84 results about "Protonation" patented technology

The invention discloses a dual-response dual-network fracturing fluid thickening agent and a preparation method thereof, and relates to the technical field of oilfield chemistry and fine chemistry, a nonionic monomer and a cross-linking agent are subjected to cross-linking polymerization under the action of an initiator to form a first network structure, and a carboxyl-containing polymer filled in the first network structure is utilized to form a second network structure. Wherein the nonionic monomer is at least one of acrylamide and modified acrylamide. According to the dual-network fracturing fluid thickening agent, carboxyl and high-valence cations are subjected to ionic crosslinking under high salinity to form an egg box structure, so that molecular chain aggregation and gelation are caused. Under the acidic condition, the charge density of carboxyl protonated molecular chains is reduced, the electrostatic repulsive force is weakened, and inter-chain aggregation and precipitation are caused. In addition, protonated carboxyl and hydroxyl form intramolecular and intermolecular hydrogen bonds, so that interchain aggregation is further promoted. Therefore, the prepared dual-network thickening agent has the characteristics of high density, salt resistance and acid resistance, and the yield increase and transformation effect of an unconventional oil and gas reservoir is remarkably improved.

The invention discloses a universal method for proton adsorption induced ultrahigh surface metal monatomic loading, which comprises the following steps: (S1) uniformly dispersing a carrier subjected to protonation treatment by a strong acid solution or an organic solvent in a metal salt aqueous solution to obtain an acid mixed solution; (S2) carrying out drying treatment on the acidic mixed solution containing the carrier and metal salt ions, then grinding into powder, and carrying out secondary drying; and (S3) putting the powder obtained by grinding into a tubular furnace, and calcining in two steps under inert gas so as to form monatomic active sites on the surface of the catalytic material, thereby obtaining the ultrahigh surface metal monatomic loaded catalytic material. The method disclosed by the invention is simple to operate, wide in application range, uniform in sample dispersion and extremely high in monatomic surface density, the loading capacity can reach more than 30wt%, and abundant reaction active sites are provided for catalytic reaction. The monatomic catalytic material prepared by the method has excellent catalytic performance.

The invention provides a method for quantitatively detecting a nitrosamine impurity in a macassavir raw material medicine and an intermediate TG9, and relates to the technical field of medicine detection, the method comprises the step of detecting the nitrosamine impurity in the macassavir raw material medicine or the intermediate TG9 sample by adopting a high performance liquid chromatography and mass spectrometry combined method, the mobile phase A is a formic acid solution, and the mobile phase B is a formic acid methanol solution; gradients, such as segmented gradients of the raw material medicines, are respectively designed for the intermediate and the raw material medicines through a dynamic gradient elution program, so that TG801, TG901 and TG1001 realize baseline separation; an acidic mobile phase is adopted, formic acid acetonitrile is added into the solution, protonation competition of nitrosamine impurities is inhibited, the ionization efficiency and stability are improved, the sensitivity is high, and the LOQ of the method is 0.033 ng / g. The technical problem that in the prior art, a method for quantitatively detecting three nitrosamine impurities in a macassavir raw material medicine and an intermediate TG9 does not exist is solved.

The application discloses application of 2-amino isophthalic acid (2-AIA) as a MALDI matrix in characterization of oligosaccharide additives in food. The skeleton structure of 2-AIA has a strong ultraviolet absorption group and a protonation site, which is beneficial to laser energy transmission and desorption ionization process of the measured object. Meanwhile, 2-AIA has multiple polar functional groups, which can effectively enhance the directional combination of the hydroxyl group of 2-AIA and oligosaccharide, and improve the anti-interference ability of impurities in a complex system. In addition, 2-AIA and a traditional organic matrix alpha-cyano-4-hydroxycinnamic acid (CHCA) are combined as a binary matrix (CHCA / 2-AIA), which can play a synergistic role of the double matrix, significantly improve the detection sensitivity of oligosaccharide. On the other hand, the combination of CHCA and 2-AIA with different pH values can significantly improve the uniformity of the co-crystallization, and improve the accuracy and reproducibility of quantitative detection.

