17 results about "Protonation" patented technology

The application discloses a preparation method of a copper-based metal complex and application of the copper-based metal complex in antioxidation activity, relates to the technical field of functional materials, and has the chemical formula [Cu(H3dhbdc)2(H2O)2], wherein H3dhbdc is deprotonated 2,3-dihydroxyterephthalic acid. The copper-based metal complex has specific crystal structure and spatial structure, high synthesis purity, and good stability, and can be used in antioxidation activity. Under the same condition, the scavenging ability of H4dhbdc and the copper-based metal complex on •OH and O2 •‑ is explored, the copper-based metal complex is equivalent to H4dhbdc in terms of the scavenging effect on •OH free radicals, and is better than H4dhbdc in terms of the scavenging effect on O2 •‑ free radicals, and it is shown that the complex Cu 2+ after complexation not only retains the antioxidation activity of H4dhbdc, but also enhances the enzyme activity of H4dhbdc.

This application discloses a crystal, a rare-earth-doped crystal, its preparation method, and its applications, belonging to the field of crystal materials. The chemical formula of the crystal is [Gd(L)]. 1.5 (DMA)] n Formula I; in Formula I, L is a ligand formed by deprotonated benzene polycarboxylic acid; benzene polycarboxylic acid is selected from any one of terephthalic acid, phthalic acid, and isophthalic acid; DMA is N , N -Dimethylacetamide; n ∞ represents continuous repetition and infinite extension. The crystal is rare-earth doped, and the chemical formula of the rare-earth doped crystal is [Gd]. 1‑x% (L) 1.5 (DMA)] n :x% Ln 3+ Equation II; in Equation II, x = 0.1~10; Ln 3+ Selected from Tb 3+ Or Eu 3+ Any one of the following. It has potential application value in fields such as fluorescent materials, multicolor display materials, long afterglow materials, X-ray detection and imaging materials, radiation detection dosimeters, and optical information encryption. The preparation method used in this application can be easily achieved through solution reaction under relatively mild conditions, with low cost and strong industrial feasibility.

The application discloses a method for synthesizing an alpha-position chiral nitrogen heteroaromatic ring under the synergistic catalysis of a chiral phosphoric acid and a Lewis acid, and the method comprises the following steps: taking a nitrogen heteroaromatic ring olefin I as an electrophilic reagent, taking an aryl alkyl boronic acid II as a carbon nucleophile, and under the synergistic catalysis of a Lewis acid catalyst and a chiral phosphoric acid catalyst, in the presence of an organic solvent, an additive and a proton source, performing a conjugate addition-asymmetric protonation reaction to generate an alpha-position chiral nitrogen heteroaromatic compound shown in formula V, and the reaction is shown as follows: The application provides a conjugate addition-asymmetric protonation strategy for a nitrogen heteroaromatic ring olefin, which is synergistically catalyzed by a chiral phosphoric acid and a Lewis acid (Fe(OTs)3) and involves an organic boron reagent, a series of alpha-position chiral nitrogen heteroaromatic compounds are successfully synthesized by using the catalytic system, the highest enantioselectivity reaches 98% ee, and good universality is shown for aryl, heterocyclic and polysubstituted substrates, and the bottleneck problem of low reactivity of 1,1-disubstituted substrates in a traditional method is effectively overcome.

This invention discloses a method for preparing a protonated Hβ molecular sieve catalyst using acid treatment modification, the obtained catalyst, and its application. A β molecular sieve is mixed with an ammonium chloride solution, and after sufficient ion exchange, the resulting mixture is transferred to a centrifuge tube, centrifuged, and washed several times with water. The lower solid layer is dried and ground. After grinding, the solid is placed in a crucible, which is then placed in a muffle furnace for a first calcination at high temperature, yielding an H-type β molecular sieve. The obtained H-type β molecular sieve is mixed with an inorganic acid solution, and after sufficient acid leaching, the resulting mixture is allowed to cool to room temperature, filtered, and washed several times with water. The upper solid layer is dried and ground. After grinding, the solid is placed in a crucible, which is then placed in a muffle furnace for a second calcination at high temperature, yielding a protonated Hβ molecular sieve catalyst. This invention first hydrogenates the molecular sieve and then modifies it with an acid solution to construct highly efficient and stable active sites, thereby achieving efficient NO removal.

The application discloses a preparation method of a copper-based metal-organic framework material and application of the copper-based metal-organic framework material in antioxidant activity, relates to the field of metal-organic framework material synthesis, and the chemical formula of the copper-based metal-organic framework material is [Cu II 6(o-dhbdc)2(o-H2dhbdc) 0.5 (o-H2dhbdc) 0.5 (o-H3dhbdc)2.(H2O)3], which is abbreviated as Cu-PCP, wherein dhbdc, H2dhbdc and H3dhbdc are deprotonated 2,3-dihydroxyterephthalic acid. The Cu-PCP has a clear crystal structure and spatial configuration, high synthesis purity, excellent stability, and exhibits significant antioxidant activity; the material has significantly enhanced O₂ •⁻ elimination capacity; in addition, Cu²⁺ not only retains the original antioxidant performance of the ligand, but also further improves the overall free radical elimination capacity of the material.

