57 results about "AMINO BASE" patented technology

The present invention relates to a solid laundry composition. More particularly it relates to a solid laundry composition which provides improved fragrance perception. It is desired to provide solid laundry composition which provides improved fragrance intensity on wet fabrics, also preferably on both wet fabrics and post drying the fabrics. The present inventors have found that when a solid laundry composition has a surfactant system comprising alkyl aryl sulphonate surfactant and an amino acid-based surfactant in combination with specific chelating agents it provides for surprisingly higher fragrance intensity, preferably on wet fabrics, more preferably both on the wet fabrics and after drying the fabrics. It was also found that the composition according to the first aspect of the present invention provides for reducing / removing the malodour producing soil from the fabrics.

The invention belongs to the technical field of polyurethane, and particularly relates to bio-based flame-retardant polyurethane polystyrene foam. The bio-based flame-retardant polyurethane polystyrene foam is prepared from the following raw materials in parts by weight: 60 to 75 parts of amino acid-based modified polyether polyol; 25-40 parts of a nitrogen and phosphorus-containing hydroxyl-terminated modified polymer; 380 to 440 parts of modified isocyanate; 100 to 130 parts of chlorinated paraffin; 40 to 60 parts of filler; 8-10 parts of silicone oil; 80 to 100 parts of a propellant; and 3-5 parts of a catalyst. Bio-based raw materials such as castor oil and amino acid are introduced into the molecular structure of the polyurethane polystyrene foam through chemical modification, so that the biodegradability of the material is improved; a proper polymeric monomer is screened, and a flame-retardant element chlorine is introduced into a polyether molecular structure through chemical polymerization and forms multi-element synergy with nitrogen and phosphorus elements bridged through ester bonds, so that the content of the flame-retardant element in the polystyrene foam material is effectively increased, and the flame retardance is improved.

To provide a composition for hair capable of improving the volume of hair while suppressing the entanglement of hair, and to provide a hair treatment method using the composition for hair.SOLUTION: This composition for the hair is obtained by formulating (A) an amino acid-based cationic surface active agent with (B) one or more kinds selected from pantothenic acids, vitamin C or its salts, vitamin B3 or its salts and vitamin B6 or its salts. The hair treatment method uses the composition for hair.SELECTED DRAWING: None

The invention provides a water-based composite electrolyte and a preparation method and application thereof. The water-based composite electrolyte comprises soluble zinc salt, amino acid hydrochloride additives and deionized water. The aqueous composite electrolyte can be used for a symmetrical button cell, a half cell or an aqueous zinc ion total cell. By adjusting zinc ion deposition on the surface of the zinc electrode, the growth of zinc dendrites is reduced, and the shuttle effect of the iodine positive electrode is inhibited, so that the coulombic efficiency and the cycle performance of the water-based zinc-iodine battery are improved. The additive disclosed by the invention can be adsorbed on the surface of a zinc negative electrode, delays the nucleation process and inhibits the growth of zinc dendrites; the form of hydrochloride can play a role of a buffer solution, stabilize the pH value of the electrolyte, inhibit the corrosion of the zinc negative electrode and reduce the hydrogen evolution reaction; the hydrochloride form can weaken the protonation effect of amino acid groups and enhance the electrostatic interaction between the amino acid groups and the polyiodide, so that the shuttle effect is inhibited, and the coulombic efficiency and the cycle performance of the aqueous zinc-iodine battery are improved.