The invention discloses cysteine mediated Hf / Cu bimetal synergistic self-assembled nano-particles as well as a preparation method and application of the cysteine mediated Hf / Cu bimetal synergistic self-assembled nano-particles. According to the method, cysteine is used as a multifunctional ligand, carboxyl and sulfydryl of cysteine are in bridge connection with metal through coordination, ligand chelation and assembly guiding effects are synchronously exerted, bimetallic ions are induced to be cooperatively self-assembled in an alkaline system (pH is 9-10), and metal cysteine self-assembled nanoparticles with uniform structures are formed through in-situ nucleation and multistage aggregation. According to the method, the ligand function and the bimetallic synergistic effect are accurately matched, the synthesis process is mild (room temperature), the operation is simple and convenient, and the product is excellent in dispersity and stability. Meanwhile, a close coordination structure constructed by cysteine provides a key channel for energy / electron transfer from sensitizing metal to Cu under X-ray irradiation, and lays a structural foundation for subsequent catalytic effect enhancement.

The invention provides a production system and a production method of 3-methoxy-N, N-bis (2-ethoxyl) aniline. According to the production method, functionalized ionic liquid ([HEMIM] HSO4, [HEMIM] H2PO4, [APMIM] HSO4 and [APMIM] H2PO4) and triethylamine are adopted to construct an efficient synergistic catalysis system. Amino (-NH2) or hydroxyl (-OH) of a cation side chain of the ionic liquid is combined with nitrogen atoms of triethylamine through hydrogen bonds, meanwhile, acidic anions (HSO4 <-> / H2PO4 <->) of the ionic liquid and protonated triethylamine ([H-TEA] < + >) generated in the reaction can form strong ion pairs, and the overall stability of a catalytic system is remarkably enhanced through the multiple non-covalent interaction. Compared with traditional acid catalysis or single ionic liquid catalysis, the synergistic catalysis system is high in catalytic activity, excellent in selectivity and high in stability, and the yield and purity of the target product 3-methoxy-N, N-bis (2-ethoxyl) aniline can be remarkably improved.

The application discloses an aggregation-induced emission metal organic framework, a preparation method thereof and fluorescent / colorimetric dual-mode intelligent detection for trace HCl. 2+ The aggregation-induced emission metal organic framework is prepared by providing Zn(NO3)3.6H2O as Zn 2+ , imidazole-2-formaldehyde and an AIE molecule HDBB as organic ligands, and through a solvothermal method to obtain ZIF-90-HDBB, which can change the aggregation state fluorescence from yellow green to orange red after being contacted with HCl gas; the ZIF-90-HDBB is uniformly loaded on cellulose filter paper to obtain a paper-based sensor for portable detection of HCl, and through combination with a color recognition APP of a smart phone, the HCl can be rapidly and sensitively detected on site in a fluorescent / colorimetric dual mode. Since the HDBB molecule is prone to protonation under acidic conditions, the fluorescence color changes, and therefore the material can be accurately and efficiently used for detection of acidic gas, and the material can be recycled.

The invention discloses a method for catalyzing hydrolysis of hexafluorophosphate radicals by using a bifunctional solid acid material, the main active sites of the bifunctional solid acid material in the method are a Brnsted acid site formed by combining protonated sulfate radicals (HSO4 <->) with hydroxyl groups on the surface of TiO2 and a Ti < 4 + > (Lewis acid) site enhanced by induction of the Brnsted acid site, and in the catalytic hydrolysis process, the Brnsted acid site and the Ti4 < + > (Lewis acid) site can be used for catalyzing hydrolysis of the hexafluorophosphate radicals by using the bifunctional solid acid material. Ti4 < + > (Lewis acid site) generates strong adsorption and activation effects on PF6 <->, adjacent HSO4 <-> (Brnsted acid site) and PF6 <-> generate H.. F-P interaction, and the two sites apply a synergistic stretching effect on a P-F bond from different directions, so that a stable regular octahedron structure of PF6 <-> is greatly damaged, a reaction energy barrier of P-F bond breakage is remarkably reduced, efficient hydrolysis of PF6 <-> is realized, and the reaction time is shortened. The method has the advantages that the hydrolysis efficiency is high, the hydrothermal stability is good, extreme acid and alkali environments are not needed, the bifunctional catalyst is easy to regenerate and the like, and a brand new technical path and a solution are provided for harmless treatment of the hexafluorophosphoric acid-containing wastewater.

