass in 100% by mass of the composition, and a mass content ratio of the content of the ingredient A to the content of the ingredient B (ingredient A / ingredient B) satisfies a range of 0.5 to 2.SELECTED DRAWING: None

To provide a hair detergent composition in which an amino acid-based surfactant is formulated, and which is excellent in storage stability and smoothness during shampooing while further containing an oily component.SOLUTION: The hair detergent composition comprises (A) an amino acid-based anionic surfactant, (B) a specific cationic polymer, (C) a hydrophobic amphiphile which is one or more kinds selected from the group consisting of a monofatty acid glyceryl (C1), a fatty acid (C2) and a higher alcohol (C3), and (D) an oily ingredient which is liquid at 25 °C, wherein the content of the ingredient (A) is 2.0 mass% or more.SELECTED DRAWING: None

The present invention relates to a method of treating or preventing neuropathology induced or associated with Porphyromonas gingivalis using a chimeric or fusion protein comprising a first polypeptide linked to a second polypeptide, wherein: A) the first polypeptide comprises or consists of the following: an amino acid sequence of an active site of Arg gingival protease or Lys gingival protease of Porphyromonas gingivalis, or a sequence at least 80% identical thereto; and B) the second polypeptide comprises or consists of the amino acid sequence of the adhesin domain of the Arg gingival protease or Lys gingival protease of Porphyromonas gingivalis; wherein the second polypeptide comprises one or more sequences of an adhesin binding motif (ABM), and wherein the second polypeptide: a) does not comprise: a sequence of a cleaved adhesin domain (CAD) or a portion thereof; and / or b) comprising an amino acid sequence substantially corresponding to the full length of the DUF2436 domain of the Arg gingival protease or Lys gingival protease; and / or c) comprises one or more cysteine amino acid substitutions in the adhesin domain as compared to the naturally occurring Arg gingival protease or Lys gingival protease sequence in the corresponding region, and / or d) comprises one or more additional amino acid motif substitutions as defined herein.

In accordance with an exemplary aspect of the invention, there is provided a modified Ara h 2 peanut allergen polypeptide wherein at least one of the wild-type DPYSPS amino acid motifs in the polypeptide comprises a first amino acid substitution at motif 3 and a second amino acid substitution at motif 5 wherein the proline (P) at motif 5 is a hydroxyproline residue, and wherein at least one of the wild-type DPYSPS amino acid motifs in the polypeptide comprises a first amino acid substitution at motif 3 and a second amino acid substitution at motif 5 is a hydroxyproline residue. Wherein the modified Ara h 2 peanut allergen polypeptide is a mutant of a peanut allergen polypeptide Ara h 2.0201 comprising three DPYSPS amino acid motifs, or a mutant of a peanut allergen polypeptide Ara h 2.0101 comprising two DPYSPS amino acid motifs, and wherein the amino acid sequence outside the DPYSPS motifs has at least 90% sequence identity with the Ara h 2.0201 or Ara h 2.0101 sequence.

In some aspects, the present disclosure provides engineered adeno-associated virus (AAV) capsid proteins comprising a non-naturally occurring amino acid motif described herein. In some embodiments, the present disclosure provides an AAV9, AAV5, AAVrh.10 or AAVrh.74-based engineered capsid protein, that when assembled into virions, achieves increased transduction efficiency of the heart, and / or other desirable properties. Also provided herein are recombinant AAV virions comprising any of the engineered capsid proteins described herein and uses thereof.

Provided are: an agent for improving the resident flora balance of skin and / or a mucous membrane, the agent containing at least one component selected from the group consisting of component (A) and component (B); and a method for improving the resident flora balance by applying, to the skin and / or a mucous membrane, a composition containing at least one component selected from the group consisting of component (A) and component (B).　(A) At least one selected from the group consisting of hyaluronic acid, derivatives of hyaluronic acid, and salts thereof (B) At least one selected from the group consisting of nonionic surfactants and amino acid-based surfactants

Disclosed are a method for preparing a Schiff base-modified ionic framework material and use thereof in advanced purification of 177Lu-containing medical wastewater, including: using a conventional sponge as a substrate material and employing the Schiff base reaction principle with an amine-based reagent as a “bridge” and an aldehyde-based reagent as an active excitation reaction monomer to prepare an amino acid-based metal ionic Schiff base-modified ionic framework material by a one-pot synthesis method; and packing the Schiff base-modified ionic framework material in a chromatographic column for the advanced purification of the 177Lu-containing medical wastewater. The material preparation process of this disclosure is simple with stable performance, and the functionalized modified material possesses ion exchange functionality, exhibiting superior adsorption performance for metal cations. Furthermore, the combined process method of this disclosure demonstrates good treatment effects on the 177Lu-containing medical wastewater.

