315results about "Amphoteric ion-exchangers" patented technology

A full solid-waste micro-expansive concrete and its preparation method are provided, and relate to the field of concrete material technologies. The full solid-waste micro-expansive concrete includes the following components in parts by weight: 920-1060 parts of a coarse aggregate, 460-582 parts of a fine aggregate, 11-19 parts of an expansive agent, 389-512 parts of a modified solid-waste-based cementitious material, and 231-268 parts of water. The coarse aggregate is coal gangue. The fine aggregate is waste ceramic. The modified solid-waste-based cementitious material includes a solid-waste-based clinker, modified polyvinyl alcohol, and a modified anion exchange resin. The solid-waste-based clinker is prepared from the coal gangue, carbide slag, and desulfurization gypsum. The expansive agent is obtained by calcining the carbide slag. The concrete prepared can ensure the initial strength of the concrete, and guarantee continuous micro-expansion in the later stage, compensating for shrinkage and thereby increasing the overall strength of the concrete.

The invention relates to the technical field of biomacromolecule separation and purification engineering, and discloses a chromatographic separation method for removing endotoxin in a vaccine preparation, which comprises the following steps: preparing an equilibrium buffer solution containing citrate with specific concentration and L-arginine hydrochloride; providing a mixed mode chromatography medium with hydrophobic and ion exchange complex ligands and balancing with a buffer; according to the method, through the synergistic effect of 8.0-12.0 mmol / L of citrate and 150-250 mmol / L of L-arginine hydrochloride, the endotoxin micelle structure is destroyed and is induced to be dissociated into monomers, and meanwhile, L-arginine is used for inhibiting monomer aggregation, so that the monomers are diffused into inner holes of the medium in a small size to be adsorbed, and the endotoxin micelle structure is separated into the medium. Therefore, the problem of separation caused by size overlapping of endotoxin micelles and antigens is solved, and double breakthrough of deep removal of endotoxin and high recovery rate of antigens is realized.

A waste extraction system that includes a column set positioned between and fluidly coupled to an upstream segment of a main waste pathway and a column effluent tank, the column set having a uranium adsorption column fluidly coupled to a supporting adsorption column along the main waste pathway. The uranium adsorption column is upstream the supporting adsorption column. The waste extraction system also includes a strip waste pathway extending from the uranium adsorption column to the column effluent tank bypassing the supporting adsorption column, an anion exchange resin housed in the uranium adsorption column, and a cation exchange resin housed in the supporting adsorption column.

The present invention relates to methods and devices for isolating one or more biomolecules of interest from a biological composition. Specifically, the invention relates to the separation of one or more target biomolecules from a biological composition by dynamic packed bed adsorption using a separation medium comprising porous rod-like particles attached to the target molecules and filtration using a filter having a pore size of at least 1.5 [mu] m.

A substantially animal-protein free (APF) composition comprises a botulinum toxin serotype A neurotoxin having a molecular weight of 150 kDa, comprising one nanogram or less of residual nucleic acid for each milligram of the botulinum neurotoxin component, wherein the botulinum toxin serotype A neurotoxin is obtainable by a process comprising the steps of (a) providing a substantially APF fermentation medium; (b) fermenting Clostridium botulinum bacteria in the fermentation medium, and; (c) recovering the biologically active botulinum neurotoxin from the fermentation medium by contacting the fermentation medium with an anion exchange chromatography media followed by contacting an eluent from the anion exchange chromatography medium with a cation exchange chromatography media.

The present application provides a chromatographic baseline suppression device and a manufacturing method thereof, the chromatographic baseline suppression device comprises a container and two ion exchange membranes, the two ion exchange membranes divide the inside of the container into a first part, a second part and a third part, the second part has an inlet and an outlet; the chromatographic baseline suppression device further comprises two electrodes respectively in the first part and the second part, the electrodes comprise a matrix porous material layer and a polymer layer, the matrix porous material layer is conductive and is connected with the ion exchange membrane. The present application has the advantages of small noise and the like.