The application discloses a preparation method of a copper-based metal complex and application of the copper-based metal complex in antioxidation activity, relates to the technical field of functional materials, and has the chemical formula [Cu(H3dhbdc)2(H2O)2], wherein H3dhbdc is deprotonated 2,3-dihydroxyterephthalic acid. The copper-based metal complex has specific crystal structure and spatial structure, high synthesis purity, and good stability, and can be used in antioxidation activity. Under the same condition, the scavenging ability of H4dhbdc and the copper-based metal complex on •OH and O2 •‑ is explored, the copper-based metal complex is equivalent to H4dhbdc in terms of the scavenging effect on •OH free radicals, and is better than H4dhbdc in terms of the scavenging effect on O2 •‑ free radicals, and it is shown that the complex Cu 2+ after complexation not only retains the antioxidation activity of H4dhbdc, but also enhances the enzyme activity of H4dhbdc.

The application discloses a dual-response double-network fracturing fluid thickening agent and a preparation method thereof, relates to the technical field of oil field chemistry and fine chemistry, and comprises the following steps: cross-linking and polymerizing non-ionic monomers and a cross-linking agent under the action of an initiator to form a first network structure, and utilizing a carboxyl-containing polymer filled in the first network structure to form a second network structure. The non-ionic monomers are at least one of acrylamide and modified acrylamide. The double-network fracturing fluid thickening agent is ionically cross-linked with high-valence cations under high salinity, forms an "egg box" structure, causes molecular chain aggregation and gelation. Under acidic conditions, the carboxyl groups are protonated, the charge density of the molecular chains is reduced, the electrostatic repulsion is weakened, inter-chain aggregation and precipitation are caused. In addition, the protonated carboxyl groups form intramolecular and intermolecular hydrogen bonds with hydroxyl groups, further promote inter-chain aggregation. Therefore, the prepared double-network thickening agent has the characteristics of high density, salt resistance and acid resistance, and remarkably improves the stimulation effect of unconventional oil and gas reservoirs.

This application discloses a crystal, a rare-earth-doped crystal, its preparation method, and its applications, belonging to the field of crystal materials. The chemical formula of the crystal is [Gd(L)]. 1.5 (DMA)] n Formula I; in Formula I, L is a ligand formed by deprotonated benzene polycarboxylic acid; benzene polycarboxylic acid is selected from any one of terephthalic acid, phthalic acid, and isophthalic acid; DMA is N , N -Dimethylacetamide; n ∞ represents continuous repetition and infinite extension. The crystal is rare-earth doped, and the chemical formula of the rare-earth doped crystal is [Gd]. 1‑x% (L) 1.5 (DMA)] n :x% Ln 3+ Equation II; in Equation II, x = 0.1~10; Ln 3+ Selected from Tb 3+ Or Eu 3+ Any one of the following. It has potential application value in fields such as fluorescent materials, multicolor display materials, long afterglow materials, X-ray detection and imaging materials, radiation detection dosimeters, and optical information encryption. The preparation method used in this application can be easily achieved through solution reaction under relatively mild conditions, with low cost and strong industrial feasibility.

The application belongs to the technical field of asymmetric catalytic synthesis, and particularly relates to an alpha-carbon chiral phosphine compound and a preparation method thereof. In a protective gas atmosphere, an asymmetric boron protonation reaction is carried out on a dienyl phosphine oxide compound shown in a structure of formula II, pinacol borate, a copper (I) catalyst, a chiral ligand, an organic alkaline compound and a proton additive in a polar organic solvent to obtain an alpha-carbon chiral phosphine compound shown in a structure of formula I; the chiral ligand is a cyclic phosphine ligand (S, S)-Ph-BPE or a cyclic phosphine ligand (R, R)-Ph-BPE. The preparation method provided by the application can synthesize the alpha-carbon chiral phosphine compound shown in the structure of formula I with high yield and excellent enantioselectivity, the synthesis method is simple and low in cost, and the alpha-carbon chiral phosphine compound can be further converted into a new optically active product.