Antimicrobial compositions comprising at least an amine based antimicrobial agent and an alkanolamine are disclosed. The disclosed compositions may be free of quaternary ammonium compounds. The disclosed compositions have antimicrobial properties and fast efficacy against yeasts and bacteria.

The invention relates to the technical field of medical / health-care patches, and discloses a detoxification plaster and a preparation method thereof, the detoxification plaster is composed of a backing layer, a plaster layer and an anti-sticking layer, and the plaster layer comprises Chinese herbal medicinal ingredients such as wormwood and poria cocos and auxiliary materials such as amino acid-based polymer and nano-silver particles. Traditional Chinese medicine effective components are extracted through water decoction and mixed with a hot-melt pressure-sensitive adhesive and the like for paste spreading. The plaster solves the problems that an existing product is unstable in component, poor in adhesion, single in effect and the like, has the effects of detoxifying, resisting bacteria and relieving, and is good in viscosity, convenient to use and suitable for batch production.

The invention relates to a specific small molecule compound of a GLYR1 target spot and application thereof, and belongs to the field of biological medicine. The invention provides a small molecule compound C20H32O5, which is specifically combined with 27185-285amino acid motifs of glyoxylate reductase homologue-1 (GLYR1) protein, so that the combining capacity of the GLYR1 and chromosome DNA in a cell nucleus is reduced, and gene transcription is inhibited; meanwhile, the retention of GLYR1 in cytoplasm is prolonged, and the phosphorylation levels of ERK and MAPK are reduced, so that the transcription up-regulation of proinflammatory cytokines in macrophages is inhibited. The compound rapidly inhibits inflammatory storm caused by coronavirus infection, and significantly reduces severe illness and death risks; experiments prove that the survival rate in an SARS-CoV-2 infected mouse model is increased to 100% from 63.5%, the survival rate in an MHV-3 infected model is remarkably increased, and tissue pathological injuries of lungs and spleens are relieved.

The present invention addresses the problem of providing a method for reducing cracks and sweating in a transparent solid composition containing an amino acid-based gelling agent. Provided are: a transparent solid cosmetic comprising an amino acid-based gelling agent and a fatty acid ester having a C3 or higher hydrocarbon side chain; a premix for preparing the cosmetic; and a method for reducing cracking and sweating, the method comprising blending a fatty acid ester having a C3 or higher hydrocarbon side chain into the transparent solid cosmetic containing an amino acid-based gelling agent.

The utility model discloses an amino acid base stock storage tank with a cooling mechanism, which comprises a tank body, one side of the tank body is provided with a water tank, the bottom of the water tank is fixedly connected with a water pump, the water pump is communicated with the water tank through a communicating pipe, one side of the water pump is communicated with a conveying pipe, and the cooling mechanism is started by starting the water pump. Water in the water tank is conveyed into the conveying pipe through the communicating pipe, then the water is conveyed into the annular pipe through the conveying pipe, then the water is sprayed to the surface of the tank body through the spray head to be cooled, and the sprayed water flows into the collecting tank through the tank body and is conveyed into the filtering tank through the water conveying pipe. After being filtered by the first filter screen, the second filter screen and the third filter screen, water flows into the water tank again through the through holes to form circulation, and after being used for a long time, the three filter screens are sequentially disassembled, assembled and cleaned through the fixing mechanisms, so that the circulating water in the cooling process can be filtered, and the cooling effect is improved. Therefore, the spray holes are prevented from being blocked.

The application discloses a luminescent oligopeptide based on natural amino acids and a preparation method and application in a biological system fluorescent probe and a virtual screening method thereof. The amino acid sequence of the luminescent oligopeptide is proline-tyrosine-tryptophan or proline-tryptophan-asparagine. The preparation method adopts a solid-phase synthesis method. The virtual screening method comprises the following steps: constructing a dipeptide structure library by using 22 kinds of natural amino acids, taking the time-dependent density functional theory as a calculation method, comparing and calculating by using two kinds of functionals, namely, omegaB97XD and B3LYP-D3, screening an excellent dipeptide in optical performance, inserting an amino acid element at any position of the dipeptide to construct a tripeptide structure library, performing quantitative calculation, screening a target tripeptide structure with a narrow band gap and strong oscillator strength, and taking the target tripeptide structure as a luminescent oligopeptide candidate based on natural amino acids.