The present application relates to the technical field of ion detection, in particular to a high-efficiency anti-interference ion chromatography detection device and method, through sample pretreatment module, the original sample is filtered, enriched and interference shielding processing, effectively removes impurities and shields interfering ions, at the same time, the chromatographic separation module realizes the simultaneous separation of anions and cations under constant temperature conditions, avoids the problems of chromatographic peak overlap and tailing under the traditional single separation mechanism, significantly improves the detection stability and accuracy of complex matrix samples; the eluent supply module generates high-purity eluent online to avoid impurity pollution caused by manual preparation, the detection module reduces the background conductance in the ion flow and converts the ion concentration change into an electrical signal, effectively reduces the baseline noise, meets the high-sensitivity detection requirement of trace ions; the central control unit controls the cooperative work of each module, greatly shortens the analysis time, and is suitable for rapid detection of large quantities of samples.

The application discloses a process for separating and purifying a mixed solution of HCl and NaCl by using a chromatographic technique. Liquid containing HCl and NaCl is loaded into a chromatographic column containing an anion exchange resin, adsorbed, washed, desorbed, and the effluent is collected. The application uses acid retardation and ion exchange mechanism, adopts fixed bed technology, and realizes the purpose of removing NaCl and separating and purifying high-concentration HCl in one step. The whole process does not use acid and alkali, the Na content in the product liquid is lower than the ion chromatography detection limit, the yield of HCl reaches more than 95%, and the average concentration reaches more than 50%. + The application also uses ultrapure water as a desorbent, so that the product elution and resin regeneration are completed at the same time, and the process is simplified.

The disclosure provides preparation and application of an anionic resin with high selective adsorption of ergothioneine, belonging to the field of biochemical engineering. A polyamine-type epoxy weak-base anionic resin is used as a carrier for the first time. Ni atoms are loaded onto the target resin carrier in the form of [NiCl4]2— ions, followed by in situ reduction and rinsing regeneration to prepare a metal Ni nanoparticle-loaded polyamine-type epoxy weak-base anionic resin. The preparation process is simple and the stability is good. The disclosure has strong selective adsorption for ergothioneine in fermentation broths and the facile elution. The disclosure can be widely applied in purification processes for ergothioneine preparation through fermentation and enzymatic catalysis.

The present disclosure is generally directed to polymers comprising repeat units having the structures of Formulae 1, 2, and 3. These polymers are used in methods of removing contaminants, including PFAS and heavy metals, from an aqueous fluid comprising contacting the aqueous fluid with the polymer and in methods of catalyzing an organic transformation comprising contacting a fluid with a catalytic amount of the polymer.

The utility model discloses a desalting device for production of methyltrimethoxysilane, which comprises a base, vertical plates fixedly connected to the left end and the right end of the upper surface of the base, a temporary storage box arranged between the two vertical plates, two mounting discs fixedly connected to the surface of the temporary storage box, and the two mounting discs are oppositely distributed up and down. A plurality of automatic telescopic rods are fixedly connected to the upper surface of the base, limiting assemblies are arranged at the upper ends of the automatic telescopic rods and the lower surface of the lower mounting disc, a built-in box is fixedly connected to the interior of the temporary storage box, two liquid guide pipes are fixedly connected to the lower surface of the temporary storage box, and long plates are arranged in the built-in box and the temporary storage box correspondingly; the surfaces of the long plates are fixedly connected with a plurality of ion exchange resin storage boxes, and the faces, away from the ion exchange resin storage boxes, of the two long plates make close contact with the front inner wall of the temporary storage box and the rear inner wall of the built-in box correspondingly. Through the structure, the occupied area of the desalting device is reduced, and the convenience of replacing articles in the device is improved.

The application discloses a processing equipment for crude heparin sodium and belongs to the field of heparin sodium preparation, which comprises a shell, a liquid discharge port arranged at the lower end of the shell, a cover one fixed at the upper end of the shell, a liquid inlet arranged on the cover one, and an adsorption assembly arranged in the shell. The adsorption assembly comprises a plurality of supporting pieces fixed to the inner bottom wall of the shell, a filter cartridge clamped to the upper ends of the supporting pieces, a cavity and a hollow cavity arranged in the filter cartridge, and a cover two fixed to the upper end of the filter cartridge and sealing the cavity. The cavity for placing the resin is arranged in the filter cartridge, the resin is confined in the filter cartridge, direct contact with the high-speed rotating stirring paddle is avoided, and the resin is not damaged by the high-speed rotating stirring paddle. The paddle in the hollow cavity can actively and continuously suck the liquid from the bottom of the filter cartridge, and force the liquid to penetrate the resin bed in the radial direction. The radial flow has a large cross-sectional area, a short path, and a more uniform fluid distribution, and the utilization rate of the resin is higher.