The application discloses a method for synthesizing an alpha-position chiral nitrogen heteroaromatic ring under the synergistic catalysis of a chiral phosphoric acid and a Lewis acid, and the method comprises the following steps: taking a nitrogen heteroaromatic ring olefin I as an electrophilic reagent, taking an aryl alkyl boronic acid II as a carbon nucleophile, and under the synergistic catalysis of a Lewis acid catalyst and a chiral phosphoric acid catalyst, in the presence of an organic solvent, an additive and a proton source, performing a conjugate addition-asymmetric protonation reaction to generate an alpha-position chiral nitrogen heteroaromatic compound shown in formula V, and the reaction is shown as follows: The application provides a conjugate addition-asymmetric protonation strategy for a nitrogen heteroaromatic ring olefin, which is synergistically catalyzed by a chiral phosphoric acid and a Lewis acid (Fe(OTs)3) and involves an organic boron reagent, a series of alpha-position chiral nitrogen heteroaromatic compounds are successfully synthesized by using the catalytic system, the highest enantioselectivity reaches 98% ee, and good universality is shown for aryl, heterocyclic and polysubstituted substrates, and the bottleneck problem of low reactivity of 1,1-disubstituted substrates in a traditional method is effectively overcome.

The invention provides a rare earth metal-organic framework material as well as a preparation method and application thereof, and relates to the technical field of fluorescence detection, the general formula of the material is {[Ln4 (THBA) 2 (H2O) 5]. 4H2O} n, Ln is Eu < 3 + > or Tb < 3 + > ions; tHBA is a deprotonated [1, 1 ', 4', 1 ''-terphenyl]-2 ', 3, 3', 5, 5 ', 5''-hexacarboxylic acid ligand; the material belongs to a triclinic system, the space group is P1, the material has a three-dimensional porous frame structure, and each Ln < 3 + > ion is in an eight-coordinate configuration; n > = 1, and n is an integer. The material not only shows high-sensitivity, high-selectivity and quick-response detectability to the harmful substance malachite green, but also successfully realizes conversion from a powder material to a portable device, and has wide application prospects in the fields of environmental monitoring, food safety, information encryption and the like.

The invention discloses a protonated Cu-HHTP hydrogen sulfide gas-sensitive material as well as a preparation method and application thereof, and belongs to the technical field of gas sensors and metal organic framework materials, the gas-sensitive material is based on Cu3 (HHTP) 2 (Cu-HHTP), and an exposed copper metal cluster can be used as an adsorption / desorption site of H2S gas molecules, so that the gas-sensitive material can be applied to the field of gas sensors and metal organic framework materials. Therefore, the material has response capability to H2S in an intrinsic state. By carrying out protonation treatment on the material, introduced H < + > provides a richer electron transmission channel while effectively reducing the intrinsic resistance of the material, so that the conduction efficiency of H2S in a material system is remarkably enhanced. In addition, due to the inherent lamellar morphology and porous rod-like structure of Cu3 (HHTP) 2, the material is endowed with the characteristic of high specific surface area. The structural advantage is combined with the protonation design to jointly improve the gas-sensitive property of the material.

The application belongs to the technical field of multifunctional photoelectric materials, and particularly relates to an organic-inorganic hybrid copper-based halide crystal material, a preparation method and application. R -2MePICu2X4, S -2MePICu2X4, R -2MePI)4Cu4X 12 or S -2MePI)4Cu4X 12 ; 2MePI is a 2-methylpiperazine cation, and X is a halogen. The application forms a coordination bond between monovalent metal Cu and a halogen, forms different inorganic cluster structures CuX, forms [Cu2X6] 4‑ or [Cu2X4] 2‑ units, and the 2-methylpiperazine cation is positively charged after protonation, and the formed CuX can achieve charge balance, so that the organic-inorganic hybrid copper-based halide crystal material is obtained through ionic bond interaction.

The application discloses a method for determining the content of NBPT in urea, comprising the following steps: S1, preparation of a detection reagent; S2, sample pretreatment; S3, chromatography-mass spectrometry combined detection; and S4, quantitative analysis. The method directly injects a 0.1% formic acid aqueous solution-acetonitrile mobile phase system into an LC-MS / MS system, wherein the formic acid serves as an ionization promoter to significantly improve the protonation efficiency of NBPT under ESI + source, the response intensity of [M+H] + is greater than 10 5 cps, and the derivatization step necessary for a traditional HPLC-UV method is completely eliminated; secondly, a blank matrix extraction liquid is introduced to match a standard curve, and a standard sample is diluted by a urea / fertilizer matrix extraction liquid homologous to the sample to be measured, so that the ion suppression effect of humic acid on the target object is accurately offset, the standard addition recovery rate of a complex matrix sample is stably kept at 85%-99.5%, and the quantitative deviation is less than 5%.