To provide a method for reducing cracks in transparent solid compositions containing amino acid-based gelling agents.SOLUTION: The present invention provides a method for reducing cracks, including blending a dimer diol and / or a glycerin fatty acid ester with a transparent solid cosmetic preparation containing an amino acid-based gelling agent; a transparent solid cosmetic preparation containing an amino acid-based gelling agent and a dimer diol and / or a glycerin fatty acid ester; and a premix for preparing such a cosmetic preparation.SELECTED DRAWING: Figure 4

The present application relates to the technical field of compound synthesis, and in particular to a preparation method of amino acid-based lactam, comprising: A) reacting an alpha-amino acid and an alpha-hydroxy acid ester in a first solvent under the action of a first catalyst to obtain N-(hydroxyacyl)-amino acid ester; B) reacting the N-(hydroxyacyl)-amino acid ester in a second solvent under the action of a second catalyst to obtain amino acid-based lactam with a structure shown in Formula I; in Formula I, R1 and R2 are independently selected from one of hydrogen, a C1-C4 straight-chain or branched-chain aliphatic hydrocarbon group, a substituted or unsubstituted C6-C30 aryl group, a protected amino group, a protected carboxyl group, a protected hydroxyl group and a protected sulfydryl group; and the protecting group is one of an alkoxycarbonyl group, an acyl group and an alkyl group. The present application can solve the problems in the existing lactam synthesis process, such as high raw material risk, complicated process, and difficult product purification.

The invention discloses a hydrogen-bond-rich bionic artificial alpha-amino-acid-based anthraquinone derivative and a preparation method and application thereof in an aqueous flow battery, and relates to the technical field of electrochemical energy storage. 1, 5-DHAQ and a methanol solution are added into a flask, KOH is added, NaS2O4 is added into the mixture in an ice-water bath, a formaldehyde solution is added after color change, an H2O2 aqueous solution is added after 12 h, hydrochloric acid is used for acidification, and the hydrogen-bond-rich bionic artificial alpha-amino-acid-based anthraquinone derivative is obtained. Washing and drying the precipitate; the preparation method comprises the following steps: adding 2, 4, 6-trichlorotriazine into DMF (Dimethyl Formamide), stirring to generate a white solid, adding dichloromethane and sodium bromide, stirring, adding 1, 5-dihydroxy-2, 6-bis (hydroxymethyl) anthracene-9, 10-diketone, washing with a Na2CO3 solution, washing with HCl, drying, adding 2, 6-bis (bromomethyl)-1, 5-dihydroxyanthracene-9, 10-diketone and cysteine into KOH, stirring at 60 DEG C overnight, and pickling to obtain Cys-DHAQ.

The invention relates to a cell attachment peptide containing an RGD amino acid motif, characterized by a material-side motif derived from poly-L-lysine and a cell-side motif derived from vitronectin. The peptide may be used to functionalize materials for use in cell cultures, such as microcarriers, scaffolds, and substrates.

Substituted 5-membered ring molecules substituted with fluorinated benzyl and amino acid groups having formula (I), and derivatives thereof, are disclosed herein. The substituted 5-membered ring molecules have herbicidal activity and can be used to control undesirable vegetation. Compositions, methods of making, and methods of controlling undesirable vegetation using substituted 5-membered ring molecules are also disclosed.

The invention discloses a design method of rare earth-amino acid based multifunctional hydrogel. The hydrogel takes polyacrylamide-co-poly (2-acrylamide-2-methylpropanesulfonic acid) as a matrix and comprises the following components: polyvinyl alcohol, acrylamide, 2-acrylamide-2-methylpropanesulfonic acid, threonine, europium nitrate hexahydrate and terbium nitrate hexahydrate, and the formed amino acid-based hydrogel is doped with rare earth ions (such as europium ions and terbium ions). The hydrogel has fluorescent and conductive dual sensing channels, and rare earth-amino acid is used for physical crosslinking, so that a stronger cross-linked network is provided, and the mechanical property is enhanced; meanwhile, the hydrogel can freely adjust the mechanical property and the fluorescence intensity by changing the amino acid content, responds to the external ion environment, and has high sensing sensitivity (GF = 7.07) and tensile property (strain = 780%). The hydrogel sensor is stable in performance and convenient to prepare, the application range of the rare earth hydrogel is widened, and the hydrogel sensor has a good development prospect.