The invention relates to the technical field of antibacterial gels, and discloses a vagina internal environment-imitating antibacterial gel, which is prepared by the following steps: S1, sufficiently swelling a phase A for later use at normal temperature; s2, fully dissolving the phase B, adding the phase A, and uniformly stirring; and S3, fully stirring and dissolving the phase C, the phase D and the phase E, adding the mixed phase in the S2, stirring, uniformly stirring, standing or defoaming under negative pressure, and filling. The radix sophorae flavescentis extract has the effects of resisting bacteria, diminishing inflammation, relieving itching, easing pain and improving the vaginal environment on the vagina, the peony root bark extract has the effects of resisting inflammation, resisting oxidation and improving skin health on the vagina, and the fructus cnidii extract can relieve pudendum wet itching and the like on the vagina; chitosan contained in the quaternized amino acid has the effects of promoting healing of the vagina and improving the vagina environment, meanwhile, the chitosan and quaternary ammonium salt in the quaternized amino acid jointly have the sterilization effect, and an amino acid group in the quaternized amino acid has the moisturizing effect.

The present invention relates an improved sequesterant composition in powder or granule form comprising HEDP and an amino acid based sequesterant selected from the group of MGDA and GLDA. In other aspects, the invention relates to a method for the preparation of said compositions as well as their use in cleaning products.

This application discloses a functional breathable PVDC resin composition comprising PVDC resin and an amino acid-modified polycarboxylate; the amino acid-modified polycarboxylate comprises at least one compound represented by Formula I: Formula I, wherein: R1-N- is an amino acid group; R2 and R3 are each independently selected from C4-C12 straight-chain alkylene or C4-C12 branched alkylene, and the total number of carbon atoms in R2 and R3 is less than 18; M1 and M2 each independently comprise Na + K + or Ca 2+ The functional breathable PVDC resin composition of this application can significantly improve the interaction between carboxylate and carbon dioxide, ultimately achieving multi-site absorption of CO2 by amine and carboxylate groups in PVDC resin, increasing the solubility of carbon dioxide in PVDC membrane, and thus increasing the carbon dioxide permeability, resulting in a higher CO2 permeability / O2 permeability ratio.

The present invention relates to a solid laundry composition. More particularly it relates to a solid laundry composition which provides improved fragrance perception. It is desired to provide solid laundry composition which provides improved fragrance intensity on wet fabrics, also preferably on both wet fabrics and post drying the fabrics. The present inventors have found that when a solid laundry composition has a surfactant system comprising alkyl aryl sulphonate surfactant and an amino acid-based surfactant in combination with aminopolycarboxylate or salt thereof it provides for surprisingly higher fragrance intensity, preferably on wet fabrics, more preferably both on the wet fabrics and after drying the fabrics. It was also found that the composition according to the first aspect of the present invention provides for reducing / removing the malodour producing soil from the fabrics.

The present invention relates to a solid laundry composition. More particularly it relates to a solid laundry composition which provides improved fragrance perception. It is desired to provide solid laundry composition which provides improved fragrance intensity on wet fabrics, also preferably on both wet fabrics and post drying the fabrics. The present inventors have found that when a solid laundry composition has a surfactant system comprising 0 wt.% to 2.5 wt.% alkyl aryl sulphonate surfactant and an amino acid-based surfactant in combination with specific chelating agent it provides for surprisingly higher fragrance intensity, preferably on wet fabrics, more preferably both on the wet fabrics and after drying the fabrics. It was also found that the composition according to the first aspect of the present invention provides for reducing / removing the malodour producing soil from the fabrics. It was further found that the solid laundry composition according to the first aspect of the present invention provides for improving the cleaning performance on the fabrics even when the composition comprises minimal, or no petroleum derived anionic surfactant.

The application discloses a kind of production phycobilisome amino acid Porphyra-334 genetically engineered glutamic acid coryneform bacteria and application thereof, belong to microbial genetic engineering and fermentation technical field.The application uses glutamic acid coryneform bacteria ATCC 13032 as host strain, by knocking out competitive pathway gene, in genome multiple copy source from Nostoc linckia NIES-25 for synthesizing Porphyra-334 four key synthesis pathway enzyme genes, knocking out acid-producing pathway gene and threonine dehydrase gene in strain to realize the improvement of synthesis Porphyra-334 yield.Finally, genetically engineered strain produces Porphyra-334 in shake flask, and can accumulate 1.23 g / L in 72 h.In 50L fermenter, fed-batch fermentation is expanded in culture, and finally can reach 7.08 g / L.