This invention discloses a method for preparing a protonated Hβ molecular sieve catalyst using acid treatment modification, the obtained catalyst, and its application. A β molecular sieve is mixed with an ammonium chloride solution, and after sufficient ion exchange, the resulting mixture is transferred to a centrifuge tube, centrifuged, and washed several times with water. The lower solid layer is dried and ground. After grinding, the solid is placed in a crucible, which is then placed in a muffle furnace for a first calcination at high temperature, yielding an H-type β molecular sieve. The obtained H-type β molecular sieve is mixed with an inorganic acid solution, and after sufficient acid leaching, the resulting mixture is allowed to cool to room temperature, filtered, and washed several times with water. The upper solid layer is dried and ground. After grinding, the solid is placed in a crucible, which is then placed in a muffle furnace for a second calcination at high temperature, yielding a protonated Hβ molecular sieve catalyst. This invention first hydrogenates the molecular sieve and then modifies it with an acid solution to construct highly efficient and stable active sites, thereby achieving efficient NO removal.

The invention is suitable for the technical field of water pollution control, and provides an L.Ln / KCa2Nb3O10 two-dimensional heterojunction and a preparation method thereof.The preparation method comprises the steps that a block material is synthesized through a high-temperature solid-phase reaction, a single-layer or few-layer KCa2Nb3O10 nanosheet is obtained after protonation treatment and layered structure stripping, and conversion from a three-dimensional block to a two-dimensional nanosheet is achieved; and then successfully synthesizing the lamellar coordination polymer from the L.Ln nanosheets through the coordination effect of a linear bis terpyridyl ligand and lanthanide ions. And finally, covering the surface of the heterojunction with a molecular imprinting film and carrying out work modification to enhance the selective adsorption capacity of the molecular imprinting film on PFASs in the environment. According to the scheme, a layered coordination polymer is successfully synthesized by utilizing the coordination effect of a linear bis terpyridyl ligand and lanthanide ions, and controllable synthesis of the two-dimensional nanosheet is realized; fluorine-philic groups are introduced in the synthesis process, so that the heterojunction can selectively adsorb PFASs in the environment, and interference of factors such as temperature, humidity, pH value and a surfactant in the environment is effectively avoided.

The application discloses a preparation method of a copper-based metal-organic framework material and application of the copper-based metal-organic framework material in antioxidant activity, relates to the field of metal-organic framework material synthesis, and the chemical formula of the copper-based metal-organic framework material is [Cu II 6(o-dhbdc)2(o-H2dhbdc) 0.5 (o-H2dhbdc) 0.5 (o-H3dhbdc)2.(H2O)3], which is abbreviated as Cu-PCP, wherein dhbdc, H2dhbdc and H3dhbdc are deprotonated 2,3-dihydroxyterephthalic acid. The Cu-PCP has a clear crystal structure and spatial configuration, high synthesis purity, excellent stability, and exhibits significant antioxidant activity; the material has significantly enhanced O₂ •⁻ elimination capacity; in addition, Cu²⁺ not only retains the original antioxidant performance of the ligand, but also further improves the overall free radical elimination capacity of the material.

The invention discloses an interpenetrating type iron-based metal organic framework material and a preparation method and application thereof, the molecular formula of the material is [Fe3O4 (H2O) 3 (L1) (L2) 4 / 3], in the formula, L1 represents deprotonated 4-(4-carboxybenzamido) benzoic acid, L2 represents deprotonated 1, 3, 5-tri (4-carboxyphenyl) benzene, and n represents 1, 3, 5-tri (4-carboxyphenyl) benzene; the material belongs to a hexagonal crystal system and an R-3c space group, and is prepared by taking a trinuclear iron cluster, 4-(4-carboxybenzamido) benzoic acid and 1, 3, 5-tri (4-carboxyphenyl) benzene as raw materials, acetic acid as a template agent and N, N-dimethylformamide and n-amyl alcohol as solvents through solvothermal reaction. The interpenetrating type iron-based metal organic framework material disclosed by the invention has a relatively large specific surface area and a relatively large pore structure, has good adsorption performance on methane and carbon dioxide, and has a wide application prospect in the fields of methane storage and flue gas carbon dioxide capture.