This invention discloses a method for preparing nano-high-entropy metal-organic frameworks (MOFs) and their applications. The preparation method includes the following steps: 1) dissolving five or more metal salt precursors in water to obtain solution A; 2) mixing and dissolving an organic ligand with a deprotonated basic additive in water to form solution B; 3) starting a high-gravity reactor; 4) introducing solutions A and B into the high-gravity reactor at room temperature and atmospheric pressure using a peristaltic pump, collecting the resulting suspension, and allowing the suspension to stand for aging to obtain the corresponding high-entropy MOF suspension; 5) centrifuging, washing, and drying the above suspension to obtain the high-entropy MOF material. This preparation method is carried out at room temperature and atmospheric pressure, using only water as the reaction solvent; the method is simple, the reaction is rapid, improving production efficiency, and it does not use organic solvents, making it environmentally friendly; the obtained nano-high-entropy MOFs product has a controllable particle size, with an average particle width ≤250 nm and a specific surface area of ​​up to 860 m². 2 / g.

This invention discloses an N-substituted pyridine fluoroborate inner salt reagent, its preparation method, and its application in the preparation of F-18 radiopharmaceuticals. The N-substituted pyridine fluoroborate inner salt reagent is obtained by reacting protonated pyridine fluoroborate of Formula I with a compound of Formula II in the presence of a solvent. This inner salt reagent, through a substituted alkyl group linked to the pyridine N-phase, can undergo a coupling reaction with molecules containing specific groups (including drug molecules or their derivatives) to generate F-18 radiopharmaceutical precursors. Further isotope exchange reactions yield the F-18 radiopharmaceutical. By adjusting the types of substituents in the substituted alkyl group, this invention can achieve the construction of structurally diverse F-18 radiopharmaceutical precursors with different drug molecules or their derivatives. Furthermore, the prepared F-18 radiopharmaceutical precursors exhibit good stability in aqueous phase and can undergo efficient reactions in aqueous buffer solutions. 18 F- 19 The F isotope exchange reaction avoids the time-consuming dehydration process in the traditional F-18 radiopharmaceutical synthesis, greatly shortening the synthesis time and thus effectively improving the efficiency of F-18 radiopharmaceutical synthesis. 18 F-labeling rate.

This paper describes a class of dyes containing 1,4-diazabicyclo[2.2.2]octane, their preparation methods, and applications, belonging to the fields of optical diagnostics and biomedicine. The dye comprises the dye molecule and 1,4-diazabicyclo[2.2.2]octane covalently coupled to the dye. 1,4-diazabicyclo[2.2.2]octane directly quenches singlet oxygen generated by the dye, affecting the triplet state of the dye, thereby improving its anti-bleaching ability and photostability, and reducing phototoxicity during fluorescence imaging. Furthermore, the introduction of 1,4-diazabicyclo[2.2.2]octane significantly improves the brightness of the dye, inhibits photoscintillation, and enhances its water solubility. Its protonation characteristic enhances the dye's mitochondrial targeting ability. These compounds, by reducing singlet oxygen and enhancing the local photothermal and reactive oxygen species production in mitochondria, induce potent cell necrosis, apoptosis, and immunogenic cell death, comprehensively improving anticancer efficacy. These compounds exhibit excellent photostability and low skin toxicity, showing broad application prospects.

This invention discloses an ultrastable hydrogen-bonded organic framework material, its preparation method, and its applications. The preparation method involves mixing a deprotonated solution of 6,6',6'',6'''-(pyrene-1,3,6,8-tetramethyl)tetra(2-naphthoic acid) with a solution of 4,4',4'',4'''-methanetetraphenylamidine tetrahydrochloride. After standing in the dark, the mixture is centrifuged, washed, and lyophilized. The resulting hydrogen-bonded organic framework material exhibits excellent stability and high photocatalytic efficiency, making it effective for the photocatalytic preparation of BHMF from HMF. Adding MsAcT enzyme powder to the 4,4',4'',4'''-methanetetraphenylamidine tetrahydrochloride solution yields a hydrogen-bonded organic framework material encapsulating MsAcT enzyme. This material can be effectively used for the one-pot photocatalytic preparation of BHMF diacetate from HMF.

The present application relates to the field of fluorescent sensing technology, and particularly relates to a Eu(III) metal organic framework crystalline material, a preparation method and application thereof. The Eu(III) metal organic framework crystalline material is formed by assembling a multi-nuclear Eu ion cluster and a polycarboxyl organic ligand, and an asymmetric structural unit thereof comprises a plurality of valence states of Eu ions, monodentate coordination water molecules and partially deprotonated H(DDODA) 3‑ ligands. The Eu(III) is in an octahedral coordination configuration, and the Eu(II) is in a nonahedral coordination configuration, and a trinuclear {Eu3(H2O)5(COO) 18} secondary structural unit is formed by chelation and bridging action of carboxyl oxygen atoms. The secondary structural unit is further connected to form a one-dimensional chain structure through bridging carboxyl of the ligand, and the one-dimensional chains are further connected through carboxyl not participating in bridging and pyridine / pyridine groups, and finally a stable three-dimensional metal organic framework structure is constructed. The Eu(III) metal organic framework crystalline material has good fluorescence properties and stability, and can be applied to the field of fluorescent sensing.