To provide a hair washing composition which has good foamability and foam retention, can be washed without a squeaky feeling, suppresses a slimy feeling, can easily wash away stains such as oil, and can impart moderate smoothness to hair after hair washing.SOLUTION: Wherein a total amount of a content of the ingredient A and a content of the ingredient B (ingredient A+ ingredient B) is 10 to 20% by mass in 100% by mass of the composition, and a mass content ratio of the content of the ingredient A to the content of the ingredient B (ingredient A / ingredient B) satisfies a range of 0.5 to 2.SELECTED DRAWING: None

To provide a hair detergent composition in which an amino acid-based surfactant is formulated, and which is excellent in storage stability and smoothness during shampooing while further containing an oily component.SOLUTION: The hair detergent composition comprises (A) an amino acid-based anionic surfactant, (B) a specific cationic polymer, (C) a hydrophobic amphiphile which is one or more kinds selected from the group consisting of a monofatty acid glyceryl (C1), a fatty acid (C2) and a higher alcohol (C3), and (D) an oily ingredient which is liquid at 25 °C, wherein the content of the ingredient (A) is 2.0 mass% or more.SELECTED DRAWING: None

The present invention relates to the technical field of scale and corrosion inhibitors, and discloses a preparation process of a neutral amino acid-based scale and corrosion inhibitor. The present invention reacts 3,5-dihydroxybenzaldehyde, taurine, epichlorohydrin, and N,N,N',N'-tetramethylethylenediamine to obtain a scale and corrosion inhibitor. The sulfonate and hydroxyl groups contained in the scale and corrosion inhibitor form stable chelates with barium ions and strontium ions, which can prevent the barium ions and strontium ions from combining with anions such as sulfate to form insoluble precipitates such as barium sulfate and strontium sulfate, thereby achieving excellent scale inhibition performance. The scale and corrosion inhibitor contains multiple active coordination centers of quaternary ammonium salt cations, sulfonate, and hydroxyl groups, which interact with the surface of a steel sheet to form a tight and firm protective film on the surface, preventing corrosive media such as hydrochloric acid from contacting the steel sheet, achieving excellent anti-corrosion and corrosion inhibition performance at high temperatures, and has good practical applications in oil field water injection and oil production.

The present invention relates to a method of treating or preventing neuropathology induced or associated with Porphyromonas gingivalis using a chimeric or fusion protein comprising a first polypeptide linked to a second polypeptide, wherein: A) the first polypeptide comprises or consists of the following: an amino acid sequence of an active site of Arg gingival protease or Lys gingival protease of Porphyromonas gingivalis, or a sequence at least 80% identical thereto; and B) the second polypeptide comprises or consists of the amino acid sequence of the adhesin domain of the Arg gingival protease or Lys gingival protease of Porphyromonas gingivalis; wherein the second polypeptide comprises one or more sequences of an adhesin binding motif (ABM), and wherein the second polypeptide: a) does not comprise: a sequence of a cleaved adhesin domain (CAD) or a portion thereof; and / or b) comprising an amino acid sequence substantially corresponding to the full length of the DUF2436 domain of the Arg gingival protease or Lys gingival protease; and / or c) comprises one or more cysteine amino acid substitutions in the adhesin domain as compared to the naturally occurring Arg gingival protease or Lys gingival protease sequence in the corresponding region, and / or d) comprises one or more additional amino acid motif substitutions as defined herein.

In accordance with an exemplary aspect of the invention, there is provided a modified Ara h 2 peanut allergen polypeptide wherein at least one of the wild-type DPYSPS amino acid motifs in the polypeptide comprises a first amino acid substitution at motif 3 and a second amino acid substitution at motif 5 wherein the proline (P) at motif 5 is a hydroxyproline residue, and wherein at least one of the wild-type DPYSPS amino acid motifs in the polypeptide comprises a first amino acid substitution at motif 3 and a second amino acid substitution at motif 5 is a hydroxyproline residue. Wherein the modified Ara h 2 peanut allergen polypeptide is a mutant of a peanut allergen polypeptide Ara h 2.0201 comprising three DPYSPS amino acid motifs, or a mutant of a peanut allergen polypeptide Ara h 2.0101 comprising two DPYSPS amino acid motifs, and wherein the amino acid sequence outside the DPYSPS motifs has at least 90% sequence identity with the Ara h 2.0201 or Ara h 2.0101 sequence.