This invention discloses a method for preparing nano-high-entropy metal-organic frameworks (MOFs) and their applications. The preparation method includes the following steps: 1) dissolving five or more metal salt precursors in water to obtain solution A; 2) mixing and dissolving an organic ligand with a deprotonated basic additive in water to form solution B; 3) starting a high-gravity reactor; 4) introducing solutions A and B into the high-gravity reactor at room temperature and atmospheric pressure using a peristaltic pump, collecting the resulting suspension, and allowing the suspension to stand for aging to obtain the corresponding high-entropy MOF suspension; 5) centrifuging, washing, and drying the above suspension to obtain the high-entropy MOF material. This preparation method is carried out at room temperature and atmospheric pressure, using only water as the reaction solvent; the method is simple, the reaction is rapid, improving production efficiency, and it does not use organic solvents, making it environmentally friendly; the obtained nano-high-entropy MOFs product has a controllable particle size, with an average particle width ≤250 nm and a specific surface area of ​​up to 860 m². 2 / g.

Disclosed herein is a A polyalkanolamine including the structure of formula L1[AL]n[BL]m  (L1)whereinXL1, XL2, XL3 are independently selected from a C1 to C6 alkanediyl;ArL is a 5 or 6 membered N-heteroaromatic ring system including from 1 to 4 N atoms, which may be unsubstituted or substituted by C1 to C6 alkyl;n is an integer of from 2 to 350;m is 0 or an integer of from 1 to 600;o is 1 or an integer of from 2 to 25;BL1 is a continuation of the backbone BL by branching;XL11, XL12, XL13 are independently selected from a C1 to C6 alkanediyl;XL21 is a C1 to C6 alkanediyl;and derivatives thereof obtainable by N-protonation, N-quaternization, substitution, or polyalkoxylation.

The invention provides a preparation method of thermally activated delayed fluorescence type ionic liquid and application of the thermally activated delayed fluorescence type ionic liquid in surface defect passivation of perovskite quantum dots, and the material is a novel material synthesized from a quaternized long alkyl chain material and TADF, and can be used for passivating the surface defects of the perovskite quantum dots. Perovskite quantum dots have become one of the most promising photoelectric materials. However, the oleic acid / oleylamine ligand is obviously separated from the surfaces of the PQDs due to reversible protonation and deprotonation processes, which mainly affects the photoelectric properties of the PQDs. The TADF material is a novel ionic TADF material, cesium and bromide ion vacancies can be passivated, so that the surface defect density is reduced, the stability is improved, and meanwhile, the luminescent brightness and the external quantum efficiency of perovskite can be improved. The invention provides an important thought for further optimizing the photoelectric property and application of the perovskite quantum dots.

This invention discloses a bifunctional metal-organic framework material based on pyridine tetracarboxylic acid ligands, its preparation method, and its applications. It belongs to the field of crystalline materials, and its chemical formula is {[Zn2(L)(5-ATZ)]·1.5DMF·H2O}. n L 4‑ The deprotonated organic ligand (2,5-di-(3,5-dicarboxyphenyl))pyridine is prepared by a solvothermal reaction of the organic ligand (2,5-di-(3,5-dicarboxyphenyl))pyridine with aminotetrazole and zinc nitrate hexahydrate in a mixed solution of N,N-dimethylformamide and nitric acid to obtain colorless crystals. It can be used as a material for CO2 / CH4 and C2H2 / CO2 adsorption and separation or for Fe in aqueous solutions. 3+ Cr2O7 2‑ and CrO4 2‑ This high-sensitivity fluorescent detection material exhibits excellent stability and demonstrates superior performance in gas adsorption and separation, as well as heavy metal ion fluorescence detection.

This invention discloses an N-substituted pyridine fluoroborate inner salt reagent, its preparation method, and its application in the preparation of F-18 radiopharmaceuticals. The N-substituted pyridine fluoroborate inner salt reagent is obtained by reacting protonated pyridine fluoroborate of Formula I with a compound of Formula II in the presence of a solvent. This inner salt reagent, through a substituted alkyl group linked to the pyridine N-phase, can undergo a coupling reaction with molecules containing specific groups (including drug molecules or their derivatives) to generate F-18 radiopharmaceutical precursors. Further isotope exchange reactions yield the F-18 radiopharmaceutical. By adjusting the types of substituents in the substituted alkyl group, this invention can achieve the construction of structurally diverse F-18 radiopharmaceutical precursors with different drug molecules or their derivatives. Furthermore, the prepared F-18 radiopharmaceutical precursors exhibit good stability in aqueous phase and can undergo efficient reactions in aqueous buffer solutions. 18 F- 19 The F isotope exchange reaction avoids the time-consuming dehydration process in the traditional F-18 radiopharmaceutical synthesis, greatly shortening the synthesis time and thus effectively improving the efficiency of F-18 radiopharmaceutical synthesis. 18 F-labeling rate.