This invention provides an integrated method for producing multi-stage functionalized humic products using an amino acid-based deep eutectic solvent, belonging to the field of high-value utilization of biomass resources. The method uses a specific amino acid combined with a weak acid to form an amino acid-based deep eutectic solvent, which is then used for ultrasonic pretreatment and controlled hydrothermal reaction of biomass raw materials. Through natural cooling combined with pH gradient fractional precipitation, high-molecular-weight humic acid A, suitable for soil improvement, and low-molecular-weight, highly water-soluble humic acid B, suitable for foliar fertilizer, are obtained. Rapid cooling and concentration yield a highly bioactive fulvic acid concentrate. This invention achieves the targeted conversion and precise separation of a single biomass raw material into multiple functional humic acid products, significantly increasing the nitrogen content of the products. Furthermore, the amino acid-based deep eutectic solvent can be efficiently recycled, combining high efficiency, environmental friendliness, and high value.

The present application belongs to the technical field of polyurethane, and particularly relates to a bio-based flame-retardant polyurethane foaming adhesive. The bio-based flame-retardant polyurethane foaming adhesive is composed of the following raw materials in parts by weight: amino acid-based modified polyether polyol: 60-75 parts; nitrogen and phosphorus-containing hydroxyl-terminated modified polymer: 25-40 parts; modified isocyanate: 380-440 parts; chlorinated paraffin: 100-130 parts; filler: 40-60 parts; silicone oil: 8-10 parts; propellant: 80-100 parts; catalyst: 3-5 parts. By introducing bio-based raw materials such as castor oil and amino acid into the molecular structure of the polyurethane foaming adhesive through chemical modification, the biodegradability of the material is improved; by screening suitable polymer monomers, the flame-retardant element-chlorine is introduced into the polyether molecular structure through chemical polymerization, and the nitrogen and phosphorus elements are bridged through ester bonds to form a multi-element synergy, effectively increasing the content of the flame-retardant element in the foaming adhesive material and improving the flame retardancy.

The present disclosure relates to synthesizing and utilizing fluorescent dye compounds or pharmaceutically acceptable salts thereof. Conjugation of amino acid groups to the fluorescent dyes increase specificity and detection of the compound. Methods of manufacture and synthesis of the compounds for use thereof in diagnostic imaging are contemplated.

The invention provides an elastic and collagen fused recombinant protein as well as a preparation method and application thereof, and belongs to the technical field of bioengineering and protein engineering. The recombinant protein is a fusion functional protein formed by fusing at least one collagen at the N end and the C end of elastin-like protein respectively; the amino acid sequence of the elastin-like protein is a tandem repeat of a basic unit (VPGXG) n, X is selected from natural amino acids except proline, and the repeat number n of the basic unit is 40-60; the collagen is selected from human-derived collagen I, collagen III, collagen IV, collagen V, collagen VI, collagen VII or collagen XVII. The recombinant protein is prepared by adopting an elastin-like double-end fusion collagen technology, so that the soluble expression of the fusion protein can be realized, the fusion protein and the double-end fusion protein can generate a synergistic effect, the migration and adhesion of fibroblasts can be remarkably promoted, and the cell toxicity is avoided. In-vivo experiments prove that the wound healing of mice can be effectively accelerated, and the risk of wound infection is reduced.

The present application relates to a kind of preparation method of amino acid-based polyester amide / polyglycolide fiber membrane.The fiber membrane is that protein-based hypoglycemic drug is added to 0.2~0.5g / ml amino acid-based polyester amide solution to obtain drug-loaded nanocomposite, then is added to 0.2~0.5g / ml polyglycolide solution, is prepared by electrospinning technology, wherein the volume ratio of amino acid-based polyester amide drug-loaded nanocomposite polyglycolide solution is 0.5~2:5.The fiber membrane of the present application has very high porosity, has good adhesion when implanted into patient's body, prevents the risk of postoperative adhesion, can effectively promote the rapid healing of postoperative wound of diabetic patients;In addition, the preparation method of the fiber membrane is simple, has good application in the preparation of diabetic wound repair material.