In some aspects, the present disclosure provides engineered adeno-associated virus (AAV) capsid proteins comprising a non-naturally occurring amino acid motif described herein. In some embodiments, the present disclosure provides an AAV9, AAV5, AAVrh.10 or AAVrh.74-based engineered capsid protein, that when assembled into virions, achieves increased transduction efficiency of the heart, and / or other desirable properties. Also provided herein are recombinant AAV virions comprising any of the engineered capsid proteins described herein and uses thereof.

The invention relates to the technical field of traditional Chinese medicine preparation, and discloses a ganoderma spore coating technology which comprises the following steps: pretreating raw materials, selecting wall-broken ganoderma spore powder, placing in a vacuum treatment chamber, vacuumizing until the absolute pressure is less than 5Pa, maintaining for 10-30 minutes, and sterilizing by using a cobalt-60 irradiation source at the irradiation dose of 10-15kGy for 2-4 hours; preparing a coating solution, namely mixing edible gelatin, sodium alginate and functional polypeptide in proportion, and adding purified water for dissolving to form the coating solution; and fluidized bed coating. In the invention, the functional polypeptide and a gelatin-sodium alginate matrix form directional hydrogen bond combination through a hydrophilic amino acid group of the functional polypeptide, so as to trigger synergistic crosslinking of molecular chains of a coating layer and construct a continuous and compact three-dimensional network structure; the network further reinforces interpenetrating cross-linking through ionic bonds in the curing process to form a directional barrier for active ingredients of spores, so that erosion of the gastrointestinal environment is blocked, and slow release and targeted absorption of active substances are guaranteed.

The present invention provides a recombinant human type III collagen and a method for its construction. The recombinant human type III collagen comprises 468 amino acids, with a basic repeating unit of GERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGER. The recombinant human collagen of the present invention is 100% identical to the corresponding portion of the natural collagen gene sequence, has a triple-helical structure, and exhibits excellent hydrophilicity and stability. The production steps include: construction of genetically engineered Escherichia coli bacteria, fermentation and cultivation of the genetically engineered bacteria, and purification of the recombinant human collagen. The present invention does not cause immune rejection when used in the human body and can be widely used in biomedical materials, cosmetics, and other fields.

Provided are: an agent for improving the resident flora balance of skin and / or a mucous membrane, the agent containing at least one component selected from the group consisting of component (A) and component (B); and a method for improving the resident flora balance by applying, to the skin and / or a mucous membrane, a composition containing at least one component selected from the group consisting of component (A) and component (B).　(A) At least one selected from the group consisting of hyaluronic acid, derivatives of hyaluronic acid, and salts thereof (B) At least one selected from the group consisting of nonionic surfactants and amino acid-based surfactants

Disclosed are a method for preparing a Schiff base-modified ionic framework material and use thereof in advanced purification of 177Lu-containing medical wastewater, including: using a conventional sponge as a substrate material and employing the Schiff base reaction principle with an amine-based reagent as a “bridge” and an aldehyde-based reagent as an active excitation reaction monomer to prepare an amino acid-based metal ionic Schiff base-modified ionic framework material by a one-pot synthesis method; and packing the Schiff base-modified ionic framework material in a chromatographic column for the advanced purification of the 177Lu-containing medical wastewater. The material preparation process of this disclosure is simple with stable performance, and the functionalized modified material possesses ion exchange functionality, exhibiting superior adsorption performance for metal cations. Furthermore, the combined process method of this disclosure demonstrates good treatment effects on the 177Lu-containing medical wastewater.