This paper describes a class of dyes containing 1,4-diazabicyclo[2.2.2]octane, their preparation methods, and applications, belonging to the fields of optical diagnostics and biomedicine. The dye comprises the dye molecule and 1,4-diazabicyclo[2.2.2]octane covalently coupled to the dye. 1,4-diazabicyclo[2.2.2]octane directly quenches singlet oxygen generated by the dye, affecting the triplet state of the dye, thereby improving its anti-bleaching ability and photostability, and reducing phototoxicity during fluorescence imaging. Furthermore, the introduction of 1,4-diazabicyclo[2.2.2]octane significantly improves the brightness of the dye, inhibits photoscintillation, and enhances its water solubility. Its protonation characteristic enhances the dye's mitochondrial targeting ability. These compounds, by reducing singlet oxygen and enhancing the local photothermal and reactive oxygen species production in mitochondria, induce potent cell necrosis, apoptosis, and immunogenic cell death, comprehensively improving anticancer efficacy. These compounds exhibit excellent photostability and low skin toxicity, showing broad application prospects.

The application discloses a synthesis method of Triclabendazole, which comprises the following steps: starting from a compound of formula (11) and a compound of formula (10), a Pictet-Spengler reaction is performed, then intermolecular aldol condensation of a compound of formula (8) and a compound of formula (14) is performed, a fragment connection product of formula (15) is obtained through the reaction, then asymmetric ketal oxidation is performed to obtain a compound of formula (19-II), an intramolecular Stecker reaction is performed to obtain a compound of formula (5), then stereoselective decarboxylation protonation of palladium catalysis is performed to obtain a compound of formula (3), then a protecting group is removed, and an ethyl ester is reduced to obtain a compound of formula (26); then, the Triclabendazole shown in formula (A) is synthesized from the compound of formula (26). The method is mild in conditions, simple in operation, and raw materials are easy to obtain, and is suitable for large-scale production.

The invention discloses a preparation method and application of an electrochemical chiral sensor material L-Ni-BDC / NM88B (Fe) based on a chiral MOF-on-MOF heterostructure, and belongs to the technical field of electrochemical chiral sensing recognition materials. According to the technical scheme, the preparation method comprises the following steps: firstly, dissolving ferric chloride hexahydrate and 2-aminoterephthalic acid in an alkaline solution, and carrying out hydrothermal reaction to prepare NH2-MIL-88B (Fe); and then the NH2-MIL-88B (Fe) is dissolved in an acid solution containing terephthalic acid and nickel chloride hexahydrate, and the composite material Ni-BDC / NM88B (Fe) is prepared through a hydrothermal reaction. And continuously adding EDC and NHS to activate carboxyl of TPA, then adding a protonated cysteine solution, and carrying out an amidation reaction to prepare a target product. A sensor prepared from the material prepared by the invention can quickly and sensitively identify L-tryptophan in tryptophan isomers.

The invention relates to a method for detecting tertiary amine type niash substances. The method aims at solving the problems that in electrospray ionization source mass spectrometry analysis of tertiary amine type niash substances, parts with structural differences are lost in the form of neutral fragments, mass spectrometry data of the tertiary amine type niash substances are basically the same, and qualitative analysis of structural identification cannot be carried out through the mass spectrometry data. According to the invention, a tertiary amine type niash substance is converted into a corresponding N-oxide through an oxidation pretreatment method, and the protonation position of the tertiary amine type niash substance in an electrospray ion source is changed, so that a part with functional group difference in the structure can generate fragments with positive electrons, and the characteristics of functional groups in the structure are reflected; the purpose of structural identification qualitative analysis through mass spectrum characteristic fragment data is achieved. The method is simple and convenient to operate, is suitable for mass spectrometry of a conventional electrospray ionization source and a neutral gas collision cell, and can provide an effective technical means for reliable identification and judicial expertise of the substance.