The present disclosure relates to an automated device and methods to produce a highly purified alpha-emitting radioisotope Pb-212 from a pre-filled column of a parent isotope Ra-224 for use in targeted alpha-particle therapy.

The present disclosure provides a simple and versatile process suitable for large-scale production of alpha emitters. It does not require irradiation of the source material and it is based on aqueous solutions and a strong cation exchange resin.

The invention discloses a multi-mode liquid chromatography filler of ionic liquid hydrogel modified silica gel and preparation and application thereof, and the method comprises the following steps: fully dissolving an ionic liquid hydrogel monomer and a cross-linking agent in a polar aprotic organic solvent, adding silica gel, carrying out ultrasonic treatment, and standing; adding an initiator, stirring, condensing, refluxing, stirring and reacting at 70-80 DEG C in an inert atmosphere; and drying under stirring, centrifugally washing and drying. According to the invention, the problems of single functional group, tedious modification steps, low ligand density and poor high-pressure stability in the existing method are solved. The preparation method is simple and convenient, efficient modification of hydrogel on the surface of silica gel can be achieved, and the prepared liquid chromatography packing has good separation selectivity on nucleoside / basic groups, organic acid compounds, alkaloid, antibiotics, aniline compounds, anion-containing compounds and the like; and chromatographic separation in a hydrophilic chromatographic mode, a hydrophobic chromatographic mode and an ion exchange chromatographic mode can be realized.

The present invention provides an ion exchange membrane that has excellent electrolyte resistance and battery characteristics, and facilitates the manufacture of electrochemical cells. [Solution] An ion exchange membrane comprising a polybenzimidazole or a derivative thereof represented by formula (1), wherein the ion exchange membrane comprises a dense layer and a porous layer, the dense layer is provided at either end of the porous layer, and the thickness of the dense layer is 0.1 to 10 μm. JPEG2026104048000009.jpg46146 (In general formula (1), R 1 R is a tetravalent aromatic unit that can form an imidazole ring. 2 (where X represents a divalent aromatic group, and Y represents a group containing an anionic functional group, and Y represents a group containing a hydrogen atom or a cationic functional group.)

Ion exchange membranes (e.g., anion exchange membranes) and methods of using the membranes are described. The ion exchange membranes are multi-modal ion exchange membranes containing a plurality of multi-modal exchange ligands. The membranes can achieve high dynamic and equilibrium binding capacities at solution conductivities typical for production of biologics (e.g., greater than about 10 mS / cm) and can provide excellent binding at high flow rates. Systems incorporating the membranes can dramatically increase isolation and purification speeds. Membranes are disclosed for use in production of biologics.

The present invention pertains to the purification of soluble complement receptor proteins and variants thereof by hydrophobic interaction chromatography (HIC) using a chromatographic material with a particle size of less than 60 µm.

The subject invention pertains to multimodal chromatography resins comprising anionic and cationic ligands on each resin particle and methods of synthesizing the multimodal chromatography resin by contacting a base with quaternary amines and / or tertiary amines on the surface of a substrate. The multimodal resins can be tuned by changing the ratios of cation to anions. The multimodal chromatography resins can be used for purifying proteins.

A production method for water for pure water includes adding polyaluminum chloride to raw water to produce first treated water, and filtering the first treated water in two or more stages including filtering with a filtration membrane device in a preceding stage to produce first concentrated water, and filtering the first concentrated water with a filtration membrane device in a subsequent stage. The water for pure water is produced as permeated water produced by the filtering in the two or more stages.

Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

A process for purifying (i) a hydrophilic organic solvent, (ii) a hydrolysable organic solvent, or (iii) a mixture of a hydrophilic organic solvent and a hydrolysable organic solvent by removing ionic contaminants from the hydrophilic organic solvent, from the hydrolysable organic solvent, or from the mixture of a hydrophilic and a hydrolysable organic solvent without generation of by-product impurities, the process including the steps of contacting the hydrophilic organic solvent, the hydrolysable organic solvent, or the mixture of hydrophilic and hydrolysable organic solvents with a mixed bed of ion exchange resin; wherein the mixed bed of ion exchange resin includes a mixture of: (a) a weak-acid cationic ion exchange resin and (b) a weak-base anionic ion exchange resin.

A chromatography system comprising at least two chromatography units (3) connected in parallel, wherein said at least two chromatography units (3) each comprises a convection-based chromatography material, wherein an initial difference in back pressure provided from the different chromatography units (3) is compensated dynamically during run of the system due to a change of chromatography unit properties provided during the chromatography process.

The application belongs to the technical field of functional polymer membrane materials, and particularly relates to a preparation method of a flexible ion exchange membrane for water purification and desalination, a product thereof and application, comprising melt blending, online compounding and calendering of cation exchange resin powder, a flexible binder containing maleic anhydride grafted polypropylene and thermoplastic polyurethane, and a reinforcing mesh cloth to form a heterogeneous support base film with a mesh reinforcing structure; preparing an anion exchange layer coating liquid containing perfluorosulfonic acid resin and a cation exchange layer coating liquid; respectively casting and coating the anion exchange layer coating liquid and the cation exchange layer coating liquid on two surfaces of the heterogeneous support base film, and after drying and heat treatment, forming a homogeneous functional surface layer which is tightly combined with the base film. The application introduces continuous and dense homogeneous conductive layers on the two sides of the anion and the cation respectively while maintaining the mechanical support and dimensional stability of the heterogeneous membrane, shortens the ion migration path, reduces the membrane surface resistance and improves the interface bonding strength.

Provided is a method for refining a pyrolysis oil including: supplying a waste plastic raw material to a pyrolysis reactor to perform pyrolysis, and discharging a gaseous stream produced by the pyrolysis upwards; supplying an upper discharge stream from the pyrolysis reactor to a distillation column, and discharging a pyrolysis oil stream having a decreased content of a heavy oil fraction from the distillation column; and supplying the pyrolysis oil stream to an anion exchange resin column to bring the stream into contact with the anion exchange resin and remove impurities included in the pyrolysis oil stream.

Described herein are membrane assemblies for use in generating hydrogen and oxygen. The membrane assemblies include a cation exchange membrane, an anion exchange membrane, and a hydrophilic layer disposed between the anion exchange membrane and the cation exchange membrane.

The present disclosure is directed to methods and systems of purifying bioderived organic solvents. The purified bioderived organic solvents can be used in a multistep semiconductor manufacturing process.

The invention provides an ultra-trace metal ion capture type electronic-grade L (+)-tartaric acid purification system, and relates to the technical field of chemical purification. An adopted system sequentially comprises a feeding pretreatment unit, a multi-tooth coordination resin capturing unit, a double-layer chelating membrane deep purification unit, a multi-stage membrane separation unit and a whole-system online monitoring and control unit in the fluid flowing direction. A metal-tartaric acid complex is controllably deconstructed through the feeding end, metal activation is induced, differential selective capture is achieved in combination with gradient filling of multi-tooth resin, and ppb and sub-ppb-level metal removal is achieved in cooperation with a double-layer chelating membrane and micro-ultrasonic mass transfer strengthening. Meanwhile, the system adopts online electrochemical sensing, an optical probe and a virtual sensor to construct a polymorphic metal detection and Kalman filtering predictive control model, so that prospective regulation, dynamic regeneration and abnormal interception are realized, and metal ions such as Ni < + > and Fe < + > are ensured to be stably as low as a sub-ppb level; and continuous output of the electronic-grade tartaric acid under the conditions of high purity, high stability and traceability is ensured.

The present disclosure relates to a preparation method for L-citrulline, comprising: Step 1 of preparing a fermentation broth comprising L-citrulline; Step 2 of performing a continuous chromatography process on the fermentation broth to obtain a purified citrulline process liquid; and Step 3 of crystallizing and separating L-citrulline in the purified citrulline process liquid. According to the present disclosure, high purity L-citrulline crystals can be obtained in high yield from the fermentation broth.