A polyurethane sponge and its preparation method and application, relating to the field of medical material technology, solves the problems of poor biocompatibility, poor biodegradation effect, lack of antibacterial properties of traditional polyurethane materials, and decreased mechanical rigidity of existing amino acid-based polyurethane materials. The preparation steps of the present invention are: an amino acid compound containing a hydroxyl group in a side chain is prepared by a condensation reaction to obtain a chain extender amino acid cyclic dipeptide; polyethylene glycol is heated, vacuum dehydrated, mixed and dissolved with N, N-dimethylformamide, and reacted with diisocyanate after cooling to generate a prepolymer; the prepolymer and the chain extender undergo nucleophilic addition reaction to extend the chain, and the prepolymer continues to undergo nucleophilic addition reaction with natural amino acid monomers to prepare a polyurethane elastomer; divalent metal ions are loaded onto the elastomer, and after freeze-drying, a polyurethane sponge is prepared. The polyurethane sponge prepared by the present invention has excellent degradability, biocompatibility and antibacterial properties, and can be applied to the biomedical field.

A novel amino acid-based cationic lipid contains unsaturated bonds, represented by the general formula (1). The amino acids or derivatives used as starting materials in the preparation process are simple and easily obtainable, offering simplicity, safety, and cost-effectiveness. The amino acid-based cationic lipid of this invention features unsaturated hydrocarbon tails and a tertiary amine moiety derived from an amino acid residue. The lipid nanoparticles (LNPs) prepared from this lipid exhibit enhanced membrane fluidity, which improves membrane fusion and facilitates cellular uptake. As a result, the delivery efficiency of the amino acid-based cationic lipid containing unsaturated bonds as a delivery material is significantly improved.

Antimicrobial compositions comprising at least an amine based antimicrobial agent and an alkanolamine are disclosed. The disclosed compositions may be free of quaternary ammonium compounds. The disclosed compositions have antimicrobial properties and fast efficacy against yeasts and bacteria.

The present invention relates to the technical field of degradable materials, and in particular to a method for preparing an amino acid-based degradable material, comprising the following steps: S1.1, converting calcium glutamate into an amidate under catalysis; S1.2, mixing the amidate with threonine phosphate to obtain a sediment; S1.3, further modifying the sediment with citric acid to obtain a degradable substrate; S1.4, thoroughly and uniformly mixing the degradable substrate, a bioactive molecule, a plasticizer, a stabilizer, and an antioxidant, and then extruding the mixture with a twin-screw extruder to obtain an amino acid-based degradable material; wherein the degradable substrate is prepared from calcium glutamate, threonine phosphate, and citric acid in a mass ratio of 7:3-4:0.5-1; calcium glutamate is used to construct a basic skeleton of the material, and threonine phosphate further enhances structural stability and improves mechanical strength, thereby balancing mechanical properties and degradation cycle, and having broad application prospects.

The invention relates to the technical field of medical / health-care patches, and discloses a detoxification plaster and a preparation method thereof, the detoxification plaster is composed of a backing layer, a plaster layer and an anti-sticking layer, and the plaster layer comprises Chinese herbal medicinal ingredients such as wormwood and poria cocos and auxiliary materials such as amino acid-based polymer and nano-silver particles. Traditional Chinese medicine effective components are extracted through water decoction and mixed with a hot-melt pressure-sensitive adhesive and the like for paste spreading. The plaster solves the problems that an existing product is unstable in component, poor in adhesion, single in effect and the like, has the effects of detoxifying, resisting bacteria and relieving, and is good in viscosity, convenient to use and suitable for batch production.