This invention discloses a method for preparing and applying a two-dimensional lead bromide perovskite single crystal based on 1-amino-4-methylpiperazine in the Dion-Jacobson phase, wherein the chemical formula of the single crystal is (C5H). 14 N3)PbBr4, where C5H 14 N3 2+ It is a diprotonated 1-amino-4-methylpiperazine cation; single-crystal X-ray diffraction analysis shows that it has a typical two-dimensional Dion-Jacobson phase layered structure, belongs to the monoclinic crystal system, space group P21 / n, and its structure is dominated by [PbBr4]. 2‑ The single crystal is constructed by alternating stacks of octahedral inorganic layers and diammonium cation organic layers. The preparation method involves: first, dissolving 1-amino-4-methylpiperazine in hypophosphite and lead oxide in hydrobromic acid; then mixing the two solutions and heating them at 100-130°C to form a homogeneous precursor solution; finally, obtaining the single crystal through a programmed slow cooling method. This invention utilizes hydrobromic acid as a medium to achieve precise protonation of organic amines and a high-concentration bromine environment. The resulting single crystal exhibits high crystal quality and good stability, demonstrating significant application potential in optoelectronic fields such as polarization detection, nonlinear optics, and light-emitting devices.

This invention relates to a method for preparing AEI-based IZM-10 zeolite, the method comprising at least mixing the following substances in an aqueous medium: FAU-based zeolite, whose SiO2... 2(FAU) / Al2O 3(FAU) The precursor gel obtained at the end of step i) is then subjected to hydrothermal treatment, comprising a molar ratio of 10 to 60 (inclusive of endpoints) and less than 0.005% by mass of sodium in cationic form, a nitrogen-containing organic compound R, wherein R is (6R,10S)-6,10-dimethyl-5-aza-onium spiro[4.5]decane in hydroxide form, and optionally sodium hydroxide. The invention also relates to AEI-based zeolites having a SiO2 / Al2O3 molar ratio of 10 to 60 (inclusive of endpoints) and a purity greater than or equal to 98% by weight, preferably greater than or equal to 99% by weight, wherein the zeolite is in a partially or fully protonated form and is obtained by the method described.

The application belongs to the technical field of proton exchange membranes, and discloses a high-chemical-stability non-charged proton exchange membrane for acid recovery by diffusion dialysis, a preparation method and application thereof. A strong electron-attracting C-F bond, a sulfonyl unit [-SO2-] and a nitrogen-containing heterocycle capable of being protonated are introduced into a polybenzimidazole main chain, and two copolymerization modes are adopted, namely, copolymerization of a carboxylic acid monomer containing a strong electron-attracting group and a tetramine monomer containing a heterocyclic nitrogen, and copolymerization of a carboxylic acid monomer containing a heterocyclic nitrogen and a tetramine monomer containing a strong electron-attracting group; or a multi-monomer copolymerization strategy such as a two-monomer copolymerization strategy and a three-monomer copolymerization strategy can be simultaneously adopted, and then a solution is coated by a film coater to form a film. The non-charged proton exchange membrane prepared by the method has excellent acid recovery performance and chemical stability.

The application discloses a preparation method of 4-chloro-1-naphthol and belongs to the technical field of organic synthesis. 1-naphthol is used as a raw material to react with a deprotonation reagent, then reacts with a borate ester, and after acidification, 1-hydroxynaphthalene-2-boronic acid is generated; then, the 1-hydroxynaphthalene-2-boronic acid reacts with a chlorination reagent to obtain 4-chloro-1-hydroxynaphthalene-2-boronic acid; finally, the 4-chloro-1-hydroxynaphthalene-2-boronic acid reacts with an organic base under the action of copper sulfate to remove the boronic acid and generate 4-chloro-1-naphthol. In the application, 1-naphthol is used as a starting raw material, a boronic acid group is first introduced at the 2-position, so that chlorination reaction is positioned at the 4-position in the later stage, generation of ortho-position, polychlorinated by-products is effectively inhibited, the route is short, the operability is good, and the overall yield is high.

This invention relates to a europium-based metal-organic framework material constructed based on 4-((3-(pyrazin-2-yl)-1H-pyrazol-1-yl)methyl)benzoic acid ligand, its preparation method, and its applications. The invention pertains to the fields of metal-organic framework materials, luminescent functional materials, and fluorescence sensing technologies. The chemical formula of the europium-based metal-organic framework material prepared by this invention is: [Eu(ppmb)2(NO3)(H2O)2] n ; where ppmb is the ligand after deprotonation of Hppmb; the structure of Hppmb is; the europium-based metal-organic framework material belongs to the triclinic crystal system, space group P-1, and unit cell parameters are a=9.727(4) Å, b=14.197(5) Å, c=25.615(9) Å, α=77.899(1)°, β=86.231(1)°, γ=70.044(1)°, and it is used in the detection of furazolidone.