The invention provides an amino acid-based adhesive as well as a preparation method and application thereof, and the preparation method comprises the following steps: A) mixing small organic molecule super alkali with aldehyde, heating and stirring to obtain a eutectic solvent; the organic micromolecule super alkali comprises 1, 8-diazabicyclo [5.4. 0] undec-7-alkene and / or 1, 5-diazabicyclo [4.3. 0] nonyl-5-alkene, and the organic micromolecule super alkali comprises 1, 8-diazabicyclo [5.4. 0] undec-7-alkene and / or 1, 5 The aldehyde comprises one or more of vanillin, cinnamyl aldehyde and furfural; and B) mixing the eutectic solvent with amino acid, and heating for reaction to obtain the amino acid-based adhesive. Compared with traditional urea-formaldehyde resin, the amino acid-based adhesive prepared by the method is higher in bonding strength, a reliable way is provided for preparing green and safe plywood, a one-pot method is used for preparation, and the preparation process is simpler.

The invention relates to a specific small molecule compound of a GLYR1 target spot and application thereof, and belongs to the field of biological medicine. The invention provides a small molecule compound C20H32O5, which is specifically combined with 27185-285amino acid motifs of glyoxylate reductase homologue-1 (GLYR1) protein, so that the combining capacity of the GLYR1 and chromosome DNA in a cell nucleus is reduced, and gene transcription is inhibited; meanwhile, the retention of GLYR1 in cytoplasm is prolonged, and the phosphorylation levels of ERK and MAPK are reduced, so that the transcription up-regulation of proinflammatory cytokines in macrophages is inhibited. The compound rapidly inhibits inflammatory storm caused by coronavirus infection, and significantly reduces severe illness and death risks; experiments prove that the survival rate in an SARS-CoV-2 infected mouse model is increased to 100% from 63.5%, the survival rate in an MHV-3 infected model is remarkably increased, and tissue pathological injuries of lungs and spleens are relieved.

The present invention addresses the problem of providing a method for reducing cracks and sweating in a transparent solid composition containing an amino acid-based gelling agent. Provided are: a transparent solid cosmetic comprising an amino acid-based gelling agent and a fatty acid ester having a C3 or higher hydrocarbon side chain; a premix for preparing the cosmetic; and a method for reducing cracking and sweating, the method comprising blending a fatty acid ester having a C3 or higher hydrocarbon side chain into the transparent solid cosmetic containing an amino acid-based gelling agent.

The utility model discloses an amino acid base stock storage tank with a cooling mechanism, which comprises a tank body, one side of the tank body is provided with a water tank, the bottom of the water tank is fixedly connected with a water pump, the water pump is communicated with the water tank through a communicating pipe, one side of the water pump is communicated with a conveying pipe, and the cooling mechanism is started by starting the water pump. Water in the water tank is conveyed into the conveying pipe through the communicating pipe, then the water is conveyed into the annular pipe through the conveying pipe, then the water is sprayed to the surface of the tank body through the spray head to be cooled, and the sprayed water flows into the collecting tank through the tank body and is conveyed into the filtering tank through the water conveying pipe. After being filtered by the first filter screen, the second filter screen and the third filter screen, water flows into the water tank again through the through holes to form circulation, and after being used for a long time, the three filter screens are sequentially disassembled, assembled and cleaned through the fixing mechanisms, so that the circulating water in the cooling process can be filtered, and the cooling effect is improved. Therefore, the spray holes are prevented from being blocked.

The application discloses a luminescent oligopeptide based on natural amino acids and a preparation method and application in a biological system fluorescent probe and a virtual screening method thereof. The amino acid sequence of the luminescent oligopeptide is proline-tyrosine-tryptophan or proline-tryptophan-asparagine. The preparation method adopts a solid-phase synthesis method. The virtual screening method comprises the following steps: constructing a dipeptide structure library by using 22 kinds of natural amino acids, taking the time-dependent density functional theory as a calculation method, comparing and calculating by using two kinds of functionals, namely, omegaB97XD and B3LYP-D3, screening an excellent dipeptide in optical performance, inserting an amino acid element at any position of the dipeptide to construct a tripeptide structure library, performing quantitative calculation, screening a target tripeptide structure with a narrow band gap and strong oscillator strength, and taking the target tripeptide structure as a luminescent oligopeptide candidate based on natural amino acids.